IKBKE

Summary

Gene Symbol: IKBKE
Description: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Alias: IKK-E, IKK-i, IKKE, IKKI, I-kappa-B kinase epsilon, IKK-epsilon, IKK-related kinase epsilon, inducible I kappa-B kinase, inducible IkappaB kinase
Species: human

Top Publications

  1. ncbi Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 437:1167-72. 2005
  2. pmc A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
    Bigang Liu
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 103:17202-7. 2006
  3. ncbi IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Nat Immunol 4:491-6. 2003
  4. pmc IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 286:37389-98. 2011
  5. doi MIP-T3 is a negative regulator of innate type I IFN response
    Ming Him James Ng
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Immunol 187:6473-82. 2011
  6. pmc Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage
    Rongtuan Lin
    Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Quebec, Canada
    J Virol 80:6072-83. 2006
  7. ncbi IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex
    R T Peters
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell 5:513-22. 2000
  8. pmc SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
    Grigory Ryzhakov
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 26:3180-90. 2007
  9. pmc Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling
    Fumitaka Fujita
    Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, Mizuho ku, Nagoya 467 8601, Japan
    Mol Cell Biol 23:7780-93. 2003
  10. pmc SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
    Jun Huang
    College of Life Sciences, Peking University, Beijing, China
    EMBO J 24:4018-28. 2005

Scientific Experts

Detail Information

Publications141 found, 100 shown here

  1. ncbi Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 437:1167-72. 2005
    ..Cardif thus functions as an adaptor, linking the cytoplasmic dsRNA receptor RIG-I to the initiation of antiviral programmes...
  2. pmc A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
    Bigang Liu
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 103:17202-7. 2006
    ..Thus, overexpression of IKKalpha in the epidermis antagonized chemical carcinogen-induced mitogenic and angiogenic activities, repressing tumor progression and metastases...
  3. ncbi IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Nat Immunol 4:491-6. 2003
    ..Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response...
  4. pmc IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 286:37389-98. 2011
    ..Activation of Akt by mitogenic factor depends on phosphatidylinositol 3-kinase (PI3K). Here, we report that IKBKE (also known as IKKε and IKKi) activates Akt through a PI3K-independent pathway...
  5. doi MIP-T3 is a negative regulator of innate type I IFN response
    Ming Him James Ng
    Department of Biochemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Immunol 187:6473-82. 2011
    ..Our findings suggest that MIP-T3 functions as a negative regulator of innate IFN response by preventing TRAF3 from forming protein complexes with critical downstream transducers and effectors...
  6. pmc Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage
    Rongtuan Lin
    Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Quebec, Canada
    J Virol 80:6072-83. 2006
    ..These observations provide an outline of the mechanism by which hepatitis C virus evades the interferon antiviral response...
  7. ncbi IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex
    R T Peters
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell 5:513-22. 2000
    Here we report the identification of a novel PMA-inducible IkappaB kinase complex, distinct from the well-characterized high-molecular weight IkappaB kinase complex containing IKKalpha, IKKbeta, and IKKgamma...
  8. pmc SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK
    Grigory Ryzhakov
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 26:3180-90. 2007
    ..Activation of IRF3 requires its phosphorylation by TBK1 (TANK-binding kinase) or IKKi (inhibitor of nuclear factor kappaB kinase, inducible)...
  9. pmc Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling
    Fumitaka Fujita
    Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, Mizuho ku, Nagoya 467 8601, Japan
    Mol Cell Biol 23:7780-93. 2003
    ..Here we identify NAP1 (for NAK-associated protein 1), a protein that interacts with NAK and its relative IKK epsilon (also known as IKKi). NAP1 activates NAK and facilitates its oligomerization...
  10. pmc SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
    Jun Huang
    College of Life Sciences, Peking University, Beijing, China
    EMBO J 24:4018-28. 2005
    ..These findings suggest that SIKE is a physiological suppressor of IKKepsilon and TBK1 and plays an inhibitory role in virus- and TLR3-triggered IRF-3 but not NF-kappaB activation pathways...
  11. ncbi Integrative genomic approaches identify IKBKE as a breast cancer oncogene
    Jesse S Boehm
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 129:1065-79. 2007
    ..Whole genome structural analyses reveal that one of these kinases, IKBKE (IKKepsilon), is amplified and overexpressed in breast cancer cell lines and patient-derived tumors...
  12. ncbi Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
    Beichu Guo
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California 90095, USA
    J Biol Chem 282:11817-26. 2007
    ..adaptor inducing interferon-beta), and TRAF3 and downstream mediators TANK-binding kinase 1, inducible IkappaB kinase, and interferon regulatory factor 3...
  13. doi The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
    Teresa L M Thurston
    Medical Research Council Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, UK
    Nat Immunol 10:1215-21. 2009
    ..We conclude that human cells utilize the ubiquitin system and NDP52 to activate autophagy against bacteria attempting to colonize their cytosol...
