ID2

Summary

Gene Symbol: ID2
Description: inhibitor of DNA binding 2, HLH protein
Alias: GIG8, ID2A, ID2H, bHLHb26, DNA-binding protein inhibitor ID-2, DNA-binding protein inhibitor ID2, cell growth-inhibiting gene 8, class B basic helix-loop-helix protein 26, helix-loop-helix protein ID2, inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, inhibitor of differentiation 2
Species: human

Top Publications

  1. ncbi A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development
    S Wang
    Stanford University School of Medicine, Department of Neurobiology, Sherman Fairchild Science Building D231, 299 Campus Drive, Stanford, CA 94305, USA
    Neuron 29:603-14. 2001
  2. ncbi Differential involvement of PU.1 and Id2 downstream of TGF-beta1 during Langerhans-cell commitment
    Leonhard X Heinz
    Institute of Immunology, Medical University Vienna, Lazarettgasse 19 A 1090 Vienna, Austria
    Blood 107:1445-53. 2006
  3. pmc Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes
    M E Massari
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    Mol Cell Biol 18:3130-9. 1998
  4. pmc Interleukin-1 beta-induced Id2 gene expression is mediated by Egr-1 in vascular smooth muscle cells
    Xiaojun Zhu
    Institute of Molecular Medicine, Peking University, No 5 Yi He Yuan Road, Beijing, 100871, PR China
    Cardiovasc Res 76:141-8. 2007
  5. pmc Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocyte
    M Moldes
    Universite Pierre et Marie Curie, UPRES A 7079 CNRS, Paris, France
    Biochem J 344:873-80. 1999
  6. pmc Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
    H F Yuen
    Department of Pathology, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Br J Cancer 97:1409-15. 2007
  7. ncbi The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein
    A Iavarone
    Preuss Laboratory, Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143
    Genes Dev 8:1270-84. 1994
  8. pmc Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins
    A Lasorella
    Preuss Laboratory for Molecular Neuro Oncology, Department of Neurological Surgery 94143, USA
    Mol Cell Biol 16:2570-8. 1996
  9. ncbi Differential interactions of Id proteins with basic-helix-loop-helix transcription factors
    K Langlands
    Section of Hematology Oncology, Children s Hospital of Pittsburgh, The, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 272:19785-93. 1997
  10. pmc Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors
    P R Yates
    Department of Biochemistry and Genetics, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH
    EMBO J 18:968-76. 1999

Research Grants

  1. Regulation of Natural Killer T cell maturation, homeostasis and activation
    LOUISE M D'CRUZ; Fiscal Year: 2012
  2. Regulation of Lymphocyte Development by HLH Proteins
    BARBARA LYNNE KEE; Fiscal Year: 2012
  3. Bonnie B Blomberg; Fiscal Year: 2014
  4. Towards a Mouse Model of Classical Hodgkin's Disease and PTLD
    FREDERICK WAYNE ALT; Fiscal Year: 2013
  5. Brigid L M Hogan; Fiscal Year: 2016
  6. Qihong Huang; Fiscal Year: 2014
  7. Role of Ovol Genes in Epidermal Development
    Xing Dai; Fiscal Year: 2010
  8. Matthias L Riess; Fiscal Year: 2014
  9. White matter injury in germinal matrix hemorrhage
    Praveen Ballabh; Fiscal Year: 2013
  10. COGNATE ACTIVATION OF B-LYMPHOCYTES
    Randolph J Noelle; Fiscal Year: 2013

Detail Information

Publications231 found, 100 shown here

  1. ncbi A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development
    S Wang
    Stanford University School of Medicine, Department of Neurobiology, Sherman Fairchild Science Building D231, 299 Campus Drive, Stanford, CA 94305, USA
    Neuron 29:603-14. 2001
    ..We show here that oligodendrocyte lineage cells express the helix-loop-helix proteins Mash1 and Id2. Although Mash1 has been found to regulate neuronal development, we found that in the absence of Mash1 ..
  2. ncbi Differential involvement of PU.1 and Id2 downstream of TGF-beta1 during Langerhans-cell commitment
    Leonhard X Heinz
    Institute of Immunology, Medical University Vienna, Lazarettgasse 19 A 1090 Vienna, Austria
    Blood 107:1445-53. 2006
    ..The transcription factors PU.1 and Id2 have been implicated as positive regulators of LC development from hematopoietic progenitor cells...
  3. pmc Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes
    M E Massari
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    Mol Cell Biol 18:3130-9. 1998
    ..ABF-1 represents the first example of a B-cell-restricted bHLH protein, and its expression pattern suggests that ABF-1 may play a role in regulating antigen-dependent B-cell differentiation...
  4. pmc Interleukin-1 beta-induced Id2 gene expression is mediated by Egr-1 in vascular smooth muscle cells
    Xiaojun Zhu
    Institute of Molecular Medicine, Peking University, No 5 Yi He Yuan Road, Beijing, 100871, PR China
    Cardiovasc Res 76:141-8. 2007
    b>Id2 (inhibitor of DNA-binding 2), a member of the helix-loop-helix family of transcription regulators, plays important roles in cell proliferation and differentiation...
  5. pmc Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocyte
    M Moldes
    Universite Pierre et Marie Curie, UPRES A 7079 CNRS, Paris, France
    Biochem J 344:873-80. 1999
    ..Gel mobility-shift assays performed with in vitro-translated ADD1, Id2 or Id3 proteins and a fatty acid synthase (FAS) promoter oligonucleotide showed evidence for a marked inhibition of ..
  6. pmc Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
    H F Yuen
    Department of Pathology, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Br J Cancer 97:1409-15. 2007
    ..Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients...
  7. ncbi The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein
    A Iavarone
    Preuss Laboratory, Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143
    Genes Dev 8:1270-84. 1994
    ..Our data identify a role for Id-2 in the regulation of cellular proliferation and suggest that the interaction between Id-2 and pRB is a molecular pathway over which synchronous changes in growth and differentiation are mediated in vivo...
  8. pmc Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins
    A Lasorella
    Preuss Laboratory for Molecular Neuro Oncology, Department of Neurological Surgery 94143, USA
    Mol Cell Biol 16:2570-8. 1996
    Cells which are highly proliferative typically lack expression of differentiated, lineage-specific characteristics. Id2, a member of the helix-loop-helix (HLH) protein family known to inhibit cell differentiation, binds to the ..
  9. ncbi Differential interactions of Id proteins with basic-helix-loop-helix transcription factors
    K Langlands
    Section of Hematology Oncology, Children s Hospital of Pittsburgh, The, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 272:19785-93. 1997
    Dimerization of three Id proteins (Id1, Id2, and Id3) with the four class A E proteins (E12, E47, E2-2, and HEB) and two groups of class B proteins, the myogenic regulatory factors (MRFs: MyoD, myogenin, Myf-5 and MRF4/Myf-6), and the ..
