IGF-IR

Summary

Gene Symbol: IGF-IR
Description: insulin like growth factor 1 receptor
Alias: CD221, IGFIR, IGFR, JTK13, insulin-like growth factor 1 receptor, IGF-I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2
Species: human

Top Publications

  1. pmc MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 60612, USA
    Biochem J 432:199-205. 2010
  2. doi Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors
    William D Tap
    University of California, Los Angeles Medical Center, Los Angeles, CA, USA
    J Clin Oncol 30:1849-56. 2012
  3. doi Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
    I Wolf
    Institute of Oncology Chaim Sheba Medical Center, Ramat Gan, Israel
    Oncogene 27:7094-105. 2008
  4. ncbi IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    Martin Holzenberger
    Institut National de la Santé et de la Recherche Médicale U515, Hopital Saint Antoine, 75571 Paris 12, France
    Nature 421:182-7. 2003
  5. pmc Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts
    Colette Galet
    Department of Urology, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Int J Mol Sci 14:13782-95. 2013
  6. ncbi Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src
    J E Peterson
    Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 271:31562-71. 1996
  7. doi SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor
    Bita Sehat
    1Department of Oncology and Pathology, Karolinska Institutet, Cancer Center Karolinska, R8 04, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Sci Signal 3:ra10. 2010
  8. doi β-Catenin/POU5F1/SOX2 transcription factor complex mediates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinoma
    Chuan Xu
    Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China
    Cancer Res 73:3181-9. 2013
  9. pmc Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth
    Deniz A Ucar
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA
    Cell Cycle 11:3250-9. 2012
  10. ncbi A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor
    T Ligensa
    Roche Diagnostics GmbH, Pharma Research, Nonnenwald 2, Penzberg 82372, Germany
    J Biol Chem 276:33419-27. 2001

Research Grants

  1. Mechanisms of Age-Related Skeletal Resistance to BMP-7 and IGF-I
    John C Lee; Fiscal Year: 2012
  2. Aging and IGF-1 Receptor in a three dimensional matrix
    Itay Bentov; Fiscal Year: 2013
  3. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2006
  4. B George Barisas; Fiscal Year: 2014
  5. Preliminary Evaluation of FDG-PET with anti-IGF-1R Targeted Therapy in GISTs
    Margaret von Mehren; Fiscal Year: 2013
  6. Shengli Ding; Fiscal Year: 2014
  7. Scott W Blume; Fiscal Year: 2015
  8. STEVEN ALAN ROSENZWEIG; Fiscal Year: 2016
  9. PET Imaging of KRAS2 Activation to Guide EGFR Targeting in Cancer Therapy
    Eric Wickstrom; Fiscal Year: 2013
  10. Andrei Thomas-Tikhonenko; Fiscal Year: 2014

Detail Information

Publications289 found, 100 shown here

  1. pmc MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
    Lu Jiang
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 60612, USA
    Biochem J 432:199-205. 2010
    ..Our results indicate that miR-7 plays an important role in TSCC and may serve as a novel therapeutic target for TSCC patients...
  2. doi Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors
    William D Tap
    University of California, Los Angeles Medical Center, Los Angeles, CA, USA
    J Clin Oncol 30:1849-56. 2012
    ..An open-label phase II study was conducted to evaluate the efficacy and safety of ganitumab monotherapy in patients with metastatic Ewing family tumors (EFT) or desmoplastic small round cell tumors (DSRCT)...
  3. doi Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
    I Wolf
    Institute of Oncology Chaim Sheba Medical Center, Ramat Gan, Israel
    Oncogene 27:7094-105. 2008
    ..These data suggest klotho as a potential tumor suppressor and identify it as an inhibitor of the IGF-1 pathway and activator of the FGF pathway in human breast cancer...
  4. ncbi IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    Martin Holzenberger
    Institut National de la Santé et de la Recherche Médicale U515, Hopital Saint Antoine, 75571 Paris 12, France
    Nature 421:182-7. 2003
    ..The Igf1r(+/-) mice display greater resistance to oxidative stress, a known determinant of ageing. These results indicate that the IGF-1 receptor may be a central regulator of mammalian lifespan...
  5. pmc Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts
    Colette Galet
    Department of Urology, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Int J Mol Sci 14:13782-95. 2013
    ..In conclusion, whereas ganitumab therapy modestly affected 22Rv1 tumor growth, combining IGF-1R blockade with calorie restriction resulted in a significant decrease in final tumor weight and improved metabolic profile. ..
  6. ncbi Src phosphorylates the insulin-like growth factor type I receptor on the autophosphorylation sites. Requirement for transformation by src
    J E Peterson
    Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 271:31562-71. 1996
    ..Thus, the Src kinase can substitute for the receptor kinase in phosphorylating and activating the IGF-I receptor, and this receptor phosphorylation and activation are essential for transformation by src...
  7. doi SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor
    Bita Sehat
    1Department of Oncology and Pathology, Karolinska Institutet, Cancer Center Karolinska, R8 04, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Sci Signal 3:ra10. 2010
    ..Thus, we demonstrate a SUMOylation-mediated mechanism of IGF-1R signaling that has potential implications for gene regulation...
  8. doi β-Catenin/POU5F1/SOX2 transcription factor complex mediates IGF-I receptor signaling and predicts poor prognosis in lung adenocarcinoma
    Chuan Xu
    Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China
    Cancer Res 73:3181-9. 2013
    ....
  9. pmc Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth
    Deniz A Ucar
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA
    Cell Cycle 11:3250-9. 2012
    ..Our data suggest that the FAK-IGF-1R protein interaction is an important target, and disruption of this interaction with a novel small molecule (INT2-31) has potential anti-neoplastic therapeutic effects in human melanoma...
  10. ncbi A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor
    T Ligensa
    Roche Diagnostics GmbH, Pharma Research, Nonnenwald 2, Penzberg 82372, Germany
    J Biol Chem 276:33419-27. 2001
    ..Furthermore, overexpression of IIP-1 resulted in an attenuation of migration of MCF-7 cells, which is one of the biological activities mediated by the IGF-1 signaling system...
  11. ncbi Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity
    Sanjeev Munshi
    Department of Structural Biology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 277:38797-802. 2002
    ..The ordered N terminus of one monomer approaches the active site of the other, suggesting that the juxtamembrane region of one molecule could come into close proximity to the active site of the other...
  12. ncbi Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin
    Radu Vasilcanu
    Department of Oncology Pathology, Cellular and Molecular Tumor Pathology, Cancer Center Karolinska, CCK R8 04, Karolinska Institutet, S 17176, Stockholm, Sweden
    Mol Pharmacol 73:930-9. 2008
    ..Thus, apart from inhibiting the receptor activity, PPP can induce IGF-1R ubiquitination and stimulate ERK in an Mdm2-dependent manner. This response could contribute to the apoptotic effect of PPP...
