IGFBP-3

Summary

Gene Symbol: IGFBP-3
Description: insulin like growth factor binding protein 3
Alias: BP-53, IBP3, insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3, IGFBP-3, acid stable subunit of the 140 K IGF complex, binding protein 29, binding protein 53, growth hormone-dependent binding protein
Species: human

Top Publications

  1. pmc Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 120:174-8. 2011
  2. doi Insulin-like growth factor-binding protein-3 suppresses tumor growth via activation of caspase-dependent apoptosis and cross-talk with NF-κB signaling
    Jinfeng Han
    Department of Pathology, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298 0662, USA
    Cancer Lett 307:200-10. 2011
  3. ncbi Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer
    June M Chan
    Department of Epidemiology and Biostatistics and Urology, University of California at San Francisco, 94118, USA
    J Natl Cancer Inst 94:1099-106. 2002
  4. ncbi Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Detect Prev 31:408-16. 2007
  5. ncbi IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men
    Joellen M Schildkraut
    Program of Cancer Prevention, Detection and Control Research, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Cancer Epidemiol Biomarkers Prev 14:403-8. 2005
  6. ncbi Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo
    Gayathri R Devi
    Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, Oregon, USA
    Prostate 51:141-52. 2002
  7. ncbi cDNA microarray analysis with amplified RNA after isolation of intact cellular RNA from neoplastic and non-neoplastic prostate tissue separated by laser microdissections
    Paul Thelen
    Department of Urology, Georg August Universitat, D 37075 Gottingen, Germany
    Int J Oncol 24:1085-92. 2004
  8. ncbi Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis
    B Liu
    Department of Pediatrics, University of California, Los Angeles, California 90095 1752, USA
    J Biol Chem 275:33607-13. 2000
  9. ncbi The amino-terminal region of insulin-like growth factor binding protein-3, (1-95)IGFBP-3, induces apoptosis of MCF-7 breast carcinoma cells
    Laurence Bernard
    Institut National de la Sante et de la Recherche Medicale, Unité 515, Croissance, Differenciation et Processus Tumoraux, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, Paris, France
    Biochem Biophys Res Commun 293:55-60. 2002
  10. ncbi Mechanisms underlying lack of insulin-like growth factor-binding protein-3 expression in non-small-cell lung cancer
    Yoon Soo Chang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Box 432, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Oncogene 23:6569-80. 2004

Research Grants

  1. Bryon E Petersen; Fiscal Year: 2014
  2. Mechanisms of CDX2 regulation of the IGF axis
    Duyen Dang; Fiscal Year: 2013
  3. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
  4. Energy Balance, IGF Dysregulation and Multiple Myeloma
    Brenda M Birmann; Fiscal Year: 2010
  5. Epidemiology Study of Colon Cancer Proteomic Prediction
    Kangmin Zhu; Fiscal Year: 2012
  6. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2009
  7. IGF-I LEVELS, IGF-I GENOTYPE, AND PROSTATE CANCER
    Noel Weiss; Fiscal Year: 2002
  8. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
  9. Insulin and IGF In female colon, breast, uterine cancer
    Howard Strickler; Fiscal Year: 2005
  10. Growth and Carcinogenic Potential in the Postnatal Mammary Gland
    Demetri D Spyropoulos; Fiscal Year: 2010

Detail Information

Publications217 found, 100 shown here

  1. pmc Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk
    Monica McGrath
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Gynecol Oncol 120:174-8. 2011
    ..Our hypothesis is that variant alleles in key genes involved in the IGF pathway will influence the development of endometrial cancer...
  2. doi Insulin-like growth factor-binding protein-3 suppresses tumor growth via activation of caspase-dependent apoptosis and cross-talk with NF-κB signaling
    Jinfeng Han
    Department of Pathology, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 East Marshall Street, Richmond, VA 23298 0662, USA
    Cancer Lett 307:200-10. 2011
    ..The use of IGFBP-3 as a cancer therapeutic with this distinctive suppression mechanism may offer alternate means to treat chemotherapy resistant tumors...
  3. ncbi Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer
    June M Chan
    Department of Epidemiology and Biostatistics and Urology, University of California at San Francisco, 94118, USA
    J Natl Cancer Inst 94:1099-106. 2002
    ....
  4. ncbi Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Detect Prev 31:408-16. 2007
    ..We wanted to study if these polymorphisms or any haplotypes of the IGF1 and the IGFBP3 genes are associated with CRC...
  5. ncbi IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men
    Joellen M Schildkraut
    Program of Cancer Prevention, Detection and Control Research, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Cancer Epidemiol Biomarkers Prev 14:403-8. 2005
    ..Further research is needed to confirm these findings...
  6. ncbi Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo
    Gayathri R Devi
    Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, Oregon, USA
    Prostate 51:141-52. 2002
    ..Insulin-like growth factor binding protein (IGFBP-3) levels are significantly reduced in malignant prostate epithelial cells. In this study, we evaluated the role of endogenous IGFBP-3 on prostate cancer cell growth and tumorigenesis...
  7. ncbi cDNA microarray analysis with amplified RNA after isolation of intact cellular RNA from neoplastic and non-neoplastic prostate tissue separated by laser microdissections
    Paul Thelen
    Department of Urology, Georg August Universitat, D 37075 Gottingen, Germany
    Int J Oncol 24:1085-92. 2004
    ..Taken together, we present a novel method for the isolation of intact RNA from laser microdissection-derived prostate cancer tissue useful for downstream applications of real-time RT-PCR and cDNA microarrays...
  8. ncbi Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis
    B Liu
    Department of Pediatrics, University of California, Los Angeles, California 90095 1752, USA
    J Biol Chem 275:33607-13. 2000
    ..IGFBP-3 enhanced RXR response element and inhibited RARE signaling. Thus, RXR-alpha-IGFBP-3 interaction leads to modulation of the transcriptional activity of RXR-alpha and is essential for mediating the effects of IGFBP-3 on apoptosis...
  9. ncbi The amino-terminal region of insulin-like growth factor binding protein-3, (1-95)IGFBP-3, induces apoptosis of MCF-7 breast carcinoma cells
    Laurence Bernard
    Institut National de la Sante et de la Recherche Medicale, Unité 515, Croissance, Differenciation et Processus Tumoraux, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, Paris, France
    Biochem Biophys Res Commun 293:55-60. 2002
    ..These results provide further evidence that the N-terminal proteolytic fragment of IGFBP-3 has a functional role...