  14. pmc IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation
    Xiaoduo Xie
    Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:6474-9. 2011
    ..Our observations suggest a physiological function of IKKε/TBK1 in AKT regulation and a possible mechanism of IKKε/TBK1 in oncogenesis by activating AKT...
  15. doi Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?
    Tieu Lan Chau
    Interdisciplinary Cluster for Applied Genoproteomics, University of Liege, Sart Tilman, 4000 Liege, Belgium
    Trends Biochem Sci 33:171-80. 2008
    ..Moreover, increasing evidence indicates that distinct scaffold proteins assemble IKK, and potentially TBK1 and IKK-epsilon subcomplexes, in a stimulus-specific manner, which might be a mechanism to achieve specificity...
  16. pmc Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation
    Jessica E Hutti
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 34:461-72. 2009
    ..Together, these observations define IKKepsilon and CYLD as an oncogene-tumor suppressor network that participates in tumorigenesis...
  17. pmc The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
    Constantin S Friedman
    Immunology Institute, Mount Sinai School of Medicine, Box 1630, One Gustave L Levy Place, New York, New York 10029, USA
    EMBO Rep 9:930-6. 2008
    ..These findings show that CYLD is a negative regulator of RIG-I-mediated innate antiviral response...
  18. pmc Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation
    Martina Schröder
    Viral Immune Evasion Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO J 27:2147-57. 2008
    ..Therefore, this study shows for the first time the involvement of a DEAD box helicase in TBK1/IKKepsilon-mediated IRF activation and Ifnb promoter induction...
  19. ncbi IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation
    Mazhar Adli
    Lineberger Comprehensive Cancer Center, Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 281:26976-84. 2006
    ..The data indicate a role for IKK-i/IKKepsilon in controlling proliferation of certain cancer cells through regulation of constitutive NF-kappaB activity...
  20. pmc Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter
    Suzanne Paz
    Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Mol Cell Biol 29:3401-12. 2009
    ..These results provide further support for the differential role of IKKepsilon and TBK-1 in the RIG-I/Mda5 pathway...
  21. ncbi The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways
    Tiejun Zhao
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal H3T 1E2, Canada
    Nat Immunol 8:592-600. 2007
    ..IRF3 phosphorylation and interferon production were restored by ectopic expression of NEMO. Thus, NEMO, like MAVS, acts as an adaptor protein that allows RIG-I to activate both the NF-kappaB and IRF signaling pathways...
  22. doi Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis
    R Dieguez-Gonzalez
    Laboratorio de Investigacion 2 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
    Ann Rheum Dis 68:579-83. 2009
    ..To examine genetic association between rheumatoid arthritis (RA) and known polymorphisms in core genes of the nuclear factor (NF)kappaB pathway, the major intracellular pathway in RA pathogenesis...
  23. ncbi Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK
    Holger Buss
    Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 279:55633-43. 2004
    ....
  24. doi FOXO3 as a new IKK-ε-controlled check-point of regulation of IFN-β expression
    Lionel Luron
    Kennedy Institute of Rheumatology, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Eur J Immunol 42:1030-7. 2012
    ..Thus, we identify FOXO3 as a new IKK-ε-controlled check-point of IRF activation and regulation of IFN-β expression, providing new insight into the role of FOXO3 in immune response control...
  25. pmc ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling
    Linlin Gao
    Department of Microbiology and Immunology, Graduate Program in Cancer Biology, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 286:36592-602. 2011
    ..molecule TAX1BP1 and was essential for the recruitment of TAX1BP1 and A20 to the noncanonical IκB kinases TBK1 and IKKi in response to poly(I:C) transfection...
  26. ncbi IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases
    T Shimada
    Department of Biochemistry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Int Immunol 11:1357-62. 1999
    ..These results suggest that IKK-i is an inducible IkappaB kinase which may play a special role in the immune response.
  27. ncbi IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2
    Nandini Kishore
    Department of Arthritis and Inflammation Pharmacology, Discovery Research, Pharmacia Corporation, St Louis, Missouri 63167, USA
    J Biol Chem 277:13840-7. 2002
    ..Thus, although these IKKs are structurally similar, their enzymatic properties may provide insights into their unique functions...
  28. pmc Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer
    Jian Ping Guo
    Departments of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Am J Pathol 175:324-33. 2009
    I-kappa-B kinase e (IKBKE; IKKepsilon) has been recently identified as a breast cancer oncogene, and its alteration appears to be an early event in breast cancer development...
  29. pmc Genetic dissection of interferon-antagonistic functions of rabies virus phosphoprotein: inhibition of interferon regulatory factor 3 activation is important for pathogenicity
    Martina Rieder
    Max von Pettenkofer Institute and Gene Center, Ludwig Maximilians University, D 81377 Munchen, Germany
    J Virol 85:842-52. 2011
    ..182 to 186, or 176 to 186 were severely compromised in counteracting phosphorylation of IRF3 and IRF7 by TBK1 or IKKi while retaining the full capacity of preventing nuclear import of activated STATs and of supporting virus ..
