IKZF1

Summary

Gene Symbol: IKZF1
Description: IKAROS family zinc finger 1
Alias: CVID13, Hs.54452, IK1, IKAROS, LYF1, LyF-1, PPP1R92, PRO0758, ZNFN1A1, DNA-binding protein Ikaros, CLL-associated antigen KW-6, ikaros family zinc finger protein 1, lymphoid transcription factor LyF-1, protein phosphatase 1, regulatory subunit 92, zinc finger protein, subfamily 1A, 1 (Ikaros)
Species: human

Top Publications

  1. doi Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance
    Ilaria Iacobucci
    Department of Hematology Oncology, L and A Seragnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Blood 112:3847-55. 2008
  2. ncbi Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment
    K Georgopoulos
    Cutaneous Biology Research Center, Harvard Medical School, Massachusetts General Hospital, Charlestown 02114
    Science 258:808-12. 1992
  3. ncbi Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
    J Kim
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Immunity 10:345-55. 1999
  4. pmc Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes
    J Koipally
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 18:3090-100. 1999
  5. ncbi Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia
    L Sun
    Parker Hughes Cancer Center and Children s Cancer Group ALL Biology Reference Laboratory, Hughes Institute, St Paul, MN 55113, USA
    J Clin Oncol 17:3753-66. 1999
  6. ncbi Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
    J Koipally
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 275:19594-602. 2000
  7. pmc An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells
    D W O'Neill
    Departments of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell Biol 20:7572-82. 2000
  8. ncbi Ikaros isoform x is selectively expressed in myeloid differentiation
    Kimberly J Payne
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Immunol 170:3091-8. 2003
  9. ncbi STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells
    Wai Ho Yap
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    FEBS Lett 579:4470-8. 2005
  10. ncbi The role of Ikaros in human erythroid differentiation
    Marilyne Dijon
    Centre de Thérapie Cellulaire et Génique, Institut Paoli Calmettes, Marseille, France
    Blood 111:1138-46. 2008

Research Grants

  1. Mark C Horowitz; Fiscal Year: 2014
  2. Mechanisms underlying loss of neural stem cell competence.
    Minoree Kohwi; Fiscal Year: 2013
  3. Stephen T Smale; Fiscal Year: 2014
  4. The role of E47 in uncommitted hematopoietic progenitors
    Lisa Borghesi; Fiscal Year: 2013
  5. Drew M Pardoll; Fiscal Year: 2014
  6. GENOMIC ANALYSIS OF ADOLESCENT AND YOUNG ADULT ACUTE LYMPHOBLASTIC LEUKEMIA
    Cheryl L Willman; Fiscal Year: 2010
  7. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Q Doe; Fiscal Year: 2012
  8. The role of Ikaros in regulation of Notch target gene expression
    SUSAN M WINANDY; Fiscal Year: 2010
  9. Assembly and Trafficking of IK1 and SK3 in Endothelia
    Daniel C Devor; Fiscal Year: 2012
  10. The Role of Ikaros in Regulatory T Cells that Protect Against Allergic Asthma
    SARAH UMETSU; Fiscal Year: 2011

Detail Information

Publications208 found, 100 shown here

  1. doi Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance
    Ilaria Iacobucci
    Department of Hematology Oncology, L and A Seragnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Blood 112:3847-55. 2008
    b>Ikaros plays an important role in the control of differentiation and proliferation of all lymphoid lineages...
  2. ncbi Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment
    K Georgopoulos
    Cutaneous Biology Research Center, Harvard Medical School, Massachusetts General Hospital, Charlestown 02114
    Science 258:808-12. 1992
    ..control differentiation into the T cell lineage, a complementary DNA was isolated encoding a zinc finger protein (Ikaros) related to the Drosophila gap protein Hunchback...
  3. ncbi Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
    J Kim
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Immunity 10:345-55. 1999
    The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system...
  4. pmc Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes
    J Koipally
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 18:3090-100. 1999
    Here we show that the lymphoid lineage-determining factors Ikaros and Aiolos can function as strong transcriptional repressors...
  5. ncbi Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia
    L Sun
    Parker Hughes Cancer Center and Children s Cancer Group ALL Biology Reference Laboratory, Hughes Institute, St Paul, MN 55113, USA
    J Clin Oncol 17:3753-66. 1999
    We sought to determine if molecular abnormalities involving the Ikaros gene could contribute to the development of acute lymphoblastic leukemia (ALL) in children.
  6. ncbi Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
    J Koipally
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 275:19594-602. 2000
    We have previously shown that Ikaros can repress transcription through the recruitment of histone deacetylase complexes...
  7. pmc An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells
    D W O'Neill
    Departments of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell Biol 20:7572-82. 2000
    ..In addition, we show that the hematopoietic cell-restricted zinc finger protein Ikaros copurifies with PYR complex DNA-binding activity and that antibodies to Ikaros also supershift the complex...
  8. ncbi Ikaros isoform x is selectively expressed in myeloid differentiation
    Kimberly J Payne
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Immunol 170:3091-8. 2003
    The Ikaros gene is alternately spliced to generate multiple DNA-binding and nonbinding isoforms that have been implicated as regulators of hematopoiesis, particularly in the lymphoid lineages...
  9. ncbi STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells
    Wai Ho Yap
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    FEBS Lett 579:4470-8. 2005
    ..of the 5' flanking regions of human, mouse and pufferfish (Fugu rubripes) Stat4 genes revealed a high frequency of Ikaros (Ik) binding elements in all three species...
  10. ncbi The role of Ikaros in human erythroid differentiation
    Marilyne Dijon
    Centre de Thérapie Cellulaire et Génique, Institut Paoli Calmettes, Marseille, France
    Blood 111:1138-46. 2008
    b>Ikaros--a factor that positively or negatively controls gene transcription--is active in murine adult erythroid cells, and involved in fetal to adult globin switching. Mice with Ikaros mutations have defects in erythropoiesis and anemia...
  11. doi Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels
    Gen Kano
    Department of Paediatrics, Kyoto Prefectural University of Medicine, Japan
    Leuk Lymphoma 49:965-73. 2008
    b>Ikaros is an essential regulator of lymphocyte differentiation. Mice transgenic for the Ikaros dominant negative (DN) mutation rapidly develop lymphoid malignancies...
  12. doi Identification of different Ikaros cDNA transcripts in Philadelphia-positive adult acute lymphoblastic leukemia by a high-throughput capillary electrophoresis sizing method
    Ilaria Iacobucci
    Department of Hematology Oncology L and A Seràgnoli S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Haematologica 93:1814-21. 2008
    b>Ikaros is the prototypic member of a Kruppel-like zinc finger transcription factor subfamily that is required for normal hematopoietic cell differentiation and proliferation, particularly in the lymphoid lineages...
