IL 15

Summary

Gene Symbol: IL 15
Description: interleukin 15
Alias: IL-15, interleukin-15
Species: human

Top Publications

  1. pmc Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
    J G Giri
    Immunex Research and Development Corporation, Seattle, WA 98101
    EMBO J 13:2822-30. 1994
  2. ncbi Promoter sequence, exon:intron structure, and synteny of genetic location show that a chicken cytokine with T-cell proliferative activity is IL2 and not IL15
    P Kaiser
    Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Immunogenetics 49:26-35. 1999
  3. ncbi Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation
    Raweewan Hoontrakoon
    Department of Pediatrics, Division of Allergy and Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Cell Mol Biol 26:404-12. 2002
  4. pmc Apoptosis of peripheral blood lymphocytes in patients with juvenile idiopathic arthritis
    E Smolewska
    Department of Paediatric Cardiology, Institute of Paediatrics, Medical University of Lodz, Poland
    Ann Rheum Dis 62:761-3. 2003
  5. ncbi IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities
    Zane Orinska
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany
    Nat Med 13:927-34. 2007
  6. pmc IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway
    Stephan R Krutzik
    Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, CA 90095, USA
    J Immunol 181:7115-20. 2008
  7. ncbi IL-15 induces type 1 and type 2 CD4+ and CD8+ T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12 / IL-4 stimulation in vitro
    Wanda Niedbala
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, Scotland, GB
    Eur J Immunol 32:341-7. 2002
  8. ncbi Expression of type 1 (interferon gamma) and type 2 (interleukin-13, interleukin-5) cytokines at distinct stages of natural killer cell differentiation from progenitor cells
    Matthew J Loza
    The Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    Blood 99:1273-81. 2002
  9. doi Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1
    Rasheed Ahmad
    Laboratory of Immunovirology and Viral and Immune Diseases Program, Ste Justine Hospital Research Center and Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, QC, Canada
    Blood 112:2360-8. 2008
  10. ncbi IL-15 is elevated in serum patients with type 1 diabetes mellitus
    Sebastian Kuczyński
    Department of Pharmacology, Poznan University of Medical Sciences, Poznan 60 806, Poland
    Diabetes Res Clin Pract 69:231-6. 2005

Research Grants

  1. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2012
  2. Type 1 Diabetes Mouse Resource (T1DR)
    David V Serreze; Fiscal Year: 2012
  3. Jorg J Goronzy; Fiscal Year: 2015
  4. Hans Schreiber; Fiscal Year: 2016
  5. KARIN L GAENSLER; Fiscal Year: 2014
  6. Immunity and the pathogenesis of abdominal aortic aneurysms
    JOHN HUNT LILLVIS; Fiscal Year: 2012
  7. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
  8. Novel dominant-negative HSV-2 recombinant viral vaccines
    Feng Yao; Fiscal Year: 2011
  9. Vaccination with IL-15 DC to Generate Melanoma-specific Protective Memory T Cells
    Anna Karolina Palucka; Fiscal Year: 2013
  10. Costica Aloman; Fiscal Year: 2015

Detail Information

Publications201 found, 100 shown here

  1. pmc Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
    J G Giri
    Immunex Research and Development Corporation, Seattle, WA 98101
    EMBO J 13:2822-30. 1994
    ..The differential ability of some cells to bind and respond to IL-2 and IL-15 implies the existence of an additional IL-15-specific component...
  2. ncbi Promoter sequence, exon:intron structure, and synteny of genetic location show that a chicken cytokine with T-cell proliferative activity is IL2 and not IL15
    P Kaiser
    Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Immunogenetics 49:26-35. 1999
    ..A Taq I polymorphism was identified which enabled chicken IL2 to be mapped to chromosome 4, linked to ANX5, with synteny with mouse chromosome 3 and human chromosome 4. This is the first non-mammalian cytokine gene to be mapped...
  3. ncbi Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation
    Raweewan Hoontrakoon
    Department of Pediatrics, Division of Allergy and Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Cell Mol Biol 26:404-12. 2002
    ..Thus, our results suggest that IL-15, either alone or in combination with TNF-alpha, may perpetuate allergic inflammation by reduction of spontaneous eosinophil apoptosis through autocrine production of GM-CSF and NF-kappaB activation...
  4. pmc Apoptosis of peripheral blood lymphocytes in patients with juvenile idiopathic arthritis
    E Smolewska
    Department of Paediatric Cardiology, Institute of Paediatrics, Medical University of Lodz, Poland
    Ann Rheum Dis 62:761-3. 2003
    ..Recent data suggested that abnormalities in mechanisms regulating apoptosis may have a role in the development of the rheumatoid process...
  5. ncbi IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities
    Zane Orinska
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany
    Nat Med 13:927-34. 2007
    ..Our results identify an unexpected breach in MC-dependent innate immune defenses against sepsis and suggest that inhibiting intracellular IL-15 in MCs may improve survival from sepsis...
  6. pmc IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway
    Stephan R Krutzik
    Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, CA 90095, USA
    J Immunol 181:7115-20. 2008
    ..Therefore, IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway...
  7. ncbi IL-15 induces type 1 and type 2 CD4+ and CD8+ T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12 / IL-4 stimulation in vitro
    Wanda Niedbala
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, Scotland, GB
    Eur J Immunol 32:341-7. 2002
    b>Interleukin 15 (IL-15) is a pleiotropic cytokine produced principally by monocytes and affects both innate and acquired immunity...
