HTR3A

Summary

Gene Symbol: HTR3A
Description: 5-hydroxytryptamine receptor 3A
Alias: 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A, 5-HT3-A, 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic, 5-hydroxytryptamine receptor 3, 5HT3 serotonin receptor, serotonin receptor 3A, serotonin-gated ion channel receptor
Species: human

Top Publications

  1. doi An angiotensin-1 converting enzyme polymorphism is associated with allostatic load mediated by C-reactive protein, interleukin-6 and cortisol
    Alicia K Smith
    Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MSG41, Atlanta, GA 30333, USA
    Psychoneuroendocrinology 34:597-606. 2009
  2. ncbi The 5-HT3B subunit is a major determinant of serotonin-receptor function
    P A Davies
    Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA
    Nature 397:359-63. 1999
  3. ncbi Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients
    B Niesler
    Institute of Human Genetics, University of Heidelberg, Germany
    Pharmacogenetics 11:21-7. 2001
  4. ncbi Association between the 5' UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder
    B Niesler
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Pharmacogenetics 11:471-5. 2001
  5. ncbi Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins
    Gary W Boyd
    Department of Pharmacology and Neuroscience, Ninewells Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom
    Mol Cell Neurosci 21:38-50. 2002
  6. ncbi A cytoplasmic region determines single-channel conductance in 5-HT3 receptors
    Stephen P Kelley
    Neurosciences Institute, Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, The University of Dundee, Dundee DD1 9SY, UK
    Nature 424:321-4. 2003
  7. ncbi A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women
    Jonas Melke
    Departments of Pharmacology, Goteborg University, Goteborg, Sweden
    Arch Gen Psychiatry 60:1017-23. 2003
  8. ncbi Noninvasive imaging of 5-HT3 receptor trafficking in live cells: from biosynthesis to endocytosis
    Erwin Ilegems
    Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology, CH 1015 Lausanne, Switzerland
    J Biol Chem 279:53346-52. 2004
  9. ncbi A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala
    Tetsuya Iidaka
    Department of Psychology, Graduate School of Environmental Studies, Nagoya University, Nagoya, Aichi 464 8601, Japan
    J Neurosci 25:6460-6. 2005
  10. ncbi Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors
    Tim G Hales
    Department of Pharmacology and Physiology, George Washington University, Washington, DC 20037, USA
    J Biol Chem 281:8062-71. 2006

Research Grants

  1. Mark E Pennesi; Fiscal Year: 2015
  2. Kathryn G Lamping; Fiscal Year: 2016
  3. Michael R Koelle; Fiscal Year: 2016
  4. Functional characterization of SSRI resistant genes using C. elegans
    JI Y SZE; Fiscal Year: 2010
  5. John R Cirrito; Fiscal Year: 2016
  6. Post-transcriptional Regulation of Serotonin Receptors
    RONALD EMESON; Fiscal Year: 2006
  7. DRUGS OF ABUSE IN SEROTONIN RECEPTORS KNOCKOUT MICE
    Rene Hen; Fiscal Year: 2003
  8. Serotonin receptors in the inferior colliculus
    Laura Hurley; Fiscal Year: 2006
  9. Joel K Elmquist; Fiscal Year: 2016
  10. James M Cook; Fiscal Year: 2016

Detail Information

Publications382 found, 100 shown here

  1. doi An angiotensin-1 converting enzyme polymorphism is associated with allostatic load mediated by C-reactive protein, interleukin-6 and cortisol
    Alicia K Smith
    Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MSG41, Atlanta, GA 30333, USA
    Psychoneuroendocrinology 34:597-606. 2009
    ..converting enzyme (ACE), corticotropin-releasing hormone receptor 1 (CRHR1), and serotonin receptors (HTR3A and HTR4) were associated with AL (p=0.0007-0...
  2. ncbi The 5-HT3B subunit is a major determinant of serotonin-receptor function
    P A Davies
    Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA
    Nature 397:359-63. 1999
    ..In addition to providing a new target for therapeutic agents, the 5-HT3B subunit will be a valuable resource for defining the molecular mechanisms of ion-channel function...
  3. ncbi Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients
    B Niesler
    Institute of Human Genetics, University of Heidelberg, Germany
    Pharmacogenetics 11:21-7. 2001
    ..In this study, we assessed sequence variations of the HTR3A gene...
  4. ncbi Association between the 5' UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder
    B Niesler
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Pharmacogenetics 11:471-5. 2001
    ..was to identify nucleotide variants in a specific portion of the 5' region of the serotonin receptor gene (HTR3A) containing upstream open reading frames (uORFs) and to investigate their effect on bipolar disease...
  5. ncbi Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins
    Gary W Boyd
    Department of Pharmacology and Neuroscience, Ninewells Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom
    Mol Cell Neurosci 21:38-50. 2002
    ..In support of the existence of homomeric 5-HT3 receptors in vivo, recombinantly expressed 5-HT3A receptors were capable of clustered cell surface expression in cortical neurons...
  6. ncbi A cytoplasmic region determines single-channel conductance in 5-HT3 receptors
    Stephen P Kelley
    Neurosciences Institute, Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, The University of Dundee, Dundee DD1 9SY, UK
    Nature 424:321-4. 2003
    ..Our findings solve the conundrum of the anomalously low conductance of homomeric 5-HT3A receptors and indicate an important function for the HA-stretch in Cys-loop transmitter-gated ion channels...
  7. ncbi A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women
    Jonas Melke
    Departments of Pharmacology, Goteborg University, Goteborg, Sweden
    Arch Gen Psychiatry 60:1017-23. 2003
    ..Serotonin receptor type 3 is a ligand-gated channel encoded by 2 different subunit genes, HTR3A and HTR3B...
  8. ncbi Noninvasive imaging of 5-HT3 receptor trafficking in live cells: from biosynthesis to endocytosis
    Erwin Ilegems
    Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology, CH 1015 Lausanne, Switzerland
    J Biol Chem 279:53346-52. 2004
    ....
  9. ncbi A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala
    Tetsuya Iidaka
    Department of Psychology, Graduate School of Environmental Studies, Nagoya University, Nagoya, Aichi 464 8601, Japan
    J Neurosci 25:6460-6. 2005
    ..for the single nucleotide polymorphism C178T in the regulatory region of the serotonin receptor type 3 gene (HTR3A)...
  10. ncbi Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors
    Tim G Hales
    Department of Pharmacology and Physiology, George Washington University, Washington, DC 20037, USA
    J Biol Chem 281:8062-71. 2006
    ..This locus may be a common determinant of ion conduction throughout the Cys loop receptor family...
  11. ncbi Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Kawaguchi, Saitama, Japan
    Biol Psychiatry 60:192-201. 2006
    Genetic variations in the serotonin receptor 3A (HTR3A) and 3B (HTR3B) genes, positioned in tandem on chromosome 11q23.2, have been shown to be associated with psychiatric disorders in samples of European ancestry...