  30. pmc TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections
    Andrea K Miyahira
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    J Immunol 182:2248-57. 2009
    TANK-binding kinase-1 (TBK1) and the inducible IkappaB kinase (IKK-i) have recently been shown to activate type I IFN responses elicited by intracellular detection of RNA or DNA from infecting viruses...
  31. pmc Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
    Jean François Clément
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada
    J Virol 82:3984-96. 2008
    The IkappaB kinase-related kinases, TBK1 and IKKi, were recently shown to be responsible for the C-terminal phosphorylation of IRF-3. However, the identity of the phosphoacceptor site(s) targeted by these two kinases remains unclear...
  32. doi Intrinsic pathway of apoptosis in peripheral blood eosinophils of Churg-Strauss syndrome
    Bogdan Jakiela
    Department of Medicine, Jagiellonian University Medical College, ul Skawinska 8, 31 066 Krakow, Poland
    Rheumatology (Oxford) 48:1202-7. 2009
    ..We wondered whether eosinophil accumulation in CSS results from the defect of intrinsic apoptosis pathway in blood eosinophils, leading to their prolonged survival...
  33. pmc RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2
    Akihiko Komuro
    Pancoe ENH Research Pavilion, Northwestern University, 2200 Campus Drive, Evanston, IL 60208, USA
    J Virol 80:12332-42. 2006
    ..Experiments suggest that LGP2 can compete with the kinase IKKi (also known as IKKepsilon) for a common interaction site on IPS-1...
  34. doi Phytoestrogen bavachin mediates anti-inflammation targeting Ikappa B kinase-I kappaB alpha-NF-kappaB signaling pathway in chondrocytes in vitro
    Cheng Chung Cheng
    Division of Cardiology, Department of Medicine, Tri Service General Hospital, Taiwan, ROC
    Eur J Pharmacol 636:181-8. 2010
    ..Our results suggest that through decreasing IL-1 beta-induced activation of IKK-I kappaB alpha-NF-kappaB signaling pathway, bavachin potentially protects cartilage from inflammation-mediated damage in joints of osteoarthritis patients...
  35. ncbi IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    Taro Kawai
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency
    Nat Immunol 6:981-8. 2005
    ..TBK1 and IKKi protein kinases were required for the IPS-1-mediated interferon induction...
  36. doi Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein
    Junyi Jiang
    Key Laboratory of Infection and Immunity of Chinese Academy of Sciences, Institute of Biophysics, Beijing 100101, China
    Protein Cell 1:1106-17. 2010
    ..with CARDIF, TRIF, NEMO, TBK1, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (IKKi) and interferon regulatory factor 3 (IRF3)...
  37. pmc Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes
    Fumiyo Ikeda
    Institute of Biochemistry II, Goethe University Medical School, Frankfurt, Germany
    EMBO J 26:3451-62. 2007
    ..We propose that the ULD is a regulatory component of the TBK1/IKK-i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways...
  38. ncbi Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells
    Kosuke Matsui
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    J Immunol 177:5785-9. 2006
    TANK-binding kinase 1 (TBK1) and inducible IkappaB kinase (IKK-i) are involved in the activation of transcription factors inducing the production of type I IFNs...
  39. ncbi Upregulation of stress-response genes with cell cycle arrest induced by carbon ion irradiation in multiple murine tumors models
    Kaori Imadome
    RadGenomics Project, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Cancer Biol Ther 7:208-17. 2008
    ..To elucidate the in vivo biological effects induced by carbon-ion irradiation using comprehensive expression analysis...
  40. ncbi Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77
    Liming Pei
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 20:786-94. 2006
    ..One particularly interesting Nur77-responsive gene is the inducible kinase IKKi/IKKepsilon, an important component of the NF-kappaB signaling pathway...
  41. ncbi IRF-7: new role in the regulation of genes involved in adaptive immunity
    Marco Sgarbanti
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann N Y Acad Sci 1095:325-33. 2007
    ..The so far unrecognized role of IRF-7 in LMP-2 stimulation points to IRF-7 as a transcriptional regulator that bridges innate and adaptive immunity...
  42. doi Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells
    Simone Reuter
    Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hopital Kirchberg, Luxembourg, Luxembourg
    Ann N Y Acad Sci 1171:436-47. 2009
    ..of 29 NF-kappaB-related mRNAs was significantly downregulated (CARD4, CCL2, CD40, CSF2, F2R, ICAM1, IKBKB, IKBKE, IL1A, IL1B, IL6, IL8, IRAK2, MALT1, MAP3K1, MYD88, NFKB1, NFKB2, NFKBIA, PPM1A, RAF1, RELB, STAT1, TLR3, TNF, ..
  43. pmc Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1
    Kathleen C Prins
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 83:3069-77. 2009
    ....
  44. doi IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling
    Grigory Ryzhakov
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, London W6 8LH, United Kingdom
    J Immunol 189:4852-8. 2012
    ..On the whole, our study demonstrates that Act1 is a component of antiviral signaling...
  45. doi TRAF-mediated regulation of immune and inflammatory responses
    Yaya Wang
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, USA
    Sci China Life Sci 53:159-68. 2010
    ....
