Gene Symbol: HYMAI
Description: hydatidiform mole associated and imprinted (non-protein coding)
- A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZACT Arima
Wellcome CRC Institute of Cancer and Developmental Biology and Physiological Laboratory, University of Cambridge, United Kingdom
Genomics 67:248-55. 2000..Here we report the identification of a novel imprinted gene, HYMAI. This gene exhibits differential DNA methylation between the two parental alleles at an adjacent CpG island and is ..
- Transient neonatal diabetes mellitus type 1Deborah J G Mackay
University of Southampton, UK
Am J Med Genet C Semin Med Genet 154:335-42. 2010..It is caused by overexpression of the imprinted genes PLAGL1 and HYMAI on human chromosome 6q24...
- Construction of 700 human/mouse A9 monochromosomal hybrids and analysis of imprinted genes on human chromosome 6J Inoue
Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo
J Hum Genet 46:137-45. 2001..The paternal-specific expression of ZAC (zinc finger protein, which regulates apoptosis and cell cycle arrest) and HYMAI (hydatidiform mole-associated and imprinted transcript), and the maternal-specific methylation of a CpG island ..
- A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitusT Arima
Wellcome CRC Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
Hum Mol Genet 10:1475-83. 2001..TNDM patients exhibit paternal uniparental disomy (UPD) of chromosome 6q24, where at least two imprinted genes, HYMAI and ZAC, have so far been characterized...
- Establishment of the primary imprint of the HYMAI/PLAGL1 imprint control region during oogenesisT Arima
Division of Molecular and Cell Therapeutics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyusyu University, Kyusyu, Japan
Cytogenet Genome Res 113:247-52. 2006..two paternally expressed genes, the zinc finger protein gene PLAGL1 (ZAC/LOT1) and an untranslated mRNAcalled HYMAI. The putative IC overlaps exon 1 of HYMAI and is differentially methylated in somatic tissues...
- Genetic and epigenetic defects at the 6q24 imprinted locus in a cohort of 13 patients with transient neonatal diabetes: new hypothesis raised by the finding of a unique case with hemizygotic deletion in the critical regionC Diatloff-Zito
INSERM U781, Universite Paris 5, Paris, France
J Med Genet 44:31-7. 2007..It can be associated with chromosome 6 paternal uniparental disomy (UPD), paternal duplications or loss of maternal methylation at the 6q24 imprinted locus...
- Further refinement of the critical minimal genetic region for the imprinting disorder 6q24 transient neonatal diabetesL E Docherty
Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wiltshire, SP2 8BJ, UK
Diabetologia 53:2347-51. 2010..Transient neonatal diabetes (TND) is associated with overexpression of genes within a critical region on 6q24. This study aims to refine the boundaries of this region to reduce the number of potential candidate genes for 6q24 TND...
- Prenatal diagnosis of trisomy 6 rescue resulting in paternal UPD6 with novel placental findingsMariana M Cajaiba
Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania, USA
Am J Med Genet A 155:1996-2002. 2011..of paternal UPD6 results from biallelic expression of the maternally imprinted, paternally expressed ZAC and HYMAI genes, and includes transient neonatal diabetes mellitus (TNDM), intra-uterine growth restriction (IUGR), ..
- Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loopIsabel Iglesias-Platas
Servicio de Neonatologia, Hospital Sant Joan de Déu HSJD, Fundació Sant Joan de Déu, 08950 Barcelona, Spain
Nucleic Acids Res 41:2171-9. 2013Paternal duplications of chromosome 6q24, a region that contains the imprinted PLAGL1 and HYMAI transcripts, are associated with transient neonatal diabetes mellitus...
- Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitusD J G Mackay
Wessex Regional Genetics Laboratory, Salisbury District Hospital, Wiltshire, UK
Hum Genet 110:139-44. 2002..Two genes partially overlap the island: the cell-cycle-control gene ZAC and the untranslated gene HYMAI, the function of which is currently unknown...
- Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDMDan Ma
Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
J Clin Invest 114:339-48. 2004..of one or both genes within the TNDM locus: ZAC, which encodes a proapoptotic zinc finger protein, and HYMAI, which encodes an untranslated mRNA...
- Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approachAnna L Gloyn
Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK
Diabetes 55:2272-6. 2006..Using a study sufficiently powered to detect odds ratios of <1.2, we conclude that common variation in the TNDM region does not play an important role in the genetic susceptibility to type 2 diabetes...
- The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in miceTakahiro Arima
Division of Molecular and Cell Therapeutics, Department of Molecular Genetics, Kyusyu University, Beppu, Oita 874 0838, Japan
Genomics 88:650-8. 2006..Two paternally expressed human genes, HYMAI and PLAGL1 (LOT1/ZAC), are located within human chromosome 6q24...