  10. ncbi Mechanisms underlying lack of insulin-like growth factor-binding protein-3 expression in non-small-cell lung cancer
    Yoon Soo Chang
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Box 432, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Oncogene 23:6569-80. 2004
    ..Thus interference with Sp-1 transactivation by MeCP2 may contribute to the transcriptional defect of IGFBP-3 expression in NSCLC cells with methylated promoter...
  11. pmc Immunohistochemical expression of insulin-like growth factor binding protein-3 in invasive breast cancers and ductal carcinoma in situ: implications for clinicopathology and patient outcome
    Sarah B Vestey
    University of Bristol, Department of Clinical Sciences at South Bristol Surgery, Bristol Royal Infirmary, Bristol, UK
    Breast Cancer Res 7:R119-29. 2005
    ....
  12. ncbi Nonsecreted insulin-like growth factor binding protein-3 (IGFBP-3) can induce apoptosis in human prostate cancer cells by IGF-independent mechanisms without being concentrated in the nucleus
    Nisan Bhattacharyya
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:24588-601. 2006
    ..These results indicate that IGFBP-3 can induce apoptosis in an IGF-independent manner without being secreted or concentrated in the nucleus...
  13. ncbi Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States
    M L Slattery
    University of Utah, Salt Lake City, Utah 84108, USA
    Breast Cancer Res Treat 104:197-209. 2007
    ..An insulin-related pathway to breast cancer has been hypothesized...
  14. pmc IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53
    Takako Kawasaki
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Neoplasia 9:1091-8. 2007
    ..Our data suggest complex relationship between global genomic/epigenomic phenomena (such as MSI/CIMP), single molecular events (e.g., IGFBP3 methylation, TP53 mutation, and TGFBR2 mutation), and the related pathways...
  15. ncbi Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia
    J Zapf
    Department of Medicine, University Hospital, Zurich CH 8091, Switzerland
    J Biol Chem 265:14892-8. 1990
    ..It is likely that the different IGFBPs modulate auto-/paracrine and endocrine effects of IGFs on growth and metabolism in a different and specific manner...
  16. ncbi Insulin-like growth factor (IGF) binding protein-3 interacts with the type 1 IGF receptor, reducing the affinity of the receptor for its ligand: an alternative mechanism in the regulation of IGF action
    S Mohseni-Zadeh
    Institut National de la Sante et de la Recherche Medicale, U 142, Hopital Saint Antoine, Paris, France
    Endocrinology 138:5645-8. 1997
    ..The present results provide the first evidence that IGFBP-3 may inhibit IGF binding to IGFR-1, and hence limit IGF action via a cellular mechanism that is different from the extracellular mechanism of sequestration...
  17. ncbi Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators
    C Deal
    Department of Pediatrics, Universite de Montreal, Quebec, Canada
    J Clin Endocrinol Metab 86:1274-80. 2001
    ..The IGFBP3 promoter region deserves investigation as a locus where polymorphic variation occurs frequently and may influence GH responsiveness, somatic growth, and possibly cancer risk...
  18. ncbi Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase. Effects on the insulin-like growth factor signaling pathway
    Jean Marc Ricort
    Institut National de la Sante et de la Recherche Medicale, Unité 515, Assistance Publique Hopitaux de Paris, Universite Paris VI, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
    J Biol Chem 277:19448-54. 2002
    ....
  19. ncbi Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer
    Ho Young Lee
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 62:3530-7. 2002
    ....
  20. ncbi Correlation between insulin-like growth factor-binding protein-3 promoter methylation and prognosis of patients with stage I non-small cell lung cancer
    Yoon Soo Chang
    Department of Thoracic Head, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:3669-75. 2002
    ..Hypermethylation of the promoter represses the expression of the IGFBP-3 gene. The purpose of this study was to determine whether the methylation status of IGFBP-3 promoter influences the prognosis of non-small cell lung cancer (NSCLC)...
  21. ncbi Insulin-like growth factor-binding protein-3 gene -202 A/C polymorphism is correlated with advanced disease status in prostate cancer
    Lizhong Wang
    Department of Urology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Cancer Res 63:4407-11. 2003
    ..Because of the significant differences in incidence of clinically evident PCa according to racial backgrounds, the conjecture should be further examined in different racial populations...
  22. ncbi Polymorphic variation at the -202 locus in IGFBP3: Influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 107:60-4. 2003
    ..Our data do not demonstrate a significant influence of this locus on breast cancer risk, but we cannot exclude a minor influence or an influence confined to subgroups...
  23. ncbi Genetic polymorphisms in the IGFBP3 gene: association with breast cancer risk and blood IGFBP-3 protein levels among Chinese women
    Zefang Ren
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Cancer Epidemiol Biomarkers Prev 13:1290-5. 2004
    ..05). These results indicated that IGFBP3 polymorphisms may be associated with the level of blood IGFBP-3 protein and an increased risk of breast cancer...
  24. ncbi Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review
    Olivia Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:2-19. 2005
    ..Further large studies, or combined analysis of data from existing studies, are needed to quantify these effects more precisely...
  25. ncbi Polymorphisms in the IGF-1 and IGFBP 3 promoter and the risk of breast cancer
    Kerstin Wagner
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Breast Cancer Res Treat 92:133-40. 2005
    ..The interaction between the IGF-1 and its receptor is mainly regulated by a binding protein, IGFBP 3. We studied a CA repeat polymorphism 969 bp upstream of the transcription start site in the IGF-1 gene and an A-..
  26. pmc Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study
    F Canzian
    International Agency for Research on Cancer, Lyon, France
    Br J Cancer 94:299-307. 2006
    ..Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians...
  27. ncbi Insulin-like growth factor binding protein 3 has opposing actions on malignant and nonmalignant breast epithelial cells that are each reversible and dependent upon cholesterol-stabilized integrin receptor complexes
    C Burrows
    Department of Clinical Sciences at North Bristol, IGFs and Metabolic Endocrinology Group, University of Bristol, The Medical School, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB, United Kingdom
    Endocrinology 147:3484-500. 2006
    ..In summary, with three breast epithelial cell lines, IGFBP-3 had positive or negative effects on growth and survival dependent upon the status of cholesterol-stabilized integrin receptor complexes...
