IHH

Summary

Gene Symbol: IHH
Description: indian hedgehog
Alias: BDA1, HHG2, indian hedgehog protein, Indian hedgehog homolog
Species: human

Top Publications

  1. pmc Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations
    Sarah Cormier
    Institut National de la Santé et de la Recherche Médicale U426, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    Am J Pathol 161:1325-35. 2002
  2. ncbi Cholesterol modification of hedgehog signaling proteins in animal development
    J A Porter
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Science 274:255-9. 1996
  3. ncbi Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
    P T Chuang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 397:617-21. 1999
  4. ncbi Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    David M Berman
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 425:846-51. 2003
  5. pmc Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage
    F Wei
    Department of Orthopedics, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Osteoarthritis Cartilage 20:755-63. 2012
  6. ncbi The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3
    M Bak
    Department of Medical Genetics, Institute of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Denmark
    Cytogenet Cell Genet 92:300-3. 2001
  7. pmc Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
    Nicolas de Roux
    Institut National de la Santé et de la Recherche Médicale Unité 135, Unité de Recherches Hormones Gènes et Reproduction, Hopital de Bicetre, 94275 Le Kremlin Bicetre, France
    Proc Natl Acad Sci U S A 100:10972-6. 2003
  8. ncbi Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback
    F J Hayes
    Department of Medicine and National Center for Infertility Research, Massachusetts General Hospital, Boston 02114, USA
    J Clin Endocrinol Metab 85:3027-35. 2000
  9. ncbi [The expression of basic fibroblast growth factor 1 during human embryonic yolk sac hematopoiesis]
    Yue Si Wang
    Department of Biotech, Binzhou Medical College, Yantai 264003, China
    Zhonghua Xue Ye Xue Za Zhi 29:535-9. 2008
  10. ncbi Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine, National Center for Infertility Research, General Clinical Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:4128-36. 2002

Research Grants

  1. Lawrence C Layman; Fiscal Year: 2014
  2. Transcriptional Regulation of Indian Hedgehog Expression in Chondrocytes
    Xiangli Yang; Fiscal Year: 2012
  3. JUAN MANUEL TABOAS; Fiscal Year: 2016
  4. ANDREW BRUCE LASSAR; Fiscal Year: 2014
  5. GENETICS OF DELAYED PUBERTY
    LAWRENCE LAYMAN; Fiscal Year: 2001
  6. ANA PAULA DE ABREU E SILVA METZGER; Fiscal Year: 2014
  7. ANDREW BRUCE LASSAR; Fiscal Year: 2016
  8. Maurizio Pacifici; Fiscal Year: 2015
  9. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2009
  10. Karen M Lyons; Fiscal Year: 2016

Detail Information

Publications250 found, 100 shown here

  1. pmc Parathyroid hormone receptor type 1/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations
    Sarah Cormier
    Institut National de la Santé et de la Recherche Médicale U426, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    Am J Pathol 161:1325-35. 2002
    The fibroblast growth factor receptor type 3 (FGFR3) and Indian hedgehog (IHH)/parathyroid hormone (PTH)/PTH-related peptide receptor type 1 (PTHR1) systems are both essential regulators of endochondral ossification...
  2. ncbi Cholesterol modification of hedgehog signaling proteins in animal development
    J A Porter
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Science 274:255-9. 1996
    ..This use of cholesterol to modify embryonic signaling proteins may account for some of the effects of perturbed cholesterol biosynthesis on animal development...
  3. ncbi Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
    P T Chuang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 397:617-21. 1999
    ..Overexpression of Hip in cartilage, where Indian hedgehog (Ihh) controls growth, leads to a shortened skeleton that resembles that seen when Ihh function is lost (B...
  4. ncbi Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    David M Berman
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 425:846-51. 2003
    ..Our results identify a group of common lethal malignancies in which Hh pathway activity, essential for tumour growth, is activated not by mutation but by ligand expression...
  5. pmc Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage
    F Wei
    Department of Orthopedics, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Osteoarthritis Cartilage 20:755-63. 2012
    The objectives of this study were to (1) determine the correlation between osteoarthritis (OA) and Indian hedgehog (Ihh) expression, and (2) establish the effects of Ihh on expression of markers of chondrocyte hypertrophy and matrix ..
  6. ncbi The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3
    M Bak
    Department of Medical Genetics, Institute of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Denmark
    Cytogenet Cell Genet 92:300-3. 2001
    ..HHIP comprises 13 exons and spans >91kb encoding a protein of 700 aa which shares 94% sequence iden- tity with mouse Hhip. HHIP maps to chromosome 4q31.21--> q31.3. Additionally, we have mapped murine Hhip to chromosome 8...
  7. pmc Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
    Nicolas de Roux
    Institut National de la Santé et de la Recherche Médicale Unité 135, Unité de Recherches Hormones Gènes et Reproduction, Hopital de Bicetre, 94275 Le Kremlin Bicetre, France
    Proc Natl Acad Sci U S A 100:10972-6. 2003
    ..Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH)...
  8. ncbi Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback
    F J Hayes
    Department of Medicine and National Center for Infertility Research, Massachusetts General Hospital, Boston 02114, USA
    J Clin Endocrinol Metab 85:3027-35. 2000
    ..Parallel studies of NL men and men with idiopathic hypogonadotropic hypogonadism (IHH), whose pituitary-gonadal axis had been normalized with long-term GnRH therapy, were performed to permit precise ..
  9. ncbi [The expression of basic fibroblast growth factor 1 during human embryonic yolk sac hematopoiesis]
    Yue Si Wang
    Department of Biotech, Binzhou Medical College, Yantai 264003, China
    Zhonghua Xue Ye Xue Za Zhi 29:535-9. 2008
    ..the expression of FGF1, vascular endothelial growth factor receptor (KDR), CD133, CD34 and transcription factors Ihh, SCL, GATA-1, GATA-2 and PU...
  10. ncbi Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine, National Center for Infertility Research, General Clinical Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:4128-36. 2002
    ..is successful in inducing virilization and spermatogenesis in men with idiopathic hypogonadotropic hypogonadism (IHH)...
  11. pmc A homozygous R262Q mutation in the gonadotropin-releasing hormone receptor presenting as constitutional delay of growth and puberty with subsequent borderline oligospermia
    Lin Lin
    Institute of Child Health and Department of Medicine, University College London, UK
    J Clin Endocrinol Metab 91:5117-21. 2006
    ..receptor plays a central role in regulating gonadotropin synthesis and release, and several mutations in the GNRHR gene have been reported in patients with idiopathic or familial forms of isolated hypogonadotropic hypogonadism (IHH).
  12. ncbi A mutation in the fibroblast growth factor receptor 1 gene causes fully penetrant normosmic isolated hypogonadotropic hypogonadism
    Ning Xu
    Section of Reproductive Endocrinology, Infertility, and Genetics, Department of Obstetrics and Gynecology, The Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912 3360, USA
    J Clin Endocrinol Metab 92:1155-8. 2007
    Kallmann syndrome (KS) consists of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia/hyposmia...
  13. ncbi Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways
    S J Karp
    Harvard University, Department of Molecular Biology, The Biolabs, Cambridge, MA 02138, USA
    Development 127:543-8. 2000
    Indian hedgehog (Ihh) and Parathyroid Hormone-related Protein (PTHrP) play a critical role in the morphogenesis of the vertebrate skeleton...
