IGF-1

Summary

Gene Symbol: IGF-1
Description: insulin like growth factor 1
Alias: IGF-I, IGFI, MGF, insulin-like growth factor I, insulin-like growth factor 1 (somatomedin C), insulin-like growth factor IB, mechano growth factor, somatomedin-C
Species: human

Top Publications

  1. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
  2. doi Insulin-like growth factor I serum levels influence ischemic stroke outcome
    Ann De Smedt
    Department of Neurology, Center for Neurosciences, Universitair Ziekenhuis Brussel, Brussels, Belgium
    Stroke 42:2180-5. 2011
  3. ncbi 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort
    Elina Hypponen
    Center for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford St, London, WC1N 1EH, UK
    Diabetes 57:298-305. 2008
  4. doi Serum IGF-I levels correlate to improvement of functional outcome after ischemic stroke
    Daniel Aberg
    Laboratory of Experimental Endocrinology, Sahlgrenska University Hospital, The SahlgrenskaAcademy at University of Gothenburg, SE 413 45 Goteborg, Sweden
    J Clin Endocrinol Metab 96:E1055-64. 2011
  5. pmc Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer
    H Jernstrom
    Department of Oncology, The Jubileum Institute, Lund University Hospital, Lund SE 221 85, Sweden
    Br J Cancer 92:857-66. 2005
  6. ncbi Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor
    Meletios Verras
    Department of Urology, R135, Edwards Building, Stanford University School of Medicine, Stanford, California 94305 5328, USA
    Mol Endocrinol 19:391-8. 2005
  7. ncbi Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells
    Eun Joung Lim
    Department of Pathology, School of Medicine, and Institute of Biomedical Science and Technology, Konkuk University, Seoul 143 701, Korea
    Int J Oncol 36:1243-51. 2010
  8. pmc Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab
    A Gualberto
    The Department of Clinical Development and Medical Affairs, Pfizer Oncology, New London, CT 06320, USA
    Br J Cancer 104:68-74. 2011
  9. ncbi Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Blood 110:4243-52. 2007
  10. ncbi The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin
    E Rinderknecht
    J Biol Chem 253:2769-76. 1978

Research Grants

  1. CHRISTOPHER JOSEPH ROMERO; Fiscal Year: 2014
  2. Jill M Daniel; Fiscal Year: 2016
  3. Aging and IGF-1 Receptor in a three dimensional matrix
    Itay Bentov; Fiscal Year: 2013
  4. Jeffrey B Travers; Fiscal Year: 2016
  5. PETER S ROTWEIN; Fiscal Year: 2014
  6. Thomas L Clemens; Fiscal Year: 2014
  7. Physiologic Role of the Somatotroph IGF-1 Receptor
    Christopher Romero; Fiscal Year: 2009
  8. C Ronald Kahn; Fiscal Year: 2016
  9. Akt/mTOR Signaling in Energy Balance Modulation of Epithelial Carcinogenesis
    Stephen D Hursting; Fiscal Year: 2013
  10. Vivek Bhalla; Fiscal Year: 2015

Detail Information

Publications378 found, 100 shown here

  1. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  2. doi Insulin-like growth factor I serum levels influence ischemic stroke outcome
    Ann De Smedt
    Department of Neurology, Center for Neurosciences, Universitair Ziekenhuis Brussel, Brussels, Belgium
    Stroke 42:2180-5. 2011
    ..Insulin-like growth factor I (IGF-I) is neuroprotective in animal models of stroke. We investigated whether serum IGF-I levels in patients with acute ischemic stroke influence stroke severity and outcome...
  3. ncbi 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort
    Elina Hypponen
    Center for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford St, London, WC1N 1EH, UK
    Diabetes 57:298-305. 2008
    ..Physiological interactions between vitamin D and IGF-1 are reported; this is the first study to investigate their combined associations with metabolic syndrome prevalence...
  4. doi Serum IGF-I levels correlate to improvement of functional outcome after ischemic stroke
    Daniel Aberg
    Laboratory of Experimental Endocrinology, Sahlgrenska University Hospital, The SahlgrenskaAcademy at University of Gothenburg, SE 413 45 Goteborg, Sweden
    J Clin Endocrinol Metab 96:E1055-64. 2011
    ..We investigated whether the endogenous serum IGF-I (s-IGF-I) levels correlated with recovery of functional independence in patients who had suffered an ischemic stroke...
  5. pmc Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer
    H Jernstrom
    Department of Oncology, The Jubileum Institute, Lund University Hospital, Lund SE 221 85, Sweden
    Br J Cancer 92:857-66. 2005
    ..002). Our results suggest that lack of the IGF1 19-repeat allele modifies IGF-1 levels, breast volume and possibly early-onset breast cancer risk after hormone exposure in young high-risk women...
  6. ncbi Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor
    Meletios Verras
    Department of Urology, R135, Edwards Building, Stanford University School of Medicine, Stanford, California 94305 5328, USA
    Mol Endocrinol 19:391-8. 2005
    ..Moreover, using a pulse-chase experiment, we showed that IGF-I enhances the stability of beta-catenin in prostate cancer cells. Our findings delineate a novel pathway for IGF-I in modulating androgen signaling through beta-catenin...
  7. ncbi Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells
    Eun Joung Lim
    Department of Pathology, School of Medicine, and Institute of Biomedical Science and Technology, Konkuk University, Seoul 143 701, Korea
    Int J Oncol 36:1243-51. 2010
    ..These findings are valuable toward understanding the role of hemin-induced inhibition of cyclin D1 and IGF-1 expression under hypoxia in invasive and metastatic breast cancer...
  8. pmc Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab
    A Gualberto
    The Department of Clinical Development and Medical Affairs, Pfizer Oncology, New London, CT 06320, USA
    Br J Cancer 104:68-74. 2011
    ..Here, we investigated a role of free IGF-1 (fIGF-1) as a potential predictive biomarker of clinical benefit from F treatment...
  9. ncbi Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway
    Ingeborg Hers
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Blood 110:4243-52. 2007
    ..These results demonstrate that IGF-1 activates the IGF receptor/IRS/PI3K/PKB pathway, and that PI3Kalpha is essential for the potentiatory effect of IGF-1 on platelet responses...
  10. ncbi The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin
    E Rinderknecht
    J Biol Chem 253:2769-76. 1978
    ..The fact that all half-cystine and glycine residues and most nonpolar core residues of the insulin monomer are conserved is compatible with a three-dimensional structure of IGF-I similar to that of insulin...