  28. ncbi Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers
    Kunitoshi Tomii
    Department of Cancer and Thoracic Surgery, Shikata Laboratory, Advanced Science Research Center, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Int J Cancer 120:566-73. 2007
    ..079). In summary, our results showed that IGFBP-3 methylation played an important role in the silencing of its expression, suggesting that IGFBP-3 may act as a tumor suppressor gene in several human cancers examined...
  29. ncbi CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3
    S Y Chun
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0682, USA
    Oncogene 26:4725-9. 2007
    ..These data demonstrate for the first time that (1) CDX2 can function as a transcriptional repressor, and (2) one mechanism by which CDX2 promotes anchorage-independent growth is by transcriptional repression of IGFBP-3...
  30. ncbi Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma
    P L Torng
    Department of Obstetric and Gynecology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Oncogene 27:2137-47. 2008
    ..Our results provide evidence and indicate that IGFBP-3 plays an important role as an invasion-metastasis suppressor in ovarian EC...
  31. ncbi Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population: results of the Study of Health in Pomerania (SHIP)
    Nele Friedrich
    Institute for Community Medicine, Ernst Moritz Arndt University, Walther Rathenau Strasse 48, D 17487 Greifswald, Germany
    Growth Horm IGF Res 18:228-37. 2008
    Insulin-like growth factor I (IGF-1), which is mostly carried by IGF binding protein 3 (IGFBP-3), mediates endocrine actions of growth hormone and represents an important prognostic factor for systemic diseases...
  32. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
    ..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women...
  33. pmc IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women
    Aimee A D'Aloisio
    Epidemiology Branch, National Institute of Environmental Health Sciences, P O Box 12233, Mail Drop A3 05, Research Triangle Park, NC 27709, USA
    Cancer Epidemiol Biomarkers Prev 18:954-66. 2009
    ..Our study supports that common IGFBP-3 SNPs, especially rs2854746, influence plasma IGFBP-3 levels among African Americans and Caucasians but provides less evidence that IGF-I SNPs affect plasma IGF-I levels...
  34. doi IGFBP3 polymorphisms and risk of cancer: a meta-analysis
    Li Li
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    Mol Biol Rep 37:127-40. 2010
    ..Further large study combining both IGFBP3 A-202C and Gly32Ala SNPs on different types of cancer in different populations were needed to validate former results...
  35. doi Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk
    Elisabeth Feik
    Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria
    Cancer Causes Control 21:91-7. 2010
    ..The purpose of this study was to examine the association of genetic variants in IGF1 (rs6214, rs6220, and rs35767) and IGFBP3 (rs2854744 and rs2854746) with risk of colorectal polyps and colorectal cancer...
  36. doi Insulin-like growth factor binding protein-3 gene methylation and protein expression in gastric adenocarcinoma
    Carolina Oliveira Gigek
    Disciplina de Genetica, Departamento de Morfologia e Genética, Universidade Federal de Sao Paulo, SP, Brazil
    Growth Horm IGF Res 20:234-8. 2010
    ..The aim of this study was to evaluate IGFBP-3 protein expression, its correlation with gene promoter methylation pattern in gastric carcinogenesis and with clinicopathological characteristics...
  37. doi Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells
    Lujia Gribben
    Hormones and Cancer Division, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Cancer Lett 317:41-8. 2012
    ..This study demonstrates that endogenous IGFBP-3 modulates adhesion-migration dynamics in EC cells, implying that it may be important in regulating metastasis in this disease...
  38. ncbi Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma
    P Cohen
    Department of Pediatrics, Stanford University Medical Center, California 94305
    J Clin Endocrinol Metab 75:1046-53. 1992
    ..We speculate that PSA may serve to modulate IGF function within the reproductive system or in prostate cancer by altering IGF-IGFBP-3 interactions...
  39. ncbi Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions
    S Rajaram
    Mineral Metabolism Laboratory, Jerry L Pettis Memorial Veterans Administration Medical Center, Loma Linda, California 92357, USA
    Endocr Rev 18:801-31. 1997
  40. ncbi Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases
    T L Gibson
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Growth Horm IGF Res 9:241-53. 1999
    ....
  41. ncbi Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma
    Y Gui
    Department of Physiology, University of Manitoba, Winnipeg, Canada R3E 0W3
    J Clin Endocrinol Metab 86:2104-10. 2001
    ..These data indicate that FN may have a role in the transportation of IGFBP-3 and IGF-I in the circulation and the sequestration of these proteins in tissues...
  42. ncbi Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding
    C K Buckway
    Department of Pediatrics, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    J Clin Endocrinol Metab 86:4943-50. 2001
    ..The mutants provide a tool for future studies directed at IGF-dependent and IGF-independent actions of IGF-binding protein-3...
  43. ncbi Insulin-like growth factor (IGF)-binding protein-3 mutants that do not bind IGF-I or IGF-II stimulate apoptosis in human prostate cancer cells
    Jiang Hong
    Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:10489-97. 2002
    ..These results indicate that IGF-independent mechanisms are major contributors to IGFBP-3-induced apoptosis in PC-3 cells and may play a wider role in the antiproliferative and antitumorigenic actions of IGFBP-3...
  44. ncbi Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation
    Roopmathy Rajah
    Department of Pediatrics, Mattel Children s Hospital at UCLA, 90095, USA
    Cell Growth Differ 13:163-71. 2002
    ..These findings confirm that IGFBP-3 is essential for TNF-alpha-induced apoptosis in PC-3 cells and that this IGFBP-3 effect includes the inactivation of Bcl-2 through serine phosphorylation...
  45. ncbi Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China
    Stephanie J London
    Epidemiology Branch and Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 94:749-54. 2002
    ..In a prospective study of men in Shanghai, China, we examined the association between serum levels of IGF-I and IGFBP-3 and the subsequent risk of lung cancer...
  46. ncbi Enhanced expression of insulin-like growth factor binding protein-3 sensitizes the growth inhibitory effect of anticancer drugs in gastric cancer cells
    Dae Yeol Lee
    Department of Pediatrics and Research Institute of Clinical Medicine, Chonbuk National University Medical School, 634 18, Keumam Dong, Jeonju, Jeonbuk 561 712, South Korea
    Biochem Biophys Res Commun 294:480-6. 2002
    ..Our data suggest that IGFBP-3 may have an important role in the biology of gastric cancer cell growth and provides a potential marker for predicting the responsiveness to anticancer drugs...
