IL-10

Summary

Gene Symbol: IL-10
Description: interleukin 10
Alias: CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin-10, T-cell growth inhibitory factor, cytokine synthesis inhibitory factor
Species: human

Top Publications

  1. doi Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β
    Christina E Zielinski
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
    Nature 484:514-8. 2012
  2. pmc Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    Frank A W Verreck
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 101:4560-5. 2004
  3. pmc Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases
    Vincent Plagnol
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 7:e1002216. 2011
  4. doi Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
    Silvia Gregori
    Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Blood 116:935-44. 2010
  5. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
  6. ncbi Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
    Gastroenterology 124:1193-201. 2003
  7. doi The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea
    Jung Mook Kang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 43:420-8. 2009
  8. pmc Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Cancer Causes Control 20:1739-51. 2009
  9. ncbi Interleukin-10 gene promoter polymorphisms influence the clinical outcome of diffuse large B-cell lymphoma
    Ewa Lech-Maranda
    Equipe d Accueil 3737 Pathologie des Cellules Lymphoïdes, Universite Claude Bernard, Lyon, France
    Blood 103:3529-34. 2004
  10. pmc HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells
    Meimei Shan
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS Pathog 3:e169. 2007

Research Grants

  1. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
  2. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    Martha L Slattery; Fiscal Year: 2013
  3. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
  4. Pathway analysis of tuberculosis pathogenesis
    CATHERINE MARIE STEIN; Fiscal Year: 2013
  5. Jonathan Savitz; Fiscal Year: 2016
  6. Daniela Salvemini; Fiscal Year: 2016
  7. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
  8. Aaron W Michels; Fiscal Year: 2016
  9. Thalachallour Mohanakumar; Fiscal Year: 2015
  10. Alexander Miethke; Fiscal Year: 2016

Detail Information

Publications372 found, 100 shown here

  1. doi Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β
    Christina E Zielinski
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
    Nature 484:514-8. 2012
    ..albicans and S. aureus prime TH17 cells that produce either IFN-γ or IL-10, and identify IL-1β and IL-2 as pro- and anti-inflammatory regulators of TH17 cells both at priming and in the effector phase...
  2. pmc Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
    Frank A W Verreck
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Albinusdreef 2, NL 2333 ZA, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 101:4560-5. 2004
    ..Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection...
  3. pmc Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases
    Vincent Plagnol
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 7:e1002216. 2011
    ..Analysis of the TPOA-associated loci in 2,477 cases with Graves' disease identified two new AITD loci (BACH2 and UBASH3A)...
  4. doi Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
    Silvia Gregori
    Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Blood 116:935-44. 2010
    ..Our data indicate that DC-10 represents a novel subset of tolerogenic DCs, which secrete high levels of IL-10, express ILT4 and HLA-G, and have the specific function to induce Tr1 cells...
  5. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
    ..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
  6. ncbi Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
    Gastroenterology 124:1193-201. 2003
    ..The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite...
  7. doi The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea
    Jung Mook Kang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    J Clin Gastroenterol 43:420-8. 2009
    ..The present study was performed to evaluate whether or not the genetic polymorphisms of IL-6, IL-8, and IL-10 are associated with gastroduodenal disease in the Korean population...
  8. pmc Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Cancer Causes Control 20:1739-51. 2009
    ..Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression...
  9. ncbi Interleukin-10 gene promoter polymorphisms influence the clinical outcome of diffuse large B-cell lymphoma
    Ewa Lech-Maranda
    Equipe d Accueil 3737 Pathologie des Cellules Lymphoïdes, Universite Claude Bernard, Lyon, France
    Blood 103:3529-34. 2004
    ..76, P =.00035) and OS (RR =.78, P =.0015). These results indicate that IL-10 production contributes to the clinical course of DLBCL and that this phenomenon involves a substantial genetic component...
  10. pmc HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells
    Meimei Shan
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS Pathog 3:e169. 2007
    ..Since such mechanisms might suppress immune responses to Env-containing vaccines, demannosylation may be a way to improve the immunogenicity of gp120 or gp140 proteins...
  11. ncbi The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle
    Simone Mocellin
    Department of Oncological and Surgical Sciences, University of Padova, Clinica Chirurgica II, Via Giustiniani, 2, 35128 Padova, Italy
    Cytokine Growth Factor Rev 15:61-76. 2004
    ..g. infectious diseases, autoimmunity, allergy, cancer and transplantation) involving adaptive immunity...
  12. ncbi Ethnic-specific genetic associations with pulmonary tuberculosis
    Julio C Delgado
    Center for Blood Research and Departments of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Infect Dis 186:1463-8. 2002
    ....
  13. ncbi Association of interleukin-1B and interleukin-1RN polymorphisms with gastric cancer in a high-risk population of Costa Rica
    W Alpízar-Alpízar
    Instituto de Investigaciones en Salud INISA, Universidad de Costa Rica, San Pedro, San Jose, Costa Rica
    Clin Exp Med 5:169-76. 2005
    ..This is one of the first studies trying to describe the role played by IL-1B, IL-1RN and IL-10 genetic polymorphisms in gastric cancer in one of the highest risk American countries. Further investigation on American countries is needed...
  14. doi Soybean product intake modifies the association between interleukin-10 genetic polymorphisms and gastric cancer risk
    Kwang Pil Ko
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Nutr 139:1008-12. 2009
    ..38 [1.40-8.13]) relative to the ATA haplotype. Our results suggest that the association between IL-10 genetic polymorphisms and gastric cancer risk was modified by soybean product intake...
  15. doi A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer
    Kent Hart
    Section of Toxicology, Department of Chemical and Biological Work Environment, National Institute of Occupational Health, Oslo, Norway
    Lung Cancer 71:123-9. 2011
    ..19-3.47) whereas individuals with four risk genotypes had 4.62-fold increased risk (OR 4.62, 95% CI, 1.69-12.63). These results highlight the need to investigate the combinatory effects of multiple SNPs in the carcinogenesis of the lung...
