IFI16

Summary

Gene Symbol: IFI16
Description: interferon gamma inducible protein 16
Alias: IFNGIP1, PYHIN2, gamma-interferon-inducible protein 16, interferon-gamma induced protein IFI 16, interferon-inducible myeloid differentiation transcriptional activator
Species: human

Top Publications

  1. ncbi A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells
    J A Trapani
    Austin Research Institute, Austin Hospital, Heidelberg, Australia
    Immunogenetics 36:369-76. 1992
  2. ncbi Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization
    J A Trapani
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Vic, Australia
    Immunogenetics 40:415-24. 1994
  3. ncbi The human interferon-inducible protein, IFI 16, is a repressor of transcription
    R W Johnstone
    The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australia
    J Biol Chem 273:17172-7. 1998
  4. ncbi The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations
    M J Dawson
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Australia
    J Leukoc Biol 64:546-54. 1998
  5. ncbi Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16
    R W Johnstone
    The Peter MacCallum Cancer Institute, Cancer Immunology Division, East Melbourne, Victoria, Australia
    Oncogene 19:6033-42. 2000
  6. ncbi IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway
    Yassine Amrani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1063-71. 2003
  7. ncbi Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16
    C J P Clarke
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 3002, Australia
    J Cell Biochem 89:80-93. 2003
  8. ncbi IFI16 as a negative regulator in the regulation of p53 and p21(Waf1)
    Jennifer C Kwak
    Hematology and Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:40899-904. 2003
  9. ncbi A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway
    Jason A Aglipay
    The Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Oncogene 22:8931-8. 2003
  10. ncbi Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation
    Nobuko Fujiuchi
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York University, One Gustave L Levy Place, New York, NY 10029, USA
    J Biol Chem 279:20339-44. 2004

Research Grants

  1. Katherine A Fitzgerald; Fiscal Year: 2016
  2. Divaker Choubey; Fiscal Year: 2015
  3. David M Knipe; Fiscal Year: 2014
  4. Role of IFI16 in Cellular Senescence
    Divaker Choubey; Fiscal Year: 2009
  5. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
  6. MATURATION OF HERPESVIRAL NUCLEAR PROTEINS
    David Knipe; Fiscal Year: 2003
  7. ENVELOPE GLYCOPROTEINS OF HHV8
    Bala Chandran; Fiscal Year: 2002
  8. Role of IFI 16 in Cellular Senescence and Aging
    Divaker Choubey; Fiscal Year: 2003
  9. Biology of HHV-8 interactions with host cells
    Bala Chandran; Fiscal Year: 2007
  10. Entry of HHV-8 Into the Target Cells
    Bala Chandran; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications128 found, 100 shown here

  1. ncbi A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells
    J A Trapani
    Austin Research Institute, Austin Hospital, Heidelberg, Australia
    Immunogenetics 36:369-76. 1992
    ..DNA blotting indicated that, in contrast to the mouse, IFI 16 is present as a single copy gene in the human genome...
  2. ncbi Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization
    J A Trapani
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Vic, Australia
    Immunogenetics 40:415-24. 1994
    The human IFI16 gene is a member of an interferon-inducible family of mouse and human genes closely linked on syntenic regions of chromosome 1...
  3. ncbi The human interferon-inducible protein, IFI 16, is a repressor of transcription
    R W Johnstone
    The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australia
    J Biol Chem 273:17172-7. 1998
    ..Thus, IFI 16 is a transcriptional repressor, with a modular structure typical of many known transcription regulators...
  4. ncbi The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations
    M J Dawson
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Australia
    J Leukoc Biol 64:546-54. 1998
    ..This differential expression of IFI 16 in myeloid precursor subpopulations and its perceived molecular properties are consistent with a possible role in regulating myelopoiesis...
  5. ncbi Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16
    R W Johnstone
    The Peter MacCallum Cancer Institute, Cancer Immunology Division, East Melbourne, Victoria, Australia
    Oncogene 19:6033-42. 2000
    ..These findings demonstrate a possible link between gene induction following interferon stimulation and p53-mediated cellular events...
  6. ncbi IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway
    Yassine Amrani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 284:L1063-71. 2003
    ....
  7. ncbi Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16
    C J P Clarke
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 3002, Australia
    J Cell Biochem 89:80-93. 2003
    ..These experiments define the transcriptional mechanisms of IFI 16 gene regulation and provide evidence suggesting that AP-1 activation may be an important event in IFN signaling...
  8. ncbi IFI16 as a negative regulator in the regulation of p53 and p21(Waf1)
    Jennifer C Kwak
    Hematology and Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:40899-904. 2003
    b>IFI16 is a member of the HIN-200 family (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) that contains a DNA binding domain, a transcriptional regulatory domain, and DAPIN/PAAD, a protein domain ..
  9. ncbi A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway
    Jason A Aglipay
    The Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Oncogene 22:8931-8. 2003
    We identified IFI16 as a BRCA1-associated protein involved in p53-mediated apoptosis. IFI16 contains the Pyrin/PAAD/DAPIN domain, commonly found in cell death-associated proteins...