  10. pmc Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors
    P R Yates
    Department of Biochemistry and Genetics, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH
    EMBO J 18:968-76. 1999
    ..Therefore, our results demonstrate a novel facet of Id function in the coordination of mitogenic signalling and cell cycle entry...
  11. ncbi Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
    A Lasorella
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 407:592-8. 2000
    In mammalian cells, Id proteins coordinate proliferation and differentiation. Id2 is a dominant-negative antagonist of basic helix-loop-helix transcription factors and proteins of the retinoblastoma (Rb) family...
  12. ncbi Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation
    Annika Jögi
    Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
    J Biol Chem 277:9118-26. 2002
    ..We found that the three Id proteins expressed in neuroblastoma cells (Id1, Id2, and Id3) were down-regulated during induced differentiation, indicating that Id proteins help keep the tumor cells ..
  13. ncbi Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma
    Anna Lasorella
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:301-6. 2002
    Perturbation of the function of the retinoblastoma (Rb) protein is found in most human tumors. Id2 is a natural target of the Rb protein that is recruited by Myc oncoproteins to bypass the tumor suppressor function of Rb...
  14. ncbi The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors
    Hiroyuki Nishimori
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556, Japan
    Oncogene 21:8302-9. 2002
    We report here that the Id2 (inhibitor of DNA binding 2) gene is a novel target of transcriptional activation by EWS-FLI1 and EWS-ERG, two fusion proteins that characterize Ewing family tumors (EFTs)...
  15. ncbi Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma
    Mariko Fukuma
    Department of Pathology, Keio University School of Medicine, Tokyo, Japan
    Oncogene 22:1-9. 2003
    ..not in other tumor cell lines using the gene array technique, and found significantly enhanced expression of the Id2 gene. High levels of Id2 transcripts were detected in Ewing sarcoma cell lines and tumor tissues...
  16. ncbi Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells
    Yoko Itahana
    Cancer Research Institute, California Pacific Medical Center, Stern Building, 2230 Clay Street, San Francisco, CA 94115, USA
    Cancer Res 63:7098-105. 2003
    ....
  17. ncbi Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination
    Ifat Fajerman
    Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 31096 Haifa, Israel
    Biochem Biophys Res Commun 314:505-12. 2004
    ..Here, we demonstrate that the inhibitor of differentiation (or inhibitor of DNA binding) 2, Id2, that downregulates gene expression in undifferentiated and self-renewing cells, is degraded by the UPS following ..
  18. ncbi Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression
    Jean Philippe Coppe
    California Pacific Medical Center, Cancer Research Institute, San Francisco, California 94115, USA
    Clin Cancer Res 10:2044-51. 2004
    ..This study aimed to identify the potential role of Id-1 and Id-2 proteins as molecular makers for prostate cancer progression...
  19. ncbi Id2 is a primary partner for the E2-2 basic helix-loop-helix transcription factor in the human placenta
    Yi Ping Liu
    Wisconsin National Primate Research Center and the Department of Obstetrics and Gynecology, University of Wisconsin Medical School, Madison, WI 53715, USA
    Mol Cell Endocrinol 222:83-91. 2004
    We screened a term placental cDNA library by the yeast two-hybrid approach with Id2, a negative regulator of basic helix-loop-helix (bHLH) factors. Of the clones obtained, approximately one-third were the E2-2 bHLH transcription factor...
  20. pmc The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system
    Anna Lasorella
    Institute for Cancer Genetics, Department of Pathology, Pediatrics, and Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:4976-81. 2006
    b>Id2 is a natural inhibitor of the basic helix-loop-helix transcription factors and the retinoblastoma tumor suppressor protein...
  21. pmc E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells
    Gerson Rothschild
    Institute for Cancer Genetics, 1150 St Nicholas Ave, Columbia University, New York, NY 10032, USA
    Mol Cell Biol 26:4351-61. 2006
    ..Here we show that progression into S phase of human neuroblastoma cells is prevented by E proteins and promoted by Id2. Cyclin-dependent kinase inhibitors (CKI) have been identified as key effectors of cell cycle arrest in ..
  22. ncbi Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth
    Anna Lasorella
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 442:471-4. 2006
    In the developing nervous system, Id2 (inhibitor of DNA binding 2, also known as inhibitor of differentiation 2) enhances cell proliferation, promotes tumour progression and inhibits the activity of neurogenic basic helix-loop-helix (bHLH)..
  23. pmc Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma
    Christoph Renne
    Senckenberg Institute for Pathology, University of Frankfurt, Frankfurt
    Am J Pathol 169:655-64. 2006
    ..We show here that ID2, which can inactivate E2A and perhaps PAX5, is not detectable in normal B cells but is strongly and uniformly ..
  24. doi Decreased ID2 promotes metastatic potentials of hepatocellular carcinoma by altering secretion of vascular endothelial growth factor
    Ryouichi Tsunedomi
    Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Clin Cancer Res 14:1025-31. 2008
    We aimed to explore the molecular and biological functions of Inhibitor of DNA binding/differentiation 2 (ID2), which was found to be responsible for portal vein invasion of hepatocellular carcinoma (HCC).
  25. pmc Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver
    M J Gray
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 27:7192-200. 2008
    During development inhibitor of DNA-bind-2 (Id2) regulates proliferation and differentiation. Id2 expression has been detected in cancer cells, yet its cellular function and validity as a therapeutic target remains largely unknown...
  26. pmc A human Id-like helix-loop-helix protein expressed during early development
    J Biggs
    Preuss Laboratory for Molecular Neuro Oncology, Department of Neurological Surgery, School of Medicine, University of California, Box 0520, San Francisco 94143
    Proc Natl Acad Sci U S A 89:1512-6. 1992
    ..These findings suggest that Id-2 is an inhibitor of tissue-specific gene expression, although its distinctive pattern of expression during development suggests a role different from that of Id...
  27. ncbi Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts
    E Hara
    Department of Applied Biological Science, Science University of Tokyo, Noda, Japan
    J Biol Chem 269:2139-45. 1994
    ..SVts8 cells may acquire some function redundant to Id proteins. HT1080 fibrosarcoma cells expressed the Id-1H gene but not the Id-2H gene, suggesting these Id genes may subserve redundant functions...
  28. pmc Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding
    E C Roberts
    Department of Biochemistry and Genetics, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Mol Cell Biol 21:524-33. 2001
    ..Our results therefore demonstrate a novel facet of Id function in regulating cellular differentiation by functionally antagonizing the action of members of the Pax transcription factor family...
  29. pmc The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins
    Chuan Ju Liu
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8024, USA
    Mol Cell Biol 22:2893-905. 2002
    ..least in part, by overcoming the inhibition of the activities of the MyoD and E47 proteins by the Id proteins: Id1, Id2, and Id3...
  30. ncbi Transcriptional profiling identifies Id2 function in dendritic cell development
    Christine Hacker
    Max Delbruck Center for Molecular Medicine, MDC, Robert Rossle Str 10, 13092 Berlin, Germany
    Nat Immunol 4:380-6. 2003
    ..Here, we found that the helix-loop-helix transcription factor Id2 is up-regulated during DC development in vitro and crucial for the development of distinct DC subsets in vivo...