  12. ncbi The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetine
    T Sugai
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Pharmacogenomics J 6:351-6. 2006
    We investigated the effect of 5-hydroxytryptamine 3A and 3B receptor (HTR3A and HTR3B) gene polymorphisms on nausea induced by paroxetine in Japanese psychiatric patients...
  13. ncbi Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E
    Beate Niesler
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Mol Pharmacol 72:8-17. 2007
    ..These data show for the first time that the novel 5-HT(3) subunits are able to form heteromeric 5-HT(3) receptors, which exhibit quantitatively different functional properties compared with homomeric 5-HT(3A) receptors...
  14. doi First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome
    Johannes Kapeller
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Hum Mol Genet 17:2967-77. 2008
    ..complex conditions, we investigated the untranslated regions (UTRs) of the serotonin receptor type 3 subunit genes HTR3A and HTR3E...
  15. doi Isomerization of the proline in the M2-M3 linker is not required for activation of the human 5-HT3A receptor
    Isabelle M Paulsen
    Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    J Neurochem 110:870-8. 2009
    ..These results demonstrate an important role for P303 in 5-HT(3)A receptor function but indicate that trans-cis isomerization at this proline is unlikely to be a general mechanism underlying the gating process...
  16. doi Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders
    Christian Hammer
    Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld, Germany
    Pharmacogenet Genomics 19:790-9. 2009
    ..food intake depression (anorexic response) have triggered our interest in investigating the putative role of variants in the 5-HT3 receptor genes, HTR3A and HTR3B, in the susceptibility to anorexia nervosa (AN) and bulimia nervosa (BN).
  17. doi Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood
    Justine M Gatt
    The Brain Dynamics Center, Westmead Millennium Institute and Discipline of Psychiatry, University of Sydney at Westmead Hospital, New South Wales, Australia
    Depress Anxiety 27:752-9. 2010
    ..The role of serotonin 3A receptor gene (HTR3A -42C>T polymorphism) and its interaction with early life stress (ELS) was investigated in view of the receptor'..
  18. pmc The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome
    Lisa A Kilpatrick
    Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    Gastroenterology 140:1943-51. 2011
    ..A single nucleotide polymorphism in HTR3A, c...
  19. pmc The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals
    Daniel T Baptista-Hon
    Institute of Academic Anaesthesia, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 288:21558-68. 2013
    ....
  20. ncbi Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3
    Aixin Cheng
    Department of Pharmacology and Neuroscience, Ninewells Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 280:22502-7. 2005
    ....
  21. ncbi Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor
    Tarek Z Deeb
    Department of Pharmacology and Physiology, George Washington University, Washington, DC 20037, USA
    J Biol Chem 282:6172-82. 2007
    ....
  22. ncbi The role of loop F residues in determining differential d-tubocurarine potencies in mouse and human 5-hydroxytryptamine 3A receptors
    Ran Zhang
    Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, 3601 Fourth Street, Lubbock, Texas 79430, USA
    Biochemistry 46:1194-204. 2007
    ..8 +/- 6.38 nM) as that of the human receptor containing all six loop F mouse substitutions. These results demonstrate that two loop F residues make a significant contribution in determining curare potency at the 5-HT3A receptor...
  23. pmc High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor
    Karen Krzywkowski
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 105:722-7. 2008
    ..Thus, the impact of the high-frequency variant 5-HT3B(Y129S) on 5-HT3AB receptor signaling calls for a search for additional phenotypes, and the variant may thus aid in establishing the role of the 5-HT3AB receptor in pathophysiology...
  24. doi Candidate genotypes associated with functional dyspepsia
    N van Lelyveld
    Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neurogastroenterol Motil 20:767-73. 2008
    ..Polymorphisms in genes encoding the serotonin receptor type three A subunit (HTR3A), the serotonin transporter (SERT) and the G-protein beta3 subunit (GNB3) were analysed...
  25. doi Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling
    Karen Krzywkowski
    Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    Pharmacogenet Genomics 18:1027-40. 2008
    ..In this study, we have characterized the effects of four naturally occurring, nonsynonymous variants of the human 5-HT3B subunit on expression and signalling properties of heteromeric 5-HT3AB receptors...
  26. pmc HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors
    Francesca Ducci
    Division of Psychological SGDP Centre, P080 Institue of Psychiatry 16 De Crespigny Park, London SE58AF, United Kingdom
    Alcohol 43:73-84. 2009
    ..We tested whether genetic variation within the HTR3A and HTR3B genes influences vulnerability to AUD with comorbid ASPD (AUD+ASPD) and moderates alpha power...
  27. pmc RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits
    Jutta Walstab
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    J Biol Chem 285:26956-65. 2010
    ..These data implicate a possible role of RIC-3 in determining 5-HT(3) receptor composition in vivo...
  28. ncbi Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species
    A Miyake
    Molecular Medicine Research Laboratory, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    Mol Pharmacol 48:407-16. 1995
    ..Our data revealed that the 5-HT3R molecule has interspecies differences in both tissue distribution and functional profile...
  29. ncbi Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit
    D Belelli
    Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, The University, Dundee, UK
    Mol Pharmacol 48:1054-62. 1995
    ....
  30. ncbi Effect of chronic analgesic exposure on the central serotonin system: a possible mechanism of analgesic abuse headache
    A Srikiatkhachorn
    Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Headache 40:343-50. 2000
    ....
  31. ncbi Up-regulation of 5-HT2 serotonin receptor: a possible mechanism of transformed migraine
    A Srikiatkhachorn
    Neuro- and Behavioural Biology Center, Mahidol University, Salaya, Nakornpathom, Thailand
    Headache 34:8-11. 1994
    ....
  32. ncbi 5-HT2 serotonin receptor on blood platelet of migraine patients
    P Govitrapong
    Neuro and Behavioral Biology Center, Institute of Science and Technology for Development, Mahidol University, Salaya, Nakornpathom, Thailand
    Headache 32:480-4. 1992
    ..This finding implies that serotonin receptors on the platelet may reflect some aspect of the pathogenesis of migraine headache...
  33. ncbi Spontaneous pregnancy-induced hypertension and intrauterine growth restriction in rats
    L C Sharkey
    Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, Grafton, Massachusetts, USA
    Am J Hypertens 14:1058-66. 2001
    ..Thus, SHHF rats may be a valuable tool, because it simultaneously has spontaneous pregnancy-associated hypertension, SGA offsprings, and altered placental gene expression...
  34. ncbi Effects found in a one-year oral toxicity study in Sprague-Dawley rats of a novel 5-HT1A receptor partial agonist for the treatment of anxiety in humans
    G M Zwicker
    Toxicology Department, Marion Merrell Dow Inc, Indianapolis, Indiana 46268, USA
    Toxicol Pathol 24:207-13. 1996
    ..The clinical and pathological changes seen with these 2 regimens were considered exaggerated pharmacological effects of the drug on serotonin receptor-rich organs...