  14. ncbi [Relationship between TWIK-related acid-sensitive K+ channel-1 and TWIK-related acid-sensitive K+ channel-3 expression and the occurrence of central sleep apnea: experiment with rats]
    Cheng Zhang
    Department of Respiratory Diseases, First Hospital of Peking University, Beijing 100034, China
    Zhonghua Yi Xue Za Zhi 87:2929-31. 2007
    ..To investigate the role of the TWIK-related acid-sensitive K(+) channel-1 (TASK-1) in the occurrence of sleep apnea...
  15. doi [Kallmann syndrome. Fundamentals and two medical histories]
    J Hefner
    Abteilung Innere Medizin VI, Psychosomatische Medizin und Psychotherapie, Universitatsklinikum Tubingen, Otfried Muller Strasse 10, 72076, Tubingen, Deutschland
    Nervenarzt 80:1169-70, 1172-5. 2009
    Kallmann syndrome is defined as a combination of isolated hypogonadotropic hypogonadism (IHH), hyposmia or anosmia and several optional neurological or anatomical particularities...
  16. doi Baseline inhibin B and anti-Mullerian hormone measurements for diagnosis of hypogonadotropic hypogonadism (HH) in boys with delayed puberty
    Regis Coutant
    Department of Pediatric Endocrinology, Center for Rare Diseases in Hormonal Receptivity, Angers University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Clin Endocrinol Metab 95:5225-32. 2010
    The diagnosis of isolated hypogonadotropic hypogonadism (IHH) in boys with delayed puberty is challenging, as may be the diagnosis of hypogonadotropic hypogonadism (HH) in boys with combined pituitary hormone deficiency (CPHD)...
  17. ncbi A concomitant decrease in cortical and trabecular bone mass in isolated hypogonadotropic hypogonadism and gonadal dysgenesis
    K H Park
    Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea
    Yonsei Med J 40:444-9. 1999
    ..women, comprising 22 cases of gonadal dysgenesis and 48 cases of isolated hypogonadotropic hypogonadism (IHH)...
  18. doi Complex genetics in idiopathic hypogonadotropic hypogonadism
    Nelly Pitteloud
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Mass 02114, USA
    Front Horm Res 39:142-53. 2010
    Idiopathic hypogonadotropic hypogonadism (IHH) is an important human disease model. Investigations of the genetics of IHH have facilitated insights into critical pathways regulating sexual maturation and fertility...
  19. ncbi Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis
    M Iwasaki
    Department of Orthopaedic Surgery, University of California, San Francisco 94143 0514, USA
    Mech Dev 69:197-202. 1997
    ..1997. The world according to hedgehog. Trends Genet. 13, 14-21). Two potential targets of Ihh are bmp6 and gli (Johnson et al., 1995...
  20. ncbi Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism
    Fabio Lanfranco
    Institute of Reproductive Medicine of the University, D 48129 Munster, Germany
    Eur J Endocrinol 153:845-52. 2005
    To determine the frequency of mutations of the gonadotropin-releasing hormone receptor (GnRHR) and of the G protein-coupled receptor 54 (GPR54) genes in normosmic idiopathic hypogonadotropic hypogonadism (IHH).
  21. pmc Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
    R Serra
    Department of Cell Biology and the Vanderbilt Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Cell Biol 139:541-52. 1997
    ..Mice that express DNIIR in skeletal tissue also demonstrated increased Indian hedgehog (IHH) expression...
  22. doi Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy
    Kinglun Kingston Mak
    Genetic Disease Research Branch, National Human Genome Research Institute, 49 Convent Drive, MSC 4472, Bethesda, MD 20892, USA
    Development 135:1947-56. 2008
    ..Proper regulation of chondrocyte hypertrophy is also required in postnatal cartilage homeostasis. Indian hedgehog (Ihh) and PTHrP signaling play crucial roles in regulating the onset of chondrocyte hypertrophy by forming a negative ..
  23. ncbi Shh expression is required for embryonic hair follicle but not mammary gland development
    Kinga Michno
    Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada
    Dev Biol 264:153-65. 2003
    ..We demonstrate here that, unlike the hair follicle, both Shh and Ihh are expressed in the developing embryonic mouse mammary rudiment as early as E12.5...
  24. ncbi Expression profile of Xenopus banded hedgehog, a homolog of mouse Indian hedgehog, is related to the late development of endochondral ossification in Xenopus laevis
    Takeshi Moriishi
    Division of Oral Pathology and Bone Metabolism, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    Biochem Biophys Res Commun 328:867-73. 2005
    ..Since the Indian hedgehog (Ihh) is involved in endochondral ossification in mouse, we investigated the expression of Xenopus banded hedgehog (X-..
  25. ncbi PTHrP and skeletal development
    Henry M Kronenberg
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann N Y Acad Sci 1068:1-13. 2006
    ..Indian hedgehog (Ihh) is synthesized by chondrocytes that have just stopped proliferating and is required for synthesis of PTHrP...
  26. ncbi Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism
    Maria A Yialamas
    Reproductive Endocrine Unit of the Department of Medicine, Massachusetts General Hospital, Bartlett Hall Extension 511, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 92:4254-9. 2007
    ..Evidence suggests that testosterone (T) influences insulin sensitivity in men. The mechanism of this effect is unclear but is thought to involve changes in body composition...
  27. doi Trps1 deficiency enlarges the proliferative zone of growth plate cartilage by upregulation of Pthrp
    Katsuhiro Nishioka
    First Department of Pathology, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Bone 43:64-71. 2008
    ..Since expression of Trps1 protein was found to overlap with that of mRNAs for Indian hedgehog (Ihh), PTH/PTHrP receptor (PPR), and PTHrP, we hypothesized that Trps1 may inhibit the hypertrophic differentiation of ..
  28. pmc Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome
    Hyung Goo Kim
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Am J Hum Genet 83:511-9. 2008
    ..KS is a genetically heterogeneous disorder consisting of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia, and is most commonly due to KAL1 or FGFR1 mutations...
  29. ncbi Distribution of genes for parathyroid hormone (PTH)-related peptide, Indian hedgehog, PTH receptor and patched in the process of experimental spondylosis in mice
    Takanobu Nakase
    Department of Orthopaedic Surgery, Osaka University Medical School, Suita, Japan
    J Neurosurg 97:82-7. 2002
    ..determined the extent of genetic localization of major regulators of chondrogenesis such as Indian hedgehog (Ihh) and parathyroid hormone (PTH)-related peptide (PTHrP) and their receptors during the development of spondylosis in ..
  30. ncbi Voice changes after androgen therapy for hypogonadotrophic hypogonadism
    Timur Akcam
    Department of Otolaryngology Head and Neck Surgery, Gulhane Military Medical Academy, Ankara, Turkey
    Laryngoscope 114:1587-91. 2004
    Males with isolated hypogonadotropic hypogonadism (IHH) fail to undergo normal sexual development, including the lack of masculinization of the larynx...
  31. ncbi The genetics of hypogonadotropic hypogonadism
    Balasubramanian Bhagavath
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Semin Reprod Med 25:272-86. 2007
    An up-to-date review of the genetic aspects of idiopathic hypogonadotropic hypogonadism (IHH)/Kallmann syndrome (KS) is presented...
  32. pmc Indian hedgehog signaling pathway differences between swarm rat chondrosarcoma and native rat chondrocytes
    George S Oji
    Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    Iowa Orthop J 27:9-16. 2007
    Indian Hedgehog (Ihh)--Parathyroid related protein (PTHrP) and Fibroblast Growth Factor 3 (FGFR3) signaling pathways are important in regulating endochondral bone formation...