  47. ncbi Evidence implicating a mid-region sequence of IGFBP-3 in its specific IGF-independent actions
    A D Hollowood
    University Department of Surgery, Bristol Royal Infirmary, Bristol, BS2 8HW, United Kingdom
    J Cell Biochem 86:583-9. 2002
    ....
  48. ncbi Plasma from patients undergoing major open surgery stimulates in vitro tumor growth: Lower insulin-like growth factor binding protein 3 levels may, in part, account for this change
    Irena Kirman
    Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Surgery 132:186-92. 2002
    ..This study assessed the effect of plasma from patients who underwent major open (OS) or laparoscopic surgery (LS) on in vitro tumor cell growth...
  49. ncbi Role of insulin-like growth factor binding protein-3 in breast cancer cell growth
    Lynette J Schedlich
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Sydney, Australia
    Microsc Res Tech 59:12-22. 2002
    ..It may also act directly in the nucleus by enhancing the activity of retinoid X receptor-alpha and thereby promote apoptosis. All of the above phenomena will be discussed with particular emphasis on the growth of breast cancer cells...
  50. ncbi Expression of IGFBP-3 by human retinal endothelial cell cultures: IGFBP-3 involvement in growth inhibition and apoptosis
    Polyxenie E Spoerri
    Department of Pharmacology and Therapeutics, University of Florida, PO Box 100267, Gainesville, FL 32610 0267, USA
    Invest Ophthalmol Vis Sci 44:365-9. 2003
    ....
  51. ncbi Functional cloning of IGFBP-3 from human microvascular endothelial cells reveals its novel role in promoting proliferation of primitive CD34+CD38- hematopoietic cells in vitro
    Li qin Liu
    ViaCell Inc, Worcester, MA 01605, USA
    Oncol Res 13:359-71. 2003
    ....
  52. ncbi Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization
    Kuk Wha Lee
    Division of Pediatric Endocrinology, Mattel Children s Hospital, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 279:469-76. 2004
    ..Suppression of IGFBP-3 internalization by TfR1 blockade inhibited IGFBP-3-induced apoptosis. Together, these data indicate that the actions of IGFBP-3 are mediated by internalization via distinct endocytic pathways...
  53. ncbi A polymorphic locus in the promoter region of the IGFBP3 gene is related to mammographic breast density
    Joe H Lai
    Centre for Research in Women s Health, University of Toronto, 8790 Bay Street, Toronto, Ontario, M5G 1N8 Canada
    Cancer Epidemiol Biomarkers Prev 13:573-82. 2004
    ..A high circulating level of insulin-like growth factor-I (IGF-I) and low IGF binding protein 3 (IGFBP-3) level have been associated with increased breast density in premenopausal women...
  54. ncbi Insulin-like growth factor binding protein-3 expression is associated with growth stimulation of T47D human breast cancer cells: the role of altered epidermal growth factor signaling
    Alison J Butt
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    J Clin Endocrinol Metab 89:1950-6. 2004
    ....
  55. ncbi Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer
    Martha L Slattery
    Health Research Center, School of Medicine, University of Utah, Salt Lake City, 84108, USA
    Cancer Epidemiol Biomarkers Prev 13:1206-14. 2004
    ..We hypothesize that genetic polymorphisms of insulin receptor substrates (IRS-1 and IRS-2), IGF-I, and IGFBP-3 alter colorectal cancer risk because of their roles in the insulin-related signaling pathway...
  56. pmc p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia
    Adda Grimberg
    Division of Pediatric Endocrinology, The Children s Hospital of Philadelphia, Abramson Research Center, Room 802, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104 4318, USA
    J Clin Endocrinol Metab 90:3568-74. 2005
    ..Because IGFBP-3 can inhibit growth and induce apoptosis in IGF-dependent and IGF-independent manners, its induction by DNA damage and hypoxia suggest IGFBP-3 plays a role in the physiologic protection against aberrant cell growth...
  57. ncbi Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells
    Ho Keun Yi
    Department of Biochemistry, School of Dentistry, Chonbuk National University, Jeonju, Republic of Korea
    Biochem Biophys Res Commun 330:760-7. 2005
    ....
  58. ncbi Insulin-like growth factor binding protein 3 in inflammatory bowel disease
    Irena Kirman
    Department of Surgery, Columbia University, New York, New York, USA
    Dig Dis Sci 50:780-4. 2005
    ..The level of intact IGFBP-3 is decreased in IBD patients with moderate to severe disease activity. This decrease may be linked to altered IGFBP-3 production or to increased cleavage by proteases other than MMP-9...
  59. ncbi Insulin-like growth factor polymorphisms and colorectal cancer risk
    Libby M Morimoto
    Fred Hutchinson Cancer Research Center, Cancer Prevention, 1100 Fairview Avenue North, M4 B402, Seattle WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:1204-11. 2005
    ..01). The current study provides some support for a role of IGFs in colorectal cancer etiology, particularly in mediating the relationship of common risk factors (physical activity, BMI, and postmenopausal hormone use)...
  60. ncbi Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes
    Sophie S Y Chan
    Kolling Institute of Medical Research, Royal North Shore Hospital, Pacific Highway, St Leonards 2065, NSW, Australia
    J Clin Endocrinol Metab 90:6588-95. 2005
    ..Transgenic mice overexpressing IGF binding protein-3 (IGFBP-3) have insulin resistance with reduced uptake of 2-deoxyglucose in muscle and adipose tissue...
  61. ncbi Genetic, anthropometric, and lifestyle factors associated with IGF-1 and IGFBP-3 levels in Hispanic and non-Hispanic white women
    M L Slattery
    Health Research Center, University of Utah, Salt Lake City, UT 84117, USA
    Cancer Causes Control 16:1147-57. 2005
    ..These differences could be due to the combined effects of genetic and behavioral factors which could account for ethnic differences in the risk of breast cancer and other chronic diseases...
