HSD17B10

Summary

Gene Symbol: HSD17B10
Description: hydroxysteroid 17-beta dehydrogenase 10
Alias: 17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, 3-hydroxyacyl-CoA dehydrogenase type-2, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, AB-binding alcohol dehydrogenase, amyloid-beta peptide binding alcohol dehydrogenase, endoplasmic reticulum-associated amyloid beta-peptide-binding protein, mitochondrial RNase P subunit 2, mitochondrial ribonuclease P protein 2, short chain L-3-hydroxyacyl-CoA dehydrogenase type 2, short chain type dehydrogenase/reductase XH98G2
Species: human

Top Publications

  1. ncbi Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence
    P J Vredendaal
    Department for Metabolic Diseases, Wilhelmina Childrens Hospital, Utrecht, The Netherlands
    Biochem Biophys Res Commun 223:718-23. 1996
  2. doi Genetic polymorphisms of 17 β-hydroxysteroid dehydrogenase 3 and the risk of hypospadias
    Fumihiro Sata
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Sex Med 7:2729-38. 2010
  3. ncbi 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: an X-linked inborn error of isoleucine metabolism that may mimic a mitochondrial disease
    Celia Perez-Cerda
    Institut de Bioquímica, Corporaciò Sanitària Cláinic, Edifici Helios III, 08028 Barcelona, Spain
    Pediatr Res 58:488-91. 2005
  4. ncbi 3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease
    Song Yu Yang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    FEBS J 272:4874-83. 2005
  5. ncbi An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease
    S D Yan
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 389:689-95. 1997
  6. ncbi A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease
    X Y He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Biol Chem 273:10741-6. 1998
  7. ncbi Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity
    S D Yan
    Departments of Pathology, Physiology and Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Biol Chem 274:2145-56. 1999
  8. ncbi Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase
    X Y He
    Departments of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Biol Chem 274:15014-9. 1999
  9. ncbi Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease
    U C Oppermann
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    FEBS Lett 451:238-42. 1999
  10. ncbi Characterization and localization of human type10 17beta-hydroxysteroid dehydrogenase
    X Y He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, New York 10314, USA
    Eur J Biochem 268:4899-907. 2001

Research Grants

  1. NMR STUDIES OF PROTEIN TARGET INTERACTIONS
    Gerhard Wagner; Fiscal Year: 2002
  2. Cellular Cofactors, Neuronal Stress & Rescue, Aging & Alzheimer Disease
    Shi Du Yan; Fiscal Year: 2010
  3. Changchun Xiao; Fiscal Year: 2014
  4. CHARLES ALFRED STANLEY; Fiscal Year: 2016
  5. Myra L Muramoto; Fiscal Year: 2014
  6. MITOCHONDRIAL SHORT CHAIN 3-OH-ACYL-COA DEHYDROGENASES
    Arnold Strauss; Fiscal Year: 2003
  7. STRUCTURAL STUDIES OF LIPID/PROTEIN SYSTEMS
    Leonard Banaszak; Fiscal Year: 2002
  8. The Role of RAGE and EAE
    Shi Du Yan; Fiscal Year: 2005
  9. ERAB, A BETA, NEUROTOXICITY AND ALZHEIMERS DISEASE
    Shi Du Yan; Fiscal Year: 2003
  10. International Medical Conference of Congenital Hyperinsulinism
    Charles Stanley; Fiscal Year: 2006

Detail Information

Publications191 found, 100 shown here

  1. ncbi Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence
    P J Vredendaal
    Department for Metabolic Diseases, Wilhelmina Childrens Hospital, Utrecht, The Netherlands
    Biochem Biophys Res Commun 223:718-23. 1996
    The cDNA encompassing the complete coding sequence of human liver short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) was isolated and characterized...
  2. doi Genetic polymorphisms of 17 β-hydroxysteroid dehydrogenase 3 and the risk of hypospadias
    Fumihiro Sata
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Sex Med 7:2729-38. 2010
    ..In this regard, enzymes 17 β-hydroxysteroid dehydrogenase type 3 (17 β HSD3, encoded by HSD17B3) and steroid 5 α-reductase type 2 (encoded by SRD5A2) play crucial roles...
  3. ncbi 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: an X-linked inborn error of isoleucine metabolism that may mimic a mitochondrial disease
    Celia Perez-Cerda
    Institut de Bioquímica, Corporaciò Sanitària Cláinic, Edifici Helios III, 08028 Barcelona, Spain
    Pediatr Res 58:488-91. 2005
    We describe three patients, from two Spanish families, with 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency, a recently described X-linked neurodegenerative inborn error of isoleucine metabolism...
  4. ncbi 3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease
    Song Yu Yang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    FEBS J 272:4874-83. 2005
    ..HAD has a preference for medium chain substrates, whereas short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) acts on a wide spectrum of substrates, including steroids, cholic acids, and fatty acids, with a preference for ..
  5. ncbi An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease
    S D Yan
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 389:689-95. 1997
    ..It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in ..
  6. ncbi A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease
    X Y He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Biol Chem 273:10741-6. 1998
    ..of this human brain enzyme is identical to that of an endoplasmic reticulum amyloid beta-peptide-binding protein (ERAB), which mediates neurotoxicity in Alzheimer's disease (Yan, S. D., Fu, J., Soto, C., Chen, X., Zhu, H...
  7. ncbi Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity
    S D Yan
    Departments of Pathology, Physiology and Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Biol Chem 274:2145-56. 1999
    Endoplasmic reticulum-associated amyloid beta-peptide (Abeta)-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II (HADH II) is expressed at high levels in Alzheimer's disease (AD)-affected brain, binds Abeta, and contributes ..
  8. ncbi Human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase is a single-domain multifunctional enzyme. Characterization of a novel 17beta-hydroxysteroid dehydrogenase
    X Y He
    Departments of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Biol Chem 274:15014-9. 1999
    Human brain short chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) was found to catalyze the oxidation of 17beta-estradiol and dihydroandrosterone as well as alcohols...