  35. ncbi Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase
    J L Plassat
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, U 184 de l INSERM, département de neurobiologie, Faculte de Medecine, Strasbourg, France
    Mol Pharmacol 44:229-36. 1993
    ..The high affinity of the 5-HTx receptor for neuroleptic agents such as (+)-butaclamol and clozapine suggests also that this receptor might play a role in certain neuropsychiatric disorders...
  36. ncbi Irritable bowel syndrome: new agents targeting serotonin receptor subtypes
    F De Ponti
    Department of Pharmacology, University of Bologna, Italy
    Drugs 61:317-32. 2001
    ....
  37. doi Identification, molecular structure and expression of two cloned serotonin receptors from the pond snail, Helisoma trivolvis
    Sabeen Mapara
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada, T6G 2E9
    J Exp Biol 211:900-10. 2008
    ..In contrast, when isolated neurons were grown in culture, 5-HT(1Hel) and 5-HT(7Hel) immunoreactivity were located primarily in the cell body. This is the first study to reveal a 5-HT(7) receptor in a molluscan species...
  38. ncbi Plasticity of 5-HT serotonin receptor in patients with analgesic-induced transformed migraine
    A Srikiatkhachorn
    Department of Physiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Headache 38:534-9. 1998
    ..These findings indicate that 5-HT2A serotonin receptor system is altered in patients with transformed migraine with analgesic overuse. Such receptor plasticity may be an important step in the pathogenic mechanism of transformed migraine...
  39. ncbi Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype
    Y Shen
    Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:18200-4. 1993
    ..Based on its pharmacology and its localization to limbic and cortical regions of the brain, it is likely that this receptor may play a role in several neuropsychiatric disorders that involve serotonergic systems...
  40. ncbi Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex
    N Limberger
    Pharmakologisches Institut, Universitat, Freiburg, Federal Republic of Germany
    Naunyn Schmiedebergs Arch Pharmacol 343:353-64. 1991
    ..The serotonin axons of rat brain cortex may possess 5-HT1D in addition to 5-HT1B autoreceptors.(ABSTRACT TRUNCATED AT 400 WORDS)..
  41. ncbi Altered serotonin function in suicide. Evidence from platelet and neuroendocrine studies
    G N Pandey
    Department of Psychiatry, University of Illinois at Chicago 60612, USA
    Ann N Y Acad Sci 836:182-200. 1997
    ..The observation that platelet 5-HT2A receptors are increased in suicidal patients independent of diagnosis provides a very useful potential biological marker for identifying suicidal patients...
  42. ncbi Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury
    Baojun Gu
    Department of Surgery, Veterans Affairs Medical Center, Duke University Medical Center, Durham, NC 27710, USA
    J Urol 177:2381-5. 2007
    ....
  43. ncbi Effects of granisetron in the treatment of nausea and vomiting after laparoscopic cholecystectomy: a dose-ranging study
    Yoshitaka Fujii
    Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba, Ibaraki 305 8576, Japan
    Clin Ther 26:1055-60. 2004
    ..Granisetron hydrochloride is a newer SSRA developed for the prevention and treatment of cytotoxic drug-induced emetic symptoms, but its effects in postoperative laparoscopic cholecystectomy have not been studied...
  44. doi Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion
    Wayne E Pratt
    Department of Psychology, Wake Forest University, Winston Salem, NC 27109, USA
    Behav Neurosci 123:1046-57. 2009
    ..These data are the first to suggest that the activation of different serotonin receptor subtypes within the feeding circuitry of the medial nucleus accumbens differentially influence consummatory behavior...
  45. pmc Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus
    Laura M Hurley
    Biology Department, Indiana University, 1001 E Third St, Jordan Hall, Bloomington, IN 47405, USA
    J Neurophysiol 96:2177-88. 2006
    ....
  46. ncbi Neurotransmitter action in osteoblasts: expression of a functional system for serotonin receptor activation and reuptake
    M M Bliziotes
    Portland VA Medical Center, Portland, Oregon 97201, USA
    Bone 29:477-86. 2001
    ..5-HT potentiates the PTH-induced increase in AP-1 activity in UMR cells. These results demonstrate that osteoblastic cells express a functional serotonin system, with mechanisms for responding to and regulating uptake of 5-HT...
  47. ncbi Serotonin receptor blockade increases food intake and body weight after total gastrectomy in rats
    Tilman T Zittel
    University Hospital, Department of General and Transplantation Surgery, University of Tubingen, 72076 Tubingen, Germany
    J Surg Res 106:273-81. 2002
    ..Serotonin inhibits food intake, and postprandial serotonin release is increased after total gastrectomy. Serotonin might contribute to early satiety and loss of body weight after total gastrectomy...
  48. ncbi Characterization of serotonergic receptors in rabbit, porcine and human conjunctivae
    Helen C Turner
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Curr Eye Res 27:205-15. 2003
    ..To characterize the serotonin (5-HT) receptors linked to the modulation of adenylyl cyclase activity in rabbit, porcine and human conjunctivae...
  49. doi Expression changes of serotonin receptor gene subtype 5HT3a in peripheral blood mononuclear cells from schizophrenic patients treated with haloperidol and Olanzapin
    Gholam Reza Shariati
    Department of Medical Genetic, National Institute for Genetic Engineering and Biotechnology NIGEB, Tehran, Iran
    Iran J Allergy Asthma Immunol 8:135-9. 2009
    ..In conclusion, the present study has shown that human PBMC express serotonin receptors 5HT(3a). Moreover, clinical symptom improvement of Olanzapin may be demonstrated by a change in serotonin receptor gene expression...
  50. ncbi Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine
    D G Spencer
    Neurobiology Department, Troponwerke, Koln, Federal Republic of Germany
    Psychopharmacology (Berl) 93:158-66. 1987
    ..These data indicate that the 5-HT1A receptor subtype is strongly involved in the transduction of the interoceptive discriminative stimuli induced by 5-OMe-DMT, with 5-HT2 agonism also playing a possible role...
  51. ncbi A crustacean serotonin receptor: cloning and distribution in the thoracic ganglia of crayfish and freshwater prawn
    Maria A Sosa
    Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00901
    J Comp Neurol 473:526-37. 2004
    ..We also observed receptors that did not possess counterpart 5-HT staining, suggesting that these may also mediate long-term neurohormonal functions of serotonin...
  52. ncbi Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development
    A Bonnin
    Department of Pharmacology, Vanderbilt University, 8114 MRBIII, 465 21st Avenue South, Nashville, TN 37232 8548, USA
    Neuroscience 141:781-94. 2006
    ..Moreover, all members of the 5-HT1 receptor class are strongly and transiently expressed in the embryonic dorsal thalamus, which suggests a potential role for serotonin in early thalamic development...