  10. ncbi Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation
    Nobuko Fujiuchi
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York University, One Gustave L Levy Place, New York, NY 10029, USA
    J Biol Chem 279:20339-44. 2004
    b>IFI16 is a member of the PYRIN superfamily that has been implicated in BRCA1-mediated apoptosis and inflammation signaling pathways...
  11. ncbi Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells
    Francesca Gugliesi
    Department of Public Health and Microbiology, University of Turin, Via Santena 9, 10126 Torino, Italy
    J Leukoc Biol 77:820-9. 2005
    ..concentrations of H2O2 to p53 in primary human endothelial cells through the interferon (IFN)-inducible gene IFI16. Induction of IFI16 by H2O2 was concentration- and time-dependent (maximum at 50 microM, 6 h after treatment) and ..
  12. ncbi IFI16 in human prostate cancer
    Fatouma Alimirah
    Department of Radiation Oncology, Loyola University Chicago, Illinois, USA
    Mol Cancer Res 5:251-9. 2007
    Increased expression of IFI16 protein (encoded by the IFI16 gene) in normal human prostate epithelial cells is associated with cellular senescence-associated cell growth arrest...
  13. ncbi A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells
    Patrizia Caposio
    Department of Public Health and Microbiology, University of Turin, Turin 10126, Italy
    J Biol Chem 282:33515-29. 2007
    The human IFI16 gene is an interferon-inducible gene implicated in the regulation of endothelial cell proliferation and tube morphogenesis...
  14. ncbi Role of IFI16 in DNA damage and checkpoint
    Mutsuko Ouchi
    Department of Oncological Sciences, The Mount Sinai School of Medicine, New York University, New York, NY, USA
    Front Biosci 13:236-9. 2008
    b>IFI16 is a member of the HIN-200 family (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeat) that contains a DNA binding domain, a transcriptional regulatory domain, DAPIN/PAAD domain associated with ..
  15. ncbi Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37
    Hideyuki Tawara
    Department of Oncological Sciences, The Mount Sinai School of Medicine, New York University, New York, NY, USA
    Front Biosci 13:240-8. 2008
    Our previous results that IFI16 is involved in p53 transcription activity under conditions of ionizing radiation (IR), and that the protein is frequently lost in human breast cancer cell lines and breast adenocarcinoma tissues suggesting ..
  16. ncbi Interferon-inducible IFI16 protein in human cancers and autoimmune diseases
    Divaker Choubey
    Cincinnati VA Medical Center, OH, USA
    Front Biosci 13:598-608. 2008
    Interferon-inducible IFI16 protein (encoded by IFI16 gene located at 1q21 region) is a member of the p200-protein family...
  17. pmc Interferon-inducible Ifi200-family genes in systemic lupus erythematosus
    Divaker Choubey
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, P O Box 670056, Cincinnati, OH 45267, United States
    Immunol Lett 119:32-41. 2008
    ..of ISGs is the Ifi200-family, which includes mouse (Ifi202a, Ifi202b, Ifi203, Ifi204, and Ifi205) and human (IFI16, MNDA, AIM2, and IFIX) genes...
  18. doi Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53
    Lynda Li Song
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Mol Cancer Res 6:1732-41. 2008
    IFN-inducible IFI16 protein (encoded by IFI16 gene at 1q23.1) is the human member of the IFN-inducible structurally related p200 family proteins...
  19. doi In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16
    Jasenka Mazibrada
    Department of Public Health and Microbiology, Medical School of Turin, Via Santena 9, 10126 Turin, Italy
    Cancer Lett 287:33-43. 2010
    The Interferon-inducible gene, IFI16 has been implicated in the control of cell growth, apoptosis, angiogenesis and immunomodulation...
  20. doi Expression of the interferon-inducible proteins MxA and IFI16 in liver allografts
    Cinzia Borgogna
    DPMSC, Medical Liver Transplantation Unit, University of Udine, Udine, Italy
    Histopathology 54:837-46. 2009
    ..To test the hypothesis that the activation of the interferon (IFN) system pathways might link hepatitis C virus (HCV) recurrence in the liver allograft with acute cellular rejection...
  21. pmc Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene
    Lynda Li Song
    Department of Environmental Health, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e8569. 2010
    Increased levels of interferon (IFN)-inducible IFI16 protein (encoded by the IFI16 gene located at 1q22) in human normal prostate epithelial cells and diploid fibroblasts (HDFs) are associated with the onset of cellular senescence...
  22. doi Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma
    Feng Yu
    Institute of Life Sciences, Jiangsu University, Zhenjiang, China
    Liver Int 30:703-14. 2010
    ..Notably, dysregulation of DLK1 was found in some human hepatocellular carcinomas (HCC). However, the effect of DLK1 on HCC cell growth and its underlying mechanism are still largely unknown...
  23. doi The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity
    Francesca Gugliesi
    Department of Public Health and Microbiology, University of Turin, Via Santena 9, Turin, Italy
    J Autoimmun 35:114-23. 2010
    ..Autoantibodies against the Interferon-inducible IFI16 protein, a member of the HIN-200 family constitutively expressed in endothelial cells and keratinocytes, have been ..
  24. pmc Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein
    Ileana M Cristea
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    J Virol 84:7803-14. 2010
    ..We identified and confirmed the interaction of pUL83 with cellular IFI16 family members throughout the course of HCMV infection...
