IL-17

Summary

Gene Symbol: IL-17
Description: interleukin 17A
Alias: CTLA-8, CTLA8, IL-17, IL-17A, IL17, interleukin-17A, cytotoxic T-lymphocyte-associated antigen 8, cytotoxic T-lymphocyte-associated protein 8, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
Species: human

Top Publications

  1. pmc Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells
    Elizabeth M Bradshaw
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:4432-9. 2009
  2. doi Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity
    Chun Kwok Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Immunol 127:385-93. 2008
  3. pmc 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A
    Sneha Joshi
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Mol Cell Biol 31:3653-69. 2011
  4. pmc Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    Lorenzo Cosmi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
    J Exp Med 205:1903-16. 2008
  5. pmc Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer
    Yoshihiro Miyahara
    Department of Pathology and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:15505-10. 2008
  6. pmc Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    Andrew M Lin
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 187:490-500. 2011
  7. pmc IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction
    Shiva Shahrara
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 184:4479-87. 2010
  8. ncbi CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
    E Rouvier
    Centre d Immunologie INSERM CNRS de Marseille Luminy, France
    J Immunol 150:5445-56. 1993
  9. doi Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis
    Hui Shen
    University of Cambridge, Department of Medicine, and Addenbrooke s Hospital, Cambridge, UK
    Arthritis Rheum 60:1647-56. 2009
  10. pmc Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells
    Raymond E Eid
    Interdepartmental Program in Vascular Biology and Therapeutics and Department of Surgery, Yale University School of Medicine, New Haven, Conn, USA
    Circulation 119:1424-32. 2009

Research Grants

  1. IL-23 / Il-17 and Lung Host Defense
    Jay Kolls; Fiscal Year: 2009
  2. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
  3. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
  4. MARK DOUGLAS OKUSA; Fiscal Year: 2014
  5. Trim32 Regulation of Piasy in Skin Homeostasis
    Molly F Kulesz-Martin; Fiscal Year: 2013
  6. Sam T Hwang; Fiscal Year: 2016
  7. GINGIVA DERIVED MSCS: ROLE IN IMMUNOMODULATION AND TISSUE REGENERATION
    Yufang Shi; Fiscal Year: 2013
  8. Ragini Vittal; Fiscal Year: 2015
  9. Fcgamma mediated regulation of dendritic cell function
    Kavita Dhodapkar; Fiscal Year: 2012
  10. Thalachallour Mohanakumar; Fiscal Year: 2015

Detail Information

Publications297 found, 100 shown here

  1. pmc Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells
    Elizabeth M Bradshaw
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:4432-9. 2009
    ..These data suggest that the innate immune system in T1D may drive the adaptive immune system by expanding the Th17 population of effector T cells...
  2. doi Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity
    Chun Kwok Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Immunol 127:385-93. 2008
    ..05). Ex vivo inductions of IL-17 by IL-23 or IL-18 from co-stimulated lymphocytes were significantly higher in SLE patients than controls (all p<0.05). The activated IL-23/IL-17 axis is important for the inflammatory immunity in SLE...
  3. pmc 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A
    Sneha Joshi
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Mol Cell Biol 31:3653-69. 2011
    ..Our results describe novel mechanisms and new concepts with regard to vitamin D and the immune system and suggest therapeutic targets for the control of autoimmune diseases...
  4. pmc Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    Lorenzo Cosmi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
    J Exp Med 205:1903-16. 2008
    ..These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor...
  5. pmc Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer
    Yoshihiro Miyahara
    Department of Pathology and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:15505-10. 2008
    ..These findings should accelerate efforts to define the function of this important subset of CD4(+) T cells in the human immune response to cancer...
  6. pmc Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    Andrew M Lin
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 187:490-500. 2011
    ..Release of IL-17 from innate immune cells may be central to the pathogenesis of psoriasis, representing a fundamental mechanism by which the IL-23-IL-17 axis mediates host defense and autoimmunity...
  7. pmc IL-17-mediated monocyte migration occurs partially through CC chemokine ligand 2/monocyte chemoattractant protein-1 induction
    Shiva Shahrara
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 184:4479-87. 2010
    ....
  8. ncbi CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
    E Rouvier
    Centre d Immunologie INSERM CNRS de Marseille Luminy, France
    J Immunol 150:5445-56. 1993
    ..More generally, CTLA-8 may belong to the growing set of virus-captured functionally important cellular genes related to the immune system or to cell death and cell survival...
  9. doi Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis
    Hui Shen
    University of Cambridge, Department of Medicine, and Addenbrooke s Hospital, Cambridge, UK
    Arthritis Rheum 60:1647-56. 2009
    ....
  10. pmc Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells
    Raymond E Eid
    Interdepartmental Program in Vascular Biology and Therapeutics and Department of Surgery, Yale University School of Medicine, New Haven, Conn, USA
    Circulation 119:1424-32. 2009
    ..We investigated whether interleukin (IL)-17, the signature cytokine of Th17 cells, is also associated with human coronary atherosclerosis...
  11. pmc Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression
    Jian Li
    Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e21816. 2011
    ..The aim of this study is to investigate the effect of IL-17A on the progression of hepatocellular carcinoma (HCC)...
  12. pmc Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma
    Kavita M Dhodapkar
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY, USA
    Blood 112:2878-85. 2008
    b>IL17-producing (Th17) cells are a distinct lineage of T helper cells that regulate immunity and inflammation. The role of antigen-presenting cells in the induction of Th17 cells in humans remains to be fully defined...
  13. ncbi IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma
    Chuanwang Song
    Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People s Republic of China
    J Immunol 181:6117-24. 2008
    ..Mast cell-released mediators up-regulate the expression of IL-17 by macrophages, whereas IL-10 down-regulates IL-17 expression...