  31. ncbi Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation
    Bazarragchaa Damdinsuren
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Int J Oncol 26:319-27. 2005
    ..We examined the immunohistochemical expression of Id1, Id2 and Id3 proteins in 54 surgically resected HCCs with surrounding HCV or HBV-related chronic hepatitis (n=30) and ..
  32. ncbi Id2 reverses cell cycle arrest induced by {gamma}-irradiation in human HaCaT keratinocytes
    Sandrine Baghdoyan
    Service de Génomique Fonctionnelle, Commissariat à l Energie Atomique Evry, 2 rue Gaston Cremieux, CP22, 91057 Evry, France
    J Biol Chem 280:15836-41. 2005
    b>Id2 plays a key role in epithelial cells, regulating differentiation, the cell cycle, and proliferation...
  33. ncbi ID1 and ID2 are retinoic acid responsive genes and induce a G0/G1 accumulation in acute promyelocytic leukemia cells
    J Nigten
    Central Hematology Laboratory and Department of Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Leukemia 19:799-805. 2005
    ..Here we report the identification of two ATRA responsive genes in APL cells, ID1 and ID2. These proteins act as antagonists of basic helix-loop-helix (bHLH) transcription factors...
  34. ncbi Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2
    Xiaogang Li
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 7:1202-12. 2005
    ..Here, we show that the ADPKD protein polycystin-2 (PC2) regulates the cell cycle through direct interaction with Id2, a member of the helix-loop-helix (HLH) protein family that is known to regulate cell proliferation and ..
  35. pmc Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F
    Silvia Coma
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 70:3823-32. 2010
    ..It was found that Semaphorin 3F (SEMA3F), a potent inhibitor of metastasis, was repressed by Id2. High metastatic human tumor cell lines had relatively high amounts of Id2 and low SEMA3F levels compared with ..
  36. pmc Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors
    E Hara
    Imperial Cancer Research Fund Laboratories, London, UK
    EMBO J 16:332-42. 1997
    The helix-loop-helix (HLH) protein Id2 is thought to affect the balance between cell growth and differentiation by negatively regulating the function of basic-helix-loop-helix (bHLH) transcription factors...
  37. ncbi A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function
    J Liu
    Developmental Biology Program, Division of Pediatric Surgery, Childrens Hospital Los Angeles, University of Southern California, Keek School of Medicine, 4650 Sunset Boulevard, Los Angeles, California 90027, USA
    Biochem Biophys Res Commun 273:1042-7. 2000
    ..In this study, we compared the expression of Id2 mRNA in proliferating (fetal) and nonproliferating (adult) alveolar epithelial cells (AECs)...
  38. pmc Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1
    Han Jong Kim
    Hormone Research Center, Chonnam National University, Kwangju, 500 757, Republic of Korea
    Nucleic Acids Res 31:6860-72. 2003
    ..Our findings suggest that the E2A proteins differentially regulate the human and mouse SHP promoters and cooperate with orphan nuclear receptor SF-1 for transcriptional activation of the hSHP promoter...
  39. ncbi Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells
    Tobias Löfstedt
    Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
    J Biol Chem 279:39223-31. 2004
    ..expression of neuronal marker genes in neuroblastoma, but induces genes expressed in the neural crest, such as ID2. Because of its involvement in normal neural crest development and its ability to inhibit proneuronal bHLH proteins,..
  40. ncbi Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
    Miranda Buitenhuis
    Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands
    Blood 105:4272-81. 2005
    ..In this study, we have investigated the role of Id1 and Id2 in the regulation of granulopoiesis...
  41. ncbi Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    Y Yokota
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Nature 397:702-6. 1999
    ..Here we show that Id2 is indispensable for normal development of mice. Id2-/- mice lack lymph nodes and Peyer's patches...
  42. ncbi Safety profile of celecoxib as used in general practice in England: results of a prescription-event monitoring study
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, SO31 1AA, UK
    Eur J Clin Pharmacol 60:489-501. 2004
    ..A post-marketing surveillance study using the technique of Prescription Event Monitoring was undertaken to monitor the safety of celecoxib, a cyclo-oxygenase (COX)-2 inhibitor, as prescribed in primary care in England...
  43. pmc Accuracy of six commercially available systems for identification of members of the family vibrionaceae
    Caroline M O'Hara
    Division of Healthcare Quality Promotion, Epidemiology and Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:5654-9. 2003
    ..The products included API 20E, Crystal E/NF, MicroScan Neg ID2 and Rapid Neg ID3, and Vitek GNI+ and ID-GNB...
  44. ncbi Expression of MYCN in pediatric synovial sarcoma
    Gino R Somers
    Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada
    Mod Pathol 20:734-41. 2007
    ..of MCM7 (minichromosome maintenance protein 7) in all synovial sarcomas, and expression of nestin (n=10; 83%), ID2 (inhibitor of DNA binding protein 2) (n=6; 50%) and MRP1 (multidrug resistance protein 1) (n=1; 8%) in a subset of ..
  45. pmc Expression of myogenic regulatory factors in the muscle-derived electric organ of Sternopygus macrurus
    Jung A Kim
    Department of Biology, New Mexico State University, Las Cruces, NM 88003, USA
    J Exp Biol 211:2172-84. 2008
    ..Qualitative expression analysis of MRF co-regulators MEF2C, Id1 and Id2 also revealed these genes not to be unique to either muscle or EO, and detected similar expression patterns in the ..
  46. ncbi Comparative evaluation of two commercial chromogenic media for detection and presumptive identification of urinary tract pathogens
    C Scarparo
    Laboratory of Clinical Microbiology and Virology, S Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy
    Eur J Clin Microbiol Infect Dis 21:283-9. 2002
    ..commercial chromogenic media for the isolation and presumptive identification of urinary tract pathogens, the CPS ID2 (bioMérieux, France) and the CHROMagar Orientation (BBL Becton Dickinson, USA), was evaluated and compared with ..
  47. ncbi The Id2 transcriptional repressor is induced by follicle-stimulating hormone and cAMP
    M Joseph Scobey
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 279:16064-70. 2004
    ..Of the four characterized Id proteins, only Id2 is found in the nucleus of Sertoli cells that support the development of spermatozoa in the testis...
  48. ncbi Denervation stimulates apoptosis but not Id2 expression in hindlimb muscles of aged rats
    Stephen E Alway
    Laboratory of Muscle, Sarcopenia and Muscle Diseases, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown 26506 9227, USA
    J Gerontol A Biol Sci Med Sci 58:687-97. 2003
    ..To determine if Id2 proteins increase after denervation and if this is accompanied by increased apoptosis in aged as compared with ..
  49. pmc A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells
    Marc Jung
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 5:e10709. 2010
    ..associated with the cell cycle (CDKN1B, CDKN1C, CDK6 and MAPK4) and developmental processes (BMP4, HAND1, EOMES, ID2, GATA4, GATA5, ISL1 and MSX1)...