  62. ncbi IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer
    Ali Al-Zahrani
    CR UK Department of Oncology, Cambridge, UK
    Hum Mol Genet 15:1-10. 2006
    ..More specifically and consistent with experimental models, our data suggest that higher IGF1 levels may increase the risk of breast cancer but higher IGFBP3 levels may be protective...
  63. ncbi Differential expression of IGF-binding protein-3 in normal and malignant colon and its influence on apoptosis
    P J Jenkins
    Department of Endocrinology, William Harvey Research Institute, Barts and the London Queen Mary s School of Dentistry, John Vane Building, Charterhouse Square, UK
    Endocr Relat Cancer 12:891-901. 2005
    ..These effects are mediated in part by the PI-3K pathway in contrast to the MAP kinase pathway used by IGF-I...
  64. ncbi Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/proteasome-dependent proteolysis
    Frédéric R Santer
    Cell Metabolism and Differentiation Research Group, Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria
    Cancer Res 66:3024-33. 2006
    ..Moreover, we show that IGFBP-3, if ectopically expressed in the nucleus, can induce apoptotic cell death. These results suggest that ubiquitin/proteasome-mediated proteolysis of IGFBP-3 may contribute to down-regulation of apoptosis...
  65. ncbi Differential regulation of IGFBP-3 by the androgen receptor in the lineage-related androgen-dependent LNCaP and androgen-independent C4-2 prostate cancer models
    Satoko Kojima
    The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Prostate 66:971-86. 2006
    ..Despite evidence implicating insulin-like growth factor binding protein-3 (IGFBP-3) as a growth inhibitor of prostate cancer (CaP), little is known about changes in its regulation and function during progression to androgen independence...
  66. ncbi Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB
    A C Williams
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, Bristol, UK
    Cell Death Differ 14:137-45. 2007
    ..We propose that IGFBP-3 is a non-toxic NF-kappaB inhibitor, which could be used as an adjuvant in the treatment of colon cancer...
  67. ncbi Gender differences in the insulin-like growth factor axis response to a glucose load
    D E Flanagan
    Department of Endocrinology, Peninsula Medical School, Derriford Hospital, Plymouth, UK
    Acta Physiol (Oxf) 187:371-8. 2006
    ..The aim of our study was to examine the response of the IGFs and their binding proteins to an intravenous load of glucose in a cohort of young men and women with normal glucose tolerance...
  68. ncbi Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort
    Iona Cheng
    Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California San Francisco, San Francisco, California, USA
    Cancer Epidemiol Biomarkers Prev 15:1993-7. 2006
    ..Our results suggest that common genetic variation in the IGFBP1 and IGFBP3 genes do not substantially influence prostate and breast cancer susceptibility...
  69. ncbi Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study
    Sandra L Deming
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Breast Cancer Res Treat 104:309-19. 2007
    ..9) for the N/A-A/A genotypes (rs6413441). Taken together, these data suggest that polymorphisms in the IGF-1R and IGFBP3 genes may be associated with altered survival among subgroups of breast cancer patients defined by menopausal status...
  70. ncbi Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo
    Hae Soon Kim
    Department of Pediatrics, Ewha Womans University, Seoul, 120 750 Korea
    Pediatr Res 61:159-64. 2007
    ....
  71. ncbi Association of total insulin-like growth factor-I, insulin-like growth factor binding protein-1 (IGFBP-1), and IGFBP-3 levels with incident coronary events and ischemic stroke
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA, and Department of Medicine, Lady Davis Research Institute of Jewish General Hospital, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 92:1319-25. 2007
    ..Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults...
  72. pmc Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study
    Rulla M Tamimi
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Breast Cancer Res 9:R18. 2007
    ....
  73. ncbi Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, MA 02142, USA
    Hum Genet 122:129-39. 2007
    ....
  74. ncbi IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans
    Wenndy Hernandez
    Cancer Biology Program, Division of Biological Sciences, The University of Chicago, Chicago, IL 60637, USA
    Carcinogenesis 28:2154-9. 2007
    ..Our study adds clarity and further support to the previous findings, implicating serum IGFBP-3 levels and the IGFBP-3 -202 A/C SNP in prostate carcinogenesis...
  75. doi Serum insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-3, leptin concentrations and insulin resistance in benign and malignant epithelial ovarian tumors in postmenopausal women
    Ibrahim Serdar Serin
    Department of Obstetrics and Gynecology, Erciyes University Medical Faculty, Kayseri, Turkey
    Gynecol Endocrinol 24:117-21. 2008
    ....
  76. doi Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels
    Caroline Diorio
    Breast Cancer Functional Genomics Group and McGill Centre for Bioinformatics, McGill University, Montreal, QC, Canada
    Cancer Epidemiol Biomarkers Prev 17:880-8. 2008
    ....
  77. pmc Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:282-8. 2009
    ..Nonetheless, the data are consistent with the hypothesis that IGF-1- and IL-6-related gene variation influences susceptibility to multiple myeloma and warrant confirmation in larger populations...
  78. doi Genetic and plasma variation of insulin-like growth factor binding proteins in relation to prostate cancer incidence and survival
    Mattias Johansson
    International Agency for Research against Cancer, Lyon, France
    Prostate 69:1281-91. 2009
    ..We analyzed genetic variation within genes coding for IGF binding proteins in relation to prostate cancer incidence and survival. We also investigated if circulating IGFBP3 affects prostate cancer-specific survival...
  79. pmc Unraveling insulin-like growth factor binding protein-3 actions in human disease
    Sherryline Jogie-Brahim
    Department of Pathology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0662, USA
    Endocr Rev 30:417-37. 2009
    ....
  80. doi Association between two functional polymorphisms of insulin-like growth factor binding protein 3 and colorectal cancer risk in a Chinese population
    Hao Xiang
    Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    J Toxicol Environ Health A 72:706-11. 2009
    ..Data suggest that the exon 1 G2133C missense variant of IGFBP3 may be a susceptibility factor for colorectal cancer in Chinese subjects. Larger studies are warranted to validate our findings in a Chinese population...
  81. doi Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility
    Petra Massoner
    Department of Urology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Endocr Relat Cancer 16:795-808. 2009
    ..These newly described mechanisms of IGFBP-3 can be of importance for tumor progression and support a role of IGFBP-3 in therapeutic settings...
  82. pmc Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 126:180-90. 2010
    ..These results suggest that genetic variants and circulating levels of IGFBP-3 may play a role in the early stage of breast carcinogenesis...