  16. doi Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli
    Andrew J Kassianos
    Dendritic Cell Program, Mater Medical Research Institute, South Brisbane, Queensland, Australia
    Eur J Immunol 42:1512-22. 2012
    ..coli-derived Ag and failed to secrete cytokines in response to E. coli. These data demonstrate substantial differences in the nature of the response of human blood DC subsets to E. coli...
  17. ncbi An investigation of polymorphism in the interleukin-10 gene promoter
    D M Turner
    Tissue Typing Laboratory, St Mary s Hospital, Manchester, UK
    Eur J Immunogenet 24:1-8. 1997
    ..We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro...
  18. pmc IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
    Mark A Brockman
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Blood 114:346-56. 2009
    ..These data indicate that multiple cell types contribute to IL-10-mediated immune suppression in the presence of uncontrolled HIV viremia...
  19. pmc Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells
    Megan K Levings
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, Milan 20132, Italy
    J Exp Med 196:1335-46. 2002
    ..Together these data indicate that naturally occurring human CD25(+)CD4(+) T cells are distinct from IL-10-producing Tr1 cells...
  20. ncbi T regulatory-1 cells induce IgG4 production by B cells: role of IL-10
    Judith S Satoguina
    Institute of Medical Parasitology, Friedrich Wilhelm University of Bonn, Bonn, Germany
    J Immunol 174:4718-26. 2005
    ..The correlation between IgG4 and IL-10 (r2 = 0.352) indicates that IL-10 is an important but not the only factor for IgG4 induction...
  21. ncbi Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America
    Ashley Meenagh
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 63:1055-61. 2002
    ..Five populations were investigated, Northern Ireland, South African Zulu, Omani, Singapore Chinese and Mexican Mestizos...
  22. doi The interleukin-10 promoter haplotype ATA is a putative risk factor for aggressive periodontitis
    S Reichert
    University School of Dental Medicine, Department of Operative Dentistry and Periodontology, Martin Luther University Hall Wittenberg, Halle Saale, Germany
    J Periodontal Res 43:40-7. 2008
    ....
  23. pmc Herpes simplex virus remodels T-cell receptor signaling, resulting in p38-dependent selective synthesis of interleukin-10
    Derek D Sloan
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Virol 81:12504-14. 2007
    ..Selective, TCR-stimulated interleukin-10 synthesis may play an important role in HSV pathogenesis...
  24. doi Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study
    Dieter Kube
    Department of Hematology and Oncology and Pharmacology, Medical School of the Georg August University, Gottingen, Germany
    Clin Cancer Res 14:3777-84. 2008
    ..IL-10 was chosen because immune alterations are a major risk factor for NHL, and IL-10 is a cytokine involved in inflammatory processes associated with clinical outcome...
  25. ncbi The recurrence of leprosy reactional episodes could be associated with oral chronic infections and expression of serum IL-1, TNF-alpha, IL-6, IFN-gamma and IL-10
    Ana Carolina F Motta
    Division of Dermatology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Braz Dent J 21:158-64. 2010
    ..05). These results suggest that oral infection could be involved as a maintenance factor in the pathogenesis of leprosy reactional episodes...
  26. doi Lung cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor of DNA binding 3/IL-10 signaling pathway
    Po Lin Kuo
    Institute of Clinical Medicine, Kaohsiung Medical University, 807 Kaohsiung, Taiwan
    J Immunol 186:1521-30. 2011
    ..These results thus suggest that the galectin-1/IL-10 functional axis may be crucial in lung cancer-mediated immune suppression, and that galectin-1 may serve as a target in the development of lung cancer immunotherapy...
  27. pmc Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer
    Rui Wang
    Department of Thoracic Surgery, Shanghai Cancer Hospital, Fudan University, China
    J Exp Clin Cancer Res 30:62. 2011
    ..So it is important to isolate TAM from tumor cells to study the role of IL-10 in the progress of cancer. The aim of our study was to determine whether IL-10 expressed by TAM correlated with clinicopathological factors in NSCLC...
  28. pmc Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein immunodominant epitopes in a highland population from Western Kenya
    Ann M Moormann
    Center for Global Health and Diseases, and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106 7286, USA
    Am J Trop Med Hyg 81:489-95. 2009
    ....
  29. pmc IL-10 production by CD4+ effector T cells: a mechanism for self-regulation
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Mucosal Immunol 3:239-46. 2010
    ..In the following review, we will discuss these findings that support the general concept that production of IL-10 is an important self-regulatory function of CD4(+) T lymphocytes...
  30. ncbi Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus
    J Eskdale
    Immunology Research Group, University of Glasgow Department of Surgery, United Kingdom
    Tissue Antigens 49:635-9. 1997
    ..Although the moderate sample size described in this study requires that the results be interpreted carefully, they provide an interesting and useful framework for future study...
  31. ncbi Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: Risk of preterm birth
    Margaret F Annells
    Department of Microbiology and Infectious Diseases, Women s and Children s Hospital, North Adelaide, South Australia
    Am J Obstet Gynecol 191:2056-67. 2004
    ..The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense...
  32. pmc Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
    Qing Lan
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, MSC 7240, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Blood 107:4101-8. 2006
    ..84; 95% CI = 1.79-8.22; P < .001). Further, the IL10 and IL4 SNP associations remained significant after adjusting for multiple comparisons. These results suggest that SNPs in Th2 cytokine genes may be associated with risk of NHL...
  33. ncbi Impact of aboriginal ethnicity on HCV core-induced IL-10 synthesis: interaction with IL-10 gene polymorphisms
    Koko Bate Aborsangaya
    Section of Hepatology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Hepatology 45:623-30. 2007
    ..As with previous studies, concanavalin A induced IL-10 synthesis from the CA cohort positively associated with defined genetic phenotypes...
  34. ncbi Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Gastroenterol Hepatol 22:1443-9. 2007
    ..The aim of the present study was to clarify the association between the IL-10 polymorphism, one of the representative anti-inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan...