  14. doi Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes
    Ashish K Marwaha
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 185:3814-8. 2010
    ..Moreover, these T1D subjects had a higher proportion of both CD4(+) and CD8(+) T cells that secrete IL-17. The bias toward IL-17-secreting T cells in T1D suggests a role for this proinflammatory cytokine in the pathogenesis of disease...
  15. ncbi The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98, Dengakugakubo, Kutsukake cho, Toyoake 470 1192, Japan
    J Clin Immunol 28:44-9. 2008
    ..Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently...
  16. doi Association analysis of the interleukin 17A gene in Caucasian rheumatoid arthritis patients from Norway and New Zealand
    Gry B N Nordang
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Rheumatology (Oxford) 48:367-70. 2009
    ..Our aim was to investigate IL17A as a candidate gene for RA, and to assess correlations between risk variants and disease phenotypes...
  17. doi Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 88:227-32. 2010
    ..These findings contribute to a better understanding of the host response to mycobacteria and provide the opportunity to explore potential, novel, therapeutic strategies against TB...
  18. doi Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patients
    Xi Chen
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Xinqiao Street No 30, Chongqing 400037, China
    Lung Cancer 69:348-54. 2010
    ..Our results indicate that IL-17 may play a role in the metastasis of lung cancer by promoting lymphangiogenesis. IL-17 expression is an independent prognostic factor in both overall and disease-free survival in NSCLC...
  19. doi Genetic polymorphisms of IL-23R and IL-17A and novel insights into their associations with inflammatory bowel disease
    Seung Won Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    Gut 60:1527-36. 2011
    ..To identify the associations of genetic and epigenetic variations in IL-23R and IL-17A with inflammatory bowel diseases (IBD)...
  20. pmc Gastrokine 1 regulates NF-κB signaling pathway and cytokine expression in gastric cancers
    Jung Hwan Yoon
    Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Seocho Gu, Seoul 137 701, Korea
    J Cell Biochem 114:1800-9. 2013
    ..These data suggest that the GKN1 gene may inhibit progression of gastric epithelial cells to cancer cells by regulating NF-κB signaling pathway and cytokine expression...
  21. ncbi MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis
    A Beklen
    Department of Medicine Invärtes Medicin, Helsinki University Central Hospital, Helsinki, Finland
    J Dent Res 86:347-51. 2007
    ..Gingival fibroblasts may play an important role in tissue destruction in periodontitis via cytokine-inducible MMP-1 and MMP-3 production, in which IL-17 plays a role as a key regulatory cytokine...
  22. pmc Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection
    Deepak A Rao
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 205:3145-58. 2008
    ....
  23. pmc Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells
    Mostafa A Gabr
    Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA
    J Orthop Res 29:1-7. 2011
    ..IL-17 may be an important regulator of inflammation in the IVD pathologies...
  24. doi IL-17 and tumour necrosis factor α combination induces a HIF-1α-dependent invasive phenotype in synoviocytes
    Arnaud Hot
    Department of Clinical Immunology and Rheumatology and Immunogenomics and Inflammation Research Unit, Hopital Edouard Herriot, University of Lyon 1, Lyon, France
    Ann Rheum Dis 71:1393-401. 2012
    ..To examine the effect of interleukin-17 (IL-17) on rheumatoid arthritis (RA) synoviocyte migration and invasiveness...
  25. doi Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis
    Tomoyuki Shibata
    Department of Gatroenterology, Fujita Health University, Toyoake, Japan
    Hum Immunol 70:547-51. 2009
    ..022). We concluded that G-197A polymorphism of IL-17A gene was significantly associated with the development of gastric cancer, especially intestinal-type cancer...
  26. pmc Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells
    B Afzali
    MRC Centre for Transplantation and NIHR Biomedical Research Centre, King s College, Guy s Hospital, London, UK
    Clin Exp Immunol 159:120-30. 2010
    ..In this paper, we review T(reg) to Th17 conversion and propose some potential mechanisms for this phenomenon...
  27. ncbi Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB
    T Shalom-Barak
    Division of Arthritis Research, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 273:27467-73. 1998
    ..These results suggest that IL-17 activation of chondrocytes is associated with and depends at least in part on the activation of MAP kinases and NF-kappaB...
  28. pmc Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    John S Tzartos
    Department of Neuropathology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Am J Pathol 172:146-55. 2008
    ....
  29. doi Analysis of IL-6, IL-10 and IL-17 genetic polymorphisms as risk factors for sepsis development in burned patients
    A Accardo Palumbo
    Plastic Surgery and Burns Therapy Operating Unit, ARNAS, Civic Hospital, Palermo, Italy
    Burns 38:208-13. 2012
    ....
  30. doi Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses
    M Macal
    Department of Medical Microbiology and Immunology, University of California, Davis, California, USA
    Mucosal Immunol 1:475-88. 2008
    ..Our findings suggest that a threshold of>50% CD4+ T-cell restoration may be sufficient for polyfunctional HIV-specific T cells with implications in the evaluation of vaccines and therapeutics...
  31. doi Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer
    Xiaoqin Wu
    Department of Gastroenterology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Int J Cancer 127:86-92. 2010
    ..These findings suggest that polymorphism of IL-17F 7488 involved in susceptibility to gastric cancer, which also influenced certain subtypes according to clinicopathological features, whereas IL-17A 197 may be less relevant...
  32. pmc Human eosinophils release IL-1ß and increase expression of IL-17A in activated CD4+ T lymphocytes
    S Esnault
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Clin Exp Allergy 42:1756-64. 2012
    ..We have shown that eosinophils (EOS) have the potential to influence Th1 and Th2 cytokine generation by CD4(+) cells, but their influence on IL-17A (IL-17) has not been established...