  46. doi Posttranslational regulation of Abcc2 expression by SUMOylation system
    Satoko Minami
    Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Physiol Gastrointest Liver Physiol 296:G406-13. 2009
    ..all of these interactions were abolished by substituting the putative SUMO consensus site in the linker region (IKKE) in Abcc2 to IRKE...
  47. pmc A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response
    Suzanne Paz
    Terry Fox Molecular Oncology Group, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec H3T1E2, Canada
    Cell Res 21:895-910. 2011
    ..This study demonstrates that MAVS harbors a functional C-terminal TRAF3-binding site that participates in positive and negative regulation of the IFN antiviral response...
  48. pmc IKKα negatively regulates ASC-dependent inflammasome activation
    Bradley N Martin
    1 Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA 2 Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA 3
    Nat Commun 5:4977. 2014
    ..Mechanistically, the downstream nuclear effector IKK-related kinase (IKKi) facilitates translocation of ASC from the nucleus to the perinuclear area during inflammasome activation...
  49. pmc Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase
    Feici Diao
    College of Life Sciences, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 104:11706-11. 2007
    ..These findings suggest that DAK is a physiological suppressor of MDA5 and specifically inhibits MDA5- but not RIG-I-mediated innate antiviral signaling...
  50. ncbi FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 11:791-7. 2003
    ..KIAA0456 cDNA was found derived from the FNBP2 gene, consisting of 22 exons. FNBP2 gene was linked to IKBKE and NORE1 genes on human chromosome 1q32.1...
  51. doi The IKK-related kinases: from innate immunity to oncogenesis
    Jean François Clément
    Faculte de Pharmacie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Cell Res 18:889-99. 2008
    ..highly influenced by the discovery of the IkappaB kinase (IKK)-related kinases, TANK Binding Kinase 1 (TBK1) and IKKi, which regulate the activity of interferon regulatory factor (IRF)-3/IRF-7 and NF-kappaB transcription factors...
  52. doi SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death
    Florian Renner
    Medical Faculty, Institute of Biochemistry, Friedrichstrasse 24, Justus Liebig University, 35392 Giessen, Germany
    Mol Cell 37:503-15. 2010
    ..SUMO modification of IKKepsilon is required to trigger phosphorylation of nuclear substrates including NF-kappaB p65, thereby contributing to the antiapoptotic function of NF-kappaB in response to DNA damage...
  53. ncbi Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease
    John Hiscott
    Lady Davis Institute for Medical Research Jewish General Hospital, Department of Microbiology and Immunology, McGill University, Montreal, Canada H3T 1E2
    Biochem Pharmacol 72:1477-84. 2006
    ..Cys508Ala) is not cleaved from the mitochondria by active protease; and (4) the virus-induced IKK epsilon kinase, but not TBK1, co-localizes strongly with MAVS at the mitochondrial membrane and the localization of ..
  54. pmc Functionally distinct effects of the C-terminal regions of IKKε and TBK1 on type I IFN production
    Yuichiro Nakatsu
    Department of Virology III, National Institute of Infectious Diseases, Musashi Murayama, Tokyo, Japan
    PLoS ONE 9:e94999. 2014
    ..The results highlight the importance of the C-terminal region in the functional activity of IKKε in innate immune response and also the difference in activation mechanisms between IKKε and the closely related TBK1...
  55. ncbi Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells
    Sean F Eddy
    Department of Biochemistry, Boston University School of Medicine, MA 02118, USA
    Cancer Res 65:11375-83. 2005
    ..Thus, CK2 induces functional IKK-i/IKKepsilon, which is an important mediator of the activation of NF-kappaB that plays a critical role in the pathogenesis of breast cancer...
  56. ncbi All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex
    R Heilker
    Novartis Pharma AG, Arthritis and Bone Metabolism Research, Basel, Switzerland
    Eur J Biochem 259:253-61. 1999
    ..Therefore, both p90rsk1 and CK II have the same preference for phosphorylating only one of the two serines which are relevant for inducible degradation...
  57. doi KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas
    Yingduan Cheng
    Department of Clinical Oncology, State Key Laboratory in Oncology in South China Cancer Epigenetics Laboratory, Sir YK Pao Center for Cancer, Hong Kong Cancer Institute, Chinese University of Hong Kong, Shatin, Hong Kong
    Cancer Res 70:6516-26. 2010
    ..oncogenes including MYC, MITF, HMGA2, and CDK6, as well as the NF-kappaB upstream factors STAT3, STAT5B, ID1, and IKBKE, most likely through heterochromatin silencing...
  58. ncbi Signal transduction in human cutaneous melanoma and target drugs
    Anatoly B Uzdensky
    194 1 Stachky ave, NII NK, Rostov on Don, 344090, Russia
    Curr Cancer Drug Targets 13:843-66. 2013
    ..Inhibitors of these pathways may serve as promising tools for anti-melanoma targeted therapy. Some novel anti-melanoma target drugs are characterized. ..