  25. pmc IFI16 is an innate immune sensor for intracellular DNA
    Leonie Unterholzner
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Nat Immunol 11:997-1004. 2010
    ..Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-β (IFN-β)...
  26. pmc Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53
    Jack C C Liao
    Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON M5G 2C4, Canada
    Structure 19:418-29. 2011
    b>IFI16 is a member of the interferon-inducible HIN-200 family of nuclear proteins...
  27. pmc Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts
    Xin Duan
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, Cincinnati, OH 45267, USA
    Mol Cancer Res 9:589-602. 2011
    The IFN-inducible IFI16 and AIM2 proteins act as innate immune sensors for cytosolic double-stranded DNA (dsDNA)...
  28. pmc IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway
    Xin Duan
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e19532. 2011
    ..Given that the activated p53 induces the expression of IFI16 protein, we investigated the potential role of the IFI16 protein in glucose restriction-induced responses.
  29. pmc IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
    Nagaraj Kerur
    H M Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Cell Host Microbe 9:363-75. 2011
    ..We demonstrate that during KSHV infection of endothelial cells, interferon gamma-inducible protein 16 (IFI16) interacts with the adaptor molecule ASC and procaspase-1 to form a functional inflammasome...
  30. pmc IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes
    Sudhakar Veeranki
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e27040. 2011
    ..Given that the IFI16 and AIM2 proteins are IFN-inducible and can heterodimerize with each other, we investigated the regulation of ..
  31. pmc The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication
    Grazia Rosaria Gariano
    Department of Public Health and Microbiology, University of Turin, Turin, Italy
    PLoS Pathog 8:e1002498. 2012
    Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA, modulates various cell functions, however, its role in regulating virus growth remains unresolved...
  32. doi Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation
    Yuudai Kondo
    Division of Oral and Maxillofacial Surgery, Medicine of Sensory and Motor Organs, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Cancer Sci 103:782-90. 2012
    ..These analyses indicated that the absent in melanoma 2 (AIM2) gene and the interferon-inducible gene 16 (IFI16) mapped to the hematopoietic interferon-inducible nuclear proteins...
  33. pmc Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
    Tengchuan Jin
    Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0430, USA
    Immunity 36:561-71. 2012
    ..AIM2 (absent in melanoma 2) and IFI16 (interferon-inducible protein 16) have been identified as DNA receptors that induce inflammasome formation and ..
  34. doi Preferential binding of IFI16 protein to cruciform structure and superhelical DNA
    Vaclav Brazda
    Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic
    Biochem Biophys Res Commun 422:716-20. 2012
    ..b>IFI16 has been identified as a target of IFNα and γ and is a member of the HIN-200 protein family...
  35. pmc Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
    Tuo Li
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 109:10558-63. 2012
    Detection of pathogenic nucleic acids is essential for mammalian innate immunity. IFN-inducible protein IFI16 has emerged as a critical sensor for detecting pathogenic DNA, stimulating both type I IFN and proinflammatory responses...
  36. pmc Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
    Megan H Orzalli
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:E3008-17. 2012
    ..We found that the interferon inducible protein 16 (IFI16) DNA sensor, which is required for induction of IRF-3 signaling in these cells, is nuclear, and its localization ..
  37. pmc Kaposi's sarcoma-associated herpesvirus latency in endothelial and B cells activates gamma interferon-inducible protein 16-mediated inflammasomes
    Vivek Vikram Singh
    H M Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    J Virol 87:4417-31. 2013
    ..of endothelial cells, acting as a nuclear pattern recognition receptor, gamma interferon-inducible protein 16 (IFI16) colocalized with the KSHV genome in the nuclei and interacted with ASC and procaspase-1 to form a functional ..
  38. pmc Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes
    Karen E Johnson
    H M Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    J Virol 87:5005-18. 2013
    ..Inflammasomes are comprised of cytoplasmic sensor molecules, such as NLRP3 and AIM2 or nuclear sensor IFI16, the adaptor protein ASC (apoptosis-associated speck-like protein containing CARD), and the effector protein ..
  39. pmc Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells
    Mairaj Ahmed Ansari
    H M Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois USA
    J Virol 87:8606-23. 2013
    ..association of a cytoplasmic sensor such as NLRP3 and AIM2 proteins or nuclear interferon-inducible protein 16 (IFI16) with adaptor ASC protein (apoptosis-associated speck-like protein with a caspase recruitment domain) and effector ..
  40. pmc The viral ubiquitin ligase ICP0 is neither sufficient nor necessary for degradation of the cellular DNA sensor IFI16 during herpes simplex virus 1 infection
    Delphine Cuchet-Lourenço
    MRC University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
    J Virol 87:13422-32. 2013
    The cellular protein IFI16 colocalizes with the herpes simplex virus 1 (HSV-1) ubiquitin ligase ICP0 at early times of infection and is degraded as infection progresses...
  41. pmc IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
    Martin R Jakobsen
    Department of Biomedicine and Aarhus Research Center for Innate Immunology, Aarhus University, 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 110:E4571-80. 2013
    ..This response was stimulated by stem regions in the DNA structure and was dependent on IFN-inducible protein 16 (IFI16), which bound immunostimulatory DNA directly and activated the stimulator of IFN genes -TANK-binding kinase 1 - ..