  13. pmc Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription
    Jeremie Boucher
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 285:17235-45. 2010
    ..Thus, IR and IGF1R act as identical portals to the regulation of gene expression, with differences between insulin and IGF-1 effects due to a modulation of the amplitude of the signal created by the specific ligand-receptor interaction...
  14. ncbi Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells
    Jing Fang
    The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Shanghai 200031, China
    Carcinogenesis 28:713-23. 2007
    ..Immunoblotting of the extracts of tumor tissues showed that luteolin inhibited IGF-1R/AKT signaling. Our results provide a new insight into the mechanisms that luteolin is against cancer cells...
  15. pmc Functionally significant insulin-like growth factor I receptor mutations in centenarians
    Yousin Suh
    Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:3438-42. 2008
    ..centenarians relative to controls that are associated with high serum IGFI levels and reduced activity of the IGFIR as measured in transformed lymphocytes...
  16. ncbi IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation
    M Jennifer Abuzzahab
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    N Engl J Med 349:2211-22. 2003
    ..We postulated that mutations in the gene for the insulin-like growth factor I receptor (IGF-IR) might underlie some cases of prenatal and postnatal growth failure...
  17. ncbi {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase
    Leonard Girnita
    Department of Oncology and Pathology, Division of Cellular and Molecular Tumor Pathology, Cancer Center Karolinska, R8 04, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Biol Chem 280:24412-9. 2005
    ..To our knowledge this is the first study demonstrating a defined molecular role of beta-arrestin with direct relevance to cell growth and cancer...
  18. doi The strength of small: improved targeting of insulin-like growth factor-1 receptor (IGF-1R) with F(ab')₂-R1507 fragments in Ewing sarcomas
    Emmy D G Fleuren
    Department of Medical Oncology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Cancer 49:2851-8. 2013
    ..To investigate whether F(ab')₂-fragments of the monoclonal Insulin-like Growth Factor-1 Receptor (IGF-1R) antibody R1507 (F(ab')₂-R1507) can successfully target IGF-1R in Ewing sarcomas (ES)...
  19. ncbi Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein
    B L Seely
    Department of Medicine, University of California at San Diego, La Jolla 92093, USA
    J Biol Chem 270:19151-7. 1995
    ..p85, Syp, and GAP are potential modulators of IGF-I receptor signal transduction...
  20. doi Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets
    Caroline Gest
    Laboratoire M E R C I EA 3829, Faculte de Medecine et de Pharmacie, Universite de Rouen, Rouen, France
    Cancer Lett 317:207-17. 2012
    ..Among 10 agents tested for their ability to decrease cancer cell aggressivity using these two models, inhibitors of Stat3, IGF-IR and Rho GTPase were found to be the most promising...
  21. ncbi Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor
    Tracy Criswell
    Department of Radiation Oncology and Program in Molecular and Cellular Basis of Disease, Laboratory of Molecular Stress Responses, Case Comprehensive Cancer Center, Cleveland, Ohio 44106 7285, USA
    J Biol Chem 280:14212-21. 2005
    ..Thus, ionizing radiation exposure causes stress-induced activation of IGF-1R-Src-Mek-Erk-Egr-1 signaling that regulates the sCLU pro-survival cascade pathway, important for radiation resistance in cancer therapy...
  22. ncbi Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer
    Rive Sarfstein
    Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell Endocrinol 252:241-6. 2006
    ..This review highlights selected examples of tumor suppressors, including BRCA1, p53, and WT1, whose mechanism of action involves regulation of IGF-IR gene expression...
  23. pmc Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231
    Desma M Grice
    School of Pharmacy, University of Queensland, Brisbane 4072, Australia
    J Biol Chem 285:37458-66. 2010
    ..Inhibitors of SPCA1 may offer an alternative strategy to direct inhibitors of IGF1R and attenuate the processing of other proprotein convertase substrates important in basal breast cancers...
  24. doi Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness
    X He
    Department of Urology, University of Rochester Medical Center, Rochester, NY, USA
    Oncogene 30:535-47. 2011
    ..Our data indicate that RACK1 serves as a direct mediator between loss of pVHL function and enhanced IGF-IR signaling pathway in RCC...
  25. pmc The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptor
    Cecilia A Fernandez
    Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Biol Chem 285:41886-95. 2010
    ....
  26. doi Insulin-like growth factor receptor-1 (IGF-1R) expression in normal breast, proliferative breast lesions, and breast carcinoma
    Rohit Bhargava
    Department of Pathology, Magee Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Appl Immunohistochem Mol Morphol 19:218-25. 2011
    ..The consistent presence of IGF-1R in ER+ tumors may explain the lower response rate to neoadjuvant chemotherapy in luminal tumors...
  27. pmc Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
    Yinghui Zhang
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands
    Breast Cancer Res 13:R52. 2011
    ..In the present study, we sought to elucidate whether antiestrogen resistance is induced directly by IGF-1R signaling in response to its ligand IGF-1 stimulation...
  28. doi Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma
    Yin He Wang
    Department of Orthopaedic Surgery, The Affiliated Drum Tower Hospital of Nanjing, University Medical School, Nanjing, Jaingsu, P R China
    J Surg Oncol 105:235-43. 2012
    ..The aim of this study was to investigate the association of insulin-like growth factor-1 receptor (IGF-1R) with metastasis and prognosis of osteosarcoma patients...
  29. ncbi Substrate-bound insulin-like growth factor (IGF)-I-IGF binding protein-vitronectin-stimulated breast cell migration is enhanced by coactivation of the phosphatidylinositide 3-Kinase/AKT pathway by alphav-integrins and the IGF-I receptor
    Brett G Hollier
    Tissue Repair and Regeneration ProgramInstitute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Queensland 4059, Australia
    Endocrinology 149:1075-90. 2008
    ....
  30. pmc High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling
    Hind Medyouf
    Terry Fox Laboratory Department of Pathology, BC Cancer Agency, Vancouver, BC, V52 1L3 Canada
    J Exp Med 208:1809-22. 2011
    ....
  31. ncbi Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells
    Chareeporn Akekawatchai
    School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia, Australia, 5005
    J Biol Chem 280:39701-8. 2005
    ..Based on our findings, we propose that CXCR4 constitutively forms a complex with IGF-1R in MDA-MB-231 cells, and that this interaction allows IGF-1 to activate migrational signaling pathways through CXCR4, G(i)alpha2 and Gbeta...
  32. ncbi Caveolin-1 up-regulates IGF-I receptor gene transcription in breast cancer cells via Sp1- and p53-dependent pathways
    Chen Glait
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Exp Cell Res 312:3899-908. 2006
    ..In summary, we identified the IGF-IR gene as a downstream target for Cav-1 action in breast cancer cells...
  33. ncbi Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells
    John G Shelton
    Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA
    Cell Cycle 3:372-9. 2004
    ..These results demonstrate that the PI3K/Akt and Raf/MEK/ERK pathways are intimately involved in IGF-1R-mediated cell cycle progression and prevention of apoptosis in hematopoietic cells...