  9. ncbi Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease
    U C Oppermann
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    FEBS Lett 451:238-42. 1999
    The intracellular amyloid beta-peptide (A beta) binding protein, ERAB, a member of the short-chain dehydrogenase/reductase (SDR) family, is known to mediate apoptosis in different cell lines and to be a class II hydroxyacyl-CoA ..
  10. ncbi Characterization and localization of human type10 17beta-hydroxysteroid dehydrogenase
    X Y He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, New York 10314, USA
    Eur J Biochem 268:4899-907. 2001
    ..studies demonstrate that this protein, which has been referred to as ER-associated amyloid beta-binding protein (ERAB), is not detectable in the ER of normal tissues...
  11. ncbi Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain Res Mol Brain Res 99:46-53. 2002
    ..reticulum as suggested by its trivial name 'endoplasmic reticulum-associated amyloid-beta biding protein (ERAB)'...
  12. pmc 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene
    Rob Ofman
    Department of Clinical Chemistry, Academic Medical Center, Emma Children s Hospital, University of Amsterdam, The Netherlands
    Am J Hum Genet 72:1300-7. 2003
    ..This led to the identification of the X-chromosomal gene involved, which previously had been denoted "HADH2." Sequence analysis of the HADH2 gene from patients with MHBD deficiency revealed the presence of two missense ..
  13. pmc Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-H
    Naeem Shafqat
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Biochem J 376:49-60. 2003
    ....
  14. ncbi Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Steroid Biochem Mol Biol 87:191-8. 2003
    ..The experimental results lead to the conclusion that mitochondrial 17beta-HSD10 plays a significant part in a non-classical androgen synthesis pathway along with microsomal retinol dehydrogenases...
  15. ncbi ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
    Joyce W Lustbader
    Center for Reproductive Sciences and Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Science 304:448-52. 2004
    ..Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity...
  16. ncbi Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics
    Charles R Kissinger
    Pfizer La Jolla, 10777 Science Center Dr, San Diego, CA 92121, USA
    J Mol Biol 342:943-52. 2004
    ..dehydrogenase type 10 (HSD10), also known as amyloid beta-peptide-binding alcohol dehydrogenase (ABAD), has been implicated in the development of Alzheimer's disease...
  17. ncbi ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction
    Kazuhiro Takuma
    Departments of Surgery, Pathology, and Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    FASEB J 19:597-8. 2005
    Amyloid-beta peptide (Abeta) binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, is a cofactor facilitating Abeta-induced cell stress...
  18. ncbi Intracellular oxidation of allopregnanolone by human brain type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain Res 1040:29-35. 2005
    ..The elevated level of 17beta-HSD10 in activated astrocytes is a new feature found in brains of people with AD, and it may have important impact on AD pathogenesis...
  19. ncbi HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids
    Song Yu Yang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Mol Genet Metab 92:36-42. 2007
    The HSD17B10 gene maps on chromosome Xp11.2, a region highly associated with X-linked mental retardation...
  20. doi RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme
    Johann Holzmann
    Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria
    Cell 135:462-74. 2008
    ..Apparently, animal mitochondria lost the seemingly ubiquitous RNA world remnant after reinventing RNase P from preexisting components...
  21. pmc Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolism
    Song Yu Yang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Proc Natl Acad Sci U S A 106:14820-4. 2009
    Mutations in the HSD17B10 gene were identified in two previously described mentally retarded males. A point mutation c.776G>C was found from a survivor (SV), whereas a potent mutation, c...
  22. doi Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis
    Zdena Kristofikova
    Alzheimer Disease Center, Prague Psychiatric Centre, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic
    Mol Biosyst 5:1174-9. 2009
    ..In patients with multiple sclerosis, our results are the first to demonstrate significant changes in enzyme expression and to suggest possible alterations in amyloid beta peptides...
  23. pmc A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival
    Katharina Rauschenberger
    Institute of Human Genetics, Heidelberg University, Heidelberg, Germany
    EMBO Mol Med 2:51-62. 2010
    ..The disease-causing gene is HSD17B10 and encodes 17beta-hydroxysteroid dehydrogenase type 10 (HSD10), a protein also implicated in the pathogenesis of ..
  24. doi Type 10 17β-hydroxysteroid dehydrogenase expression is regulated by C/EBPβ in HepG2 cells
    Mirja Rotinen
    Department of Health Sciences, Universidad Publica de Navarra, Avda Barañain, 31008 Pamplona, Spain
    J Steroid Biochem Mol Biol 122:164-71. 2010
    ..C/EBPα or C/EBPβ in HepG2 cells showed that HSD17B11 expression was induced by both transcription factors while HSD17B10 expression was only induced by C/EBPβ...
  25. pmc X-inactivation of HSD17B10 revealed by cDNA analysis in two female patients with 17β-hydroxysteroid dehydrogenase 10 deficiency
    Judit Garcia-Villoria
    Sección de Errores Congénitos del Metabolismo IBC, Servicio de Bioquímica y Genética Molecular, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Eur J Hum Genet 18:1353-5. 2010
    ..The gene encoding HSD10, HSD17B10, has been reported as one of the few genes that escapes X-inactivation...
  26. doi Behavioral stress causes mitochondrial dysfunction via ABAD up-regulation and aggravates plaque pathology in the brain of a mouse model of Alzheimer disease
    Ji Seon Seo
    Department of Brain and Cognitive Sciences, Ewha Women s University, Seoul 120 750, Republic of Korea
    Free Radic Biol Med 50:1526-35. 2011
    ..corticosterone) and Aβ in SH-SY5Y cells increased the expression of 17β-hydroxysteroid dehydrogenase (ABAD), mitochondrial dysfunction, and levels of ROS, whereas blockade of ABAD expression by siRNA-ABAD in SH-SY5Y cells ..