  53. doi Molecular characterization and analysis of a truncated serotonin receptor gene expressed in neural and reproductive tissues of abalone
    Sasiporn Panasophonkul
    Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand
    Histochem Cell Biol 131:629-42. 2009
    ..Whether this receptor transcript is translated to a functional protein needs to be verified, but if so, it could play a role in reproduction...
  54. ncbi Effects of serotonin-receptor blockade on angioplasty-induced vasospasm in an atherosclerotic rabbit model
    S L Sigal
    Department of Medicine, Yale University School of Medicine West Haven VA Medical Center, New Haven, Conn
    Arterioscler Thromb 11:770-83. 1991
    ..Proximal (2.3 +/- 0.5 before versus 2.5 +/- 0.3 mm after) and distal (1.7 +/- 0.2 before versus 1.7 +/- 0.4 mm after) vasospasm was also prevented by pretreatment with 40 mg sergolexole.(ABSTRACT TRUNCATED AT 400 WORDS)..
  55. ncbi A serotonin receptor antagonist, but not melatonin, modulates hormonal responses to capture stress in two populations of garter snakes (Thamnophis sirtalis parietalis and Thamnophis sirtalis concinnus)
    Deborah I Lutterschmidt
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    Gen Comp Endocrinol 141:259-70. 2005
    ..Our results also suggest that a serotonin-regulated system may play a role in modulating the activity of the hypothalamic-pituitary-gonadal axis during physiological stress responses...
  56. ncbi Short term aerobic exercise training in young males does not alter sensitivity to a central serotonin agonist
    Dan Dwyer
    School of Health Science, Griffith University, PMB 50, GCMC 9726, Australia
    Exp Physiol 87:83-9. 2002
    ....
  57. ncbi Serotonergic modulation of astrocytic activity in the hamster suprachiasmatic nucleus
    J D Glass
    Department of Biological Sciences, Kent State University, OH 44242, USA
    Neuroscience 94:1253-9. 1999
    ..It is interesting to speculate that circadian reorganizations in astrocytic activity could be regulated by the daily rhythm in serotonin release in the suprachiasmatic nucleus...
  58. ncbi Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
    R B Rothman
    Clinical Psychopharmacology Section, Division of Intramural Research, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Circulation 102:2836-41. 2000
    ..We hypothesized that fenfluramine or its metabolite norfenfluramine and other medications known to produce VHD have preferentially high affinities for a particular serotonin receptor subtype capable of stimulating mitogenesis...
  59. ncbi Serotonin stimulates [Ca2+]i elevation in ciliary ectodermal cells of echinoplutei through a serotonin receptor cell network in the blastocoel
    Hideki Katow
    Research Center for Marine Biology, Graduate School of Life Sciences, Tohoku University, Asamushi, Aomori, Aomori 039 3501, Japan
    J Exp Biol 210:403-12. 2007
    ..These results imply that serotonin secreted from the apical ganglion into the blastocoel stimulates the elevation of [Ca(2+)](i) in the larval ectodermal cells through the serotonin receptor cell network...
  60. ncbi Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice
    A J Mayorga
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6140, USA
    J Pharmacol Exp Ther 298:1101-7. 2001
    ..These results suggest that 5-HT(1A) and 5-HT(1B) receptors have different roles in the modulation of the response to antidepressant drugs in the TST...
  61. ncbi Management of platinum-based chemotherapy-induced acute nausea and vomiting: is there a superior serotonin receptor antagonist?
    Mehdi Hamadani
    Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43228, US
    J Oncol Pharm Pract 13:69-75. 2007
    ....
  62. ncbi Plant secondary metabolites as mammalian feeding deterrents: separating the effects of the taste of salicin from its post-ingestive consequences in the common brushtail possum (Trichosurus vulpecula)
    G J Pass
    Department of Zoology and Tropical Ecology, James Cook University, Townsville, Australia
    J Comp Physiol B 170:185-92. 2000
    ..We concluded that pre-ingestive factors were responsible for common brushtail possums limiting their intake of salicin-rich diets rather than any measurable post-ingestive consequence of feeding...
  63. ncbi Effect of a serotonin receptor antagonist on interleukin-6-induced pulmonary hypertension in rats
    M Miyata
    Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima, Japan
    Chest 119:554-61. 2001
    ....
  64. pmc The interaction of trichloroethanol with murine recombinant 5-HT3 receptors
    D L Downie
    Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee
    Br J Pharmacol 114:1641-51. 1995
    ....
  65. ncbi Serotonergic modulation of footshock induced aggression in paired rats
    K P Datla
    Department of Pharmacology, Banaras Hindu University, Varanasi, India
    Indian J Exp Biol 29:631-5. 1991
    ..The data has been discussed in the light of existing knowledge on serotonin receptor subtypes and the presence of modulatory serotonergic heteroreceptors on central dopaminergic neurones...
  66. ncbi Serotonin receptor blockade improves distal perfusion after lower limb ischemia in the fatty Zucker rat
    Philip Janiak
    Cardiovascular Thrombosis Department, Sanofi Synthelabo Research, 1 Avenue Pierre Brossolette, 91385 Cedex, Chilly Mazarin, France
    Cardiovasc Res 56:293-302. 2002
    ..0472, a mixed 5-HT(1B)/5-HT(2A) receptor antagonist, on lower limb ischemia in fatty fa/fa Zucker rats, a strain characterized by obesity, diabetes and hyperlipidemia. Comparison was made with lean control fa/+ Zucker rats...
  67. ncbi Serotonergic synapses modulate generation of spikes from retinal ganglion cells of teleosts
    Soh Hidaka
    Department of Physiology, Fujita Health University, School of Medicine, Toyoake, Aichi 470 1192, Japan
    J Integr Neurosci 8:299-322. 2009
    ....
  68. ncbi Continuous-infusion granisetron compared to ondansetron for the prevention of nausea and vomiting after high-dose chemotherapy
    M Kalaycio
    The Cleveland Clinic Foundation, Ohio 44195, USA
    J Cancer Res Clin Oncol 124:265-9. 1998
    ..A randomized controlled trial was designed to assess the relative efficacy and toxicity of granisetron compared to ondansetron in the setting of autologous stem cell transplantation...
  69. ncbi Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Mol Vis 12:1040-7. 2006
    ..To determine the relative density and tissue localization of mRNAs for serotonin (5-hydroxytryptamine; 5HT) receptor subtypes in human ocular tissues and correlate with their possible functions in the eye...