  33. doi The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population
    J Y Wang
    Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan
    Allergy 64:1056-60. 2009
    The interleukin 17A (IL17A) gene, located on chromosome 6p and linked to asthma phenotype, is a highly potential candidate gene conferring asthma susceptibility...
  34. pmc Staphylococcal alpha-toxin is a strong inducer of interleukin-17 in humans
    Margarete Niebuhr
    Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany
    Infect Immun 79:1615-22. 2011
    ..In conclusion, higher levels of IL-17A secretion induced by alpha-toxin in the skin partially explain how colonization with S. aureus can contribute to chronic skin inflammation...
  35. doi Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University and Assir Central Hospitals, Assuit, Egypt
    Pathol Oncol Res 14:321-8. 2008
    ..To conclude, the development of rheumatoid arthritis and osteoarthritis is associated with alteration of the levels of some cytokines. The assessment of these immunologic changes may have potential prognostic roles...
  36. doi Transforming growth factor beta-1 and interleukin-17 gene transcription in peripheral blood mononuclear cells and the human response to infection
    Mary White
    Department of Anaesthesia, St James Hospital, Dublin 8, Ireland Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Cytokine 50:322-7. 2010
    ..We investigated the hypothesis that the onset of sepsis is related to differential TGFbeta-1 and IL-17 gene expression...
  37. pmc Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO Rep 11:640-6. 2010
    ..In mice, IFNgamma decreased IL-1beta and subsequently IL-17, indicating that the adaptive immune response can provide a systemic, but transient, signal to limit inflammation...
  38. ncbi Interleukin-11 and IL-17 and the pathogenesis of periodontal disease
    R B Johnson
    Department of Periodontics, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    J Periodontol 75:37-43. 2004
    ..Our purpose was to compare concentrations of human IL-11 and IL-17 within healthy and diseased human gingiva to determine their possible role in the initiation or progression of periodontal diseases...
  39. ncbi Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease?
    Maki Murata
    J Dermatol Sci 50:240-2. 2008
  40. ncbi Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17
    Xikui K Liu
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, SUNY, Buffalo, New York 14214, USA
    J Biol Chem 279:52762-71. 2004
    ..Together, these data show that NFAT is the crucial sensor of TCR signaling in the IL-17 promoter...
  41. pmc Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis
    Ilona Kryczek
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Immunol 181:4733-41. 2008
    ....
  42. pmc Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma
    Rao H Prabhala
    Veterans Administration Boston Healthcare System, West Roxbury, MA
    Blood 115:5385-92. 2010
    ..In conclusion, IL-17-producing T(h)17 cells play an important role in MM pathobiology and may be an important therapeutic target for anti-MM activity and to improve immune function...
  43. doi IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma
    Jiankun Liu
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China
    Biochem Biophys Res Commun 407:348-54. 2011
    ....
  44. doi Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation
    Chun Feng Yu
    Department of Dermatology and Allergy, University Hospital, University of Bonn, Bonn, Germany
    J Immunol 184:1159-67. 2010
    ....
  45. doi Interleukin-17A gene variants and risk of coronary artery disease: a large angiography-based study
    Xiaolin Zhang
    Department of Cardiology, Northern Hospital, 83 Wenhua Road, Shenyang 110016, People s Republic of China
    Clin Chim Acta 412:327-31. 2011
    ....
  46. ncbi Association of genetic polymorphisms in IL17A and IL17F with gastro-duodenal diseases
    Ranji Hayashi
    Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
    J Gastrointestin Liver Dis 21:243-9. 2012
    ..pylori) colonization has been indicated. We investigated the associations between gastro-duodenal diseases and polymorphisms of IL17A (rs2275913 G>A) and IL17F (rs763780 T>C)...
  47. doi The interleukin 17 system in cortical lesions in focal cortical dysplasias
    Jiao Jiang He
    From the Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    J Neuropathol Exp Neurol 72:152-63. 2013
    ....
  48. pmc T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    F Fossiez
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    J Exp Med 183:2593-603. 1996
    Analysis of the cDNA encoding murine interleukin (IL) 17 (cytotoxic T lymphocyte associated antigen 8) predicted a secreted protein sharing 57% amino acid identity with the protein predicted from ORF13, an open reading frame of ..
  49. ncbi Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways
    M Laan
    Lung Pharmacology Group, Department of Respiratory Medicine and Allergology, Goteborg University, Sweden
    J Immunol 162:2347-52. 1999
    ....
  50. pmc Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease
    S Q Crome
    Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, Canada
    Clin Exp Immunol 159:109-19. 2010
    ..Herein, we will discuss the molecular and cellular regulation of Th17 cells with an emphasis on studies in humans...
  51. doi Inflammatory cytokines IL-32 and IL-17 have common signaling intermediates despite differential dependence on TNF-receptor 1
    Emily Turner-Brannen
    Department of Internal Medicine, Manitoba Centre for Proteomics and Systems Biology, University of Manitoba, Winnipeg, Manitoba R3E3P4, Canada
    J Immunol 186:7127-35. 2011
    ..Therefore, p300 and DAPK-1 are viable potential therapeutic targets for chronic inflammatory diseases...
  52. doi Reduced expression of transforming growth factor-β1 and correlated elevation of interleukin-17 and interferon-γ in pediatric patients with chronic primary immune thrombocytopenia (ITP)
    Jiaan Der Wang
    Division of Pediatric Hematology, Taichung Veterans General Hospital, Taichung City, Taiwan
    Pediatr Blood Cancer 57:636-40. 2011
    ..The present study investigated whether levels of Th cytokines in pediatric patients with chronic ITP were different compared with healthy controls...
  53. ncbi IL-17 patterns in synovium, serum and synovial fluid from treatment-naïve, early rheumatoid arthritis patients
    Anca Rosu
    Department of Internal Medicine and Rheumatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania
    Rom J Morphol Embryol 53:73-80. 2012
    ..There are actually becoming controversial data regarding the profiles of interleukin-17 (IL-17) in different pathogenical stages of rheumatoid arthritis (RA)...
