Genomes and Genes
Gene Symbol: HSD17B10
Description: hydroxysteroid 17-beta dehydrogenase 10
Alias: 17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, 3-hydroxyacyl-CoA dehydrogenase type-2, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, AB-binding alcohol dehydrogenase, amyloid-beta peptide binding alcohol dehydrogenase, endoplasmic reticulum-associated amyloid beta-peptide-binding protein, mitochondrial RNase P subunit 2, mitochondrial ribonuclease P protein 2, short chain L-3-hydroxyacyl-CoA dehydrogenase type 2, short chain type dehydrogenase/reductase XH98G2
Publications191 found, 100 shown here
- Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequenceP J Vredendaal
Department for Metabolic Diseases, Wilhelmina Childrens Hospital, Utrecht, The Netherlands
Biochem Biophys Res Commun 223:718-23. 1996The cDNA encompassing the complete coding sequence of human liver short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) was isolated and characterized...
- Genetic polymorphisms of 17 β-hydroxysteroid dehydrogenase 3 and the risk of hypospadiasFumihiro Sata
Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Sex Med 7:2729-38. 2010..In this regard, enzymes 17 β-hydroxysteroid dehydrogenase type 3 (17 β HSD3, encoded by HSD17B3) and steroid 5 α-reductase type 2 (encoded by SRD5A2) play crucial roles...
- 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: an X-linked inborn error of isoleucine metabolism that may mimic a mitochondrial diseaseCelia Perez-Cerda
Institut de Bioquímica, Corporaciò Sanitària Cláinic, Edifici Helios III, 08028 Barcelona, Spain
Pediatr Res 58:488-91. 2005We describe three patients, from two Spanish families, with 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency, a recently described X-linked neurodegenerative inborn error of isoleucine metabolism...
- 3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and diseaseSong Yu Yang
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
FEBS J 272:4874-83. 2005..HAD has a preference for medium chain substrates, whereas short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) acts on a wide spectrum of substrates, including steroids, cholic acids, and fatty acids, with a preference for ..
- An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's diseaseS D Yan
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Nature 389:689-95. 1997..It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in ..
- A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's diseaseX Y He
Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
J Biol Chem 273:10741-6. 1998..of this human brain enzyme is identical to that of an endoplasmic reticulum amyloid beta-peptide-binding protein (ERAB), which mediates neurotoxicity in Alzheimer's disease (Yan, S. D., Fu, J., Soto, C., Chen, X., Zhu, H...
- Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicityS D Yan
Departments of Pathology, Physiology and Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
J Biol Chem 274:2145-56. 1999Endoplasmic reticulum-associated amyloid beta-peptide (Abeta)-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II (HADH II) is expressed at high levels in Alzheimer's disease (AD)-affected brain, binds Abeta, and contributes ..
- Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenaseX Y He
Departments of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
J Biol Chem 274:15014-9. 1999Human brain short chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) was found to catalyze the oxidation of 17beta-estradiol and dihydroandrosterone as well as alcohols...
- Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's diseaseU C Oppermann
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
FEBS Lett 451:238-42. 1999The intracellular amyloid beta-peptide (A beta) binding protein, ERAB, a member of the short-chain dehydrogenase/reductase (SDR) family, is known to mediate apoptosis in different cell lines and to be a class II hydroxyacyl-CoA ..
- Characterization and localization of human type10 17beta-hydroxysteroid dehydrogenaseX Y He
Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, New York 10314, USA
Eur J Biochem 268:4899-907. 2001..studies demonstrate that this protein, which has been referred to as ER-associated amyloid beta-binding protein (ERAB), is not detectable in the ER of normal tissues...
- Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease modelXue Ying He
Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
Brain Res Mol Brain Res 99:46-53. 2002..reticulum as suggested by its trivial name 'endoplasmic reticulum-associated amyloid-beta biding protein (ERAB)'...
- 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 geneRob Ofman
Department of Clinical Chemistry, Academic Medical Center, Emma Children s Hospital, University of Amsterdam, The Netherlands
Am J Hum Genet 72:1300-7. 2003..This led to the identification of the X-chromosomal gene involved, which previously had been denoted "HADH2." Sequence analysis of the HADH2 gene from patients with MHBD deficiency revealed the presence of two missense ..
- Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HNaeem Shafqat
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Biochem J 376:49-60. 2003....
- Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenaseXue Ying He
Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
J Steroid Biochem Mol Biol 87:191-8. 2003..The experimental results lead to the conclusion that mitochondrial 17beta-HSD10 plays a significant part in a non-classical androgen synthesis pathway along with microsomal retinol dehydrogenases...
- ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's diseaseJoyce W Lustbader
Center for Reproductive Sciences and Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
Science 304:448-52. 2004..Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity...
- Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeuticsCharles R Kissinger
Pfizer La Jolla, 10777 Science Center Dr, San Diego, CA 92121, USA
J Mol Biol 342:943-52. 2004..dehydrogenase type 10 (HSD10), also known as amyloid beta-peptide-binding alcohol dehydrogenase (ABAD), has been implicated in the development of Alzheimer's disease...
- ABAD enhances Abeta-induced cell stress via mitochondrial dysfunctionKazuhiro Takuma
Departments of Surgery, Pathology, and Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
FASEB J 19:597-8. 2005Amyloid-beta peptide (Abeta) binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, is a cofactor facilitating Abeta-induced cell stress...