  13. doi Stage specific over-expression of the dominant negative Ikaros 6 reveals distinct role of Ikaros throughout human B-cell differentiation
    Cecile Tonnelle
    INSERM, U891, CRCM, Equipe Recherche Clinique, Marseille F 13009, France
    Mol Immunol 46:1736-43. 2009
    b>Ikaros is a transcription factor that acts both as an activator and as an inhibitor of gene expression in several hematopoietic lineages...
  14. doi Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leuke
    Ilaria Iacobucci
    Department of Hematology Oncology L and A Seràgnoli S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Blood 114:2159-67. 2009
    ..somatic copy number alteration was a focal deletion on 7p12 of IKZF1, which encodes the transcription factor Ikaros and was identified in 80 (75%) of 106 patients...
  15. pmc Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function
    Daniel Trageser
    Leukemia and Lymphoma Program, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90027, USA
    J Exp Med 206:1739-53. 2009
    ..clinical outcome among all ALL subtypes and is defined by the oncogenic BCR-ABL1 kinase and deletions of the IKAROS gene in >80% of cases...
  16. doi Deletions of the transcription factor Ikaros in myeloproliferative neoplasms
    R Jager
    Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Leukemia 24:1290-8. 2010
    ..We mapped the common deleted region to the IKZF1 gene, which encodes the transcription factor Ikaros. We further examined the frequency of IKZF1 deletions in a total of 29 post-MPN leukemia and 526 MPN patients ..
  17. ncbi Integrative genomic analyses on Ikaros and its expression related to solid cancer prognosis
    Liming Yang
    School of Life Sciences, Huaiyin Normal University, Huai An 223300, PR China or
    Oncol Rep 24:571-7. 2010
    b>Ikaros is a member of the Kruppel family of zinc finger DNA-binding proteins...
  18. doi Variation at 7p12.2 and 10q21.2 influences childhood acute lymphoblastic leukemia risk in the Thai population and may contribute to racial differences in leukemia incidence
    Jayaram Vijayakrishnan
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Leuk Lymphoma 51:1870-4. 2010
    ..g. IKZF1, rs4132601; risk allele frequency [RAF] ratio of 0.36 for Thai/Caucasian)...
  19. doi Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia
    E Waanders
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Radboud University Centre of Oncology and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Leukemia 25:254-8. 2011
    ..We analyzed MRD in 131 uniformly treated precursor-B-ALL patients and evaluated whether combined MRD and IKZF1 (Ikaros zinc finger-1) alteration status can improve risk stratification...
  20. doi Ikaros is degraded by proteasome-dependent mechanism in the early phase of apoptosis induction
    Li Cai He
    Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Biochem Biophys Res Commun 406:430-4. 2011
    b>Ikaros is an important transcription factor involved in the development and differentiation of hematopoietic cells...
  21. doi Expression of Ikaros isoform 6 in chinese children with acute lymphoblastic leukemia
    Fen Zhou
    Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China
    J Pediatr Hematol Oncol 33:429-32. 2011
    b>Ikaros is a zinc-finger transcription factor that plays an important role in the differentiation and proliferation of lymphocytes...
  22. pmc Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia
    E Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, Kiel, Germany
    Leukemia 26:902-9. 2012
    ..The identification of TP63 and PTPRJ as susceptibility genes emphasize the role of the TP53 gene family and the importance of proteins regulating cellular processes in connection with tumorigenesis...
  23. pmc Ikaros and tumor suppression in acute lymphoblastic leukemia
    Kimberly J Payne
    Loma Linda University, Loma Linda, California, USA
    Crit Rev Oncog 16:3-12. 2011
    The Ikzf1 gene encodes Ikaros-a DNA-binding zinc finger protein. Ikaros functions as a regulator of gene expression and chromatin remodeling...
  24. doi Expression of dominant-negative Ikaros isoforms and associated genetic alterations in Chinese adult patients with leukemia
    Ping Liu
    Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing, 210029, China
    Ann Hematol 91:1039-49. 2012
    Dominant-negative (DN) Ikaros isoforms, having important roles in pathogenesis of leukemia, are mainly studied in pediatric patients, but little is known about Chinese adult patients...
  25. pmc Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros
    Fatih M Uckun
    Division of Hematology Oncology, Systems Immunobiology Laboratory, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Proc Natl Acad Sci U S A 109:18072-7. 2012
    b>Ikaros is a zinc finger-containing DNA-binding protein that plays a pivotal role in immune homeostasis through transcriptional regulation of the earliest stages of lymphocyte ontogeny and differentiation...
  26. pmc Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations
    Heng Xu
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Natl Cancer Inst 105:733-42. 2013
    ..Although accumulating evidence indicates inherited predisposition to ALL, the genetic basis of ALL susceptibility in diverse ancestry has not been comprehensively examined...
  27. doi Association of three polymorphisms in ARID5B, IKZF1 and CEBPE with the risk of childhood acute lymphoblastic leukemia in a Chinese population
    Yaping Wang
    Department of Hematology and Oncology, Nanjing Children s Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China
    Gene 524:203-7. 2013
    ..in children younger than 15 years old, have found evidence that single nucleotide polymorphisms (SNPs) in IKZF1 (7p12.2), ARID5B (10q21.2) and CEBPE (14q11.2) are strongly related to the risk of childhood ALL...
  28. pmc ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
    Amy M Linabery
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Leuk Res 37:936-42. 2013
    Interactions between common germline variants in ARID5B and IKZF1 and other known childhood acute lymphoblastic leukemia (ALL) risk factors were queried using biospecimens and data from 770 ALL cases and 384 controls...
  29. doi Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype
    Gabriele Migliorini
    Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Blood 122:3298-307. 2013
    ..0001). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to BCP-ALL and the influence of constitutional genotype on disease development. ..
  30. pmc Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures
    Tiffany Jane Evans
    Centre for Bioinformatics, Biomarker Discovery and Information Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
    PLoS ONE 9:e110255. 2014
    Genome wide association studies (GWAS) have established association of ARID5B and IKZF1 variants with childhood acute lymphoblastic leukemia (ALL)...
  31. pmc Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia
    L Sun
    Parker Hughes Cancer Center, Children s Cancer Group ALL Biology Reference Laboratory, Departments of Genetics, Hughes Institute, St Paul, MN 55113, USA
    Proc Natl Acad Sci U S A 96:680-5. 1999
    b>Ikaros, a zinc finger-containing DNA-binding protein, is required for normal lymphocyte development, and germline mutant mice that express only non-DNA binding dominant-negative "leukemogenic" Ikaros isoforms lacking critical N-terminal ..
  32. ncbi Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis
    K J Payne
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital, Los Angeles, CA 90027, USA
    J Immunol 167:1867-70. 2001
    Murine studies implicate Ikaros proteins as regulators of hemopoiesis, particularly in the lymphoid lineages. High homology between murine and human Ikaros suggests that Ikaros expression in the two might be similar...