  70. pmc The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects
    Kurt A Krobert
    MSD Cardiovascular Research Center, University of Oslo, Rikshospitalet University Hospital, Blindern, N 0316 Oslo, Norway
    Br J Pharmacol 135:1563-71. 2002
    ..6. It is concluded that the h5-HT(7) splice variants display similar constitutive activity and inverse agonist properties...
  71. ncbi Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha7 nicotinic acetylcholine receptors
    Anders A Jensen
    Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Eur J Pharmacol 539:27-33. 2006
    ..This study provides an insight into the structure-activity relationships for strychnine and brucine analogues at these ligand-gated ion channels...
  72. ncbi Fluctuation in self-perceived stress and increased risk of flare in patients with lupus nephritis carrying the serotonin receptor 1A -1019 G allele
    Daniel J Birmingham
    Ohio State University, Columbus, OH 43210, USA
    Arthritis Rheum 54:3291-9. 2006
    ..The purpose of this study was to assess the relationship between self-perceived stress (SPS), variability in SPS, and the 2 serotonin-related gene polymorphisms as risk factors for SLE flare...
  73. doi Autoantibodies, polymorphisms in the serotonin pathway, and human leukocyte antigen class II alleles in chronic fatigue syndrome: are they associated with age at onset and specific symptoms?
    Oscar Danilo Ortega-Hernandez
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Ann N Y Acad Sci 1173:589-99. 2009
    ..None of the antibodies determined correlated with any ACFSO or other symptoms. Our results reveal that in CFS, like other autoimmune diseases, different genetic features are related to age at CFS onset and symptoms...
  74. ncbi Randomized, double-blind, placebo-controlled, dosed-finding study of the antiemetic effects and tolerability of ramosetron in adults undergoing middle ear surgery
    Yoshitaka Fujii
    Department of Anesthesiology, Toride Kyodo General Hospital, Toride, Japan
    Clin Ther 25:3100-8. 2003
    ..Although it has been shown that a high dose of ramosetron can cause adverse effects (AEs), such as severe headache, the minimal effective dose of ramosetron is unknown...
  75. ncbi Local anesthetics have different mechanisms and sites of action at recombinant 5-HT3 receptors
    Kazuyoshi Ueta
    Department of Anesthesiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Reg Anesth Pain Med 32:462-70. 2007
    ....
  76. ncbi Ultrasonic vocalizations in rat pups: effects of serotonergic ligands
    B Olivier
    Department of CNS Pharmacology, Solvay Pharmaceuticals, Weesp, The Netherlands
    Neurosci Biobehav Rev 23:215-27. 1998
    ..The 5-HT3 receptor agonist phenylbiguanide and the 5-HT3 receptor antagonist ondansetron had no effect in this paradigm. Clearly, subtypes of the 5-HT receptor affect rat pup USV differentially...
  77. ncbi Effects of tramadol and O-demethyl-tramadol on human 5-HT reuptake carriers and human 5-HT3A receptors: a possible mechanism for tramadol-induced early emesis
    Martin Barann
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Eur J Pharmacol 531:54-8. 2006
    ..The results are compatible with a possible mechanism for tramadol-induced early emesis involving the serotonergic system...
  78. doi The effects of fentanyl-like opioids and hydromorphone on human 5-HT3A receptors
    Maria Wittmann
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatskliniken Bonn, Bonn, Germany
    Anesth Analg 107:107-12. 2008
    ..Therefore, another morphine (phenanthrene-type) derivative, hydromorphone, and fentanyl including its (4-anilinopiperidine-type) derivatives were tested...
  79. doi Persistence with migraine prophylactic treatment and acute migraine medication utilization in the managed care setting
    Avin Z Yaldo
    Ortho McNeil Janssen Scientific Affairs, LLC, Titusville, New Jersey, USA
    Clin Ther 30:2452-60. 2008
    ..The aim of this study was to describe persistence with migraine prophylactic treatment and acute migraine medication utilization in patients prescribed migraine prophylaxis...
  80. ncbi Evaluation of the serotonin receptor blockers ketanserin and methiothepin on the pulmonary hypertensive responses of broilers to intravenously infused serotonin
    M E Chapman
    Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA
    Poult Sci 85:777-86. 2006
    ....
  81. doi Measuring the risk of torsades de pointes: electrocardiographic evaluation of PNU-142093 in conscious cynomolgus non-human primates using restraint and non-restraint procedures
    Alan S Bass
    Drug Safety and Metabolism, Schering Plough Research Institute, Kenilworth, New Jersey 07033 0539, USA
    J Pharmacol Toxicol Methods 60:51-7. 2009
    ..This study was a comparison of the effects of PNU-142093, a selective 5HT1D-serotonin receptor agonist, on QT interval prolongation under restraint and non-restraint conditions in conscious cynomolgus non-human primates...
  82. pmc An in vitro interethnic comparison of monoamine oxidase activities between Japanese and Caucasian livers using rizatriptan, a serotonin receptor 1B/1D agonist, as a model drug
    T Iwasa
    Drug Metabolism, Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, 3 Okubo, Tsukuba, Ibaraki 300 2611, Japan
    Br J Clin Pharmacol 56:537-44. 2003
    ....
  83. pmc Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR)
    L J Strug
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada
    Mol Psychiatry 15:166-76. 2010
    ..Our findings suggest that the serotonin transporter gene may play a role in PD; however, the findings require replication. Future studies should attend to the entire genetic region rather than the promoter...
  84. ncbi Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane
    Richard A Glennon
    Department of Medicinal Chemistry, Box 980540, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Med Chem 47:6034-41. 2004
    ..e., topical), and concentrations necessary to reduce intraocular pressure, compounds such as 6d should demonstrate minimal central effects at potentially useful therapeutic doses and offer useful leads for further development...
  85. ncbi Consensus proposals for the prevention of acute and delayed vomiting and nausea following high-emetic-risk chemotherapy
    Mark G Kris
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Support Care Cancer 13:85-96. 2005
    ..Selective antagonists of the type 3 serotonin receptor (5-HT(3)) in combination with dexamethasone and aprepitant are the standard of care for the prevention of emesis following chemotherapy of high emetic risk...
  86. doi Aprepitant for the prevention of nausea and vomiting associated with chemotherapy and postoperative recovery
    Jennifer Larusso
    Thomas Jefferson University, Department of Pharmacology and Experimental Therapeutics, 132 South 10th Street, 1170 Main, Philadelphia, PA, USA
    Expert Rev Clin Pharmacol 1:27-37. 2008
    ..Aprepitant represents an emerging class of agents and its addition to standard therapy provides an advanced benefit in the prevention and treatment of CINV and PONV. Investigations of aprepitant for other indications are ongoing. ..
  87. doi Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior
    Rhonda P Patrick
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, USA
    FASEB J 29:2207-22. 2015
    ..This model suggests that optimizing vitamin D and marine omega-3 fatty acid intake may help prevent and modulate the severity of brain dysfunction...