  33. ncbi Effects of different modes of intermittent hypobaric hypoxia on ischemia/reperfusion injury in developing rat hearts
    Hao Zhang
    Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China E mail
    Sheng Li Xue Bao 59:660-6. 2007
    The aim of the present study was to explore the effects of two different modes of intermittent hypobaric hypoxia (IHH) on myocardial ischemia/reperfusion injury in developing rat hearts...
  34. pmc Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling
    Eiki Koyama
    Department of Orthopaedic Surgery, Thomas Jefferson University, College of Medicine, Philadelphia, PA 19107, USA
    Ann N Y Acad Sci 1116:100-12. 2007
    Indian hedgehog (Ihh) has been previously found to regulate synovial joint formation...
  35. doi Kallmann syndrome caused by mutations in the PROK2 and PROKR2 genes: pathophysiology and genotype-phenotype correlations
    Julie Sarfati
    Université Paris Sud 11 et INSERM U693, Faculte de Medecine Paris Sud, Paris, France
    Front Horm Res 39:121-32. 2010
    ..olfaction and complete pubertal development, (2) congenital isolated (idiopathic) hypogonadotropic hypogonadism (IHH) but normal olfaction, (3) anosmia/hyposmia but normal pubertal development and gonadal function or (4) the two ..
  36. ncbi Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling
    Y Yang
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, MA 02138, USA
    Development 125:3123-32. 1998
    ..In contrast, a second Hh family member, Indian hedgehog (Ihh) which maps close to Dbf, is ectopically expressed in the distal limb bud...
  37. ncbi TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression
    Jesus Alvarez
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0576, USA
    Development 129:1913-24. 2002
    ..A signaling cascade involving Indian hedgehog (Ihh) and parathyroid hormone related peptide (PTHrP) has been described in which hypertrophic differentiation is ..
  38. ncbi Novel fibroblast growth factor receptor 1 mutations in patients with congenital hypogonadotropic hypogonadism with and without anosmia
    Ericka Barbosa Trarbach
    Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Disciplina de Endocrinologia e Metabologia, Av Dr Eneas de Carvalho Aguiar, 155 2o andar Bloco 6, 05403 900 Sao Paulo, Brazil
    J Clin Endocrinol Metab 91:4006-12. 2006
    ..To date, loss-of-function mutations in the genes encoding anosmin-1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1) have been described in the X-linked and autosomal dominant forms of this syndrome, respectively...
  39. ncbi Clinical assessment and molecular analysis of GnRHR and KAL1 genes in males with idiopathic hypogonadotrophic hypogonadism
    Beatriz R Versiani
    Division of Endocrinology, LIM 42 School of Medicine, University of Sao Paulo, SP, Brazil
    Clin Endocrinol (Oxf) 66:173-9. 2007
    The pathogenesis of idiopathic hypogonadotrophic hypogonadism (IHH) is mostly unclear. We characterized the clinical findings and molecular analysis of GnRHR and KAL1 genes in 26 Brazilian males with IHH with and without hyposmia/anosmia...
  40. ncbi Changes in serotoninergic receptors 1A and 2A in the piglet brainstem after intermittent hypercapnic hypoxia (IHH) and nicotine
    Meichien Say
    Department of Paediatrics and Child Health, University of Sydney, NSW 2006, Australia
    Brain Res 1152:17-26. 2007
    We studied the effects of intermittent hypercapnic hypoxia (IHH) and/or nicotine on the immunoreactivity of serotoninergic (5-HT) receptors 1A and 2A in the piglet brainstem...
  41. pmc Aberrant heparan sulfate proteoglycan localization, despite normal exostosin, in central chondrosarcoma
    Yvonne M Schrage
    Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Am J Pathol 174:979-88. 2009
    ..in heparan sulfate proteoglycan (HSPG) biosynthesis, which is important for signal transduction of Indian hedgehog (IHH), WNT, and transforming growth factor (TGF)-beta...
  42. doi Blood rheology adjustments in rats after a program of intermittent exposure to hypobaric hypoxia
    Santiago Esteva
    Departament de Fisiologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    High Alt Med Biol 10:275-81. 2009
    Intermittent hypobaric hypoxia (IHH) exposure induces a rise in hemoglobin concentration and an increase in erythrocyte mass in both rats and humans...
  43. pmc Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism
    Taneli Raivio
    Reproductive Endocrine Unit, Department of Medicine, The Harvard Center for Reproductive Endocrine Sciences, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:4380-90. 2009
    FGFR1 mutations have been identified in about 10% of patients with Kallmann syndrome. Recently cases of idiopathic hypogonadotropic hypogonadism (IHH) with a normal sense of smell (nIHH) have been reported.
  44. pmc Mutations of the KISS1 gene in disorders of puberty
    L G Silveira
    Unidade de Endocrinologia do Desenvolvimento, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP 05403 900, Brasil
    J Clin Endocrinol Metab 95:2276-80. 2010
    ..Inactivating mutations of its receptor (KISS1R) cause isolated hypogonadotropic hypogonadism (IHH). A unique KISS1R-activating mutation was described in central precocious puberty (CPP).
  45. doi Oxidative stress in rat testis and epididymis under intermittent hypobaric hypoxia: protective role of ascorbate supplementation
    Jorge Gonzalo Farias
    Instituto de Biotecnología de Tarapacá, Universidad Arturo Prat, Av Arturo Prat 2120, Iquique, Chile
    J Androl 31:314-21. 2010
    ..The present study was conducted to evaluate the effects of intermittent HH (IHH; equivalent to 4600 m above mean sea level) on oxidative stress and the protective role of dietary ascorbic acid on ..
  46. ncbi [Diabetic nephropathy and isolated hyporeninemic hypoaldosteronism]
    J Hrnciar
    Interná klinika a nemocnice F D Roosevelta, Banska Bystrica
    Vnitr Lek 42:394-9. 1996
    ..In 18.3% no response was observed (decompensated form of IHH). Diabetic hypertonics behaved like control hypertonics on long-term beta-blocker treatment...
  47. ncbi Hedgehog signaling regulation of insulin production by pancreatic beta-cells
    M K Thomas
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston 02114, USA
    Diabetes 49:2039-47. 2000
    ..Mammalian Hhs include Sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (Dhh)...
  48. ncbi Gene expression profile of bovine bone marrow mesenchymal stem cell during spontaneous chondrogenic differentiation in pellet culture system
    Darko Bosnakovski
    Laboratory of Veterinary Surgery, Department of Clinical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 53:127-39. 2006
    ..protein 6 (BMP 6), insulin-like growth factors 1, parathyroid hormone related peptide and indian hedgehog (Ihh) were detected...
  49. ncbi Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage
    Katsuaki Kanbe
    Department of Orthopaedic Surgery, Tokyo Women s Medical University, Medical Center East, 2 1 10 Nishiogu, Arakawa ku, Tokyo, 116 8567, Japan
    Mod Rheumatol 16:131-6. 2006
    ..three mechanoresponsive genes: cartilage matrix protein (CMP, matrilin-1), type X collagen, and Indian hedgehog (Ihh). In fact, all of the genes identified in these chondrocytes are associated solely with mechanical stress...
  50. doi Experience with hemihyperplasia and Beckwith-Wiedemann syndrome surveillance protocol
    Yuri A Zarate
    Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Am J Med Genet A 149:1691-7. 2009
    Beckwith-Wiedemann syndrome (BWS) and isolated hemihyperplasia (IHH) are two well known overgrowth conditions that are associated with cancer predisposition...