  34. ncbi Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells
    Todd W Bauer
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:1676-82. 2006
    ..Elucidation of the signaling pathways that contribute to tumor progression and metastasis should provide a foundation for the development of targeted therapies for pancreatic carcinoma...
  35. ncbi Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system
    S Tartare-Deckert
    INSERM U145, Nice, France
    J Biol Chem 270:23456-60. 1995
    ..Finally, our data highlight the crucial role of the juxtamembrane domain in signaling by both the IR and the IGF-IR...
  36. pmc HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy
    Yan Xu
    Dorrance H Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:7070-5. 2004
    ..These analyses suggest molecular mechanisms for the induction of apoptosis relating to the exposure of viral and host cell factors and rationally designed approaches toward neuroprotection...
  37. ncbi Expression of insulin-like growth factor-1 receptor in local and metastatic prostate cancer
    Charles J Ryan
    Department of Medicine, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    Urol Oncol 25:134-40. 2007
    ..Despite this targeting, there are conflicting data on the presence of this receptor in human tumor samples, largely because of differences in technique...
  38. pmc Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma
    Brenda M Birmann
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:282-8. 2009
    ..Nonetheless, the data are consistent with the hypothesis that IGF-1- and IL-6-related gene variation influences susceptibility to multiple myeloma and warrant confirmation in larger populations...
  39. pmc The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling
    Jun Saegusa
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    J Biol Chem 284:24106-14. 2009
    ....
  40. pmc Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small-cell lung cancer (NSCLC) patients
    F Cappuzzo
    Department of Oncology Hematology, Istituto Clinico Humanitas Istituto di Ricerca a Carattere Scientifico IRCCS, Rozzano
    Ann Oncol 21:562-7. 2010
    ..Patients exposed to anti-epidermal growth factor receptor (EGFR) agents were excluded. IGF1R expression was evaluated by immunohistochemistry in tissue microarray sections...
  41. ncbi Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines
    Garrett Brady
    Deprtment of Oral and Maxillofacial Surgery, Leeds Dental Institute, Clarendon Way, Leeds LS2 9LU, UK
    Int J Oncol 31:875-81. 2007
    ..Taken together, these studies suggest that autocrine production of IGF-2, together with over-expression of IGF-1R, may be important components controlling the proliferation of oral carcinoma cells...
  42. doi Expression of IGF1R is associated with tumor differentiation and survival in patients with lung adenocarcinoma
    Ryutaro Kikuchi
    Department of Thoracic Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Ann Surg Oncol 19:S412-20. 2012
    ..The insulin-like growth factor 1 receptor (IGF1R) is widely expressed in normal tissues and many malignancies in humans. We investigated the clinical significance of the expression of the IGF1R gene in human lung adenocarcinoma...
  43. pmc Transgenic IGF-IR overexpression induces mammary tumors with basal-like characteristics, whereas IGF-IR-independent mammary tumors express a claudin-low gene signature
    S E Franks
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Oncogene 31:3298-309. 2012
    ..Therefore, this approach was utilized to classify the mammary tumors that develop in MTB-IGFIR transgenic mice...
  44. ncbi A redox-sensitive pathway mediates oxidized LDL-induced downregulation of insulin-like growth factor-1 receptor
    Yusuke Higashi
    Section of Cardiology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    J Lipid Res 46:1266-77. 2005
    ..In conclusion, our data demonstrate that OxLDL downregulates IGF-1R via redox-sensitive pathways that are distinct from OxLDL signaling through MAPK- and PPARgamma-involved pathways but may involve a CD36-dependent mechanism...
  45. doi Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor
    Sandra Andersson
    Karolinska Institute, Department of Oncology and Pathology, Karolinska Hospital, Stockholm, Sweden
    Biochem Biophys Res Commun 387:36-41. 2009
    ..Furthermore, the stability of IGF-1R was decreased upon FAK siRNA or inactivation. Taken together, our data suggest a role for FAK in phosphorylation, signaling and stability of the IGF-1R...
  46. doi The expression and role of hybrid insulin/insulin-like growth factor receptor type 1 in endometrial carcinoma cells
    Guo Zhang
    Department of Gynecology, Peking University People s Hospital, No 11 Xi Zhi Men South Street, Xi Cheng District, Beijing, China
    Cancer Genet Cytogenet 200:140-8. 2010
    ..Hybrid-R, which is present in endometrial carcinoma cells, may have an important role in mediating IGF- and insulin-induced cell growth and in preventing apoptosis...
  47. pmc Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-α and -β via the IGF-1 and the insulin receptors in breast cancer cells
    A E Richardson
    School of Medicine, Center for Health Disparities and Molecular Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Growth Factors 29:82-93. 2011
    ..This novel mechanism of IGF-2 synergistic cross-talk signaling with ER-α and ER-β can promote estrogen-independent BC progression and provide new therapeutic targets for the treatment of BC patients...
  48. ncbi Insulin-like growth factor (IGF) binding protein-3 interacts with the type 1 IGF receptor, reducing the affinity of the receptor for its ligand: an alternative mechanism in the regulation of IGF action
    S Mohseni-Zadeh
    Institut National de la Sante et de la Recherche Medicale, U 142, Hopital Saint Antoine, Paris, France
    Endocrinology 138:5645-8. 1997
    ..we used a fibroblast cell line to investigate the possibility of an interaction with the type 1 IGF receptor (IGFR-1)...
  49. ncbi Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the phosphatidylinositol 3 kinase/Akt signaling pathway
    Yangxin Li
    Tulane University Medical Center, New Orleans, LA 70112 2699, USA
    Arterioscler Thromb Vasc Biol 23:2178-84. 2003
    ..Because oxidized LDL is potentially important for the depletion of vascular smooth muscle cells contributing to plaque destabilization, we studied the role of IGF-1 in oxidized LDL-induced apoptosis...
  50. ncbi Interaction of 14-3-3 proteins with the insulin-like growth factor I receptor (IGFIR): evidence for a role of 14-3-3 proteins in IGFIR signaling
    Susan L Spence
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 312:1060-6. 2003
    ..yeast two-hybrid findings to show that 14-3-3beta also interacts with the insulin-like growth factor I receptor (IGFIR) in mammalian cells overexpressing both proteins and that the interaction involves serine 1283 and is dependent on ..
  51. ncbi Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells
    Stephana Carelli
    Laboratory of Pharmacology, Department of Medicine, Surgery, and Dentistry, University of Milan, Milan, Italy
    J Cell Physiol 208:354-62. 2006
    ..Such a different route for IGF-IR processing might take place sometime during development, since both proteasome and lysosome pathways are active in fetal lung human fibroblasts, IMR90 cells...
  52. ncbi Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3)
    H Kato
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:2655-61. 1993
    ..Additionally, the effects of alpha IR-3 also require tyrosine kinase activity...
  53. ncbi JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3
    Ajay Yadav
    National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Biol Chem 280:31830-40. 2005
    ..We have subsequently shown that SOCS-3 overexpression, on one hand, leads to neuroblastoma cell death and on the other hand leads to primary cell differentiation, indicating the involvement of SOCS-3 in cell survival and differentiation...
