HSD17B1

Summary

Gene Symbol: HSD17B1
Description: hydroxysteroid 17-beta dehydrogenase 1
Alias: 17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, SDR28C1, estradiol 17-beta-dehydrogenase 1, 17-beta-HSD 1, 17-beta-hydroxysteroid dehydrogenase type 1, 20 alpha-hydroxysteroid dehydrogenase, placental 17-beta-hydroxysteroid dehydrogenase, short chain dehydrogenase/reductase family 28C member 1, short chain dehydrogenase/reductase family 28CE, member 1
Species: human

Top Publications

  1. ncbi A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity
    Wei Qiu
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec, G1V 4G2, Canada
    FASEB J 16:1829-31. 2002
  2. doi Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy
    Mausumi Mazumdar
    Laboratory of Molecular Endocrinology and Oncology, CHUL Research Center Centre Hospitalier de Université Laval, CHUQ and Laval University, Quebec, Canada, G1V 4G2
    Biochem J 424:357-66. 2009
  3. ncbi Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes
    V Luu-The
    Medical Research Council Group in Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    Mol Endocrinol 4:268-75. 1990
  4. ncbi Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta
    V Luu The
    Department of Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    Mol Endocrinol 3:1301-9. 1989
  5. ncbi Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA
    H Peltoketo
    Department of Clinical Chemistry, University of Oulu, Finland
    FEBS Lett 239:73-7. 1988
  6. ncbi Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution
    D Ghosh
    Hauptman Woodward Medical Research Institute, Inc, Buffalo, NY 14203, USA
    Structure 3:503-13. 1995
  7. ncbi Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol
    A Azzi
    Nat Struct Biol 3:665-8. 1996
  8. ncbi HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Int J Cancer 104:450-7. 2003
  9. ncbi HSD17B1 gene polymorphisms and risk of endometrial and breast cancer
    Veronica Wendy Setiawan
    Department of Epidemiology, Harvard School of Public Health and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:213-9. 2004
  10. ncbi Associations among mammographic density, circulating sex hormones, and polymorphisms in sex hormone metabolism genes in postmenopausal women
    Ruth Warren
    Department of Radiology, University of Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:1502-8. 2006

Scientific Experts

Detail Information

Publications158 found, 100 shown here

  1. ncbi A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity
    Wei Qiu
    Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL and Laval University, Quebec, G1V 4G2, Canada
    FASEB J 16:1829-31. 2002
    ..These results confirm our initial strategy of combining studies of structural biology and enzyme mechanism in the inhibitor design, which may be applied to other steroidogenic enzymes involved in human diseases...
  2. doi Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy
    Mausumi Mazumdar
    Laboratory of Molecular Endocrinology and Oncology, CHUL Research Center Centre Hospitalier de Université Laval, CHUQ and Laval University, Quebec, Canada, G1V 4G2
    Biochem J 424:357-66. 2009
    ..Such inhibitors that block oestrogen synthesis to suppress the sulfatase pathway producing oestradiol can be used in adjuvant therapies with oestrogen receptor blockade, opening a new orientation of breast cancer treatment...
  3. ncbi Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes
    V Luu-The
    Medical Research Council Group in Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    Mol Endocrinol 4:268-75. 1990
    ..These new findings provide the basis for a better understanding of the molecular mechanisms involved in 17 beta-HSD deficiency and peripheral sex steroid metabolism...
  4. ncbi Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta
    V Luu The
    Department of Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    Mol Endocrinol 3:1301-9. 1989
    Human placenta estradiol 17 beta-dehydrogenase (E2DH) cDNA clones were isolated from a lambda gt11 expression library by screening with 33 mer synthetic oligonucleotides derived from the amino acid sequence of the catalytic site of E2DH ..
  5. ncbi Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA
    H Peltoketo
    Department of Clinical Chemistry, University of Oulu, Finland
    FEBS Lett 239:73-7. 1988
    ..The deduced amino acid sequence also contained two peptides previously characterized from the proposed catalytic area of placental 17-HSD...
  6. ncbi Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution
    D Ghosh
    Hauptman Woodward Medical Research Institute, Inc, Buffalo, NY 14203, USA
    Structure 3:503-13. 1995
    ..The amino acid sequence of 17 beta-HSD also differs from that of bacterial 3 alpha,20 beta-HSD by two insertions (of 11 and 14 residues) and 52 additional residues at the C terminus...
  7. ncbi Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol
    A Azzi
    Nat Struct Biol 3:665-8. 1996
  8. ncbi HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Int J Cancer 104:450-7. 2003
    ..Study Cohort, the relationships between polymorphisms in 2 genes involved in estrogen metabolism, CYP17 and HSD17B1, and the risk of breast cancer...
  9. ncbi HSD17B1 gene polymorphisms and risk of endometrial and breast cancer
    Veronica Wendy Setiawan
    Department of Epidemiology, Harvard School of Public Health and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:213-9. 2004
    Estrogen exposure influences breast and endometrial cancer risk. The HSD17B1 gene produces an enzyme that catalyzes the conversion of estrone to estradiol...
  10. ncbi Associations among mammographic density, circulating sex hormones, and polymorphisms in sex hormone metabolism genes in postmenopausal women
    Ruth Warren
    Department of Radiology, University of Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:1502-8. 2006
    ..SHBG), androstenedione, 17-OH-progesterone, estrone, and estrone sulfate] and 15 SNPs in the CYP17, CYP19, EDH17B2, SHBG, COMT, and CYP1B1 genes were studied...
  11. ncbi Proliferative responses to altered 17beta-hydroxysteroid dehydrogenase (17HSD) type 2 expression in human breast cancer cells are dependent on endogenous expression of 17HSD type 1 and the oestradiol receptors
    A Jansson
    Department of Biomedicine and Surgery, Division of Oncology, Linkoping University, S 581 85 Linkoping, Sweden
    Endocr Relat Cancer 13:875-84. 2006
    ..Expression of 17HSD type 1 seems to be dominant to 17HSD type 2. Therefore, it may be important to investigate a ratio between 17HSD type 1 and 17HSD type 2...