  51. pmc Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse
    Heather L Franco
    Department of Molecular and Cellular Biology, Department of Molecular and Human Genetics, The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 82:991-9. 2010
    Previous work has identified Indian hedgehog (Ihh) as a major mediator of progesterone signaling during embryo implantation. Ihh acts through its downstream effector smoothened (Smo) to activate the GLI family of transcription factors...
  52. doi Genetics basis for GnRH-dependent pubertal disorders in humans
    Leticia Ferreira Gontijo Silveira
    Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42 da Disciplina de Endocrinologia do Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
    Mol Cell Endocrinol 324:30-8. 2010
    ..Mutations in GNRH1, KISS1R and GNRHR genes cause normosmic IHH, interfering with the normal synthesis, secretion or action of GnRH...
  53. ncbi Effects of gonadotropin and testosterone treatments on plasma leptin levels in male patients with idiopathic hypogonadotropic hypogonadism and Klinefelter's syndrome
    M Ozata
    Department of Endocrinology, Gulhane School of Medicine Etik, Ankara, Turkey
    Horm Metab Res 30:266-71. 1998
    ..leptin levels before and 3 months after treatment in 21 patients with idiopathic hypogonadotropic hypogonadism (IHH), 16 patients with Klinefelter's syndrome and 20 male controls...
  54. ncbi Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism
    T Ogura
    Health and Medical Center, Okayama University, Japan
    J Endocrinol Invest 23:246-50. 2000
    ..4 kg/m2) with idiopathic hypothalamic hypogonadism (IHH). We also measured the BMI and serum concentrations of L in 99 age-matched healthy subjects...
  55. ncbi Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma
    J V Bovée
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Lab Invest 80:1925-34. 2000
    ..diffusion leads to the hypothesis that EXT inactivation affects fibroblast growth factor (FGF) and Indian Hedgehog (IHh)/parathyroid hormone-related peptide (PTHrP) signaling, two important pathways in chondrocyte proliferation and ..
  56. ncbi The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor
    N Pitteloud
    Reproductive Endocrine Unit of the Department of Medicine and National Center for Infertility Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:2470-5. 2001
    Mutations in the GnRH receptor (GnRH-R) gene have been reported to cause idiopathic hypogonadotropic hypogonadism (IHH)...
  57. ncbi Immunohistochemical detection of parathyroid hormone-related peptide, Indian hedgehog, and patched in the process of endochondral ossification in the human
    T Nakase
    Department of Orthopaedic Surgery E3, Osaka University Medical School, 2 2, Yamadaoka, Suita 565 0871, Japan
    Histochem Cell Biol 116:277-84. 2001
    Parathyroid hormone-related peptide (PTHrP), Indian hedgehog (Ihh), and patched (Ptc; a receptor for Ihh) were immunolocalized in tissue undergoing endochondral ossification in the human...
  58. ncbi Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA
    Ron A Deckelbaum
    Department of Medicine and Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, QC, Canada H3T 1E2
    J Cell Sci 115:3015-25. 2002
    Indian Hedgehog (Ihh), a member of the hedgehog (HH) family of secreted morphogens, and parathyroid hormone-related peptide (PTHrP) are key regulators of cartilage cell (chondrocyte) differentiation...
  59. ncbi Effect of x-irradiation on growth and the expression of parathyroid hormone-related peptide and Indian hedgehog in the tibial growth plate of the rat
    B Bakker
    Department of Paediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 59:35-41. 2003
    To study the effect of irradiation on the longitudinal growth and the expression of parathyroid hormone-related peptide (PTHrP) and Indian hedgehog (IHh) in tibial growth plates of rats.
  60. ncbi Effect of stimulus cycle time on acute respiratory responses to intermittent hypercapnic hypoxia in unsedated piglets
    Karen A Waters
    Department of Medicine, The University of Sydney, Sydney, New South Wales 2006, Australia
    J Appl Physiol (1985) 94:2465-74. 2003
    ..Despite this, piglets in these intermediate intermittent HH (IHH) groups (8- and 4-min cycles) showed more severe acidosis and attenuated temperature changes (P < 0...
  61. ncbi Gonadotropin treatment increases homocysteine levels in idiopathic hypogonadotropic hypogonadism: an indirect effect mediated by changes in body composition
    C Oktenli
    Department of Internal Medicine, Gulhane Military Medical Academy, TR 06018 Etlik Ankara, Turkey
    J Endocrinol 179:35-9. 2003
    ..state and after gonadotropin treatment for 6 Months in patients with idiopathic hypogonadotropic hypogonadism (IHH). Thirty-five newly diagnosed male patients with IHH (mean age 21.34+/-1...
  62. ncbi Ontogeny of GnRH and olfactory neuronal systems in man: novel insights from the investigation of inherited forms of Kallmann's syndrome
    David González-Martínez
    Department of Medicine, Neuroendocrinology Unit, Upper Third Floor, Royal Free and University College Medical School, University College of London, NW3 2PF, London, UK
    Front Neuroendocrinol 25:108-30. 2004
    ..neuronal ontogeny can be caused by several monogenic disorders leading to isolated hypogonadotrophic hypogonadism (IHH); these include mutations within KAL-1, GnRH-R, and FGFR1...
  63. ncbi Epithelial hedgehog signals pattern the intestinal crypt-villus axis
    Blair B Madison
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0616, USA
    Development 132:279-89. 2005
    ..Sonic (Shh) and Indian (Ihh) hedgehog are expressed in the epithelium throughout these morphogenic events, and mice lacking either factor ..
  64. ncbi Identification and characterization of DISP3 gene in silico
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 26:551-6. 2005
    Lipid-modified soluble proteins Hedgehog (SHH, DHH and IHH) and WNT (WNT1, WNT2, WNT2B, WNT3, etc...
  65. ncbi Localization of Indian hedgehog and PTH/PTHrP receptor expression in relation to chondrocyte proliferation during mouse bone development
    Helen E MacLean
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Dev Growth Differ 47:59-63. 2005
    ..Using this system, we examined the expression of Indian hedgehog (Ihh) and PTH/PTHrP receptor (PPR) mRNA in relation to chondrocyte proliferation during embryonic mouse bone development...
  66. ncbi The prevalence of gonadotropin-releasing hormone receptor mutations in a large cohort of patients with hypogonadotropic hypogonadism
    Balasubramanian Bhagavath
    Division of Reproductive Endocrinology, Infertility, and Genetics, Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta, Georgia, USA
    Fertil Steril 84:951-7. 2005
    To determine the prevalence of GNRH receptor (GNRHR) gene mutations in a large cohort of patients with idiopathic hypogonadotropic hypogonadism (IHH).
  67. ncbi Functional compensation in Hedgehog signaling during mouse prostate development
    Jason Doles
    Department of Surgery, University of Wisconsin Madison, Box 3236 Clinical Science Center G5, 600 Highland Avenue, Madison, WI 53792, USA
    Dev Biol 295:13-25. 2006
    ..These studies showed that genetic loss of Shh is accompanied by an up-regulation of Indian Hedgehog (Ihh) and maintenance of Hh pathway activity...
  68. ncbi Intraflagellar transport is essential for endochondral bone formation
    Courtney J Haycraft
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Development 134:307-16. 2007
    ..associated with aberrant Shh pathway activity, whereas defects in limb outgrowth were due in part to disruption of Ihh signaling during endochondral bone formation...
  69. ncbi The hedgehog signaling pathway in the mouse ovary
    Matthew C Russell
    Department of Animal Science, Cornell University, Ithaca, New York 14853, USA
    Biol Reprod 77:226-36. 2007
    ..RT-PCR analyses show developmentally regulated expression of sonic (Shh), indian (Ihh) and desert (Dhh) HH in the ovary. Expression is detected in whole ovary, granulosa cells, and corpora lutea...
