HTR3C

Summary

Gene Symbol: HTR3C
Description: 5-hydroxytryptamine receptor 3C
Alias: 5-hydroxytryptamine receptor 3C, 5-HT3-C, 5-HT3C, 5-hydroxytryptamine (serotonin) receptor 3, family member C, 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic, 5-hydroxytryptamine receptor 3 subunit C, serotonin receptor 3C
Species: human

Top Publications

  1. doi Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy
    P A Fasching
    University Breast Center Franconia, Erlangen University Hospital, Universitaetsstrasse 21 23, Erlangen, Bavaria, Germany
    J Cancer Res Clin Oncol 134:1079-86. 2008
  2. pmc ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma
    Monisha E Nongpiur
    Singapore Eye Research Institute and Singapore National Eye Centre, Singapore
    PLoS Genet 10:e1004089. 2014
  3. doi Association between variants of 5-hydroxytryptamine receptor 3C (HTR3C) and chemotherapy-induced symptoms in women receiving adjuvant treatment for breast cancer
    Dorit Pud
    Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel
    Breast Cancer Res Treat 144:123-31. 2014
  4. doi 5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strase 25, DE 53105 Bonn, Germany Electronic address
    Eur Neuropsychopharmacol 24:86-94. 2014
  5. doi The Human Serotonin Type 3 Receptor Gene (HTR3A-E) Allelic Variant Database
    Jacopo Celli
    Center of Human and Clinical Genetics, Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands
    Hum Mutat 38:137-147. 2017
  6. pmc A mega-analysis of genome-wide association studies for major depressive disorder
    Stephan Ripke
    Harvard University Broad Institute, USA
    Mol Psychiatry 18:497-511. 2013
  7. doi Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response
    Zhi Xu
    Department of Neuropsychiatry, Zhongda Hospital, Medical School, Southeast University, Nanjing, China
    J Psychopharmacol 26:349-59. 2012
  8. doi Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy
    Tamme W Goecke
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany
    Acta Obstet Gynecol Scand 89:7-14. 2010
  9. doi Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients
    P Klepstad
    Pain and Palliation Research Group, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway
    Pain 152:1139-45. 2011
  10. pmc Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E
    Johannes Kapeller
    Department of Human Molecular Genetics, University of Heidelberg, Germany
    J Comp Neurol 519:420-32. 2011

Scientific Experts

  • L Lennertz
  • John A Peters
  • Pål Klepstad
  • Peter Andreas Fasching
  • Beate Niesler
  • Michael B Ward
  • Gudrun A Rappold
  • Karola Rehnstrom
  • Jacopo Celli
  • Dorit Pud
  • Monisha E Nongpiur
  • Stephan Ripke
  • Zhi Xu
  • Johannes Kapeller
  • Marcella Rietschel
  • Wolfgang Maier
  • Tamme W Goecke
  • Nicholas M Barnes
  • Anna Schuhmacher
  • Alla M Karnovsky
  • Masako Kuroda
  • Vernon K Y Yong
  • Donald T Tan
  • Saleh A Al-Obeidan
  • Gil Har-Zahav
  • Do Nhu Hon
  • Takanori Mizoguchi
  • Victor H K Yong
  • Raghavan Lavanya
  • Sarah Ben-Ami
  • Ching Lin Ho
  • Michael A Hauser
  • Hailin Meng
  • Ningli Wang
  • Yik Ying Teo
  • R Rand Allingham
  • Serena M L Ting
  • Yasuo Kurimoto
  • Seng Chee Loon
  • E Shyong Tai
  • Chi Pui Pang
  • Naushin Waseem
  • Seang Mei Saw
  • Eranga N Vithana
  • Guangxian Tang
  • Li Jia Chen
  • Hon Tym Wong
  • Jost B Jonas
  • Yael Laitman
  • Tran Nguyen Bich Chau
  • Chunyan Qiao
  • Vedam L Ramprasad
  • Jin Xin Bei
  • Sancy Low
  • Paul J Foster
  • Do Tan
  • Yi Xin Zeng
  • Mingzhi Zhang
  • Chiea Chuen Khor
  • Ya Xing Wang
  • Lingam Vijaya
  • Azhany Yaakub
  • K Saidas Nair
  • Balekudaru Shantha
  • Liza Sharmini A Tajudin
  • Shamira A Perera
  • Yang Li
  • Tami Rubinek
  • Tina T Wong
  • Bo Feng
  • Essam A Osman
  • Ying Feng Zheng
  • Sujie Fan
  • Hongyan Jia
  • Cameron P Simmons
  • Kee Seng Chia
  • Shomi S Bhattacharya
  • Clement C Y Tham
  • Simon W M John
  • Tin Aung
  • Alicia C How
  • Ching Yu Cheng
  • Eitan Friedman
  • Daniel H Su
  • Govindasamy Kumaramanickavel
  • Ileana Soto
  • Ido Wolf
  • Zvi Symon
  • Mineo Ozaki
  • Belinda K Cornes