  8. ncbi Expression of type 1 (interferon gamma) and type 2 (interleukin-13, interleukin-5) cytokines at distinct stages of natural killer cell differentiation from progenitor cells
    Matthew J Loza
    The Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    Blood 99:1273-81. 2002
    ....
  9. doi Requirement of TLR2-mediated signaling for the induction of IL-15 gene expression in human monocytic cells by HSV-1
    Rasheed Ahmad
    Laboratory of Immunovirology and Viral and Immune Diseases Program, Ste Justine Hospital Research Center and Department of Microbiology and Immunology, Faculty of Medicine, University of Montreal, QC, Canada
    Blood 112:2360-8. 2008
    ....
  10. ncbi IL-15 is elevated in serum patients with type 1 diabetes mellitus
    Sebastian Kuczyński
    Department of Pharmacology, Poznan University of Medical Sciences, Poznan 60 806, Poland
    Diabetes Res Clin Pract 69:231-6. 2005
    ....
  11. pmc HIV-1 Nef protein inhibits the in vitro induction of a specific antibody response to Candida albicans by an early up-regulation of IL-15 production
    L Giordani
    Department of Immunology, Istituto Superiore di Sanita, Rome, Italy
    Clin Exp Immunol 122:358-63. 2000
    ..A better comprehension of this phenomenon may be important for unravelling some aspects of the B cell defects in HIV infection...
  12. ncbi HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokines
    Marco Vitale
    Department of Anatomy, Pharmacology and Forensic Medicine, Ospedale Maggiore, University of Parma, Italy
    Br J Haematol 120:337-43. 2003
    ..The property of p17 to increase the production of TNF-alpha and IFN-gamma might be a mechanism used by HIV-1 to modulate the immune system to support its replication and spreading...
  13. ncbi IL-15-mediated induction of LFA-1 is a late step required for cytotoxic differentiation of human NK cells from CD34+Lin- bone marrow cells
    Isabel Barao
    Department of Microbiology, Veterans Affairs Medical Center, School of Medicine, University of Nevada, Reno, NV 89509, USA
    J Immunol 171:683-90. 2003
    ..The efficacy after only 1 wk of IL-15 administration is a positive practical feature that may apply to human therapy...
  14. ncbi HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets
    Maria Giovanna Quaranta
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    FASEB J 21:2323-34. 2007
    ..Our findings suggest that the Nef-induced dysregulation in the DC/NK cell crosstalk may represent a potential mechanism through which HIV escapes innate immune surveillance...
  15. ncbi Induction of interleukin-15 production by HIV-1 nef protein: a role in the proliferation of uninfected cells
    M G Quaranta
    Department of Immunology, Istituto Superiore di Sanita, Rome, Italy
    Exp Cell Res 250:112-21. 1999
    ..Our results might suggest that Nef enhances the rate of viral replication by a novel mechanism involving the production of IL-15...
  16. ncbi Interleukin-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors: role of Mcl-1 and decreased activity of caspase-3 and caspase-8
    Amélie Bouchard
    INRS Institut Armand Frappier, Universite du Quebec, Pointe Claire, Canada
    J Leukoc Biol 75:893-900. 2004
    ..We conclude that IL-15 delays human neutrophil apoptosis by intracellular events and not via extracellular factors...
  17. pmc Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
    J G Giri
    Immunex Research and Development Corporation, Seattle, WA 98101, USA
    EMBO J 14:3654-63. 1995
    ..IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2...
  18. ncbi Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
    K H Grabstein
    Immunex Research and Development Corporation, Seattle, WA 98101
    Science 264:965-8. 1994
    ..Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor...
  19. ncbi Interaction of IL-15 with the shared IL-2 receptor beta and gamma c subunits. The IL-15/beta/gamma c receptor-ligand complex is less stable than the IL-2/beta/gamma c receptor-ligand complex
    J L de Jong
    Department of Human Oncology, University of Wisconsin, Madison 53792, USA
    J Immunol 156:1339-48. 1996
    ..This result was identical for both surface-iodinated YT cells and immunoprecipitates that were probed for IL-2R beta and IL-2R gamma c on Western blots...
  20. ncbi Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines
    R Meazza
    Instituto Nazionale per la Ricerca sul Cancro, Genova Italy
    Oncogene 12:2187-92. 1996
    ..A possible functional role of IL-15, different from 'IL-2-like' activity, in human tumours, is suggested...
  21. pmc Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides
    Y Tagaya
    Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 94:14444-9. 1997
    Two isoforms of human interleukin 15 (IL-15) exist...
  22. ncbi Control of homeostasis of CD8+ memory T cells by opposing cytokines
    C C Ku
    Howard Hughes Medical Institute, Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Science 288:675-8. 2000
    ..This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2...
  23. ncbi The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15
    G Kurys
    Metabolism Branch, NCI, National Institutes of Health and the Laboratory of Cell Biochemistry and Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1374, USA
    J Biol Chem 275:30653-9. 2000
    ..In terms of a more positive role, we propose that intracellular infection may relieve the burdens on translation and intracellular trafficking to yield effective IL-15 expression...
  24. ncbi Increased IL-15 production of muscle cells in polymyositis and dermatomyositis
    Tomoko Sugiura
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Int Immunol 14:917-24. 2002
    ..Blocking of IL-15 production might be of therapeutic value in PM/DM...