  35. ncbi Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis
    Adnene Salhi
    Institut National de la Santé et de la Recherche Médicale U399, Faculty of Medicine, 17 Boulevard Jean Moulin, Marseille Cedex 05, France
    J Immunol 180:6139-48. 2008
    ..These observations demonstrate an important role for IL-10 in skin lesions in humans infected with L. braziliensis, and identify circulating monocytes and Tregs as principal sources of IL-10 in these patients...
  36. pmc Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II
    Ming Hsi Wang
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Prostate 69:874-85. 2009
    ..Chronic intra-prostatic inflammation and obesity are thought to influence prostate carcinogenesis. Thus, variants in genes in these pathways could be associated with prostate cancer risk...
  37. doi Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression
    Tamara Cacev
    Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka cesta 54, 10000 Zagreb, Croatia
    Carcinogenesis 29:1572-80. 2008
    ..023). Taken together, our results point to possible tumour promoting role of IL-8 and potential protective role of IL-10 in sporadic colon cancer...
  38. doi The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome
    Marcela Claudino
    Department of Biological Sciences, Bauru School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
    J Leukoc Biol 84:1565-73. 2008
    ....
  39. pmc Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    Peter McGuirk
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 195:221-31. 2002
    ..The induction of Tr1 cells after interaction of a pathogen-derived molecule with cells of the innate immune system represents a novel strategy exploited by an infectious pathogen to subvert protective immune responses in vivo...
  40. ncbi IL-10 regulation by HIV-Tat in primary human monocytic cells: involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 MAPK and Sp-1 and CREB-1 transcription factors
    Katrina Gee
    Department of Pathology and Laboratory Medicine, Division of Virology and Molecular Immunology, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, Canada
    J Immunol 178:798-807. 2007
    ..Taken together, our results suggest that extracellular HIV-Tat induced IL-10 transcription in primary human monocytes is regulated by CREB-1 and Sp-1 transcription factors through the activation of calmodulin/CaMK-II-dependent p38 MAPK...
  41. ncbi Impact of serum levels and gene polymorphism of cytokines on chronic hepatitis C infection
    Tzy Yen Chen
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Transl Res 150:116-21. 2007
    ..05). These data suggested the distribution of polymorphism at TNF-alpha G308A may be different between normal subjects and patients with chronic infection of hepatitis C...
  42. pmc Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coinfected population
    Simon Metenou
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:916-24. 2009
    ....
  43. doi Innate transcriptional networks activated in bladder in response to uropathogenic Escherichia coli drive diverse biological pathways and rapid synthesis of IL-10 for defense against bacterial urinary tract infection
    Benjamin L Duell
    School of Medical Sciences, Centre for Medicine and Oral Health, Griffith University Gold Coast Campus, Queensland 4222, Australia
    J Immunol 188:781-92. 2012
    ..Identification of protective roles for other elements in the transcriptome will provide critical new insight into the complex cascade of events that underpin UTI...
  44. doi The Th1/Th2/Th17 cytokine profile of HIV-infected individuals: a multivariate cytokinomics approach
    Aurelia Williams
    Department of Biochemistry, University of Pretoria, Pretoria 0002, South Africa
    Cytokine 61:521-6. 2013
    ..This possibility was supported by other clinical indicators. Taken together, the measured cytokines (IL-6, 10 and 17) have potential prognostic value...
  45. doi Circulatory hepcidin is associated with the anti-inflammatory response but not with iron or anemic status in childhood malaria
    Florence Burté
    Division of Parasitology, Medical Research Council National Institute for Medical Research, London, UK
    Blood 121:3016-22. 2013
    ..We propose a role for hepcidin in anti-inflammatory processes in childhood malaria...
  46. ncbi Genetic variants of TNF-[FC12]a, IL-1beta, IL-4 receptor [FC12]a-chain, IL-6 and IL-10 genes are not risk factors for sepsis in low-birth-weight infants
    Andras Treszl
    Research Laboratory of Pediatrics and Nephrology, Semmelweis University, Budapest, Hungary
    Biol Neonate 83:241-5. 2003
    ..We concluded that these genetic polymorphisms do not influence the risk and course of sepsis in VLBW neonates...
  47. ncbi Genomic polymorphic profiles in an Irish population with meningococcaemia: is it possible to predict severity and outcome of disease?
    J Balding
    Department of Genetics, Trinity College, Dublin, Ireland
    Genes Immun 4:533-40. 2003
    ..We conclude that genetic variability in the IL-6, IL-10, and IL-1RN genes is associated with a poor outcome in meningococcal disease...
  48. ncbi Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefighters
    Jefferey L Burgess
    University of Arizona, Tucson, Arizona, USA
    J Occup Environ Med 46:1013-22. 2004
    ..Evaluation of gene polymorphisms regulating lung inflammation may help to explain some of the variation in rate of decline in lung function in firefighters...
  49. ncbi Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma association
    Alexandra Nieters
    Department of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer 103:740-8. 2005
    ..However, only a minority of HBV carriers eventually develop hepatocellular carcinoma. The authors hypothesized that cytokine genotypes may be important codeterminants of the risk of HBV-related hepatocellular carcinoma...
  50. pmc TNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease
    E V Fowler
    J Med Genet 42:523-8. 2005
    ..Certain single nucleotide polymorphisms (SNPs) within the promoter region of the IL10 (-1082G/A, -592C/A) and TNFalpha (-308G/A, -857C/T) genes have been associated with altered levels of circulating IL10 and TNFalpha...
  51. ncbi The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland
    Mairi Macarthur
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005
    ..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required...
  52. doi Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients
    Andrzej Szkaradkiewicz
    Department of Medical Microbiology, University of Medical Sciences, Wieniawskiego 3, 61 712 Poznań, Poland
    Arch Immunol Ther Exp (Warsz) 57:291-4. 2009
    ....
  53. pmc Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population
    Maris Kuningas
    Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 4:e7795. 2009
    ..Pro-inflammatory host responses that are deleterious later in life may originate from evolutionary selection for genetic variation mediating resistance to infectious diseases under adverse environmental conditions...