  54. doi Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion
    Alexandra M Nanzer
    MRC and the Asthma UK Centre for Allergic Mechanisms in Asthma, King s College London, London, United Kingdom
    J Allergy Clin Immunol 132:297-304.e3. 2013
    ..We previously identified a steroid-enhancing function of vitamin D in patients with SR asthma in restoring the impaired response to steroids for production of the anti-inflammatory cytokine IL-10...
  55. pmc IL4 and IL-17A provide a Th2/Th17-polarized inflammatory milieu in favor of TGF-β1 to induce bronchial epithelial-mesenchymal transition (EMT)
    Xiaoying Ji
    Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, China
    Int J Clin Exp Pathol 6:1481-92. 2013
    ....
  56. ncbi Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway
    H C Shin
    Laboratoire d Immunologie, Faculté de Pharmacie de Reims, France
    Cytokine 10:841-50. 1998
    ....
  57. pmc Distinct roles of transforming growth factor-beta-activated kinase 1 (TAK1)-c-Rel and interferon regulatory factor 4 (IRF4) pathways in human T cell lymphotropic virus 1-transformed T helper 17 cells producing interleukin-9
    Alaa Refaat
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    J Biol Chem 286:21092-9. 2011
    ..Collectively, these findings indicate that TAK1-c-Rel and IRF4 pathways play distinct roles in the maintenance of IL-9-producing Th17 phenotype of HTLV-1-transformed cells...
  58. ncbi Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
    Fei Huang
    Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USA
    J Immunol 179:6504-13. 2007
    ....
  59. pmc IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    S Kotake
    The Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    J Clin Invest 103:1345-52. 1999
    ....
  60. doi TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin
    Ainara Castellanos-Rubio
    Endocrinology, Diabetes and Nutrition Research Group, Immunogenetics Laboratory, Hospital de Cruces, Bizkaia, Spain
    Autoimmunity 42:69-73. 2009
    ....
  61. doi IL-17 stimulates migration of carotid artery vascular smooth muscle cells in an MMP-9 dependent manner via p38 MAPK and ERK1/2-dependent NF-kappaB and AP-1 activation
    Gao Cheng
    Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Cell Mol Neurobiol 29:1161-8. 2009
    ..The present results demonstrated that IL-17 may play a role in vascular remodeling and targeting IL-17 or its specific downstream mediators is a potentially novel therapeutic pathway for attenuating the post-angioplastic restenosis...
  62. ncbi Human IL-17: a novel cytokine derived from T cells
    Z Yao
    Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 155:5483-6. 1995
    ..acid identity with HVS13, an open reading frame from a T-lymphotropic Herpesvirus saimiri, and 63% with murine CTLA8. High levels of hIL-17 were induced from primary peripheral blood CD4+ T cells upon stimulation...
  63. ncbi Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Biochim Biophys Acta 1591:69-74. 2002
    ..This indicates that activation of the ERK pathway is involved in the induction of IL-6 mRNA stabilization by IL-17 plus TNF-alpha...
  64. ncbi Interleukin-17 increases the effects of IL-1 beta on muscle cells: arguments for the role of T cells in the pathogenesis of myositis
    G Chevrel
    Department of Immunology and Rheumatology, Hopital E Herriot, 5 Place d Arsonval, 69437 Lyon Cedex 03, France
    J Neuroimmunol 137:125-33. 2003
    ..Our study shows that low levels of cytokines produced by T cells (IL-17) and monocytes (IL-1 beta) can act in combination on skeletal myoblasts and muscle tissue...
  65. ncbi Tax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells
    Madeleine Duc Dodon
    Virologie Humaine INSERM U412, Ecole Normale Superieure de Lyon, IFR 128 Biosciences Lyon Gerland, 46 allee d Italie, 69364 Lyon Cedex 07, France
    J Gen Virol 85:1921-32. 2004
    ..In this study, it was observed that Tax upregulated the expression of human interleukin 17 (IL17), a cytokine mainly produced by activated CD4(+) memory T cells...
  66. ncbi Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Clin Rheumatol 26:2137-41. 2007
    ..In addition, SNPs in RANKL and IL-17 may be associated with radiographic progression in Japanese patients with early RA...
  67. doi Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
    Hans J P M Koenen
    Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, The Netherlands
    Blood 112:2340-52. 2008
    ..Thus, the data suggest that epigenetic modification underlies the phenomenon of Treg plasticity here described...
  68. ncbi Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes
    M B Teunissen
    Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Invest Dermatol 111:645-9. 1998
    ....
  69. ncbi Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway
    H C Shin
    Laboratoire d Immunologie, Faculté de Pharmacie de Reims, France
    Cytokine 11:257-66. 1999
    ....
  70. ncbi Free, soluble interleukin-17 protein during severe inflammation in human airways
    M Laan
    Dept of Respiratory Medicine and Allergology, Goteborg University, Gothenburg, Sweden
    Eur Respir J 19:534-7. 2002
    ..The significance of interleukin-17 in inflammatory airway diseases therefore deserves further evaluation...
  71. pmc Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells
    Ladislava Sebkova
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via T Campanella, 88100 Catanzaro, Italy
    Infect Immun 72:5019-26. 2004
    ..In H. pylori-colonized gastric epithelial cells, IL-17-induced IL-8 synthesis is associated with and depends at least in part on the activation of ERK 1/2 MAP kinase...
  72. pmc The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models
    Erik Lubberts
    Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:29-37. 2005
    ..Anti-IL-17 cytokine therapy is of interest as an additional new anti-rheumatic strategy for RA, in particular in situations in which elevated IL-17 might attenuate the response to anti-TNF/anti-IL-1 therapy...