  42. pmc Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA
    Megan H Orzalli
    Departments of Microbiology and Immunobiology, and Medicine and Program in Virology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 110:E4492-501. 2013
    ..We have found that nuclear interferon (IFN)-inducible protein 16 (IFI16) acts as a restriction factor against ICP0-null herpes simplex virus 1 (HSV-1) to limit viral replication and ..
  43. pmc Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion
    Tuo Li
    Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
    Cell Host Microbe 14:591-9. 2013
    ..We establish that the interferon-inducible protein IFI16 acts as a nuclear DNA sensor following HCMV infection, binding viral DNA and triggering expression of antiviral ..
  44. pmc IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV
    Kathryn M Monroe
    Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA
    Science 343:428-32. 2014
    ..short hairpin RNA-mediated gene knockdown in primary CD4 T cells, we identify interferon-γ-inducible protein 16 (IFI16) as a host DNA sensor required for CD4 T cell death due to abortive HIV infection...
  45. doi Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1
    Hyun Jin Kang
    Authors Affiliations College of Pharmacy and Bio MAX institute, Research Institute of Pharmaceutical Sciences and College of Veterinary Medicine, BK21 Plus Program for Veterinary Science, Seoul National University, Seoul, Korea
    Cancer Res 74:1484-94. 2014
    ..encoding ERpro315 revealed that the transcription factor AP-2γ (TFAP2C) and the IFN-γ-inducible protein 16 (IFI16) were components of the complex...
  46. doi IFI16 mis-localization can be a contributing factor to hepatocellular carcinoma progression
    Xinli Shi
    Department of Pathobiology and Immunology, Hebei University of Traditional Chinese Medicine, Shijiazhuang, Hebei 050200, China Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Med Hypotheses 82:398-400. 2014
    ..However the mechanisms responsible for this phenomenon are poorly understood. Interferon-γ inducible protein 16 (IFI16), a multifunctional protein, has roles in anti-proliferation, autophagy, cell senescence, anti-inflammation, and ..
  47. pmc Innate nuclear sensor IFI16 translocates into the cytoplasm during the early stage of in vitro human cytomegalovirus infection and is entrapped in the egressing virions during the late stage
    Valentina Dell'Oste
    Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy
    J Virol 88:6970-82. 2014
    ..We recently demonstrated that the DNA sensor IFI16 restricts human cytomegalovirus (HCMV) replication by downregulating viral early and late but not immediate-early ..
  48. ncbi Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells
    Marisa Gariglio
    Department of Medical Sciences, Medical School, 28100 Novara, Italy
    J Interferon Cytokine Res 22:815-21. 2002
    This is the first description of an extensive immunohistochemical analysis of interferon (IFN)-inducible gene IFI16 expression in normal tissues...
  49. ncbi Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence
    Hong Xin
    Departments of Pathology and Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Mail Code 114B, Maywood, IL 60153, USA
    Oncogene 22:4831-40. 2003
    ..Collectively, our observations support the idea that increased levels of IFI 16 in PrECs contribute to senescence-associated irreversible cell growth arrest...
  50. ncbi IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells
    Eun Joo Kim
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Biol Chem 280:4913-20. 2005
    ..Here, we show that IFI16 is a necessary and sufficient downstream effector for LIF effects in MTC cells, specifically required for the LIF/..
  51. ncbi Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein
    Fatouma Alimirah
    Department of Radiation Oncology, Loyola University Chicago and Edward Hines Jr VA Hospital, 5th Avenue and Roosevelt Road, Building 1, Mail Code 114B, Hines, IL 60141, USA
    FEBS Lett 580:1659-64. 2006
    ..We report that re-expression of AR in PC-3 human prostate cancer cell line resulted in upregulation of IFI16 protein, a negative regulator of cell growth...
  52. doi Role of the interferon-inducible IFI16 gene in the induction of ICAM-1 by TNF-alpha
    Simone Sponza
    Department of Public Health and Microbiology, Medical School of Turin, Laboratory of Viral Pathogenesis, Turin, Italy
    Cell Immunol 257:55-60. 2009
    The Interferon-inducible gene IFI16, a member of the HIN200 family, is activated by oxidative stress and cell density, in addition to Interferons, and it is implicated in the regulation of endothelial cell proliferation and vessel ..
  53. ncbi Binding of an interferon-inducible protein (p202) to the retinoblastoma protein
    D Choubey
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520
    J Biol Chem 270:6134-40. 1995
    ..The hypophosphorylated form of pRb binds to p202, p202 is the first interferon-inducible protein found to bind pRb...
  54. doi IFI16 and NM23 bind to a common DNA fragment both in the P53 and the cMYC gene promoters
    Lorenza Egistelli
    Dipartimento di Scienze Biochimiche A Rossi Fanelli, Sapienza Universita di Roma, Roma, Italy
    J Cell Biochem 106:666-72. 2009
    ..2006] J. Cell. Biochem. 98:421-428). In a further study, we find now that IFI16, a transcriptional repressor, in both promoters binds to the G-rich fragment that also binds NM23/NDPK...