  54. ncbi Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians
    Dejan Trajkov
    Institute of Immunobiology and Human Genetics, Faculty of Medicine, University St Kiril and Metodij, Skopje, Republic of Macedonia
    Indian J Tuberc 56:117-31. 2009
    ..To examine the possible role of 22 cytokine gene polymorphisms in host susceptibility to or protection against tuberculosis (TB) in Macedonians...
  55. pmc Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study
    Vibeke Andersen
    Medical Department, SHS Aabenraa, Aabenraa, Denmark
    BMC Cancer 12:183. 2012
    ..Diet and lifestyle may be linked to cancer through inflammation. Interleukin-10 (IL-10) is an anti-inflammatory cytokine. We wanted to test if dietary factors and IL10 polymorphisms interact in relation to colorectal carcinogenesis...
  56. doi Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population
    Hyun Kyung Park
    Departments of Emergency Medicine, School of Medicine, Kyung Hee University, Seoul, 130 701, Republic of Korea
    Mol Biol Rep 40:1785-90. 2013
    The pathogenesis of stroke is associated with the immune and inflammatory responses. Cytokines, such as interleukin 10 (IL10), play an important role in the process of inflammation...
  57. pmc Interaction among variant vascular endothelial growth factor (VEGF) and its receptor in relation to prostate cancer risk
    Tiva T VanCleave
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, USA
    Prostate 70:341-52. 2010
    ..This study evaluates the interplay among three highly variant genes (i.e., IL-10, TGFbetaR-1, VEGF), their receptors and their influence on PCa within a case-control study consisting of an under-served population...
  58. ncbi HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones
    C Speth
    Institute for Hygiene, University of Innsbruck and Ludwig Boltzmann Institute for AIDS Research, Austria
    AIDS 14:629-36. 2000
    ..To analyse the effect of HIV-1 transmembrane protein gp41 on cytokine production and chemokine receptor expression in blood and brain...
  59. ncbi The role of interleukin-10 promoter polymorphisms in the clinical expression of primary Sjögren's syndrome
    J Font
    Systemic Autoimmune Diseases Unit, Hospital Clinic, School of Medicine, University of Barcelona, Barcelona, Spain
    Rheumatology (Oxford) 41:1025-30. 2002
    ..To analyse the role of polymorphisms of the interleukin-10 promoter region in the epidemiologic, clinical and immunologic characteristics of patients with primary Sjögren's syndrome (SS)...
  60. ncbi Interleukin-10 genotypes associate with the risk of gastric carcinoma in Taiwanese Chinese
    Ming Shiang Wu
    Department of Internal Medicine, National Taiwan University Hospital Taipei, Taiwan
    Int J Cancer 104:617-23. 2003
    ..54, 95% CI 1.24-5.61) are independent risks for GC. Independent effects of IL-10 genotype, H. pylori infection and cigarette smoking indicate that carcinogenesis of GC is influenced by a variety of host and environmental factors...
  61. ncbi Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance
    T K Oleksyk
    Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Genes Immun 6:347-57. 2005
    ..Some previous reports have implicated interleukin 10 (IL10) polymorphisms with successful anti-HCV therapy and natural viral clearance...
  62. pmc Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome
    M N Gong
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mount Sinai School of Medicine, New York, NY, and Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston 02115, USA
    Eur Respir J 27:674-81. 2006
    ..Among those with acute respiratory distress syndrome, the -1082GG genotype is associated with lower mortality and organ failure. Further studies are needed to confirm these findings...
  63. doi Interleukin-10 -1082 promoter polymorphism associated with gastric cancer among Asians
    Yong Zhou
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
    Eur J Cancer 44:2648-54. 2008
    ..This meta-analysis suggests that the IL-10 -1082 promoter polymorphism may be associated with gastric cancer among Asians, and that differences in genotype distribution may be associated with the location of gastric cancer...
  64. doi IL-10 suppresses CD2-mediated T cell activation via SHP-1
    Alison Taylor
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Mol Immunol 46:622-9. 2009
    ..In conclusion, SHP-1-mediated inhibition of CD2 signaling represents a novel mechanism for direct T cell suppression by IL-10...
  65. pmc Role of bacterial and genetic factors in gastric cancer in Costa Rica
    Sergio A Con
    Centro Digestivo Doctores Con Mediplaza, Pavas 245 1200, San Jose, Costa Rica
    World J Gastroenterol 15:211-8. 2009
    ..To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR)...
  66. ncbi Involvement of T(H)1/T(H)2 cytokines in the pathogenesis of autoimmune skin disease-Pemphigus vulgaris
    Abhigyan Satyam
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Immunol Invest 38:498-509. 2009
    ..The decreased levels of IL-2 and IFN-gamma might demonstrate the inhibitory effects by IL-4 and IL-10, which suppress the expansion of T(H)1 population...
  67. pmc The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
    Vibeke Andersen
    Medical Department, Viborg Regional Hospital, DK 8800 Viborg, Denmark
    BMC Med Genet 11:82. 2010
    ..anti-oxidant enzyme, whereas the pro-inflammatory interleukin 1 beta (IL-1 beta/IL1B) and anti-inflammatory interleukin 10 (IL-10/IL10) are key modulators for the initiation and maintenance of inflammation...
  68. doi Lack of association between IL-1β, TNF-α, and IL-10 gene polymorphisms and sporadic Parkinson's disease in an Italian cohort
    E Pascale
    Dipartimento di Scienze e Biotecnologie Medico Chirurgiche, Sapienza Universita di Roma, Italy
    Acta Neurol Scand 124:176-81. 2011
    ..Different functional promoter polymorphisms within genes coding pro- or anti-inflammatory cytokines involved in the immune reactions in the brain might influence the risk of developing PD or the age of disease onset...
  69. ncbi Association of -592 region of IL-10 polymorphisms with asthma in south-eastern Iranian patients
    Elham Hakimizadeh
    Physiology and Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
    Clin Lab 58:267-71. 2012
    ..The aim of this study was to investigate the association between this disease and polymorphisms in the -592 region of the IL-10 gene...
  70. pmc Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
    ....