  12. ncbi Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Epidemiol 165:235-45. 2007
    ..P-450 genes CYP11A1 (-528[TTTTA]n) or CYP17A1 (-34T/C) or the 17beta-hydroxysteroid dehydrogenase 1 gene HSD17B1 (Ser312Gly) and levels of progesterone, androgens, or estrogens...
  13. ncbi Amplification of HSD17B1 has prognostic significance in postmenopausal breast cancer
    Cecilia Gunnarsson
    Department of Pathology Cytology and Genetics, Division of Genetics, Linkoping University Hospital, Linkoping, Sweden
    Breast Cancer Res Treat 108:35-41. 2008
    ..The gene coding for 17beta-HSD type 1 (HSD17B1) is located at 17q12-21...
  14. doi Integrated view on 17beta-hydroxysteroid dehydrogenases
    Gabriele Moeller
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany
    Mol Cell Endocrinol 301:7-19. 2009
    ..Strategies on deciphering the physiological role of 17beta-HSDs and the genetic predisposition for associated diseases will be presented...
  15. doi Ratio of 17HSD1 to 17HSD2 protein expression predicts the outcome of tamoxifen treatment in postmenopausal breast cancer patients
    Agneta Jansson
    Department of Clinical and Experimental Medicine, Division of Oncology, Linkoping University, Linkoping, Sweden
    Clin Cancer Res 15:3610-6. 2009
    ..The aim of this study was to investigate the prognostic and tamoxifen predictive values of 17HSD1 and 17HSD2 expression...
  16. doi Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients
    Niramol Chanplakorn
    Department of Pathology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    Breast Cancer Res Treat 120:639-48. 2010
    ..This increment may represent the compensatory response of breast carcinoma tissues to estrogen depletion...
  17. doi 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production
    Juliette A Aka
    Research Center of the Laval University Hospital Center CHUQ CHUL and Laval University, Quebec, Canada
    Mol Endocrinol 24:832-45. 2010
    ..These results strongly support the rationale for inhibiting 17beta-HSD1 in breast cancer therapy to eliminate estrogen activation via the sulfatase pathway while avoiding the deprivation of DHT...
  18. pmc The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells
    Chen Yan Zhang
    Laboratory of Molecular Endocrinology and Oncology, Centre Hospitalier de Université Laval Research Center CHUL, CHUQ and Laval University, Quebec City, Quebec, Canada
    PLoS ONE 7:e29835. 2012
    ..Moreover, kinetic studies were carried out in intact cells as a new approach, using HEK-293 cells over-expressing type 1 and T47D breast cancer cells...
  19. pmc Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells
    Daniel P Sherbet
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    Endocrinology 150:4154-62. 2009
    ..These findings suggest that additional structural features, beyond the lack of a specific arginine residue, disfavor NADPH binding and thus support E2 oxidation by 17betaHSD2 in intact cells...
  20. doi Transforming growth factor-beta1 inhibits luteinization and promotes apoptosis in bovine granulosa cells
    Xiaofeng Zheng
    Faculte de Medecine Veterinaire, Centre de Recherche en Reproduction Animale CRRA, Universite de Montreal, Quebec, Canada
    Reproduction 137:969-77. 2009
    ..and addition of TGFB1 for 6 days partially reversed this decline and stimulated E(2) biosynthesis, CYP19A1 and HSD17B1 mRNA levels and CYP19A1 activity (P<0.05)...
  21. ncbi DNA microarray-based analysis of single nucleotide polymorphisms may be useful for assessing the risks and benefits of hormone therapy
    Clemens B Tempfer
    Department of Obstetrics and Gynecology, University of Freiburg Medical School, Freiburg, Germany
    Fertil Steril 82:132-7. 2004
    ....
  22. ncbi Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer
    Julie M Cunningham
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:969-78. 2007
    ..HSD3B1, HSD3B2, HSD17B2, CYP17, SRD5A2, AKR1C3, UGT2B15, AR, SHBG, and KLK3 from the androgen pathway and CYP19, HSD17B1, CYP1A1, CYP1A2, CYP1B1, COMT, GSTP1, GSTT1, GSTM1, NQO1, ESR1, and ESR2 from the estrogen pathway...
  23. doi Activins regulate 17beta-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells
    Beata Bak
    Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    J Endocrinol 201:89-104. 2009
    ..identified the gene encoding the steroidogenic enzyme, 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1; Hsd17b1), as an activin-responsive gene in immortalized gonadotrope cells, LbetaT2...
  24. doi Polymorphism of the pig 17beta-hydroxysteroid dehydrogenase type1 (HSD17B1) gene and its association with reproductive traits
    L Q Liu
    Key Laboratory of Pig Genetics and Breeding of Ministry of Agriculture and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, PR China
    Anim Reprod Sci 114:318-23. 2009
    17beta-Hydroxysteroid dehydrogenase type 1 (HSD17B1) is a key enzyme of 17beta-estradiol biosynthesis, which might play an important role in follicular development of the ovary...
  25. ncbi Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta
    John F Couse
    Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, MD B3 02, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Mol Endocrinol 17:1039-53. 2003
    ..e. Star, Cyp11a, Cyp17, Cyp19, Hsd3b1, and Hsd17b1. These data were corroborated by assessing plasma levels of the respective peptide and steroid hormones...
  26. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
    ..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
  27. doi A mouse tool for conditional mutagenesis in ovarian granulosa cells
    Beatrice Grabner
    Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria
    Genesis 48:612-7. 2010
    ..Artificial Chromosome (BAC) containing the regulatory elements of the hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1) gene...
  28. ncbi Characterization of rat 17 beta-hydroxysteroid dehydrogenase type 1 gene and mRNA transcripts
    L A Akinola
    Biocenter Oulu, WHO Collaborating Center for Research in Human Reproduction, Finland
    Gene 208:229-38. 1998
    ..Sequence comparison of the first 200 bp upstream of the cap site showed 72% identity between the human and rat HSD17B1 genes, including a conserved GC-rich area...