  11. ncbi Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels
    Patrice Delafontaine
    Section of Cardiology, School of Medicine, Tulane University Medical Center, 1430 Tulane Ave, New Orleans, LA 70112 2699, USA
    Arterioscler Thromb Vasc Biol 24:435-44. 2004
    ..This review will discuss the regulation of expression of IGF-1, IGF-1R, and IGF binding proteins in the vasculature and summarize evidence implicating involvement of this system in vascular diseases...
  12. ncbi The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study
    Gail A Laughlin
    Department of Family and Preventive Medicine, University of California San Diego School of Medicine, La Jolla, California 92093 0607
    J Clin Endocrinol Metab 89:114-20. 2004
    ..We conclude that low baseline levels of IGF-I and IGFBP-1 increase the risk of fatal IHD among elderly men and women independent of prevalent IHD and CVD risk factors...
  13. pmc Human insulin/IGF-1 and familial longevity at middle age
    Maarten P Rozing
    Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    Aging (Albany NY) 1:714-22. 2009
    ....
  14. pmc A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3
    Robert C Kaplan
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hum Mol Genet 20:1241-51. 2011
    ..These genetic loci deserve further investigation to elucidate the biological basis for the observed associations and clarify their possible role in IGF-mediated regulation of cell growth and metabolism...
  15. pmc Mesenchymally-derived insulin-like growth factor 1 provides a paracrine stimulus for trophoblast migration
    Helen Lacey
    Schools of Medicine and Biological Sciences University of Manchester, Manchester, UK
    BMC Dev Biol 2:5. 2002
    ..At the periphery of the placenta, chorionic villi make contact with decidua to form specialised anchoring sites that feed interstitially migrating cytotrophoblast into the placental bed...
  16. ncbi The paradox of the insulin/IGF-1 signaling pathway in longevity
    Marielisa Rincon
    Department of Medicine, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Belfer Bld 701, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mech Ageing Dev 125:397-403. 2004
    ..In this review we focus on the downstream cascade of events in the insulin and IGF-1 signaling to identify specific pathways that are relevant to human longevity...
  17. ncbi AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1
    Caroline Treins
    Institut National de la Santé et de la Recherche Médicale U145, Nice, France
    Biochem Biophys Res Commun 342:1197-202. 2006
    ..Moreover, AICAR and metformin inhibited the ability of insulin and IGF-1 to induce HIF-1alpha expression. These results show that AICAR and insulin/IGF-1 regulate VEGF expression through different mechanisms...
  18. ncbi In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth
    Laura Conti
    Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, Turin, Italy
    Blood 109:2496-504. 2007
    ..These data indicate that the inhibition of IGF-1 signaling combined with IFN-gamma administration could be a promising approach to suppress the growth of neoplastic T cells resistant to each treatment on its own...
  19. pmc Insulin-like growth factor-1 promoter polymorphisms and colorectal cancer: a functional genomics approach
    H L Wong
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DDHS, Rockville, Maryland, USA
    Gut 57:1090-6. 2008
    ..While genetic factors explain at least half of inter-individual IGF1 variation, the IGF1 polymorphisms hypothesised to underlie the variation in cancer incidence rates remain ill-defined...
  20. doi IGF-1-overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1alpha/CXCR4 signaling to promote myocardial repair
    Husnain Kh Haider
    Department of Pathology and Laboratory of Medicine, 231 Albert Sabin Way, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Circ Res 103:1300-8. 2008
    ..05). In conclusion, the strategy of IGF-1 transgene expression induced massive stem cell mobilization via SDF-1alpha signaling and culminated in extensive angiomyogenesis in the infarcted heart...
  21. ncbi Insulin like growth factor-1 and insulin like growth factor binding proteins in the cerebrospinal fluid and serum from patients with Alzheimer's disease
    Zivar Salehi
    Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
    Biofactors 33:99-106. 2008
    ..The data from this study indicate that IGF-1 is a constant component of human CSF. It is also concluded that high levels of CSF IGF-1 may be partly related to AD pathophysiology...
  22. doi Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 18:833-41. 2009
    ..Persistent acne in adulthood with high IGF-1 levels may be considered as an indicator for increased risk of cancer, which may require appropriate dietary intervention as well as treatment with insulin-sensitizing agents...
  23. pmc Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription
    Jeremie Boucher
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 285:17235-45. 2010
    ..Thus, IR and IGF1R act as identical portals to the regulation of gene expression, with differences between insulin and IGF-1 effects due to a modulation of the amplitude of the signal created by the specific ligand-receptor interaction...
  24. doi Short stature associated with a novel heterozygous mutation in the insulin-like growth factor 1 gene
    H A van Duyvenvoorde
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 95:E363-7. 2010
    ..Homozygous IGF1 deletions or mutations lead to severe short stature, deafness, microcephaly, and mental retardation. Heterozygosity for an IGF-I defect may modestly decrease height and head circumference...
  25. doi IGF-1 splice variant and IGF-1 peptide expression patterns in young and old human skeletal muscle prior to and following sequential exercise bouts
    Michael D Roberts
    Health and Exercise Science Department, University of Oklahoma, Norman, OK 73019 6081, USA
    Eur J Appl Physiol 110:961-9. 2010
    ..of conventional resistance training meant to elicit hypertrophy affect the mRNA expression of IGF-1EA and IGF-1EC (MGF) as well as the expression of total IGF-1 peptides in human skeletal muscle...
  26. doi A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1 -2 and -3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Francesca L Crowe
    Nuffield Department of Clinical Medicine, University of Oxford, UK
    Ann Hum Biol 38:194-202. 2011
    ..Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk...
  27. doi Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages
    Prashanth Kumar Kandalla
    Thérapie des maladies du muscle strié, Institut de Myologie, Universite Pierre et Marie Curie, G H Pitié Salpêtrière, 47 bd de l Hopital, Paris, France
    Mech Ageing Dev 132:154-62. 2011
    Loss of muscle mass and strength is a major problem during aging and the expression of Mechano Growth Factor (MGF), a member of the IGF-1 (insulin-like Growth Factor 1) super family, has been shown to be both exercise and age dependent...
  28. doi Associations of IGF1 and IGFBPs 1 and 3 with all-cause and cardiovascular mortality in older men: the Health In Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Eur J Endocrinol 164:715-23. 2011
    ..We examined associations of IGF1, IGFBP1 and IGFBP3 with all-cause and cardiovascular mortality in older men...