Detail Information

Publications20

  1. doi Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy
    P A Fasching
    University Breast Center Franconia, Erlangen University Hospital, Universitaetsstrasse 21 23, Erlangen, Bavaria, Germany
    J Cancer Res Clin Oncol 134:1079-86. 2008
    ..Y129S (HTR3B), p.K163N (HTR3C) and p.A405G (HTR3C)...
  2. pmc ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma
    Monisha E Nongpiur
    Singapore Eye Research Institute and Singapore National Eye Centre, Singapore
    PLoS Genet 10:e1004089. 2014
    ..30, P = 7.45 × 10(-9); 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions...
  3. doi Association between variants of 5-hydroxytryptamine receptor 3C (HTR3C) and chemotherapy-induced symptoms in women receiving adjuvant treatment for breast cancer
    Dorit Pud
    Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel
    Breast Cancer Res Treat 144:123-31. 2014
    ..and rs8007267), catecholamine-o-methyltransferase (COMT, rs4818), and 5-hydroxytryptamine (serotonin) receptor 3C (HTR3C, rs6766410, and rs6807362)...
  4. doi 5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strase 25, DE 53105 Bonn, Germany Electronic address
    Eur Neuropsychopharmacol 24:86-94. 2014
    ..024). In male subjects, the variant rs6766410 (p.N163K) located in the HTR3C was significantly associated with OCD (p=0.007)...
  5. doi The Human Serotonin Type 3 Receptor Gene (HTR3A-E) Allelic Variant Database
    Jacopo Celli
    Center of Human and Clinical Genetics, Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands
    Hum Mutat 38:137-147. 2017
    ..receptors are ligand-gated ion channels formed by five subunits (5-HT3A-E), which are encoded by the HTR3A, HTR3B, HTR3C, HTR3D, and HTR3E genes. Functional receptors are pentameric complexes of diverse composition...
  6. pmc A mega-analysis of genome-wide association studies for major depressive disorder
    Stephan Ripke
    Harvard University Broad Institute, USA
    Mol Psychiatry 18:497-511. 2013
    ..The 3p21.1 MDD-BIP finding should be interpreted with caution as the most significant SNP did not replicate in MDD samples, and genotyping in independent samples will be needed to resolve its status...
  7. doi Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response
    Zhi Xu
    Department of Neuropsychiatry, Zhongda Hospital, Medical School, Southeast University, Nanjing, China
    J Psychopharmacol 26:349-59. 2012
    ..nucleotide polymorphisms (SNPs) in coding regions of 10 serotonergic genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, HTR3C, HTR3D, HTR3E, HTR5A and TPH2) were genotyped in 308 Chinese Han patients with major depressive disorder...
  8. doi Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy
    Tamme W Goecke
    Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany
    Acta Obstet Gynecol Scand 89:7-14. 2010
    ..To assess the association between pregnancy-associated symptoms and common single nucleotide polymorphisms (SNPs) in genes known to be involved in the pathogenesis of nausea and vomiting...
  9. doi Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients
    P Klepstad
    Pain and Palliation Research Group, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway
    Pain 152:1139-45. 2011
    ..OPRK1, ARRB2, GNAZ, HINT1, Stat6, ABCB1, COMT, HRH1, ADRA2A, MC1R, TACR1, GCH1, DRD2, DRD3, HTR3A, HTR3B, HTR2A, HTR3C, HTR3D, HTR3E, HTR1, or CNR1 showed significant associations with opioid dose in both the development and the ..
  10. pmc Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E
    Johannes Kapeller
    Department of Human Molecular Genetics, University of Heidelberg, Germany
    J Comp Neurol 519:420-32. 2011
    ....