  70. pmc Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton
    Ling Yu
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70117, USA
    Dev Biol 306:549-59. 2007
    ..of Runx2 and Runx3 could account for the lack of chondrocyte hypertrophy, while a down-regulation of Ihh expression may be responsible for a significant reduction in chondrocyte proliferation in the mutant stylopod...
  71. ncbi Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Stem Cell Rev 3:30-8. 2007
    ..BMP signals induce IHH upregulation in co-operation with RUNX...
  72. ncbi Hedgehog signaling in development and homeostasis of the gastrointestinal tract
    Gijs R van den Brink
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Physiol Rev 87:1343-75. 2007
    ..Three mammalian hedgehog genes, sonic hedgehog (Shh), indian hedgehog (Ihh), and desert hedgehog (Dhh) have been identified...
  73. pmc Hepatitis C virus genotype 1a growth and induction of autophagy
    Malika Ait-Goughoulte
    Division of Infectious Diseases and Immunology, Center for Vaccine Development, Edward A Doisy Research Center, 1100 S Grand Blvd, 8th Floor, St Louis, MO 63104, USA
    J Virol 82:2241-9. 2008
    We have previously reported that immortalized human hepatocytes (IHH) support the generation of infectious hepatitis C virus (HCV) genotype 1a (clone H77)...
  74. ncbi Adult-onset idiopathic hypogonadotropic hypogonadism and pregnancy in a 35-year-old woman: a case report
    Robert P Kauffman
    Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center at Amarillo School of Medicine, Amarillo, USA
    J Reprod Med 53:132-4. 2008
    Idiopathic hypogonadotropic hypogonadism (IHH) is a rare condition characterized by low gonadotropin production, absent or incomplete puberty and absence of a central nervous system tumor...
  75. pmc Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa
    Hanna Haveri
    Children s Hospital, University of Helsinki, Helsinki, Finland
    BMC Gastroenterol 8:9. 2008
    ..in detail the expression patterns of these two GATA factors and a GATA-6 down-stream target, Indian hedgehog (Ihh), in normal human gastrointestinal mucosa...
  76. doi Co-conjugating chondroitin-6-sulfate/dermatan sulfate to chitosan scaffold alters chondrocyte gene expression and signaling profiles
    Yen Lin Chen
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan
    Biotechnol Bioeng 101:821-30. 2008
    ..pathways (as unveiled by cDNA microarray) and upregulated the expression of TGF-beta1, Sox9, BMP2, PTHrP and Ihh (as confirmed by qRT-PCR)...
  77. ncbi Expression of hedgehog family genes in the rat uterus during early pregnancy
    Kaiyu Kubota
    Department of Animal and Marine Bioresource Sciences, Graduate School of Agriculture, Kyushu University, Fukuoka, Japan
    J Reprod Dev 54:340-5. 2008
    ..In mammals, Hh exists in three homologs: Desert hedgehog (Dhh), Indian hedgehog (Ihh) and Sonic hedgehog (Shh). In this study, we cloned full-length cDNAs encoding Dhh and Ihh from the rat uterus...
  78. doi Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation
    Susan V Outram
    Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
    Blood 113:2217-28. 2009
    We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number...
  79. ncbi Prediction of testosterone response to human chorionic gonadotrophin in idiopathic hypogonadotropic hypogonadism patients
    Mahmut Yazici
    Department of Endocrinology, Gulhane School of Medicine, Etlik, Ankara, Turkey
    J Natl Med Assoc 101:71-6. 2009
    ..inhibin B levels are able to predict testosterone response to hCG in idiopathic hypogonadotropic hypogonadism (IHH) patients and to evaluate the correlation between inhibin B and gonadotropins in these patients and controls...
  80. doi Morphology and physiology of the epiphyseal growth plate
    Franciszek Burdan
    Experimental Teratology Unit of the Human Anatomy Department, Medical University of Lublin, Lublin, Poland
    Folia Histochem Cytobiol 47:5-16. 2009
    ..When proliferation is completed, chondrocytes release Indian hedgehog (Ihh), which stimulates PTHrP synthesis via a feedback loop...
  81. doi Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine
    Willemijn A van Dop
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 139:1665-76, 1676.e1-10. 2010
    Indian Hedgehog (Ihh) is expressed by the differentiated epithelial cells of the small intestine and signals to the mesenchyme where it induces unidentified factors that negatively regulate intestinal epithelial precursor cell fate...
  82. pmc Endoglin is a novel endothelial cell specification gene
    Saswati Banerjee
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Stem Cell Res 8:85-96. 2012
    ..The Eng-induced EC differentiation was independent of known mediators of EC specification such as Indian Hedgehog (IHH) and BMP4 or of BMP4/Smad1/5/8 signaling. These studies suggest that Eng is a novel EC specification gene.
  83. ncbi [Clinical and molecular aspects of congenital isolated hypogonadotropic hypogonadism]
    Cintia Tusset
    Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular, Divisão de Endocrinologia e Metabologia, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Basil
    Arq Bras Endocrinol Metabol 55:501-11. 2011
    Congenital isolated hypogonadotropic hypogonadism (IHH) is characterized by partial or complete lack of pubertal development due to defects in migration, synthesis, secretion or action of gonadotropin-releasing hormone (GnRH)...
  84. pmc A large duplication involving the IHH locus mimics acrocallosal syndrome
    Memnune Yuksel-Apak
    Department of Medical Genetics, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
    Eur J Hum Genet 20:639-44. 2012
    Indian hedgehog (Ihh) signaling is a major determinant of various processes during embryonic development and has a pivotal role in embryonic skeletal development...
  85. doi Estrogen receptor α and hedgehog signal pathway developmental biology of gastric adenocarcinoma
    Chaoyang Xu
    Department of Breast and Thyroid Surgery, Shaoxing People s Hospital, Shaoxing, China
    Hepatogastroenterology 59:1319-22. 2012
    ..Hedgehog family which includes Sonic (Shh), Indian (Ihh) and Desert (Dhh) hedgehogs, is involved in the vast majority of cellular processes and is fundamentally important ..
  86. pmc Muenke syndrome mutation, FgfR3P²⁴⁴R, causes TMJ defects
    T Yasuda
    Division of Orthopaedic Surgery, The Children s Hospital of Philadelphia, Abramson Research Center, 3516 Civic Center Blvd, Philadelphia, PA 19107, USA
    J Dent Res 91:683-9. 2012
    ..was expressed in condylar chondroprogenitors and maturing chondrocytes that also expressed the Indian hedgehog (Ihh) receptor and transcriptional target Patched 1(Ptch1)...
  87. pmc Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model
    Eun Jung Kim
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea 21 Project, Oral Science Research Center, College of Dentistry, Yonsei University, Seoul, Korea
    PLoS ONE 8:e55296. 2013
    ..Indian hedgehog (Ihh), one of the hedgehog signaling molecules, is known to control both the hypertrophy of chondrocytes and bone ..
  88. pmc Targeted disruption of Shp2 in chondrocytes leads to metachondromatosis with multiple cartilaginous protrusions
    Harry K W Kim
    Texas Scottish Rite Hospital for Children, Dallas, TX, USA Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Bone Miner Res 29:761-9. 2014
    ..At molecular levels, we observed an abundant expression of Indian hedgehog protein (IHH) and fibroblast growth factor 2 (FGF2) and impaired expression of mitogen-activated protein kinases (..