  59. ncbi Chlamydia pneumoniae activates IKK/I kappa B-mediated signaling, which is inhibited by 4-HNE and following primary exposure
    Bernadette Donath
    Institute of Clinical Chemistry and Pathobiochemistry, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munchen, Germany
    Atherosclerosis 165:79-88. 2002
    ..C. pneumoniae-induced NF-kappa B activation as well as the inhibition of that effect under certain conditions may contribute to chronic inflammation with potential relevance to vascular disease...
  60. pmc IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis
    Peyman Nakhaei
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Canada
    J Virol 86:726-37. 2012
    ..Our findings reveal a novel function of IKKε as a regulator of the virus-induced triggering of apoptosis via the phosphorylation-dependent turnover of XIAP...
  61. pmc NF-κB activation coordinated by IKKβ and IKKε enables latent infection of Kaposi's sarcoma-associated herpesvirus
    Zhiheng He
    Department of Molecular Microbiology and Immunology, Keck Medical Center, University of Southern California, Los Angeles, California, USA
    J Virol 88:444-55. 2014
    ..Our findings uncover a scheme wherein NF-κB activation is coordinated by IKKβ and IKKε, which sequentially phosphorylate RelA in a site-specific manner to enable latent infection after KSHV de novo infection. ..
  62. pmc Coregulation mapping based on individual phenotypic variation in response to virus infection
    German Nudelman
    Center for Translational Systems Biology and Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunome Res 6:2. 2010
    ..after Gene Ontology filtering, indicated the existence of two clusters of genes (CCL5, IFNA1, IFNA2, IFNB1) and (IKBKE, IL6, IRF7, MX1) that were transcriptionally co-regulated...
  63. doi NF-κB pathway is involved in CRP-induced effects on pulmonary arterial endothelial cells in chronic thromboembolic pulmonary hypertension
    Marijke Wynants
    Respiratory Division, Dept of Clinical and Experimental Medicine KU Leuven, Onderwijs and Navorsing 1 Box 706, Herestraat 49, B 3000 Leuven, Belgium
    Am J Physiol Lung Cell Mol Physiol 305:L934-42. 2013
    ..nonstimulated PAEC, serotonin receptor 2B was downregulated by 25%, inhibitor of NF-κB kinase subunit epsilon (IKBKE) by 30%, and toll-like receptor-4 and -6 by 18 and 39%, respectively, in CRP-stimulated PAEC...
  64. ncbi NF-kappaB activation upon interaction of HIV-1 envelope glycoproteins with cell surface CD4 involves IkappaB kinases
    Guillaume Bossis
    Laboratoire Infections Retrovirales et Signalisation Cellulaire, CNRS UMR 5121, Institut de Biologie, 4 Bd Henri IV, 34060, Montpellier, France
    FEBS Lett 516:257-64. 2002
    ..Taken together, these results confirm that IKKs complex play a key role in gp120(env)-induced NF-kappaB activation...
  65. ncbi Kinetic mechanisms of IkappaB-related kinases (IKK) inducible IKK and TBK-1 differ from IKK-1/IKK-2 heterodimer
    Q Khai Huynh
    Department of Arthritis and Inflammation Pharmacology, Discovery Research, Pharmacia Corporation, Mailzone T3M, 800 North Lindbergh Blvd, St Louis, MO 63167, USA
    J Biol Chem 277:12550-8. 2002
    ..87 microm), followed by rhIKK-i (K(IkappaBalpha) = 5.47 microm) and rhIKK-1/rhIKK-2 heterodimers (K(IkappaBalpha) = 0.12 microm). Thus this family of IkappaB kinases has very unique kinetic properties...
  66. doi Systematic characterization by mass spectrometric analysis of phosphorylation sites in IRF-3 regulatory domain activated by IKK-i
    Kiyonaga Fujii
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 12, W 6, Kita ku, Sapporo 060 0812, Japan
    J Proteomics 73:1196-203. 2010
    ..Thus, we demonstrated that Ser-386, -396 and -402 are directly phosphorylated by IKK-i in the co-expression system. These results will help provide new insights into the IRF-3 activation mechanism...
  67. pmc IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex
    Alicia Y Zhou
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell Rep 3:724-33. 2013
    IκB kinase ε (IKKε, IKBKE) is a key regulator of innate immunity and a breast cancer oncogene, amplified in ~30% of breast cancers, that promotes malignant transformation through NF-κB activation...
  68. pmc The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
    Mihir Rajurkar
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:E1038-47. 2012
    ..Interestingly, we demonstrate Gli-regulated I-kappa-B kinase epsilon (IKBKE) and NF-κB activity in pancreatic cancer cells and show that this activity is a critical downstream mediator for ..
  69. ncbi Interferon response induced by Toll-like receptor signaling
    Osamu Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Endotoxin Res 10:252-6. 2004
    ..These observations demonstrate that IKK-i/TBK1 signaling is essential for both TLR3-dependent and TLR3-independent viral and dsRNA-induced IFN responses...