  50. ncbi Id2 expression during apoptosis and satellite cell activation in unloaded and loaded quail skeletal muscles
    Stephen E Alway
    Laboratory of Muscle, Sarcopenia and Muscle Diseases, Division of Exercise Physiology, West Virginia University School of Medicine, Robert C Byrd Health Science Center, Morgantown, West Virginia 26506, USA
    Am J Physiol Regul Integr Comp Physiol 284:R540-9. 2003
    Inhibitor of differentiation-2 (Id2) is a basic helix-loop-helix protein that acts as a negative regulator of the myogenic regulatory transcription factor family, but Id2 has also been implicated in apoptosis in several cell lines...
  51. pmc Regulation of Id2 expression by CCAAT/enhancer binding protein beta
    Kazuhiro Karaya
    Department of Molecular Genetics, School of Medicine, University of Fukui 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Nucleic Acids Res 33:1924-34. 2005
    Mice deficient for Id2, a negative regulator of basic helix-loop-helix (bHLH) transcription factors, exhibit a defect in lactation due to impaired lobuloalveolar development during pregnancy, similar to the mice lacking the CCAAT ..
  52. pmc Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration
    Jose L Rodriguez
    Departamento de Bioquimica y Biologia Molecular, Universidad de Valencia, Valencia, Spain
    Biochem J 398:431-7. 2006
    ..that the molecular mechanisms of liver regeneration are not completely understood prompted us to study the fate of Id2 in proliferating liver...
  53. ncbi Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
    Antonio Iavarone
    Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 432:1040-5. 2004
    ..Loss of Id2, a helix-loop-helix protein that mediates the lethality of Rb-deficient embryos, rescues the defects of Rb-..
  54. ncbi The helix-loop-helix inhibitor of differentiation (ID) proteins induce post-mitotic terminally differentiated Sertoli cells to re-enter the cell cycle and proliferate
    Jaideep Chaudhary
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 72:1205-17. 2005
    ..The four known helix-loop-helix ID proteins (i.e., Id1, Id2, Id3, and Id4) are considered dominant negative regulators of cellular differentiation pathways and act as positive ..
  55. pmc Modulation of retinal capillary endothelial cells by Müller glial cell-derived factors
    Hayato Abukawa
    Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Mol Vis 15:451-7. 2009
    ..The purpose of the present study was to identify genes of retinal capillary endothelial cells whose expression is modulated by Müller glial cell-derived factors...
  56. pmc Follicle-stimulating hormone (FSH) transiently blocks FSH receptor transcription by increasing inhibitor of deoxyribonucleic acid binding/differentiation-2 and decreasing upstream stimulatory factor expression in rat Sertoli cells
    Pushpa Viswanathan
    Department of Cell Biology and Physiology, Magee Women s Research Institute, University of Pittsburgh, Center for Research in Reproductive Physiology, Pittsburgh, Pennsylvania 15213, USA
    Endocrinology 150:3783-91. 2009
    ..Overexpression of ID2 resulted in a dose-dependent decrease in USF-driven Fshr promoter activity in the MSC-1 Sertoli cell line, and ID2 ..
  57. doi Loss of Id2 potentiates the tumorigenic effect of Rb inactivation in a mouse model of retinoblastoma
    Solange Landreville
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Eye Res 35:435-9. 2010
    ..retinoblastoma protein (Rb) appear to be mediated by unrestrained activity of the inhibitor of DNA binding protein Id2. The role of Id2 has not yet been investigated in the prototype cancer Rb-defective cancer, retinoblastoma itself...
  58. pmc Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats
    Kohji Kinoshita
    First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Gut 56:706-14. 2007
    ..Transforming growth factor-beta (TGFbeta) plays a pivotal role in extracellular matrix production, but bone morphogenetic protein (BMP)-7, a member of the TGFbeta superfamily, can antagonise the fibrogenic activity of TGFbeta...
  59. doi Molecular epidemiology of rabies in Indonesia
    Heru Susetya
    Department of Veterinary Medicine, Faculty of Applied Biological Sciences, The United School of Veterinary Sciences, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    Virus Res 135:144-9. 2008
    ..Rabies isolates in Indonesia were divided into three phylogroups (ID1, ID2 and ID3) that included seven lineages...
  60. ncbi A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis
    Guillermo Flores-Delgado
    Division of Hematology Oncology, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, 4650 Sunset Boulevard, Los Angeles, California 90027, USA
    J Proteome Res 6:1165-75. 2007
    ..confirmed by co-immunoprecipitation that 9 of these proteins associate with PP1: APAF-1, Bax, E-cadherin, HSP-70, Id2, p19Skp1, p53, PCNA, and PTEN. We examined two of these interactions in greater detail in A549 cells...
  61. doi Id2, Id3, and Id4 proteins show dynamic changes in expression during vibrissae follicle development
    Nigel L Hammond
    School of Biological and Biomedical Sciences, University of Durham, South Road, Durham, United Kingdom
    Dev Dyn 237:1653-61. 2008
    ..We studied Id2, Id3, and Id4 protein expression during different stages of rat vibrissa follicle development using ..
  62. pmc Suppression of chondrogenesis by Id helix-loop-helix proteins in murine embryonic orofacial tissue
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular Cellular and Craniofacial Biology, ULSD, University of Louisville, 501 S Preston Street, Suite 301, Louisville, KY 40292, USA
    Differentiation 77:462-72. 2009
    ..In the present study, the mRNA and protein expression patterns of Id1, Id2, Id3 and Id4 were examined in developing murine orofacial tissue in vivo, as well as in murine embryonic maxillary ..
  63. doi Upregulation of genes orchestrating keratinocyte differentiation, including the novel marker gene ID2, by contact sensitizers in human bulge-derived keratinocytes
    Yoshie Yoshikawa
    Department of Genetics, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    J Biochem Mol Toxicol 24:10-20. 2010
    ..Many genes orchestrating keratinocyte differentiation, including ID2, were significantly upregulated in response to the sensitizers in BDKs but not those in THP-1...
  64. pmc Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination
    Zhenming Xu
    Center for Immunology, School of Medicine and School of Biological Sciences, University of California, Irvine, CA 92697 4120, USA
    Crit Rev Immunol 27:367-97. 2007
    ..positively acting trans-factors, such as Pax5, HoxC4, E47, and Irf8, and negative modulators, such as Blimp1 and Id2, to restrict aicda expression primarily to germinal center B cells...
  65. ncbi Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti
    Jennifer M Jones
    Section on Developmental Neuroscience, Porter Neuroscience Center, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:550-8. 2006
    ..Results from PCR and in situ hybridization indicate that Id1, Id2, and Id3 are expressed within the cochlear duct in a pattern that is consistent with a role in regulation of hair ..