  29. ncbi Ten polymorphisms of estrogen-metabolizing genes and a family history of colon cancer--an association study of multiple gene-gene interactions
    Ambros Huber
    Department of Gynecologic Endocrinology and Infertility Treatment, Medical University of Vienna, Vienna, Austria
    J Soc Gynecol Investig 12:e51-4. 2005
    ..microarrays: catechol-O-methyltransferase (COMT) Val158Met G-->A, 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17) vlV A-->C, cytochrome P-450 (CYP) 17 A2 allele T-->C, CYP1A1 MspI RFLP T-->C, CYP1A1 Ile462Val A-->G, ..
  30. ncbi Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines
    Michela Biancolella
    Department of Biopathology and Diagnostic Imaging, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy
    Invest New Drugs 25:491-7. 2007
    ..Overexpressed genes included genes encoding for proteins involved in biosynthesis and metabolism of androgen (HSD17B1;HSD17B3;CYP11B2), androgen receptor and androgen receptor co-regulators (AR;CCND1), and signal transduction(ERBB2;..
  31. doi Private inherited microdeletion/microduplications: implications in clinical practice
    Maria Antonietta Mencarelli
    Medical Genetics, Molecular Biology Department, University of Siena, Viale Bracci 2, 53100 Siena, Italy
    Eur J Med Genet 51:409-16. 2008
    ..presents sex reversal, Peters' anomaly and renal cysts and the duplication is located 4Mb away from the HSD17B1 gene, coding a key enzyme of testosterone biosynthesis...
  32. doi BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms
    Anna Jakubowska
    Pomeranian Medical University, Szczecin, Poland
    Breast Cancer Res Treat 119:201-11. 2010
    ..Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB ..
  33. ncbi Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21
    S Osborne-Lawrence
    McDermott Center for Human Growth and Development, Department of Pediatrics, Dallas, Texas 75235 8591, USA
    Genomics 25:248-55. 1995
    ..DNA sequence analyses revealed that 4 of these cDNAs were derived from known genes (EDH17B2, glucose-6-phosphatase, IAI...
  34. ncbi Expression of types 1, 2, and 3 17 beta-hydroxysteroid dehydrogenase in subcutaneous abdominal and intra-abdominal adipose tissue of women
    A M Corbould
    Department of Medicine, Flinders University, Bedford Park, Australia
    J Clin Endocrinol Metab 83:187-94. 1998
    ..The association of visceral obesity with the development of insulin resistance and dyslipidaemia raises the question of the role of steroid production in adipose tissue in the pathogenesis of these disorders...
  35. pmc Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+
    M W Sawicki
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 96:840-5. 1999
    ..One possible outcome of estrogen replacement therapy in vivo could be reduction of E2 levels in breast tissues and hence the reduced risk of estrogen-dependent breast cancer...
  36. ncbi The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action
    Minna Heikkilä
    Biocenter Oulu, University of Oulu, Aapistie 5A, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    Endocrinology 146:4016-23. 2005
    ..synthesis of testosterone in the mouse is induced in the Wnt-4-deficient ovary, including Cyp11a, Cyp17, Hsd3b1, Hsd17b1, and Hsd17b3...
  37. pmc Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis
    L Aghajanova
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    Biol Reprod 80:105-14. 2009
    ..E2) and P4 biosynthetic and metabolizing enzymes is disturbed (decreased HSD3B1 and HSD17B2, and increased HSD17B1 and aromatase), with the equilibrium being shifted towards an E2-enriched milieu...
  38. doi Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells
    Patricia Kruchten
    8 2 Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrucken, Germany
    J Steroid Biochem Mol Biol 114:200-6. 2009
    ..In conclusion, our findings strongly support suitability of non-steroidal 17betaHSD1-inhibitors for the treatment of estrogen dependent diseases...
  39. doi Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis
    Merit Lamp
    Department of Obstetrics and Gynaecology, University of Tartu, Tartu, Estonia
    Gynecol Endocrinol 27:425-33. 2011
    ..To investigate whether polymorphisms in genes involved in biosynthesis and signalling of sex steroids influence susceptibility to endometriosis and to infertility associated with it...
  40. doi Effects of progestins on local estradiol biosynthesis and action in the Z-12 endometriotic epithelial cell line
    Nataša Beranič
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    J Steroid Biochem Mol Biol 132:303-10. 2012
    ..results show that application of medroxyprogestrone acetate, dydrogesterone and dienogest significantly decreases HSD17B1 and CYP19A1 expression and significantly increases HSD17B2 expression...
  41. doi Confirmation of the reduction of hormone replacement therapy-related breast cancer risk for carriers of the HSD17B1_937_G variant
    Ofure Obazee
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376, Stuttgart, Germany
    Breast Cancer Res Treat 138:543-8. 2013
    17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) plays an important role in the biosynthesis of 17β-estradiol...
  42. doi Testosterone treatment increases androgen receptor and aromatase gene expression in myotubes from patients with PCOS and controls, but does not induce insulin resistance
    Mette Brandt Eriksen
    Department of Endocrinology, Odense University Hospital, Odense, Denmark Department of Clinical Research, University of Southern Denmark, Odense, Denmark Department of Clinical Pathology, Odense University Hospital, Odense, Denmark University Library of Southern Denmark, University of Southern Denmark, Odense, Denmark Electronic address
    Biochem Biophys Res Commun 451:622-6. 2014
    ..gene expression levels of hormone receptors and enzymes involved in the synthesis and conversion of testosterone (HSD17B1, HSD17B2, CYP19A1, SRD5A1-2, AR, ER-α, HSD17B6 and AKR1-3) in myotubes from ten patients with PCOS and ten ..
  43. doi Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis
    Qing Wen
    State Key Laboratory of Reproduction Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China University of Chinese Academy of Sciences, Beijing, China and
    Am J Physiol Endocrinol Metab 307:E1131-43. 2014
    ..Deletion of Wt1 gene also perturbed the expression of steroidogenic enzymes Star, P450c17, Hsd3b6, Hsd3b1, Hsd17b1, and Hsd17b3...