  27. pmc A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis
    Elisa Vilardo
    Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria
    Nucleic Acids Res 40:11583-93. 2012
    ..Human mitochondrial RNase P, thus, constitutes a multifunctional complex, whose subunits moonlight in cascade: a fatty and amino acid degradation enzyme in tRNA methylation and the methyltransferase, in turn, in tRNA 5' end processing...
  28. doi A 5-methylcytosine hotspot responsible for the prevalent HSD17B10 mutation
    Song Yu Yang
    Department of Developmental Biochemistry, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Gene 515:380-4. 2013
    ..hydroxysteroid (17β) dehydrogenase X (HSD10) deficiency are due to a missense C>T mutation in exon 4 of the HSD17B10 gene. The resulting HSD10 (p...
  29. pmc Chromosomal basis of X chromosome inactivation: identification of a multigene domain in Xp11.21-p11.22 that escapes X inactivation
    A P Miller
    Department of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 95:8709-14. 1998
    ..Genes located both distal and proximal to this cluster are subject to inactivation, thereby defining a unique multigene domain on the proximal short arm that is transcriptionally active on the inactive X chromosome...
  30. pmc Comparative evolutionary genomics of the HADH2 gene encoding Abeta-binding alcohol dehydrogenase/17beta-hydroxysteroid dehydrogenase type 10 (ABAD/HSD10)
    Alexandra T Marques
    REQUIMTE, Departamento de Quimica, Faculdade de Ciencias, Universidade do Porto, Rua do Campo Alegre, 687, 4169 007 Porto, Portugal
    BMC Genomics 7:202. 2006
    ..Here we use comparative genomic analyses to study the evolution of the HADH2 gene encoding ABAD/HSD10 across several eukaryotic species.
  31. pmc The reduced expression of the HADH2 protein causes X-linked mental retardation, choreoathetosis, and abnormal behavior
    Claus Lenski
    Department of Obstetrics and Gynecology, Technical University, Munich, Germany
    Am J Hum Genet 80:372-7. 2007
    ..with a unique clinical phenotype characterized by mild mental retardation, choreoathetosis, and abnormal behavior (MRXS10). Linkage analysis in this family revealed a candidate region of 13...
  32. doi Estrogen receptor alpha interacts with 17beta-hydroxysteroid dehydrogenase type 10 in mitochondria
    Virginija Jazbutyte
    Laboratory of Molecular Cardiology, Department of Medicine, University Clinics Wuerzburg, Josef Schneider Strasse 2, D20, 97080 Wuerzburg, Germany
    Biochem Biophys Res Commun 384:450-4. 2009
    ..GST pull-down experiments confirmed the interaction of ERalpha and 17beta-HSD10. These findings suggest that the ERalpha estrogen receptor might be involved in regulating intracellular estrogen levels by modulating 17beta-HSD10 activity...
  33. ncbi Cloning and expression of cDNA for a newly identified isozyme of bovine liver 3-hydroxyacyl-CoA dehydrogenase and its import into mitochondria
    S Furuta
    Department of Biochemistry, Shinshu University School of Medicine, Nagano, Japan
    Biochim Biophys Acta 1350:317-24. 1997
    ....
  34. pmc Framing access to medicines in developing countries: an analysis of media coverage of Canada's Access to Medicines Regime
    Laura C Esmail
    Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada
    BMC Int Health Hum Rights 10:1. 2010
    ..Over the course of eight months, the legislation, now known as Canada's Access to Medicines Regime (CAMR), went through a controversial policy development process and the newspaper media was one of the major venues in ..
  35. ncbi Dominantly inherited hyperinsulinaemic hypoglycaemia
    P de Lonlay
    INSERM U393 and Department of Pediatrics, Hopital Necker Enfants Malades, Paris, France
    J Inherit Metab Dis 28:267-76. 2005
    ..dominantly inherited HI; (ii) metabolic disorders implicating the short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) enzyme inrecessively inherited HI, the glucokinase gene (GK), the glutamate dehydrogenase gene (GLUD1) when ..
  36. ncbi The benefits and costs of reducing emissions from the electricity sector
    Karen Palmer
    Resources for the Future, 1616 P Street, NW, Washington, DC 20036, USA
    J Environ Manage 83:115-30. 2007
    ..Rule (CAIR) as characterized in the supplemental rule proposed in June 2004, and the Clean Air Mercury Rule (CAMR) as proposed in February 2004...
  37. ncbi Effect of sowing dates on yield and yield components of spring safflower (Carthamus tinctorius L.) in Isfahan region
    S Nikabadi
    Department of Agronomy, Faculty of Agriculture, Islamic Azad University, Branch of Khorasgan, Isfahan, Iran
    Pak J Biol Sci 11:1953-6. 2008
    ..of two safflower varieties, an experiment was conducted at Agriculture Research Station of Isfahan Kabotar Abad in 2004...
  38. ncbi Regional localisation of two non-specific X-linked mental retardation genes (MRX30 and MRX31)
    A J Donnelly
    Department of Cytogenetics and Molecular Genetics, Women s and Children s Hospital, Adelaide, Australia
    Am J Med Genet 64:113-20. 1996
    ..3) and DXS424 (Xq24). A significant multipoint lod score of 2.78 was detected between the loci DXS1120 and DXS456. MRX31 maps to a 12 cM region that spans the centromere from DXS1126 (Xp11.23) to DXS1124 (Xq13.3)...
  39. ncbi Indoor radon levels and lung cancer risk estimates in seven cities of the Bahawalpur Division, Pakistan
    - Matiullah
    Pakistan Institute of Engineering and Applied Sciences, P O Nilore, Islamabad, Pakistan
    Radiat Prot Dosimetry 107:269-76. 2003
    ..These included Fort Abbas, Minchin Abad, Hasilpur, Bahawalpur, Liaqatpur, Rahimyar Khan and Sadiq Abad...