  25. ncbi Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2
    Mariola Kurowska
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    J Immunol 169:1760-7. 2002
    ..Thus, we have demonstrated that a distinctive phenotype of RA FLS, i.e., persistent activation, proliferation, and resistance to apoptosis, is related to the autocrine activation of IL-15Rs by FLS-derived IL-15...
  26. ncbi IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells
    Manabu Yanagita
    Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Japan
    Biochem Biophys Res Commun 297:329-34. 2002
    ..The enhanced NO production by IL-15 was inhibited by AMT, an iNOS-specific inhibitor. These results suggest that IL-15 is a potent regulator of iNOS expression by HGEC and involved in innate immunity in the mucosal epithelium...
  27. ncbi Regulation of lymphoid homeostasis by interleukin-15
    James P Lodolce
    Department of Medicine, Ben May Institute for Cancer Research, University of Chicago, 5841 S Maryland Ave MC 6084, Chicago, IL 60637, USA
    Cytokine Growth Factor Rev 13:429-39. 2002
    ..IL-15 has been shown to regulate the homeostasis of both innate and adaptive immune cells, and this review will discuss several ways in which this pleiotropic cytokine may support lymphoid homeostasis...
  28. ncbi Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity
    June Eisenman
    Department of Protein Chemistry, Immunex Corporation, 51 University Street, Seattle, WA, 98101, USA
    Cytokine 20:121-9. 2002
    ..These data show that hu IL-15 may be used in mouse model systems, however care must be taken when comparing the efficacy and toxicity of cytokines across species...
  29. ncbi Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules
    Julien Giron-Michel
    U 506 INSERM, Batiment Lavoisier, Hopital Paul Brousse, 94807 Villejuif, France
    Blood 102:109-17. 2003
    ....
  30. ncbi IL-15 promotes the survival of naive and memory phenotype CD8+ T cells
    Marion Berard
    Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom
    J Immunol 170:5018-26. 2003
    ..These results show that IL-15 has multiple effects on CD8 T cells and possesses the potential to regulate the life span of naive as well as memory CD8(+) T cells...
  31. ncbi IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro
    Nuno L Alves
    Laboratory for Experimental Immunology, G1 133, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Blood 102:2541-6. 2003
    Recent studies in mice have shown that although interleukin 15 (IL-15) plays an important role in regulating homeostasis of memory CD8+ T cells, it has no apparent function in controlling homeostatic proliferation of naive T cells...
  32. ncbi Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection
    Masahisa Jinushi
    Osaka University Graduate School of Medicine, Department of Molecular Therapeutics, Suita, Osaka, Japan
    J Immunol 171:5423-9. 2003
    ....
  33. pmc Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model
    Louise S Villadsen
    Department of Dermatology, Gentofte University Hospital, Copenhagen, Denmark
    J Clin Invest 112:1571-80. 2003
    ..These results obtained with this IL-15-specific mAb support an important role for IL-15 in the pathogenesis of psoriasis...
  34. pmc IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells
    Christopher A Klebanoff
    Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 101:1969-74. 2004
    ..These results provide several avenues for improving adoptive immunotherapy of cancer in patients...
  35. ncbi Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling
    Graham G Neely
    Department of Medical Sciences, University of Calgary, Calgary, Alberta, Canada
    J Immunol 172:4225-34. 2004
    ..Thus, the current study has established that cell surface IL-15 is more than just a ligand; it can function as a receptor and participate in reverse signaling that results in cellular adhesion and production of inflammatory cytokines...
  36. ncbi Multilocus haplotype analyses reveal association between 5 novel IL-15 polymorphisms and asthma
    Thorsten Kurz
    University Children s Hospital, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
    J Allergy Clin Immunol 113:896-901. 2004
    ..The observations suggest a potential role for this cytokine in a variety of pathologic conditions, including T(H)1-mediated and T(H)2-mediated inflammatory diseases...
  37. ncbi Serum interleukin-15 concentration in patients with essential hypertension
    Masaharu Kaibe
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Hypertens 18:1019-25. 2005
    ..However, the influence of systemic IL-15 on cardiovascular disease is still unclear. Therefore, we designed clinical investigations to clarify the relationship between cardiovascular complications and serum IL-15 levels...
  38. ncbi Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins
    Erwan Mortier
    INSERM, U601, Groupe de Recherche Cytokines et Récepteurs, Institut de Biologie, Nantes F 44093, France
    J Biol Chem 281:1612-9. 2006
    ..Such hyper-IL-15 fusion proteins appear to constitute potent adjuvants for the expansion of lymphocyte subsets...
  39. ncbi Confirmation of association of IL-15 with pediatric asthma and comparison of different controls
    S Bierbaum
    University Children s Hospital, University of Freiburg, Freiburg, Germany
    Allergy 61:576-80. 2006
    ..We were interested in whether association of asthma with IL-15 holds in a second population. Furthermore, we sought to investigate the effect of different controls...
  40. ncbi Interaction of monocytic cells with respiratory syncytial virus results in activation of NF-kappaB and PKC-alpha/beta leading to up-regulation of IL-15 gene expression
    Jamila Ennaciri
    Laboratory of Immunovirology, Sainte Justine Hospital Research Center, Montreal, QC, Canada
    J Leukoc Biol 81:625-31. 2007
    ..This study, demonstrating the ability of RSV to induce IL-15 expression, might explain, at least in part, the exacerbated, inflammatory response triggered by RSV infection...