  44. doi 203 pi3-k pathway is one of the key regulators of steroidogenesis of cumulus cells of bovine cumulus-oocyte complexes maturated in defined medium in the presence of fsh
    D Kaiser de Souza
    University of Brasilia, Brasilia, DF, Brazil
    Reprod Fertil Dev 27:192. 2014
    ..from 20 COC were isolated by centrifugation to determine the gene expression of LHR, FSHR, CYP11A1, CYP19A1, and HSD17B1 by PCR real time. Cumulus cells of immature COC were also collected and analysed as the calibrator group...
  45. doi Increased 17ß-hydroxysteroid dehydrogenase type 1 levels in primary cervical cancer
    Agata Tomaszewska
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland The Centre for Orthodontic Mini implants of the Chair and Clinic of Maxillofacial Orthopedics and Orthodontics, Poznan University of Medical Sciences, Poznan, Poland
    Biomed Pharmacother 72:179-83. 2015
    ..The 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) is the enzyme involved in the transformation of estrone (E1) into E2...
  46. ncbi Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21
    J M Rommens
    Department of Genetics, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Genomics 28:530-42. 1995
    ..of genes with restricted patterns of expression were also obtained, including the previously characterized HSD17B1. One new gene, for which a full-length cDNA was isolated, was found to have an interesting tissue-specific ..
  47. ncbi Genetic analysis of the BRCA1 region in a large breast/ovarian family: refinement of the minimal region containing BRCA1
    D P Kelsell
    Imperial Cancer Reseach Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, UK
    Hum Mol Genet 2:1823-8. 1993
    ..We have sequenced the 17 beta-oestradiol dehydrogenase genes (EDH17B1 and EDH17B2) which have been suggested as candidate genes for BRCA1 in four members of this family...
  48. ncbi Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21
    T Normand
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Hum Mol Genet 2:479-83. 1993
    ..These polymorphisms in the 17 beta-HSD II gene provide markers that can be used for the genetic mapping of this locus, and may be used to establish whether 17 beta-HSD II is a candidate gene for hereditary breast-ovarian cancer...
  49. ncbi Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5
    S X Lin
    Molecular Endocrinology Research Center at Laval University Hospital Research Center CHUL, CHUQ, Laval University, Que, Canada G1V 4G2
    Mol Cell Endocrinol 248:38-46. 2006
    ..The multi-specificity contributes significantly to steroid metabolism in peripheral tissues, due to the high levels of 17beta-HSD5 mRNA in both breast and prostate tissues...
  50. doi Role of transforming growth factor-beta1 in gene expression and activity of estradiol and progesterone-generating enzymes in FSH-stimulated bovine granulosa cells
    Xiaofeng Zheng
    Faculte de Medecine Veterinaire, Centre de Recherche en Reproduction Animale CRRA, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Reproduction 136:447-57. 2008
    ..of E(2)-related enzymes cytochrome P450 aromatase (CYP19A1) and 17beta-hydroxysteroid dehydrogenase type 1 (HSD17B1), but not HSD17B7...
  51. pmc Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss
    Jonathan Q Purnell
    Oregon Health and Science Univ, Div of Endocrinology, Diabetes, and Clinical Nutrition, Center for the Study of Weight Regulation, L481, 3181 SW Sam Jackson Park, Portland, OR 97239, USA
    Am J Physiol Endocrinol Metab 296:E351-7. 2009
    ....
  52. doi Role of BRCA1, HSD17B1 and HSD17B2 methylation in breast cancer tissue
    V Bhavani
    Department of Genetics, Vasavi Hospital and Research Centre, Khairtabad, Hyderabad, India
    Cancer Biomark 5:207-13. 2009
    ..cancer (BC): The breast cancer susceptibility gene 1 (BRCA1), 17 beta hydroxy steroid dehydrogenase type 1 (HSD17B1) and type 2 (HSD17B2)...
  53. doi Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes
    Alberto Ferlin
    Section of Clinical Pathology and Centre for Male Gamete Cryopreservation, Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    Endocr Relat Cancer 17:17-25. 2010
    ..and 218 controls: ESR (ESR1 and ESR2); CYP19A1 (aromatase); 17beta-hydroxysteroid dehydrogenase types 1 and 4 (HSD17B1 and HSD17B4) dehydrogenases that convert potent androgens and estrogens to weak hormones; cytochrome P450 ..
  54. pmc Novel hydroxysteroid (17beta) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic mice
    Taija Saloniemi
    Department of Physiology, University of Turku, and the Department of Obstetrics and Gynecology, Turku University Central Hospital, Kiinamyllynkatu 10, FIN 20014 Turku, Finland
    Am J Pathol 176:1443-51. 2010
    ..Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) is an enzyme that catalyzes with high efficiency the conversion of weakly active estrone into highly potent ..
  55. doi Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Nutr Cancer 62:466-75. 2010
    ..06-0.77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk...
  56. doi Type 10 17β-hydroxysteroid dehydrogenase expression is regulated by C/EBPβ in HepG2 cells
    Mirja Rotinen
    Department of Health Sciences, Universidad Publica de Navarra, Avda Barañain, 31008 Pamplona, Spain
    J Steroid Biochem Mol Biol 122:164-71. 2010
    ..Here, we analyze the 5'-flanking region of 14 promoters (HSD17B1-14) looking for CCAAT boxes and binding sites for CCAAT enhancer binding factors (C/EBPs)...
  57. pmc Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women
    Susan E Olivo-Marston
    Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 31:1778-86. 2010
    ..Understanding the genetic control of estrogen biosynthesis and response in lung cancer could lead to improved prognosis and therapy...
  58. doi Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk
    J Sainz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 18:265-76. 2011
    ..in steroid hormone signaling (ESR1, ESR2, PGR, NR1I2, and SHBG), phase I- and II-metabolizing enzyme (COMT, HSD17B1, CYP1A1, CYP17A1, CYP1A2, CYP1B1, CYP2C9, CYP3A4, CYP2C19, and GSTP1), and hormone transporter (ABCB1) genes with ..