  40. pmc Variants of smooth Salmonella enterica serovar Enteritidis that grow to higher cell density than the wild type are more virulent
    J Guard-Petter
    Agricultural Research Service, United States Department of Agriculture, Athens, Georgia 30605, USA
    Appl Environ Microbiol 64:2166-72. 1998
    ..Whereas SE-HCD1 killed 70% of 6-day-old chicks challenged subcutaneously, the same dose of SE-HCD2 did not kill any chicks...
  41. pmc Transcription of the cam operon and camR genes in Pseudomonas putida PpG1
    M Fujita
    Department of Biotechnology, Faculty of Engineering, Fukuyama University, Hiroshima, Japan
    J Bacteriol 175:6953-8. 1993
    ..operon (camDCAB) encoding enzymes involved in the degradation pathway of D-camphor is negatively regulated by the CamR protein, and camR is autorepressed...
  42. ncbi Reye-like syndrome resulting from novel missense mutations in mitochondrial medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase
    Michael J Bennett
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Mol Genet Metab 89:74-9. 2006
    Medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase (M/SCHAD) deficiency is a recessively inherited disorder of fatty acid oxidation. Currently, only four patients from three families have been reported in the literature...
  43. ncbi Crystal structure of the TetR/CamR family repressor Mycobacterium tuberculosis EthR implicated in ethionamide resistance
    Lynn G Dover
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Mol Biol 340:1095-105. 2004
    ..Activation of the pro-drug ethionamide is regulated by the Baeyer-Villiger monooxygenase EthA and the TetR/CamR family repressor EthR, whose open reading frames are separated by 75 bp on the Mycobacterium tuberculosis genome...
  44. ncbi Soil contamination with Toxocara spp. eggs in the public parks from three areas of Khorram Abad, Iran
    M Zibaei
    Department of Parasitology, School of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran
    Nepal Med Coll J 12:63-5. 2010
    ..The present investigation clearly shows that public parks have been contaminated with Toxocara eggs in Khorram Abad, suggesting that care should be taken when using public parks.
  45. pmc Deletion of new covalently linked cell wall glycoproteins alters the electrophoretic mobility of phosphorylated wall components of Saccharomyces cerevisiae
    V Mrsa
    Lehrstuhl für Zellbiologie und Pflanzenphysiologie, Universitat Regensburg, 93040 Regensburg, Germany
    J Bacteriol 181:3076-86. 1999
    ..Moukadiri, J. Armero, A. Abad, R. Sentandreu, and J. Zueco, J. Bacteriol. 179:2154-2162, 1997)...
  46. ncbi Isfahan Healthy Heart Programme: a comprehensive integrated community-based programme for cardiovascular disease prevention and control. Design, methods and initial experience
    Nizal Sarraf-Zadegan
    Isfahan Cardiovascular Center, Isfahan University of Medical Sciences, Isfahan, Iran
    Acta Cardiol 58:309-20. 2003
    ..A primary survey was done to collect baseline data from interventional (Isfahan and Najaf-Abad) and reference (Arak) communities...
  47. ncbi Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase
    A Goodwin
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Mol Microbiol 28:383-93. 1998
    ..pylori rendered it MtzS; and (iii) replacement of rdxA in MtzS H. pylori with an rdxA::camR null insertion allele resulted in a MtzR phenotype. The 630 bp rdxA genes of five pairs of H...
  48. doi Evidence that 2-methylacetoacetate induces oxidative stress in rat brain
    Guilhian Leipnitz
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal de Rio Grande do Sul, Rua Ramiro Barcelos, Anexo, Porto Alegre, RS, Brazil
    Metab Brain Dis 25:261-7. 2010
    ..in mitochondrial 2-methylacetoacetyl-CoA thiolase (KT) and 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiencies, on important parameters of oxidative stress in cerebral cortex from young rats...
  49. doi Fluorodeoxyglucose positron emission tomography for the diagnosis of sarcoidosis in patients with unexplained chronic uveitis
    Pascal Seve
    Department of Internal Medicine, Hotel Dieu, Hospices Civils de Lyon, Lyon, France
    Ocul Immunol Inflamm 17:179-84. 2009
    ..To assess the value of fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in patients with unexplained chronic uveitis...
  50. doi Lindane residues in cultivated cucumber and in the most consumed fish in Caspian Sea (Iran)
    M Shokrzadeh
    Department of Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
    Toxicol Ind Health 25:517-23. 2009
    ..of fish were caught using electric fishing from four major fishing centers (Chalous and Babolsar cities, Khazar Abad and Miankaleh regions) in Mazandaran province of Iran...
  51. ncbi Panel: Canada's law on global access to affordable medicines
    Tenu Avafia
    United Nations Development Programme
    HIV AIDS Policy Law Rev 14:76-83. 2009
    ..agreements concerning intellectual property rights, which formed the basis of Canada's Access to Medicines Regime (CAMR)...
  52. ncbi Mitochondrial fatty acid beta-oxidation in the human eye and brain: implications for the retinopathy of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency
    Tiina Tyni
    Department of Pediatric Neurology, Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    Pediatr Res 56:744-50. 2004
    ..MCAD) and very long-chain acyl-CoA dehydrogenase (VLCAD), short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), and mitochondrial trifunctional protein (MTP) harboring LCHAD...
  53. ncbi Characteristics of pediatric and adolescent patients attending a naturopathic college clinic in Canada
    Kumanan Wilson
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Pediatrics 115:e338-43. 2005
    ..We also determined factors associated with the use of CAM products and vaccination status...
  54. pmc Do lifestyle interventions work in developing countries? Findings from the Isfahan Healthy Heart Program in the Islamic Republic of Iran
    Nizal Sarrafzadegan
    Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
    Bull World Health Organ 87:39-50. 2009
    ..To assess the effects of a comprehensive, integrated community-based lifestyle intervention on diet, physical activity and smoking in two Iranian communities...
  55. ncbi An overview of beta-oxidation disorders
    Dariusz Moczulski
    Katedra Medycyny Wewnetrznej, Uniwersytet Medyczny w Łodzi, Łódź
    Postepy Hig Med Dosw (Online) 63:266-77. 2009
    ..on disorders associated with fatty-acid oxidation: deficiencies of beta-oxidation enzymes, namely VLCAD, TFP and LCHAD, MCAD, MCKAT, M/SCHAD, and SCAD, and deficiencies of the enzymes TCP I, CT, and CPT II of the carnitine cycle.