  29. doi Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart
    Georgina M Ellison
    The Stem Cell and Regenerative Biology Unit BioStem, RISES, Liverpool John Moores University, Liverpool, UK
    J Am Coll Cardiol 58:977-86. 2011
    ....
  30. ncbi The multifunctional role of IGF-1 in peripheral nerve regeneration
    Eric D Rabinovsky
    Michael E DeBakey Department of Surgery, Division of Plastic Surgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Neurol Res 26:204-10. 2004
    ..This review will outline the pathways by which IGF-1 affects multiple layers of the regenerative response and how these pathways converge to promote the regeneration of nerves...
  31. ncbi IGF-1 induces human myotube hypertrophy by increasing cell recruitment
    V Jacquemin
    CNRS UMR 7000 Cytosquelette et Développement, Paris, France
    Exp Cell Res 299:148-58. 2004
    ..In addition, muscle hypertrophy can be triggered in the absence of proliferation by recruiting more mononucleated cells. We propose that IGF-1-induced hypertrophy can involve the recruitment of reserve cells in human skeletal muscle...
  32. pmc MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II
    Hariyadarshi Pannu
    Department of Internal Medicine and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Hum Mol Genet 16:2453-62. 2007
    ..These data suggest that MYH11 mutations are likely to be specific to the phenotype of TAAD/PDA and result in a distinct aortic and occlusive vascular pathology potentially driven by IGF-1 and Ang II...
  33. pmc IGF-1 and IGF-binding proteins and bone mass, geometry, and strength: relation to metabolic control in adolescent girls with type 1 diabetes
    Laurie J Moyer-Mileur
    Center for Pediatric Nutrition Research, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA
    J Bone Miner Res 23:1884-91. 2008
    ....
  34. pmc The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor
    Anne Catherine Sprynski
    INSERM U847, Montpellier, France
    Blood 113:4614-26. 2009
    ..Thus, IGF-1-targeted therapy, eventually in combination with anti-IL-6 therapy, could be promising in a subset of patients with MMCs expressing IGF-1R...
  35. pmc Peroxisome proliferator-activated receptor (PPAR) gene profiling uncovers insulin-like growth factor-1 as a PPARalpha target gene in cardioprotection
    Hamid el Azzouzi
    Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, 3584 CS Utrecht, The Netherlands
    J Biol Chem 286:14598-607. 2011
    ..Taken together, these data confirm igf-1 as an in vivo target of PPARα and the involvement of a PPARα/IGF-1 signaling pathway in the protection of cardiomyocytes under ischemic and hemodynamic loading conditions...
  36. pmc Higher levels of IGF-I and adrenal androgens at age 8 years are associated with earlier age at menarche in girls
    Ajay Thankamony
    Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 97:E786-90. 2012
    ..Earlier age at menarche is associated with rapid infancy weight gain and childhood obesity. The role of hormone levels in mediating these associations is unclear...
  37. doi Pluripotency of mouse spermatogonial stem cells maintained by IGF-1- dependent pathway
    Yen Hua Huang
    Department of Biochemistry, Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, Taipei, Taiwan
    FASEB J 23:2076-87. 2009
    ....
  38. pmc The IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer
    D A Lewis
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Oncogene 29:1475-85. 2010
    ....
  39. doi IGF-1:tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice
    Ru Ju Chian
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA
    Brain Res 1287:1-19. 2009
    ..IGF-1:TTC may prove to be neuroprotective in other animal models of CNS disease or injury known to be responsive to unmodified IGF-1...
  40. pmc Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival
    Jin E Yao
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou, PR China
    Mol Cancer 8:95. 2009
    ..As a bona fide oncoprotein, Aurora-A aberrant overexpression leads to oncogenic transformation. Yet, the mechanisms by which Aurora-A enhances cancer cell survival remain to be elucidated...
  41. ncbi IGF-1 activates p21 to inhibit UV-induced cell death
    Stephen A Murray
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 20118, USA
    Oncogene 22:1703-11. 2003
    ..Furthermore, p21 is important for IGF-1-mediated cell survival upon UV irradiation. Taken together, these data indicate that IGF-1 may activate p21 in executing its survival function upon genotoxic insults...
  42. doi Effects of insulin-like growth factor 1 in preventing acute coronary syndromes: the PRIME study
    J B Ruidavets
    Department of Epidemiology, Toulouse University School of Medicine, Toulouse, France
    Atherosclerosis 218:464-9. 2011
    ..The aim of the present study was to evaluate the prognostic value of IGF-1 concentrations with respect to occurrence of well-defined coronary syndromes...
  43. pmc Decline in circulating insulin-like growth factors and mortality in older adults: cardiovascular health study all-stars study
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Endocrinol Metab 97:1970-6. 2012
    ..The association between changes in IGF-I and IGF binding protein (IGFBP) levels and mortality in older adults is unknown...
  44. pmc Insulin-like growth factor axis and risk of type 2 diabetes in women
    Swapnil N Rajpathak
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 61:2248-54. 2012
    ..05-6.06]; P trend < 0.05). Thus, this prospective study found strong associations of incident diabetes with baseline levels of three IGFBPs and free IGF-I, consistent with hypotheses that the IGF axis might influence diabetes risk...
  45. doi The PI3K/Akt/mTOR signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells
    Man Tat Lau
    Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    Cancer Lett 326:191-8. 2012
    ..This study demonstrates a novel mechanism in which IGF1 down-regulates E-cadherin expression through the activation of PI3K/Akt/mTOR signaling and the up-regulation of Snail and Slug in human ovarian cancer cells...
  46. pmc Possible roles of insulin, IGF-1 and IGFBPs in initiation and progression of colorectal cancer
    Bo Jiang
    Bo Jiang, Xin Zhang, Dong Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China
    World J Gastroenterol 20:1608-13. 2014
    ..To investigate the roles of serum insulin, insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding proteins (IGFBPs) in the initiation and progression of colorectal cancer...
  47. ncbi A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction
    N Vaessen
    Department of Epidemiology and Biostatistics, the Center for Biomedical Genetics, Rotterdam, The Netherlands
    Diabetes 50:637-42. 2001
    ..4 (95% CI 1.1-11.3). Our study suggests that a genetically determined exposure to relatively low IGF-I levels is associated with an increased risk for type 2 diabetes and myocardial infarction...