  83. doi Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients
    M Corbo
    Department of Neurology and Lab Neuroscience, Dino Ferrari Center, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Eur J Neurol 17:398-404. 2010
    ..In this context, little information is available on free IGF-1, the bioactive form of IGF-1, in amyotrophic lateral sclerosis (ALS)...
  84. pmc Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Carcinogenesis 30:2042-6. 2009
    ..Of particular interest was the IGFBP3 SNP rs2270628, which was associated with both increased IGF1 plasma levels and higher ovarian cancer risk...
  85. doi IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer
    I Ibanez de Caceres
    Oncology Research Laboratory, Research Unit, FIB La Paz University Hospital, Madrid, Spain
    Oncogene 29:1681-90. 2010
    ....
  86. doi A 3'-untranslated region polymorphism in IGF1 predicts survival of non-small cell lung cancer in a Chinese population
    Mingfeng Zhang
    Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China
    Clin Cancer Res 16:1236-44. 2010
    ..Single nucleotide polymorphisms (SNP) in IGF1 and IGFBP3 have been reported to be associated with the expression of the IGF-I/IGFBP3 axis. Therefore, we hypothesized that SNPs in these two genes were associated with lung cancer survival...
  87. pmc Functional modulation of IGF-binding protein-3 expression in melanoma
    Altaf A Dar
    Auerback Melanoma Research Laboratory, Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA
    J Invest Dermatol 130:2071-9. 2010
    ..Our study results indicate that silencing of IGFBP3 in melanoma is due to the methylation of its promoter, and that overexpression of IGFBP3 induces apoptosis and suppresses cell survival and growth...
  88. pmc IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin
    Jamie McIntosh
    School of Clinical Sciences, IGFs and Metabolic Endocrinology Group, Learning and Research Building, 2nd Floor, University of Bristol, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Biol Chem 285:38788-800. 2010
    ..The levels of fibronectin and IGFBP-3 within breast tumors may determine their dependence on EGFR and their response to therapies targeting this receptor...
  89. doi Host genetic variants in the IGF binding protein-3 impact on survival of patients with advanced gastric cancer treated with palliative chemotherapy
    Francesco Graziano
    Department of Onco Hematology, Division of Oncology, Azienda Ospedale San Salvatore, Pesaro, Italy
    Pharmacogenomics 11:1247-56. 2010
    ..We investigated whether IGFBP-3 SNPs determining high IGFBP-3 circulating levels are associated with improved survival of patients with advanced gastric cancer treated with palliative chemotherapy...
  90. pmc Insulin-like growth factor-binding protein-3 (IGFBP-3) blocks the effects of asthma by negatively regulating NF-κB signaling through IGFBP-3R-mediated activation of caspases
    Yong Chul Lee
    Department of Internal Medicine, School of Medicine, Chonbuk National University, Jeonju 56 182, South Korea
    J Biol Chem 286:17898-909. 2011
    ..The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease...
  91. pmc Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury
    Jennifer L Kielczewski
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610 0267, USA
    Am J Pathol 178:1517-28. 2011
    ....
  92. doi Genotypes and phenotypes of IGF-I and IGFBP-3 in breast tumors among Chinese women
    Biyun Qian
    Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Huan Hu Xi Rd, He Xi District, Tianjin, 300060, People s Republic of China
    Breast Cancer Res Treat 130:217-26. 2011
    ....
  93. doi Circulating insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 levels and postmenopausal breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) cohort
    Catherine Schairer
    Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, 20852 7244, USA
    Horm Cancer 1:100-11. 2010
    ..Further research should emphasize larger studies, including pooled analyses, analyses by cancer subtype, improved exposure assessment, and possible mechanisms...
  94. pmc Insulin-like growth factor binding protein-3 suppresses vascular endothelial growth factor expression and tumor angiogenesis in head and neck squamous cell carcinoma
    Seung Hyun Oh
    College of Pharmacy, Gachon University, Incheon
    Cancer Sci 103:1259-66. 2012
    ..Taken together, these results support the hypothesis that IGFBP-3 has anti-angiogenic activity in HNSCC, at least in part due to IGF-independent suppression of VEGF production from vascular endothelial cells and cancer cells...
  95. doi IGFBP-3 methylation-derived deficiency mediates the resistance to cisplatin through the activation of the IGFIR/Akt pathway in non-small cell lung cancer
    M Cortes-Sempere
    Instituto de Investigaciones Biomedicas CSIC UAM, CIBER de Enfermedades Raras CIBERER, Madrid, Spain
    Oncogene 32:1274-83. 2013
    ..84 and 0.9, respectively, (P=0.0062). We present a biomarker test that could provide clinicians with a robust tool with which to decide on the use of CDDP, improving patient clinical outcomes...
  96. pmc Possible roles of insulin, IGF-1 and IGFBPs in initiation and progression of colorectal cancer
    Bo Jiang
    Bo Jiang, Xin Zhang, Dong Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China
    World J Gastroenterol 20:1608-13. 2014
    ..To investigate the roles of serum insulin, insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding proteins (IGFBPs) in the initiation and progression of colorectal cancer...
  97. pmc Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies
    Wensen Chen
    Laboratory of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing, China
    Eur J Hum Genet 17:1668-75. 2009
    ..001). In conclusion, circulating levels of IGF1, IGFBP3 and IGFBP3 A-202C play a crucial role in carcinogenesis and could serve as susceptibility biomarkers for cancer development...
  98. pmc Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community
    Carolyn S P Lam
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 30:1479-84. 2010
    ..The metabolic and genetic correlates of circulating insulin-like growth factor-1 (IGF-1) and its main circulating carrier, IGF-1-binding-protein-3 (IGFBP-3), are unclear...
  99. ncbi Induction of the growth inhibitor IGF-binding protein 3 by p53
    L Buckbinder
    Department of Molecular Genetics, Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, New Jersey 08543 4000, USA
    Nature 377:646-9. 1995
    ..Our results indicate that IGF-BP3 may link p53 to potential novel autocrine/paracrine signalling pathways and to processes regulated by or dependent on IGF(s), such as cellular growth, transformation and survival...