  56. ncbi [The state of mental health primary care in the social services of El Alto, La Paz, Bolivia]
    Carmen Camacho-Arce
    Instituto de Investigación de Psicología, Universidad Mayor de San Andres, La Paz, Bolivia
    Rev Panam Salud Publica 25:511-7. 2009
    To determine the mental health and behavioral disorders (MHBD) treated by a Bolivian health network; and to gauge the perspective of the health professionals, community members, and care-providers in order to identify ways to better ..
  57. ncbi New assessment of relationship between Apgar score and early neonatal mortality
    S Vahabi
    Department Anesthesiology, Lorestan University of Medical Sciences, Khoramabad, Iran
    Minerva Pediatr 62:249-52. 2010
    ..We designed this study to examine the original intent of Apgar system to predict neonatal survival during almost 50 years of its application...
  58. doi Significant association between chronic antibody-mediated rejection and donor-specific antibodies against HLA-DRB rather than DQB in renal transplantation
    Takaaki Kobayashi
    Department of Applied Immunology, Nagoya University School of Medicine, Nagoya, Japan
    Hum Immunol 72:11-7. 2011
    ..production of antidonor HLA antibody has been reported to be associated with chronic antibody-mediated rejection (CAMR). However, some donor-specific antibodies (DSA) do not seem to cause graft injury...
  59. ncbi Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation
    Anders Molven
    Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    Diabetes 53:221-7. 2004
    ..infant was recently found to have a mutation in the gene encoding short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), an enzyme participating in mitochondrial fatty acid oxidation...
  60. ncbi The closed/open model for lipase activation. Addressing intermediate active forms of fungal enzymes by trapping of conformers in water-restricted environments
    H Gonzalez-Navarro
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Valencia, E 46100 Burjassot, Spain
    Biochemistry 40:3174-83. 2001
    ..b>Abad, C., and Braco, L. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 3308-3312]...
  61. ncbi Morphological characterisation of Paranoplocephala bairdi (Schad, 1954) (Cestoda: Anoplocephalidae) in heather voles Phenacomys spp. and tree voles Arborimus spp., and related species in voles and lemmings (Muridae: Arvicolinae)
    Voitto Haukisalmi
    Finnish Forest Research Institute, Vantaa Research Centre, P O Box 18, FIN 01301 Vantaa, Finland
    Folia Parasitol (Praha) 52:311-21. 2005
    The taxonomical status of Paranoplocephala bairdi (Schad, 1954)-like cestodes (Anoplocephalidae) in heather voles Phenacomys spp. and tree voles Arborimus spp...
  62. doi Study of patients and carriers with 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: difficulties in the diagnosis
    Judit Garcia-Villoria
    Sección de Errores Congénitos del Metabolismo IBC, Servicio de Bioquímica y Genética Molecular, and CIBER de Enfermedades Raras, Hospital Clinic, Barcelona, Spain
    Clin Biochem 42:27-33. 2009
    To search for biochemical and molecular markers for the diagnosis of patients and carriers with 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency.
  63. pmc Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients
    Joanna Ashton-Chess
    INSERM, U643, Institut de Transplantation et de Recherche en Transplantation, Centre Hospitalier Universitaire de Nantes, Nantes, France
    J Am Soc Nephrol 20:1113-22. 2009
    ..the graft and significantly decreased in the peripheral blood of patients with chronic antibody-mediated rejection (CAMR). Quantifying peripheral blood GrzB mRNA demonstrated potential to aid in the noninvasive diagnosis of CAMR...
  64. ncbi Prevalence of Cryptosporidium infection in camels (Camelus dromedarius) in a slaughterhouse in Iran
    S M Razawi
    Department of Parasitology, Veterinary School, Shiraz University, Shiraz, Iran
    Trop Biomed 26:267-73. 2009
    ..dromedarius) from Najaf-Abad slaughterhouse, Isfahan Province, central part of Iran...
  65. pmc Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages
    Ursula Menzel
    Division of Molecular Immunology, National Institute for Medical Research, Medical Research Council, London NW7 1AA, UK
    Proc Natl Acad Sci U S A 107:16928-33. 2010
    ..region (LCR) on the expression of a highly characterized, developmentally regulated locus, we have targeted the hCD2-LCR as a single copy into the endogenous mouse CD8 gene complex...
  66. ncbi Residues important for the function of a multihelical DNA binding domain in the new transcription factor family of Cam and Tet repressors
    H Aramaki
    Daiichi College of Pharmaceutical Sciences, Fukuoka, Japan
    Protein Eng 8:1259-66. 1995
    We report that some prokaryotic repressors including CamR and TetR belong to the same family...
  67. ncbi Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes
    Ann M Ratchford
    Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 293:E1198-206. 2007
    ..enzyme activities of glucose-6-phosphate dehydrogenase (G6PDH), adenylate kinase, hydroxyacyl-CoA dehydrogenase (Hadh2), and glutamic pyruvate transaminase (Gpt2) were measured...
  68. pmc Canada's Access to Medicines Regime: Promise or Failure of Humanitarian Effort?
    Jillian Clare Kohler
    Assistant Professor, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON
    Healthc Policy 5:40-8. 2010
    ..One example is Canada's Access to Medicines Regime (CAMR)...
  69. pmc Muscle-specific adaptations, impaired oxidative capacity and maintenance of contractile function characterize diet-induced obese mouse skeletal muscle
    Karin E Shortreed
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton Ontario, Canada
    PLoS ONE 4:e7293. 2009
    ..The effects of diet-induced obesity on skeletal muscle function are largely unknown, particularly as it relates to changes in oxidative metabolism and morphology...