  48. ncbi Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States
    M L Slattery
    University of Utah, Salt Lake City, Utah 84108, USA
    Breast Cancer Res Treat 104:197-209. 2007
    ..An insulin-related pathway to breast cancer has been hypothesized...
  49. ncbi Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females
    Jian Zhao
    The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi an Jiaotong University, Xi an 710049, People s Republic of China
    Hum Reprod 22:1789-94. 2007
    ..Our study aimed to test association between IGF1 polymorphisms with the variation of age at menarche (AAM) in Caucasian females...
  50. doi Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk
    Elisabeth Feik
    Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria
    Cancer Causes Control 21:91-7. 2010
    ..The purpose of this study was to examine the association of genetic variants in IGF1 (rs6214, rs6220, and rs35767) and IGFBP3 (rs2854744 and rs2854746) with risk of colorectal polyps and colorectal cancer...
  51. pmc ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability
    E M Goetz
    Departments of Oncology, Pharmacology, and Radiation Oncology, Laboratory of Molecular Stress Responses, University of Texas Southwestern Medical Center at Dallas, TX, USA
    Oncogene 30:3745-54. 2011
    ..Elucidation of this pathway should uncover new mechanisms for cancer progression and reveal new targets for drug development to overcome resistance to therapy...
  52. doi Insulin-like growth factor I correlates with MELD and returns to normal level after liver transplantation
    Gustavo R A Castro
    Division of Liver Transplantation of the Federal University of Parana, Curitiba, Brazil
    Ann Transplant 18:57-62. 2013
    ..We also assessed the changes of IGF-I and its major binding protein (IGF-binding protein-3 or IGFBP-3) after OLT...
  53. ncbi Insulin-like growth factor I polymorphism and breast cancer risk in Jewish women
    Arie Figer
    Oncology Institute, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel
    Isr Med Assoc J 4:759-62. 2002
    ..An attractive candidate is the insulin-like growth factor I, a known mitogen to mammary ductal cells in vivo and in vitro, whose serum levels were reportedly elevated in breast cancer patients...
  54. ncbi Genetic factors and insulin secretion: gene variants in the IGF genes
    Leen M 't Hart
    Deparment of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 53:S26-30. 2004
    ..Further studies are needed to examine the exact contributions of the IGF-I CA repeat alleles to variations in ISI and DI...
  55. ncbi An insulin-like growth factor-I gene polymorphism modifies the risk of microalbuminuria in subjects with an abnormal glucose tolerance
    I Rietveld
    Department of Internal Medicine, Rotterdam, The Netherlands
    Eur J Endocrinol 154:715-21. 2006
    ..Microalbuminuria (MA) is related to cardiovascular disease both in diabetic patients and non-diabetic subjects...
  56. pmc IGF-1 gene polymorphisms in Polish families with high-grade myopia
    Malgorzata Rydzanicz
    Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland
    Mol Vis 17:2428-39. 2011
    ..We investigated whether the IGF-1 single nucleotide polymorphisms (SNPs) rs6214, rs10860860, and rs2946834 are associated with HM (≤-6.0 diopters [D]) and any myopia (≤-0.5 D) phenotype in Polish families...
  57. ncbi Elevated insulin-like growth factor-1 and insulin-like growth factor binding protein-2 in malignant pleural effusion
    David Olchovsky
    Department of Medicine A, Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Acta Oncol 41:182-7. 2002
    ..This work demonstrates the existence of the IGF-1/IGFBP system in pleural fluids from different etiologies and implies possible use of IGF-1 and IGFBP-2 as a potential marker of malignant effusions...
  58. ncbi Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients
    Giorgio Sesti
    Unit of Internal Medicine, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Italy
    J Hypertens 25:471-7. 2007
    ..We investigated the role of the GH/IGF-1 axis on LVM and ventricular geometry in a group of 230 never-treated hypertensive patients...
  59. doi Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes
    Yong Yang
    Chinese Academy of Medical Sciences, Department of Orthopedics, Peking Union Medical College, Beijing, China
    Orthopedics 32:411. 2009
    ..A conclusion was made confirming the insufficiency of an association between adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes in Han Chinese...
  60. doi Serum IGF-1 concentrations in a sample of patients with traumatic brain injury as a diagnostic marker of growth hormone secretory response to glucagon stimulation testing
    Dennis J Zgaljardic
    Department of Neuropsychology, Transitional Learning Center, Galveston, TX 77550, USA
    Clin Endocrinol (Oxf) 74:365-9. 2011
    ..We report in this study our experience using the glucagon stimulation test (GST) in assessing GHD in adult patients with traumatic brain injury (TBI) as it relates to baseline serum insulin-like growth factor-1 (IGF-1) concentrations...
  61. ncbi Total alanine-scanning mutagenesis of insulin-like growth factor I (IGF-I) identifies differential binding epitopes for IGFBP-1 and IGFBP-3
    Y Dubaquie
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    Biochemistry 38:6386-96. 1999
    ..The fact that the functional binding epitopes on IGF-I are overlapping but distinct for both binding proteins may be exploited to design binding protein-specific IGF variants...
  62. ncbi Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study
    R M Cooke
    Department of Biochemistry, University of Oxford, U K
    Biochemistry 30:5484-91. 1991
    ..The resultant structures have been used to visualize the sites for interaction with a number of physiologically important proteins...
  63. ncbi IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry
    Han You
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Cell Biochem 84:211-6. 2002
    ..Thus, these data suggest that the mitogenic function of IGF-1 is at least partially linked to the induction of Pin1, which in turn stimulates cyclin D1 expression and RB phosphorylation, therefore contributing to G0/G1-S transition...
  64. ncbi Control of ceramide-induced apoptosis by IGF-1: involvement of PI-3 kinase, caspase-3 and catalase
    T Kondo
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Syogoin Kawaramachi, Sakyo ku, Kyoto 606 8507, Japan
    Cell Death Differ 9:682-92. 2002
    ..In summary, these results suggest that IGF-1/PI-3 kinase inhibited C2-ceramide-induced apoptosis due to relieving oxidative damage, which resulted from the inhibition of catalase by activated caspase-3...
  65. ncbi Insulin-like growth factor type 1 prevents hyperglycemia-induced uncoupling protein 3 down-regulation and oxidative stress
    Helena Gustafsson
    Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, Sweden
    J Neurosci Res 77:285-91. 2004
    ..These data indicate that IGF-1 may protect from hyperglycemia-induced oxidative stress and neuronal injuries by regulating MMP, possibly by the involvement of UCP3...