  71. ncbi Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site
    K Josephson
    Center for Macromolecular Crystallography, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 15:35-46. 2001
    b>Interleukin 10 (IL-10) is a dimeric cytokine that plays a central role in suppressing inflammatory responses. These activities are dependent on the interaction of IL-10 with its high-affinity receptor (IL-10R1)...
  72. ncbi An association between polymorphisms of the interleukin-10 gene promoter and schizophrenia in the Chinese population
    Lan Yu
    Institute of Nutrition Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, PR China
    Schizophr Res 71:179-83. 2004
    ..The observed haplotype distributions revealed a significant association with schizophrenia (P=0.0008). These data suggest that the IL-10 gene may confer susceptibility to the development of schizophrenia in the Chinese population...
  73. ncbi Induction of lytic cycle replication of Kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1: involvement of IL-10 and IL-4
    Di Qin
    Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, and Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, China
    Cell Microbiol 10:713-28. 2008
    ..Our data present the first direct evidence that HSV-1 can activate KSHV lytic replication and suggest a role of HSV-1 in KSHV pathogenesis...
  74. pmc Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects
    Kai Wang
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:2059-67. 2010
    ....
  75. doi Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    Yuri P Rubtsov
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 28:546-58. 2008
    ..Furthermore, these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting...
  76. pmc Polymorphisms of some cytokines and chronic hepatitis B and C virus infection
    Qiu Ju Gao
    Department of Epidemiology, Public Health College, Hebei Medical University, Hebei Province, China
    World J Gastroenterol 15:5610-9. 2009
    ..To study the relationship between the polymorphisms in some cytokines and the outcome of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection...
  77. doi Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci
    Nobuhisa Mizuki
    Department of Ophthalmology and Visual Science, Yokohama City University, Yokohama, Kanagawa, Japan
    Nat Genet 42:703-6. 2010
    ..9 x 10(-11), odds ratio = 1.35; rs1800871 in IL10, P = 1.0 x 10(-14), odds ratio = 1.45)...
  78. pmc Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis
    David E Kaplan
    Research Section, Philadelphia VA Medical Center, Research A216, 3900 Woodland Avenue, Philadelphia, PA 19104, USA
    J Hepatol 48:903-13. 2008
    ..In this study, we examined the role of HCV-specific T-cell IL-10 response in patients with acute and chronic HCV infection...
  79. ncbi Interleukin-10 and tumor necrosis factor gene polymorphisms and risk of coronary artery disease and myocardial infarction
    W Koch
    Deutsches Herzzentrum München and 1 Medizinische Klinik rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Atherosclerosis 159:137-44. 2001
    ....
  80. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
    ..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
  81. ncbi Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancer
    Dominique S Michaud
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Res 66:4525-30. 2006
    ..At least seven common polymorphisms in genes of inflammatory cytokines IL-1B, IL-6, IL-8, and IL-10 do not seem to play a role in the risk of prostate cancer...
  82. pmc Placental IL-10 dysregulation and association with bronchopulmonary dysplasia risk
    Elisabeth C McGowan
    Department of Pediatrics, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island 02915, USA
    Pediatr Res 66:455-60. 2009
    ..01-0.70, p = 0.02). These results suggest that a placental balance between inflammatory and anti-inflammatory cytokines is crucial to normal lung organogenesis. Importantly, IL-10 seems to be protective against the development of BPD...
  83. doi IL-10 blocks phagosome maturation in mycobacterium tuberculosis-infected human macrophages
    Seónadh O'Leary
    Respiratory Medicine, St James s Hospital, CREST, Dublin 8, Ireland
    Am J Respir Cell Mol Biol 45:172-80. 2011
    ..IL-10 is a feature of human tuberculous granuloma, and these new findings support the hypothesis that this cytokine can promote pathogen persistence by contributing to Mtb-phagosome maturation arrest in human macrophages...
  84. pmc Effects of interleukin-10 polymorphisms, Helicobacter pylori infection, and smoking on the risk of noncardia gastric cancer
    Jeongseon Kim
    Cancer Epidemiology Branch, National Cancer Center, Goyang, Korea
    PLoS ONE 7:e29643. 2012
    ..Therefore, we investigated the associations between IL10 polymorphisms, Helicobacter pylori (H. pylori) infection, and smoking in noncardia gastric carcinogenesis in Koreans...
  85. ncbi Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma
    A Zdanov
    Macromolecular Structure Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Structure 3:591-601. 1995
    ..An atomic model is necessary to interpret biological activity of IL-10 and to design mutants with agonistic or antagonistic properties...
  86. pmc +1 Frameshifting as a novel mechanism to generate a cryptic cytotoxic T lymphocyte epitope derived from human interleukin 10
    Xavier Saulquin
    INSERM U463, Institut de Biologie, Nantes Cedex 01, France
    J Exp Med 195:353-8. 2002
    ..These observations illustrate the variety of mechanisms leading to generation of cryptic epitopes and suggest that frameshifting in normal cellular genes may be more common than expected...
  87. pmc Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: expression profile of pathogenetically relevant genes
    Alessia A Bettaccini
    Dipartimento di Scienze Cliniche e Biologiche, Universita dell Insubria, Varese, Italy
    BMC Microbiol 5:20. 2005
    ..The activity of two-exon (aa 1-101) and synthetic (aa 1-86) Tat was studied on mammary and amniotic epithelial cells cultured under low serum conditions...
  88. ncbi The role of interleukin 10 promoter polymorphisms in the susceptibility of distal interphalangeal osteoarthritis
    Naghmeh Riyazi
    Department of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, The Netherlands
    J Rheumatol 32:1571-5. 2005
    ..We investigated the association of 7 novel SNP located downstream of the IL-10 transcription start site: -2849,-2763, -1330, -1082, -819, and -592, constituting the 4 ancient haplotypes, with distal interphalangeal (DIP) OA...
  89. doi Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations
    Mahmoud R Hussein
    Pathology Department, Faculty of Medicine, Assuit University and Assir Central Hospitals, Assuit, Egypt
    Pathol Oncol Res 14:321-8. 2008
    ..To conclude, the development of rheumatoid arthritis and osteoarthritis is associated with alteration of the levels of some cytokines. The assessment of these immunologic changes may have potential prognostic roles...