  100. ncbi Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit
    L J Schedlich
    Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia
    J Biol Chem 275:23462-70. 2000
    ..Together these results suggest that the NLSs within the C-terminal domain of IGFBP-3 and IGFBP-5 are required for importin-beta-dependent nuclear uptake and probably also accumulation through mediating binding to nuclear components...
  101. ncbi Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma
    Tadashi Hanafusa
    Isotope Center, Okayama University, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Cancer Lett 176:149-58. 2002
    ..As IGFBP-3 functions like a tumor suppressor gene, it may be used as a therapeutic target for HCC...

Research Grants66

  1. Bryon E Petersen; Fiscal Year: 2014
    ..This knowledge will help to guide the development of strategies for the therapeutic use of stem cell transplants for the treatment of liver disease. ..
  2. Mechanisms of CDX2 regulation of the IGF axis
    Duyen Dang; Fiscal Year: 2013
    ..This line of investigation provides the first insights into how CDX2 can function as both a cell growth promoter and suppressor. This approach would hopefully lead to novel clinical strategies for colon cancer prevention and therapy. ..
  3. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..biomarkers of breast cancer risk: mammographic density;plasma insulin-like growth factor 1 (IGF-1), IGF binding protein 3, estrone, estradiol, androstenedione and sex hormone binding globulin...
  4. Energy Balance, IGF Dysregulation and Multiple Myeloma
    Brenda M Birmann; Fiscal Year: 2010
    ..association of obesity, adult weight gain, physical activity, and prediagnostic plasma levels of IGF-1, IGF binding protein 3, acid-labile subunit and C-peptide with MM...
  5. Epidemiology Study of Colon Cancer Proteomic Prediction
    Kangmin Zhu; Fiscal Year: 2012
    ..Proteomic early detection and prediction of colon cancer will contribute to the cure of the disease and the optimization of prevention/intervention strategies to reduce colon cancer occurrence. ..
  6. DYSREGULATION OF GLUCOSE HOMEOSTASIS IN AGING
    Nir Barzilai; Fiscal Year: 2009
    ..abstract_text> ..
  7. IGF-I LEVELS, IGF-I GENOTYPE, AND PROSTATE CANCER
    Noel Weiss; Fiscal Year: 2002
    ..abstract_text> ..
  8. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  9. Insulin and IGF In female colon, breast, uterine cancer
    Howard Strickler; Fiscal Year: 2005
    ....
  10. Growth and Carcinogenic Potential in the Postnatal Mammary Gland
    Demetri D Spyropoulos; Fiscal Year: 2010
    ..stroma and stromal expression is repressed by estrogen;3) HoxC6 is a direct transcriptional repressor of IGF binding protein 3 (IGFBP3), and IGFBP3 upregulation occurs in HoxC6-downregulated mammary epithelial cell lines and HoxC6 ..
  11. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  12. Insulin Resistance and Adenomas of the Colorectum
    RALPH DAGOSTINO; Fiscal Year: 2003
    ....
  13. Insulin Resistance and Adenomas of the Colorectum
    Steven Haffner; Fiscal Year: 2003
    ..abstract_text> ..
  14. Insulin Resistance and Adenomas of the Colorectum
    Theodore Levin; Fiscal Year: 2003
    ..abstract_text> ..
  15. Insulin Resistance and Adenomas of the Colorectum
    Tim Byers; Fiscal Year: 2003
    ....
  16. Insulin Resistance and Adenomas of the Colorectum
    Mohammed Saad; Fiscal Year: 2003
    ..abstract_text> ..
  17. IGF binding protein-3 in beta cell apoptosis
    ROBERT FERRY JR; Fiscal Year: 2005
    ....
  18. IGF BINDING PROTEIN-3--REGULATION AND BIOLOGICAL ACTIONS
    Cheryl Conover; Fiscal Year: 1992
    ..Knowledge of the structure, function, and regulation of IGFBP-3 will have major implications for our understanding of the physiology and pathophysiology of IGF-I, as well as for applications of IGF-I in clinical medicine...
  19. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    Danielle M Robertson; Fiscal Year: 2011
    ....
  20. John J Krolewski; Fiscal Year: 2016
    ..Finally, Aim 3 tests the functional role of FLIP, determining if FLIP down-regulation can cooperate with pro- apoptotic cytokines to induce apoptosis and regression of normal prostate and PrCa in a murine model. ..
  21. Xiaolin Zi; Fiscal Year: 2014
    ..Our studies will determine if the proposed molecular target is correct, and may point to other enzymes and cytokines as potential targets of lycopene. ..
  22. Pregnancy Estrogens, Diet, and Breast Cancer Risk
    Leena Hilakivi Clarke; Fiscal Year: 2005
    ..associated with increased growth factor levels in nipple aspirate fluid, including EGF, TGFalpha and IGF-1/IGF binding protein 3. These aims will be studied in 200 pregnant women attending the Maternity Clinic at Solna in NAF will be ..
  23. DETERMINANTS OF STEROID HORMONES IN BLACK AND WHITE MEN
    Susan Gapstur; Fiscal Year: 2006
    ....
  24. Effects of Alcohol on Urinary Estrogen and Androgen Levels in Women
    Somdat Mahabir; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. Regulation of esophageal epithelial biology
    Hiroshi Nakagawa; Fiscal Year: 2007
    ..The research will provide a long-term framework for independent investigator status. ..
  26. WEIGHT LOSS IN OBESE BREAST CANCER SURVIVORS
    Zora Djuric; Fiscal Year: 2002
    ..This study should be useful to determine certain psychosocial are associated with extent of weight loss, and in turn whether weight loss is associated with changes in selected markers of breast cancer risk. ..
  27. Biomarkers of Ventricular and Vascular Remodeling
    Vasan Ramachandran; Fiscal Year: 2009
    ..aged third generation (Gen 3, minority Omni cohort included): insulin-like growth factor-1, IGF binding protein 3;hepatocyte growth factor;vascular endothelial growth factor and its soluble receptor [sFlt-1];angiopoietin-..
  28. Silibinin in Prostate Cancer Chemoprevention & Treatment
    Michael Pollak; Fiscal Year: 2004
    ..The work is justified by the favorable toxicity profile of silibinin, together with prior positive laboratory studies reported by our group and other investigators. ..
  29. Chronochemoprevention of Prostate Cancer
    Jack Burton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  30. IGF-I MODULATION BY 4-HPR AND BREAST CANCER RISK
    Umberto Veronesi; Fiscal Year: 1999
    ....