  33. ncbi A molecular dissection of the repression circuitry of Ikaros
    Joseph Koipally
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:27697-705. 2002
    b>Ikaros is a key regulator of the hemo-lymphoid system in which it is presumed to function by both potentiating and repressing gene expression...
  34. ncbi Non-DNA-binding Ikaros isoform gene expressed in adult B-precursor acute lymphoblastic leukemia
    K Nishii
    The Second Department of Internal Medicine, Mie University School of Medicine, Japan
    Leukemia 16:1285-92. 2002
    b>Ikaros, a zinc finger transcription factor, is essential for lymphoid development. Mutant mice expressing dominant-negative Ikaros gene (Ikaros) isoforms develop an aggressive form of lymphoid malignancies...
  35. pmc Ikaros isoforms in human pituitary tumors: distinct localization, histone acetylation, and activation of the 5' fibroblast growth factor receptor-4 promoter
    Shereen Ezzat
    Department of Medicine, Mount Sinai Hospital, University Health Network, University of Toronto, 610 University Avenue, 4 302, Toronto, Ontario, Canada M5G 2M9
    Am J Pathol 163:1177-84. 2003
    ..We have shown that FGFR4 is a target for Ikaros, a zinc finger-containing transcription factor that localizes to heterochromatin regions and participates in ..
  36. doi BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 453:110-4. 2008
    ..IKZF1 (encoding the transcription factor Ikaros) was deleted in 83.7% of BCR-ABL1 ALL, but not in chronic-phase CML...
  37. pmc Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
    Charles G Mullighan
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    N Engl J Med 360:470-80. 2009
    ..Recent genomewide analyses have identified a high frequency of DNA copy-number abnormalities in ALL, but the prognostic implications of these abnormalities have not been defined...
  38. pmc Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1
    Marcela Popescu
    Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53792 4108, USA
    J Biol Chem 284:13869-80. 2009
    b>Ikaros encodes a zinc finger protein that is involved in gene regulation and chromatin remodeling. The majority of Ikaros localizes at pericentromeric heterochromatin (PC-HC) where it regulates expression of target genes...
  39. pmc Germline genomic variants associated with childhood acute lymphoblastic leukemia
    Lisa R Treviño
    St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 41:1001-5. 2009
    ..86, respectively) and were associated with methotrexate accumulation and gene expression pattern in leukemic lymphoblasts. We conclude that germline variants affect susceptibility to, and characteristics of, specific ALL subtypes...
  40. pmc Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
    Elli Papaemmanuil
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 41:1006-10. 2009
    ..We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6...
  41. doi IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report
    Giovanni Martinelli
    Molecular Biology Unit, Department of Hematology and Oncology L and A Seràgnoli, University of Bologna, Via Massarenti, 9 40138 Bologna, Italy
    J Clin Oncol 27:5202-7. 2009
    ....
  42. doi Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood
    Rashmi B Prasad
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Blood 115:1765-7. 2010
    Recent genome-wide association data have implicated genetic variation at 7p12.2 (IKZF1), 10q21.2 (ARIDB5), and 14q11.2 (CEBPE) in the etiology of B-cell childhood acute lymphoblastic leukemia (ALL)...
  43. pmc Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia
    Richard C Harvey
    University of New Mexico Cancer Center and Departments of Pathology and Internal Medicine, University of New Mexico, Albuquerque, NM, USA
    Blood 115:5312-21. 2010
    ..rearrangements were significantly associated with activating mutations of JAK1 or JAK2, deletion or mutation of IKZF1, and Hispanic/Latino ethnicity (Fisher exact test, P < .001 for each)...
  44. doi IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL
    R P Kuiper
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Leukemia 24:1258-64. 2010
    ..In contrast, deletions and nonsense mutations in IKZF1 (IKAROS) were highly enriched and consistently preserved at the time of relapse...
  45. doi IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: a multicenter analysis in Taiwan
    Yung Li Yang
    Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Cancer Sci 102:1874-81. 2011
    ..Recent genome-wide analyses have identified that an alteration of IKZF1 is associated with very poor outcomes in B-cell progenitor ALL...
  46. doi CtBP1 interacts with Ikaros and modulates pituitary tumor cell survival and response to hypoxia
    Katie Dorman
    Departments of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Mol Endocrinol 26:447-57. 2012
    ..CtBP interacts with Ikaros isoforms in GH4 and AtT20 pituitary tumor cells...
  47. pmc Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study
    I Ming Chen
    Cancer Center and Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131 001, USA
    Blood 119:3512-22. 2012
    ..P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials ..
  48. pmc IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia
    Ilaria Iacobucci
    Department of Hematology and Oncological Sciences L and A Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    PLoS ONE 7:e40934. 2012
    Deletions of IKAROS (IKZF1) frequently occur in B-cell precursor acute lymphoblastic leukemia (B-ALL) but the mechanisms by which they influence pathogenesis are unclear...
  49. pmc Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase
    Hong Ma
    Systems Immunobiology Laboratory, Children s Center for Cancer and Blood Diseases, Children s Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e71302. 2013
    Diminished Ikaros function has been implicated in the pathogenesis of acute lymphoblastic leukemia (ALL), the most common form of childhood cancer...
  50. ncbi BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells
    F Klein
    Laboratory for Molecular Stem Cell Biology, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Oncogene 25:1118-24. 2006
    ..Consistent with this, BCR-ABL1+ pre-B lymphoblastic leukemia cells exhibit defective expression of IKAROS, a transcription factor needed for early lymphoid lineage commitment...
  51. ncbi [Mechanisms of action of class III anti-arrhythmia agents]
    M M Adamantidis
    Laboratoire de Pharmacologie, , Lille
    Arch Mal Coeur Vaiss 88:33-40. 1995
    ..the membrane potential (transient outward current Ito, delayed rectifying current IK and rectifying inward current IK1)...
  52. ncbi [Positive inotropic and lusitropic effect of RP 62719, a new class III antiarrhythmia agent]
    J P Beregi
    , , Loa-Ensta, Palaiseau
    Arch Mal Coeur Vaiss 87:263-9. 1994
    ..known to lengthen the duration of the cardiac action potential by selectively blocking the potassium current iK1 (inward rectifier K+ current)...
  53. pmc Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells
    S P Connors
    University Department of Pharmacology, Oxford
    Br J Pharmacol 106:958-65. 1992
    ..4. Compound II (1 microM) did not influence IK1 assessed from the current during ramp changes in membrane potential (20 mV s-1) over the range -90 to -10 mV. 5...
  54. ncbi The mouse BP-1 gene: structure, chromosomal localization, and regulation of expression by type I interferons and interleukin-7
    J Wang
    Howard Hughes Medical Institute, University of Alabama at Birmingham 35294, USA
    Genomics 33:167-76. 1996
    ..a TATA-like element and potential DNA-binding motifs for lymphocyte-specific transcription factors including Ikaros, BSAP, PU...