  70. pmc Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis
    E Croze
    1 Global Medical Affairs, Bayer HealthCare Pharmaceuticals, San Francisco, CA, USA 2 International Review of Investigational Science, Lafayette, CA, USA
    Pharmacogenomics J 13:443-51. 2013
    ..Network analysis highlighted IKBKE, which likely has a role in both viral response and energy metabolism...
  71. doi Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions
    Pasi Kaukinen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Helsinki, Finland
    J Med Virol 85:71-82. 2013
    ..The present study identified HCV NS2 as a potent interferon antagonist, and describes an explanation of how NS2 downregulates the major signaling pathways involved in the development of host innate antiviral responses...
  72. ncbi Regulation and function of IKK and IKK-related kinases
    Hans Hacker
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Sci STKE 2006:re13. 2006
    ..Together, the IKKs and IKK-related kinases are instrumental for activation of the host defense system. This Review focuses on the functions of IKK and IKK-related kinases and the molecular mechanisms that regulate their activities...
  73. ncbi The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members
    Jikun Zha
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China
    J Immunol 176:1072-80. 2006
    ..Taken together, our findings suggest that RFP negatively regulates signaling involved in the antiviral response and inflammation by targeting the IKKs...
  74. pmc IKKi deficiency promotes pressure overload-induced cardiac hypertrophy and fibrosis
    Jia Dai
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
    PLoS ONE 8:e53412. 2013
    The inducible IκB kinase (IKKi/IKKε) is a recently described serine-threonine IKK-related kinase. Previous studies have reported the role of IKKi in infectious diseases and cancer...
  75. ncbi A20 is a negative regulator of IFN regulatory factor 3 signaling
    Tatsuya Saitoh
    Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo
    J Immunol 174:1507-12. 2005
    ..Our study thus demonstrates that A20 is a candidate negative regulator of the signaling cascade to IRF-3 activation in the innate antiviral response...
  76. pmc IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer
    J Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Oncogene 32:151-9. 2013
    Serine/threonine kinase IKBKE is a newly identified oncogene; however, its regulation remains elusive...
  77. pmc Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteins
    Guerau Fernandez
    Center for Cancer and Immunology Research, Children s Research Institute, Children s National Medical Center, Washington, DC, USA
    J Virol 87:3966-78. 2013
    ..IκBε knockdown may offer attractive therapeutic advantages for HIV activation because it is not essential for mammalian growth and development and because new siRNA delivery strategies may target siRNAs to HIV latently infected cells...
  78. ncbi The interferon response to bacterial and viral infections
    Eric M Pietras
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 90095, USA
    J Endotoxin Res 12:246-50. 2006
    ..pathways converge on TRAF3, which induces interferon through the activation of IRF3 or IRF7 by the TBK-1 and IKKi complexes...
  79. pmc Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε
    Christelle Pythoud
    Institute of Microbiology University Hospital Center and University of Lausanne, Lausanne, Switzerland
    J Virol 86:7728-38. 2012
    ..LCMV NP bound the kinase domain (KD) of IKKε (IKBKE) and blocked its autocatalytic activity and its ability to phosphorylate IRF3, without undergoing phosphorylation...
  80. pmc IKK-ε coordinates invasion and metastasis of ovarian cancer
    Sarah Hsu
    Medical Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Res 72:5494-504. 2012
    ..Inhibition of IKK-ε signaling thus emerges as a viable therapeutic strategy in women whose ovarian cancer shows aberrant activation of this pathway...
  81. pmc MicroRNAs 296 and 298 are imprinted and part of the GNAS/Gnas cluster and miR-296 targets IKBKE and Tmed9
    Joan E Robson
    Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Centre, Oxfordshire, OX11 0RD, United Kingdom
    RNA 18:135-44. 2012
    ..Using microarrays and luciferase assays, IKBKE, involved in many signaling pathways, and Tmed9, a protein transporter, were verified as new targets of miR-296...
  82. doi A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide
    Qiong Luo
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    J Immunol 191:4969-78. 2013
    ..Iguratimod mainly targets Act1 to disrupt the interaction between Act1 and TRAF5 and IKKi in the IL-17 pathway of synoviocytes...
  83. pmc Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance
    Muhammet F Gulen
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Immunity 37:800-12. 2012
    ..Via biochemical and genetic approaches, the kinases IKKi and GSK3α were identified as the critical intermediate signaling components for IL-1-induced AKT activation, which ..
  84. pmc IKBKE phosphorylation and inhibition of FOXO3a: a mechanism of IKBKE oncogenic function
    Jian Ping Guo
    Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing, China
    PLoS ONE 8:e63636. 2013
    ..Here we report that IKBKE regulates FOXO3a through phosphorylation of FOXO3a-Ser644...
  85. pmc A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε
    Deguang Liang
    Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 225 South Chongqing Road, Shanghai 200025, China
    Cell Res 21:793-806. 2011
    ..Moreover, inhibition of miR-K12-11 enhanced KSHV reactivation induced by vesicular stomatitis virus infection. Taken together, our findings also suggest that miR-K12-11 can contribute to maintenance of KSHV latency by targeting IKKɛ...