  55. doi The interferon-inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response
    Rossella Baggetta
    Department of Public Health and Microbiology, Medical School of Turin, Turin, Italy
    Eur J Immunol 40:2182-9. 2010
    The IFN-inducible human IFI16 gene is highly expressed in endothelial cells as well as epithelial and hematopoietic tissues...
  56. pmc Comparative analysis of transcriptional profiling of CD3+, CD4+ and CD8+ T cells identifies novel immune response players in T-cell activation
    Min Wang
    Interdepartmental Biological Sciences Program, Northwestern University, Evanston, IL, USA
    BMC Genomics 9:225. 2008
    ..Significantly, a comparative genome-scale transcriptional analysis of two T-cell subsets (CD4+ and CD8+) against each other and against the naturally mixed population (CD3+ cells) remains unexplored...
  57. doi Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR
    I Kimkong
    Medical Microbiology Interdisciplinary Program, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand
    Lupus 18:1066-72. 2009
    ..The expressions of MNDA, IFIX, IFI16 and AIM2 genes significantly increased in leukocytes but not in kidney biopsies from SLE patients as compared to ..
  58. pmc Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins
    Sudhakar Veeranki
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, PO Box 670056, Cincinnati, OH 45267, United States
    Immunol Lett 133:1-5. 2010
    ..In this review we discuss how increased levels of the p202 protein (and its human functional homologue IFI16 protein) in B cells increase lupus susceptibility and are likely to increase the risk of developing certain B cell ..
  59. pmc Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium
    Edward Chaum
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA
    Mamm Genome 26:210-21. 2015
    ..Importantly, we found an age-related increase in FCGR3A and FMN2 and a decrease in IFI16 levels in RPE cultures...
  60. pmc Interferon gamma-inducible protein 16 in primary Sjögren's syndrome: a novel player in disease pathogenesis?
    Alessia Alunno
    Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy
    Arthritis Res Ther 17:208. 2015
    ..The interferon-inducible IFI16 protein, normally expressed in cell nuclei, may be overexpressed, mislocalized in the cytoplasm and secreted in ..
  61. pmc Molecular characterization of woodchuck IFI16 and AIM2 and their expression in woodchucks infected with woodchuck hepatitis virus (WHV)
    Qi Yan
    Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Sci Rep 6:28776. 2016
    b>IFI16 and AIM2 are important DNA sensors in antiviral immunity...
  62. doi Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system
    Stefanie Luecke
    Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 4, 8000 Aarhus C, Denmark
    Cytokine . 2016
    ..Cytosolic RNA is recognized by RIG-I and MDA5, while intracellular DNA is sensed among others by cGAS, AIM2, IFI16 and RNA polymerase III...
  63. pmc Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
    Shruti Sharma
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Immunity 35:194-207. 2011
    ..type I IFNs via a pathway that did not involve the previously described sensors TLR9, DAI, RNA polymerase-III or IFI16/p204...
  64. pmc Association of social and cognitive impairment and biomarkers in autism spectrum disorders
    Altaf Alabdali
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    J Neuroinflammation 11:4. 2014
    ..between impaired levels of gamma aminobutyric acid (GABA), serotonin, dopamine, oxytocin, and interferon-γ-induced protein-16 (IFI16) and the severity of social and cognitive dysfunctions in individuals with autism spectrum disorders.
  65. pmc IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation
    Pier Paolo Piccaluga
    Department of Experimental, Diagnostic, and Specialty Medicine, Bologna University Medical School Unit of Hematopathology, S Orsola Malpighi Hospital, 40138 Bologna, Italy
    J Immunol Res 2015:747645. 2015
    The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation...
  66. doi New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16
    Xiangmin Ni
    Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming 650500, China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    J Mol Cell Biol 8:51-61. 2016
    Interferon gamma-inducible protein 16 (IFI16) senses DNA in the cytoplasm and the nucleus by using two tandem hematopoietic interferon-inducible nuclear (HIN) domains, HINa and HINb, through the cooperative assembly of IFI16 filaments on ..
  67. pmc The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking β-Catenin/TCF Regulated Transcription
    Wael M Abdel-Rahman
    Department of Medical Laboratory Sciences, College of Health Sciences and Sharjah Institute for Medical Research SIMR, University of Sharjah, P O Box 27272, Sharjah, UAE Department of Medical and Clinical Genetics, University of Helsinki, 00290 Helsinki, Finland
    Gastroenterol Res Pract 2016:6089658. 2016
    ..The immunohistochemistry of selected genes (IFI16, RGS4, MCTP1, DGKI, OBCAM/OPCML, and GLIPR1) confirmed that they were differentially expressed in clinical ..
  68. ncbi Innate DNA sensing moves to the nucleus
    Leonie Unterholzner
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Cell Host Microbe 9:351-3. 2011
    ..However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus (KSHV) is recognized inside the nucleus by the DNA sensor IFI16, leading inflammasome activation.
  69. pmc Nuclear DNA sensor IFI16 as circulating protein in autoimmune diseases is a signal of damage that impairs endothelial cells through high-affinity membrane binding
    Francesca Gugliesi
    Department of Public Health and Pediatric Sciences, University of Turin, Medical School, Turin, Italy
    PLoS ONE 8:e63045. 2013
    b>IFI16, a nuclear pathogenic DNA sensor induced by several pro-inflammatory cytokines, is a multifaceted protein with various functions...