  66. ncbi Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2
    Adele Hartnell
    Leukocyte Biology Section, Biomedical Science Division, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
    J Immunol 173:6448-57. 2004
    ..This is the first demonstration of chemokinetic factors that increase the motility of basophils, but do not act on other granulocytes or monocytes. IGF-1 and IGF-2 could play a role in the selective recruitment of basophils in vivo...
  67. pmc Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells
    Amandine Hurbin
    Groupe de Recherche sur le Cancer du Poumon, INSERM U578, Institut Albert Bonniot, La Tronche, France
    J Biol Chem 280:19757-67. 2005
    ..Thus, AR and IGF1 cooperate to prevent apoptosis by activating a specific PKC-p90(rsk)-dependent pathway, which leads to Bad and Bax inactivation. This signaling pathway is different to that used by single factor...
  68. ncbi Inverse correlation between serum free IGF-I and IGFBP-3 levels and blood pressure in patients affected with type 1 diabetes
    Ettore Capoluongo
    Laboratory of Molecular Biology, Institute of Biochemistry and Clinical Biochemistry, Catholic University, Rome, Italy
    Cytokine 34:303-11. 2006
    ..In addition, no information is available on type 1 diabetes patients...
  69. ncbi Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes
    Zorica Zakula
    Institute Vinca, Laboratory for Molecular Genetics and Radiobiology, 11000 Belgrade, Serbia and Montenegro
    Med Hypotheses 69:302-6. 2007
    ..Future investigations should now focus on mechanisms of action of IGF-1 and its clinical applicability...
  70. ncbi Insulin and insulin-like growth factor type-I up-regulate the vanilloid receptor-1 (TRPV1) in stably TRPV1-expressing SH-SY5Y neuroblastoma cells
    Johanna Lilja
    Department of Neurochemistry, Stockholm University, Stockholm, Sweden
    J Neurosci Res 85:1413-9. 2007
    ..We conclude that IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system...
  71. ncbi Phosphatidylinositol 3-kinase/nuclear factor-kappa B signaling pathway is involved in the regulation of IGF-I on Fas-associated death domain-like interleukin-1-converting enzyme-inhibitory protein expression in cultured FRTL thyroid cells
    Meng Ren
    Central Laboratory, Shandong University, Jinan, China
    J Mol Endocrinol 38:619-25. 2007
    ..Taken together, our results suggest that IGF-I regulates the expression of FLIP in FRTL cells by activating the PI3K/NF-kappaB cascade...
  72. ncbi Association of IGF-1 and IGFBP-3 with lower urinary tract symptoms in the third national health and nutrition examination survey
    Sabine Rohrmann
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Prostate 67:1693-8. 2007
    ..It is, however, unclear which factors induce prostate growth in these men. We examined the association of insulin-like growth factor (IGF)-1 and its major binding protein IGFBP-3 with LUTS in a representative US study...
  73. ncbi Impact of serum insulin-like growth factor-1 on early prognosis in acute myocardial infarction
    Hiroshi Yamaguchi
    Division of Cardiology, Health Insurance Naruto Hospital, Naruto
    Intern Med 47:819-25. 2008
    ..We hypothesized that the serum IGF-1 level affects clinical outcome in acute myocardial infarction (AMI). We examined the impact of serum IGF-1 in acute phase of AMI on 90-day mortality...
  74. doi Filamin A is a novel caveolin-1-dependent target in IGF-I-stimulated cancer cell migration
    Dana Ravid
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Exp Cell Res 314:2762-73. 2008
    ..These data indicate that caveolin-1 specifies filamin A as a novel target for Akt-mediated filamin A Ser-2152 phosphorylation thus mediating the effects of caveolin-1 on IGF-I-induced cancer cell migration...
  75. pmc Plasma insulinlike growth factor 1 and binding-protein 3 and risk of myocardial infarction in women: a prospective study
    John H Page
    Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Clin Chem 54:1682-8. 2008
    ....
  76. doi YY1 Over-expression in human brain gliomas and meningiomas correlates with TGF-beta1, IGF-1 and FGF-2 mRNA levels
    Stavroula Baritaki
    Department of Clinical Virology, Medical School, University of Crete, Crete, Greece
    Cancer Invest 27:184-92. 2009
    ..We suggest that mRNA profiling of the above genes in the early stages of disease development could be useful for prognostic purposes, and these genes can be considered as potential targets for therapeutic approaches against brain tumors...
  77. doi Inhibition of glycogen synthase kinase-3 enhances the expression of alkaline phosphatase and insulin-like growth factor-1 in human primary dermal papilla cell culture and maintains mouse hair bulbs in organ culture
    Koichi Yamauchi
    Hair Clinic Reve 21 Corporation, 2 1 61 Shiromi, Chuo Ku, Osaka 540 6122, Japan
    Arch Dermatol Res 301:357-65. 2009
    ..Thus, treatment with BIO may be useful to prepare DP cells with hair follicle-inducing activity...
  78. doi IGF-I regulated phosphorylation and translocation of PDK-1 in neurons
    Betty B Alajajian
    Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Neuroreport 20:579-83. 2009
    ..Our findings suggest that IGF-I may regulate neuronal PDK-1 differently than in non-neuronal cells, which may indicate a novel role for PDK-1 in IGF-I-mediated neuroprotective signaling...
  79. pmc Treating human meniscal fibrochondrocytes with hIGF-1 gene by liposome
    Hai ning Zhang
    Department of Joint Surgery, the Affiliated Hospital of Tsingtao University, Tsingtao 266003, China
    Clin Orthop Relat Res 467:3175-82. 2009
    ..Within 10 days after transfection, the cytokine appears to be secreted into supernatants with the bioactivity and promotes the proliferation of the NIH 3T3 cell line...
  80. pmc The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling
    Jun Saegusa
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    J Biol Chem 284:24106-14. 2009
    ....
  81. doi Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men: results from the European Male Ageing Study
    John McBeth
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    J Rheumatol 36:2523-30. 2009
    ..To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men...
  82. doi IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling
    Vesna Furundzija
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Biochem Biophys Res Commun 394:786-91. 2010
    ..The aim of this study was to investigate the impact of IGF-1 on macrophage migration, its signaling pathways and the involvement of integrins and/or matrix metalloproteinases (MMPs)...