  59. doi Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes
    Anja Rudolph
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Endocr Relat Cancer 18:371-84. 2011
    ..genes related to hormone metabolism (COMT, CYP1A1, CYP1A2, CYP1B1, CYP2C9, CYP2C19, CYP3A4, CYP17A1, GSTP, and HSD17B1), transport (ABCB1), and signaling (ESR1, ESR2, SHBG, PGR, and NR1I2)...
  60. doi Butyrate induces expression of 17β-hydroxysteroid dehydrogenase type 1 in HT29 and SW707 colorectal cancer cells
    Agnieszka Anna Rawłuszko
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland
    DNA Cell Biol 30:661-9. 2011
    ..In peripheral tissue, E2 can be produced locally by 17β-hydroxysteroid dehydrogenase 1 (HSD17B1) estrone (E1) reduction...
  61. doi Hydroxysteroid (17-β) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia
    Osamu Ishibashi
    Department of Molecular Medicine and Anatomy, Nippon Medical School, 1 1 5 Sendagi, Tokyo 113 8602, Japan
    Hypertension 59:265-73. 2012
    ..5 of which were predicted in silico to commonly target the mRNA encoding hydroxysteroid (17-β) dehydrogenase 1 (HSD17B1), a steroidogenetic enzyme expressed predominantly in the placenta...
  62. pmc 17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration
    Juliette A Aka
    Laboratory of Molecular Endocrinology and Oncology, Centre Hospitalier Universitaire de Québec Research Center CHUQ CHUL and Department of Molecular Medicine, Laval University, 2705 Boulevard Laurier, Quebec G1V 4G2, Canada
    Breast Cancer Res 14:R92. 2012
    ..Here, we demonstrate the impact of 17β-HSD1 expression on the breast cancer cell proteome and investigate its role in cell migration...
  63. doi Conversion of estrone to 17-beta-estradiol in human non-small-cell lung cancer cells in vitro
    Hanna Drzewiecka
    Poznan University of Medical Sciences, Department of Biochemistry and Molecular Biology, Poznan, Poland
    Biomed Pharmacother 66:530-4. 2012
    ..Therefore, we evaluated the transcript and protein levels of 17-beta-hydroxysteroid-dehydrogenase type 1 (HSD17B1), and the conversion of estrone (E1) to 17-beta-estradiol (E2) in human non-small cell lung cancer (NSCLC) Calu-6,..
  64. pmc Transcriptome analysis during human trophectoderm specification suggests new roles of metabolic and epigenetic genes
    Said Assou
    CHU Montpellier, Institute for Research in Biotherapy, Hopital Saint Eloi, INSERM U1040, Montpellier, France
    PLoS ONE 7:e39306. 2012
    ..MUC15), chromatin remodeling (specifically the DNA methyltransferase DNMT3L) and steroid metabolism (HSD3B1, HSD17B1 and FDX1). In day 3 human embryos 1,714 transcripts were specifically up-regulated...
  65. pmc Dioxin exposure reduces the steroidogenic capacity of mouse antral follicles mainly at the level of HSD17B1 without altering atresia
    Bethany N Karman
    Department of Comparative Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Toxicol Appl Pharmacol 264:1-12. 2012
    ..TCDD exposure for 48h increased levels of A4, without changing HSD3B1 protein, HSD17B1 protein, estrone (E1), T or E2 levels. Further, TCDD did not alter atresia ratings compared to vehicle at 48h...
  66. doi Between-female variation in house sparrow yolk testosterone concentration is negatively associated with CYP19A1 (aromatase) mRNA expression in ovarian follicles
    Jeremy R Egbert
    School of Biological Sciences, Washington State University, WA 99164 4236, United States
    Gen Comp Endocrinol 183:53-62. 2013
    ..protein (StAR), cytochrome P450-side chain cleavage enzyme (CYP11A1), 17β-hydroxysteroid dehydrogenase (HSD17B1), and aromatase (CYP19A1)...
  67. pmc Gene expression changes in adipose tissue with diet- and/or exercise-induced weight loss
    Kristin L Campbell
    National Center for Tumor Diseases NCT, Division of Preventive Oncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 460, Heidelberg 69120, Germany
    Cancer Prev Res (Phila) 6:217-31. 2013
    ..by weight change category, greater weight loss was associated a decrease in 17β-hydroxysteroid dehydrogenase-1 (HSD17B1, Ptrend < 0.01) and leptin (LEP, Ptrend < 0...
  68. doi Expression of 17β-hydroxysteroid dehydrogenase type 1 in gastric cancer
    Bartosz Adam Frycz
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 Swiecickiego St, 60 781 Poznan, Poland Electronic address
    Biomed Pharmacother 67:651-7. 2013
    ..E2) may be formed during estrone (E1) reduction to E2 by 17-β-hydroxysteroid dehydrogenase type 1 (HSD17B1)...
  69. doi Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells
    Chen Yan Zhang
    Laboratory of Molecular Endocrinology and Oncology, CHU de Quebec Research Center CHUL and Laval University, Quebec City, Quebec G1V4G2, Canada Key Laboratory for Space Bioscience and Biotechnology, Faculty of Life Sciences, Northwestern Polytechnic University, Xi an, Shaanxi, China
    J Steroid Biochem Mol Biol 150:24-34. 2015
    ..17β-HSD1 and -7 are principal reductive 17β-HSDs and major players in the viability of estrogen-dependent breast cancer cells. Combined targeting of these enzymes may be potential for molecular therapy of such cancer...
  70. doi Increased expression of 17-beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer
    Hanna Drzewiecka
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Swiecickiego 6 Street, 60 781 Poznan, Poland Electronic address
    Lung Cancer 87:107-16. 2015
    ..The 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) catalyzes the reduction of estrone (E1) to the highly potent E2...