  41. ncbi Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population
    Xue Jun Zhang
    Institute of Dermatology and Department of Dermatology at No 1 Hospital, Anhui Medical University, Hefei, China
    J Invest Dermatol 127:2544-51. 2007
    ..Therefore, we provided early evidence for the important role of IL-15 genetic variants in the pathogenesis of psoriasis, probably by increasing interleukin production and inflammation in the lesions of psoriasis...
  42. ncbi Elucidation of the interleukin-15 binding site on its alpha receptor by NMR
    Nicole A Hanick
    Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305, USA
    Biochemistry 46:9453-61. 2007
    ..Our results predict that the binding surface on IL-15Ralpha involves strands C and D, similar to IL-2Ralpha. The interface, as predicted here, leaves open the possibility of trans-presentation of IL-15 by IL-15Ralpha on an opposing cell...
  43. ncbi The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways
    Daniela de Totero
    Department of Translational Oncology and Medical Oncology C, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Blood 111:517-24. 2008
    ..The knowledge of the signaling pathways regulating CLL cell survival and proliferation may provide new molecular targets for therapeutic intervention...
  44. ncbi High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS
    Gunnar Cario
    Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany
    J Clin Oncol 25:4813-20. 2007
    ....
  45. ncbi Dual roles of IL-15 in maintaining IL-7RalphalowCCR7- memory CD8+ T cells in humans via recovering the phosphatidylinositol 3-kinase/AKT pathway
    Hang Rae Kim
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:6734-40. 2007
    ..Moreover, IL-15 can be useful in reviving impaired proliferative function of such memory CD8(+) T cells with effector functions against infections and tumors via rescuing the PI3K/AKT pathway...
  46. pmc Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway
    Matthew J Lindemann
    Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:14100-8. 2008
    ..Thus, there are intrinsic signaling differences between IL-2 and IL-15 that can be attributed to differences in activation of the PI3K pathway...
  47. pmc How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha
    Erwin H Duitman
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
    Mol Cell Biol 28:4851-61. 2008
    ....
  48. pmc Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome
    Emidio E Pistilli
    Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, 3700 Hamilton Walk, A601 Richards Building, Philadelphia, PA 19140, USA
    Cytokine 43:45-53. 2008
    ..04), and baseline muscle quality (p=0.04). All associations were consistent in showing a potential involvement of the IL-15 pathway with muscle and bone phenotypes and predictors of metabolic syndrome...
  49. pmc Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia
    Jun J Yang
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    JAMA 301:393-403. 2009
    ..Pediatric acute lymphoblastic leukemia (ALL) is the prototype for a drug-responsive malignancy. Although cure rates exceed 80%, considerable unexplained interindividual variability exists in treatment response...
  50. pmc Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15
    Fangming Tang
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 206:707-19. 2009
    ..These results reveal an unrecognized link between NKG2D and tissue inflammation, which may underlie the emerging role of NKG2D in various immunopathological conditions and define new therapeutic targets...
  51. doi Influences of genetic variants in interleukin-15 gene and serum interleukin-15 levels on coronary heart disease
    Cahide Gokkusu
    Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
    Cytokine 49:58-63. 2010
    ..In conclusion, our study supports the hypothesis that genetic variation in IL-15 gene and IL-15 levels influence the risk of CHD. Further studies are needed to confirm our hypothesis...
  52. doi Placental interleukin-15 expression in recurrent miscarriage
    Bettina Toth
    Department of Gynecological Endocrinology and Fertility Disorders, Ruprechts Karls University, Heidelberg, Germany
    Am J Reprod Immunol 64:402-10. 2010
    ..A dysregulation of the cytokine profile could be linked with fetal rejection. This study investigated differences in the expression of the Th1 cytokine interleukin-15 (IL-15) of normal and disturbed pregnancy...
  53. doi Characterization of serum interleukin-15 in healthy volunteers and patients with early arthritis to assess its potential use as a biomarker
    Amalia Lamana
    Rheumatology Service, Hospital Universitario La Princesa, IIS La Princesa, Madrid, Spain
    Eur Cytokine Netw 21:186-94. 2010
    ..Further studies will be necessary to determine whether the clinical evolution or response to treatment of patients with high sIL-15 levels differs...
  54. doi RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells
    M T Zdrenghea
    Dept of Respiratory Medicine, National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma and Centre for Respiratory Infection, Imperial College London, London, UK
    Eur Respir J 39:712-20. 2012
    ..IFN-γ upregulated RSV induction of soluble IL-15 but inhibited induction of MICA. Upregulation of IL-15, MHC I and MICA are likely to be important mechanisms in activating immune responses to RSV by epithelial cells...
  55. pmc The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development
    Iris Castro
    Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Immunol 187:5170-82. 2011
    ..Our findings are consistent with a model whereby low, intermediate, and high CD122 signaling support T(CM) memory survival, T(EM) programming, and terminal T effector cell differentiation, respectively...
  56. pmc Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum
    Cristina Bergamaschi
    Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Blood 120:e1-8. 2012
    ..Analysis of the form of IL-15 present in either normal or lymphodepleted mice agrees with the human data. These results have important implications for development of assays and materials for clinical applications of IL-15...
  57. ncbi Differential expression of interleukin-15, a pro-inflammatory cytokine and T-cell growth factor, and its receptor in human prostate
    A Handisurya
    Department of Urology, University of Vienna, Vienna, Austria
    Prostate 49:251-62. 2001
    ..Pro-inflammatory interleukin (IL)-15 plays a major role in host defense and chronic inflammation by stimulating T-lymphocyte recruitment and growth. Expression of IL-15 and IL-15 receptor (IL-15R) in human prostate was examined...