  66. ncbi Hormonal regulation and differential actions of the helix-loop-helix transcriptional inhibitors of differentiation (Id1, Id2, Id3, and Id4) in Sertoli cells
    J Chaudhary
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Endocrinology 142:1727-36. 2001
    ..Freshly isolated and cultured Sertoli cells coexpress all four isoforms of Id (Id1, Id2, Id3, and Id4), as determined by immunoprecipitation with isoform-specific anti-Id antibodies, RT-PCR, and Northern ..
  67. pmc Active gene repression by the Egr2.NAB complex during peripheral nerve myelination
    Gennifer M Mager
    Molecular and Cellular Pharmacology Training Program, Department of Comparative Biosciences, Graduate Program in Cellular and Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
    J Biol Chem 283:18187-97. 2008
    ..A screen for NAB-regulated genes identified several (including Id2, Id4, and Rad) that declined during the course of peripheral nerve myelination...
  68. doi Proper expression of helix-loop-helix protein Id2 is important to chondrogenic differentiation of ATDC5 cells
    Liu Yang
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, U S A
    Biochem J 419:635-43. 2009
    ..Inverse-PCR analysis of this clone revealed that the retroviral DNA was inserted into the promoter region of mouse Id2 (inhibitor of DNA-binding protein 2) gene...
  69. doi Id proteins facilitate self-renewal and proliferation of neural stem cells
    Seunghwan Jung
    Department of Anatomy, Ajou University, School of Medicine, Suwon, Gyeonggi Do, Korea
    Stem Cells Dev 19:831-41. 2010
    ..In this study, we show that Id1, Id2, and Id3 increase self-renewing and proliferation potential of cortical neural stem cells (NSCs) while inhibiting ..
  70. ncbi The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic development
    C H Biederer
    University of California, San Francisco, School of Medicine, Cancer Research Institute, San Francisco, California 94143 0128, USA
    J Biol Chem 275:26245-51. 2000
    ..assays indicated that overexpression of myogenin activates caveolin-3 reporter gene expression, whereas Id2 overexpression inhibited caveolin-3 promoter activation by myogenin...
  71. ncbi Id2 is dispensable for myc-induced lymphomagenesis
    Jonas A Nilsson
    Department of Biochemistry and the Animal Resource Center, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer Res 64:7296-301. 2004
    ..b>Id2, a negative regulator of basic helix-loop-helix transcription factors, has also been proposed as a Myc target gene ..
  72. ncbi Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans
    Yoshitaka Aoki
    Department of Molecular Genetics, School of Medicine, University of Fukui, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Genes Cells 9:1287-96. 2004
    ..Half of the cases are due to obstruction at the ureteropelvic junction (UPJ). Here we report that mice lacking Id2, an inhibitor of basic helix-loop-helix (bHLH) transcription factors, exhibit hydronephrosis mimicking the ..
  73. ncbi Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats
    Parco M Siu
    Laboratory of Muscle Biology and Sarcopenia, Division of Exercise Physiology, School of Medicine, Robert C Byrd Health Sciences Center, West Virginia Univ, Morgantown, WV 26506 9227, USA
    J Appl Physiol (1985) 100:907-16. 2006
    This study tested the hypothesis that inhibitor of differentiation-2 (Id2), p53, and heat shock proteins (HSP) are responsive to suspension-induced muscle atrophy...
  74. ncbi Expression, localization, and regulation of inhibitor of DNA binding (Id) proteins in the rat epididymis
    Michelle Carroll
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Androl 27:212-24. 2006
    ..The objectives of this study were to determine the mRNA expression and the immunocytolocalization of Id1, Id2, Id3, and Id4 in the epididymis of adult rats and to determine the Id3 protein expression profile in ..
  75. ncbi Analysis of vascular gene expression in arthritic synovium by laser-mediated microdissection
    Atsushi Hashimoto
    Department of Medicine and Rheumatology, Justus Liebig University of Giessen, Giessen, and University Hospital Regensburg, Germany
    Arthritis Rheum 56:1094-105. 2007
    ..The aim of this study was to analyze the specific synovial vascular expression profiles of several angiogenesis-related genes as well as CD82 in RA compared with osteoarthritis (OA), using laser-mediated microdissection (LMM)...
  76. ncbi Apoptosis and Id2 expression in diaphragm and soleus muscle from the emphysematous hamster
    Hans Degens
    Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Alsager Campus, Alsager, Cheshire, UK
    Am J Physiol Regul Integr Comp Physiol 293:R135-44. 2007
    ..apoptosis, and in the diaphragm and soleus also the expression of MyoD and inhibitor of differentiation protein 2 (Id2). There was no significant muscle atrophy in emphysematous hamsters...
  77. pmc Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer
    Erik Noetzel
    Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
    BMC Cancer 8:154. 2008
    ..ID4 has regulative functions for differentiation and growth of the developing brain. The role of ID1, ID2 and ID3 are expected to be oncogenic due to their overexpression in pancreatic cancer and colorectal ..
  78. pmc Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation
    Kye Won Park
    Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 22:2038-48. 2008
    ..Inhibitor of DNA biding 2 (Id2) was identified as a gene rapidly induced by harmine but not by PPARgamma agonists...
  79. ncbi [The effects of mycophenolate mofetil on renal interstitial fibrosis and epithelial-myofibroblast translation in adenine-induced renal failure rats]
    Chun mei He
    Division of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Nei Ke Za Zhi 47:901-5. 2008
    ..on epithelial-myofibroblast translation (EMT) in adenine-induced chronic renal failure (CRF) rat model and the role of vascular endothelial growth factor(VEGF) and inhibitor of differentiation (Id2 and Id3) in EMT in the rat kidney.
  80. doi Proliferative activity in vitro and DNA repair indicate that adult mouse and human Sertoli cells are not terminally differentiated, quiescent cells
    Emad A Ahmed
    Department of Endocrinology and Metabolism, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Biol Reprod 80:1084-91. 2009
    ..of the cell cycle inhibitor CDKN1B (P27(kip1)) and a 2-fold increase in the levels of the proliferation inducer ID2. In vivo, the balance between cell cycle inhibitors and inducers probably is such that the cells remain quiescent, ..
  81. doi Fibroblast growth factor 2 reactivates G1 checkpoint in SK-N-MC cells via regulation of p21, inhibitor of differentiation genes (Id1-3), and epithelium-mesenchyme transition-like events
    S Higgins
    Centre for Hormone Research, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville 3052, Victoria, Australia
    Endocrinology 150:4044-55. 2009
    ..Id1-3 expression was determined by RT2-PCR. FGF-2 induced Id2, while down-regulating Id1 and Id3...
  82. ncbi Gut-like structures from mouse embryonic stem cells as an in vitro model for gut organogenesis preserving developmental potential after transplantation
    Shigeko Torihashi
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Stem Cells 24:2618-26. 2006
    ..The results demonstrated that Id2-expressing epithelium developed first, alpha-smooth muscle actin appeared around the periphery, and finally, the ..