- Intracellular oxidation of allopregnanolone by human brain type 10 17beta-hydroxysteroid dehydrogenaseXue Ying He
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
Brain Res 1040:29-35. 2005..The elevated level of 17beta-HSD10 in activated astrocytes is a new feature found in brains of people with AD, and it may have important impact on AD pathogenesis...
- HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroidsSong Yu Yang
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
Mol Genet Metab 92:36-42. 2007The HSD17B10 gene maps on chromosome Xp11.2, a region highly associated with X-linked mental retardation...
- RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzymeJohann Holzmann
Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria
Cell 135:462-74. 2008..Apparently, animal mitochondria lost the seemingly ubiquitous RNA world remnant after reinventing RNase P from preexisting components...
- Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolismSong Yu Yang
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
Proc Natl Acad Sci U S A 106:14820-4. 2009Mutations in the HSD17B10 gene were identified in two previously described mentally retarded males. A point mutation c.776G>C was found from a survivor (SV), whereas a potent mutation, c...
- Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosisZdena Kristofikova
Alzheimer Disease Center, Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic
Mol Biosyst 5:1174-9. 2009..In patients with multiple sclerosis, our results are the first to demonstrate significant changes in enzyme expression and to suggest possible alterations in amyloid beta peptides...
- A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survivalKatharina Rauschenberger
Institute of Human Genetics, Heidelberg University, Heidelberg, Germany
EMBO Mol Med 2:51-62. 2010..The disease-causing gene is HSD17B10 and encodes 17beta-hydroxysteroid dehydrogenase type 10 (HSD10), a protein also implicated in the pathogenesis of ..
- Type 10 17β-hydroxysteroid dehydrogenase expression is regulated by C/EBPβ in HepG2 cellsMirja Rotinen
Department of Health Sciences, Universidad Publica de Navarra, Avda Barañain, 31008 Pamplona, Spain
J Steroid Biochem Mol Biol 122:164-71. 2010..C/EBPα or C/EBPβ in HepG2 cells showed that HSD17B11 expression was induced by both transcription factors while HSD17B10 expression was only induced by C/EBPβ...
- X-inactivation of HSD17B10 revealed by cDNA analysis in two female patients with 17β-hydroxysteroid dehydrogenase 10 deficiencyJudit Garcia-Villoria
Sección de Errores Congénitos del Metabolismo IBC, Servicio de Bioquímica y Genética Molecular, Hospital Clinic, IDIBAPS, Barcelona, Spain
Eur J Hum Genet 18:1353-5. 2010..The gene encoding HSD10, HSD17B10, has been reported as one of the few genes that escapes X-inactivation...
- Behavioral stress causes mitochondrial dysfunction via ABAD up-regulation and aggravates plaque pathology in the brain of a mouse model of Alzheimer diseaseJi Seon Seo
Department of Brain and Cognitive Sciences, Ewha Women s University, Seoul 120 750, Republic of Korea
Free Radic Biol Med 50:1526-35. 2011..corticosterone) and Aβ in SH-SY5Y cells increased the expression of 17β-hydroxysteroid dehydrogenase (ABAD), mitochondrial dysfunction, and levels of ROS, whereas blockade of ABAD expression by siRNA-ABAD in SH-SY5Y cells ..
- A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesisElisa Vilardo
Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria
Nucleic Acids Res 40:11583-93. 2012..Human mitochondrial RNase P, thus, constitutes a multifunctional complex, whose subunits moonlight in cascade: a fatty and amino acid degradation enzyme in tRNA methylation and the methyltransferase, in turn, in tRNA 5' end processing...
- A 5-methylcytosine hotspot responsible for the prevalent HSD17B10 mutationSong Yu Yang
Department of Developmental Biochemistry, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
Gene 515:380-4. 2013..hydroxysteroid (17β) dehydrogenase X (HSD10) deficiency are due to a missense C>T mutation in exon 4 of the HSD17B10 gene. The resulting HSD10 (p...
- Chromosomal basis of X chromosome inactivation: identification of a multigene domain in Xp11.21-p11.22 that escapes X inactivationA P Miller
Department of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 95:8709-14. 1998..Genes located both distal and proximal to this cluster are subject to inactivation, thereby defining a unique multigene domain on the proximal short arm that is transcriptionally active on the inactive X chromosome...
- Comparative evolutionary genomics of the HADH2 gene encoding Abeta-binding alcohol dehydrogenase/17beta-hydroxysteroid dehydrogenase type 10 (ABAD/HSD10)Alexandra T Marques
REQUIMTE, Departamento de Quimica, Faculdade de Ciencias, Universidade do Porto, Rua do Campo Alegre, 687, 4169 007 Porto, Portugal
BMC Genomics 7:202. 2006..Here we use comparative genomic analyses to study the evolution of the HADH2 gene encoding ABAD/HSD10 across several eukaryotic species.
- The reduced expression of the HADH2 protein causes X-linked mental retardation, choreoathetosis, and abnormal behaviorClaus Lenski
Department of Obstetrics and Gynecology, Technical University, Munich, Germany
Am J Hum Genet 80:372-7. 2007..with a unique clinical phenotype characterized by mild mental retardation, choreoathetosis, and abnormal behavior (MRXS10). Linkage analysis in this family revealed a candidate region of 13...