  58. ncbi Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis
    Hiroki Kuniyasu
    Department of Oncological Pathology, Nara Medical University Cancer Center, Kashihara, Nara 634 8521, Japan
    Clin Cancer Res 9:4802-10. 2003
    ..The purpose of this study was to identify a mediator produced by human colon cancer cells that is responsible for the induction of hyperplasia in the adjacent mucosa...
  59. ncbi The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS
    Maria Giovanna Quaranta
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    FASEB J 20:2198-208. 2006
    ....
  60. ncbi Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease
    Mélika Benahmed
    INSERM U793, Paris, France
    Gastroenterology 132:994-1008. 2007
    ..Our goal has been to investigate why the proinflammatory effects of IL-15 cannot be efficiently controlled by TGF-beta in celiac disease...
  61. doi Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levels
    Michael Boyiadzis
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Biol Blood Marrow Transplant 14:290-300. 2008
    ....
  62. ncbi [Effect of various combinations of IL2, IL12 and IL15 on function of human peripheral blood derived NK cells]
    Xiao Hong Li
    Center of Hematology, PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:918-23. 2009
    ..IL2 and IL15 have synergistic effect on strengthening cytotoxicity of NK cells and promoting cell expansion. However, the main function of IL12 promotes NK cells to secrete IFN-gamma, which plays a role in immunoregulation...
  63. doi Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells
    Bärbel I de Bakker
    Applied Optics Group, Faculty of Science and Technology, MESA Research Institute for Nanotechnology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands
    J Cell Sci 121:627-33. 2008
    Interleukin 2 and interleukin 15 (IL2 and IL15, respectively) provide quite distinct contributions to T-cell-mediated immunity, despite having similar receptor composition and signaling machinery...
  64. doi Interleukin-15 receptor-directed immunotoxins atteunuate disease severity in rat adjuvant arthritis
    Deling Wang
    Key Laboratory of Ministry of Education for Developmental Genes and Human Diseases, School of Basic Medical Sciences, Southeast University, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China
    Mol Immunol 47:1535-43. 2010
    ..In addition, wild-type IL-15-based immunotoxins can be as effective as antagonist mutant IL-15-based immunotoxins in preventing joint inflammation associated with rheumatoid arthritis...
  65. doi Human bone marrow mesenchymal stem cells and chondrocytes promote and/or suppress the in vitro proliferation of lymphocytes stimulated by interleukins 2, 7 and 15
    C Bocelli-Tyndall
    Institute of Surgical Research and Hospital Management and Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Ann Rheum Dis 68:1352-9. 2009
    ....
  66. pmc Essential role of interleukin-15 receptor in normal anxiety behavior
    Xiaojun Wu
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Brain Behav Immun 24:1340-6. 2010
    ..Thus, IL15Rα is essential for normal anxiety-like behavior, but inhibition of gliosis in the fearless IL15Rα knockout mice or IL15 treatment of normal mice did not acutely modulate behavioral performance as tested...
  67. doi Generation of multi-functional antigen-specific human T-cells by lentiviral TCR gene transfer
    M Perro
    Department of Immunology, Division of Infection and Immunity, University College London, Royal Free Hospital, London, UK
    Gene Ther 17:721-32. 2010
    ..The data demonstrate that the combination of lentiviral TCR gene transfer together with IL15/IL21 stimulation can efficiently redirect the antigen specificity of resting primary human T-cells and generate multi-functional T-cells...
  68. ncbi Cloning and expression of feline interleukin 15
    Gregg A Dean
    Department of Molecular Biomedical Sciences, 4700 Hillsborough Street, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Cytokine 29:77-83. 2005
    A cDNA encoding feline interleukin 15 (IL15) was cloned from the lymph node of a cat infected with feline infectious peritonitis virus. The cDNA is 486 bp in length and encodes a protein of 162 amino acids...
  69. ncbi [Ex vivo expansion of highly purified NK cells from human peripheral blood]
    Xiao Hong Li
    Center of Hematology, PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:373-7. 2007
    ..05). It is concluded that high purity of NK cells can be efficiently expanded in culture with IL2 + IL15...
  70. pmc Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal-dependent memory
    Yi He
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Neurosci 30:4725-34. 2010
    ..Consistent with this, IL15Ralpha knock-out mice had increased synaptosomal uptake of (3)H-GABA. Overall, the results show novel functions of a unique cytokine in normal hippocampal activity by regulating GABA transmission...
  71. pmc Effect of IL15 on T cell clonality in vitro and in the synovial fluid of patients with rheumatoid arthritis
    K Masuko-Hongo
    Rheumatology, Immunology and Genetics Program, Institute of Medical Science, St Marianna University, Kawasaki 216 8512, Japan
    Ann Rheum Dis 59:688-94. 2000
    ..Recent studies have suggested that interleukin (IL) 15 induces T cell accumulation in synovial lesions of rheumatoid arthritis (RA). This study aimed at determining whether this cytokine could explain in vivo T cell clonality in RA...
  72. ncbi IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTL
    Peter Dubsky
    Baylor Institute for Immunology Research, Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    Eur J Immunol 37:1678-90. 2007
    ..Therefore, membrane-bound IL-15 might contribute to enhanced priming by IL15-DC. Thus, IL-15 induces myeloid DC that are efficient in priming and maturation of melanoma antigen-specific CTL...