  90. doi HIV-1 Tat protein induces IL-10 production by an alternative TNF-alpha-independent pathway in monocytes: role of PKC-delta and p38 MAP kinase
    Kaoutar Leghmari
    Laboratoire d Immuno Virologie, EA 3038, Université Paul Sabatier 118, route de Narbonne 4R3, 31062 Toulouse, Cedex, France
    Cell Immunol 253:45-53. 2008
    ..In consequence, HIV-1 may escape immune surveillance and thus promote the establishment of an immunosuppressive state...
  91. pmc Interleukin-10 promoter polymorphisms influence HIV-1 susceptibility and primary HIV-1 pathogenesis
    Dshanta D Naicker
    Hasso Plattner Research Laboratory, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa
    J Infect Dis 200:448-52. 2009
    ..Thus, IL-10 may influence HIV-1 susceptibility and pathogenesis, but effects on the latter may differ according to the infection phase...
  92. pmc Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
    F Rousset
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    Proc Natl Acad Sci U S A 89:1890-3. 1992
    b>Interleukin 10 (IL-10), originally identified as a TH2 helper T-cell product able to inhibit cytokine production by TH1 cells, is highly homologous to BCRF1 (viral IL-10), an open reading frame in the Epstein-Barr virus genome...
  93. pmc Interleukin 10 secretion in relation to human IL-10 locus haplotypes
    J Eskdale
    University of Glasgow Department of Surgery, Queen Elizabeth Building, Glasgow Royal Infirmary Glasgow G31 2ER, Scotland
    Proc Natl Acad Sci U S A 95:9465-70. 1998
    ..of human blood cultures with bacterial lipopolysaccharide (LPS) shows large inter-individual variation in interleukin 10 (IL-10) secretion, which has been shown to have a genetic component of over 70%...
  94. ncbi Interleukin 10 haplotype associated with increased risk of hepatocellular carcinoma
    Hyoung Doo Shin
    Department of Genetic Epidemiology, SNP Genetics, Inc, 11th Floor, MaeHun B D, 13 Chongro 4 Ga, Chongro Gu, Seoul 110 834, Korea
    Hum Mol Genet 12:901-6. 2003
    b>Interleukin 10 (IL10) is a powerful Th-2 cell cytokine produced by lymphoid cells that exerts its functions by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of inflammatory cytokines (IL1, TNFA, TGFB, IL6, ..
  95. ncbi Interleukin 10-2849AA genotype protects against pre-eclampsia
    C J M de Groot
    1Department of Obstetrics and Gynecology, Erasmus Medical Center Rotterdam, The Netherlands
    Genes Immun 5:313-4. 2004
    Recently, it has been described that human fertility is associated with the interleukin 10 (IL10) -2849 AA genotype. Pre-eclampsia is the most common pregnancy-specific complication...
  96. ncbi IL-6 and IL-10 promoter gene polymorphisms of patients and donors of allogeneic sibling hematopoietic stem cell transplants associate with the risk of acute graft-versus-host disease
    Lidia Karabon
    Lower Silesian Center for Cellular Transplantation and National Polish Bone Marrow Donor Registry, Wroclaw, Poland
    Hum Immunol 66:700-10. 2005
    ..These analyses confirmed the independent contribution of recipient IL-10 GCC/GCC (odds ratio = 0.085, p = 0.046) and donor IL-6 GG (odds ratio = 3.934, p = 0.034) genotypes to the risk of aGVHD...
  97. ncbi Association of interleukin-6, interleukin-12, and interleukin-10 gene polymorphisms with essential hypertension in Tatars from Russia
    Y R Timasheva
    Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Science, Ufa, Russia
    Biochem Genet 46:64-74. 2008
    ..Our results suggest a role for cytokines in cardiovascular disease development in the Tatar ethnic group, but further investigation is needed...
  98. doi Interactions of cytokine gene polymorphisms in prostate cancer risk
    Jovanny Zabaleta
    Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar Street, CSRB 455, New Orleans, LA 70112, USA
    Carcinogenesis 29:573-8. 2008
    ..92, 95% CI = 1.13-7.55) and the genotype combination of TNF-238GG plus IL10-592AA (OR = 2.14, 95% CI = 1.05-4.38). Our results highlight the importance of cytokine SNPs and their interactions in CaP risk...
  99. pmc ATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: a case control study
    Berta Almoguera
    Genetics Department, CAIBER Unit, IIS Fundación Jiménez Díaz, Madrid, Spain
    BMC Med Genet 12:81. 2011
    ....
  100. doi Interleukin-10-1082A/G polymorphism and inflammatory bowel disease susceptibility: a meta-analysis based on 17,585 subjects
    Hang Zhu
    Maternal and Child Hygiene Department, School of Public Health and Management, Chongqing Medical University, China
    Cytokine 61:146-53. 2013
    ..Due to several limitations in the present study, well-designed epidemiological studies with large sample size among different ethnicities should be performed in the future...
  101. ncbi Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor
    D Franchimont
    Department of Gastroenterology CHU, University of Liege, Belgium
    J Clin Endocrinol Metab 84:2834-9. 1999
    ..This study suggests that the pattern of pro-/antiinflammatory cytokine secretion may alter the response of patients to glucocorticoid therapy...

Research Grants63

  1. Proinflammatory Biomarkers and Post-Breast CancerLymphedema
    Mei Rosemary Fu; Fiscal Year: 2012
    ..Findings of the project are fundamental in developing and testing more intense and personalized interventions to prevent and treat LE among the breast cancer survivors. ..
  2. Disparities in Breast Cancer: Development and Survival in Hispanic and NHW Women
    Martha L Slattery; Fiscal Year: 2013
    ..These genetic factors will be evaluated with survival to determine their contribution to survival differences observed for Hispanic and NHW women. ..
  3. Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer
    Martha L Slattery; Fiscal Year: 2012
    ..Identification of polymorphisms or haplotypes that are relevant to colorectal cancer will advance our understanding of etiology, may lead to specific health recommendations, and can identify targets for drug therapy. ..