  83. ncbi IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice
    Tsunao Kishida
    Department of Microbiology, Kyoto Prefectural University of Medicine, Japan
    J Immunol 179:8554-61. 2007
    ..In the meanwhile, IL-21 provoked B cells in normal as well as allergic mice to express the inhibitor of differentiation 2 (Id2) gene that was shown to be crucially involved in the regulation of the activation-induced ..
  84. doi Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults
    Pierre Van Damme
    Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, Belgium
    Vaccine 27:454-9. 2009
    ..Intradermal vaccine delivery has been shown to induce good immune responses with low vaccine doses. Technologies for drug-delivery which specifically target the skin may render intradermal vaccination more accessible...
  85. doi TGF-beta induces growth arrest in Burkitt lymphoma cells via transcriptional repression of E2F-1
    Lindsay C Spender
    Growth Factor Signalling Laboratory, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, United Kingdom
    J Biol Chem 284:1435-42. 2009
    ..program in response to TGF-beta signaling involving the repression of the growth-promoting factors c-MYC, Id1, Id2, and Id3...
  86. pmc Phospho-ablated Id2 is growth suppressive and pro-apoptotic in proliferating myoblasts
    David C Butler
    Laboratory of Muscle Biology and Sarcopenia, Department of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia, United States of America
    PLoS ONE 4:e6302. 2009
    Inhibitor of differentiation protein-2 (Id2) is a dominant negative helix-loop-helix (HLH) protein, and a positive regulator of proliferation, in various cells...
  87. doi Id1, Id2 and Id3 are induced in rat melanotrophs of the pituitary gland by dopamine suppression under continuous stress
    H Konishi
    Department of Anatomy and Neurobiology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Neuroscience 169:1527-34. 2010
    ..RT-PCR, Western blotting and in situ hybridization confirmed the significant inductions of Id1, Id2 and Id3 in the IL of CS rats...
  88. doi Dynamic regulation of pituitary mRNAs for bone morphogenetic protein (BMP) 4, BMP receptors, and activin/inhibin subunits in the ewe during the estrous cycle and in cultured pituitary cells
    C Sallon
    Centre INRA de Tours, UMR85 Physiologie de la Reproduction et des Comportements, Nouzilly, France
    J Endocrinol 207:55-65. 2010
    ..quantitative reverse transcription-PCR, we showed that the levels of mRNA for BMP4, BMP receptor, the inhibitor of differentiation 2 (Id2), a target gene of BMP4, and noggin did not change significantly across the estrous cycle...
  89. doi Intestinal lineage commitment of embryonic stem cells
    Li Cao
    University of Connecticut, Department of Molecular and Cell Biology, 91 North Eagleville Road, Unit 3125 Storrs, CT 06269 3125, USA
    Differentiation 81:1-10. 2011
    ..5 (Sox17, Foxa2, and Gata4 expressed and Id2 silent)...
  90. ncbi TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient mice
    Takashi Kusunoki
    Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Allergy Clin Immunol 111:136-42. 2003
    ..Although the TH1/TH2 balance is important in many clinical situations, the regulatory mechanisms in vivo have not been well elucidated...
  91. ncbi Chromogenic in situ hybridization-detected hotspot MYCN amplification associates with Ki-67 expression and inversely with nestin expression in neuroblastomas
    Miikka Korja
    Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland
    Mod Pathol 18:1599-605. 2005
    ..with the prognosis (International Classification) and histological type, whereas the proliferation accelerator Id2 did not associate with any of the mentioned parameters...
  92. ncbi Hypoxia inhibits differentiation of lineage-specific Rcho-1 trophoblast giant cells
    Amy D Gultice
    Department of Neuroscience, Cell Biology, and Physiology, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45435, USA
    Biol Reprod 74:1041-50. 2006
    ..RT-PCR analysis revealed that undifferentiated Rcho-1 cells expressed trophoblast stem cell marker, Id2, and trophoblast giant cell markers...
  93. ncbi Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation
    D Glesne
    Argonne National Laboratory, Biosciences Division, Argonne, IL 60439 4803, USA
    Oncogene 25:4086-98. 2006
    ..demonstrate that during macrophage differentiation Smad6 displays an increased binding to the human osteopontin, Id2, and Hex gene promoters, which correlates to an observed increased expression of these genes...
  94. ncbi p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins
    Bo Ding
    Department of Molecular Biophysics and Biochemistry, Yale University, 333 Cedar Street, New Haven, CT 06520 8024, USA
    J Biol Chem 281:14893-906. 2006
    ..This was in consequence of the binding of Id1, Id2, or Id3 protein to the Gata4 and Nkx2...
  95. doi Dynamics of avian ovarian follicle development: cellular mechanisms of granulosa cell differentiation
    A L Johnson
    Department of Biological Sciences, The University of Notre Dame, P O Box 369, Notre Dame, IN 46556, USA
    Gen Comp Endocrinol 163:12-7. 2009
    ..Subsequent to follicle selection, cAMP-induced Id2 expression is considered both sufficient and necessary for fshr transcription...
  96. pmc TGF-beta repression of Id2 induces apoptosis in gut epithelial cells
    Y Cao
    Department of Surgery, University of Texas Health Science Center, Houston, TX 77030, USA
    Oncogene 28:1089-98. 2009
    ..Knockdown of Id1 and Id2 gene expression induced apoptosis in RIE-1 cells, whereas overexpression of Id2 attenuated TGF-beta-induced ..
  97. doi Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits
    Carlos I Lorda-Diez
    Departamento de Anatomia y Biologia Celular, Universidad de Cantabria, Santander 39011, Spain
    Int J Dev Biol 53:1495-502. 2009
    Here we report the pattern of expression of inhibitor of DNA binding/differentiation factor 2 (Id2) in the developing chicken limb...
  98. doi Identification of genes targeted by FSH and oocytes in porcine granulosa cells
    E J C Verbraak
    Department of Biochemistry and Cell Biology, Utrecht University, Yalelaan 2, 3584 CM Utrecht, The Netherlands
    Theriogenology 75:362-76. 2011
    ..Expression of inhibitor of DNA binding protein 2 and 3, ID2 and ID3, was decreased by FSH but increased by COCs, as validated by quantitative PCR...
  99. doi The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Bone 49:264-74. 2011
    ..Meanwhile, harmine remarkably promoted the expression of inhibitor of DNA binding/differentiation-2 (Id2), which is a negative regulator for osteoclastogenesis, in RAW264.7 cells and BMMs...
  100. doi Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis
    Tomoko Sakata-Goto
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Japan
    Bone 50:69-78. 2012
    ..the mechanisms required for maxillofacial morphogenesis, we employed the inhibitors of the differentiation 2 (Id2) knock-out mouse model, in which Id proteins, members of the regulator of basic helix-loop-helix (bHLH) ..
  101. doi Suppression of Src/ERK and GSK-3/β-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells
    Eun Jung Park
    College of Pharmacy, Ewha Womans University, Seoul 120 750, South Korea
    Food Chem Toxicol 55:424-33. 2013
    ..events led to the sequential downregulation of β-catenin-mediated transcription of target genes including BMP4, ID2, survivin, cyclin D1, MMP7, and c-Myc...