  88. ncbi Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs
    F J Monsma
    Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Mol Pharmacol 43:320-7. 1993
    ....
  89. ncbi Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2
    B Weiss
    Institute of Human Genetics, University of Heidelberg, Germany
    Genomics 29:304-5. 1995
  90. ncbi PSA-NCAM immunoreactivity in chandelier cell axon terminals of the human temporal cortex
    Jon I Arellano
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Cereb Cortex 12:617-24. 2002
    ..The results suggest that chandelier terminals in layers II and III of the human entorhinal cortex and temporal neocortex might be particularly susceptible to plastic changes...
  91. ncbi Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes
    E Lerer
    Research Laboratory, Sara Herzog Memorial Hospital, Jerusalem, Israel
    Mol Psychiatry 11:771-81. 2006
    ..29, P=0.01) was a significant risk factor for HND. Further studies should consider the interactive contribution of life events and relevant gene variants to cigarette smoking and other complex behavioral traits...
  92. ncbi Chemosensitivity of unmyelinated axons in isolated human gastric vagus nerve
    Philip M Lang
    Department of Anesthesiology, University of Munich, Germany
    Auton Neurosci 136:100-4. 2007
    ..The presence of receptors indicates that circulating factors may modify vagal afferent neurons also by effects on the axonal membrane...
  93. ncbi Transcriptome alterations in the prefrontal cortex of subjects with schizophrenia who committed suicide
    Krassimira Garbett
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37232, USA
    Neuropsychopharmacol Hung 10:9-14. 2008
    ..Finally, the presented data also strengthens previous reports of neuroimmune transcriptome disturbances in subjects with schizophrenia...
  94. pmc Pharmacological targeting of the serotonergic system for the treatment of obesity
    Alastair S Garfield
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Physiol 587:49-60. 2009
    ..Here we review serotonergic compounds reducing ingestive behaviour and discuss their clinical potential for the treatment of obesity...
  95. ncbi Hypothermic effect of 5-HT1A receptor agonist: comparison of intranasal, intraperitoneal, and subcutaneous routes of administration
    N K Popova
    Laboratory of Behavioral Neurogenomics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia
    Bull Exp Biol Med 146:433-5. 2008
    ..No genotypic differences in the effects of 5-HT1A receptor agonist administered by different routes were detected in four inbred mouse strains...
  96. doi Role of dorsal raphe nucleus 5-HT(1A) and 5-HT(2) receptors in tonic immobility modulation in guinea pigs
    Mateus Dalbem Ferreira
    Department of Physiology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, SP, Brazil
    Brain Res 1285:69-76. 2009
    ..01 microg) of ketanserine. Since the 5-HT(1A) and 5-HT(2) agonists decreased and increased, respectively, the duration of TI, different serotonin receptor subtypes may play distinct roles in the modulation of TI in the guinea pig...
  97. pmc Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain
    Wahida Rahman
    Department of Neuroscience, Pharmacology and Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Mol Pain 5:45. 2009
    ....
  98. doi Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts
    Ermitas Alcalde
    Laboratori de Química Orgànica, Departament de Farmacologia i Quimica Terapeutica, Facultat de Farmacia, Universitat de Barcelona, Avda Joan XXIII s n, 08028 Barcelona, Spain
    Bioorg Med Chem 17:7387-97. 2009
    ..Selected compounds were then tested in a functional cAMP stimulation assay and found to act as 5-HT(6) antagonists, although with moderate potency at the micromolar level...
  99. pmc Psychiatric pharmacogenomic testing in clinical practice
    David A Mrazek
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA
    Dialogues Clin Neurosci 12:69-76. 2010
    ..Given the increasingly clear cost-effectiveness of genotyping, it has recently been predicted that pharmacogenomic testing will routinely be ordered to guide the selection and dosing of psychotropic medications...
  100. doi Effects of yokukansan on anxiety-like behavior in a rat model of cerebrovascular dementia
    Ai Nogami
    Department of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    J Nat Med 65:275-81. 2011
    ..This study revealed that yokukansan shows anxiolytic effects not only in normal animals but also in cerebrovascular model rats...
  101. doi 5-HT(3) receptors: potential of individual isoforms for personalised therapy
    Beate Niesler
    Institute of Human Genetics, Department of Human Molecular Genetics, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Curr Opin Pharmacol 11:81-6. 2011
    ..In humans, five subunits exist (5-HT3A-E) which are encoded by the genes HTR3A-E and are expressed in various isoforms...

Research Grants64

  1. Mark E Pennesi; Fiscal Year: 2015
    ..While some of these diseases are rare, they can lead to complete blindness, thus making their impact on public health significant. ..
  2. Kathryn G Lamping; Fiscal Year: 2016
    ..We will compare the effects of inhibition (siRNA) or overexpression of caveolin-1 using viral transfection on vascular responses to specific serotonin receptor agonists or direct activation of rhoA in non-diabetic and diabetic mice. ..
  3. Michael R Koelle; Fiscal Year: 2016
    ..Understanding in detail how neurotransmitters act should make it possible to precisely define the defects that cause mental disorders and to thus develop effective treatments for them.) ..
  4. Functional characterization of SSRI resistant genes using C. elegans
    JI Y SZE; Fiscal Year: 2010
    ..These in turn will provide clues about the genetic basis underlying the pathogenesis and offer new windows for the discovery of novel therapeutics. ..
  5. John R Cirrito; Fiscal Year: 2016
    ....
  6. Post-transcriptional Regulation of Serotonin Receptors
    RONALD EMESON; Fiscal Year: 2006
    ..It is anticipated that these studies will provide new insights concerning the regulation of cellular processes involved in the transduction of serotonergic signals and the role(s) of multiple serotonin receptors in the nervous system. ..
  7. DRUGS OF ABUSE IN SEROTONIN RECEPTORS KNOCKOUT MICE
    Rene Hen; Fiscal Year: 2003
    ..abstract_text> ..
  8. Serotonin receptors in the inferior colliculus
    Laura Hurley; Fiscal Year: 2006
    ..By proposing such basic research that may eventually contribute to quality of life, this application furthers the first goal of the Healthy People 2010 initiative. [unreadable] [unreadable]..
  9. Joel K Elmquist; Fiscal Year: 2016
    ..Results from these studies will advance our understanding of the serotoninergic circuits necessary to permit the design of effective treatment strategies for obesity and diabetes. ..
  10. James M Cook; Fiscal Year: 2016
    ..The proposed work is significant because it represents the first step in a continuum of research to develop the first therapies for impaired cognitive function and negative symptoms of schizophrenia patients. ..
  11. CHAD EDWARD BEYER; Fiscal Year: 2014
    ....
  12. CYNTHIA M CZAJKOWSKI; Fiscal Year: 2016
    ..of the pentameric LGIC superfamily include nicotinic acetylcholine receptors (nAChR), serotonin-type-3 receptors (5HT3R), gamma-amino butyric acid type A receptors (GABAAR) and glycine receptors...