  55. ncbi Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors
    M K Boettger
    Peripheral Neuropathy Unit, Department of Neurology, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, UK
    Brain 125:252-63. 2002
    ..Blockade of IK1-like and other potassium channels by aminopyridines (4-AP and 3,4-DAP) may also explain the paraesthesiae induced ..
  56. ncbi Identification of two Ikaros-like transcription factors in lamprey
    W E Mayer
    Max Planck Institut fur Biologie, Abt Immungenetik, Corrensstr 42, 72076 Tubingen, Germany
    Scand J Immunol 55:162-70. 2002
    ..system in lampreys, we used the polymerase chain reaction (PCR) to identify genes for transcription factors of the Ikaros family in genomic DNA and cDNA libraries from two species of lampreys, Petromyzon marinus and Lampetra fluviatilis...
  57. ncbi Differential block of cardiac delayed rectifier current by class Ic antiarrhythmic drugs: evidence for open channel block and unblock
    C H Follmer
    Wyeth Ayerst Research, Division of Cardiovascular and Metabolic Disorders, Princeton, NJ 08543 8000
    Cardiovasc Res 26:1121-30. 1992
    ..The aim was to compare the effects of the class Ic antiarrhythmic drugs flecainide, encainide, and recainam on the delayed rectifier current, IK...
  58. ncbi ATP-dependent regulation of SK4/IK1-like currents in rat submandibular acinar cells: possible role of cAMP-dependent protein kinase
    M Hayashi
    Laboratory of Physiology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Am J Physiol Cell Physiol 286:C635-46. 2004
    SK4/IK1 encodes an intermediate conductance, Ca2+ -activated K+ channel and fulfills a variety of physiological functions in excitable and nonexcitable cells...
  59. pmc Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line
    Keiko Ishihara
    Department of Physiology, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Physiol 556:61-78. 2004
    ..Polyamines may regulate the amplitude of the outward I(K1), not only by blocking the channels but also by modifying the proportion of channels that show different sensitivities to the polyamine block...
  60. pmc The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins
    A Molnar
    Cutaneous Biology Research Center, Harvard Medical School, Massachusetts General Hospital, Charlestown 02129
    Mol Cell Biol 14:8292-303. 1994
    We previously described the lymphocyte-restricted Ikaros gene encoding a zinc finger DNA-binding protein as a potential regulator of lymphocyte commitment and differentiation...
  61. pmc Ikaros, a lymphoid-cell-specific transcription factor, contributes to the leukemogenic phenotype of a mink cell focus-inducing murine leukemia virus
    Nancy L DiFronzo
    Center for Virology, Immunology, and Infectious Disease Research, Children s National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA
    J Virol 76:78-87. 2002
    ..MCF 247 have not been identified, pathogenesis studies from our laboratory suggested to us that binding sites for Ikaros, a lymphoid-cell-restricted transcriptional regulator, affect the biological properties of MCF 247...
  62. ncbi Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels
    N A Castle
    Icagen Inc, Durham, North Carolina 27703, USA
    Mol Pharmacol 63:409-18. 2003
    ..from Scorpio maurus scorpion venom, was examined for its ability to inhibit cloned human SK (SK1, SK2, and SK3), IK1, and Slo1 calcium-activated potassium (K(Ca)) channels...
  63. ncbi The morphology, physiology and function of suboesophageal neck motor neurons in the honeybee
    Ulrike Schröter
    Visual Sciences, Research School of Biological Sciences, Australian National University, Canberra, ACT, Australia
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:289-304. 2007
    ..We studied neck motor neurons with cell bodies in the suboesophageal ganglion, axons in the first cervical nerve (IK1) and terminals in neck muscles 44 and 51 (muscle classification: Snodgrass in Smithsonian Misc Coll 103:1-120, 1942)..
  64. ncbi Order in disorder: effect of barium on ventricular fibrillation
    P Dorian
    Department of Medicine, University of Toronto, Ontario
    Can J Cardiol 12:399-406. 1996
    ..In particular, barium, a relatively selective blocker of cardiac Ik1 channels, produces marked decreases in defibrillation energy...
  65. ncbi Fc epsilon ri-mediated activation of transcription factors in antigen-presenting cells
    S Kraft
    Department of Dermatology, Friedrich Wilhelms University, Bonn, Germany
    Int Arch Allergy Immunol 125:9-15. 2001
    ..In addition, Ikaros and PU...
  66. ncbi [Action of AMP579 and adenosine on potassium or sodium ionic channels in isolated rat and guinea pig ventricular myocytes]
    Xiong Wang
    Department of Cardiology, First Hospital, Shanxi Medical University, Taiyuan 030001, China
    Yao Xue Xue Bao 41:716-20. 2006
    ..To study the effect of AMP579 and adenosine on potassium ionic (K+) or sodium ionic (Na+) channels and to elucidate ionic mechanisms underlying negative inotropic and antiarrhythmic effects of AMP579 and adenosine...
  67. pmc Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells
    Y Ohmoto-Sekine
    Department of Pharmacology, Chiba University School of Medicine, Japan
    Br J Pharmacol 126:751-61. 1999
    ..microM) inhibited the delayed rectifier K+ current (IK) with little influence on the inward rectifier K+ current (IK1) or the Ca2+ current...
  68. ncbi Fibroblast growth factor receptor 4 is a target for the zinc-finger transcription factor Ikaros in the pituitary
    ShunJiang Yu
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Mol Endocrinol 16:1069-78. 2002
    ..C (-64/-26) included potential binding sites for the hematopoietic zinc finger-containing transcription factor Ikaros (Ik) flanked by binding sites for Sp and Ets-type factors...
  69. ncbi Transgenic upregulation of IK1 in the mouse heart leads to multiple abnormalities of cardiac excitability
    Jingdong Li
    Dept of Molecular and Integrative Physiology, Univ of Michigan, Rm 7812 Medical Science II, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
    Am J Physiol Heart Circ Physiol 287:H2790-802. 2004
    To assess the functional significance of upregulation of the cardiac current (IK1), we have produced and characterized the first transgenic (TG) mouse model of IK1 upregulation. To increase IK1 density, a pore-forming subunit of the Kir2...
  70. ncbi Simulation of spontaneous action potentials of cardiomyocytes in pulmonary veins of rabbits
    Chang Ahn Seol
    Department of Physiology, University of Ulsan College of Medicine, 388 1 Poongnap dong Songpa ku, Seoul 138 736, Republic of Korea
    Prog Biophys Mol Biol 96:132-51. 2008
    ..Among the diverse ionic currents identified were INa, ICa,L, IK1, IKr, IKs, Ito, IKsus, Incx, Ipump, IKH and ICl,Ca...
  71. doi Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries
    Rob H P Hilgers
    Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Pharmacol Exp Ther 333:210-7. 2010
    ..K(Ca)), small-conductance calcium-activated K+ channel (SK3), and intermediate calcium-activated K+ channel (IK1)] before arterial structural remodeling...