  83. ncbi Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer
    June M Chan
    Department of Epidemiology and Biostatistics and Urology, University of California at San Francisco, 94118, USA
    J Natl Cancer Inst 94:1099-106. 2002
    ....
  84. ncbi Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer
    Martha L Slattery
    Health Research Center, School of Medicine, University of Utah, Salt Lake City, 84108, USA
    Cancer Epidemiol Biomarkers Prev 13:1206-14. 2004
    ..We hypothesize that genetic polymorphisms of insulin receptor substrates (IRS-1 and IRS-2), IGF-I, and IGFBP-3 alter colorectal cancer risk because of their roles in the insulin-related signaling pathway...
  85. ncbi Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1
    Thomas Thum
    Universitat Wurzburg, Medizinische Klinik I Kardiologie, Wurzburg, Germany
    Circ Res 100:434-43. 2007
    ..Growth hormone-mediated increase in IGF-1 reverses age-related EPC dysfunction and may be a novel therapeutic strategy against vascular disorders with impairment of EPC...
  86. pmc Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies
    Wensen Chen
    Laboratory of Reproductive Medicine, Cancer Center, Nanjing Medical University, Nanjing, China
    Eur J Hum Genet 17:1668-75. 2009
    ..001). In conclusion, circulating levels of IGF1, IGFBP3 and IGFBP3 A-202C play a crucial role in carcinogenesis and could serve as susceptibility biomarkers for cancer development...
  87. pmc A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study
    Matthew C Kostek
    Department of Exercise Science, University of South Carolina, Columbia, SC, USA
    Eur J Appl Physiol 110:315-24. 2010
    ..Thus, in an elderly population but not a young population, a polymorphism in the IGF1 gene may be predictive of differences in body composition, primarily in black females...
  88. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
    ..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women...
  89. pmc Association of insulin-like growth factor-1 polymorphisms with high myopia in the Chinese population
    Wenjuan Zhuang
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing, China
    Mol Vis 18:634-44. 2012
    ..The purpose of this study was to determine whether genetic variants in the insulin-like growth factor-1 (IGF-1) gene were associated with high myopia in the Chinese population...
  90. ncbi Muscle strength response to strength training is influenced by insulin-like growth factor 1 genotype in older adults
    Matthew C Kostek
    Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
    J Appl Physiol (1985) 98:2147-54. 2005
    ..Thus these data suggest that the IGF1 promoter polymorphism may influence the strength response to ST. Larger sample sizes should be used in future studies to verify these results...
  91. ncbi Insulin-like growth factor pathway polymorphisms associated with body size in Hispanic and non-Hispanic white women
    Carol Sweeney
    Health Research Center, Family and Preventive Medicine, University of Utah, Suite A, 375 Chipeta Way, Salt Lake City, UT 84108, USA
    Cancer Epidemiol Biomarkers Prev 14:1802-9. 2005
    ..These results provide evidence that IGF pathway polymorphisms have functional effects on growth and central obesity and indicate that genotype-phenotype relationships are ethnic specific...
  92. ncbi Association between an IGF-I gene polymorphism and body fatness: differences between generations
    Paul G Voorhoeve
    Department of Pediatric Endocrinology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Eur J Endocrinol 154:379-88. 2006
    ..In this study, we investigated whether this polymorphism is associated with body composition in young healthy subjects in two cohorts of different generations...
  93. ncbi Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene
    K A Woods
    Department of Endocrinology, St Bartholomew s Hospital, London, United Kingdom
    N Engl J Med 335:1363-7. 1996
  94. ncbi Genetic factors related to racial variation in plasma levels of insulin-like growth factor-1: implications for premenopausal breast cancer risk
    H Jernstrom
    Centre for Research in Women s Health, University of Toronto, 790 Bay Street, 7th Floor, Toronto, Ontario, M5G 1N8, Canada
    Mol Genet Metab 72:144-54. 2001
    ..The high incidence of premenopausal breast cancer among black women may be mediated through genetic modifiers of circulating levels of IGF-I...
  95. ncbi A sequence repeat in the insulin-like growth factor-1 gene and risk of breast cancer
    Stacey A Missmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115 5804, USA
    Int J Cancer 100:332-6. 2002
    ..Although a modest association cannot be excluded, our data do not support an important relation between this IGF-1 gene polymorphism and breast cancer risk...
  96. ncbi Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women
    Anne R Cappola
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:2019-25. 2003
    ..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging...
  97. pmc Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding protein-3
    Thorsten Sadowski
    Institute of Biochemistry, Christian Albrechts University of Kiel, D 24118 Kiel, Germany
    Mol Biol Cell 14:4569-80. 2003
    ..This activity might have widespread consequences for the behavior of epidermal keratinocytes...
  98. pmc Insulin-like growth factor-1 prevents age-related decrease in specific force and intracellular Ca2+ in single intact muscle fibres from transgenic mice
    Estela Gonzalez
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Physiol 552:833-44. 2003
    ..Therefore, IGF-1 prevents age-related decline in peak intracellular Ca2+ and specific force in a muscle that does not exhibit changes in fibre type composition with senescence...
  99. ncbi Characterization of differentiated subcutaneous and visceral adipose tissue from children: the influences of TNF-alpha and IGF-I
    Malcolm Grohmann
    Department of Surgery, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom
    J Lipid Res 46:93-103. 2005
    ..Insulin-like growth factor binding protein-3 enhanced differentiation equally. These observations may have important physiological and pharmacological implications for the development of obesity in later life...
  100. pmc Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study
    F Canzian
    International Agency for Research on Cancer, Lyon, France
    Br J Cancer 94:299-307. 2006
    ..Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians...
  101. ncbi An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population
    Mojgan Yazdanpanah
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Cardiol 97:1274-6. 2006
    ..10 to 2.10, p = 0.02). The risk of death increased with the number of variant alleles. Our study suggests that genetically determined low IGF-I activity is an important determinant of mortality in subjects with MI...

Research Grants66

  1. CHRISTOPHER JOSEPH ROMERO; Fiscal Year: 2014
    ..These studies, moreover, will improve our understanding of the physiology of both normal and abnormal growth and the role of growth factors in regulating metabolism. ..
  2. Jill M Daniel; Fiscal Year: 2016
    ....
  3. Aging and IGF-1 Receptor in a three dimensional matrix
    Itay Bentov; Fiscal Year: 2013
    ..This is significant because understanding the basis of age-associated delayed wound healing could potentially offer novel therapeutic modalities. ..