  89. pmc A GDF5 point mutation strikes twice--causing BDA1 and SYNS2
    Elisa Degenkolbe
    Berlin Brandenburg Center for Regenerative Therapies BCRT, Charite Universitatsmedizin Berlin, Berlin, Germany Berlin Brandenburg School for Regenerative Therapies BSRT, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS Genet 9:e1003846. 2013
    ..report on a family with an autosomal dominant inherited combination of SYNS2 and additional brachydactyly type A1 (BDA1) caused by a single point mutation in GDF5 (p.W414R)...
  90. doi [Identification of osteogenic signal and the development of artificial bones]
    Shinsuke Ohba
    Department of Bioengineering, The University of Tokyo Graduate School of Engineering, Japan
    Clin Calcium 23:1723-9. 2013
    ..During the endochondral ossification, indian hedgehog (Ihh) /parathyroid hormone-related protein (PTHrP) negative-feedback loop regulates the distance between epiphysis and ..
  91. doi Modulation of cardiac mitochondrial permeability transition and apoptotic signaling by endurance training and intermittent hypobaric hypoxia
    J Magalhaes
    Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Portugal Electronic address
    Int J Cardiol 173:40-5. 2014
    ..are critically associated with the cardioprotective phenotypes afforded by both intermittent hypobaric-hypoxia (IHH) and endurance-training (ET)...
  92. doi Critical hepatic hemangioma in infants: recent nationwide survey in Japan
    Tatsuo Kuroda
    Infantile Hepatic Hemangioma Study Group, Department of Pediatric Surgery, Keio University, School of Medicine, National Center for Child Health and Development, Tokyo, Japan
    Pediatr Int 56:304-8. 2014
    ..little has been established regarding vascular lesions in deep organs, such as infantile hepatic hemangioma (IHH). The current nationwide survey identified 19 critical infantile hemangiomas during the most recent 5 years...
  93. doi Tissue-specific Gene Expression in Rat Hearts and Aortas in a Model of Vascular Nitrate Tolerance
    Tamas Csont
    Department of Biochemistry, University of Szeged, Szeged, Hungary Pharmahungary Group, Szeged, Hungary Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary and Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    J Cardiovasc Pharmacol 65:485-93. 2015
    ..the heart (increased: Tas2r119, Map6, Cd59, Kcnh2, Kcnh3, Senp6, Mcpt1, Tshb, Haus1, Vipr1, Lrn3, Lifr; decreased: Ihh, Fgfr1, Cryge, Krt9, Agrn, C4bpb, Fcer1a, Csf3, Hsd17b11, Hsd11b2, Ctnnbl1, Prpg1, Hsf1), only 14 genes were ..
  94. doi Anti-TNFα treatment decreases the previously increased serum Indian Hedgehog levels in patients with ankylosing spondylitis and affects the expression of functional Hedgehog pathway target genes
    Dimitrios Daoussis
    Department of Rheumatology, University of Patras Medical School, Patras University Hospital, Rion 26504, Patras, Greece Electronic address
    Semin Arthritis Rheum 44:646-51. 2015
    Indian Hedgehog (Ihh) is the ligand that activates the Hedgehog pathway (HH) in the skeleton-the main controller of endochondral ossification...
  95. doi The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients
    Miao He
    Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China
    Clin Sci (Lond) 129:809-22. 2015
    ....
  96. pmc Differential effects of tyrosine-rich amelogenin peptide on chondrogenic and osteogenic differentiation of adult chondrocytes
    H D Amin
    Department of Bioengineering, Imperial College London, London, UK
    Cell Tissue Res 364:219-24. 2016
    ..for Ca(+2)-rich bone nodules; (3) OC immunostaining; and (4) expression of the osteogenic/hypertrophic genes Ihh and BSP...
  97. doi Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes
    Bing M Liao
    Diabetes and Metabolism Division B M L, S A M, W E H, C S P, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia and St Vincent s Hospital Clinical School W E H, C S P, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2052, Australia
    Mol Endocrinol 30:417-28. 2016
    ..HepG2 and IHH hepatocytes were transfected with FMO3 cDNA for overexpression, or small interfering RNA for knockdown...
  98. doi Pharmacological rescue of diabetic skeletal stem cell niches
    Ruth Tevlin
    Hagey Laboratory for Pediatric Regenerative Medicine and Department of Surgery, Stanford University, Palo Alto, CA 94305, USA
    Sci Transl Med 9:. 2017
    ..that high serum concentrations of tumor necrosis factor-α directly repressed the expression of Indian hedgehog (Ihh) in mSSCs and in their downstream skeletogenic progenitors in Db mice...
  99. ncbi The nature of the gonadotropin-releasing hormone stimulus-luteinizing hormone secretory response of human gonadotrophs in vivo
    J D Veldhuis
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville 22908
    J Clin Endocrinol Metab 68:661-70. 1989
    ..analyze (1) exogenous GnRH-stimulated LH secretory responses in 10 men with isolated hypogonadotropic hypogonadism (IHH), and (2) endogenous and exogenous GnRH-stimulated LH secretory responses in 8 normal men...
  100. ncbi Does adult fracture repair recapitulate embryonic skeletal formation?
    C Ferguson
    Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Ave, San Francisco, USA
    Mech Dev 87:57-66. 1999
    ..They included genes in the indian hedgehog (ihh) and core binding factor 1 (cbfa1) pathways, and genes associated with extracellular matrix remodeling and vascular ..
  101. ncbi The importance of autosomal genes in Kallmann syndrome: genotype-phenotype correlations and neuroendocrine characteristics
    L M Oliveira
    Reproductive Endocrine Sciences Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:1532-8. 2001
    Kallmann syndrome (KS) consists of congenital, isolated, idiopathic hypogonadotropic hypogonadism (IHH) and anosmia...

Research Grants64

  1. Lawrence C Layman; Fiscal Year: 2014
    ..Idiopathic hypogonadotropic hypogonadism (IHH) represents a naturally occurring human model of impaired GnRH action which provides insight into hypothalamic-..
  2. Transcriptional Regulation of Indian Hedgehog Expression in Chondrocytes
    Xiangli Yang; Fiscal Year: 2012
    ..is directed at improving understanding of the transcriptional control of the Hedgehog pathway, and specifically of Ihh, during chondrogenesis and how it may be linked to osteogenesis...
  3. JUAN MANUEL TABOAS; Fiscal Year: 2016
    ..The growth factors parathyroid hormone related peptide (PTHrP) and indian hedgehog (IHH) are major effectors of GP development via a negative feedback gradient loop...
  4. ANDREW BRUCE LASSAR; Fiscal Year: 2014
    ..e., Ihh and Collagen X) only if these cells are first induced to become chondrocytes by a variety of treatments, suggesting ..
  5. GENETICS OF DELAYED PUBERTY
    LAWRENCE LAYMAN; Fiscal Year: 2001
    DESCRIPTION (Adapted from the Investigator's Abstract): Idiopathic hypogonadotropic hypogonadism (IHH) is due to a deficiency of GnRH. The major goal of this proposal is to isolate the gene(s) important in the genesis of IHH...
  6. ANA PAULA DE ABREU E SILVA METZGER; Fiscal Year: 2014
    ..My first aim is to define the role of the PROKR2 heterozygous mutations in isolated hypogonadotropic hypogonadism (IHH), testing the hypothesis that heterozygous mutations in PROKR2 in patients with GnRH deficiency are not sufficient ..
  7. ANDREW BRUCE LASSAR; Fiscal Year: 2016
    ..PTHrP expression is itself dependent upon Ihh expression in prehypertrophic chondrocytes in the growth plate...