  54. pmc The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer
    Joanna Lisztwan
    Novartis Institutes of Biomedical Research Basel, Oncology Research, Klybeckstrasse 141, CH 4057, Basel, Switzerland
    Breast Cancer Res 10:R56. 2008
    ....
  55. doi Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer
    John S P Yuen
    Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Headington, Oxford, United Kingdom
    Mol Cancer Ther 8:1448-59. 2009
    ....
  56. pmc The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival
    D Sachdev
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Oncogene 29:251-62. 2010
    ..The multiple phenotypes regulated by IGF1R must be considered during development of this therapeutic strategy as inhibition of metastasis independent of inhibition of tumor growth is not easily assessed in phase II clinical trials...
  57. ncbi 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner
    A Craparo
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 272:11663-9. 1997
    ..interaction, we show that the epsilon isoform of 14-3-3 interacts with the insulin-like growth factor I receptor (IGFIR) and with insulin receptor substrate I (IRS-1), but not with the insulin receptor (IR)...
  58. ncbi PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells
    Hong Zhao
    Diabetes Branch, NIDDK, National Institute of Health, Room 8D12, Bldg 10, Bethesda, MD 20892 1758, USA
    Oncogene 23:786-94. 2004
    ..These results have important implications for understanding the roles of PTEN and the IGF-IR in prostate cancer cell tumorigenesis...
  59. ncbi Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotop
    Sven A Lang
    Department of Surgery, University of Regensburg Medical Center, Regensburg, Germany
    Clin Cancer Res 13:6459-68. 2007
    ....
  60. ncbi Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    Arnab Chakravarti
    Department of Radiation Oncology, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 62:200-7. 2002
    ..The resistant GBM(R) cell line demonstrated an up-regulation of insulin-like growth factor receptor I (IGFR-I) levels on AG1478 administration...
  61. ncbi Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach
    Elfar Ulfarsson
    Department of Neurosurgery, Institution for Surgical Sciences, Stockholm, Sweden
    Clin Cancer Res 11:4674-80. 2005
    ....
  62. ncbi Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor
    B R Dey
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Gene 209:175-83. 1998
    ..to identify proteins that interact with the intracellular domain of the insulin-like growth factor-I receptor (IGFIR)...
  63. ncbi Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology
    A A Butler
    Diabetes Branch, National Institutes of Health, Bethesda, MD 20892 1770, USA
    Comp Biochem Physiol B Biochem Mol Biol 121:19-26. 1998
    ..This review outlines some of the signalling pathways believed to be important in converting IGF-IR activation into changes in cell behavior and metabolism...
  64. pmc Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Biochem J 368:875-84. 2002
    ....
  65. ncbi The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway
    Julie R McMullen
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:4782-93. 2004
    ..This study suggests that targeting the cardiac IGF1R-PI3K(p110alpha) pathway could be a potential therapeutic strategy for the treatment of heart failure...
  66. ncbi Prostate cancer risk in relation to selected genetic polymorphisms in insulin-like growth factor-I, insulin-like growth factor binding protein-3, and insulin-like growth factor-I receptor
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, WA, USA
    Cancer Epidemiol Biomarkers Prev 15:2461-6. 2006
    ..Our observation that men who do not carry two copies of the IGF-IR (AGG)7 allele are at increased risk of prostate cancer merits further investigation...
  67. pmc Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity
    A Ullrich
    EMBO J 5:2503-12. 1986
    ....
  68. ncbi Grb10: A new substrate of the insulin-like growth factor I receptor
    A Morrione
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 56:3165-7. 1996
    ..Grb10 coprecipitates with the IGF-IR in cell lysates and is probably involved in the regulation of its activity...
  69. ncbi C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor
    C Arbet-Engels
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 274:5422-8. 1999
    ..The results suggest that c-Src and CSK are involved in IGF-IR and IR signaling and that the interaction of CSK with the IGF-IR may play a role in the decrease in c-Src activity following IGF-I stimulation...
  70. ncbi Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain
    W Lopaczynski
    Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Biochem Biophys Res Commun 279:955-60. 2000
    ..We conclude that the IGF-I receptor tyrosine kinase is not a dual-specificity kinase and that autophosphorylation of the beta subunit is by a trans mechanism...
  71. ncbi Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer
    Niels Reinmuth
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Lab Invest 82:1377-89. 2002
    ..These studies demonstrate that the IGF-IR plays an important role in multiple mechanisms that mediate the growth, angiogenesis, and metastasis of human colon cancer. IGF-IR is a valid target for the therapy of human colon cancer...
  72. pmc Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor
    Leonard Girnita
    Department of Oncology and Pathology, Division of Cellular and Molecular Tumor Pathology, Cancer Center Karolinska, R8 04, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:8247-52. 2003
    ..Consequently, by sequestering Mdm2 in the cell nuclei, the level of p53 may indirectly influence the expression of IGF-1R. This role of Mdm2 and p53 represents an unexpected mechanism for the regulation of IGF-1R and cell growth...
  73. pmc The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane
    Robert X Song
    Department of Internal Medicine and Biomolecular Research Facility, University of Virginia School of Medicine, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 101:2076-81. 2004
    ..Together, our results demonstrate that Shc and IGF-1R serve as key elements in the translocation of ERalpha to the cell membrane and in the facilitation of ERalpha-mediated rapid E2 action...
  74. ncbi Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling
    Luigi Laviola
    Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Endocrinology 146:1498-505. 2005
    ..The observed abnormalities in IGF-I signaling may contribute to altered fetal growth and development in human IUGR...
  75. ncbi Association of insulin-like growth factor-1 receptor polymorphism in dementia
    J Garcia
    Department of Neuroscience and Locomotion, Division of Geriatric Medicine, Linkoping University, Linkoping, Sweden
    Dement Geriatr Cogn Disord 22:439-44. 2006
    ..5, CI 95% 0.99-2.2, p = 0.054). Our results suggest that the A allele of IGF-1R may be involved in the pathogenesis of VaD in females...
  76. ncbi Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib
    Floriana Morgillo
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:10100-11. 2006
    ..Our data suggest that enhanced synthesis of survivin protein mediated by the IGFR/EGFR heterodimer counteracts the antitumor action of erlotinib, indicating the needs of integration of IGF-IR-..
  77. ncbi Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations
    Sharon Maor
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Cancer Lett 257:236-43. 2007
    ..In conclusion, our data suggests that the IGF-IR gene is a physiologically relevant downstream target for BRCA1 action...
  78. doi Insulin-like growth factor-1 receptor polymorphism and ischemic stroke: a case-control study in Chinese population
    J Cheng
    Department of Molecular Biology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China
    Acta Neurol Scand 118:333-8. 2008
    ..Whether there is any association of genetic variation in IGF-1R gene with ischemic stroke (IS) is presently unknown...