- Estrogen receptor alpha interacts with 17beta-hydroxysteroid dehydrogenase type 10 in mitochondriaVirginija Jazbutyte
Laboratory of Molecular Cardiology, Department of Medicine, University Clinics Wuerzburg, Josef Schneider Strasse 2, D20, 97080 Wuerzburg, Germany
Biochem Biophys Res Commun 384:450-4. 2009..GST pull-down experiments confirmed the interaction of ERalpha and 17beta-HSD10. These findings suggest that the ERalpha estrogen receptor might be involved in regulating intracellular estrogen levels by modulating 17beta-HSD10 activity...
- Cloning and expression of cDNA for a newly identified isozyme of bovine liver 3-hydroxyacyl-CoA dehydrogenase and its import into mitochondriaS Furuta
Department of Biochemistry, Shinshu University School of Medicine, Nagano, Japan
Biochim Biophys Acta 1350:317-24. 1997....
- Framing access to medicines in developing countries: an analysis of media coverage of Canada's Access to Medicines RegimeLaura C Esmail
Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada
BMC Int Health Hum Rights 10:1. 2010..Over the course of eight months, the legislation, now known as Canada's Access to Medicines Regime (CAMR), went through a controversial policy development process and the newspaper media was one of the major venues in ..
- Dominantly inherited hyperinsulinaemic hypoglycaemiaP de Lonlay
INSERM U393 and Department of Pediatrics, Hopital Necker Enfants Malades, Paris, France
J Inherit Metab Dis 28:267-76. 2005..dominantly inherited HI; (ii) metabolic disorders implicating the short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) enzyme inrecessively inherited HI, the glucokinase gene (GK), the glutamate dehydrogenase gene (GLUD1) when ..
- The benefits and costs of reducing emissions from the electricity sectorKaren Palmer
Resources for the Future, 1616 P Street, NW, Washington, DC 20036, USA
J Environ Manage 83:115-30. 2007..Rule (CAIR) as characterized in the supplemental rule proposed in June 2004, and the Clean Air Mercury Rule (CAMR) as proposed in February 2004...
- Effect of sowing dates on yield and yield components of spring safflower (Carthamus tinctorius L.) in Isfahan regionS Nikabadi
Department of Agronomy, Faculty of Agriculture, Islamic Azad University, Branch of Khorasgan, Isfahan, Iran
Pak J Biol Sci 11:1953-6. 2008..of two safflower varieties, an experiment was conducted at Agriculture Research Station of Isfahan Kabotar Abad in 2004...
- Regional localisation of two non-specific X-linked mental retardation genes (MRX30 and MRX31)A J Donnelly
Department of Cytogenetics and Molecular Genetics, Women s and Children s Hospital, Adelaide, Australia
Am J Med Genet 64:113-20. 1996..3) and DXS424 (Xq24). A significant multipoint lod score of 2.78 was detected between the loci DXS1120 and DXS456. MRX31 maps to a 12 cM region that spans the centromere from DXS1126 (Xp11.23) to DXS1124 (Xq13.3)...
- Indoor radon levels and lung cancer risk estimates in seven cities of the Bahawalpur Division, Pakistan- Matiullah
Pakistan Institute of Engineering and Applied Sciences, P O Nilore, Islamabad, Pakistan
Radiat Prot Dosimetry 107:269-76. 2003..These included Fort Abbas, Minchin Abad, Hasilpur, Bahawalpur, Liaqatpur, Rahimyar Khan and Sadiq Abad...
- Variants of smooth Salmonella enterica serovar Enteritidis that grow to higher cell density than the wild type are more virulentJ Guard-Petter
Agricultural Research Service, United States Department of Agriculture, Athens, Georgia 30605, USA
Appl Environ Microbiol 64:2166-72. 1998..Whereas SE-HCD1 killed 70% of 6-day-old chicks challenged subcutaneously, the same dose of SE-HCD2 did not kill any chicks...
- Transcription of the cam operon and camR genes in Pseudomonas putida PpG1M Fujita
Department of Biotechnology, Faculty of Engineering, Fukuyama University, Hiroshima, Japan
J Bacteriol 175:6953-8. 1993..operon (camDCAB) encoding enzymes involved in the degradation pathway of D-camphor is negatively regulated by the CamR protein, and camR is autorepressed...
- Reye-like syndrome resulting from novel missense mutations in mitochondrial medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenaseMichael J Bennett
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
Mol Genet Metab 89:74-9. 2006Medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase (M/SCHAD) deficiency is a recessively inherited disorder of fatty acid oxidation. Currently, only four patients from three families have been reported in the literature...
- Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistanceLynn G Dover
School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
J Mol Biol 340:1095-105. 2004..Activation of the pro-drug ethionamide is regulated by the Baeyer-Villiger monooxygenase EthA and the TetR/CamR family repressor EthR, whose open reading frames are separated by 75 bp on the Mycobacterium tuberculosis genome...
- Soil contamination with Toxocara spp. eggs in the public parks from three areas of Khorram Abad, IranM Zibaei
Department of Parasitology, School of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran
Nepal Med Coll J 12:63-5. 2010..The present investigation clearly shows that public parks have been contaminated with Toxocara eggs in Khorram Abad, suggesting that care should be taken when using public parks.