  86. doi IKBKE is over-expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-κB
    Hongyu Guan
    Key Laboratory of Tropical Disease Control, Sun Yat Sen University, Ministry of Education, Guangzhou, Guangdong 510080, People s Republic of China
    J Pathol 223:436-45. 2011
    IκB kinase-ε (IKBKE), a member of the IκB kinase (IKK) family, has been identified as an oncogenic protein and found to be up-regulated in breast cancer, ovarian cancer and prostate cancer...
  87. ncbi IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    F Mercurio
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Science 278:860-6. 1997
    ..the IkappaB kinase (IKK) signalsome, was purified from HeLa cells and found to contain a cytokine-inducible IkappaB kinase activity that phosphorylates IkappaB-alpha and IkappaB-beta...
  88. doi Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change
    Kiyohiro Takahasi
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 12W 6 Kita ku, Sapporo 060 0812, Japan
    Genes Cells 15:901-10. 2010
    ..Thus, we conclude that the phosphorylation of Ser386 is essential for activation of IRF-3...
  89. pmc A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE
    Johanna K Sandling
    Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Eur J Hum Genet 19:479-84. 2011
    ..01 in the initial screen were then followed up in 344 additional Swedish patients and 1299 controls. SNPs in the IKBKE, TANK, STAT1, IL8 and TRAF6 genes gave nominal signals of association with SLE in this extended Swedish cohort...
  90. doi IκB Kinase ε expression in pancreatic ductal adenocarcinoma
    Anna Cheng
    Anatomic Pathology, Moffitt Cancer Center, Tampa, FL 33612, USA
    Am J Clin Pathol 136:60-6. 2011
    ..In addition, IKKε could serve as a prognostic marker and potential therapeutic target for PDA intervention...
  91. doi Alterations in the expression of genes related to NF-κB signaling in liver and kidney of CuZnSOD-deficient mice
    Kamil Brzoska
    Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03 195 Warsaw, Poland
    Mol Cell Biochem 353:151-7. 2011
    ..of liver, six genes were up-regulated, Fos, Il1b, Il1r1, Jun, Tlr7, Tnfrsf10b, and five down-regulated, Casp8, Ikbke, Irak1, Nfkb1, Raf1...
  92. ncbi Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes
    Wen Zhang
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
    Chin Med Sci J 25:1-12. 2010
    ..To investigate the role of TNF receptor-associated factor 2 (TRAF-2) and TRAF6 in CD40-induced nuclear factor-kappaB (NF-kappaB) signaling pathway and whether CD40 signaling requires TRAF2...
  93. pmc TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases
    Kislay Parvatiyar
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 285:14999-5009. 2010
    ..Activation of IRF3 requires C-terminal phosphorylation by the upstream kinases TBK1-IKKi, where IRF3 phosphorylation promotes dimerization, and subsequent nuclear translocation to the IFNbeta promoter...
  94. doi IκB-Kinase-ε (IKKε/IKKi/IκBKε) expression and localization in prostate cancer tissues
    Benjamin Péant
    Centre de Recherche du Centre Hospitalier de l Université de Montréal CR CHUM Institut du Cancer de Montréal, Quebec, Canada
    Prostate 71:1131-8. 2011
    ..A previous study reported significantly higher levels of Iκ-B kinase-epsilon (IKKε) expression in CR compared to androgen-responsive cell lines. In the present study, we evaluate IKKε expression in human prostate tissue...
  95. doi Effects of protein-energy malnutrition on NF-kappaB signalling in murine peritoneal macrophages
    Ricardo Ambrósio Fock
    Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, Sao Paulo University, 05508 900, Sao Paulo, SP, Brazil
    Inflammation 33:101-9. 2010
    ..PEM also decreased TRAF-6 expression and NF-kappaB activation after LPS stimulation. These results led us to conclude that PEM changes NF-kB signalling pathway in macrophages to LPS stimulus...
  96. ncbi NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation
    F Nomura
    Department of Host Defense, Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Genes Cells 5:191-202. 2000
    ..Unlike IKK-alpha and IKK-beta, IKK-i phosphorylated Ser36 but not Ser32 in vitro, suggesting that IKK-i activates NF-kappaB by distinct mechanisms from the conventional IKKs...
  97. ncbi A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    Ken J Ishii
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 7:40-8. 2006
    ..the promoter of the gene encoding interferon-beta through a signaling pathway that required the kinases TBK1 and IKKi, whereas there was substantial activation of transcription factor NF-kappaB independent of both TBK and IKKi...
  98. ncbi IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines
    Sabita Sankar
    Experimental Therapeutics Inflammation, Celgene, 4550 Towne Centre Court, San Diego, CA 92121, United States
    Cell Signal 18:982-93. 2006
    ..We also identified STAT1, Tyk2, and JAK1 as secondary mediators of IKK-i signaling as a result of interferon beta production in these cells...
  99. ncbi TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation
    Dae Ho Ahn
    Gastrointestinal Research Laboratory, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Cell Physiol Biochem 15:29-40. 2005
    ....