  71. doi HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo
    Päivi Järvensivu
    Department of Physiology, University of Turku, Kiinamyllynkatu 10, FIN 20520 Turku, Finland
    Chem Biol Interact 234:126-34. 2015
    Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) belongs to a family of short-chain-dehydrogenases...
  72. pmc Variants in RBP4 and AR genes modulate age at onset in familial amyloid polyneuropathy (FAP ATTRV30M)
    Diana Santos
    UnIGENe, IBMC, Institute for Molecular and Cell Biology, and Instituto de Investigação e Inovação em Saúde i3S, Universidade do Porto, Porto, Portugal
    Eur J Hum Genet 24:756-60. 2016
    ..of APCS and RBP4 genes and to study for the first time the involvement of sex-linked genetic modifiers - AR and HSD17B1 genes - in AO variation in Portuguese families...
  73. doi Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women
    Satoyo Hosono
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan Electronic address
    Maturitas 82:394-401. 2015
    ..We examined possible associations between serum sex hormone level and polymorphisms in CYP19A1, HSD17B1, and HSD17B2. We also assessed possible interaction between these polymorphisms and current overweight.
  74. doi Differential expression of steroidogenic enzymes according to endometriosis type
    Sebastien Colette
    Universite Catholique de Louvain, Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium
    Fertil Steril 100:1642-9. 2013
    ..lesions, expression of steroidogenic enzymes involved in the activation and inactivation of estrogens: 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) and 2 (HSD17B2), estrone sulfotransferase (EST), and steroid sulfatase (STS).
  75. pmc Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation
    Tobias Klein
    Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrucken, Germany
    PLoS ONE 6:e22990. 2011
    ..Additionally, it facilitates inhibitor design and optimization by offering new information on protein-ligand interactions...
  76. pmc Decreased expression of 17β-hydroxysteroid dehydrogenase type 1 is associated with DNA hypermethylation in colorectal cancer located in the proximal colon
    Agnieszka Anna Rawłuszko
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland
    BMC Cancer 11:522. 2011
    ..sulfatase pathway from estrone (E1) sulfate followed by E1 reduction to E2 by 17-β-hydroxysteroid dehydrogenase (HSD17B1), so HSD17B1 gene expression may play an important role in the production of E2 in peripheral tissue, including ..
  77. doi Overexpression of 17β-hydroxysteroid dehydrogenase type 1 increases the exposure of endometrial cancer to 17β-estradiol
    Karlijn M C Cornel
    Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, P Debyelaan 25, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 97:E591-601. 2012
    ..The local interconversions between estrone (low activity) and 17β-estradiol (potent compound) by 17β-hydroxysteroid dehydrogenases (17β-HSDs) can lead to high 17β-estradiol generation in endometrial cancer (EC)...
  78. pmc Estrogen-related genes and their contribution to racial differences in breast cancer risk
    Kerryn W Reding
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Causes Control 23:671-81. 2012
    ..in genes related to estrogen metabolism (COMT, CYP1A1, CYP1B1, CYP17A1, CYP19A1, ESR1, GSTM1, GSTP1, GSTT1, HSD17B1, SULT1A1, and UGT1A1) contributes to breast cancer risk and/or racial differences in risk within the CARE study, ..
  79. doi Plasma level of hydroxysteroid (17-β) dehydrogenase 1 in the second trimester is an independent risk factor for predicting preeclampsia after adjusting for the effects of mean blood pressure, bilateral notching and plasma level of soluble fms-like tyrosin
    Akihide Ohkuchi
    Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan
    Hypertens Res 35:1152-8. 2012
    ..Recently, we disclosed that reducing the plasma level of hydroxysteroid (17-β) dehydrogenase 1 (HSD17B1), which is a steroidogenetic enzyme catalyzing the conversion of estrone to 17β-estradiol, is a potential ..
  80. doi Progesterone and estradiol in cat placenta--biosynthesis and tissue concentration
    Beate C Braun
    Leibniz Institute for Zoo and Wildlife Research, PF601103, 10252 Berlin, Germany
    J Steroid Biochem Mol Biol 132:295-302. 2012
    ..pregnancy stages were analyzed for mRNA expression of five steroidogenic enzymes (HSD3B1, CYP11A1, CYP17A1, HSD17B1 and CYP19A1) and for tissue concentrations of progesterone and estradiol...
  81. doi An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins
    D G Ndossi
    Norwegian School of Veterinary Science, Oslo, Norway Sokoine University of Agriculture, Morogoro, Tanzania
    Toxicol Lett 214:268-78. 2012
    ..T-2 toxin caused down-regulation of NR0B1 and NR5A1 whereas HT-2 toxin induced up-regulation of EPHX and HSD17B1 and down-regulation of CYP11A and CYP17...
  82. pmc The anti-epileptic drug valproic acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro
    Claire Glister
    School of Biological Sciences, University of Reading, Reading, Berkshire, United Kingdom
    PLoS ONE 7:e49553. 2012
    ..VPA reversed FSH-induced upregulation of CYP19A1 and HSD17B1 mRNA abundance (P<0.001)...
  83. doi The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells
    Pasi Huuskonen
    University of Eastern Finland, Faculty of Health Sciences, School of Pharmacy, FI 70211 Kuopio, Finland
    Toxicol Lett 218:200-6. 2013
    ..ABCC1, ABCC2, ABCG2, OAT4 and the mRNA expression of steroid-metabolizing enzymes CYP1A1, CYP19A1, HSD3B1 and HSD17B1, and conjugating enzyme family UGT1A were evaluated in trophoblastic JEG-3 cells...
  84. ncbi Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093
    Mol Endocrinol 3:881-4. 1989
    ..We propose that the steroid recognition site on 17 beta-OH-steroid dehydrogenase evolved from an ancestral recognition site for polyols such as ribitol and glucitol-6-phosphate...
  85. ncbi Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione
    G L Murdock
    J Biol Chem 258:11460-4. 1983
    ..It is concluded that the steroid-binding site of human placental estradiol 17 beta-dehydrogenase contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step...