  70. doi HPV16 activates the AIM2 inflammasome in keratinocytes
    M Reinholz
    Department of Dermatology and Allergy, Ludwig Maximilian University, Frauenlobstr 9 11, 80337, Munich, Germany
    Arch Dermatol Res 305:723-32. 2013
    ..Binding of viral DNA leads to AIM2 inflammasome activation and IL-1β release, while IFI16 activation results in IFN-β release...
  71. doi Staphylococcal enterotoxin C2 promotes osteogenesis and suppresses osteoclastogenesis of human mesenchymal stem cells
    Wei Ming Fu
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, PR China Guang zhou Institute of Advanced Technology, Chinese Academy of Sciences, PR China
    Exp Cell Res 322:202-7. 2014
    ..Interferon (IFN)-inducible gene IFI16, a co-activator of Runx2/Cbfa1, was also activated by SEC2 in the osteoblast differentiation...
  72. pmc Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling
    He Li
    MOE Key Laboratory of Protein Science and Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, People s Republic of China
    Acta Crystallogr F Struct Biol Commun 70:21-9. 2014
    ..Among them, AIM2 (absent in melanoma 2) and IFI16 (γ-interferon-inducible protein 16) recognize double-stranded DNA to initiate inflammatory responses...
  73. doi Cytosolic double-stranded DNA induces nonnecroptotic programmed cell death in trophoblasts via IFI16
    Xiao Chu
    Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China
    J Infect Dis 210:1476-86. 2014
    ..Moreover, the cell death in response to dsDNA was IFI16 dependent...
  74. doi IFI16: At the interphase between innate DNA sensing and genome regulation
    Martin R Jakobsen
    Department of Biomedicine, Aarhus University, Aarhus, Denmark Aarhus Research Center for Innate Immunology, Aarhus University, Aarhus, Denmark
    Cytokine Growth Factor Rev 25:649-55. 2014
    DNA carries the genetic code, and is also a potent stimulator of innate immune responses. IFI16 is a member of the family of PYHIN proteins and is composed of a PYRIN domain involved in homotypic protein-protein interactions and two HIN ..
  75. pmc An interleukin-1 beta-encoding retrovirus exhibits enhanced replication in vivo
    Edward P Browne
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Virol 89:155-64. 2015
    ..Although some retroviruses can trigger IL-1β secretion through the DNA-sensing molecule IFI16, the effect of IL-1β on the course of infection is unknown...
  76. pmc Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity
    David M Knipe
    Harvard Medical School, Department of Microbiology and Immunobiology, 77 Avenue Louis Pasteur, Boston, MA 02115, United States Electronic address
    Virology 479:153-9. 2015
    ..The cellular sensors that initiate the chromatinization of foreign DNA have not been fully defined. IFI16 and cGAS are both essential for innate sensing of HSV DNA, and new evidence shows how they work together to ..
  77. pmc The microarray gene profiling analysis of glioblastoma cancer cells reveals genes affected by FAK inhibitor Y15 and combination of Y15 and temozolomide
    Grace Huang
    Department of Surgical Oncology Roswell Park Cancer Institute, Buffalo, NY, 14263, USA
    Anticancer Agents Med Chem 14:9-17. 2014
    ..and temozolomide more significantly than by each agent alone were: COX7B; interferon, gamma-inducible transcript: IFI16; DDIT4; GADD45G and down-regulated: KIF3A, AKT1; ABL; JAK1, GLI3 and ALDH1A3...
  78. pmc Cell-to-Cell Transmission of HIV-1 Is Required to Trigger Pyroptotic Death of Lymphoid-Tissue-Derived CD4 T Cells
    Nicole L K Galloway
    Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA
    Cell Rep 12:1555-63. 2015
    ..The viral DNA is detected by the IFI16 sensor, leading to inflammasome assembly, caspase-1 activation, and the induction of pyroptosis, a highly ..
  79. doi DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota
    Si Ming Man
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    Pathog Dis 74:ftw028. 2016
    ..DNA and the DNA derivative RNA:DNA hybrids produced by bacteria, whereas the putative inflammasome sensor IFI16 responds to viral DNA in the nucleus...
  80. doi Neutrophil gene dynamics and plasma cytokine levels in dairy cattle during peri-implantation period
    Pasumarti Manjari
    Dairy Cattle Physiology Division, National Dairy Research Institute, Karnal, Haryana, India
    Vet Immunol Immunopathol 173:44-9. 2016
    ..of adhesion molecules (CD62L, CD11b), chemokine (IL-8), and interferon stimulated genes (ISG15, OAS1, MX1, MX2, IFI16 and IFI44) using qRT-PCR. Adhesion molecules along with IL-8 showed a higher expression in NP cows...
  81. pmc IFI16 Preferentially Binds to DNA with Quadruplex Structure and Enhances DNA Quadruplex Formation
    Lucia Hároníková
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65, Brno, Czech Republic
    PLoS ONE 11:e0157156. 2016
    Interferon-inducible protein 16 (IFI16) is a member of the HIN-200 protein family, containing two HIN domains and one PYRIN domain. IFI16 acts as a sensor of viral and bacterial DNA and is important for innate immune responses...
