HYMAI

Summary

Gene Symbol: HYMAI
Description: hydatidiform mole associated and imprinted (non-protein coding)
Alias: NCRNA00020
Species: human

Top Publications

  1. ncbi A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC
    T Arima
    Wellcome CRC Institute of Cancer and Developmental Biology and Physiological Laboratory, University of Cambridge, United Kingdom
    Genomics 67:248-55. 2000
  2. doi Transient neonatal diabetes mellitus type 1
    Deborah J G Mackay
    University of Southampton, UK
    Am J Med Genet C Semin Med Genet 154:335-42. 2010
  3. ncbi Construction of 700 human/mouse A9 monochromosomal hybrids and analysis of imprinted genes on human chromosome 6
    J Inoue
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo
    J Hum Genet 46:137-45. 2001
  4. ncbi A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus
    T Arima
    Wellcome CRC Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
    Hum Mol Genet 10:1475-83. 2001
  5. ncbi Establishment of the primary imprint of the HYMAI/PLAGL1 imprint control region during oogenesis
    T Arima
    Division of Molecular and Cell Therapeutics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyusyu University, Kyusyu, Japan
    Cytogenet Genome Res 113:247-52. 2006
  6. pmc Genetic and epigenetic defects at the 6q24 imprinted locus in a cohort of 13 patients with transient neonatal diabetes: new hypothesis raised by the finding of a unique case with hemizygotic deletion in the critical region
    C Diatloff-Zito
    INSERM U781, Universite Paris 5, Paris, France
    J Med Genet 44:31-7. 2007
  7. doi Further refinement of the critical minimal genetic region for the imprinting disorder 6q24 transient neonatal diabetes
    L E Docherty
    Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wiltshire, SP2 8BJ, UK
    Diabetologia 53:2347-51. 2010
  8. doi Prenatal diagnosis of trisomy 6 rescue resulting in paternal UPD6 with novel placental findings
    Mariana M Cajaiba
    Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania, USA
    Am J Med Genet A 155:1996-2002. 2011
  9. pmc Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop
    Isabel Iglesias-Platas
    Servicio de Neonatologia, Hospital Sant Joan de Déu HSJD, Fundació Sant Joan de Déu, 08950 Barcelona, Spain
    Nucleic Acids Res 41:2171-9. 2013
  10. ncbi Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus
    D J G Mackay
    Wessex Regional Genetics Laboratory, Salisbury District Hospital, Wiltshire, UK
    Hum Genet 110:139-44. 2002

Scientific Experts

  • T Arima
  • D J G Mackay
  • Catherine Diatloff-Zito
  • L E Docherty
  • Isabel Iglesias-Platas
  • Mariana M Cajaiba
  • Anna L Gloyn
  • Dan Ma
  • Amy Guillaumet-Adkins
  • Alex Martin-Trujillo
  • Franck Court
  • David Monk
  • Andrea Riccio
  • Angela Sparago
  • Cristina Camprubí
  • Gudrun E Moore
  • J Inoue
  • Selma Witchel
  • Jaqueline Hoover
  • Lori Hoffner
  • Suneeta Madan-Khetarpal
  • Trevor Macpherson
  • Urvashi Surti
  • Andrew T Hattersley
  • Timothy M Frayling
  • Mark I McCarthy
  • Graham Hitman
  • Bridget A Knight
  • Katharine R Owen
  • Michael N Weedon
  • Mark Walker
  • Claude Knauf
  • Gavin Kelsey
  • Wendy Dean
  • R éMy Burcelin R
  • Isabelle Leclerc
  • Julian P H Shield
  • Guy A Rutter
  • K Mitsuya
  • M Kadota
  • K Yamauchi
  • S Maegawa
  • T C Schulz
  • S Nishihara
  • T Shinohara
  • D Okamura
  • S Takehara
  • M Oshimura
  • H Kugoh