  73. pmc Cerebral microvascular IL15 is a novel mediator of TNF action
    Weihong Pan
    Blood Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Neurochem 111:819-27. 2009
    ..We conclude that the cerebral microvascular IL15 system is a novel inflammatory mediator that transduces the actions of TNF...
  74. doi Functional characterization of interleukin-15 gene transduction into the human natural killer cell line NKL
    W Jiang
    Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University, Jinan, China
    Cytotherapy 10:265-74. 2008
    ..Genetic modification of natural killer (NK) cells is a potential approach to gene-based immunotherapy of cancer. We created human interleukin-15 (hIL-15) gene-modified NKL cells and investigated their functional characterization in vitro...
  75. doi Efficacy of recombinant bacille Calmette-Guérin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis
    Ce Tang
    Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Infect Dis 197:1263-74. 2008
    ..tuberculosis. Thus, rBCG-Ag85B-IL15 vaccination capable of inducing efficient cell-mediated immunity might be used as an effective vaccine for tuberculosis...
  76. ncbi [Effects of IL-21 alone or in combination with IL-15/IL-2 on proliferation and anti-tumor activity of G-CSF-mobilized peripheral blood mononuclear cells in vitro]
    Lan Li
    Department of Hematology and Transplantation, Hospital 307, Academy of Military Medical Sciences, Beijing 100071, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:350-4. 2008
    ..peripheral blood mononuclear cells (G-PBMNCs) activated by interleukin 21 (IL-21) alone or in combination with interleukin 15 (IL-15)/interleukin 2 (IL-2) and to evaluate the feasibility and value of tumor immunotherapy with cytokine ..
  77. pmc Immunotherapy: rAAV2 expressing interleukin-15 inhibits HeLa cell tumor growth in mice
    Giou Teng Yiang
    Institute of Biomedical Nutrition, College of Medicine and Nursing, Hung Kuang University, Sha Lu, Taichung, Taiwan
    J Biomed Sci 16:47. 2009
    ..In conclusion, our studies show that human cervical cancers are inhibited on animal model with rAAV2-hIL15 treatment and provide a safer and important reference for human cancer gene therapy...
  78. pmc Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Neurochem 106:313-9. 2008
    Interleukin15 (IL 15) is a proinflammatory cytokine with elevated concentrations in autoimmune diseases involving the periphery (e.g. rheumatoid arthritis) and CNS (e.g. multiple sclerosis)...
  79. ncbi PPARdelta mediates IL15 metabolic actions in myotubes: effects of hyperthermia
    Gemma Fuster
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Int J Mol Med 24:63-8. 2009
    ..The present study also suggests that the effects of IL15 on lipid oxidation could be mediated by PPARdelta...
  80. pmc Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis
    Xiaojun Wu
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Neuroimmunol 223:65-72. 2010
    ..IL15 knockout mice showed heightened susceptibility to EAE with significantly higher scores that were decreased by treatment with IL15. Thus, IL15 improves this CNS autoimmune disorder as a potential therapeutic agent...
  81. ncbi Increased serum levels of interleukin-15 in rheumatoid arthritis with long- term disease
    I Gonzalez-Alvaro
    Rheumatology Department, Hospital Universitario de la Princesa, Madrid, Spain
    Clin Exp Rheumatol 21:639-42. 2003
    ..To study the serum levels of IL-15 in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), seronegative spondyloarthropathies (SSd) and healthy donors...
  82. ncbi Immunity to systemic Salmonella infections
    Pietro Mastroeni
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Curr Mol Med 2:393-406. 2002
    ..Thus, the development of protective immunity to Salmonella infections relies on the cross-talk between the humoral and cellular branches of the immune system...
  83. pmc Potential plasma markers of Type 1 and Type 2 leprosy reactions: a preliminary report
    Mariane M Stefani
    Tropical Pathology and Public Health Institute, Federal University of Goias, GO, Brazil
    BMC Infect Dis 9:75. 2009
    ..This study simultaneously screened plasma factors to identify circulating biomarkers associated with leprosy T1R and T2R among patients recruited in Goiania, Central Brazil...
  84. ncbi Canine X-linked severe combined immunodeficiency. A model for investigating the requirement for the common gamma chain (gamma c) in human lymphocyte development and function
    P J Felsburg
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, USA
    Immunol Res 17:63-73. 1998
    ..2. The pathogenesis of XSCID. 3. Strategies for improving bone marrow transplantation outcome. 4. Development and evaluation of strategies for gene therapy. 5. Human hematopoietic stem cell development...
  85. ncbi Gluten: a two-edged sword. Immunopathogenesis of celiac disease
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, E3 Q, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Springer Semin Immunopathol 27:217-32. 2005
    ..Although long thought to be impossible, recent results suggest that the development of nontoxic wheat varieties may be feasible, which would aid disease prevention and provide an alternative food source for patients...
  86. pmc Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study
    Wilco de Jager
    Department of Pediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 66:589-98. 2007
    ..Although onset and disease course differ, the subtypes of JIA share the occurrence of chronic inflammation of the joints, with infiltrations of immunocompetent cells that secrete inflammatory mediators...
  87. pmc Expression and signaling of novel IL15Ralpha splicing variants in cerebral endothelial cells of the blood-brain barrier
    Xiaojun Wu
    Blood Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Neurochem 114:122-9. 2010
    ..The results show that IL15 signaling in cerebral endothelia is probably an orchestrated effect of all IL15Ralpha splice variants that determine the eventual outcome by differential regulation...