  82. pmc The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA
    Elizabeth E Gray
    Department of Immunology, University of Washington School of Medicine, Seattle, WA, 98195, USA
    Immunity 45:255-66. 2016
    ..Finally, CRISPR-mediated disruption of the human AIM2-like receptor IFI16 in primary fibroblasts revealed that IFI16 is not essential for the IFN response to human cytomegalovirus ..
  83. ncbi p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition
    B Datta
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 271:27544-55. 1996
    ..Expression of the 53BP1 segment binding to p202 overcame the inhibition by overexpressed p202 of the transcription of reporters mediated by the p53 or the AP-1 transcription factors and of the proliferation of yeast...
  84. ncbi Interferon-a sensitivity in melanoma cells: detection of potential response marker genes
    Ulrich Certa
    F Hoffmann La Roche Ltd, Pharmaceuticals Division, Basel, Switzerland
    Recent Results Cancer Res 160:85-91. 2002
    ..analysis of gene expression in either set of cell lines allowed the identification of four genes (RCCl, IFI16, hox2 and h19) preferentially transcribed in sensitive cells and two (SHB and PKC-zeta) preferentially expressed ..
  85. doi Biochemical regulation of the inflammasome
    Jennifer K Dowling
    Inflammation Research Group, School of Biochemistry and Immunology, Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Crit Rev Biochem Mol Biol 47:424-43. 2012
    ..Here, we review current knowledge surrounding the biochemical regulation of the NLRP1, NLRP3, NLRC4, AIM2 and IFI16 inflammasomes.
  86. doi Evidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau
    N Forde
    School of Agriculture and Food Science, University College Dublin, Belfield, Dublin, Ireland
    Physiol Genomics 44:799-810. 2012
    ..Quantitative real-time PCR analysis of selected genes revealed PARP12, ZNFX1, HERC6, IFI16, RNF213, and DDX58 expression increased in pregnant compared with cyclic endometria on day 16 and were directly ..
  87. pmc Gene expression profiling in dermatitis herpetiformis skin lesions
    M Dolcino
    Instituto Giannina Gaslini, Clinical Immunology Unit, 16148 Genoa, Italy
    Clin Dev Immunol 2012:198956. 2012
    ..In addition, gene modulation provides evidence for a local inflammatory response (IL8, PTGFR, FSTL1, IFI16, BDKRD2, and NAMPT) with concomitant leukocyte recruitment (CCL5, ENPP2), endothelial cell activation, and ..
  88. pmc DNA sensing-independent inhibition of herpes simplex virus 1 replication by DAI/ZBP1
    Thanh H Pham
    Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
    J Virol 87:3076-86. 2013
    ..Degradation of IFI16 and PML by ICP0 was enhanced in infection of DAI-knockdown cells...
  89. pmc Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors
    Kristy A Horan
    Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark
    J Immunol 190:2311-9. 2013
    ..Thus, proteasomal degradation of herpesvirus capsids releases DNA to the cytoplasm for recognition by DNA sensors...
  90. doi Anti-IFI16 antibodies and their relation to disease characteristics in systemic lupus erythematosus
    V Caneparo
    Department of Translational Medicine, Medical School of Novara, Italy
    Lupus 22:607-13. 2013
    Several studies have shown the presence of anti-IFI16 antibodies in systemic lupus erythematosus (SLE), Sjögren Syndrome (SjS), systemic sclerosis (SSc) and other autoimmune diseases...
  91. pmc Interferon Inducible IFI16 Expression in p16 Positive Squamous Cell Carcinoma of the Oropharynx
    Moriyasu Yamauchi
    Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    ISRN Otolaryngol 2013:263271. 2013
    ..However, the molecular basis of the responsiveness is unclear. Interferon inducible IFI16, which is implicated in the control of cell growth, apoptosis, angiogenesis, and immunomodulation in various types ..
  92. ncbi Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma
    K L DeYoung
    Laboratory of Cancer Genetics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Oncogene 15:453-7. 1997
    ..chromosome 1 (band q22) in a highly conserved region which also contains the known interferon-inducible genes IFI16 and MNDA. We have also demonstrated that, like IFI16 and MNDA, AIM2 is induced in HL60 cells by interferon gamma...
  93. ncbi Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing
    R W Johnstone
    The John Connell Laboratory, The Austin Research Institute, Heidelberg, Australia
    Biochemistry 37:11924-31. 1998
    ..Finally, IFI 16 isoforms can homo- and heterodimerize, and we have mapped the dimerization domain to the amino terminus which contains an imperfect leucine zipper domain...
  94. ncbi Cytoplasmic localization of the interferon-inducible protein that is encoded by the AIM2 (absent in melanoma) gene from the 200-gene family
    D Choubey
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Building No 1, 60153, Maywood, IL, USA
    FEBS Lett 474:38-42. 2000
    ..proteins is encoded by structurally related murine (Ifi202a, Ifi202b, Ifi203, Ifi204 and D3) and human (IFI16, MNDA and AIM2) genes...