  31. Prostate Cancer: Impact of Fat & Flaxseed Modified Diet
    Wendy Demark Wahnefried; Fiscal Year: 2005
    ..This research has the potential to expand the scope of complementary treatment offered for prostate cancer, and may provide a solid foundation for efforts aimed at prevention. ..
  32. THE 4 CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    Kathy Baumgartner; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  33. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    Maria Martinez; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  34. FOUR-CORNERS BREAST CANCER STUDY
    Tim Byers; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  35. Role of IGFBP -3 in mediating p53-induced apoptosis
    Adda Grimberg; Fiscal Year: 2006
    ..These studies also reflect Dr. Grimberg?s long-term career goals of exploring the interrelatedness of endocrine and oncologic molecular biology principles and applying them to clinical problems of dysregulated growth. ..
  36. MECHANISMS OF EXERCISE MODULATION OF HUMAN GROWTH
    Dan Cooper; Fiscal Year: 2004
    ..abstract_text> ..
  37. Genetic Epidemiology of Breast Cancer: BRCA1 and BRCA2
    Susan Neuhausen; Fiscal Year: 2007
    ..This information can be used to assist women and their physicians in individual risk assessment, as well as to target women for specific prevention or treatment strategies based on their genetic risk factors. ..
  38. IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONS
    David Clemmons; Fiscal Year: 2002
    ....
  39. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David Clemmons; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  40. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2005
    ....
  41. Chaperones, ROS systems, & IGF-1:Roles in vascular aging
    David Clemmons; Fiscal Year: 2008
    ..abstract_text> ..
  42. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2007
    ..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..
  43. IGF AXIS IN ASTHMA
    Pinchas Cohen; Fiscal Year: 2002
    ..We believe that these studies may help us understand the dis-regulated growth of asthmatic airway smooth muscle and allow us to optimize our therapeutic approaches to this disease. ..
  44. The Role of IGF2 in Fetal Growth Restriction
    Pinchas Cohen; Fiscal Year: 2008
    ..abstract_text> ..
  45. Genomic and Non-Genomic Effects of IGFBP-3 on Apoptosis
    Pinchas Cohen; Fiscal Year: 2004
    ..If successful our findings may validate novel targets for clinical therapy development for use in men with CaP. ..
  46. Insulin Resistance and Colon Cancer in Blacks and Whites
    Temitope Keku; Fiscal Year: 2005
    ..The proposed project will advance the understanding of the role of insulin resistance in colon cancer among African Americans and whites. ..
  47. IGF-I: A Nutrition-Regulated Target in Prostate Cancer
    Pinchas Cohen; Fiscal Year: 2007
    ....
  48. Lung Cancer Chemoprevention using Deguelin
    Ho Young Lee; Fiscal Year: 2008
    ..abstract_text> ..
  49. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2007
    ..Hence, the proposed project is highly cost-efficient. ..
  50. Vitamin D Intake and Breast Cancer Survival
    Michelle Holmes; Fiscal Year: 2005
    ..A polymorphism in VDR (FOK1) has been shown to influence breast cancer risk. We hypothesize that women homozygous for this polymorphism will have an increased risk of death from breast cancer. ..
  51. The Role of Prolactin in the Etiology of Postmenopausal Breast Cancer
    Shelley Tworoger; Fiscal Year: 2008
    ..This potentially may affect public health by increasing our understanding of how breast cancer develops, which in turn can lead to a better understanding of how to prevent this disease. [unreadable] [unreadable]..
  52. IRON STATUS AND RISK OF CHD AND COLON CANCER
    Jing Ma; Fiscal Year: 2002
    ....
  53. USE OF ANTIOXIDANT SUPPLEMENTS AND OXIDATIVE DNA DAMAGE
    Marian Neuhouser; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  54. Inhibition of Androgen Receptor to treat Prostate Cancer
    Gayathri Devi; Fiscal Year: 2003
    ..Based on these data, future pharmacokinetic and toxicology animal studies will allow proceeding to human phase I testing in a timely and efficient manner. ..
  55. Early Diagnosis of Cervical Cancer
    SUBBI MATHUR; Fiscal Year: 2003
    ..We believe that serum IGF-II test could compliment the Pap test to reduce deaths by cervical cancer. ..
  56. REGULATION OF SKELETAL GROWTH IN RENAL FAILURE
    CHERYL SANCHEZ; Fiscal Year: 2003
    ....
  57. Antisense Morpholino Oligomers to Treat Retinopathy
    Gayathri Devi; Fiscal Year: 2003
    ..The primary goal of this grant is to identify the optimal antisense alphav PMO, dose and schedule that maximally decreases alpha V expression and inhibits retinopathy of prematurity. ..
  58. Epidemiology of IGF and Cardiovascular Events
    Robert Kaplan; Fiscal Year: 2005
    ....
  59. Postprandial glycemic response to 4-week low and high glycemic load diets
    Marian Neuhouser; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Aspartame Intake and the Risk of Cancer
    Eva Schernhammer; Fiscal Year: 2008
    ..Our results may help decision-makers formulate guidelines and direct future aspartame studies. Even a null finding would be important in this context. [unreadable] [unreadable] [unreadable]..
  61. Effects of Light at Night on Circadian System in Nurses
    Eva Schernhammer; Fiscal Year: 2008
    ..abstract_text> ..
  62. Diet and Genetic Risks for Prostate Cancer
    Marian Neuhouser; Fiscal Year: 2005
    ..To date, there are 718 confirmed cases of primary prostatic carcinoma. This proposed study will provide important information about prostate cancer etiology and suggest new strategies for prevention and control. ..
  63. Clock Genes, Night Work, and Breast Cancer Risk
    Eva Schernhammer; Fiscal Year: 2008
    ..The results from this study could help identify individuals who are more susceptible to night work than others, based on their genetic profile. ..
  64. A Pilot Trial of Oral Melatonin Supplementation in Breast Cancer Survivors
    Eva Schernhammer; Fiscal Year: 2007
    ..This pilot data could lay the groundwork for a large scale trial to assess the chemopreventive potential of melatonin in women, both with and without a personal history of breast cancer. [unreadable] [unreadable] [unreadable]..