  4. Pathway analysis of tuberculosis pathogenesis
    CATHERINE MARIE STEIN; Fiscal Year: 2013
    ..Findings of this project will expand knowledge of the joint genetic, epidemiologic, and immunologic influences on Mtb infection and TB disease, which will facilitate the development of improved vaccines and therapeutics. ..
  5. Jonathan Savitz; Fiscal Year: 2016
    ....
  6. Daniela Salvemini; Fiscal Year: 2016
    ..Given the breadth of disorders impacted by A3AR agonists understanding their mechanism-based effects has far-reaching basic science &clinical implications. ..
  7. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..Cytokine genes are expressed at different levels in older compared to younger women;therefore, we will also evaluate their contribution to breast cancer risk by levels of common exposures such as obesity and HRT use. ..
  8. Aaron W Michels; Fiscal Year: 2016
    ....
  9. Thalachallour Mohanakumar; Fiscal Year: 2015
    ....
  10. Alexander Miethke; Fiscal Year: 2016
    ....
  11. Interleukin-10 and Regulation of Skeletal Muscle Insulin Action
    Jason K Kim; Fiscal Year: 2012
    ..Our findings will provide important insights into the role of obesity and inflammation in insulin resistance and further identify novel therapeutic targets in the treatment of type 2 diabetes. ..
  12. B-Cell Tolerance Mechanisms in Human SLE
    JENNIFER HOWITT ANOLIK; Fiscal Year: 2013
    ..The knowledge gained from the present studies will help us understand the multiple functions of B cells in autoimmunity and develop better strategies for the treatment of lupus and other autoimmune diseases. ..
  13. Alessandro Sette; Fiscal Year: 2016
    ..abstract_text> ..
  14. Jaroslaw Aronowski; Fiscal Year: 2016
    ....
  15. Analysis of the STAT3 Pathway In Tumor Tolerance and Immune Evasion
    Drew M Pardoll; Fiscal Year: 2010
    ....
  16. Susan E Erdman; Fiscal Year: 2014
    ..We propose to build upon our recent scientific breakthroughs and test strategies in mice that will stimulate potent and highly beneficial Treg to prevent cancer and impart healthful longevity in humans. ..
  17. BROC TAYLOR MCCUNE; Fiscal Year: 2015
    ....
  18. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
    ..If factors associated with animal or endotoxin contact are related to asthma risk, such factors would likely lend themselves to public health interventions. ..
  19. B cell function and phenotype as predictors of therapeutic response to rituximab
    David J Rawlings; Fiscal Year: 2010
    ..In this application, we will test the idea that alterations in B cell signaling: a) represent a fixed deficit in T1D subjects evident via natural history analyses;and b) may predict the response to B cell depletion therapy. ..
  20. Carl F Nathan; Fiscal Year: 2014
    ..We will explore Celgene's extensive library of kinase inhibitors to identify potent, relatively selective inhibitors of PKR and characterize them as SAMs in vitro and in Mtb-infected mice. ..
  21. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2004
    ....
  22. William M Geisler; Fiscal Year: 2016
    ..Study findings should provide systemic and mucosal immune correlates of protection needed for CT vaccine studies. ..
  23. Anjana Rao; Fiscal Year: 2014
    ..In this proposal we plan to investigate the role of TET proteins in T cells, a major class of cells in the immune system that protect the organism from attack by bacteria, viruses and other pathogens including cancer cells. ..
  24. Claude A Piantadosi; Fiscal Year: 2016
    ..Positive predictive studies in human ALI/ARDS would have a high impact on our understanding of the resolution of sepsis and MODS. ..
  25. Howard L Weiner; Fiscal Year: 2015
    ..We will investigate mechanisms to induce regulatory T cells by oral tolerance, which takes advantage of natural protective mechanisms that exist in the gut. ..
  26. Jonathan Cheetham; Fiscal Year: 2015
    ..This team will support me in this proposal and through my transition to independence. ..
  27. Christian Jobin; Fiscal Year: 2016
    ..In addition, the basic knowledge gained from metagenomic studies is expected to move the general field of CRC research forward. ..
  28. James P Nataro; Fiscal Year: 2014
    ..In this project, we will further characterize the mechanisms of EAEC- induced diarrhea with an eye toward development of effective preventive measures. ..
  29. ELLEN ELIZABETH SPARGER; Fiscal Year: 2015
    ..Importantly, these studies will examine and develop a novel vaccine approach that is not previously tested in the SIVmac vaccine model, and carries the potential to significantly impact HIV vaccine design. ..
  30. Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin
    Xiaojing Ma; Fiscal Year: 2011
    ..abstract_text> ..
  31. SIMON PATRICK HOGAN; Fiscal Year: 2015
    ....
  32. Helminthic Protection from IBD
    JOEL VINCENT WEINSTOCK; Fiscal Year: 2013
    ..Results from this study could help improve the treatment of patients with IBD and other immunological disease. ..
  33. Francisco J Quintana; Fiscal Year: 2015
    ..We will investigate how a protein called Aryl Hydrocarbon Receptor controls the immune system and how affecting it ameliorates an animal model of multiple sclerosis. ..
  34. Diagnosis and Pathobiology of Emerging Enterohepatic Helicobacter spp. in Mice
    James G Fox; Fiscal Year: 2011
    ..The proposal addresses molecular targets for diagnosis and characterization of EHS and will take advantage of sequenced EHS that colonize mice to probe virulence determinants shared among these EHS isolated from both mice and humans. ..
  35. Casey T Weaver; Fiscal Year: 2016
    ..Using this model, we will be able to define the function of Gfi1-binding CREs in the human IL10 locus by examining the effects of mutation of these elements on IL10 gene remodeling, expression and protection in the EAE model. ..
  36. Leona D Samson; Fiscal Year: 2014
    ..Understanding how DNA repair contributes to carcinogenesis will provide insights into the mechanism by which chronic inflammation increases the chance of cancer as well as identify possible approaches to decrease cancer risk. ..