  72. pmc Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
    Lynn Petukhova
    Department of Dermatology, Columbia University, New York, New York 10032, USA
    Nature 466:113-7. 2010
    ..antigen 4 (CTLA4), interleukin (IL)-2/IL-21, IL-2 receptor A (IL-2RA; CD25) and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region...
  73. doi Effect of processing treatments on the white spot syndrome virus DNA in farmed shrimps (Penaeus monodon)
    A Devivaraprasad Reddy
    Department of Fish Processing Technology, Fisheries College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Tuticorin, India
    Lett Appl Microbiol 52:393-8. 2011
    ..To investigate the effect of processing treatments on the destruction of white spot syndrome virus (WSSV) DNA in WSSV-infected farmed shrimps (Penaeus monodon)...
  74. ncbi Immunologic regulation of bone development
    Mark C Horowitz
    Yale University School of Medicine, Department of Orthopaedics and Rehabilitation, New Haven, CT, USA
    Adv Exp Med Biol 602:47-56. 2007
    A regulatory network comprised of transcription factors PU.1, Ikaros, E2A, EBF, and Pax5 control B cell fate specification and differentiation...
  75. ncbi Ikaros enforces the costimulatory requirement for IL2 gene expression and is required for anergy induction in CD4+ T lymphocytes
    Rajan M Thomas
    Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol 179:7305-15. 2007
    ..The IL2 promoter contains consensus-binding elements for Ikaros, a lymphocyte-specific zinc-finger DNA-binding protein that can regulate gene expression by recruiting chromatin-..
  76. pmc Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1
    A Tefferi
    Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 24:1128-38. 2010
    ..Sex Combs-Like 1 (ASXL1), Casitas B-lineage lymphoma proto-oncogene (CBL), Isocitrate dehydrogenase (IDH) and IKAROS family zinc finger 1 (IKZF1) have been described in BCR-ABL1-negative MPNs...
  77. pmc Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation
    Iskandar F Abdullaev
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, United States of America
    PLoS ONE 5:e12304. 2010
    ..Quantitative RT-PCR detected transcripts for the big conductance (BK), intermediate conductance (IK1), and small conductance (SK2) K(+) channels in two glioblastoma-derived cell lines and a surgical sample of ..
  78. pmc Effects of K+ channel blockers on the action potential of hypoxic rabbit myocardium
    E Ruiz Petrich
    Department of Physiology and Biophysics, Faculty of Medicine, University of Sherbrooke, , Canada
    Br J Pharmacol 106:924-30. 1992
    ..3. Tetraethylammonium (TEA, 10 mM) delayed but did not reduce APD shortening at the steady state. 4. Blocking of IK1 with a mixture of 0.2 mM Ba2+ and 4 mM Cs+ lengthened APD in normoxia and prevented APD95 shortening in hypoxia...
  79. ncbi Binding of Ikaros to germline Ig heavy chain gamma1 and epsilon promoters
    Lena Ström
    Department of Cell and Molecular Biology, Karolinska Institute, Box 285, SE 171 77 Stockholm, Sweden
    Mol Immunol 39:771-82. 2003
    ..b>Ikaros is an abundant nuclear protein expressed in hematopoietic cells...
  80. ncbi Transcriptional regulation of the mouse IL-7 receptor alpha promoter by glucocorticoid receptor
    Hai Chon Lee
    Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto, Japan
    J Immunol 174:7800-6. 2005
    ..Mouse IL-7Ralpha promoter has striking homology with human and rat, containing consensus motifs of Ikaros, PU.1, and Runx1 transcription factors...
  81. pmc IRF8 regulates B-cell lineage specification, commitment, and differentiation
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 112:4028-38. 2008
    PU.1, IKAROS, E2A, EBF, and PAX5 comprise a transcriptional network that orchestrates B-cell lineage specification, commitment, and differentiation...
  82. doi TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population
    C F He
    The First Affiliated Hospital, Anhui Medical University, Anhui, China
    Lupus 19:1181-6. 2010
    ..Five novel susceptibility genes (TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1) for SLE have been identified in a recent genome-wide association study of a Chinese Han population...
  83. ncbi The evolutionarily conserved avian Aiolos gene encodes alternative isoforms
    J Liippo
    Turku Graduate School of Biomedical Sciences, Turku Immunology Centre and Department of Medical Microbiology, University of Turku, Turku, Finland
    Eur J Immunol 29:2651-7. 1999
    Aiolos is an Ikaros-related lymphoid regulatory protein involved in B cell development and function...
  84. ncbi ATP release triggered by activation of the Ca2+-activated K+ channel in human airway Calu-3 cells
    Yasushi Ito
    Division of Respiratory Diseases, Department of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Am J Respir Cell Mol Biol 30:388-95. 2004
    ....
  85. ncbi Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray-induced mouse thymic lymphomas
    Mitsuaki A Yoshida
    Biodosimetry Section, Department of Radiation Dosimetry, Research Center for Radiation Emergency Medicine, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Cancer Genet Cytogenet 179:1-10. 2007
    ..for the mechanistic study of human acute lymphoblastic leukemia, show frequent LOH on chromosomes 4 (p15/p16), 11 (Ikaros), 12 (Bcl11b), 19 (Pten), and X. To date, however, little data are available regarding the mechanism of LOH...
  86. ncbi Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040, Madrid, Spain
    Cardiovasc Res 62:86-95. 2004
    ..In the present study, we examined whether angiotensin II (AngII) regulated the Ito as well as the putative intracellular cascade responsible for the effects...
  87. pmc Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation
    P Sabbattini
    Gene Regulation and Chromatin Group and Central Research Facility, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    EMBO J 20:2812-22. 2001
    The Ikaros family of proteins are DNA binding factors required for correct development of B and T lymphocytes...
  88. ncbi Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet
    Akira Harashima
    Fujisaki Cell Center, Hayashibara Biochemical Labs Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Leuk Res 29:841-8. 2005
    ..16 hematopoietic TFs: AML1, C/EBPalpha, C/EBPbeta, C/EBPgamma, C/EBPepsilon, E2A, Ets-1, GATA-1, GATA-2, GATA-3, Ikaros, IRF-1, Pax5, PU.1, T-bet and TCF-1 in 30 human BCP-leukemia cell lines...
  89. pmc Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel
    Jill Thompson
    Department of Pharmacology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Gen Physiol 127:159-69. 2006
    ..1 gene, and IK1 channels (KCa3.1)...
  90. ncbi Induction of alkaline phosphatase activity by L-ascorbic acid in human osteoblastic cells: a potential role for CK2 and Ikaros
    Eunwha Son
    Department of Herbal Medicine Resource, Institute of Bioscience and Biotechnology, Kangwon National University, Gangwon Do, Republic of Korea
    Nutrition 23:745-53. 2007
    ..The role of Ikaros and casein kinase 2 (CK2) in regulating osteoblast differentiation was also determined.