  79. ncbi Knockdown of insulin-like growth factor 1 receptor enhances chemosensitivity to cisplatin in human lung adenocarcinoma A549 cells
    Aiqiang Dong
    Department of Cardiothoracic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
    Acta Biochim Biophys Sin (Shanghai) 40:497-504. 2008
    ..Suppression of IGF1R gene expression by shRNA enhances the chemosensitivity of A549 cells to DDP both in vitro and in vivo, indicating the therapeutic potential of RNA interference as a method for gene therapy in treating lung cancer...
  80. doi MVP expression is related to IGF1-R in cervical carcinoma patients treated by radiochemotherapy
    Marta Lloret
    Radiation Oncology, Dr Negrin University Hospital, Las Palmas de Gran Canaria, Spain
    Gynecol Oncol 110:304-7. 2008
    ..In addition the relation to IGF-1R expression in this cohort of patients will be explored...
  81. doi Polymorphisms in the IGF1 signalling pathway including the myostatin gene are associated with left ventricular mass in male athletes
    Ruth Jessica Karlowatz
    Institute of Human Genetics, University of Saarland IGD Saar GmbH, Homburg Saar, Germany
    Br J Sports Med 45:36-41. 2011
    ..Genetic polymorphisms in the cardiological relevant insulin-like growth factor 1 (IGF1) signalling pathway seem to have an essential influence on the extent of physiological hypertrophy...
  82. doi Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway
    Gaspare La Rocca
    Department of Cancer Biology at Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA 19107, USA
    J Cell Physiol 220:485-91. 2009
    ..These and other results, taken together, indicate that down-regulation of IRS-1 plays a significant role in the tumor suppressor activity of miR145...
  83. doi Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin
    Xiaoping Huang
    Departments of Pathology and Obstetrics and Gynecology, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Cancer Res 70:1204-14. 2010
    ..On the basis of our results, we propose that trastuzumab resistance in breast cancer might be overcome by therapeutic strategies that jointly target erbB3, erbB2, and IGF-IR...
  84. pmc Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
    S Eliasz
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Oncogene 29:2488-98. 2010
    ..Our data provide a mechanistic explanation for Notch-1-mediated pro-survival function in hypoxic ACL tumor microenvironment. The results identify additional targets that may synergize with Notch-1 inhibition for ACL treatment...
  85. ncbi Prognostic significance of insulin growth factor-I receptor and insulin growth factor binding protein-3 expression in primary breast cancer
    Jun H Kim
    Departments of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110 746, Korea
    Oncol Rep 23:989-95. 2010
    ..026, HR=0.462, 95% CI=0.234-0.913) in the IGF-IR-positive group. IGF-IR expression in primary breast cancer is an independent favorable prognostic factor. IGFBP-3 expression in breast cancer is associated with poor outcome...
  86. pmc MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R
    Galya Lerman
    Laboratory of Molecular Cell Biology, Center for Cancer Research and Department of Internal Medicine C, Sheba Medical Center, Tel Hashomer, Israel
    PLoS ONE 6:e20916. 2011
    ..Here, we describe the differential expression of miRNAs in psoriatic involved and uninvolved skin as compared to normal skin, revealing an additional aspect of this complex disorder...
  87. pmc Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model
    Tiphanie Durfort
    Institut National de la Santé et de la Recherche Médicale INSERM U565, Paris, France
    PLoS ONE 7:e29213. 2012
    ..Interestingly, our work also suggests that crosstalk between IGF-I axis and antitumor immune response can mobilize proinflammatory cytokines...
  88. doi MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor
    X Zhao
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi an, China
    Oncogene 32:1363-72. 2013
    ..The present study provides insight into the specific biological behavior of miR-7 in EMT and tumor metastasis. Targeting this novel miR-7/IGF1R/Snail axis would be helpful as a therapeutic approach to block GC metastasis...
  89. ncbi Insulin-like growth factor I receptor gene structure
    A M Abbott
    Elliot P Joslin Research Laboratory, Joslin Diabetes Center, Boston, MA 02215
    J Biol Chem 267:10759-63. 1992
    ..We have isolated and characterized human genomic DNA clones containing the entire coding sequence of the IGF I receptor. Results of restriction analysis and sequencing of multiple overlapping clones were consistent with the ..
  90. pmc The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site
    T Kjeldsen
    Molecular Genetics, Bioscience Corporate Research, Bagsvaerd, Denmark
    Proc Natl Acad Sci U S A 88:4404-8. 1991
    ..e., the sequences that discriminate between insulin and IGF-I) reside in different regions of a binding site with common features present in both receptors...
  91. ncbi Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2
    W He
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Biol Chem 271:11641-5. 1996
    ..Our findings suggest the existence of a previously unidentified phosphotyrosine-dependent binding domain within the central region of IRS-2...
  92. pmc Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting
    E M Bailyes
    University of Cambridge, Department of Clinical Biochemistry, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, U K
    Biochem J 327:209-15. 1997
    The insulin receptor (IR) and type 1 insulin-like growth factor (IGF-I) receptor (IGFR) are both widely expressed in mammalian tissues, and are known to be capable of heteromeric assembly as insulin/IGF hybrid receptors, in addition to ..
  93. ncbi Expression of the insulin-like growth factors and their receptors in term placentas: a comparison between normal and IUGR births
    S N Abu-Amero
    Molecular Biology Laboratory for Fetal Development, Queen Charlotte s and Chelsea Hospital, London, England
    Mol Reprod Dev 49:229-35. 1998
    ..The increase in the transcription of IGF2 and IGF1R in IUGR term placentas may represent a counter regulatory mechanism in response to the growth retardation...
  94. ncbi Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling
    B Kim
    Neuroscience Program and Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 273:34543-50. 1998
    ....
  95. ncbi Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway
    S Kahlert
    Medizinische Poliklinik and the Institut für Physiologie II, University of Bonn, 53111 Bonn, Germany
    J Biol Chem 275:18447-53. 2000
    ..Taken together, these data demonstrate that ligand bound estrogen receptor alpha is required for rapid activation of the IGF-1R signaling cascade...
  96. ncbi Structure and autoregulation of the insulin-like growth factor 1 receptor kinase
    S Favelyukis
    Department of Physiology and Biophysics, School of Medicine State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Nat Struct Biol 8:1058-63. 2001
    ..Although the nucleotide binding cleft is conserved between IGF1RK and the insulin receptor kinase, sequence differences in the nearby interlobe linker could potentially be exploited for anticancer drug design...
  97. ncbi Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease
    Giles O Hellawell
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Cancer Res 62:2942-50. 2002
    ..These findings challenge earlier reports of IGF1R down-regulation in metastatic disease and reinforce the importance of the IGF1R in prostate cancer biology...
  98. ncbi Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
    Giuseppe Pandini
    Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, University of Catania, Ospedale Garibaldi, 95123 Catania, Italy
    J Biol Chem 277:39684-95. 2002
    ..The relative abundance of IR isoforms therefore affects IGF system activation through Hybrid-Rs, with important consequences for tissue-specific responses to both insulin and IGFs...