  100. pmc Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon
    Adrien Breiman
    Unité Hépacivirus, Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 79:3969-78. 2005
    ..The partial restoration of the capacity of the host cell to transcribe IFN-beta indicates that IKKepsilon expression is able to bypass the HCV-mediated inhibition and restore the innate antiviral response...
  101. ncbi Histamine H1 receptor antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, Raf/MEK/ERK and IKK/I kappa B/NF-kappa B signal cascades
    Masahiro Matsubara
    Department of Pharmacology and Molecular Biology, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co Ltd, Shizuoka 411 8731, Japan
    Biochem Pharmacol 69:433-49. 2005
    ..Thus, the anti-inflammatory benefit of H1 antagonists may be in part due to prevention of cytokine production...

Research Grants15

  1. Ras-Induced Lung Cancer: Key Roles for IKK and NF-kappaB
    ALBERT SIDNEY BALDWIN; Fiscal Year: 2013
    ..Additional new data indicate that variant forms of IKK, namely TBK1 and IKKe, nuclear in human lung tumor cells and that a dominant negative form of IKKe blocks NF-kB activation in these cells...
  2. Mechanisms by which the protein kinase IKKi regulates energy expenditure
    JONATHAN CARL MOWERS; Fiscal Year: 2012
    ..Our lab has recently shown that the IKK family member, IKKi (Ikbke), is an important mediator of systemic inflammation, insulin resistance, hepatic steatosis, body weight, and ..
  3. MEDIATORS AND MODIFIERS OF NF-kappaB IN INSULIN RESISTANCE
    Steven E Shoelson; Fiscal Year: 2010
    ..As the subject of this proposal we also see constitutive, NF-kappaB dependent expression of A20, IKKi/epsilon, and IkappaBzeta, in fat and liver of obese/HFD rodent models...
  4. Role of a novel IKK-related kinase in inflammation
    SUSAN ELAINE SWEENEY; Fiscal Year: 2010
    ..The IKK-related kinases, inducible IKK (IKKi) and TANK-binding kinase 1 (TBK1) were as originally identified as NF-kB activating kinases that phosphorylated IkB...
  5. Signaling Pathways in Stages of Tumorigenesis
    Gail E Sonenshein; Fiscal Year: 2012
    ..In particular, studies will focus on elucidating the roles of c-Rel, RelB, and IKKe/i kinase, and tumor inhibitory effects of green tea polyphenols...
  6. Regulation and function of IKKe in breast cancer initiation and maintenance
    William C Hahn; Fiscal Year: 2013
    ..In recent work, we have identified the inhibitor of ?B kinase 5 (IKBKE, IKKi IKK5) as amplified and overexpressed in a substantial subset of human breast cancer cell lines and tumors...
  7. The Function of IKKeplison in Breast Cancer
    RHINE SHEN; Fiscal Year: 2011
    ..structural characterization of cancer genomes to identify the novel breast oncogene, Inhibitor of KB kinase e (IKBKE, IKKe, IKKi)...
  8. The role of hepatic IKKi in regulating energy balance
    CHRISTINA LYNN SHERRY; Fiscal Year: 2010
    ..Recent studies from our laboratory indicate that expression and activity of the protein kinase IKKi is markedly up regulated in mice fed a high fat diet (HFD)...
  9. Modulation of the host response to influenza virus infection: The IKKe Kinase
    Benjamin R tenOever; Fiscal Year: 2013
    Modulation of the host response to influenza virus infection: The IKKe Kinase Project Summary Influenza viruses circulate in both avian and human hosts and account for annual outbreaks resulting in significant morbidity, mortality and ..
  10. Viral and Genetic Regulation of Abnormal OCL Activity in PD
    DEBORAH LYNN GALSON; Fiscal Year: 2012
    ..predominantly through increased NFicB signaling via activation of the two kB kinase (IKK)-related kinases IKKe (also called IKK-/) and TANK-binding kinase 1 (TBK1) and increased levels of RIP1 and TRAF2...
  11. IKBKE/IKKE (epsilon) Kinase in Non-small Cell Lung Cancer
    Jin Q Cheng; Fiscal Year: 2013
    ..We have detected upregulation and activation of IKBKE, a serine/threonine protein kinase, in a half of non-small cell lung cancers (NSCLC)...
  12. Probing the relevance of the "counter-inflammatory" noncanonical IkB kinases in r
    Alan R Saltiel; Fiscal Year: 2013
    ..We hypothesize that the noncanonical Ikb kinases IKKe and TBK1 are "counterinflammatory" kinases that keep inflammatory pathways in check while helping to support a ..
  13. Regulation of Type I Interferon Gene Expression in the Innate Immune Response
    Katherine A Fitzgerald; Fiscal Year: 2010
    ..TBK-1 and IKKE phosphorylate and activate IRF3. TBK1 and IKKe are required for TLR and RNA helicase signaling...
  14. IKKi expression and regulation in rheumatoid arthritis
    Gary Firestein; Fiscal Year: 2005
    ..mechanisms of chronic NF-kB activation, we propose to explore the function and regulation of a novel inducible IKK (IKKi)...