hRED2

Summary

Gene Symbol: hRED2
Description: adenosine deaminase, RNA specific B2 (inactive)
Alias: ADAR3, RED2, double-stranded RNA-specific editase B2, RED2 homolog, RNA-dependent adenosine deaminase 3, RNA-editing deaminase 2, RNA-editing enzyme 2, adenosine deaminase, RNA-specific, B2 (RED1 homolog rat), adenosine deaminase, RNA-specific, B2 (RED2 homolog rat), adenosine deaminase, RNA-specific, B2 (non-functional), dsRNA adenosine deaminase B2, homolog of rat BLUE
Species: human

Top Publications

  1. ncbi Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles
    A Valenzuela
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona, Catalonia, Spain
    J Immunol 158:3721-9. 1997
  2. pmc Novel exon of mammalian ADAR2 extends open reading frame
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, United States of America
    PLoS ONE 4:e4225. 2009
  3. doi RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury
    Hitoshi Uchida
    Department of Medical Chemistry, Kansai Medical University, Osaka, Japan
    FASEB J . 2017
  4. doi Modelling C9ORF72 hexanucleotide repeat expansion in amyotrophic lateral sclerosis and frontotemporal dementia
    Alan Stepto
    Department of Neuroscience, Institute of Psychiatry, King s College London, PO Box 37, 16 De Crespigny Park, London, SE5 8AF, UK
    Acta Neuropathol 127:377-89. 2014
  5. pmc Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines
    Charlotte J Houldcroft
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom Division of Biological Anthropology, Department of Archaeology and Anthropology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 9:e108384. 2014
  6. doi Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls
    Jon Infante
    Service of Neurology, University Hospital Marqués de Valdecilla IDIVAL, University of Cantabria UC, Santander, Spain Centro de Investigación en Red de Enfermedades Neurodegenerativas CIBERNED, Instituto de Salud Carlos III, Madrid, Spain Electronic address
    Neurobiol Aging 36:1105-9. 2015
  7. pmc Diverse selective regimes shape genetic diversity at ADAR genes and at their coding targets
    Diego Forni
    a Bioinformatics Scientific Institute IRCCS E MEDEA Bosisio Parini, Italy
    RNA Biol 12:149-61. 2015
  8. pmc Case-control study of ADARB1 and ADARB2 gene variants in migraine
    Claudia F Gasparini
    Menzies Health Institute Queensland, Griffith University Gold Coast, Parklands Drive, Southport, QLD, 4222, Australia
    J Headache Pain 16:511. 2015
  9. doi Identification of SPAG9 as a novel JAK2 fusion partner gene in pediatric acute lymphoblastic leukemia with t(9;17)(p24;q21)
    Machiko Kawamura
    Department of Hematology, Saitama Cancer Center, Saitama, Japan
    Genes Chromosomes Cancer 54:401-8. 2015
  10. pmc Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing
    Jerome Nicod
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nat Genet 48:912-8. 2016

Research Grants

  1. Kazuko Nishikura; Fiscal Year: 2016
  2. Novel PDEs for Cortical Mapping and Analysis in Disease
    Paul Thompson; Fiscal Year: 2004
  3. Algorithms to Map Disease & Genetic Effects on the Brain
    Paul Thompson; Fiscal Year: 2005
  4. Computational Modeling of High-Field MR Images
    Paul M Thompson; Fiscal Year: 2010
  5. A Multidimensional Alzheimer's Disease Brain Atlas
    Paul M Thompson; Fiscal Year: 2010
  6. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
  7. Genetic Dissection of Sickle Cell Anemia Phenotypes
    Paola Sebastiani; Fiscal Year: 2006
  8. A novel approach for gene therapy
    Stefan Maas; Fiscal Year: 2008
  9. MECHANISM OF INTERFERON ACTION
    CHARLES SAMUEL; Fiscal Year: 2009
  10. MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDER
    GREGORY HANNA; Fiscal Year: 2001