  99. ncbi Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling
    Yu Tzu Tai
    The Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Res 63:5850-8. 2003
    ..Moreover, they define the functional association of IGF-IR and beta1 integrin in mediating MM cell homing, providing the preclinical rationale for novel treatment strategies targeting IGF-I/IGF-IR in MM...
  100. ncbi Expression of the insulin-like growth factor-I receptor in primary breast cancer and lymph node metastases: correlations with estrogen receptors alpha and beta
    M Koda
    Department of Clinical Pathology, Medical University of Bialystok, Poland
    Horm Metab Res 35:794-801. 2003
    ..The results suggest that IGF-IR could become a viable pharmaceutical target in breast cancer therapy, but such therapy should be based on IGF-IR assessment in primary tumor and metastasis in each potential patient...
  101. ncbi Combined effects of tamoxifen and a chimeric humanized single chain antibody against the type I IGF receptor on breast tumor growth in vivo
    J J Ye
    Department of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Horm Metab Res 35:836-42. 2003
    ..scFv-Fc treatment down-regulated IGF-IR which appears to contribute to tumor growth inhibition. This study provides evidence that simultaneous targeting of IGF-IR and the estrogen receptor may enhance the therapeutic effect...

Research Grants85

  1. Mechanisms of Age-Related Skeletal Resistance to BMP-7 and IGF-I
    John C Lee; Fiscal Year: 2012
    ..The goal of the current study is to provide a molecular basis for the development of novel therapeutic agents that will treat age related osteoporosis by activating signal transduction pathways used by bone anabolic agents. ..
  2. Aging and IGF-1 Receptor in a three dimensional matrix
    Itay Bentov; Fiscal Year: 2013
    ..This is significant because understanding the basis of age-associated delayed wound healing could potentially offer novel therapeutic modalities. ..
  3. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2006
    ..abstract_text> ..
  4. B George Barisas; Fiscal Year: 2014
    ....
  5. Preliminary Evaluation of FDG-PET with anti-IGF-1R Targeted Therapy in GISTs
    Margaret von Mehren; Fiscal Year: 2013
    ....
  6. Shengli Ding; Fiscal Year: 2014
    ..Our findings will advance mechanistic understanding of the roles of IGF1R and IR in intestinal growth, stem cells and spontaneous or obesity-associated CRC ..
  7. Scott W Blume; Fiscal Year: 2015
    ....
  8. STEVEN ALAN ROSENZWEIG; Fiscal Year: 2016
    ..This will lead to the development of novel strategies and therapeutic agents aimed at reducing the tumorigenic and metastatic effects of the IGF and VEGF pathways in HNSCC. ..
  9. PET Imaging of KRAS2 Activation to Guide EGFR Targeting in Cancer Therapy
    Eric Wickstrom; Fiscal Year: 2013
    ....
  10. Andrei Thomas-Tikhonenko; Fiscal Year: 2014
    ..The main impact of this study is that it would allow prospective stratification of patients enrolled in clinical trials of IGF1R inhibitors nd more robust responses to these drugs, ushering in the era of miR pharmacogenomics. ..
  11. Alan C Rapraeger; Fiscal Year: 2014
    ..Synstatin will be tested for its efficacy on the myeloma tumor and on the tumor microenvironment. ..
  12. Shengli Ding; Fiscal Year: 2016
    ..Findings will fundamentally advance our knowledge of the effects of aging on IESC and identify new mechanisms, biomarkers, and potential therapeutic targets to better monitor and promote successful IESC and intestinal aging. ..
  13. Insulin Receptor in Intestinal Growth, Tumorigenesis, Aging, and Obesity
    SARAH BORTVEDT; Fiscal Year: 2012
    ..This knowledge is critical to improved CRC prevention, detection, and treatment in the face of an expanding aging population, the obesity pandemic, and the rising cost of healthcare. ..
  14. IGF1R: A candidate oncogene in pediatric high grade gliomas
    Claudia P Miller; Fiscal Year: 2012
    ..There is a need for improved understanding of pediatric HGG to identify relevant therapeutic targets for kids. ..
  15. TARGETING THE IGF SYSTEM IN BREAST CANCER
    Douglas Yee; Fiscal Year: 2012
    ..This proposal will explore the molecular pathways used by this system to stimulate cancer cells. The long-term goal is to develop better tools to predict which patients will benefit from anti-IGF therapy. ..
  16. Calcium-Sensing Receptors and Growth Plate Development
    Wenhan Chang; Fiscal Year: 2012
    ..This proposal will investigate how Ca2+ acts on these chondrocytes and will help us understand how to treat disorders of growth and poor mineralization like rickets. ..
  17. Jennifer D Black; Fiscal Year: 2016
    ....
  18. Zhe Li; Fiscal Year: 2015
    ..It is expected that these studies will significantly enhance our understanding of the role of IGF/IGF1R signaling in blood development, and of how its activation contributes to leukemia in a cellular context-dependent manner. ..
  19. IGF-I Signaling and Aging
    Martin L Adamo; Fiscal Year: 2011
    ..abstract_text> ..
  20. Growth Factor-Induced Resistance to Targeted Therapy in Oral Cavity Cancer
    Mark J Jameson; Fiscal Year: 2013
    ..The project will focus on determining the occurrence of IGFIR-induced resistance to EGFR antagonists in human tumor specimens and cell lines, and then will identify the pivotal ..
  21. Xiaolin Zi; Fiscal Year: 2014
    ..Our studies will determine if the proposed molecular target is correct, and may point to other enzymes and cytokines as potential targets of lycopene. ..
  22. Michael L Cunningham; Fiscal Year: 2016
    ..There is an incomplete understanding of the causes of craniosynostosis and we lack experimental models. The development of these resources will improve clinical care, design biologically based therapies, and pursue primary prevention. ..
  23. Flaxseed vs. aromatase inhibitors: breast tumor characteristics and prognosis
    Susan McCann; Fiscal Year: 2009
    ..interaction between flaxseed and AI on tumor expression of Ki-67, caspase, ERa, ER[unreadable], PgR, HER2, IGF1, IGFIR. The pre-surgical setting offers a unique opportunity to rapidly obtain information on intervention related ..
  24. Oncogenic role of PIK3CA hotspot mutations
    RAMON E PARSONS; Fiscal Year: 2013
    ..abstract_text> ..
  25. GENETICS OF GROWTH: ROLES OF IGFS AND GROWTH HORMONE
    Argiris Efstratiadis; Fiscal Year: 1999
    ....
  26. THE INSULIN-LIKE GROWTH FACTOR AXIS IN OSTEOARTHRITIS
    Teresa Morales; Fiscal Year: 2006
    ..putative receptors); (2) changes in the levels and synthesis of the components of the IGF axis (IGFBPs, IGFs, IGFIR), as well as in the putative IGFBP-3 anchor, fibronectin, during OA; and (3) the function of the IGFBPs, as ..
  27. Hsp90 as a Target for the Treatment of Childhood Cancer
    Rochelle Bagatell; Fiscal Year: 2010
    ..Upon completion of the award period, Dr. Bagatell will be well prepared to move forward as an independent investigator. ..