  13. Structure of the GABA-A Receptor Binding Sites
    CYNTHIA M CZAJKOWSKI; Fiscal Year: 2012
    ..of the pentameric LGIC superfamily include nicotinic acetylcholine receptors (nAChR), serotonin-type-3 receptors (5HT3R), gamma-amino butyric acid type A receptors (GABAAR) and glycine receptors...
  14. SEROTONIN RECEPTOR IMAGING DURING ANTIDEPRESSANT THERAPY
    Mark Mintun; Fiscal Year: 1999
    ..A clearer understanding of the changes in the neurotransmitter systems during pharmacological and other treatments of depression should provide an improved rationale for the development of efficacious interventions in the future. ..
  15. PEPTIDE PROBES OF THE 5HT1A RECEPTOR/G PROTEIN INTERFAC
    Keith Parker; Fiscal Year: 1999
    ..Information from our studies will add essential knowledge to modeling the receptor superfamily. Development of novel therapeutic drugs may follow. ..
  16. ASTROGLIAL SEROTONIN RECEPTORS
    Patricia Whitaker Azmitia; Fiscal Year: 1990
    ..We will also begin studies of co-cultures of astrocytes and serotonin neurons, to further elucidate this role...
  17. IMMUNOLOGICAL ANALYSIS-BRAIN SEROTONIN BINDING PROTEINS
    RICHARD TODD; Fiscal Year: 1990
    ..These studies will test genetic and immunopathological hypotheses about the etiology of autism and may provide the tools for the development of in vitro and in vivo model systems of autism...
  18. Long-Term Safety and Genetic Risk Factors of Risperdone Treatment in Youth
    Chadi A Calarge; Fiscal Year: 2010
    ....
  19. Novel transgenic tools for analysis of 5HT2C receptor expression and function
    Ronald B Emeson; Fiscal Year: 2013
    ..g. disease-associated SNPs, reporter constructs, toxins, null/conditional alleles) into the 5HT2C receptor gene, thus expanding research into human psychiatric disorders related to altered 5HT2C function. ..
  20. Combining mammalian and Drosophila systems to study neuropsychiatric disorders
    Charles D Nichols; Fiscal Year: 2012
    ..Significantly, our results may lead to novel avenues for therapeutics to treat such devastating diseases as schizophrenia and psychosis. ..
  21. Physiological Implications of Serotonin Receptor Regulation
    Laura M Bohn; Fiscal Year: 2013
    ..Such strategies in drug design may prove to be clinically useful for treating neuropsychiatric disorders including those associated with drugs of abuse. ..
  22. MICHAEL VINCENT LEVINE; Fiscal Year: 2015
    ..I will produce new experimentally testable hypotheses and work with experimental collaborators in the design of new types of experiments aimed at expanding the understanding the mechanisms of such drugs and medications. ..
  23. Selective Imaging Agents for the 5HT2c Receptor
    Jacob M Hooker; Fiscal Year: 2013
    ..The outcome of this research will be a new technology for imaging 5HT2c receptors in vivo that can be used in both preclinical and human research to establish relationships between 5HT2c physiology and brain diseases. ..
  24. Control of Cardiogenesis by microRNA Editing
    Kazuko Nishikura; Fiscal Year: 2010
    ....
  25. Serotonergic Immunomodulation in Neuroinflammatory Disease
    CATHERINE ELIZABETH HAGAN; Fiscal Year: 2012
    ..S., a d Non-citizen with temporary visa non-citizen national notarized statement must be provided by the time of award.) (Applicable for only the K99 program) PHS 398 (Rev. 04/06) Page 4 CDA Substitute Form Page 3 ..
  26. Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig Model
    William P Melega; Fiscal Year: 2010
    ..Electrical stimulation of the specific brain regions involved in feeding behavior will result in modulation of food intake and body weight. We will show that this intervention method is safe and effective for long term weight control. ..
  27. Role of Serotonin in Smypathetic Function
    Karie E Scrogin; Fiscal Year: 2012
    ..Our studies will attempt to validate a new, promising therapy that may help patients recover from circulatory shock without further injuring tissue during the resuscitation process. ..
  28. Mark A Geyer; Fiscal Year: 2015
    ..Such information is critical to understand the consequences of the use of these compounds and to provide models of psychosis that could help identify novel therapeutic targets for neuropsychiatric disorders. ..
  29. Genetic Epidemiology of Opioid Dependence in Bulgaria
    Alexandre A Todorov; Fiscal Year: 2010
    ..The large sample size for this study would make such genes amenable to analysis. ..
  30. KAREN ELAINE RITTER; Fiscal Year: 2016
    ..Mutant mice expressing a hypersensitive form of the 5-HT3A receptor gene, Htr3a vs/vs, display a hypertrophic bladder phenotype in conjunction with urinary incontinence...
  31. AMYLOID PLAQUE AND TANGLE IMAGING IN AGING AND DEMENTIA
    GARY WILLIAM SMALL; Fiscal Year: 2010
    ....
  32. A Unique Natural Model for Studying the Mechanisms Underlying Social Behavior
    Donna L Maney; Fiscal Year: 2013
    ..Here, we will study these influences in an animal model with a natural polymorphism that provides a unique opportunity to characterize the processes underlying aggression and parenting. ..
  33. John F Neumaier; Fiscal Year: 2014
    ..These experiments will create a platform for determining whether targeting cell signaling mechanisms in the cilia will offer new opportunities for developing therapeutics for addiction and other compulsive disorders. ..
  34. HYPOXIC EFFECTS ON MAMMALIAN RESPIRATORY NEURAL NETWORK
    JAN M RAMIREZ; Fiscal Year: 2010
    ..Our studies are directly relevant for SIDS as increasing evidence indicates that SIDS victims have diminished gasping and fail to arouse. Moreover SIDS victims have disturbed noradrenergic and serotonergic metabolism. ..
  35. Keith W Miller; Fiscal Year: 2016
    ..to inhibit, and in some cases enhance, the excitatory neuronal nicotinic acetylcholine (nAcChoR) and serotonin (5HT3R) receptors...
  36. A Novel Approach of beta Cell Replacement to Reverse Type I Diabetes in NOD Mice
    Roland M Tisch; Fiscal Year: 2013
    ..Experiments will also be included to assess the effects of ectopic prolactin expression on inflammation in the pancreas. ..
  37. Identification of substances that change alternative pre-mRNA splicing of the ser
    Stefan Stamm; Fiscal Year: 2012
    ..Identifying a compound that combats obesity would have a major therapeutic impact and the possible identification of the first mammalian riboswitch will have a strong scientific impact. ..