- Deletion of new covalently linked cell wall glycoproteins alters the electrophoretic mobility of phosphorylated wall components of Saccharomyces cerevisiaeV Mrsa
Lehrstuhl für Zellbiologie und Pflanzenphysiologie, Universitat Regensburg, 93040 Regensburg, Germany
J Bacteriol 181:3076-86. 1999..Moukadiri, J. Armero, A. Abad, R. Sentandreu, and J. Zueco, J. Bacteriol. 179:2154-2162, 1997)...
- Isfahan Healthy Heart Programme: a comprehensive integrated community-based programme for cardiovascular disease prevention and control. Design, methods and initial experienceNizal Sarraf-Zadegan
Isfahan Cardiovascular Center, Isfahan University of Medical Sciences, Isfahan, Iran
Acta Cardiol 58:309-20. 2003..A primary survey was done to collect baseline data from interventional (Isfahan and Najaf-Abad) and reference (Arak) communities...
- Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductaseA Goodwin
Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Mol Microbiol 28:383-93. 1998..pylori rendered it MtzS; and (iii) replacement of rdxA in MtzS H. pylori with an rdxA::camR null insertion allele resulted in a MtzR phenotype. The 630 bp rdxA genes of five pairs of H...
- Evidence that 2-methylacetoacetate induces oxidative stress in rat brainGuilhian Leipnitz
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal de Rio Grande do Sul, Rua Ramiro Barcelos, Anexo, Porto Alegre, RS, Brazil
Metab Brain Dis 25:261-7. 2010..in mitochondrial 2-methylacetoacetyl-CoA thiolase (KT) and 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiencies, on important parameters of oxidative stress in cerebral cortex from young rats...
- Fluorodeoxyglucose positron emission tomography for the diagnosis of sarcoidosis in patients with unexplained chronic uveitisPascal Seve
Department of Internal Medicine, Hotel Dieu, Hospices Civils de Lyon, Lyon, France
Ocul Immunol Inflamm 17:179-84. 2009..To assess the value of fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in patients with unexplained chronic uveitis...
- Lindane residues in cultivated cucumber and in the most consumed fish in Caspian Sea (Iran)M Shokrzadeh
Department of Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Toxicol Ind Health 25:517-23. 2009..of fish were caught using electric fishing from four major fishing centers (Chalous and Babolsar cities, Khazar Abad and Miankaleh regions) in Mazandaran province of Iran...
- Panel: Canada's law on global access to affordable medicinesTenu Avafia
United Nations Development Programme
HIV AIDS Policy Law Rev 14:76-83. 2009..agreements concerning intellectual property rights, which formed the basis of Canada's Access to Medicines Regime (CAMR)...
- Mitochondrial fatty acid beta-oxidation in the human eye and brain: implications for the retinopathy of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiencyTiina Tyni
Department of Pediatric Neurology, Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
Pediatr Res 56:744-50. 2004..MCAD) and very long-chain acyl-CoA dehydrogenase (VLCAD), short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), and mitochondrial trifunctional protein (MTP) harboring LCHAD...
- Characteristics of pediatric and adolescent patients attending a naturopathic college clinic in CanadaKumanan Wilson
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Pediatrics 115:e338-43. 2005..We also determined factors associated with the use of CAM products and vaccination status...
- Do lifestyle interventions work in developing countries? Findings from the Isfahan Healthy Heart Program in the Islamic Republic of IranNizal Sarrafzadegan
Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
Bull World Health Organ 87:39-50. 2009..To assess the effects of a comprehensive, integrated community-based lifestyle intervention on diet, physical activity and smoking in two Iranian communities...
- An overview of beta-oxidation disordersDariusz Moczulski
Katedra Medycyny Wewnetrznej, Uniwersytet Medyczny w Łodzi, Łódź
Postepy Hig Med Dosw (Online) 63:266-77. 2009..on disorders associated with fatty-acid oxidation: deficiencies of beta-oxidation enzymes, namely VLCAD, TFP and LCHAD, MCAD, MCKAT, M/SCHAD, and SCAD, and deficiencies of the enzymes TCP I, CT, and CPT II of the carnitine cycle.
- [The state of mental health primary care in the social services of El Alto, La Paz, Bolivia]Carmen Camacho-Arce
Instituto de Investigación de Psicología, Universidad Mayor de San Andres, La Paz, Bolivia
Rev Panam Salud Publica 25:511-7. 2009To determine the mental health and behavioral disorders (MHBD) treated by a Bolivian health network; and to gauge the perspective of the health professionals, community members, and care-providers in order to identify ways to better ..
- New assessment of relationship between Apgar score and early neonatal mortalityS Vahabi
Department Anesthesiology, Lorestan University of Medical Sciences, Khoramabad, Iran
Minerva Pediatr 62:249-52. 2010..We designed this study to examine the original intent of Apgar system to predict neonatal survival during almost 50 years of its application...
- Significant association between chronic antibody-mediated rejection and donor-specific antibodies against HLA-DRB rather than DQB in renal transplantationTakaaki Kobayashi
Department of Applied Immunology, Nagoya University School of Medicine, Nagoya, Japan
Hum Immunol 72:11-7. 2011..production of antidonor HLA antibody has been reported to be associated with chronic antibody-mediated rejection (CAMR). However, some donor-specific antibodies (DSA) do not seem to cause graft injury...
- Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidationAnders Molven
Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Diabetes 53:221-7. 2004..infant was recently found to have a mutation in the gene encoding short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), an enzyme participating in mitochondrial fatty acid oxidation...
- The closed/open model for lipase activation. Addressing intermediate active forms of fungal enzymes by trapping of conformers in water-restricted environmentsH Gonzalez-Navarro
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Valencia, E 46100 Burjassot, Spain
Biochemistry 40:3174-83. 2001..b>Abad, C., and Braco, L. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 3308-3312]...
- Morphological characterisation of Paranoplocephala bairdi (Schad, 1954) (Cestoda: Anoplocephalidae) in heather voles Phenacomys spp. and tree voles Arborimus spp., and related species in voles and lemmings (Muridae: Arvicolinae)Voitto Haukisalmi
Finnish Forest Research Institute, Vantaa Research Centre, P O Box 18, FIN 01301 Vantaa, Finland
Folia Parasitol (Praha) 52:311-21. 2005The taxonomical status of Paranoplocephala bairdi (Schad, 1954)-like cestodes (Anoplocephalidae) in heather voles Phenacomys spp. and tree voles Arborimus spp...
- Study of patients and carriers with 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: difficulties in the diagnosisJudit Garcia-Villoria
Sección de Errores Congénitos del Metabolismo IBC, Servicio de Bioquímica y Genética Molecular, and CIBER de Enfermedades Raras, Hospital Clinic, Barcelona, Spain
Clin Biochem 42:27-33. 2009To search for biochemical and molecular markers for the diagnosis of patients and carriers with 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency.
- Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patientsJoanna Ashton-Chess
INSERM, U643, Institut de Transplantation et de Recherche en Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes, France
J Am Soc Nephrol 20:1113-22. 2009..the graft and significantly decreased in the peripheral blood of patients with chronic antibody-mediated rejection (CAMR). Quantifying peripheral blood GrzB mRNA demonstrated potential to aid in the noninvasive diagnosis of CAMR...
- Prevalence of Cryptosporidium infection in camels (Camelus dromedarius) in a slaughterhouse in IranS M Razawi
Department of Parasitology, Veterinary School, Shiraz University, Shiraz, Iran
Trop Biomed 26:267-73. 2009..dromedarius) from Najaf-Abad slaughterhouse, Isfahan Province, central part of Iran...
- Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineagesUrsula Menzel
Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, London NW7 1AA, UK
Proc Natl Acad Sci U S A 107:16928-33. 2010..region (LCR) on the expression of a highly characterized, developmentally regulated locus, we have targeted the hCD2-LCR as a single copy into the endogenous mouse CD8 gene complex...
- Residues important for the function of a multihelical DNA binding domain in the new transcription factor family of Cam and Tet repressorsH Aramaki
Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan
Protein Eng 8:1259-66. 1995We report that some prokaryotic repressors including CamR and TetR belong to the same family...
- Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytesAnn M Ratchford
Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, MO 63110, USA
Am J Physiol Endocrinol Metab 293:E1198-206. 2007..enzyme activities of glucose-6-phosphate dehydrogenase (G6PDH), adenylate kinase, hydroxyacyl-CoA dehydrogenase (Hadh2), and glutamic pyruvate transaminase (Gpt2) were measured...
- Canada's Access to Medicines Regime: Promise or Failure of Humanitarian Effort?Jillian Clare Kohler
Assistant Professor, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON
Healthc Policy 5:40-8. 2010..One example is Canada's Access to Medicines Regime (CAMR)...
- Muscle-specific adaptations, impaired oxidative capacity and maintenance of contractile function characterize diet-induced obese mouse skeletal muscleKarin E Shortreed
Department of Pathology and Molecular Medicine, McMaster University, Hamilton Ontario, Canada
PLoS ONE 4:e7293. 2009..The effects of diet-induced obesity on skeletal muscle function are largely unknown, particularly as it relates to changes in oxidative metabolism and morphology...
- A one-time-only combination: Emergency medicine exports and the TRIPS agreement under Canada's access to medicines regimeAshley Weber
Stikeman Elliott LLP inToronto
Health Hum Rights 12:109-22. 2010..The shipment was authorized under Canada's Access to Medicines Regime (CAMR), which implements the World Trade Organization (WTO) General Council Decision (the Decision), made in 2003, to ..
- Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD)A J Powell
Department of Biochemistry, University of Bristol, Bristol, UK
J Mol Biol 303:311-27. 2000Human type II hydroxyacyl-CoA dehydrogenase/amyloid-beta binding alcohol dehydrogenase (HADH II/ABAD) is an oxidoreductase whose salient features include broad substrate specificity, encompassing 3-hydroxyacyl-CoA derivatives, ..
- L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's diseaseKim Tieu
Department of Neurology, Columbia University, New York, NY 10032, USA
Ann Neurol 56:51-60. 2004..Here, we report that L-3-hydroxyacyl-CoA dehydrogenase type II/amyloid binding alcohol dehydrogenase (HADH II/ABAD), a mitochondrial oxidoreductase enzyme involved in neuronal survival, is downregulated in PD patients and in MPTP-..