  70. ncbi A one-time-only combination: Emergency medicine exports and the TRIPS agreement under Canada's access to medicines regime
    Ashley Weber
    Stikeman Elliott LLP inToronto
    Health Hum Rights 12:109-22. 2010
    ..The shipment was authorized under Canada's Access to Medicines Regime (CAMR), which implements the World Trade Organization (WTO) General Council Decision (the Decision), made in 2003, to ..
  71. ncbi Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD)
    A J Powell
    Department of Biochemistry, University of Bristol, Bristol, UK
    J Mol Biol 303:311-27. 2000
    Human type II hydroxyacyl-CoA dehydrogenase/amyloid-beta binding alcohol dehydrogenase (HADH II/ABAD) is an oxidoreductase whose salient features include broad substrate specificity, encompassing 3-hydroxyacyl-CoA derivatives, ..
  72. ncbi L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease
    Kim Tieu
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Ann Neurol 56:51-60. 2004
    ..Here, we report that L-3-hydroxyacyl-CoA dehydrogenase type II/amyloid binding alcohol dehydrogenase (HADH II/ABAD), a mitochondrial oxidoreductase enzyme involved in neuronal survival, is downregulated in PD patients and in MPTP-..
  73. ncbi Inhibition of energy metabolism by 2-methylacetoacetate and 2-methyl-3-hydroxybutyrate in cerebral cortex of developing rats
    R B Rosa
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Inherit Metab Dis 28:501-15. 2005
    Mitochondrial beta-ketothiolase and 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiencies are inherited neurometabolic disorders affecting isoleucine catabolism...
  74. pmc The amyloid-β-SDR5C1(ABAD) interaction does not mediate a specific inhibition of mitochondrial RNase P
    Elisa Vilardo
    Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
    PLoS ONE 8:e65609. 2013
    ..The mitochondrial dehydrogenase SDR5C1 (also known as ABAD) was shown to bind Aβ and was proposed to thereby mediate mitochondrial toxicity, but the ..
  75. doi A type I interferon signature characterizes chronic antibody-mediated rejection in kidney transplantation
    Federica Rascio
    Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale L Pinto 1, Foggia, Italy
    J Pathol 237:72-84. 2015
    Chronic antibody-mediated rejection (CAMR) represents the main cause of kidney graft loss...
  76. ncbi Medicaid managed care: are academic medical centers penalized by attracting patients with high-cost conditions?
    Michele Heisler
    The Robert Wood Johnson Clinical Scholars Program, University of Michigan School of Medicine, Ann Arbor, Mich, USA
    Am J Manag Care 9:19-29. 2003
    ....
  77. ncbi 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency: impaired catabolism of isoleucine presenting as neurodegenerative disease
    Jorn Oliver Sass
    Stoffwechsellabor, Zentrum für Kinderheilkunde und Jugendmedizin, Universitatsklinikum Freiburg, Mathildenstr 1, D 79106, Freiburg, Germany
    Brain Dev 26:12-4. 2004
    We describe a further case of recently reported 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency, a disorder of isoleucine metabolism...
  78. ncbi Genetics of congenital hyperinsulinism
    Jean Christophe Fournet
    Department of Pathology, Hopital Sainte Justine, Montreal, QC, Canada
    Endocr Pathol 15:233-40. 2004
    ..caused by mutations in genes coding for the beta-cell enzymes glucokinase (GK), glutamate dehydrogenase (GDH), and SCHAD. However, for as many as 50% of the cases, no genetic etiology has yet been determined...
  79. pmc Mitochondrial dysfunction and Alzheimer's disease: role of amyloid-beta peptide alcohol dehydrogenase (ABAD)
    Shi Du Yan
    Departments of Pathology, Surgery, Taub Institute for Research on Alzheimer s Disease and the Ageing Brain, College of Physicians and Surgeons of Columbia University, 650 West 168th Street, Black Building Rm 17 01, New York, NY 10032, USA
    Int J Exp Pathol 86:161-71. 2005
    ..potential significance of Abeta interaction with a mitochondrial enzyme termed Abeta-binding alcohol dehydrogenase (ABAD), a member of the short-chain dehydrogenase-reductase family concentrated in mitochondria of neurones...
  80. ncbi Introduction of Gerhard A. Schad as the recipient of the Clark P. Read Mentor Award
    John M Hawdon
    Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Medical Center, Washington, District of Columbia, USA
    J Parasitol 91:1253-4. 2005
  81. doi Endophilin I expression is increased in the brains of Alzheimer disease patients
    Yimin Ren
    Schools of Biology and Medicine, University of St Andrews, Scotland KY16 9TS
    J Biol Chem 283:5685-91. 2008
    ..have increased levels of both the 42 amyloid-beta-peptide (Abeta) and the amyloid binding alcohol dehydrogenase (ABAD), which is an intracellular binding site for Abeta...
  82. pmc Ovariectomy increases neuronal amyloid-beta binding alcohol dehydrogenase level in the mouse hippocampus
    Emiko Fukuzaki
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa, Japan
    Neurochem Int 52:1358-64. 2008
    ..we examined whether ovariectomy (OVX) could affect the levels of cofactors Abeta-binding alcohol dehydrogenase (ABAD) and receptor for advanced glycation endproducts (RAGE), which have been reported to potentiate Abeta-mediated ..
  83. ncbi The effect of type of marginal land use on the plant diversity
    A Ariapour
    Range Science, Islamic Azad University, Science and Research Branch, Tehran, Iran
    Pak J Biol Sci 11:813-6. 2008
    ..The location of this study was Sar Firouze Abad region with rainfall of over 350 mm and slope of over 12%...
  84. pmc Multifinger ab- and adduction strength and coordination
    Todd C Pataky
    School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    J Hand Ther 21:377-85. 2008
    ..Twenty-one healthy subjects (12 female) produced maximal ab-/adduction (AbAd) efforts against a stationary apparatus equipped with four independent multiaxis force transducers...