  38. Treating Suicidal Behavior and Self-Mutilation in BPD
    Barbara Stanley; Fiscal Year: 2012
    ....
  39. Alexei Morozov; Fiscal Year: 2014
    ..abstract_text> ..
  40. Cerebrovascular Afferent Mechanisms of Migraine
    ANDREA MARIE HARRIOTT; Fiscal Year: 2010
    ..The results from these experiments should help provide unique targets for the treatment of migraine pain and increase the understanding of cerebrovascular afferent mechanisms in initiating migraine pain. ..
  41. Jeffrey L Benovic; Fiscal Year: 2016
    ..These studies will provide important insight that is highly relevant to not only understanding GRKs in the worm but also to understanding how GRKs function in humans. ..
  42. Mechanisms of Triptan Action in Migraine and Pain
    Andrew Ahn; Fiscal Year: 2009
    ..He has the wholehearted encouragement of his institution in applying for a clinician-investigator position with a focus on migraine research in the coming years. ..
  43. Impact of energy status on the serotonergic regulation of energy balance
    Laurence H Tecott; Fiscal Year: 2013
    ..In Aim 3 will generate and validate conditional mutant mice to selectively eliminate 5-HT1B and 5-HT2C receptor expression in neurons expressing the neuropeptides NPY/AGRP and POMC/CART, respectively. ..
  44. Bernardo Rudy; Fiscal Year: 2016
    ..abstract_text> ..
  45. Role of serotonin in auditory cortex regulation following early-onset sensorineur
    GREGORY BASURA; Fiscal Year: 2009
    ....
  46. MODELS TO ANALYZE SEROTONIN RECEPTOR FUNCTIONS
    Laurence Tecott; Fiscal Year: 1999
    ..Observations of behavioral deficits in these animals could spur a search for genetic and developmental abnormalities of serotonin receptor function in mental illnesses. ..
  47. Qian Quan Sun; Fiscal Year: 2014
    ..Therefore, unveiling the cortical interneuronal circuit organization will also help o build the groundwork for future dissection of specific interneuronal types, synapses and circuits altered by mental diseases. ..
  48. Ligand Binding Domains in the 5-HT3 Receptor
    Tina Machu; Fiscal Year: 2006
    ..abstract_text> ..
  49. SEROTONIN RECEPTOR LIGANDS FOR SPECT IMAGING
    HANK KUNG; Fiscal Year: 2001
    ..The novel imaging agents may lead to simple and useful routine diagnostic procedures for various mental health diseases involving SERT in the brain. ..
  50. SEROTONIN RECEPTOR LIGANDS FOR SPECT IMAGING
    HANK KUNG; Fiscal Year: 2004
    ..The novel imaging agents may lead to simple and useful routine diagnostic procedures for various mental health diseases involving SERT in the brain. ..
  51. SEROTONIN RECEPTOR REGULATION AND BEHAVIOR
    Irwin Lucki; Fiscal Year: 2003
    ..The results of the proposed work should have important implications for our understanding of the mechanisms involved in the behavioral effects of SSRIs in the clinical treatment of depression. ..
  52. Identification of 5-HT1A Receptor Phosphorylation Sites
    ANDREW GELASCO; Fiscal Year: 2004
    ....
  53. FUNCTIONAL ROLE OF IDOLEAMINES IN RETINA
    WILLIAM BRUNKEN; Fiscal Year: 1993
    ..This proposal seeks to couple a cellular understanding of transmitter action with its network role. ..
  54. Ethanol Modulation of Zinc-Activated Channels
    PAUL ANDREW DAVIES; Fiscal Year: 2010
    ..This project looks at a new alcohol sensitive protein found in the areas of the hippocampus that is most at risk from alcohol damage and examines the actions of alcohol on this protein. ..
  55. Charles B Nemeroff; Fiscal Year: 2016
    ..risk factors include polymorphisms of the ADCYAP1R1, FKBP5, DAT, BDNF, COMT, CRFR1, 5HTTLPR, RGS2, GABA2 and 5HT3R genes, novel genetic and epigenetic risk factors and most importantly, the primary downstream effects of these ..
  56. Kerry J Ressler; Fiscal Year: 2016
    ..risk factors include polymorphisms of the ADCYAP1R1, FKBP5, DAT, BDNF, COMT, CRFR1, 5HTTLPR, RGS2, GABA2 and 5HT3R genes, novel genetic and epigenetic risk factors and most importantly, the primary downstream effects of these ..
  57. MODULATORY ROLE OF GABA AND 5HT RECEPTORS IN MIGRAINE
    F Cutrer; Fiscal Year: 1999
    ..With these proposed experiments we seek to better understand the receptor pharmacology of vascular headaches to thereby establish a more rational basis for new drug discovery in migraine and cluster headache. ..
  58. Microcantilever Biosensors Based on Ligand Gated Ion Channel Receptors
    MARVIN KENNETH SCHULTE; Fiscal Year: 2010
    ..Aim 2 will utilize the AChBP and other receptor proteins to improve sensor response through improved conjugation chemistries in combination with improved microcantilever array technology developed in Dr. Ji's laboratory ..
  59. BIOSYNTHESIS OF OLEAMIDE AND OTHER FATTY ACID AMIDES
    DAVID MERKLER; Fiscal Year: 1999
    ..Accomplishing this goal will establish the role of a-AE and oleoylglycine in the biosynthesis oleamide in the mammalian cells of neural origin. ..
  60. ALPHA1 GLYCINE RECEPTOR STRUCTURE AND FUNCTION
    Michael Cascio; Fiscal Year: 1999
    ..Site-directed mutagenesis coupled with covalent modification will be used to probe channel topology. In addition, the construction of chimeric channel proteins will allow structure- function maps to be constructed for this ion channel. ..
  61. Symptoms, Serotonin and Amino Acids in Anorexia Nervosa
    David Jimerson; Fiscal Year: 2007
    ..This exploratory study will assess whether abnormal regulation of the naturally occurring neurochemical serotonin may contribute to this important public health problem. [unreadable] [unreadable]..
  62. Structural Studies of the Glycine Receptor
    Michael Cascio; Fiscal Year: 2003
    ..Overall these investigations aim to provide insight into the general conserved structure of nicotinicoid channels. ..
  63. STRUCTURE OF AN EDITING ENZYME DSRNA ADENOSINE DEAMINASE
    Alexander Rich; Fiscal Year: 2002
    ..Knowledge of the structure of the enzyme associated with its complex substrates should provide significant insight into the manner in which this enzyme selectively alters the genetic message. ..
  64. EDITING OF PRE MRNA IN NEUROLOGICAL CELL LINES
    Katheleen Gardiner; Fiscal Year: 2002
    ..Definition of new substrates for RNA editing will define new sources of protein diversity and regulation of gene expression, and will identify new candidates for neurological disease and developmental anomalies. ..