- Inhibition of energy metabolism by 2-methylacetoacetate and 2-methyl-3-hydroxybutyrate in cerebral cortex of developing ratsR B Rosa
Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
J Inherit Metab Dis 28:501-15. 2005Mitochondrial beta-ketothiolase and 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiencies are inherited neurometabolic disorders affecting isoleucine catabolism...
- The amyloid-β-SDR5C1(ABAD) interaction does not mediate a specific inhibition of mitochondrial RNase PElisa Vilardo
Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
PLoS ONE 8:e65609. 2013..The mitochondrial dehydrogenase SDR5C1 (also known as ABAD) was shown to bind Aβ and was proposed to thereby mediate mitochondrial toxicity, but the ..
- A type I interferon signature characterizes chronic antibody-mediated rejection in kidney transplantationFederica Rascio
Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale L Pinto 1, Foggia, Italy
J Pathol 237:72-84. 2015Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss...
- Medicaid managed care: are academic medical centers penalized by attracting patients with high-cost conditions?Michele Heisler
The Robert Wood Johnson Clinical Scholars Program, University of Michigan School of Medicine, Ann Arbor, Mich, USA
Am J Manag Care 9:19-29. 2003....
- 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency: impaired catabolism of isoleucine presenting as neurodegenerative diseaseJorn Oliver Sass
Stoffwechsellabor, Zentrum für Kinderheilkunde und Jugendmedizin, Universitatsklinikum Freiburg, Mathildenstr 1, D 79106, Freiburg, Germany
Brain Dev 26:12-4. 2004We describe a further case of recently reported 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency, a disorder of isoleucine metabolism...
- Genetics of congenital hyperinsulinismJean Christophe Fournet
Department of Pathology, Hopital Sainte Justine, Montreal, QC, Canada
Endocr Pathol 15:233-40. 2004..caused by mutations in genes coding for the beta-cell enzymes glucokinase (GK), glutamate dehydrogenase (GDH), and SCHAD. However, for as many as 50% of the cases, no genetic etiology has yet been determined...
- Mitochondrial dysfunction and Alzheimer's disease: role of amyloid-beta peptide alcohol dehydrogenase (ABAD)Shi Du Yan
Departments of Pathology, Surgery, Taub Institute for Research on Alzheimer s Disease and the Ageing Brain, College of Physicians and Surgeons of Columbia University, 650 West 168th Street, Black Building Rm 17 01, New York, NY 10032, USA
Int J Exp Pathol 86:161-71. 2005..potential significance of Abeta interaction with a mitochondrial enzyme termed Abeta-binding alcohol dehydrogenase (ABAD), a member of the short-chain dehydrogenase-reductase family concentrated in mitochondria of neurones...
- Introduction of Gerhard A. Schad as the recipient of the Clark P. Read Mentor AwardJohn M Hawdon
Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Medical Center, Washington, District of Columbia, USA
J Parasitol 91:1253-4. 2005
- Endophilin I expression is increased in the brains of Alzheimer disease patientsYimin Ren
Schools of Biology and Medicine, University of St Andrews, Scotland KY16 9TS
J Biol Chem 283:5685-91. 2008..have increased levels of both the 42 amyloid-beta-peptide (Abeta) and the amyloid binding alcohol dehydrogenase (ABAD), which is an intracellular binding site for Abeta...
- Ovariectomy increases neuronal amyloid-beta binding alcohol dehydrogenase level in the mouse hippocampusEmiko Fukuzaki
Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa, Japan
Neurochem Int 52:1358-64. 2008..we examined whether ovariectomy (OVX) could affect the levels of cofactors Abeta-binding alcohol dehydrogenase (ABAD) and receptor for advanced glycation endproducts (RAGE), which have been reported to potentiate Abeta-mediated ..
- The effect of type of marginal land use on the plant diversityA Ariapour
Range Science, Islamic Azad University, Science and Research Branch, Tehran, Iran
Pak J Biol Sci 11:813-6. 2008..The location of this study was Sar Firouze Abad region with rainfall of over 350 mm and slope of over 12%...
- Multifinger ab- and adduction strength and coordinationTodd C Pataky
School of Biomedical Sciences, University of Liverpool, Liverpool, UK
J Hand Ther 21:377-85. 2008..Twenty-one healthy subjects (12 female) produced maximal ab-/adduction (AbAd) efforts against a stationary apparatus equipped with four independent multiaxis force transducers...
- Association of the preoperative photoreceptor layer defect as assessed by optical coherence tomography with the functional outcome after macular hole closure: a long follow-up studyVlassis G Grigoropoulos
2nd Department of Ophthalmology, Henry Dunant Hospital, Athens, Greece
Ophthalmologica 225:47-54. 2011..to evaluate the correlation between the extent of the inner/outer segment (IS/OS) defect preoperatively and improvement in postoperative best-corrected visual acuity (BCVA) associated with IS/OS line restoration...
- Role of SLAM in NKT cell development revealed by transgenic complementation in NOD miceMargaret A Jordan
Comparative Genomics Centre, James Cook University, Townsville, Queensland 4811, Australia
J Immunol 186:3953-65. 2011..isoform of the C57BL/6 allele of Slamf1 was transgenically expressed on CD4(+)CD8(+) thymocytes under control of an hCD2 minigene. NOD.Nkrp1b...