Research Grants51

  1. Regulation of Natural Killer T cell maturation, homeostasis and activation
    LOUISE M D'CRUZ; Fiscal Year: 2012
    ..transcription factor HEB is essential for NKT cell development and also showed that the transcriptional regulator Id2 controls survival of NKT cells in tissues such as lung and liver...
  2. Regulation of Lymphocyte Development by HLH Proteins
    BARBARA LYNNE KEE; Fiscal Year: 2012
    ..In Aim 1 of this grant application we propose experiments to test the hypothesis that Id2 and Id3 cooperate to promote NK cell development in the bone marrow and thymus...
  3. Bonnie B Blomberg; Fiscal Year: 2014
    ..E47, Id2, Notch, NFicB and AID expression in aged B cells will be characterized...
  4. Towards a Mouse Model of Classical Hodgkin's Disease and PTLD
    FREDERICK WAYNE ALT; Fiscal Year: 2013
    ..is dictated by the interference of certain transcription factors (TFs) known to be expressed in HRS cells, namely Id2, ABF1 and Notch1, with the B cell- specific gene expression program...
  5. Brigid L M Hogan; Fiscal Year: 2016
    ..For this aim we have already generated two new lines of genetically engineered mice, Id2-GFP and Id2-CreER...
  6. Qihong Huang; Fiscal Year: 2014
    ..We will determine the effect of Id2 and ARHGAP29, regulated by KLF17, individually and the combined effect of these two genes on tumor cell growth and ..
  7. Role of Ovol Genes in Epidermal Development
    Xing Dai; Fiscal Year: 2010
    ..We will perform biochemical studies to test the hypothesis that Ovol1 protein directly represses c-Myc and Id2 expression by competing with c-Myb for binding and by recruiting HDACs to their promoters, thereby facilitating ..
  8. Matthias L Riess; Fiscal Year: 2014
    ..to differences in endothelial NO synthase (eNOS) activity possibly modulated by the DNA-binding protein inhibitor Id2 and the peroxisome proliferator-activated receptor 3 (PPAR3). eNOS can produce NO or superoxide...
  9. White matter injury in germinal matrix hemorrhage
    Praveen Ballabh; Fiscal Year: 2013
    ..Oligodendrocyte (OL) development is regulated by transcription factors, including Olig-1, Olig-2, Mash 1, Id2, Id4, Nkx2...
  10. COGNATE ACTIVATION OF B-LYMPHOCYTES
    Randolph J Noelle; Fiscal Year: 2013
    ..survival;4) Shown that Bmem can be selectively primed relative to PCs, 5) Identified a lineage commitment factor, Id2, for Bmem, 6) Discounted the contribution of TLR stimulation in Bmem persistence and 7) Identified CCR6 as an ..
  11. GILES DUFFIELD; Fiscal Year: 2014
    ..Our preliminary studies reveal that Id genes are rhythmically expressed within the SCN and peripheral tissues;that Id2 null mice show circadian disorder phenotypes, including an enhanced speed of reentrainment of the clock following a ..
  12. The role of Id proteins in tumor development and angiogenesis in the brain
    Anna Lasorella; Fiscal Year: 2013
    ..All analyses described above were performed using tissues and cells from Id2 knockout mice in which the Id2 gene had been constitutively inactivated throughout embryogenesis...
  13. Xiaogang Li; Fiscal Year: 2016
    ..Furthermore, the following evidence supports the connection between TNF?? and Id2 signaling pathways: 1) TNF?? activates mTOR through IKK? and mTOR regulates the functional differentiation of ..
  14. RICARDO C AGUIAR; Fiscal Year: 2014
    ..targets the transcription factor SMAD5 and significantly impairs the TGF[unreadable]/BMP-mediated induction of ID2, a key negative regulator of the oncogeneic transcription factor PAX5...
  15. Boris Reizis; Fiscal Year: 2016
    ..but get diverted into a distinct "lymphocyte-like" state by the induction of E2-2 and repression of its inhibitor Id2. We will now characterize the specificity, mechanism and functional targets of E2-2 activity in the pDC lineage...
  16. Mechanisms and regulation of post-translational modifications of Id proteins
    Antonio Iavarone; Fiscal Year: 2012
    ..Recently, we discovered that colon cancer cells acquire a missense mutation in the Id2 gene that converts Threonine-27 into the unphosphorylatable amino acid Alanine...
  17. Prenatal ethanol exposure &neocortex, functional org. &gene expression
    KELLY HUFFMAN; Fiscal Year: 2013
    ..2004, Dye et al., 2011a, 2011b) we will identify early patterning of 7 genes, including RZR-ss, Id2, Cad8, Ephrin A5, Eph A7, COUP-TFI and Lhx2, in the neocortex of the PrEE mice...
  18. Inhibitor of Differentiation Gene Expression and Function in Prostate Cells
    Jaideep Chaudhary; Fiscal Year: 2013
    ..regulators, known to regulate all these processes, is the Inhibitor of differentiation (Id) protein (Id1, Id2, Id3 and Id4) family...
  19. The In Vivo Function of Id2 in Retinal Proliferation and Differentiation
    ROSA ANNA URIBE; Fiscal Year: 2011
    ..This will be accomplished by utilizing the zebrafish retina to understand the role of the intrinsic factor Id2 (Inhiibitor of Differentiation) in retinal development. The specific Aims of this proposal are 1...
  20. Tumor Suppressor and Oncogenic Pathways in the Placenta
    Lizhao Wu; Fiscal Year: 2007
    ..3. To examine the genetic regulatory networks employed by Rb in the placenta. E2F1, E2F2, E2F3, and Id2 can mediate Rb function in vivo, and concomitant genetic deletion of Rb and either of E2F1, E2F3, or Id2 can ..
  21. Function of Myeloid Translocation Gene Related-1
    SCOTT HIEBERT; Fiscal Year: 2009
    ..In addition, we found that the Tcf4-regulated genes c-Myc and Id2 were expressed at higher levels in Mtgr1-null mice, consistent with a role for Mtgr1 as a co-repressor that is ..
  22. MECHANISMS OF ID2-ENHANCED VASCULAR SMOOTH MUSCLE GROWTH
    Martin Matsumura; Fiscal Year: 2001
    ..The overall objective of the proposal is to determine the mechanisms through which Id2 enhances SMC growth and to identify the SMC factor(s) with which Id2 interacts to exert this effect...
  23. TRANSCRIPTIONAL REGULATORS OF CHONDROINDUCTION BY DBP
    Karen Yates; Fiscal Year: 2004
    ..genes of interest include transcription factors found to be changed by DBP on day 3 in our Preliminary Studies (ID2, FOG2, MBLL, HBP1), and transcription factors that are known to regulate embryonic chondrogenesis (SOX9, HOXC8, ..