  73. ncbi The potential role of interleukin-17 in the immunopathology of periodontal disease
    Keiso Takahashi
    Department of Endodontics, Meikai University School of Dentistry, Saitama, Japan
    J Clin Periodontol 32:369-74. 2005
    ....
  74. pmc Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization
    Tomokazu Mizuno
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    World J Gastroenterol 11:6305-11. 2005
    ..To determine the role of interleukin (IL)-17 in gastric ulcerogenesis...
  75. ncbi Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:639-46. 2007
    ..Our results demonstrate that human T(H)-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens...
  76. pmc Phenotypic and functional features of human Th17 cells
    Francesco Annunziato
    Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
    J Exp Med 204:1849-61. 2007
    ....
  77. ncbi Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases
    Shilpi Agarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 35:515-9. 2008
    ....
  78. pmc Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers
    Kiran Nistala
    University College London, London, UK
    Arthritis Rheum 58:875-87. 2008
    ....
  79. pmc Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
    Joshua D Milner
    Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 452:773-6. 2008
    ..Thus, our data suggest that the inability to produce T(H)17 cells is a mechanism underlying the susceptibility to the recurrent infections commonly seen in HIES...
  80. pmc Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17
    Jeong Seok Nam
    Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, Korea
    Cancer Res 68:3915-23. 2008
    ..Thus, in addition to suppressing immune surveillance, tumor-induced TGF-beta may actively subvert the CD8+ arm of the immune system into directly promoting tumor growth by an IL-17-dependent mechanism...
  81. pmc IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines
    XingWu Zhu
    Academic Unit of Clinical Oncology, University of Nottingham City Hospital Campus, Nottingham NG5 1PB, UK
    Breast Cancer Res 10:R95. 2008
    ..We therefore examined IL-17 protein expression in human breast cancer and modelled its potential biological significance in vitro...
  82. pmc Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 15:883-9. 2009
    The IL23/IL17 pathway is pivotal in the development of chronic mucosal inflammation seen in Crohn's disease (CD). Genetic variants in the IL23R and IL12B have been associated with CD susceptibility...
  83. doi Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients
    Jing Ping Zhang
    State Key Laboratory of Biocontrol, Sun Yat Sen Zhongshan University, Guangzhou, PR China
    J Hepatol 50:980-9. 2009
    ..To characterize IL-17-producing cells, a newly defined T helper cell subset with potent pro-inflammatory properties, in hepatocellular carcinoma (HCC) and to determine their prognostic values...
  84. doi Increased serum interleukin 17 in patients with systemic lupus erythematosus
    Xue Fei Zhao
    Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, People s Republic of China
    Mol Biol Rep 37:81-5. 2010
    ..However, no associations of serum IL-17 level with disease manifestations were found. Therefore, further studies are required to confirm this preliminary data...
  85. pmc Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t
    Maha Ayyoub
    Institut National de la Sante et de la Recherche Medicale, Unite 892, Centre Rene Gauducheau, 44800 Saint Herblain, France
    Proc Natl Acad Sci U S A 106:8635-40. 2009
    ....
  86. doi Hypoxia enhances stimulating effect of amyloid beta peptide (25-35) for interleukin 17 and T helper lymphocyte subtype 17 upregulation in cultured peripheral blood mononuclear cells
    YanHong Yin
    Department of Neurology, The First Clinical Medical College, Haerbin Medical University, Haerbin, 150001, China
    Microbiol Immunol 53:281-6. 2009
    ..001). This study provides the first report that IL-17A and Th17 lymphocytes are possibly involved in the immune pathogenesis caused by Abeta peptide (25-35). Hypoxia may enhance this response independently of time...
  87. pmc The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 4:e5903. 2009
    ..Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc...
  88. pmc The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans
    Kellie A Charles
    Centre for Cancer and Inflammation, Institute of Cancer, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, United Kingdom
    J Clin Invest 119:3011-23. 2009
    ..We conclude that chronic production of TNF-alpha in the tumor microenvironment increases myeloid cell recruitment in an IL-17-dependent manner that contributes to the tumor-promoting action of this proinflammatory cytokine...
  89. pmc Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells
    E de Jong
    Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, Meibergdreef, AZ Amsterdam, The Netherlands
    Clin Exp Immunol 159:148-58. 2010
    ..In this paper, we review the data regarding the generation of human Th17 cells in vitro and the evidence that this effector population is important in human disease states...
  90. pmc IL-17 contributes to angiogenesis in rheumatoid arthritis
    Sarah R Pickens
    Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 184:3233-41. 2010
    ..These observations identify a novel function for IL-17 as an angiogenic mediator in RA, supporting IL-17 as a therapeutic target in RA...
  91. doi IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation
    Lucie Roussel
    Meakins Christie Laboratories, University Heath Centre Research Institute, Montreal, Quebec, Canada
    J Immunol 184:4531-7. 2010
    ..Therefore, preventing neutrophil recruitment by blocking the action of IL-17 on endothelial cells may prove to be highly beneficial in diseases in which neutrophilic inflammation plays a key role...
  92. doi The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis
    Jiehua Chen
    Division of Respiratory Medicine, Children s Hospital of Chongqing Medical University, Chongqing, 400014, China
    J Clin Immunol 30:539-45. 2010
    ..We investigated the association between single-nucleotide polymorphism (SNP) of IL-17 (rs2275913, IL-17 G-152A) and asthma-related traits. Its effect on IL-17 production was also attractive...
  93. ncbi The role of T-helper 17 (Th17) cells in patients with medulloblastoma
    P Zhou
    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
    J Int Med Res 38:611-9. 2010
    ..The results indicate that Th17 cells may contribute to medulloblastoma pathogenesis...
  94. pmc Host defense mechanisms in secondary syphilitic lesions: a role for IFN-gamma-/IL-17-producing CD8+ T cells?