- The effect of combination therapy with rituximab and intravenous immunoglobulin on the progression of chronic antibody mediated rejection in renal transplant recipientsGun Hee An
Division of Nephrology, Department of Internal Medicine, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
J Immunol Res 2014:828732. 2014The treatment for chronic active antibody-mediated rejection (CAMR) remains controversial. We investigated the efficacy of rituximab (RTX) and intravenous immunoglobulin (IVIg) for CAMR...
- Clinical outcome in patients with chronic antibody-mediated rejection treated with and without rituximab and intravenous immunoglobulin combination therapyByung Ha Chung
Transplant Research Center, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Division of Nephrology, Department of Internal Medicine, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Transpl Immunol 31:140-4. 2014..IVIg) combination therapy (RIT) is effective in treating patients with chronic active antibody-mediated rejection (CAMR), and the proteinuria level can determine the response to RIT...
- Treatment of visceral malperfusion in acute type B aortic dissection by percutaneous endovascular fenestration using a stent, with additional stenting of the true lumenHideki Miyachi
Division of Intensive and Cardiovascular Care Unit, Nippon Medical School Hospital
J Nippon Med Sch 81:340-5. 2014Patients with acute type B aortic dissection (ABAD) are often treated medically. However, ABAD is a potentially serious emergency if complicated by acute organ ischemia...
- Stented elephant trunk procedure with left subclavian artery transposition for acute type B dissection with distal arch involvementJun Ming Zhu
Beijing Aortic Disease Center, Beijing Institute of Heart, Lung and Blood Vessel Diseases and Beijing Anzhen Hospital, Capital Medical University, Beijing, China
J Thorac Cardiovasc Surg 150:1160-5. 2015..after thoracic endovascular aortic repair, is appealing treatment for complicated acute type B dissection (ABAD) with aortic arch involvement (AAI) because of reduced surgical trauma...
- Deciphering the role of TRIB1 in regulatory T-cellsRichard Danger
Institut National de la Santé et de la Recherche Médicale INSERM U1064 and Research Institute on Transplantation, Urology and Nephrology ITUN, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 01, France
Biochem Soc Trans 43:1075-8. 2015..reported to be overexpressed in the blood of renal transplanted patients with chronic antibody-mediated rejection (CAMR), altogether, these results suggest TRIB1 could be linked to the decrease proportion of Tregs in patients ..
- Contemporary Management of Acute Type B DissectionA J Scott
Department of Surgery and Cancer, Imperial College London, St Mary s Hospital, London, UK Imperial Vascular Unit, Imperial College Healthcare NHS Trust, St Mary s Hospital, UK
Eur J Vasc Endovasc Surg 51:452-9. 2016..In this review a clinical vignette to present a practical perspective on the contemporary management of acute type B dissection (ABAD) in a specialist vascular centre with particular focus on areas of debate is used.
- High substrate specificity of ipsdienol dehydrogenase (IDOLDH), a short-chain dehydrogenase from Ips pini bark beetlesRubi Figueroa-Teran
Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Reno, NV 89557, USA
J Biochem 160:141-51. 2016..structure: human L-3-hydroxyacyl-CoA dehydrogenase type II/ amyloid-β binding alcohol dehydrogenase (hHADH II/ABAD), and conducted functional assays of recombinant IDOLDH to determine substrate and product ranges and structural ..
- Mercury Release to Aquatic Environments from Anthropogenic Sources in China from 2001 to 2012Maodian Liu
Ministry of Education Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
Environ Sci Technol 50:8169-77. 2016Based on an analysis of measured data and distribution factors, we developed the China Aquatic Mercury Release (CAMR) model, which we used to calculate an inventory of mercury (Hg) that was released to aquatic environments from primary ..
- Negative regulation of HLA-DR expression on endothelial cells by anti-blood group A/B antibody ligation and mTOR inhibitionKenta Iwasaki
Department of Kidney Disease and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan Electronic address
Transpl Immunol . 2016..antibody (DSA), particularly against HLA class II, is a major cause of chronic antibody-mediated rejection (CAMR) after transplantation, although ABO-incompatible kidney transplantation has recently demonstrated favorable graft ..
- Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanismJ J Barycki
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis 55455, USA
Biochemistry 38:5786-98. 1999Human heart short chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) catalyzes the oxidation of the hydroxyl group of L-3-hydroxyacyl-CoA to a keto group, concomitant with the reduction of NAD+ to NADH, as part of the beta-oxidation pathway...
- Evidence for fatty acid oxidation in human placenta, and the relationship of fatty acid oxidation enzyme activities with gestational ageD Rakheja
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Placenta 23:447-50. 2002..metabolism, long chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) and short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), are active in the normal human placenta...
- 3-Hydroxy-2-methylbutyryl-CoA dehydrogenase deficiencyV R Sutton
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
J Inherit Metab Dis 26:69-71. 2003..Urine organic acid analysis revealed 3-hydroxy-2-methylbutyric acid and tiglyglycine; 3-ketothiolase enzyme activity was normal and he was subsequently found to have 3-hydroxy-2-methylbutyryl-CoA dehydrogenase deficiency...