  91. doi Activation of cell migration with fibroblast growth factor-2 requires calcium-sensitive potassium channels
    Wolfram Kessler
    Klinik und Poliklinik für Allgemeine Chirurgie, Viszeral, Thorax und Gefasschirurgie, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Pflugers Arch 456:813-23. 2008
    ..FGF-2 also stimulates transcription of Ca(2+)-sensitive K(+) channels (IK1 or K(Ca)3.1), which are part of the migration machinery in many cell types...
  92. doi Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension
    Sebastian Brähler
    Department of Internal Medicine Nephrology, Philipps University, Marburg, Germany
    Circulation 119:2323-32. 2009
    It has been proposed that activation of endothelial SK3 (K(Ca)2.3) and IK1 (K(Ca)3.1) K+ channels plays a role in the arteriolar dilation attributed to an endothelium-derived hyperpolarizing factor (EDHF)...
  93. doi Crucial importance of the endothelial K+ channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction
    Malte Milkau
    Institut fur Physiologie, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    FASEB J 24:3572-9. 2010
    ..In EDHF signaling, endothelial hyperpolarization mediated by the Ca(2+)-activated K(+) channels SK3 and IK1 is a key step and also initiates gap junction-dependent conducted dilations...
  94. doi Berberine elicits anti-arrhythmic effects via IK1/Kir2.1 in the rat type 2 diabetic myocardial infarction model
    Li Hong Wang
    Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
    Phytother Res 25:33-7. 2011
    ..05); berberine recovered depressed Kir2.1 to nearly normal levels. The results suggest that the effects of berberine on I(K1)/Kir2.1 may be an important mechanism for producing anti-arrhythmic effects...
  95. pmc An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes
    Austin D E Swafford
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1041-4. 2011
    IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development of childhood acute lymphoblastic leukemia (C-ALL)...
  96. ncbi Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventricular cardiomyocytes
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Kashihara, Nara, Japan
    Arzneimittelforschung 53:407-13. 2003
    ..7 +/- 3.0% (n = 6, p < 0.01), and the inwardly rectifying K+ current (IK1) at -120 mV by 47.8 +/- 2.6% (n = 6, p < 0.01)...
  97. pmc Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene
    Martin Fuxa
    Research Institute of Molecular Pathology, Vienna Biocente, A 1030 Vienna, Austria
    Genes Dev 18:411-22. 2004
    ..He e we demonstrate that ectopic Pax5 expression from the Ikaros promote induces proximal rather than distal VH-DJH rearrangements in Ik(Pax5/+) thymocytes, thus recapitulating ..
  98. ncbi The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system
    L C Mongan
    Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK
    Neuroscience 131:161-75. 2005
    ..We show that SK1, SK2, SK3 and IK1 are all expressed in DRG and spinal cord...
  99. doi The inhibitory effect of acrylamide on NCAM expression in human neuroblastoma cells: involvement of CK2/Ikaros signaling pathway
    Hye Rim Lee
    Division of Immunopharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, Kyunggi Do, 440 746, Republic of Korea
    Toxicol In Vitro 24:1946-52. 2010
    ..Acrylamide dose-dependently decreased the DNA binding affinity of the Ikaros transcription factor, which is a bifunctional differentiation factor...
  100. ncbi Distinct signals control the hematopoiesis of lymphoid-related dendritic cells
    A Galy
    Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Blood 95:128-37. 2000
    ..DC was severely blocked when hematopoietic progenitors overexpressed Ik7, a mutant dominant-negative Ikaros protein...

Research Grants62

  1. Mark C Horowitz; Fiscal Year: 2014
    ..1, Ikaros, E2A, Ebf1, Pax5 and Gon4-like. With the exception of PU...
  2. Mechanisms underlying loss of neural stem cell competence.
    Minoree Kohwi; Fiscal Year: 2013
    ..Recent evidence indicates that Ikaros, the Hb orthologue in mammals, establishes early competence in mouse retinal progenitor cells, which undergo ..
  3. Stephen T Smale; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Ikaros is the founding member of a small family of C2H2 zinc finger DNA-binding proteins and has been found to play critical roles in lymphocyte development and tumor suppression...
  4. The role of E47 in uncommitted hematopoietic progenitors
    Lisa Borghesi; Fiscal Year: 2013
    ..identify two key genes as candidate E47 targets: the cell cycle regulator p21 and the transcriptional regulator Ikaros. Here, we propose to establish the mechanistic relationship between E47 and these two factors in primary bone ..
  5. Drew M Pardoll; Fiscal Year: 2014
    ..Recently, we identified Eos, a zinc-finger transcription factor of the Ikaros family, as a critical mediator of Foxp3-dependent gene silencing in Treg...
  6. GENOMIC ANALYSIS OF ADOLESCENT AND YOUNG ADULT ACUTE LYMPHOBLASTIC LEUKEMIA
    Cheryl L Willman; Fiscal Year: 2010
    ..seen in higher risk forms of pediatric ALL, including genetic alteration of the lymphoid transcription factor IKAROS, mutation of JAK kinases, and a gene expression signature associated with an extremely poor outcome...
  7. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Q Doe; Fiscal Year: 2012
    ..Because the mammalian Hunchback ortholog Ikaros has a similar role in specifying early-born retinal ganglion cell fates, this aim has the potential to hep design ..
  8. The role of Ikaros in regulation of Notch target gene expression
    SUSAN M WINANDY; Fiscal Year: 2010
    b>Ikaros is a nuclear protein and key regulator of T lymphopoiesis. Ikaros deficiency in mice results in abnormal T cell development and, with 100% penetrance, T cell leukemogenesis...
  9. Assembly and Trafficking of IK1 and SK3 in Endothelia
    Daniel C Devor; Fiscal Year: 2012
    ..they may be manipulated for clinical benefit requires us to answer the following questions: How are the number of IK1 and SK3 channels maintained at the plasma membrane, is this regulated by vasoactive agonists, what is the route of ..
  10. The Role of Ikaros in Regulatory T Cells that Protect Against Allergic Asthma
    SARAH UMETSU; Fiscal Year: 2011
    ..Preliminary experiments in our laboratory (see preliminary results section) have shown that in the absence of Ikaros, a transcription factor expressed in early T-cell progenitors as well as in mature T cells, the development of ..
  11. MICHAEL ARCHIBALD FARRAR; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Mutations in Ebf1, Pax5 and Ikaros, three transcription factors that form an interrelated gene network required to initiate B cell development, are frequently mutated in progenitor B-ALL...
  12. Chris Q Doe; Fiscal Year: 2016
    ..Because the mammalian Hunchback ortholog Ikaros has a similar role in specifying early-born retinal ganglion cell fates, this aim has the potential to hep design ..
  13. The Role of Zinc Finger Genes in Leukemogenesis
    Sinisa Dovat; Fiscal Year: 2013
    ..is to understand the malignant transformation of hematopoietic cells by identifying the biological functions of Ikaros proteins. Ikaros is essential for hematopoietic development and acts as a tumor suppressor...