  88. ncbi Does mosaicism of the plasma membrane at molecular and higher hierarchical levels in human lymphocytes carry information on the immediate history of cells?
    Sandor Damjanovich
    Department of Biophysics and Cell Biology, Hungarian Academy of Sciences, University of Debrecen, Debrecen, Hungary
    Immunol Lett 82:93-9. 2002
    ....
  89. pmc Higher constitutive IL15R alpha expression and lower IL-15 response threshold in coeliac disease patients
    D Bernardo
    Mucosal Immunology Laboratory, Instituto de Biología y Genética Molecular IBGM, Universidad de Valladolid CSIC, Valladolid, Spain
    Clin Exp Immunol 154:64-73. 2008
    ..Gliadin-induced IL15 has a lower response threshold in CD patients, leading to the production of other immune mediators and the development of the intestinal lesion, and thus magnifying its effects within the CD intestine...
  90. ncbi New leads in cancer therapeutics: a keynote address
    E Mihich
    Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Medicina (B Aires) 60:4-8. 2000
    ..The latter approach is the main subject of this address...
  91. pmc Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules
    Wen Liu-Mares
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    BMC Proc 1:S126. 2007
    ..We conclude that variation in the genes encoding p50 and c-Rel may play a role in NF-kappaB-related transcription of FAS, IRF1, and CD40...
  92. doi What's next in the pipeline
    F Vincenti
    University of California, San Francisco, Kidney Transplant Service, San Francisco, CA, USA
    Am J Transplant 8:1972-81. 2008
    ..The preclinical pipeline is not only full but promises to address previously neglected targets and fulfill unmet medical needs in transplant therapeutics...
  93. ncbi Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    J Parrish-Novak
    Department of Functional Cloning, ZymoGenetics, Inc, Seattle, Washington 98102, USA
    Nature 408:57-63. 2000
    ....
  94. ncbi Human thymic epithelial cells inhibit IL-15- and IL-2-driven differentiation of NK cells from the early human thymic progenitors
    P T Le
    Department of Cell Biology, Neurobiology, and Anatomy and the Program in Immunology for Aging, Stritch School of Medicine, Loyola University Chicago Medical Center, Maywood, IL 60153, USA
    J Immunol 166:2194-201. 2001
    ....
  95. pmc Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines
    Wolfgang Hueber
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, and Palo Alto VA Health Care System, MC 154R, 3801 Miranda Avenue, Palo Alto, CA 94304, USA
    Ann Rheum Dis 66:712-9. 2007
    ..To identify peripheral blood autoantibody and cytokine profiles that characterise clinically relevant subgroups of patients with early rheumatoid arthritis using arthritis antigen microarrays and a multiplex cytokine assay...
  96. ncbi Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias
    Dejan Juric
    Division of Medical Oncology, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
    J Clin Oncol 25:1341-9. 2007
    ..To identify gene expression patterns and interaction networks related to BCR-ABL status and clinical outcome in adults with acute lymphoblastic leukemia (ALL)...
  97. ncbi Short intensive exercise increases the migratory activity of mesenchymal stem cells
    A Schmidt
    Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf, 50933 Cologne, Germany
    Br J Sports Med 43:195-8. 2009
    ..To answer this question, we analysed the influence of athletes' blood sera on human mesenchymal stem cells (MSC)...
  98. pmc NF-kappa B genes have a major role in inflammatory breast cancer
    Florence Lerebours
    Centre Rene Huguenin, FNCLCC, 35 rue Dailly, 92210, St Cloud, France
    BMC Cancer 8:41. 2008
    ..Given the role of NF-kappaB-related genes in cell proliferation, invasiveness, angiogenesis and inflammation, we postulated that they might be deregulated in IBC...
  99. doi Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis
    S C Wong
    Bone and Endocrine Research Group, Department of Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow, United Kingdom
    Growth Horm IGF Res 18:369-78. 2008
    ..To investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA...
  100. pmc In vivo expression of signaling proteins in reconstituted NK cells
    Selinda J Orr
    Cancer and Inflammation Program, National Cancer Institute Frederick, Frederick MD 21702 USA
    J Immunol Methods 340:158-63. 2009
    ..Constitutively active p110gamma revealed profound effects on NK cell development and function in vivo while p110delta had little effect...
  101. pmc Characterization of the thymic IL-7 niche in vivo
    Nuno L Alves
    Cytokines and Lymphoid Development Unit, Lymphocyte Development Unit, Plate Forme Technologique Centre d Ingénierie Génétique Murine, and Laboratory of Lymphoid Tissue Development, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 106:1512-7. 2009
    ..This IL-7 reporter mouse provides a valuable tool to further dissect the mechanisms that govern thymic IL-7 expression in vivo...

Research Grants32

  1. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2012
    ..Their interactions with the blood-brain barrier largely determine the final outcome of these blood-borne cytokines. ..
  2. Type 1 Diabetes Mouse Resource (T1DR)
    David V Serreze; Fiscal Year: 2012
    ..The mission of the T1DR is to import, re-derive to a high-level health status, curate, genotypically and phenotypically validate, cryopreserve, and distribute mouse stocks of value to the T1D research community. ..
  3. Jorg J Goronzy; Fiscal Year: 2015
    ..abstract_text> ..