- Type 10 17beta-hydroxysteroid dehydrogenase catalyzing the oxidation of steroid modulators of gamma-aminobutyric acid type A receptorsXue Ying He
Department of Neuropharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
Mol Cell Endocrinol 229:111-7. 2005..Immunoreactivity against 17beta-HSD10 was found in a number of neuronal populations. Taken together, evidence suggests that 17beta-HSD10 is the brain enzyme capable of catalyzing the oxidation of steroid modulators of GABA(A) receptors...
- [Theoretical basis in a sample of research projects carried out at the National School of Public Health, University of Antioquia, 1965-2004]Gustavo Cabrera Arana
Facultad Nacional de Salud Pública de la Universidad de Antioquia
Rev Salud Publica (Bogota) 7:99-111. 2005..the theoretical basis used in the studies carried out by students and lecturers of the undergraduate and postgraduate programs of the National School of Public Health "Hector Abad Gómez" of the University of Antioquia from 1965 to 2004.
- [Inhibition of neuronal death by promoting degradation of intracellular amyloid beta-protein]Yasumasa Ohyagi
Department School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Japan
Nihon Shinkei Seishin Yakurigaku Zasshi 27:57-62. 2007..Moreover, intraneuronal Ap is reported to induce mitochondrial dysfunction via binding ABAD, synaptic pathology, and inhibition of proteasome...
- NMR STUDIES OF PROTEIN TARGET INTERACTIONSGerhard Wagner; Fiscal Year: 2002..T antigen that interact with retinoblastoma protein and Hsc70; and the interaction of the T-cell surface proteins hCD2 and HCD58...
- Cellular Cofactors, Neuronal Stress & Rescue, Aging & Alzheimer DiseaseShi Du Yan; Fiscal Year: 2010..The central theme of our Program Project is that specific, cell associated cofactors, RAGE (Receptor for AGEs) and ABAD (A ?binding alcohol dehydrogenase) are critical for concentrating the effects of low levels of A, relevant to early ..
- Changchun Xiao; Fiscal Year: 2014..and autoimmune disease, and died prematurely, when this transgene was turned on in both B and T lymphocytes using hCD2-iCre...
- CHARLES ALFRED STANLEY; Fiscal Year: 2016..used to examine potential candidate genes, including the novel gene on 10q that will be identified in Aim 1, HADH/SCHAD, SLC16A1/MCT-1, TCF1/HNF1, TCF4/HNF4, SIR2L4/SIRT4, and others...
- Myra L Muramoto; Fiscal Year: 2014..chiropractors, and massage therapists (CAM practitioners) as part of the current NCI-funded CAM Reach Project (CAMR)...
- MITOCHONDRIAL SHORT CHAIN 3-OH-ACYL-COA DEHYDROGENASESArnold Strauss; Fiscal Year: 2003..This proposal focuses on two enzymes catalyzing the third step, the short chain 3-hydroxy-acyl-CoA dehydrogenases (SCHAD)...
- STRUCTURAL STUDIES OF LIPID/PROTEIN SYSTEMSLeonard Banaszak; Fiscal Year: 2002..beta-ketoacyl CoA reaction, humans have two different enzymes: one for short chain L-3-hydroxyacyl CoA substrates (SCHAD) and one for long chain metabolites (LCHAD). Preliminary x-ray data have identified the coenzyme site of SCHAD...
- The Role of RAGE and EAEShi Du Yan; Fiscal Year: 2005....
- ERAB, A BETA, NEUROTOXICITY AND ALZHEIMERS DISEASEShi Du Yan; Fiscal Year: 2003..We have identified a novel endoplasmic reticulum-associated Abeta binding protein termed ERAB which has properties of a b-hydroxyacyl-Coenzyme A dehydrogenase/short-chain alcohol dehydrogenase...
- International Medical Conference of Congenital HyperinsulinismCharles Stanley; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- PLACENTAL CARNITINE: ROLE IN FETAL DEVELOPMENTPrem Shekhawat; Fiscal Year: 2008..abstract_text> ..
- ISLET DYSREGULATION IN INFANTSCharles Stanley; Fiscal Year: 2008..The results of this research will provide essential information for improving the diagnosis and treatment of HI children and for understanding the basis of insulin regulation in normal humans. ..
- Ped Endocrine Career Development in Diabetes ResearchCharles Stanley; Fiscal Year: 2007..The Program is strongly supported by access to a superb range of institutional resources, including the CHOP GCRC and the UPenn DERC. Request is made for 2 Appointee slots in this Program each year. ..
- Peer Support--Congestive Heart Failure Self-ManagementMARY ELLEN HEISLER; Fiscal Year: 2009..If found effective, this approach could be used to improve health outcomes among patients with other chronic conditions, such as depression, chronic pain, or diabetes. ..
- Clinical Phenotype of Imprinted Genes of Chromosome 14Vernon Sutton; Fiscal Year: 2005..This phenotype delineation will lay the foundation for understanding the effects and pathogenesis of imprinted genes on chromosome 14. ..
- MOLECULAR BASIS OF A NEW FORM OF HYPERINSULINISMCHARLES ALFRED STANLEY; Fiscal Year: 2010..mutations of the mitochondrial fatty acid -oxidation enzyme, short-chain 3-hydroxy acyl-CoA dehydrogenase (SCHAD)...