  8. Maurizio Pacifici; Fiscal Year: 2015
    ..In ongoing studies, we found that HS deficiency in growth plate leads to re-distribution of Indian hedgehog (Ihh), its infiltration over the entire perichondrium and formation of exostosis-like cartilaginous masses within ..
  9. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2009
    ..These mice may represent an ideal model for Kallmann Syndrome (KS) or Idiopathic Hypogonadotropic Hypogonadism (IHH)...
  10. Karen M Lyons; Fiscal Year: 2016
    ..1, we investigate how Smad1/5-dependent, Smad4-independent mechanisms transcriptionally regulate the expression of Ihh, a key direct target of BMP pathways in chondrocytes...
  11. The role of FGF signaling in neuroendocrine control of reproduction
    Nelly Pitteloud; Fiscal Year: 2012
    ..critical for GnRH ontology 2) Perform genotype-phenotype correlations for mutations in the FGF pathways causing IHH, and 3) Study mutant FGF protein using crystallography and molecular and cell biology techniques...
  12. Role of Trps1 in endochondral bone formation
    Dobrawa Napierala; Fiscal Year: 2011
    ..These abnormalities are accompanied by increased Indian hedgehog (Ihh) expression and elevated Ihh and BMP signaling...
  13. GFP Reporters for the chondrocyte lineage
    David Rowe; Fiscal Year: 2009
    ..condensation), Sox9 and Col1a1;proliferating chondrocytes, Sox9 and Col2a1;prehypertrophic chondrocytes, IHH;hypertrophic chondrocytes, Col10a1...
  14. BC12 AND PTHRP REGULATED CHONDROCYTE MATURATION
    Roland Baron; Fiscal Year: 2001
    ..Bcl-2 is transcriptional or not; and (3) determine whether other molecules known to affect chondrocyte maturation (Ihh, the FGFs, and the BMPs) affect Bcl-2 expression and whether they intervene between PTHrP and Bcl-2 on the same ..
  15. TESTOSTERONE EFFECTS ON GONADOTROPINS AND LIPIDS IN MEN
    CARRIE BAGATELL; Fiscal Year: 1992
    ..We will study men with idiopathic hypothalamic hypogonadism (IHH) who receive pulsatile GnRH infusions...
  16. Clifford J Tabin; Fiscal Year: 2015
    ..PTHrP works in a feedback loop with a second secreted protein;Indian hedgehog (Ihh)...
  17. Cyclooxygenases in Skeletal Repair
    Xinping Zhang; Fiscal Year: 2013
    ..In addition, we will also define the signaling mechanisms downstream of COX-2 by which Indian Hedgehog (Ihh) is induced by COX-2/PGE2 via activation of ATF4 phosphorylation...
  18. Shuying Yang; Fiscal Year: 2014
    ..the expression of osteoblast marker genes- Runx2 and osteocalcin, and hedgehog signaling (Hh) related genes -shh, Ihh and Gli2...
  19. Neuronal Specification and Developmental Regulation of GnRH Gene Expression.
    Anita Iyer; Fiscal Year: 2009
    ..for proper reproductive function as dysregulation of GnRH leads to idiopathic hypogonadotropic hypogonadism (IHH), Kallmann's Syndrome, and infertility...
  20. Matthew J Hilton; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Signaling pathway components such as Ihh/Pthrp, TGF[unreadable], BMPs, Wnt/[unreadable]-catenin, FGFs, and Sox-related proteins represent important regulators of cartilage formation and development...
  21. The role of pRb-dependent Ihh in osteogenesis and osteosarcoma
    CRYSTAL BRYAN; Fiscal Year: 2013
    ..The lab also found more recently that Indian hedgehog (Ihh) is downregulated in Rb1-/- calvarial cells during differentiation, implicating this factor as a potential mediator ..
  22. T Rajendra Kumar; Fiscal Year: 2016
    ..Our central hypothesis is that both estrogen receptor-1 (ESR1) and Indian hedgehog (IHH) contribute to growth of pituitary gonadotrope adenomas and inhibiting their expression leads to clinical benefit...
  23. Nancy B Schwartz; Fiscal Year: 2014
    ..broad goal of this proposal is to understand the influence of matrix chondroitin sulfate proteoglycans (CSPGs) on IHH and FGF signaling in the developing limb growth plate...
  24. ENDOCHONDRAL BONE FORMATION IN RENAL FAILURE
    ISIDRO SALUSKY; Fiscal Year: 1999
    ..the critical roles of parathyroid hormone related protein (PTHrP), PTH/PTHrP receptor, and the Indian hedgehog (Ihh) in the regulation of endochondral bone formation; PTH/PTHrP receptor mRNA expression is downregulated in bone and ..
  25. A high-throughput screen for small-molecule antagonists of Gli function
    James K Chen; Fiscal Year: 2012
    ..that regulate Hh target gene expression, which in mammals include the Sonic, Indian, and Desert Hh ligands (Shh, Ihh, and Dhh), the Hh receptor Patched1 (Ptch1), the transmembrane protein Smoothened (Smo), the Gli family of ..
  26. John P Lydon; Fiscal Year: 2016
    ..During the last funding period, we have demonstrated that conditional ablation of Ihh in the murine uterus results in loss of stroma cell proliferation, vascularization, and differentiation...
  27. Role of Indian hedgehog in Endochondral Bone Formation
    Beate Lanske; Fiscal Year: 2009
    Indian hedgehog (Ihh) has multiple functions during skeletogenesis...
  28. NATALIA ANDREA RIOBO-DEL GALDO; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The Hedgehog (Hh) ligands (Shh, Ihh, and Dhh) signal through two membrane receptors (Ptc1 and Ptc2), the regulatory membrane protein Smoothened (SMO), and the Gli transcription factors...
  29. FUNCTIONS OF PTH/PTHRP RECEPTOR--PTHRP AND PTH IN VIVO
    Henry Kronenberg; Fiscal Year: 1999
    ..This signaling system interacts with other signaling systems-including those triggered by Indian hedgehog (Ihh), bone morphogenic proteins (BMPs), and cytokines that activate gpl30-to assure normal growth and calcium ..
  30. Indian Hedgehog Signaling in Osteoblast Differentiation
    Fanxin Long; Fiscal Year: 2013
    ..Work from our laboratory and others has firmly established Indian hedgehog (Ihh), a member of the Hedgehog (Hh) family, as an essential regulator for osteoblast differentiation, chondrocyte ..
  31. Hedgehog Signaling in Intestinal Tolerance and Inflammation
    Michelle M Muza-Moons; Fiscal Year: 2013
    ..Hedgehog paralogs Sonic (Shh) and Indian (Ihh) are expressed at low levels in intestinal epithelium into adulthood, although their role in intestinal homeostasis ..
  32. Benjamin D Humphreys; Fiscal Year: 2014
    ..Two Hh ligands are expressed in kidney, Indian hedgehog (Ihh) and Sonic hedgehog (Shh), and these are expressed by tubular epithelial cells...
  33. Human Endothelial Cell Differentiation
    Karen K Hirschi; Fiscal Year: 2013
    ..Using a hES cell culture system, we found that Indian Hedgehog (Ihh) promoted endothelial cell differentiation, as evidenced by gene/protein expression, morphology and DiI-AcLDL ..
  34. Developing an in vitro system for HCV propagation
    Ratna Ray; Fiscal Year: 2009
    ..We have developed growth of HCV genotype 1a (H77 strain) in immortalized human hepatocytes (IHH)...