  14. Ion Channel Characterization using Current Voltage Resonance Spectroscopy
    Steven Poelzing; Fiscal Year: 2010
    ..proposal is to validate impedance spectroscopy for simultaneously quantifying transsarcolemmal currents INa and IK1 in specific. We chose these two channels based on intriguing previous results our group obtained...
  15. Novel Role of a Nucleoporin Gene in Atrial Fibrillation, the Most Common Cardiac
    Qing Kenneth Wang; Fiscal Year: 2013
    ..Based on our new preliminary data that IK1 current densities are increased in NUP155 KO atrial myocytes compared to wild type control myocytes, here we ..
  16. Sathish Kumar; Fiscal Year: 2016
    ..for impaired EDHF-mediated vasodilation by determining mRNA and protein levels of EDHF components SK3 and IK1 channels and connexins (CX37, CX40, and CX47), their subcellular localization, and functional activity using ..
  17. Generation of Ikaros conditional knockout mice
    SUSAN M WINANDY; Fiscal Year: 2012
    ..b>Ikaros is a nuclear transcriptional regulator that is expressed almost exclusively in cells of the hematopoietic lineage ..
  18. Carolyn A Felix; Fiscal Year: 2014
    ..While overexpressed genes in the precursor/myeloid compartment featured lmo2, scl, cmyb, ikaros, rag2 and gata1, reduced expression of gata1 and other red cell genes was detected in the erythroid fraction, ..
  19. Role of CTCF in V(D)J Rearrangement
    STEPHANIE CHRISTINE DEGNER; Fiscal Year: 2010
    ..In addition, other factors involved in stage-specific looping of the Igh locus include Pax5, Ezh2, and Ikaros. Binding of these factors throughout immunoglobin loci will be examined by ChlP- Chip...
  20. Inward Rectifier Potassium Channels and Cardiac Excitability
    Anatoli N Lopatin; Fiscal Year: 2010
    ..Nevertheless, the mechanisms of IK1 regulation and the contribution of IK1 to AP under various physiologically important conditions remain largely ..
  21. Effects of K+ Accumulation/Depletion in the Heart
    Guy Salama; Fiscal Year: 2013
    ..K+]a responses will be compared during pharmacological interventions of channels responsible for K+ efflux (IK1, It,o, IK,slow, IKr, IKs, IKATP) and during manipulations of K+ re-uptake via the Na/K pumps...
  22. Katia Georgopoulos; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The DNA binding factor Ikaros and its chromatin remodeling associates of the Nucleosome Remodeling and Deacetylase (NuRD) complex control many key aspects of T cell differentiation and function ..
  23. Katia Georgopoulos; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Our recent studies indicate that the DNA binding factor Ikaros is required for pre-B cell transition from a proliferating to a differentiating phase...
  24. HETEROCHROMATIN RECRUITMENT OF THE VPAC1 LOCUS BY IKAROS
    Glenn Paul Dorsam; Fiscal Year: 2010
    The focus of this proposal is to investigate the molecular mechanisms governing Ikaros-mediated transcriptional regulation of vasoactive intestinal peptide receptor - 1 (VPACR-1) in T lymphocytes...
  25. FUNCTION OF THE SUBUNITS OF EUKARYOTIC CHROMOSOMES
    WILLIAM GARRARD; Fiscal Year: 2013
    ..we showed during the last funding cycle that this element is a recombination silencer responsible for recruiting Ikaros and targeting an Igk minilocus carried on a yeast artificial chromosome (YAC) to pericentromeric heterochromatin;(..
  26. Cheryl L Willman; Fiscal Year: 2015
    ..cohort of 500 high-risk ALL cases relative to the newly defined prognostic molecular abnormalities (involving IKAROS, JAK, CRLF2), and known risk factors (such as minimal residual disease) to develop a new molecular algorithm for ..
  27. Ikaros and Mi-2 beta interactions in early lymphoid development
    Katia Georgopoulos; Fiscal Year: 2013
    Abstract Our work to date has highlighted new and unexpected roles for Ikaros and its associate, the chromatin remodeler Mi-2[unreadable] in fate decisions made by hematopoietic stem cells and their early multipotent progeny...
  28. Role of IK channels in rat distal colon
    Vazhaikkurichi M Rajendran; Fiscal Year: 2010
    ..Although IK cDNA (that we have designated as IK1) has previously been cloned, we have made the following preliminary observations: 1) Isolation of a splice variant ..
  29. THE ROLE OF ZINC FINGER GENES IN HEMATOPOIESIS
    Sinisa Dovat; Fiscal Year: 2003
    ..and malignant transformation of hematopoietic cells by identifying biological functions of two genes, Ikaros and Helios. Ikaros encodes a zinc finger protein whose expression is restricted to hematopoietic cells...
  30. Molecular Determinants of Function in Kir2.x channels
    JUSTUS M ANUMONWO; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The inward rectifier current (IK1) plays a role in the excitability properties of the cardiac cell. Loss of function in one of the genes (KCNJ2) underlying the channel protein (Kir2...
  31. Unraveling germinal center B cell lymphoma development
    VINCENT TSIAGBE; Fiscal Year: 2007
    ..This promoter region has a binding site for the zinc-finger transcription factor, Ikaros, and the binding of Ikaros could results in the maintenance of condensed chromatin structure which would leads to ..
  32. ROLE OF CHROMATIN REMODELERS IN B AND T CELL DEVELOPMENT
    SAID SIF; Fiscal Year: 2004
    ..and T cell growth and differentiation through their interaction with the lymphoid specific transcription factors, Ikaros and Aiolos, in a cell cycle dependent manner...
  33. SPATIO-TEMPORAL PERIODICITY IN ARTIAL FIBRILLATION
    JOSE JALIFE; Fiscal Year: 2006
    ..2. To investigate LA-RA differences in IK,(ACh) and IK1 density in the atria of sheep and goat hearts, determine the role of such differences in establishing frequency- ..
  34. SCREEN FOR LYMPHOID MUTANTS
    Nikolaus Trede; Fiscal Year: 2004
    ..Lymphoid markers, including the earliest gene in lymphoid ontogeny Ikaros, are totally absent in thymi from CZ-3...
  35. RBC Ion Transporters as Hemoglobinopathy Risk Modifiers
    Seth Alper; Fiscal Year: 2009
    ..Among these activities already studied as therapeutic targets in sickle cell disease are the KCNN/IK1/SK4 Ca2+-activated K+ channel of intermediate conductance (Gardos channel), several types of KCC K-CI ..
  36. REGULATION OF SURROGATE LIGHT CHAIN IN AGED MICE
    Bonnie Blomberg; Fiscal Year: 2005
    ..of lambda5 and VpreB, the presence and function of transcription factors known (EBF and E47) and likely (Ikaros/Aiolos, Id) to be involved in lambda5/VpreB transcription regulation will be assayed by various methods including ..