  86. ncbi The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases
    S Andersson
    Department of Biochemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    J Steroid Biochem Mol Biol 53:37-9. 1995
    ..The 17 beta-HSD3 gene is mutated in male pseudohermaphrodites with the genetic disease 17 beta-HSD deficiency...
  87. ncbi Synthesis of 16-(bromoalkyl)-estradiols having inhibitory effect on human placental estradiol 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD type 1)
    M R Tremblay
    Medicinal Chemistry Division, CHUL Research Center, Quebec, Canada
    Bioorg Med Chem 3:505-23. 1995
    ..Consequently, 16 alpha-(bromopropyl)-E2, 16 alpha-(bromobutyl)-E2, and 16 beta-(bromobutyl)-E2 were the best inhibitors discussed in this paper...
  88. ncbi The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21
    P Tonin
    Department of Medicine, Montreal General Hospital, Quebec, Canada
    Hum Mol Genet 3:1679-82. 1994
    ..A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17 beta-dehydrogenase II...
  89. ncbi A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase
    M Montagna
    International Agency for Research on Cancer, Lyon, France
    Hum Genet 96:532-8. 1995
    ..Using the cDNA of the EDH17B2 gene as a probe, we screened a human genomic cosmid library...
  90. ncbi Kinetic analysis of enzymic activities: prediction of multiple forms of 17 beta-hydroxysteroid dehydrogenase
    C H Blomquist
    Department of Obstetrics and Gynecology, Ramsey Clinic St Paul Ramsey Medical Center, MN 55101, USA
    J Steroid Biochem Mol Biol 55:515-24. 1995
    ..Mouse ovary appears to contain forms of 17 beta-HSD which differ from 17 beta-HSD type 1 and type 2 in their kinetic properties...
  91. ncbi Molecular dissection of a cosmid from a gene-rich region in 17q21 and characterization of a candidate gene for alpha-N-acetylglucosaminidase with two cDNA isoforms
    Z Zhao
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mamm Genome 7:686-90. 1996
    ..Finally, our study has shown that the 46.7-kb cosmid c140c10 encompasses loci for five genes and pseudo-genes: PsiPTP4A, ufHSD, 17-HSDI, 17-HSDII, and 22A1...
  92. ncbi TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor
    M Bjerknes
    Department of Anatomy and Cell Biology, University of Toronto, Ont, Canada
    Gene 181:7-11. 1996
    ..expressed putative basic helix-loop-helix leucine-zipper (bHLH-zip) transcription factor which is located 3' to HSD17B1 (17-beta-hydroxysteroid dehydrogenase gene) at 17q21...
  93. ncbi Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase
    C Mazza
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale J P Ebel, CEA CNRS, 41, avenue des Martyrs, F 38027 Grenoble cedex, France
    J Biol Chem 273:8145-52. 1998
    ..Analysis of the catalytic properties of, and estradiol binding to, the two mutants suggests that the His221-steroid O3 hydrogen bond plays an important role in substrate specificity...
  94. ncbi Prominent sex steroid metabolism in human lymphocytes
    Z Zhou
    Department of Pediatrics, North Shore University Hospital, New York University School of Medicine, Manhasset 11030, USA
    Mol Cell Endocrinol 138:61-9. 1998
    ..both cultured and fresh peripheral lymphocytes for CYP11A, CYP17, HSD11L (11beta-hydroxysteroid dehydrogenase I), HSD17B1 (17beta-hydroxysteroid dehydrogenase type I) and SRD5A1 (5alpha-reductase I)...
  95. ncbi Hormonal carcinogenesis
    B E Henderson
    Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, MS44, PO Box 33800, Los Angeles, CA 90033 0800, USA
    Carcinogenesis 21:427-33. 2000
    ..The genes included in the breast cancer model are the 17beta-hydroxysteroid dehydrogenase 1 (HSD17B1) gene, the cytochrome P459c17alpha (CYP17) gene, the aromatase (CYP19) gene, and the estrogen receptor alpha (ER) ..
  96. ncbi Identification and characterization of 17 beta-hydroxysteroid dehydrogenases in the zebrafish, Danio rerio
    R Mindnich
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstaedter Landstr 1, Neuherberg 85764, Germany
    Mol Cell Endocrinol 215:19-30. 2004
    ..17beta-HSD type 1 (HSD17B1) catalyzes the reduction of estrone to estradiol, while type 3 (HSD17B3) performs the conversion of ..
  97. ncbi Single-nucleotide polymorphisms in the 17beta-hydroxysteroid dehydrogenase genes might predict the risk of side-effects of estramustine phosphate sodium in prostate cancer patients
    Motofumi Suzuki
    Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Urol 12:166-72. 2005
    ..We analyzed single nucleotide polymorphisms (SNP) in the 17beta-hydroxysteroid dehydrogenase (HSD17B) genes, which are involved in the metabolism of EMP, to predict the risk of EMP side-effects in prostate cancer patients...
  98. ncbi Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions
    Ambros Huber
    Department of Obstetrics and Gynecology, Medical University Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Obstet Gynecol 106:1025-31. 2005
    ..We aimed to investigate the association among 10 single nucleotide polymorphisms (SNPs) involved in the estrogen metabolism and endometriosis and to develop a multiple genetic model...
  99. pmc Genetic variation in the HSD17B1 gene and risk of prostate cancer
    Peter Kraft
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 1:e68. 2005
    ..Here we report on the results of a comprehensive study of the association between HSD17B1 and prostate cancer by the Breast and Prostate Cancer Cohort Consortium, a large collaborative study...
  100. ncbi Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type 1
    B Keller
    GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Genome Analysis Center, Ingolstaedter Landstr 1, 85764 Neuherberg, Germany
    Mol Cell Endocrinol 248:168-71. 2006
    17Beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) is a key enzyme of 17beta-estradiol biosynthesis, and in rodents is additionally involved in testosterone biosynthesis...