  4. Hans Schreiber; Fiscal Year: 2016
    ..With these antibodies, we will make additional CARs (and fusions proteins) to be used in combination with 5E5 to prevent tumor escape. ..
  5. KARIN L GAENSLER; Fiscal Year: 2014
    ..Studies will directly inform the design of a Phase 1 clinical AML vaccine trial at UCSF for patients >60, ineligible for HSCT. ..
  6. Immunity and the pathogenesis of abdominal aortic aneurysms
    JOHN HUNT LILLVIS; Fiscal Year: 2012
    ..abstract_text> ..
  7. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..Understanding the mechanisms by which these factors enhance anti-viral immunity is essential to the development of novel strategies to delay onset and progression of HSV in at risk populations. ..
  8. Novel dominant-negative HSV-2 recombinant viral vaccines
    Feng Yao; Fiscal Year: 2011
    ..The vaccine efficacy of IL15/gB2-expressing CJ2-gD2 in preventing primary and recurrent HSV-2 genital disease will be evaluated in mouse and guinea pig models of HSV-2 intravaginal infection. ..
  9. Vaccination with IL-15 DC to Generate Melanoma-specific Protective Memory T Cells
    Anna Karolina Palucka; Fiscal Year: 2013
    ..Current therapies have the potential to improve outcome in a fraction of patients but are associated with considerable toxicity. Vaccination with melanoma antigen-loaded dendritic cells (DCs) could improve outcomes without toxicity. ..
  10. Costica Aloman; Fiscal Year: 2015
    ..These studies should uncover new pathways to accelerate fibrosis regression, leading to innovative treatments for patients with advanced fibrosis. ..
  11. IL15 AND NATURAL KILLER (NK) CELL FUNCTION
    William Carson; Fiscal Year: 1999
    ....
  12. Potentiating Natural Killer Cell Anti-Myeloma Effects
    Frits van Rhee; Fiscal Year: 2012
    ..This grant proposal describes 3 new ways in which the patient's own immune cells can be used to destroy the cancer. Such treatment may also be useful to treat other cancers. ..
  13. Effie W Petersdorf; Fiscal Year: 2015
    ..The information will aid efforts to optimize transplant outcomes for AFA and API patients, while creating a highly novel and unique resource for continued investigation into the genetic basis of disease. ..
  14. Soluble TCR-IL15 Fusions as Targeted Therapeutics for Cancer
    Peter Rhode; Fiscal Year: 2009
    ..Ultimately, this approach may provide a safer and more effective treatment for patients with cancer than the currently approved immunotherapies. ..
  15. Quantitative modeling of the phenotypic variability of individual T cells and the
    Gregoire Altan-Bonnet; Fiscal Year: 2012
    ..It consists in making and validating theoretical predictions to quantify and control how immune responses emerge as dynamically- and collectively-regulated properties of individual T cells. ..
  16. Jacques Galipeau; Fiscal Year: 2016
    ..In sum, this study will enable us to pursue the characterization of iBregs and GIFT15 protein pharmacological product and will serve as rational for human clinical studies. ..
  17. ONTOGENY OF MEASLES IMMUNITY IN INFANTS
    Ann Arvin; Fiscal Year: 2006
    ..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
  18. ONTOGENY OF MEASLES IMMUNITY IN INFANTS
    Hayley Gans; Fiscal Year: 2009
    ..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
  19. Dendritic cell targeted hepatitis c virus immunotherapy
    Tyler Curiel; Fiscal Year: 2003
    ..that express and secrete DC-targeted NS3. A needle-less and non-toxic immunotherapy would provide a treatment for hepatitis C patients who currently have none. ..
  20. Role of T Cell Immunity in Primate AIDS
    Aftab Ansari; Fiscal Year: 2006
    ....
  21. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..
  22. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  23. THERAPY FOR AIDS CENTRAL NERVOUS SYSTEM LYMPHOMA
    Michael Caligiuri; Fiscal Year: 2002
    ..The limitations of the animal model preclude its use for studying the pathogenesis of AIDS PCNSL. ..
  24. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  25. Aging and thymopoiesis: Changes in stroma, T-presursors
    Phong Le; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  26. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  27. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  28. Recombinant Listeria: A Biologic Vaccine Vector For FIV
    Gregg Dean; Fiscal Year: 2004
    ..These studies will be performed in the FIV/cat model that allows challenge by vaginal exposure to cell-associated and cell-free virus. ..
  29. Interacton of HIV with Toll-like Receptors
    Gregg Dean; Fiscal Year: 2005
    ..Through these studies we will learn if HIV/TLR interaction contribute to the immunodeficiency caused by HIV-1. ..
  30. CYTOKINE RESPONSE IN FIV AND SIV IMMUNODEFICIENCY
    Gregg Dean; Fiscal Year: 2002
    ..ft. of laboratory space, startup funds, access to the central equipment laboratory, and three years of support for a technical assistant. ..
  31. BASIS AND MODULATION OF THE INNATE IMMUNE DEFECT IN FIV
    Gregg A Dean; Fiscal Year: 2010
    ..Together these studies will elucidate the cellular mechanisms that underlie the innate immune defect and investigate potential molecular mechanisms. ..
  32. In vivo significance of T-reg cells during FIV infection
    Gregg Dean; Fiscal Year: 2006
    ..Results from these studies will provide a clinical understanding of Treg function in HIV infection and will guide future approaches to modulate Treg function. ..