  37. Molecular Basis of K+ Current During Secretion
    Keith Nehrke; Fiscal Year: 2002
    ..A candidate cDNA, termed SK4/IK1, was recently cloned based upon homology with the SK family of small-conductance calcium-activated potassium ..
  38. Computer Model of the Canine Ventricle
    Robert Gilmour; Fiscal Year: 2009
    ..Specifically, we will: 1) Experimentally characterize IKr, ICa, IK1, INaCa, and the late sodium current INa in myocytes obtained from specific regions of the ventricles...
  39. New drugs for treatment of atrial fibrillation
    Antonio Lacerda; Fiscal Year: 2004
    ..are to: 1) complete in vitro tests of the effects of the drug on other cardiac membrane currents ITo, IKs and IK1; 2) test the drug's efficacy in animal models of AF; 3) test the drug's safety in the cardiac muscle wedge ..
  40. Sickle Red Cell K+ Transporter Genetics in S. cerevisiae
    Seth Alper; Fiscal Year: 2002
    ..Activity of the KCC K-Cl cotransporters and the IK1 K(ca) channel mediates nearly all of this dehydration...
  41. Sex hormones modulate arrhythmogenesis in heart failure
    Steven Pogwizd; Fiscal Year: 2007
    ..Upregulated Na/Ca exchange (NCX) underlies greater I/ti, decreased inward rectifying K current (IK1) enhances the depolarization by I/ti and preserved beta-adrenergic receptor (beta-AR) responsiveness allows SR Ca ..
  42. Trans-acting factors in fetal hemoglobin silencing
    Merlin Crossley; Fiscal Year: 2006
    ..It has previously been reported that Ikaros plays a role in fetal globin silencing and we will also analyze a novel Ikaros mutant mouse bred to globin ..
  43. DOES VT BEGET VT? REMODELING IN HEALED INFARCTION
    David Callans; Fiscal Year: 2003
    ..measure steady state, peak activated and kinetic properties of Ik and ICaL and the current-voltage relations of Ik1 and InaCa...
  44. CARDIAC ELECTROPHYSIOLOGY--EFFECTS OF IONS AND DRUGS
    Ira Cohen; Fiscal Year: 1999
    ..application we propose to continue our studies of three Purkinje membrane currents: the inward rectifier current iK1, the pacemaker to a number of important questions...
  45. Lymphoid Transcription Factor in Striatal Development
    DENES AGOSTON; Fiscal Year: 2002
    ..and electrophoretic mobility shift assays (EMSA) demonstrated that the lymphoid zinc-finger transcription factor Ikaros, which controls T- and B-cell differentiation is specifically expressed in the developing striatum...
  46. LYMPHOTOXIN: REGULATION AND BIOLOGICAL SIGNIFICANCE
    NANCY RUDDLE; Fiscal Year: 2006
    ..reporter gene (Beta galactosidase or yellow fluorescent protein) knocked into the LTa locus; analyzing the role of Ikaros, a chromatin remodeling protein, in regulation of LTa and LTBeta with Ikaros knock-out and Ikaros...
  47. Studying cardiac IK1 using ion flux assays
    Anatoli Lopatin; Fiscal Year: 2009
    ..Recent studies have undoubtedly shown that IK1, the major inwardly rectifying potassium current in the heart, is a critical player in cardiac excitability...
  48. The molecular role of lkaros in leukemogenesis
    Susan Winandy; Fiscal Year: 2009
    ..We have identified Ikaros as a protein with characteristics of a novel T lineage specific tumor suppressor...
  49. Regulation of polarized Th responses in EAE by lkaros
    MARY QUIRION; Fiscal Year: 2009
    ..Recently, our laboratory demonstrated that Ikaros, a zinc-finger DMA binding transcription factor associated with chromatin remodeling, regulates II4 locus ..
  50. PROTEIN INTERACTIONS & HEMOPOIESIS FROM THE IKAROS POINT
    Katia Georgopoulos; Fiscal Year: 2000
    ..In particular, we would like to determine the role of the regulatory gene Ikaros in the events that control lineage commitment in the hemolymphopoietic system...
  51. The Role of Zinc Finger Genes in Cellular Proliferation
    Sinisa Dovat; Fiscal Year: 2007
    ..hematopoiesis and malignant transformation of hematopoietic cells by studying biological functions of two genes, Ikaros and Helios. Ikaros encodes a zinc finger protein involved in heritable gene silencing...
  52. Ikaros regulatory networks in hematopoiesis
    LEE LAWTON; Fiscal Year: 2007
    Deficiency in the Ikaros gene causes a reduction in hematopoietic stem cells (HSCs) and specific defects in lymphocyte differentiation including the development of leukemias and lymphomas...
  53. Role of Ikaros in IL-2 gene expression and T cell anergy
    Andrew Wells; Fiscal Year: 2005
    ..We find that the IL-2 promoter contains two putative binding motifs for Ikaros, a lymphoid-specific zinc-finger DNA binding protein required for normal T lymphocyte development...
  54. Role of Potassium Channels in Fibrillatory Conduction
    JOSE JALIFE; Fiscal Year: 2009
    ..1) protein responsible for IK1: i) a variant of short QT syndrome, SQTS3, resulting from a mutation (D172) that increases risk of sudden cardiac ..
  55. The Helios Gene in Development and Homeostasis of Skin
    Bruce Morgan; Fiscal Year: 2009
    ..This project examines the role of Helios, a member of the Ikaros gene family, in this process...
  56. The Physiological Roles of K Channels in Fluid Secretion
    TED B BEGENISICH; Fiscal Year: 2010
    ..Salivary glands contain two types of calcium-activatedK channels named IK1 and maxi-K...
  57. Mechanisms of Arrhythmia in the Setting of Heart Failure
    Steven Pogwizd; Fiscal Year: 2007
    ..to decreased phospholamban (PLB) phosphorylation) can be enhanced without increased arrhythmogenesis; and enhancing IK1 in HF may be antiarrhythmic but may be negatively inotropic; 3) In vivo whole heart gene transfer can provide proof-..
  58. Application for a Fluorescence-Activated Cell Sorter
    ELLEN ROTHENBERG; Fiscal Year: 2003
    ..This application is to replace the old sorter with a new sorter that will improve service to existing clients and permit the Facility to carry out new flow cytometric applications that have not been available to the user group before. ..
  59. CIS-REGULATORY ANALYSIS OF PU.1 BY IN VITRO ES CELL DIFFERENTIATION
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..This should permit faster and cheaper experiments to reveal how powerful regulatory genes are themselves controlled. [unreadable] [unreadable]..
  60. GATA-3 in precursor commitment to the T lineage
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..Definition of mechanistic requirements for GATA-3 perturbation of T-cell development 3. Attempted rescue of GATA-3 overexpression effects by cotransduction with targets of specific repression ..