    Georg Stary
    Department of Dermatology, Division of Immunology, Allergy, and Infectious Diseases DIAID, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Am J Pathol 177:2421-32. 2010
    ....
  95. doi Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease
    M Brodlie
    Applied Immunobiology and Transplantation Group, Institute of Cellular Medicine, Newcastle University, and Department of Cardiopulmonary Transplantation, Newcastle upon Tyne Hospitals NHS Foundation Trust, Sir William Leech Centre for Lung Research, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK
    Eur Respir J 37:1378-85. 2011
    ..IL-17 increases production of pro-neutrophilic mediators by CF epithelial cells, suggesting potential for a positive feedback element in airway inflammation...
  96. doi A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT
    J L Espinoza
    Department of Hematology and Oncology, Kanazawa University Hospital, Kanazawa, Japan
    Bone Marrow Transplant 46:1455-63. 2011
    ..75-45.72; P=0.09), as well as a significantly increased risk for chronic GVHD (HR, 3.86; 95% CI, 1.29-11.59; P=0.02). These results suggest an association of the 197A genotype in the recipient side with the development of acute GVHD...
  97. pmc Interleukin-17 contributes to the pathogenesis of autoimmune hepatitis through inducing hepatic interleukin-6 expression
    Li Zhao
    Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai, China
    PLoS ONE 6:e18909. 2011
    ..Blocking the signaling pathway and interrupting the positive feedback loop are potential therapeutic targets for autoimmune hepatitis...
  98. doi IL-17 boosts proinflammatory outcome of antiviral response in human cells
    Grigory Ryzhakov
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, London W6 8LH, UK
    J Immunol 187:5357-62. 2011
    ..Moreover, this synergy was blocked by an IκB kinase inhibitor, BAY 11-7082. These findings shed light on the molecular mechanisms behind IL-17-dependent immunopathology observed in viral infections...
  99. pmc cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus
    Thomas Rauen
    Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 286:43437-46. 2011
    ..Our findings demonstrate an extended role for CREMα in the immunopathogenesis of SLE because it contributes to increased expression of IL-17A...
  100. pmc IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Crit Care 15:R254. 2011
    b>Interleukin 17A (IL17A) plays a key role in host defense against microbial infection including Gram-positive bacteria...
  101. doi IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma
    Tomomitsu Miyagaki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Cancer Res 17:7529-38. 2011
    ..In this study, we investigated expression levels of T(H)22- and T(H)17-related molecules in lesional skin and sera isolated from patients with CTCL...

Research Grants64

  1. IL-23 / Il-17 and Lung Host Defense
    Jay Kolls; Fiscal Year: 2009
    ..Our hypothesis predicts that IL-17R signaling by lung parenchymal cells is required for production of G-CSF and optimal CXC chemokine production and subsequent neutrophil recruitment in response to experimental K. pneumoniae infection. ..
  2. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Interleukin-17 can cause lung inflammation and asthma. This project is to indentify drugs that can inhibit IL-17 and lung inflammation. ..
  3. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..Therefore, this study is important because it is novel and it will permit us to develop effective therapies to prevent it. (End of Abstract) ..
  4. MARK DOUGLAS OKUSA; Fiscal Year: 2014
    ..inhibition of cells in the dendritic cell (DC)/natural killer T (NKT) cell pathway as well as the downstream IL17 pathway and not from some other mechanism that is unmasked in mice deficient in IgM...
  5. Trim32 Regulation of Piasy in Skin Homeostasis
    Molly F Kulesz-Martin; Fiscal Year: 2013
    ..The CCL20 induction by TNFa and IL17 cytokines is mediated through the activation of NF-kB...
  6. Sam T Hwang; Fiscal Year: 2016
    ..T cells (DETC), accumulates in murine epidermis following exposure to IL23 and is a major producer of IL22 and IL17 in murine epidermis...
  7. GINGIVA DERIVED MSCS: ROLE IN IMMUNOMODULATION AND TISSUE REGENERATION
    Yufang Shi; Fiscal Year: 2013
    ..of skin derived MSCs were tightly regulated by the local inflammatory niche mediated by the autocrine/paracrine IL17/IL6 axis, and therapeutic approaches targeting these distinct niche components resulted in suppression of excessive ..
  8. Ragini Vittal; Fiscal Year: 2015
    ..The results of this research promise the identification of a novel biomarker for patients with predisposition to IPF and OB and to demonstrate the feasibility of developing novel treatment strategies for IPF and OB. ..
  9. Fcgamma mediated regulation of dendritic cell function
    Kavita Dhodapkar; Fiscal Year: 2012
    ..Our preliminary data suggests that Fc?R matured DCs have the ability to activate IL17 producing CD4 as well as CD8 T cells in humans...
  10. Thalachallour Mohanakumar; Fiscal Year: 2015
    ..self-Ags both pre- and post-LTx who developed BOS and to determine;a) cellular immune responses and cytokines (IFN, IL17 and IL10) produced following stimulation with either allo or self-Ag (K?1T, ColV), and b) whether the sera will ..
  11. Deming Sun; Fiscal Year: 2016
    ..between ?? and ?? T cells and determine the role of ?? T cell subsets in immunoregulation on generation of IL17+ uveitogenic T cells...
  12. IANNIS ELIAS ADAMOPOULOS; Fiscal Year: 2015
    ..Detailed understanding of these cellular and molecular interactions will yield insights into regulation of arthritis that can be exploited for therapeutic interventions. ..
  13. Hepatic lymphocytes and fatty liver disease
    Michael D Wheeler; Fiscal Year: 2010
    ..Moreover, the FABP5 isoform is linked to IL17 regulation, a cytokine which was recently shown to be involved alcoholic liver disease...
  14. Alessandro Sette; Fiscal Year: 2016
    ..However, IFN? production was associated with allergic rhinitis and IL17 with allergic asthma...