  28. Dietary lignan effects on hormone, growth, and signaling factors in breast tumors
    Susan McCann; Fiscal Year: 2009
    ..factor and signaling pathway protein expression (ERa, ER[unreadable], ERa: ER[unreadable] ratio, PgR, HER2, IGF1, IGFIR) associated with dietary lignan intakes;and 3) examine the association of breast tumor subtype (luminal A, luminal ..
  29. GLENN THOMAS KONOPASKE; Fiscal Year: 2015
    ....
  30. HER-2/IGF-IR cross-talk and Herceptin resistance
    Rita Nahta; Fiscal Year: 2010
    ..central hypothesis of this application is that Herceptin resistance is mediated by increased binding of HER-2 to IGFIR with subsequent degradation of p27kip1 in breast cancer cells...
  31. The Molecular Actions of Imatinib Mesylate in GISTs
    Margaret von Mehren; Fiscal Year: 2013
    ..In Aim 3 we will test the novel therapeutic combination of imatinib and an anti-IGF1R targeted antibody in the treatment of patients with advanced GIST. ..
  32. MTOR AS A THERAPEUTIC TARGET IN PEDIATRIC SOLID TUMORS
    Peter J Houghton; Fiscal Year: 2011
    ..The overall objective is to test therapeutic strategies in appropriate xenograft models, and use the results for design of clinical protocols. ..
  33. Nanotube Antibody Arrays for Profiling Circulating Diseased Cells
    Balaji Panchapakesan; Fiscal Year: 2011
    ..Based on the sensor arrays, a device will be developed that will be used in detecting and profiling circulating breast cancer cells in blood. This new technology will be compared against standard immunoassays such as ELISA. ..
  34. Roland L Dunbrack; Fiscal Year: 2016
    ..Several experimental approaches will be utilized and further structural analysis of the autophosphorylation interfaces will be performed. ..
  35. Functions of EPH Receptors and Ephrins in Neuroblastoma
    Naohiko Ikegaki; Fiscal Year: 2005
    ..Results of this study would reveal novel mechanisms by which EPHB6 and ephrin-B ligands restrict growth, angiogenesis and metastasis of NB. Such knowledge may help develop an innovative and effective treatment for unfavorable NB. ..
  36. MOLECULAR GENETIC ALTERATIONS IN MALIGNANT MESOTHELIOMA
    JOSEPH TESTA; Fiscal Year: 2006
    ..Overall, these studies are expected to provide insights regarding mechanisms by which specific TSGs contribute to the pathogenesis of MM and delineate potential avenues for therapeutic intervention. ..
  37. MECHANISMS REGULATING UTERINE MORPHOGENESIS
    Thomas Spencer; Fiscal Year: 2004
    ....
  38. Cbfa1 and Prostate Cancer Bone Metastases
    Nora Navone; Fiscal Year: 2007
    ..3) To study the role of the IGF-I and Cbfal signaling pathways in the growth and survival of PCa cells in our in vivo (immunodeficient cre/IoxP-Igf1r transgenic mice) and in vitro model systems. ..
  39. NEOPLASTIC COMPLICATIONS IN INFLAMMATORY BOWEL DISEASE
    Stephen Meltzer; Fiscal Year: 2001
    ..2. To assess MI at coding region targets in a large cohort of UCAn patients. 2.a. To assess inactivation of IGFIR and TGF-beta1RII by coding region MI, loss of heterozygosity, or diminished IGFIIR or TGF-betaRII expression at ..
  40. MOLECULAR THERAPEUTICS OF CANCER
    David Carbone; Fiscal Year: 2003
    ..This award would allow me additional time to further patient-oriented research at the, Vanderbilt Cancer Center and time to mentor fellow and junior faculty patient-oriented research projects. ..
  41. IGF AXIS IN PROSTATE CANCER--TRANSGENIC STUDY
    Norman Greenberg; Fiscal Year: 2003
    ..abstract_text> ..
  42. IGFIR IN HUMAN GI TUMORS
    Stephen Meltzer; Fiscal Year: 2000
    DESCRIPTION: IGFIR and IGFII are antiapoptotic, growth-stimulatory receptor-ligand pair that play an important role in human tumorigenesis...
  43. Genetic Epidemiology of Breast Cancer: BRCA1 and BRCA2
    Susan Neuhausen; Fiscal Year: 2007
    ..This information can be used to assist women and their physicians in individual risk assessment, as well as to target women for specific prevention or treatment strategies based on their genetic risk factors. ..
  44. GENETIC MODULATION OF CELLULAR RADIATION RESPONSES
    Kristoffer Valerie; Fiscal Year: 2007
    ..abstract_text> ..
  45. Treatment of Breast Cancer with IGFBP1
    Douglas Yee; Fiscal Year: 2006
    ..Our long-term goal is to prove that the IGFs are key targets for the treatment of breast cancer. By optimizing IGF neutralization strategies, we will be prepared to move this anti-IGF strategy into the clinic. ..
  46. Mechanism of IGF-I actions on oligodendroglial cells
    AUGUSTINE D ERCOLE; Fiscal Year: 2008
    ..and spatially related to the injury; 4) IGF-I protects myelination from a variety of CNS injury; and 5) blunting IGFIR expression specifically in oligodendrocytes results in brain retardation and hypomyelination in the mutant mice...
  47. THE HORMONAL CONTROL OF FETAL GROWTH
    AUGUSTINE D ERCOLE; Fiscal Year: 2009
    ..Determine the consequences of neonatal ischemia/hypoxia on DG neurogenesis in normal and IGF-I and IGF1R mutant mice. ..
  48. IGF-I Actions in Oligodendrocyte/Myelin Injury
    AUGUSTINE D ERCOLE; Fiscal Year: 2007
    ..abstract_text> ..
  49. Antisense Morpholino Oligomers to Treat Retinopathy
    Gayathri Devi; Fiscal Year: 2003
    ..The primary goal of this grant is to identify the optimal antisense alphav PMO, dose and schedule that maximally decreases alpha V expression and inhibits retinopathy of prematurity. ..
  50. Inhibition of Androgen Receptor to treat Prostate Cancer
    Gayathri Devi; Fiscal Year: 2003
    ..Based on these data, future pharmacokinetic and toxicology animal studies will allow proceeding to human phase I testing in a timely and efficient manner. ..
  51. Leptin modulation of insulin action in the islet b-cell
    Rohit Kulkarni; Fiscal Year: 2005
    ..abstract_text> ..
  52. 2003 Gordon Conference on Proteins
    Lynne Regan; Fiscal Year: 2003
    ..Finally, the organizers are particularly sensitive to ensuring the full representation of women and minorities in this meeting. ..
  53. INHIBITION OF BREAST TUMORIGENICITY BY C MYC PO RNA
    SCOTT BLUME; Fiscal Year: 2002
    ..3. Assess the degree to which artificial manipulation of the PO 5'-untranslated sequence alters the inherent tumorigenic, invasive, and metastatic potential of human breast carcinoma xenografts in immunocompromised mice. ..