  101. ncbi [Genetic aspects of polycystic ovary syndrome]
    Lucjusz Jakubowski
    Department of Genetics, Polish Mother s Memorial Hospital Research Institute, 93 338 Lodz, Poland
    Endokrynol Pol 56:285-93. 2005
    ..have been tested include genes involved in steroid hormone biosynthesis and metabolism (StAR, CYP11, CYP17, CYP19 HSD17B1-3, HSD3B1-2), gonadotropin and gonadal hormones action (ACTR1, ACTR2A-B, FS, INHA, INHBA-B, INHC, SHBG, LHCGR, ..

Research Grants22

  1. Genes, Hormones and Breast Cancer Risk
    Veronica Wendy Setiawan; Fiscal Year: 2010
    ..levels, 2) characterize genetic variation of estrogen biosynthesis genes (CYP11A, CYP17, CYP19, HSD3B1, HSD3B2, HSD17B1, HSD17B2, and SHBG) using a two-pronged approach (putative functional variants and inferred haplotypes) and ..
  2. Estrogen and Progesterone-related Gene Variants and Colorectal Cancer Risk
    Shumin Zhang; Fiscal Year: 2009
    ..responsible for local estrogen concentrations and the conversion of progesterone to estrogens via androgens (HSD17B1, HSD17B2, HSD17B4, CYP19A1, and CYP17A1) and for estrogen catabolism (CYP1A1, CYP1B1, and COMT)...
  3. EPIDEMIOLOGY OF MENOPAUSE AND DEMENTIA IN DOWN SYNDROME
    Nicole Schupf; Fiscal Year: 2009
    ..We will examine 5 candidate genes: ERalpha, ERbeta, CYP17, CYP19, and HSD17B1. We will determine whether polymorphisms in the genes for ERalpha (P and X), ERbeta (G), Cyp17 (Allele A2), CYP19 ..
  4. GENES AND THE ESTROGEN EFFECT ON ENDOMETRIAL CANCER
    Giske Ursin; Fiscal Year: 2006
    ..We propose to evaluate a series of eight candidate genes (CYP17, CYP19, HSD17B1, ER, CYP1A1, CYP1B1, COMT andPR) in the estrogen biosynthesis, transactivation and metabolism pathways to ..
  5. BRCA1 AND BRCA2 IN AFRICAN-AMERICAN AND LATINO FAMILIES
    Brian Henderson; Fiscal Year: 2002
    ..of BRCA1, BRCA2, the cytochrome P450cl7alpha gene (CYP17), and the 17beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) among African-American and Latino families with a history of breast and ovarian cancer and evaluate possible ..
  6. MENOPAUSAL TRANSITION: A BIOBEHAVIORAL MODEL OF SYMPTOMS
    Ellen Mitchell; Fiscal Year: 2006
    ..of genetic polymorphisms of the estrogen receptor gene (ESR1 PvuII) and estrogen metabolic genes (CYP17, CYP19, EDH17B2, CYP1A1, CYP1b1 enzymes) on estradiol and estrone levels, age of onset of middle and late transition and ..
  7. GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS
    Brian Henderson; Fiscal Year: 2000
    ..Specifically, this proposal will investigate polymorphisms in candidate genes (NAT2, GSTM1, CYP1A1, SRD5A2, AR, EDH17B2, CYP17, and ER), that might alter metabolism of relevant endogenous or exogenous exposures and their interactions ..
  8. Genetic Susceptibility to Infection Related Cancer
    Ikuko Kato; Fiscal Year: 2005
    ..Secondary aims include to examine histopathological correlates of these polymorphisms and to determine whether selected environmental factors modify the above associations. ..
  9. Sex steroid, HPA regulation, and fat patterning
    Jonathan Purnell; Fiscal Year: 2003
    ..abstract_text> ..
  10. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  11. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  12. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  13. DIETARY AND GENETIC DETERMINANTS OF MAMMOGRAPHIC DENSITY
    Anna Wu; Fiscal Year: 2008
    ..For example, we will evaluate whether the associations between estrogen metabolizing genes (e.g., HSD17B1, CYP1B1, COMT, SULT1A1) and mammographic density are stronger among low soy consumers...
  14. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  15. Luminal Lipid Exposure, Genetics and Colon Cancer Risk
    Ikuko Kato; Fiscal Year: 2006
    ..In addition, accumulated dietary data and biological specimens will serve as an important resource for future research on other nutrient-gene interactions. ..
  16. Hypothalamic fMRI response to nutrients
    Jonathan Purnell; Fiscal Year: 2007
    ..These studies will help us to better understand why changes in the diet might lead to weight gain or loss. [unreadable] [unreadable] [unreadable]..
  17. Foward Genetic Study of Surface Coat Genes Expression in Trypanosoma Brucei
    Gwo Shu Lee; Fiscal Year: 2008
    ..The success of this study may lead to potential targets for therapeutic designs via intervention of essential processes involved in the switching of VSG gene expression. [unreadable] [unreadable] [unreadable]..
  18. TRANSCIPTION OF PROTEIN CODING GENES IN T BRUCE
    Gwo Shu Lee; Fiscal Year: 2001
    ..abstract_text> ..
  19. Structure and Regulation of Ghrelin in Obesity
    Jonathan Q Purnell; Fiscal Year: 2010
    ..Results from these studies will broaden our understanding of the brain-gut axis involved in body weight regulation by clarifying the regulation of ghrelin levels and structure in lean and obese individuals. ..
  20. Regulation of Cortisol Metabolism and Fat Patterning
    Jonathan Purnell; Fiscal Year: 2007
    ..abstract_text> ..
  21. ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER
    Sara Olson; Fiscal Year: 2005
    ..This study will provide data on genetic susceptibility in endometrial cancer in conjunction with established risk factors, as well as the first epidemiologic data on the more lethal serous and clear cell tumors. ..
  22. CORTISOL, CENTRAL OBESITY, AND INSULIN RESISTANCE
    Jonathan Purnell; Fiscal Year: 2003
    ....