  4. Jeffrey B Travers; Fiscal Year: 2016
    ..Furthermore, we will continue to evaluate the utility of prophylactic therapies that can prevent the occurrence of aging-associated photocarcinogenesis. ..
  5. PETER S ROTWEIN; Fiscal Year: 2014
    ....
  6. Thomas L Clemens; Fiscal Year: 2014
    ..These aims employ complementary genetic mouse models and their myoblasts to identify the mechanisms and of action of GH in skeletal muscle and distinguish effects of GH from those mediated by IGF-1. ..
  7. Physiologic Role of the Somatotroph IGF-1 Receptor
    Christopher Romero; Fiscal Year: 2009
    ..In the future, this may provide the basis for guidelines for the evaluation and treatment of children with growth disorders. ..
  8. C Ronald Kahn; Fiscal Year: 2016
    ....
  9. Akt/mTOR Signaling in Energy Balance Modulation of Epithelial Carcinogenesis
    Stephen D Hursting; Fiscal Year: 2013
    ..Furthermore, the proposed studies will establish molecular mechanisms underlying the anticancer effects of CR, especially in the putative target cells (i.e., stem cells) for cancer development. ..
  10. Vivek Bhalla; Fiscal Year: 2015
    ....
  11. Insulin and IGF-1 regulation of the GnR H neuron
    Sara A DiVall; Fiscal Year: 2012
    ..These studies will provide insight into how the brain's control of reproduction is affected by the nutrition dependent hormones insulin and insulin-like growth factor-1. ..
  12. Patrice Delafontaine; Fiscal Year: 2015
    ..These findings should allow development of innovative therapies targeted at reducing acute vascular events that are most often related to plaque instability. ..
  13. Derek LeRoith; Fiscal Year: 2016
    ....
  14. Adi Cohen; Fiscal Year: 2015
    ....
  15. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ....
  16. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..This proposal thus addresses important questions about how leptin can affect reproductive competence at the level of the pituitary. ..
  17. Anne Klibanski; Fiscal Year: 2015
    ..This proposal will examine possible therapeutic strategies to increase bone density and optimize peak bone mass in adolescents with anorexia nervosa. ..
  18. Epigenetic Actions of Growth Hormone
    Dennis J Chia; Fiscal Year: 2012
    ..The experiments of the proposal will provide key experimental tools and preliminary data for future research projects that will complete the transition to fully independent investigator status. ..
  19. Joshua M Hare; Fiscal Year: 2015
    ..This proposal has major implications for developing a promising new treatment strategy for the prevention and reversal of remodeling following MI. ..
  20. IGF-1 and Bone Loss in Women with Anorexia Nervosa
    Anne Klibanski; Fiscal Year: 2010
    ..abstract_text> ..
  21. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..Cachexia is also a complication of many other conditions including lung and heart disease and aging, the knowledge generated through this proposal also will help us in establishing new therapies for these conditions. ..
  22. IGF-1, oxidative stress and telomere dynamics in cultured human somatic cells
    Rivka C Stone; Fiscal Year: 2012
    ..Such information will be instrumental in designing preventive and therapeutic modalities to fight aging related diseases. ..
  23. MICHAL TOMASZ MARZEC; Fiscal Year: 2014
    ....
  24. Mild Cognitive Impairment: Cerebrovascular Dysfunction and Exercise Training
    Rong Zhang; Fiscal Year: 2012
    ..The new knowledge will have significant impact on prevention or treatment of AD. ..
  25. A non-secreted form of IGF-1 is a protective factor for neural stem cells
    ANTHONY JOHN WINDEBANK; Fiscal Year: 2012
    ..We propose to test the hypothesis that restoration of youthful levels of mechano growth factor (MGF) will arrest the decline in adult neurogenesis that is linked to loss of brain function in old ..
  26. Age-Dependent Regulation of Excitation-Contraction Coupling
    Osvaldo Delbono; Fiscal Year: 2013
    ..A better understanding of the decline in skeletal muscle molecular structure and function will allow more rationale interventions aimed at improving physical performance and independence in the elderly. ..
  27. Role of IGF-1R in breast cancer proliferation and survival via CYP1A1 epoxygenase
    MARIANGELLYS RODRIGUEZ; Fiscal Year: 2012
    ..The results will advance the breast cancer field by characterizing the biological mechanism by which the metabolism of dietary omega-3 fatty acids is regulated by insulin-like growth factors to promote the growth of breast cancer. ..
  28. Insulin-like Growth Factor 1 Vaccine for Cancer Prevention
    VICTOR RASO; Fiscal Year: 2009
    ..The cancer preventive action of these vaccines will be tested in several spontaneous tumor mouse strains. ..
  29. Role of Potent Trophic Factors on Glia and Motor Neurons in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..We will subsequently test the optimal combination of these factors using gene delivery in a rodent model of this devastating disease in order to define an optimal therapy for this debilitating disorder. ..
  30. Anthony W Ferrante; Fiscal Year: 2016
    ....
  31. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..The development of a viable non-toxic chemoprevention strategy targeting high risk women could have a significant impact on breast cancer morbidity and mortality. ..
  32. Henry J Thompson; Fiscal Year: 2016
    ..The data obtained has the potential to facilitate the translation of pre-clinical and clinical research to public health guidelines for PA directed to cancer prevention and control. ..
  33. The Organ Specific Role of Superoxide Dismutase in Sepsis
    Alix Ashare; Fiscal Year: 2010
    ..These studies have the potential to greatly impact the management of a complex disease which has a high mortality and, thus far, few therapeutic options which improve outcome. ..
  34. Jonathan Kipnis; Fiscal Year: 2016
    ....
  35. Receptor/Ligand Signals for Ovarian Follicular Angiogenesis
    Leon J Spicer; Fiscal Year: 2010
    ....
  36. Patrice Delafontaine; Fiscal Year: 2015
    ..These findings will allow development of innovative therapies to treat cachexia in chronic conditions in which the RAS is activated. ..
  37. Kurt H Albertine; Fiscal Year: 2015
    ..The significance of our proposal is that it has the potential to shift the paradigm about both the molecular and physiologic pathogenesis of neonatal CLD. ..
  38. Mechanisms of IGF-1 mediated rescue of radiation-induced salivary gland dysfuncti
    Kirsten H Limesand; Fiscal Year: 2012
    ..The studies could have the potential to prevent or restore salivary gland function to head and neck cancer patients. ..