  54. Molecular Dissection of IGF2R Growth Suppressor Activity
    Richard MacDonald; Fiscal Year: 2004
    ..These studies will contribute to understanding the receptor's tumor suppressor function and permit rational design of strategies that exploit the IGF2R in cancer prevention and therapy. ..
  55. INVESTIGATING THE MECHANISMS OF PRB TUMOR SUPPRESSION
    Arnab Chakravarti; Fiscal Year: 2003
    ..Specific Aim number 3: To determine whether the deregulation of E2F dependent transcription is correlated with the tumorigenic potential of RB -/- cells in-vivo. ..
  56. STRUCTURE FUNCTION & FOLDING OF AN RNA BINDING PROTEIN
    Lynne Regan; Fiscal Year: 2003
    ....
  57. SIGNAL TRANSDUCTION BY TYROSINE KINASES
    Michael Weber; Fiscal Year: 2001
    ..These investigations will assess a) the role of PI 3-kinase b) the regulation of stress kinases, c) the participation of the bcl-2 family in IGF-I receptor signaling, and d) the role of a newly identified MEK activator. ..
  58. Diabetes Genome Anatomy Project (DGAP)
    C Kahn; Fiscal Year: 2006
    ..abstract_text> ..
  59. Expression of Proapoptotic Genes for Cancer Therapy
    Bingliang Fang; Fiscal Year: 2006
    ..Success of the proposed studies will lead to new therapeutics for refractory metastatic disease. It will also provide insight into mechanisms of resistance to apoptosis induction in cancer cells. ..
  60. INSULIN & GLUCOSE SIGNALING PATHWAYS IN ISLET BETA CELLS
    Rohit Kulkarni; Fiscal Year: 2004
    ....
  61. Silibinin in Prostate Cancer Chemoprevention & Treatment
    Michael Pollak; Fiscal Year: 2004
    ..The work is justified by the favorable toxicity profile of silibinin, together with prior positive laboratory studies reported by our group and other investigators. ..
  62. TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGE
    Arlan Richardson; Fiscal Year: 2001
    ..4. To measure parameters of mitochondrial function (e.g., mitochondrial respiration, hydrogen peroxide generation, and permeability transition) in tissues of wild type, Sod2+/-, and Sod2+/-XGpx1+/-F1 mice at 5, 14 and 26 moths of age. ..
  63. Regulation of autocrine IGF-I signaling by Connexin 43
    GINA YANOCHKO; Fiscal Year: 2005
    ..The goal of Specific Aim 2 is to examine the effect of IGFIR activation on gap junctional communication...
  64. BETA SHEET FORMATION IN A SIMPLE MODEL SYSTEM
    Lynne Regan; Fiscal Year: 2006
    ..The split GFP system also provides a means by which to identify binding partners for "orphan proteins" whose interaction partners are not yet known. ..
  65. Genomic Landscapes in Large Scale Integrated JRA Studies
    Susan Thompson; Fiscal Year: 2006
    ..Furthermore, we address the hypothesis that a joint analysis of IL-4 and IL-6 expression levels and polymorphisms can be used for more accurate discrimination of polyarticular and systemic JRA versus pauciarticular JRA. ..
  66. Dissecting the Death Pathway in Islet Beta Cells
    Rohit Kulkarni; Fiscal Year: 2005
    ..abstract_text> ..
  67. BENIGN BREAST DISEASE AND RISK OF BREAST CANCER
    Rulla Tamimi; Fiscal Year: 2009
    ..The creation of tissue microarrays using benign breast tissue will lay the foundation for this and future studies to efficiently examine the role of molecular markers in the development of breast cancer. ..
  68. Role of ghrelin in intestinal inflammation
    Dezheng Zhao; Fiscal Year: 2008
    ....
  69. DETERMINANTS OF TISSUE ESTRADIOL SENSITIVITY
    Richard Santen; Fiscal Year: 2009
    ..FTS, a novel mTOR inhibitor will be used in vitro to activate the stress kinase pathway and apoptosis. In vivo, FTS will be used to enhance estradiol induced apoptosis in nude mice. ..
  70. FluorImager/Storm System
    Robert Weinberg; Fiscal Year: 2002
    ..The 8 laboratory groups which are prospective users of this instrument spend an aggregate $72,000 yearly on autoradiographic supplies and equipment, much of which expense would be obviated by the proposed instrument. ..
  71. CONFERENCE ON DIABETES MELLITUS
    C Kahn; Fiscal Year: 2002
    ..Keystone conferences on diabetes have been held every 2-3 years, and have had increasing registration approaching 600 people (when combined with the obesity conference). ..
  72. Role of Leptin in Islet Growth
    Rohit Kulkarni; Fiscal Year: 2008
    ..The proposed studies are aimed at the long-term goal of developing therapeutic strategies to prevent or delay the development of diabetes in obese individuals. [unreadable] [unreadable] [unreadable]..
  73. A Novel Computational Framework for Individualized Clinical Decision-Making
    Nancy Lan Guo; Fiscal Year: 2010
    ..This study will advance the computational modeling of human genome data in disease for clinical decision-making. ..
  74. GENE EXPRESSION IN DIABETES BY SUBTRACTIVE CLONING
    C Kahn; Fiscal Year: 2003
    ..In addition, 6 type 2 DM having low S1 and SG on fs-IVGTT will be compared with 6 offspring with high S1 and high SG, and 6 normoglycemic obese will be compared with 6 lean subjects, for differential expression in muscle and fat. ..
  75. Androgen and Growth Factor Signaling in Prostate Cancer
    Michael Weber; Fiscal Year: 2008
    ..This research will be informative with respect to understanding the integration of steroid and growth factor signaling, as well as in identifying the optimal therapeutic targets for advanced prostate cancer. ..
  76. Vitamin D and Mammographic Density
    Rulla Tamimi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  77. TGF-beta Signaling in Mesenchymal Chondroprogenitors
    Anna Spagnoli; Fiscal Year: 2007
    ..Understanding the role of TGF-beta in MCC biology will provide a framework for therapeutic manipulations to optimize the use of MCC in cartilage diseases. ..
  78. SAGE Analysis of Murine Oocyte Maturation
    CHARLOTTE FARIN; Fiscal Year: 2004
    ..Differential expression of the candidate gene sequences will be verified using reverse transcription-polymerase chain reaction (RT-PCR). ..
  79. NUTRITIONAL PROBE OF THE AGING PROCESS
    Arlan Richardson; Fiscal Year: 2003
    ..The Developmental Core will generate and characterize transgenic models that allow temporal control of transgene expression to further test the aforementioned and other potential mechanisms in the next generation of DR research. ..
  80. HTP assays of inhibitors of protein-protein interactions
    Lynne Regan; Fiscal Year: 2007
    ..We will follow-up potential leads by assaying their ability to reverse the oncogenic phenotype in HTP morphology assays. Promising compounds will go forward into trials in collaboration with other researchers. ..