  85. doi Association of the preoperative photoreceptor layer defect as assessed by optical coherence tomography with the functional outcome after macular hole closure: a long follow-up study
    Vlassis G Grigoropoulos
    2nd Department of Ophthalmology, Henry Dunant Hospital, Athens, Greece
    Ophthalmologica 225:47-54. 2011
    ..to evaluate the correlation between the extent of the inner/outer segment (IS/OS) defect preoperatively and improvement in postoperative best-corrected visual acuity (BCVA) associated with IS/OS line restoration...
  86. doi Role of SLAM in NKT cell development revealed by transgenic complementation in NOD mice
    Margaret A Jordan
    Comparative Genomics Centre, James Cook University, Townsville, Queensland 4811, Australia
    J Immunol 186:3953-65. 2011
    ..isoform of the C57BL/6 allele of Slamf1 was transgenically expressed on CD4(+)CD8(+) thymocytes under control of an hCD2 minigene. NOD.Nkrp1b...
  87. pmc The effect of combination therapy with rituximab and intravenous immunoglobulin on the progression of chronic antibody mediated rejection in renal transplant recipients
    Gun Hee An
    Division of Nephrology, Department of Internal Medicine, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    J Immunol Res 2014:828732. 2014
    The treatment for chronic active antibody-mediated rejection (CAMR) remains controversial. We investigated the efficacy of rituximab (RTX) and intravenous immunoglobulin (IVIg) for CAMR...
  88. doi Clinical outcome in patients with chronic antibody-mediated rejection treated with and without rituximab and intravenous immunoglobulin combination therapy
    Byung Ha Chung
    Transplant Research Center, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Division of Nephrology, Department of Internal Medicine, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Transpl Immunol 31:140-4. 2014
    ..IVIg) combination therapy (RIT) is effective in treating patients with chronic active antibody-mediated rejection (CAMR), and the proteinuria level can determine the response to RIT...
  89. ncbi Treatment of visceral malperfusion in acute type B aortic dissection by percutaneous endovascular fenestration using a stent, with additional stenting of the true lumen
    Hideki Miyachi
    Division of Intensive and Cardiovascular Care Unit, Nippon Medical School Hospital
    J Nippon Med Sch 81:340-5. 2014
    Patients with acute type B aortic dissection (ABAD) are often treated medically. However, ABAD is a potentially serious emergency if complicated by acute organ ischemia...
  90. doi Stented elephant trunk procedure with left subclavian artery transposition for acute type B dissection with distal arch involvement
    Jun Ming Zhu
    Beijing Aortic Disease Center, Beijing Institute of Heart, Lung and Blood Vessel Diseases and Beijing Anzhen Hospital, Capital Medical University, Beijing, China
    J Thorac Cardiovasc Surg 150:1160-5. 2015
    ..after thoracic endovascular aortic repair, is appealing treatment for complicated acute type B dissection (ABAD) with aortic arch involvement (AAI) because of reduced surgical trauma...
  91. doi Deciphering the role of TRIB1 in regulatory T-cells
    Richard Danger
    Institut National de la Santé et de la Recherche Médicale INSERM U1064 and Research Institute on Transplantation, Urology and Nephrology ITUN, 30 Boulevard Jean Monnet, 44093 Nantes Cedex 01, France
    Biochem Soc Trans 43:1075-8. 2015
    ..reported to be overexpressed in the blood of renal transplanted patients with chronic antibody-mediated rejection (CAMR), altogether, these results suggest TRIB1 could be linked to the decrease proportion of Tregs in patients ..
  92. doi Contemporary Management of Acute Type B Dissection
    A J Scott
    Department of Surgery and Cancer, Imperial College London, St Mary s Hospital, London, UK Imperial Vascular Unit, Imperial College Healthcare NHS Trust, St Mary s Hospital, UK
    Eur J Vasc Endovasc Surg 51:452-9. 2016
    ..In this review a clinical vignette to present a practical perspective on the contemporary management of acute type B dissection (ABAD) in a specialist vascular centre with particular focus on areas of debate is used.
  93. pmc High substrate specificity of ipsdienol dehydrogenase (IDOLDH), a short-chain dehydrogenase from Ips pini bark beetles
    Rubi Figueroa-Teran
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Reno, NV 89557, USA
    J Biochem 160:141-51. 2016
    ..structure: human L-3-hydroxyacyl-CoA dehydrogenase type II/ amyloid-β binding alcohol dehydrogenase (hHADH II/ABAD), and conducted functional assays of recombinant IDOLDH to determine substrate and product ranges and structural ..
  94. doi Mercury Release to Aquatic Environments from Anthropogenic Sources in China from 2001 to 2012
    Maodian Liu
    Ministry of Education Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China
    Environ Sci Technol 50:8169-77. 2016
    Based on an analysis of measured data and distribution factors, we developed the China Aquatic Mercury Release (CAMR) model, which we used to calculate an inventory of mercury (Hg) that was released to aquatic environments from primary ..
  95. doi Negative regulation of HLA-DR expression on endothelial cells by anti-blood group A/B antibody ligation and mTOR inhibition
    Kenta Iwasaki
    Department of Kidney Disease and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan Electronic address
    Transpl Immunol . 2016
    ..antibody (DSA), particularly against HLA class II, is a major cause of chronic antibody-mediated rejection (CAMR) after transplantation, although ABO-incompatible kidney transplantation has recently demonstrated favorable graft ..
  96. ncbi Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism
    J J Barycki
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis 55455, USA
    Biochemistry 38:5786-98. 1999
    Human heart short chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) catalyzes the oxidation of the hydroxyl group of L-3-hydroxyacyl-CoA to a keto group, concomitant with the reduction of NAD+ to NADH, as part of the beta-oxidation pathway...
  97. ncbi Evidence for fatty acid oxidation in human placenta, and the relationship of fatty acid oxidation enzyme activities with gestational age
    D Rakheja
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Placenta 23:447-50. 2002
    ..metabolism, long chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) and short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), are active in the normal human placenta...