  15. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..Project 2 will examine the mechanisms by which endothelium selectively regulates recruitment of the IL17- and IFN-y producing subsets of T lymphocytes into tissues...
  16. Influence of Chemokine Receptors on T Cell Cytokine Profiles in Skin
    Robert C Fuhlbrigge; Fiscal Year: 2013
    ..a psoriasis-like cytokine environment, generating populations of antigen-specific T cells that express IFN3 or IL17, but not common TH2-associated cytokines...
  17. George C Tsokos; Fiscal Year: 2016
    ..IL-17 production on the other hand is increased in SLE patients and mice and IL17-producing cells invade the kidney in patients with lupus nephritis...
  18. Regulation of Th17 cells by the Fyn Tyrosine Kinase
    Paul L Stein; Fiscal Year: 2013
    ..help provide insight into whether constant inhibition of Fyn is needed to maintain the Foxp3+ cells and reduced IL17 or whether transient inhibition is sufficient to maintain the unusual TH17 cells that have elevated Foxp3 and ..
  19. Endothelial regulation of IL17 producing T effector cell migration
    MARIA PILAR ALCAIDE ALONSO; Fiscal Year: 2013
    ..abstract_text> ..
  20. Humanized Transgenic Mice Reproduce the Disease Evolution in Severe RA
    Grete Sonderstrup; Fiscal Year: 2010
    ..test the effects of 1) anti-TNF1 blockade (an already well- established treatment in humans with RA), and 2) anti-IL17 blockade on arthritis progression in the new model...
  21. Zihai Li; Fiscal Year: 2016
    ..observed a significant attenuation of inflammation-associated colon cancer and a concurrent reduction of IL23 and IL17. We thus hypothesize that gp96 provide a crucial link for multiple processes including inflammation, tissue ..
  22. Sergio A Lira; Fiscal Year: 2015
    ..the role of the transcription facto IRF8 (ICSBP) on Th17 differentiation (acting as a negative regulator of IL17 production and ROR?t function) and its role in IBD pathogenesis...
  23. Ameae M Walker; Fiscal Year: 2015
    ..to achieve these specific aims, with mechanistic interrogation enhanced by the addition of Rag1-/-, IL-10 null, IL17 receptor A null, or four core genotype mice as foster recipients of the milk. Congenic CD45.1 and CD45...
  24. GPR30-induced Tregs: a therapeutic approach to reversing colitis
    Ryan Brunsing; Fiscal Year: 2012
    ..inflammation, I have developed the following hypothesis: GPR30 signaling drives the differentiation of an CD4+IL10+IL17+ regulatory T cell population that will localize to the gut mucosa to suppress T cell-mediated colonic inflammation...
  25. Thalachallour Mohanakumar; Fiscal Year: 2016
    ..with self reactive T cells and Abs, c) mechanism by which Abs to MHC induce autoimmunity including the role of IL17 in this process, and d) the signaling cascades following ligation of autoantigen K-11 tubulin with its specific Ab ..
  26. MARK DOUGLAS OKUSA; Fiscal Year: 2016
    ..shown that DCs can initiate immune responses following kidney IRI by activating natural killer T cells via the IL23/IL17 pathway. Abrogating this process, e.g. by adenosine 2a receptor (A2aR) agonist administration, attenuates injury...
  27. Chella S David; Fiscal Year: 2014
    ..mice was mediated by anti-inflammatory IFN3, while disease exacerbating effect of DQ8 molecule was mediated by IL17. Based on these observations, we hypothesize that epistatic interaction between HLA-DR and -DQ genes play an ..
  28. Studies on the role of IL-23p19/IL-17 cascade in the pathogenesis of acute GVHD
    JOHN SECORD THOMPSON; Fiscal Year: 2012
    ..The third objective is to determine the relative roles of the IL-23/IL17-21-22 cascade versus the TNF1-IL-12-IL-6 cascade in the pathology of aGVHD...
  29. Adam Lacy-Hulbert; Fiscal Year: 2015
    ..how [unreadable]v integrins expressed by DCs regulate Th17 cell differentiation, particularly the generation of IL17/ IFN-?-expressing cells associated with autoimmunity...
  30. Shuang Chen; Fiscal Year: 2016
    ..These studies thus may provide potential novel molecular targets to prevent infection-mediated disease progression. ..
  31. IL17 RECEPTOR VARIANTS IN INTESTINAL EPITHELIAL CELLS
    Hans Christian Reinecker; Fiscal Year: 2002
    ..The purpose of our experiments will be to provide an increased understanding of the signal transduction of IL-17 ligand-receptor system and its role in regulation of human intestinal epithelial cell function. ..
  32. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..This work has the capacity to fundamentally alter our perceptions of the biology of GVHD and offer new avenues for therapy. ..
  33. Endothelial regulation of IL17 producing T effector cell migration
    MARIA PILAR ALCAIDE ALONSO; Fiscal Year: 2010
    ..Distinctly labeled Th17 and Th1 cells will be transferred into different mouse inflammatory models and their migration in the host mice will be analyzed by several quantitative techniques. (End of Abstract) ..
  34. Samithamby Jeyaseelan; Fiscal Year: 2016
    ....
  35. Liang Zhou; Fiscal Year: 2014
    ..Understanding the differentiation of Th17 and Treg cells at molecular levels will shed light on the disease pathogenesis and may eventually provide novel means for treating human infectious and autoimmune diseases. ..
  36. Elena V Galkina; Fiscal Year: 2015
    ....
  37. The Role of the TH17 cells in the pathogenesis of EAE
    A M Rostami; Fiscal Year: 2013
    ..This proposal will test the hypothesis that Th-17 cells drive the inflammation of the central nervous system (CNS) by secreting two inflammatory mediators, IL-17 and GM-CSF that act on CNS cells to initiate the disease. ..