  39. Nicholas M Boulis; Fiscal Year: 2014
    ..This study will provide the proof-of-principle data necessary to support future clinical trials of this approach. ..
  40. Preliminary Evaluation of FDG-PET with anti-IGF-1R Targeted Therapy in GISTs
    Margaret von Mehren; Fiscal Year: 2013
    ....
  41. A Chromosome 10 QTL Associated with IGF-1 and Bone Mass
    CLIFFORD JAMES ROSEN; Fiscal Year: 2010
    ..These studies will also determine how specific alleles in the Igfl gene affect critical post-transcriptional events that ultimately determine circulating levels of IGF-I. ..
  42. Insulin and growth factor signaling in the pituitary gonadotroph
    Ryan S Miller; Fiscal Year: 2012
    ....
  43. Regenerating the Heart with Engineered Human Cardiac Tissue
    KAREEN LOUISE KREUTZIGER COULOMBE; Fiscal Year: 2013
    ....
  44. Efficacy Of Metformin In The Methylnitrosourea-Induced Model Of ER
    Terisa Davis; Fiscal Year: 2013
    ..It is expected that these pre[unreadable] diabetic animal models will more closely approximate humans who consume high fat or high carbohydrate diets and who are more likely to use metformin. ..
  45. Obesity and Pancreatic Cancer: The Role of IGF-1
    Susan M Fischer; Fiscal Year: 2012
    ..This information should be useful in designing approaches or treatments that will counteract the effect of obesity on this very fatal human disease. ..
  46. H Kirk Hammond; Fiscal Year: 2015
    ..To develop and optimally refine this approach is the focus of this proposal. Insulin-like growth factor-I (IGFI) is a peptide with protean favorable cardiovascular effects (inotrope, angiogenic, anti-apoptotic)...
  47. The effect of childhood and lifetime obesity and colon carcinogenesis
    SUSAN ELIZABETH OLIVO-MARSTON; Fiscal Year: 2013
    ..This proposal has direct relevance to the mission of the National Cancer Institute in understanding both the cause, and potential ways to prevent, obesity-promoted colon cancer. ..
  48. Sergiy Sukhanov; Fiscal Year: 2014
    ..In addition, I anticipate that identification of molecular mechanisms regulating 12/15-LOX expression will offer new targets for therapeutic intervention. ..
  49. Alexander Kolevzon; Fiscal Year: 2015
    ....
  50. FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
    Terry J Smith; Fiscal Year: 2011
    ..We believe that insights gained from the proposed studies will enhance our understanding of potentially sight-threatening TAO and allow us to develop novel therapeutic approaches. ..
  51. Examination of Co-inheritance of Bone Mineral Density, IGF-1 and Lifespan
    Cheryl Ackert Bicknell; Fiscal Year: 2010
    ..Understanding the genetics of osteoporosis will lead to new and better treatments and improve our ability to screen for and prevent this common and debilitating disease. ..
  52. Salivary Acinar Cell Apoptosis: Regulation of p53 by Akt
    Steven M Anderson; Fiscal Year: 2010
    ..The development of a pre-clinical animal model that allows development of therapies that prevent irradiation-induced salivary gland dysfunction is great clinical significance to oral health. ..
  53. B George Barisas; Fiscal Year: 2014
    ....
  54. Insulin-like Growth Factor 1 Gene Therapy;Correction of Placental Insufficiency
    HELEN NICHOLA JONES; Fiscal Year: 2013
    ..Ultimately such knowledge has the potential to lead to the development of the first effective treatment for IUGR. ..
  55. Antonios G Mikos; Fiscal Year: 2014
    ....
  56. Kathryn E Saatman; Fiscal Year: 2015
    ..Ultimately our goal is to provide a catalyst to accelerate the translation of IGF-1 therapy into clinical application in order to improve the health and well-being of individuals burdened with TBI. ..
  57. JEFFREY SCOTT BURGDORF; Fiscal Year: 2016
    ..In humans, Insulin-like Growth Factor I (IGFI) has been shown to both increase positive affect and reduce symptoms of depression and anxiety, but peripheral side ..
  58. Linda K McLoon; Fiscal Year: 2015
    ..We will use our established methods to produce sensory-induced strabismus in infant monkeys, and then evaluate novel treatments employing growth factor treatments to correct eye misalignment. ..
  59. Neuroendocrine Mechanisms of Developmental Massage Therapy in Preterm Infants
    Laurie Moyer Mileur; Fiscal Year: 2009
    ....
  60. ANG II AND IGF-1 INTERACTION IN CARDIOVASCULAR TISSUE
    James Sowers; Fiscal Year: 2003
    ..Thus, the proposed investigation will explore the role of PI3-kinase in mediating the cardiovascular interactions of AngII/IGF-1 after both short-term in vitro Ang II exposure and longer-term in vivo Ang II tissue excess. ..
  61. FETAL BRANCHED CHAIN AMINO ACID AND KETOACID METABOLISM
    EDWARD LIECHTY; Fiscal Year: 2003
    ..abstract_text> ..
  62. IGF-I LEVELS, IGF-I GENOTYPE, AND PROSTATE CANCER
    Noel Weiss; Fiscal Year: 2002
    ..abstract_text> ..
  63. Tyrosine Phosphyorylation and Growth Hormone Signaling
    STUART FRANK; Fiscal Year: 2005
    ..These studies will significantly expand knowledge of GH and cytokine signaling and of biologicallyrelevant crosstalk between cytokine and growth factor signaling systems. ..
  64. PP4 and IGF-1 Signaling in Breast Tumorigenesis
    Tse Hua Tan; Fiscal Year: 2006
    ..These studies will provide new insight into the novel regulation of IGF-1 signaling by PP4 in breast cancer. Furthermore, this study may lead to the identification of PP4 as a novel target for breast cancer therapeutics. ..
  65. Mirk Kinase in Colon Cancer Development
    Eileen Friedman; Fiscal Year: 2005
    ..Aim 3 : measurement of mirk protein expression by immunohistochemistry in human cancer tissues. ..
  66. INSULIN-LIKE GROWTH FACTOR-1 STIMULATES CANCER INVASION
    Sandra Dunn; Fiscal Year: 2001
    ..These studies will provide important information on the regulation of breast cancer metastasis by IGF-1 signaling, which may ultimately lead to risk-reduction strategies either through changes in the diet or by antiestrogens. ..