  98. ncbi 3-Hydroxy-2-methylbutyryl-CoA dehydrogenase deficiency
    V R Sutton
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    J Inherit Metab Dis 26:69-71. 2003
    ..Urine organic acid analysis revealed 3-hydroxy-2-methylbutyric acid and tiglyglycine; 3-ketothiolase enzyme activity was normal and he was subsequently found to have 3-hydroxy-2-methylbutyryl-CoA dehydrogenase deficiency...
  99. ncbi Type 10 17beta-hydroxysteroid dehydrogenase catalyzing the oxidation of steroid modulators of gamma-aminobutyric acid type A receptors
    Xue Ying He
    Department of Neuropharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Mol Cell Endocrinol 229:111-7. 2005
    ..Immunoreactivity against 17beta-HSD10 was found in a number of neuronal populations. Taken together, evidence suggests that 17beta-HSD10 is the brain enzyme capable of catalyzing the oxidation of steroid modulators of GABA(A) receptors...
  100. ncbi [Theoretical basis in a sample of research projects carried out at the National School of Public Health, University of Antioquia, 1965-2004]
    Gustavo Cabrera Arana
    Facultad Nacional de Salud Pública de la Universidad de Antioquia
    Rev Salud Publica (Bogota) 7:99-111. 2005
    ..the theoretical basis used in the studies carried out by students and lecturers of the undergraduate and postgraduate programs of the National School of Public Health "Hector Abad Gómez" of the University of Antioquia from 1965 to 2004.
  101. ncbi [Inhibition of neuronal death by promoting degradation of intracellular amyloid beta-protein]
    Yasumasa Ohyagi
    Department School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:57-62. 2007
    ..Moreover, intraneuronal Ap is reported to induce mitochondrial dysfunction via binding ABAD, synaptic pathology, and inhibition of proteasome...

Research Grants17

  1. NMR STUDIES OF PROTEIN TARGET INTERACTIONS
    Gerhard Wagner; Fiscal Year: 2002
    ..T antigen that interact with retinoblastoma protein and Hsc70; and the interaction of the T-cell surface proteins hCD2 and HCD58...
  2. Cellular Cofactors, Neuronal Stress & Rescue, Aging & Alzheimer Disease
    Shi Du Yan; Fiscal Year: 2010
    ..The central theme of our Program Project is that specific, cell associated cofactors, RAGE (Receptor for AGEs) and ABAD (A ?binding alcohol dehydrogenase) are critical for concentrating the effects of low levels of A, relevant to early ..
  3. Changchun Xiao; Fiscal Year: 2014
    ..and autoimmune disease, and died prematurely, when this transgene was turned on in both B and T lymphocytes using hCD2-iCre...
  4. CHARLES ALFRED STANLEY; Fiscal Year: 2016
    ..used to examine potential candidate genes, including the novel gene on 10q that will be identified in Aim 1, HADH/SCHAD, SLC16A1/MCT-1, TCF1/HNF1, TCF4/HNF4, SIR2L4/SIRT4, and others...
  5. Myra L Muramoto; Fiscal Year: 2014
    ..chiropractors, and massage therapists (CAM practitioners) as part of the current NCI-funded CAM Reach Project (CAMR)...
  6. MITOCHONDRIAL SHORT CHAIN 3-OH-ACYL-COA DEHYDROGENASES
    Arnold Strauss; Fiscal Year: 2003
    ..This proposal focuses on two enzymes catalyzing the third step, the short chain 3-hydroxy-acyl-CoA dehydrogenases (SCHAD)...
  7. STRUCTURAL STUDIES OF LIPID/PROTEIN SYSTEMS
    Leonard Banaszak; Fiscal Year: 2002
    ..beta-ketoacyl CoA reaction, humans have two different enzymes: one for short chain L-3-hydroxyacyl CoA substrates (SCHAD) and one for long chain metabolites (LCHAD). Preliminary x-ray data have identified the coenzyme site of SCHAD...
  8. The Role of RAGE and EAE
    Shi Du Yan; Fiscal Year: 2005
    ....
  9. ERAB, A BETA, NEUROTOXICITY AND ALZHEIMERS DISEASE
    Shi Du Yan; Fiscal Year: 2003
    ..We have identified a novel endoplasmic reticulum-associated Abeta binding protein termed ERAB which has properties of a b-hydroxyacyl-Coenzyme A dehydrogenase/short-chain alcohol dehydrogenase...
  10. International Medical Conference of Congenital Hyperinsulinism
    Charles Stanley; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  11. PLACENTAL CARNITINE: ROLE IN FETAL DEVELOPMENT
    Prem Shekhawat; Fiscal Year: 2008
    ..abstract_text> ..
  12. ISLET DYSREGULATION IN INFANTS
    Charles Stanley; Fiscal Year: 2008
    ..The results of this research will provide essential information for improving the diagnosis and treatment of HI children and for understanding the basis of insulin regulation in normal humans. ..
  13. Ped Endocrine Career Development in Diabetes Research
    Charles Stanley; Fiscal Year: 2007
    ..The Program is strongly supported by access to a superb range of institutional resources, including the CHOP GCRC and the UPenn DERC. Request is made for 2 Appointee slots in this Program each year. ..
  14. Peer Support--Congestive Heart Failure Self-Management
    MARY ELLEN HEISLER; Fiscal Year: 2009
    ..If found effective, this approach could be used to improve health outcomes among patients with other chronic conditions, such as depression, chronic pain, or diabetes. ..
  15. Clinical Phenotype of Imprinted Genes of Chromosome 14
    Vernon Sutton; Fiscal Year: 2005
    ..This phenotype delineation will lay the foundation for understanding the effects and pathogenesis of imprinted genes on chromosome 14. ..
  16. MOLECULAR BASIS OF A NEW FORM OF HYPERINSULINISM
    CHARLES ALFRED STANLEY; Fiscal Year: 2010
    ..mutations of the mitochondrial fatty acid -oxidation enzyme, short-chain 3-hydroxy acyl-CoA dehydrogenase (SCHAD)...