  38. HOLLY MARIE SCOTT ALGOOD; Fiscal Year: 2016
    ..pylori infection, these experiments will contribute to our understanding of the immune pathology associated with mucosal infections and immune- mediated diseases, such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis. ..
  39. Aging and novel therapeutic interventions in periodontal disease
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2010
    ..Our objective is to therapeutically exploit Del-1 to correct age-associated Del-1 deficiency and thereby prevent destructive periodontal inflammation. ..
  40. Vitamin D and the Immune System
    Lawrence Steinman; Fiscal Year: 2012
    ....
  41. Edith Porter; Fiscal Year: 2014
    ..Last, not least, this research may lead to the discovery of novel virulence factors of pathogenic microbes that circumvent host defenses mediated by antimicrobial lipids in the respiratory tract and on other mucosal surfaces. ..
  42. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  43. Senad Divanovic; Fiscal Year: 2016
    ..The goal of this application is to gain a clear mechanistic understanding of the role of IL-17 axis in the pathogenesis of NASH. The long-term goal of this program is to identify novel preventive and therapeutic strategies for NALFD. ..
  44. Regulation of monocyte recruitment and function by the IL-23/IL-17 axis
    Rance E Berg; Fiscal Year: 2013
    ..The data obtained from these studies may lead to therapeutic options aimed at regulating monocyte function during infectious and other disease states. ..
  45. NICOLE LEANNE WARD; Fiscal Year: 2016
    ..This work will provide the basis and justification for future work exploring the potential of targeting IL-17C or IL-17RE for therapeutic development for the treatment of psoriasis. ..
  46. An Activity-Based Assay to Screen for PRMT1 Inhibitors
    Kerri A Mowen; Fiscal Year: 2013
    ..Since aberrant PRMT1 activity has been associated with cardiovascular, malignant, infectious, and autoimmune disease, it may be a viable therapeutic target for several indications. ..
  47. Development of RORgt Immunomodulators Targeting the TH17 Axis in IBD
    Gordon Alton; Fiscal Year: 2013
    ..This will ultimately enable subsequent IND-enabling studies and clinical trials. ..
  48. Jay K Kolls; Fiscal Year: 2016
    ..We have identified a novel T-cell population that plays a critical role in defense against pneumonia. This application will explore how these cells are generated and how they control host defense in the lung. ..
  49. Klaus F Ley; Fiscal Year: 2016
    ..PF4 or other molecules investigated here may emerge as targets for prevention or therapy of atherosclerosis and its complications. ..
  50. Roles of IL-17-induced gene expression in airway epithelial host defense
    Reen Wu; Fiscal Year: 2013
    ..Such a study will lead to a better understanding of host anti-microbial mechanism that may lead to the development of new therapeutic treatment of bacterial infection in the airways. ..
  51. Chad Steele; Fiscal Year: 2016
    ..murina lung infection and (2) define the role of B cells in the development of local and systemic CD4+ T cell responses during P. murina lung infection. ..
  52. Role of Epithelium in Airway Immunity
    Reen Wu; Fiscal Year: 2012
    ..Our findings regarding the contribution of IL-17A in development of asthma in the non-human primate can be directly extrapolated towards identification of candidate drugs for the prevention of childhood asthma. ..
  53. Reporting IL-17 in Type 1 Diabetes
    LINDA MAC PHERSON BRADLEY; Fiscal Year: 2012
    ..The ability to identify changes in the development of Th17 cells and their functions will facilitate the design of appropriate strategies to control autoaggressive CD4 cells and provide new insights into the biology of Th17 cells. ..
  54. George Scott Worthen; Fiscal Year: 2016
    ....
  55. Daniela Cihakova; Fiscal Year: 2015
    ....
  56. Transcriptional Regulation in the IL17A-IL17F Locus
    ANTONY RAUBITSCHEK; Fiscal Year: 2011
    ....
  57. Barry T Rouse; Fiscal Year: 2016
    ..The final Aim will be to use drug combinations that target different steps in SK pathogenesis which are expected to have improved efficacy compared to single therapies to control disease severity and mediate tissue healing. ..
  58. John T Li; Fiscal Year: 2016
    ..Li's career development. This research will form the basis for translational studies in pediatric patients with ALI, to be proposed in an R01 grant application before the end of the K08 award period. ..
  59. William M Ridgway; Fiscal Year: 2016
    ..We submit that use of our unique murine constructs and our rigorous dissection of the mechanism of autoimmune cholangitis in this model will provide important clues towards successful modulation of human PBC. ..
  60. HEATHER RAQUEL CONTI; Fiscal Year: 2015
    ..This application will study the mechanism of IL-17R signaling in the salivary gland, and how this contributes to protection against disease. ..
  61. KRISTIN LEIGH MOFFITT; Fiscal Year: 2015
    ..Further characterization of candidate proteins and elucidation of the mechanism of immunity they elicit are critical to advance the development of a protein subunit vaccine that prevents colonization. ..
  62. TERRY LYNN MOORE; Fiscal Year: 2016
    ..Since Syk is a therapeutic target for autoinflammatory disease, our studies will further enhance the development of such therapeutic targets for SLE and other autoimmune diseases. ..
  63. Steven F Ziegler; Fiscal Year: 2016
    ..Together the completion of this study will not only delineate the function of Th17/g cells in autoimmunity but also determine the mechanisms by which these cells are generated and can be regulated in mice and humans. ..
  64. Regulation of Il-17A Expression with RSV Infection During Allergic Inflammation
    Dawn C Newcomb; Fiscal Year: 2010
    ..Defining the mechanisms by which RSV-infection on an allergic background induces lung IL-17A production may provide potential therapeutic targets for reducing RSV-induced asthma exacerbations. ..