  95. pmc High density oligonucleotide array analysis of interferon- alpha2a sensitivity and transcriptional response in melanoma cells
    U Certa
    Roche Genetics, F Hoffmann La Roche Ltd, Bau 93 610, Basel, 4070, Switzerland
    Br J Cancer 85:107-14. 2001
    ..The study of 4 sensitive and 2 resistant cell lines allowed the identification of 4 genes (RCC1, IFI16, hox2 and h19) preferentially transcribed in sensitive cells and 2 (SHB and PKC-zeta) preferentially expressed in ..
  96. pmc The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins
    Chuan Ju Liu
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8024, USA
    Mol Cell Biol 22:2893-905. 2002
    ....
  97. ncbi The interferon-inducible IFI16 gene inhibits tube morphogenesis and proliferation of primary, but not HPV16 E6/E7-immortalized human endothelial cells
    Ravera Raffaella
    Department of Public Health and Microbiology, University of Turin, Via Santena 9, 10126 Turin, Italy
    Exp Cell Res 293:331-45. 2004
    Immunohistochemical analysis has demonstrated that the human IFI16 gene, in addition to the hematopoietic tissues, is highly expressed in endothelial cells and squamous stratified epithelia...
  98. ncbi Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts
    Maria Rosa Bani
    Mario Negri Institute for Pharmacological Research, Bergamo and Milan, Italy
    Mol Cancer Ther 3:111-21. 2004
    ..fatty acid biosynthesis and sterol metabolism (FDPS, IDI1, LIPA, and SC5D), and IFN-mediated signaling (G1P3, IFI16, IFI27, IFITM1, and ISG15)...
  99. ncbi Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays
    Petra Håkansson
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Exp Hematol 32:476-82. 2004
    ..A wide range of signal transduction molecules are activated by BCR/ABL1, including MYC, PI-3 kinase, and different STAT molecules. In contrast, relatively few genes are known to be regulated by BCR/ABL1 at the level of transcription...
  100. pmc Identification of specific autoantigens in Sjögren's syndrome by SEREX
    Kazuo Uchida
    Second Department of Oral and Maxillofacial Surgery, Aichi Gakuin University School of Dentistry, Nagoya, Japan
    Immunology 116:53-63. 2005
    ..b>IFI16 and two kelch-like proteins, KLHL12 and KLHL7, were found to be novel autoantigens in SjS by SEREX...
  101. ncbi Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinoma
    Demetrius M Kokkinakis
    Department of Pathology, University of Pittsburgh, PA 15213 1863, USA
    Mol Cancer Ther 4:1338-48. 2005
    ..CLU, GADD45alpha, GADD45beta, and GADD45gamma and down-regulation of AURKB, TOP2A, CCNA, CCNB, PRC1, BUB1, NuSAP, IFI16, and BRCA1...

Research Grants10

  1. Katherine A Fitzgerald; Fiscal Year: 2016
    ..group has implicated the PYHIN family members Absent in melanoma-2 (AIM2) and the interferon-inducible protein (IFI16) as sensors of microbial DNA. Both proteins bind DNA via HIN domains...
  2. Divaker Choubey; Fiscal Year: 2015
    ..These proteins include NALP3 and the interferon (IFN) - inducible AIM2 and IFI16. Upon sensing cytosolic dsDNA, the AIM2 and NALP3 proteins recruit adaptor protein ASC to form an inflammasome, ..
  3. David M Knipe; Fiscal Year: 2014
    ..3. To define the effect of oral disease states on IFI16 nuclear sensing of HSV DNA...
  4. Role of IFI16 in Cellular Senescence
    Divaker Choubey; Fiscal Year: 2009
    ..The main objective of these proposed studies is to understand the molecular mechanisms by which IFI16 protein (encoded by the /F/76gene located at 1q22), an inducible transcriptional regulator, contributes to ..
  5. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
    ..Our studies will increase the understanding of the molecular basis of sex bias in lupus disease and could potentially lead to better diagnostic tools as well as disease monitoring, and effective treatments. 1 ..
  6. MATURATION OF HERPESVIRAL NUCLEAR PROTEINS
    David Knipe; Fiscal Year: 2003
    ..These studies should provide information that is important for designing antiviral strategies for HSV and for engineering HSV-2 strains for genital herpes vaccines. ..
  7. ENVELOPE GLYCOPROTEINS OF HHV8
    Bala Chandran; Fiscal Year: 2002
    ..1(A and B) and gB will lead into an important in sight into the development of future control measures. ..
  8. Role of IFI 16 in Cellular Senescence and Aging
    Divaker Choubey; Fiscal Year: 2003
    ..Importantly these studies will provide the preliminary data and evidence that we can perform these techniques for an R01 application. ..
  9. Biology of HHV-8 interactions with host cells
    Bala Chandran; Fiscal Year: 2007
    ..Further understanding of HHV-8-cell signaling will broaden our knowledge of HHV-8 related diseases and eventually lead to new anti-HHV-8 agents, and therapeutic agents against KS. ..
  10. Entry of HHV-8 Into the Target Cells
    Bala Chandran; Fiscal Year: 2009
    ..Further understanding of HHV-8-entry, integrin-dependent cell signaling pathways, and their role in infection would eventually lead to the development of new anti-HHV-8 agents. ..