  37. James G Fox; Fiscal Year: 2014
    ..To accomplish these aims we have assembled a team of scientists who have successfully collaborated together for the last decade to study the etiopathogenesis of H. hepaticus gastrointestinal disease in mice. ..
  38. A Comparative Genomics and Transgenic Approach to Regulation of IL-10 Expression.
    Jay H Bream; Fiscal Year: 2013
    ..Together, these studies will clarify how cell- and allele-specific regulation of hIL-10 production contributes to human inflammatory diseases. ..
  39. Meghan E Turnis; Fiscal Year: 2014
    ..Research on these Aims should yield exciting knowledge that will advance the field and hopefully prove to be therapeutically beneficial. ..
  40. Helminthic Protection from IBD
    Joel Weinstock; Fiscal Year: 2009
    ..This investigation may provide fresh insight into the pathogenesis of IBD and lead to better treatment. ..
  41. In vivo function and tolerance to Factor VIII variants
    BRENDAN HL LEE; Fiscal Year: 2011
    ..abstract_text> ..
  42. Mechanism of immune regulation by CD11b+ myeloid cells in the intestine
    Masako Murai; Fiscal Year: 2013
    ..To prevent chronic inflammation, various cell populations keep the mucosal immune response in check. Interleukin 10 (IL-10) is known as a cytokine with anti-inflammatory properties...
  43. Cellular Immunity and the Outcome of Hepatitis C Virus Infection
    Kyong Mi Chang; Fiscal Year: 2010
    ..The proposed studies will provide novel insights to underlying immunological mechanisms of T cell dysfunction and HCV persistence with potential therapeutic application. ..
  44. DARIO AA VIGNALI; Fiscal Year: 2015
    ..Furthermore, this will also lead to the development of improved vaccination strategies for chronic infections and new therapies for cancer. ..
  45. Stephania Cormier; Fiscal Year: 2016
    ....
  46. Genetic adaptation in Campylobacter: mechanisms and impacts on human health
    John E Linz; Fiscal Year: 2010
    ....
  47. Lineage Specific Effects of IL10 In Autoimmunity
    Terrence L Geiger; Fiscal Year: 2013
    ..abstract_text> ..
  48. GPR30-induced Tregs: a therapeutic approach to reversing colitis
    Ryan Brunsing; Fiscal Year: 2012
    ..In addition, my findings will determine the potential of GPR30-directed small molecules to reverse IBD-like intestinal inflammation. ..
  49. Carson E Moseley; Fiscal Year: 2016
    ..While this project will investigate the regulation of Il10 by the use of mous models, our molecular studies will be guided by data from GWAS of humans with IBD. Thus, it should also shed light on IL10 regulation in human disease. ..
  50. Antibody induced T cell-mediated neonatal autoimmunity.
    Kenneth S K Tung; Fiscal Year: 2012
    ..abstract_text> ..
  51. JOEL VINCENT WEINSTOCK; Fiscal Year: 2014
    ..Our long-term objective is to develop new drugs to treat IBD that can act independent of helminths to trigger these regulatory pathways. ..
  52. Mouse Strain dependent innate resistance to intestinal amebiasis
    Eric Houpt; Fiscal Year: 2009
    ....
  53. GASTRIC PRENEOPLASIA IN H FELIS INFECTED IL10 MICE
    Daniel Berg; Fiscal Year: 2002
    ..the development of preneoplastic gastric epithelium, using a novel animal model, Helicobacter felis-infected interleukin 10-deficient mice (IL10-/-)...
  54. REGULATION OF AUTOREACTIVE T CELLS IN IL10 KNOCKOUT MICE
    Peter Ernst; Fiscal Year: 1999
    ..Clarifying the role of these cytokines controlling auto-reactive T cells will define the pathogenesis of colitis and identify therapeutic strategies that can be applied to these intestinal diseases. ..
  55. Mark R Walter; Fiscal Year: 2016
    ..Aim 2) Comparison of RhCMV reinfection in RhCMV-immune monkeys that differ in their NAb titers to rhcmvIL10. Aim 3) Characterization of rhcmvIL-10-induced alterations to host immunity. ..
  56. Substance P & the Regulation of Intestinal Inflammation
    Joel Weinstock; Fiscal Year: 2009
    ..Strategies aimed at modulating NK-1 R function in the gut could prove therapeutically beneficial for IBD. ..
  57. CHARACTERIZATION/MODULATION OF CYTOKINE RESPONSES IN FIV
    Gregg Dean; Fiscal Year: 2001
    ..Understanding the role of the cytokines in the pathogenesis, therapy, and vaccination in FIV infection will have direct implications for HIV infection. ..
  58. Immunogenetics of Cervical Cancer A Family-Based Design
    Stephen Schwartz; Fiscal Year: 2005
    ..The proposed study will contribute to our understanding of the role of immune response and genetics in invasive cervical cancer etiology, both of which may have a direct impact on vaccine development. ..
  59. FIV/HIV IMMUNOPATHOGENESIS--A CASE FOR THE CD8+ CELL
    Wayne Tompkins; Fiscal Year: 2002
    ..g. IL10) is selectively recruited into inflammatory sites and suppresses immune responses to secondary pathogens. ..
  60. Mechanisms of NSAID-induced inflammatory Bowel Disease
    Daniel Berg; Fiscal Year: 2007
    ..abstract_text> ..
  61. MECHANISMS OF ALLOGRAFT TOLERANCE
    Charles Orosz; Fiscal Year: 2002
    ..Finally, we will evaluate the effects of concurrent infection with murine influenza virus on he survival of the graft and recipient in mice that are being educated with BSA for allograft acceptance. ..
  62. Pain control via spinal interleukin-10 gene therapy
    Linda Watkins; Fiscal Year: 2003
    ..This approach to pain control represents a dramatic departure from all other available therapies. ..
  63. IL10 and IGF1 Receptor Axis in Prostate Cancer
    Mark Stearns; Fiscal Year: 2005
    ..Development of therapeutic agents, which target the IL-10R or IGF-R1 axis should be beneficial in the treatment of the disease. ..