  24. ROLE OF ID2 IN CRANIOFACIAL DEVELOPMENT
    Marianne Bronner Fraser; Fiscal Year: 2004
    ..First, we will explore the possible function of a helix-loop-helix transcriptional regulator, chick Id2, that is selectively expressed in the cranial but not the trunk neural folds...
  25. CELL SURVIVAL AND CANCER
    Bruno Calabretta; Fiscal Year: 2007
    ..the nucleus, the regulation of IRS-1 expression and promoter activity by IGF-1R and STAT-3, and the role of IRS-1, Id2, pRb, and STAT-3 in IGF-1-mediated regulation of apoptosis, proliferation and differentiation; iii) the pro-..
  26. Mechanisms Regulating Astroglial Lineage Development
    MARK MEHLER; Fiscal Year: 2006
    ..We have found that during both embryonic neurogenesis and gliogenesis, BMPs upregulate transcripts for ID2 and ID4 in NSCs and promote ID nuclear translocation in target progenitor species...
  27. Extracellular matrix and protease markers of malignant thyroid neoplasm
    Electron Kebebew; Fiscal Year: 2007
    ..We will use these results to design a multicenter clinical trial evaluating the diagnostic and prognostic value of ECM1 and TMPRSS4 expression in patients with thyroid neoplasm. [unreadable] [unreadable] [unreadable]..
  28. MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIA
    STEPHEN ALWAY; Fiscal Year: 2001
    ....
  29. The Role of Id2 in Adult Neurogenesis
    MATTHEW HAVRDA; Fiscal Year: 2008
    ..Recently, we have observed that while the brains of Id2 -/- mice appear to develop normally, adults have smaller olfactory bulbs...
  30. Id2 REGULATION OF MUSCLE HYPERTROPHY IN AGING
    STEPHEN ALWAY; Fiscal Year: 2007
    ..The overall goal of this proposal is to define cellular and molecular mechanisms of actions of Id2 in muscle growth in aging...
  31. Control of Vascular Smooth Muscle Function by Insulin
    Louis Ragolia; Fiscal Year: 2006
    ..abstract_text> ..
  32. Application for a Fluorescence-Activated Cell Sorter
    ELLEN ROTHENBERG; Fiscal Year: 2003
    ..This application is to replace the old sorter with a new sorter that will improve service to existing clients and permit the Facility to carry out new flow cytometric applications that have not been available to the user group before. ..
  33. DEVELOPMENT OF THE CORTICOTHALAMIC SYSTEM
    Edward Jones; Fiscal Year: 2003
    ..Defective maturation may be a concomitant of or a basis for certain forms of seizures in young individuals. ..
  34. PRODUCTION AND FUNCTION OF GHRH IN THE IMMUNE SYSTEM
    DOUGLAS WEIGENT; Fiscal Year: 2003
    ..It is further anticipated that the new understanding gained from the results will identify important sites for drug intervention against various immunodeficiencies including AIDS, autoimmunity, and aging. ..
  35. LINEAGE ANALYSIS OF FUNCTION IN MURINE LYMPHOCYTES
    ELLEN ROTHENBERG; Fiscal Year: 2004
    ....
  36. ACTIVITY-DEPENDENT PLASTICITY IN SENSORY CORTEX
    Edward Jones; Fiscal Year: 2004
    ....
  37. Modulation of EAE with ligand-activated NKT cells
    Luc Van Kaer; Fiscal Year: 2005
    ..These reagents will permit the selective activation of distinct adaptive immune responses in vivo, which could be exploited for therapeutic intervention in MS and other human autoimmune diseases. ..
  38. Akt Inhibitors to Treat Ewing's Sarcoma
    Jeffrey Toretsky; Fiscal Year: 2005
    ..Our findings from this Phase I Sun will hopefully lead to a key compound that can be further developed in a Phase II STTR ultimately leading to clinical trials in patients with ESFT. ..
  39. Modulation of type I diabetes with NKT cells
    Luc Van Kaer; Fiscal Year: 2006
    ..These studies will provide a better understanding of the immunological mechanisms that result in autoimmunity, and may lead to the development of novel agents for treatment of type I diabetes and other autoimmune diseases. ..
  40. Biacore T100
    Jeffrey Toretsky; Fiscal Year: 2006
    ..These enhanced capabilities of the T100 will allow projects investigating many types of biologic processes to advance. ..
  41. Signaling Pathways that Determine Ewings Sarcoma Outcome
    Jeffrey Toretsky; Fiscal Year: 2008
    ..Clearly, if PTPL1 is validated as a supportive oncoprotein and the pathways modulated by PTPL1 are identified, patients with many other tumors that rely on IGF-IR signaling including breast carcinoma could benefit from our findings. ..
  42. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2005
    ..It is envisioned that successful completion of this project will unveil potential therapeutic targets in the treatment of human leukemias characterized by the t(16;21) translocation. ..
  43. Somatic support cell function in gonad development
    GERRIT BOUMA; Fiscal Year: 2006
    ..The proposed experiments will identify genes expressed in gonadal SSCs that play a role in gonadal XY sex reversal. ..
  44. GATA-3 in precursor commitment to the T lineage
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..Definition of mechanistic requirements for GATA-3 perturbation of T-cell development 3. Attempted rescue of GATA-3 overexpression effects by cotransduction with targets of specific repression ..
  45. CIS-REGULATORY ANALYSIS OF PU.1 BY IN VITRO ES CELL DIFFERENTIATION
    ELLEN ROTHENBERG; Fiscal Year: 2007
    ..This should permit faster and cheaper experiments to reveal how powerful regulatory genes are themselves controlled. [unreadable] [unreadable]..
  46. CHONDROGENESIS AND HISTONE MODIFICATION ENZYMES
    Liu Yang; Fiscal Year: 2007
    ....
  47. Impact of Fli-1 expression on lupus disease development
    Xian Zhang; Fiscal Year: 2007
    ..Aim 2. Identify molecular mechanisms whereby Fli-1 affects the response of the kidney in MRUIpr mice to inflammatory stimuli. Aim 3. Determine effect of reduced expression of Fli-1 on disease development in NZM2410 mice. ..
  48. ID2 IN CELL CYCLE REGULATION AND CANCER
    Antonio Iavarone; Fiscal Year: 2010
    The Id2 protein has been implicated in a broad spectrum of cellular processes, including differentiation, cell cycle and tumor progression...
  49. ANALYSIS OF BIDIRECTIONAL SIGNALING MECHANISMS FOR BTLA AND HVEM IN AUTOIMMUNITY
    Kenneth M Murphy; Fiscal Year: 2010
    ..Importantly, BTLA has recently been reported to be involved in the susceptibility in humans to rheumatoid arthritis. Thus, our proposed studies into this newly identified but poorly understood molecule are particularly timely. ..
  50. A Screen for Mouse Cardiovascular Morphogenesis Mutants
    Ivan Moskowitz; Fiscal Year: 2008
    ..The candidate will combine clinical expertise with research training to pursue a career as a clinician-scientist in the field of cardiovascular morphogenesis and congenital heart disease. ..