  11. doi A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Eur Neuropsychopharmacol 20:414-20. 2010
    ..This study provides additional evidence for a role of the serotonergic system and the 5-HT3 receptor in schizophrenia...
  12. ncbi Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E
    Beate Niesler
    Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, 69120, Heidelberg, Germany
    Gene 310:101-11. 2003
    ..polymerase chain reaction and fluorescence in situ hybridisation revealed that both genes together with HTR3C are clustered in a subinterval of less than 100 kb on chromosome 3q27...
  13. doi Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009
    ..Moreover, many antipsychotic drugs are antagonists at 5-HT3 receptors. However, the role of 5-HT3 receptor variants on response to antipsychotic drugs in schizophrenic patients is still unclear...
  14. pmc Allelic variants in HTR3C show association with autism
    Karola Rehnstrom
    Department of Molecular Medicine, National Public Health Institute and Institute for Molecular Medicine Finland, Helsinki, Finland
    Am J Med Genet B Neuropsychiatr Genet 150:741-6. 2009
    ..The most significant association was observed using two non-synonymous SNPs in HTR3C, rs6766410 and rs6807362, both resulting in P = 0.0012 in family-based association analysis...
  15. doi The 5-HT3 receptor--the relationship between structure and function
    Nicholas M Barnes
    Cellular and Molecular Neuropharmacology Research Group, Department of Pharmacology, Division of Neuroscience, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Neuropharmacology 56:273-84. 2009
    ..5-HT3A and 5-HT3B subunits are well established components of 5-HT3 receptors but additional HTR3C, HTR3D and HTR3E genes expand the potential for molecular diversity within the family...
  16. doi Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy
    Michael B Ward
    Sansom Institute, University of South Australia, Frome Road, Adelaide, Australia
    Pharmacogenomics 9:1027-33. 2008
    ..Chemotherapy-induced nausea and vomiting is a significant clinical problem. The 5HT(3) receptor antagonists are effective anti-emetic medications but approximately 30% of patients do not respond...
  17. doi Serotonin type 3 receptor genes: HTR3A, B, C, D, E
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Pharmacogenomics 9:501-4. 2008
    ..different human subunits are known, 5-HT(3AE), which are encoded by the serotonin receptor genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E, respectively. Functional receptors are pentameric complexes of diverse composition...
  18. ncbi Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Mol Pharmacol 72:8-17. 2007
    ..After our discovery of further putative 5-HT(3) serotonin receptor-encoding genes, HTR3C, HTR3D, and HTR3E, we investigated whether these novel candidates and the isoform 5-HT(3Ea) are able to form ..
  19. ncbi The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance
    J A Peters
    Division of Pathology and Neuroscience, Neurosciences Institute, Ninewells Hospital and Medical School, The University of Dundee, Dundee DD1 9SY, UK
    Biochem Soc Trans 32:547-52. 2004
    ..subunits, 5-HT3A and 5-HT3B, have been characterized in detail, although additional putative 5-HT3 subunit genes (HTR3C, HTR3D and HTR3E) have recently been reported...
  20. ncbi A cluster of novel serotonin receptor 3-like genes on human chromosome 3
    Alla M Karnovsky
    Department of Bioinformatics, Pharmacia Corporation, Kalamazoo, MI 49007, USA
    Gene 319:137-48. 2003
    ..The 5-HT(3C1) transcript is expressed almost exclusively in small intestine and colon, suggesting a possible role in the serotonin-responsiveness of the gut...