  35. The Melanocortin-3 Receptor and Linear Growth
    James Yeh; Fiscal Year: 2004
    ..2) To determine the effect of elevated endogenous ACTH and/or exogenous gamma2-MSH on Indian hedgehog (Ihh) and parathyroid related protein (PTHrP) regulation of linear growth in the context of low glucocorticoid...
  36. The Role of the Hedgehog Signaling Pathway in Ovarian Follicle Development
    SUSAN QUIRK; Fiscal Year: 2009
    ..There are three mammalian hh proteins, sonic (shh), indian (ihh) and desert (dhh), and each of them signals through the receptor smoothened (smo)...
  37. Genetic and Morphologic Basis of Bat Wing Development
    KAREN SEARS; Fiscal Year: 2007
    ..In addition, understanding the normal roles of genes that also play a role in abnormal developmental events such as cancer (i.e., Ihh and BMP) will provide a knowledge base for additional healthcare-related biomedical research.
  38. Molecular Analysis of Uterine Receptivity
    Francesco DeMayo; Fiscal Year: 2006
    ..mouse in combination with DNA microarray technology, we recently demonstrated that the morphogen, Indian hedgehog, Ihh, is expressed in the murine uterus and, importantly, regulated by progesterone via its nuclear receptor...
  39. Molecular Mechanisms in Vertebrate Midbrain Development
    Seema Agarwala; Fiscal Year: 2010
    ..the role of individual HHgenes and all HH signaling by gene expression analyses of the shh-/-, Indian Hedgehog (ihh-/-), shh:ihh-l- and smoothened (smo-/-) mice (where all HHsignal is lost)...
  40. Role of Ptchd3 in Spermatogenesis
    Guo Zhang Zhu; Fiscal Year: 2010
    ..In vertebrates, there are three members of the Hh family, Sonic hedgehog (Shh), Indian hedgehog (Ihh) and Desert hedgehog (Dhh)...
  41. Hedgehog signaling in human hepatocellular carcinoma
    Xin Chen; Fiscal Year: 2006
    ..In our preliminary studies, we found that signaling molecules in hedgehog pathways, including, shh, ihh, ptch, smo, Gli1 and hip1, are expressed in both HCC cell lines and tissues...
  42. Modulation of Insulin Action by Testosterone in Men
    Nelly Pitteloud; Fiscal Year: 2010
    ..Therefore, if low T levels are shown to play a role in the pathogenesis of insulin resistance, T may well represent an important therapeutic modality for both preventing and treating the metabolic syndrome and type 2 diabetes in men. ..
  43. Individual Predoctoral Dental Scientist Fellowship
    SCOTT BAUR; Fiscal Year: 2004
    ..to identify, a new skeletogenic factor and to study its interaction with known bone regulators such as BMPs, Wnts, Ihh, PThrP; and Gli transcription factors...
  44. Genotype /phenotype correlations in infertility
    LAWRENCE LAYMAN; Fiscal Year: 2006
    ..Patients with IHH constitute a severe reproductive-deficient phenotype with absent puberty, low serum gonadotropins, and infertility...
  45. Regulation of Parietal Endoderm Migration
    Laura Grabel; Fiscal Year: 2006
    ..We will therefore examine PE outgrowth on Matrigel, plus and minus fibronectin, with a particular focus on examining the role of integrins in promoting directed versus random migration. [unreadable] [unreadable] [unreadable]..
  46. Small RNAs in skeletogenesis
    Tatsuya Kobayashi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  47. FUNCTION OF STIMULATORY G PROTEIN (GS) IN BONE IN VIVO
    Henry Kronenberg; Fiscal Year: 2003
    ..system with parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor and Indian hedgehog (Ihh) signaling pathways...
  48. TYPE III COLLAGEN GENE EXPRESSION IN CARTILAGE
    SHERRILL ADAMS; Fiscal Year: 2007
    ..Finally, these studies will provide unique insights into the regulation of a complex locus which is, in essence, a gene within a gene. ..
  49. Methods for Modulating Hemato-Vascular Development
    MARGARET BARON; Fiscal Year: 2007
    ..abstract_text> ..
  50. 2007 CARTILAGE BIOLOGY & PATHOLOGY GORDON RESEARCH CONFERENCE
    Henry Kronenberg; Fiscal Year: 2007
    ..Special attention has been given to assure that the meeting takes full advantage of substantial representation of woman scientists as speakers and session chairs. ..
  51. NEUROENDOCRINE CONTROL OF PUBERTY
    Carol Foster; Fiscal Year: 2001
    ..Puberty results in remarkable changes in the neuroendocrine control of the reproductive hormones, and study of these changes should lead to a better understanding of the pathophysiology of reproductive abnormalities and infertility. ..
  52. SONIC HEDGEHOG SIGNALING IN ODONTOGENESIS
    Eiki Koyama; Fiscal Year: 2003
    ..The results of the project will provide key information on morphogenetic and cellular signals responsible for initiation and progression of odontogenesis. ..
  53. Gene Expression Core Facility
    Henry Kronenberg; Fiscal Year: 2003
    ..lectures given by Core Facility Scientific directors to explain the technology and its uses; D. a lecture series involving invited speakers from the Boston area using the technology in imaginative ways. ..
  54. PTHrP on normal osteoblast differentiation and function
    RAMIRO TORIBIO; Fiscal Year: 2008
    ..Dr. Thomas Rosol's laboratory will provide an excellent environment for developing the skills necessary to become a successful independent researcher. ..
  55. Functional Activities of HCV Core Protein
    Ranjit Ray; Fiscal Year: 2005
    ....
  56. HCV ENVELOPE GLYCOPROTEINS AND VACCINE DEVELOPMENT
    Ranjit Ray; Fiscal Year: 2003
    ....
  57. QUALITATIVE NATURE OF ANTIBODIES TO HCV GLYCOPROTEIN SUBUNIT VACCINE IN HUMANS
    Ranjit Ray; Fiscal Year: 2009
    ..Our proposed complimentary experimental approaches in this vaccinated cohort will help in developing successful vaccine strategies for the intervention of the first crucial step of the HCV life cycle. ..
  58. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
    ..If the perichondrial cells in MCC share regulatory features with cells in SUT rather than in SOS, this assumption is not only erroneous but may lead to inappropriate treatment strategies. ..
  59. Integration of Signaling Pathways Regulating Chondrocyte Differentiation
    Sherrill L Adams; Fiscal Year: 2010
    ..The proposed experiments will provide significant insights into the roles these growth factors and hormones play in failure of normal skeletal growth, resulting in short stature. ..
  60. REGULATION OF CHONDROCYTE PROLIFERATION
    Maurizio Pacifici; Fiscal Year: 2002
    ....
  61. Signaling Molecules and Long Bone Formation
    Maurizio Pacifici; Fiscal Year: 2005
    ..It is far from clear how all these processes and events are regulated. Indian hedgehog (IHH) and retinoids are powerful signaling molecules...
  62. Mechanisms of Synovial Joint Formation
    Maurizio Pacifici; Fiscal Year: 2009
    ..The results will be invaluable in conceiving novel, directed and specific therapies to repair and restore malfunctioning joints common to aging individuals and otherwise affected patients. ..
  63. TRANCE REGULATION OF CHONDROCYTE MATURATION
    PAUL ODGREN; Fiscal Year: 2005
    ..is in fact a naturally-occurring TRANCE loss-of-function mutation, and that TRANCE signaling is independent of the Ihh/PTHrP cascade of growth regulation. Three specific aims are presented to test these hypotheses...
  64. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..