Detail Information

Publications14

  1. ncbi A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC
    T Arima
    Wellcome CRC Institute of Cancer and Developmental Biology and Physiological Laboratory, University of Cambridge, United Kingdom
    Genomics 67:248-55. 2000
    ..Here we report the identification of a novel imprinted gene, HYMAI. This gene exhibits differential DNA methylation between the two parental alleles at an adjacent CpG island and is ..
  2. doi Transient neonatal diabetes mellitus type 1
    Deborah J G Mackay
    University of Southampton, UK
    Am J Med Genet C Semin Med Genet 154:335-42. 2010
    ..It is caused by overexpression of the imprinted genes PLAGL1 and HYMAI on human chromosome 6q24...
  3. ncbi Construction of 700 human/mouse A9 monochromosomal hybrids and analysis of imprinted genes on human chromosome 6
    J Inoue
    Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo
    J Hum Genet 46:137-45. 2001
    ..The paternal-specific expression of ZAC (zinc finger protein, which regulates apoptosis and cell cycle arrest) and HYMAI (hydatidiform mole-associated and imprinted transcript), and the maternal-specific methylation of a CpG island ..
  4. ncbi A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus
    T Arima
    Wellcome CRC Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
    Hum Mol Genet 10:1475-83. 2001
    ..TNDM patients exhibit paternal uniparental disomy (UPD) of chromosome 6q24, where at least two imprinted genes, HYMAI and ZAC, have so far been characterized...
  5. ncbi Establishment of the primary imprint of the HYMAI/PLAGL1 imprint control region during oogenesis
    T Arima
    Division of Molecular and Cell Therapeutics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyusyu University, Kyusyu, Japan
    Cytogenet Genome Res 113:247-52. 2006
    ..two paternally expressed genes, the zinc finger protein gene PLAGL1 (ZAC/LOT1) and an untranslated mRNAcalled HYMAI. The putative IC overlaps exon 1 of HYMAI and is differentially methylated in somatic tissues...
  6. pmc Genetic and epigenetic defects at the 6q24 imprinted locus in a cohort of 13 patients with transient neonatal diabetes: new hypothesis raised by the finding of a unique case with hemizygotic deletion in the critical region
    C Diatloff-Zito
    INSERM U781, Universite Paris 5, Paris, France
    J Med Genet 44:31-7. 2007
    ..It can be associated with chromosome 6 paternal uniparental disomy (UPD), paternal duplications or loss of maternal methylation at the 6q24 imprinted locus...
  7. doi Further refinement of the critical minimal genetic region for the imprinting disorder 6q24 transient neonatal diabetes
    L E Docherty
    Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, Wiltshire, SP2 8BJ, UK
    Diabetologia 53:2347-51. 2010
    ..Transient neonatal diabetes (TND) is associated with overexpression of genes within a critical region on 6q24. This study aims to refine the boundaries of this region to reduce the number of potential candidate genes for 6q24 TND...
  8. doi Prenatal diagnosis of trisomy 6 rescue resulting in paternal UPD6 with novel placental findings
    Mariana M Cajaiba
    Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania, USA
    Am J Med Genet A 155:1996-2002. 2011
    ..of paternal UPD6 results from biallelic expression of the maternally imprinted, paternally expressed ZAC and HYMAI genes, and includes transient neonatal diabetes mellitus (TNDM), intra-uterine growth restriction (IUGR), ..
  9. pmc Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop
    Isabel Iglesias-Platas
    Servicio de Neonatologia, Hospital Sant Joan de Déu HSJD, Fundació Sant Joan de Déu, 08950 Barcelona, Spain
    Nucleic Acids Res 41:2171-9. 2013
    Paternal duplications of chromosome 6q24, a region that contains the imprinted PLAGL1 and HYMAI transcripts, are associated with transient neonatal diabetes mellitus...
  10. ncbi Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus
    D J G Mackay
    Wessex Regional Genetics Laboratory, Salisbury District Hospital, Wiltshire, UK
    Hum Genet 110:139-44. 2002
    ..Two genes partially overlap the island: the cell-cycle-control gene ZAC and the untranslated gene HYMAI, the function of which is currently unknown...
  11. pmc Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM
    Dan Ma
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    J Clin Invest 114:339-48. 2004
    ..of one or both genes within the TNDM locus: ZAC, which encodes a proapoptotic zinc finger protein, and HYMAI, which encodes an untranslated mRNA...
  12. ncbi Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach
    Anna L Gloyn
    Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK
    Diabetes 55:2272-6. 2006
    ..Using a study sufficiently powered to detect odds ratios of <1.2, we conclude that common variation in the TNDM region does not play an important role in the genetic susceptibility to type 2 diabetes...
  13. ncbi The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice
    Takahiro Arima
    Division of Molecular and Cell Therapeutics, Department of Molecular Genetics, Kyusyu University, Beppu, Oita 874 0838, Japan
    Genomics 88:650-8. 2006
    ..Two paternally expressed human genes, HYMAI and PLAGL1 (LOT1/ZAC), are located within human chromosome 6q24...