Scientific Experts

  • Qingde Wang
  • Paul Thompson
  • Jon Infante
  • Stephen J Spatz
  • Marco Grados
  • CHARLES SAMUEL
  • Patricia Amara
  • J Harmer
  • Stefan Maas
  • P H Seeburg
  • O A Sergeeva
  • G Kohr
  • Jochen Meier
  • Yongfeng Jin
  • Xiangyang Kong
  • Paola Sebastiani
  • J Blanco
  • GREGORY HANNA
  • Kazuko Nishikura
  • Rudolf K Thauer
  • Felix Mahlert
  • Meike Goenrich
  • Bernhard Jaun
  • Evert C Duin
  • Jian Feng
  • Hitoshi Uchida
  • Cinzia Finazzo
  • Jennifer B Permuth
  • Jerome Nicod
  • Claudia F Gasparini
  • Machiko Kawamura
  • Diego Forni
  • Charlotte J Houldcroft
  • Alan Stepto
  • Tetsuro Hirose
  • Lyn R Griffiths
  • Vincent C C Wang
  • Christopher J Donnelly
  • Ryosuke Oguro
  • Hannah C Cox
  • Omid Kohannim
  • Takuto Hideyama
  • Weidong Yang
  • Jinghui Zhang
  • Dan Sung C Cho
  • Sieglinde Ebner
  • Yoshiki Danbara
  • Natalia Vasilenko
  • Lin Fang Li
  • Nifang Niu
  • A Kolasa
  • Caterina Cenci
  • Shin Kwak
  • Nurit Paz
  • Denise I Kern
  • S Goding
  • G Roversi
  • Agnieszka Kolasa
  • Takaaki Taguchi
  • A Valenzuela
  • David J Wolyn
  • John M Murray
  • Yi Qun Wang
  • Joshua T Lee
  • Paul A Lindahl
  • Seiji Ito
  • Toshiaki Minami
  • Tsutomu Suzuki
  • Shunpei Okada
  • Shinji Matsumura
  • Jenny Chang-Claude
  • Connie R Bezzina
  • Ellen L Goode
  • Mark Harrison
  • Alice Whittemore
  • Joellen M Schildkraut
  • Elisa V Bandera
  • Joseph Kelley
  • Susan J Ramus
  • Jonathan Flint
  • Andrew Berchuck
  • Madalene Earp
  • Lene Lundvall
  • Peter A Fasching
  • Estrid Hogdall
  • Aleksandra Gentry-Maharaj
  • Kirsten Moysich
  • Ralf Butzow
  • Arimantas Lionikas
  • Russell Joynson

Detail Information

Publications67

  1. ncbi Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles
    A Valenzuela
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona, Catalonia, Spain
    J Immunol 158:3721-9. 1997
    ..Because ADA deficiency leads to severe combined immunodefiency syndrome, it remains possible that HIV particle-mediated blockade of ADA-CD26 interaction may have significant consequences in the pathogenesis of AIDS...
  2. pmc Novel exon of mammalian ADAR2 extends open reading frame
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania, United States of America
    PLoS ONE 4:e4225. 2009
    ..Therefore, the characterization of ADAR expression and identification of alternative ADAR variants is an important prerequisite for understanding the mechanisms for regulation of RNA editing and the causes for deregulation in disease...
  3. doi RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury
    Hitoshi Uchida
    Department of Medical Chemistry, Kansai Medical University, Osaka, Japan
    FASEB J . 2017
    ..after L5 spinal nerve transection (SNT) in adult mice, we found an increase in ADAR2 expression and a decrease in ADAR3 expression in the injured, but not in the uninjured, dorsal root ganglions (DRGs)...
  4. doi Modelling C9ORF72 hexanucleotide repeat expansion in amyotrophic lateral sclerosis and frontotemporal dementia
    Alan Stepto
    Department of Neuroscience, Institute of Psychiatry, King s College London, PO Box 37, 16 De Crespigny Park, London, SE5 8AF, UK
    Acta Neuropathol 127:377-89. 2014
    ..These studies in cell and animal models therefore identify RNA toxicity, RBP sequestration and accumulation of DPRs as emerging pathogenic pathways underlying C9 ALS/FTLD. ..
  5. pmc Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines
    Charlotte J Houldcroft
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom Division of Biological Anthropology, Department of Archaeology and Anthropology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 9:e108384. 2014
    ..This study shows an association between EBV copy number and the gene expression profile of LCLs, and suggests that EBV copy number should be considered as a covariate in future studies of host gene expression in LCLs. ..
  6. doi Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls
    Jon Infante
    Service of Neurology, University Hospital Marqués de Valdecilla IDIVAL, University of Cantabria UC, Santander, Spain Centro de Investigación en Red de Enfermedades Neurodegenerativas CIBERNED, Instituto de Salud Carlos III, Madrid, Spain Electronic address
    Neurobiol Aging 36:1105-9. 2015
    ..We consider that these genes merit further attention in future studies as potential candidate genes involved in both idiopathic and LRRK2-G2019S-associated forms of PD...
  7. pmc Diverse selective regimes shape genetic diversity at ADAR genes and at their coding targets
    Diego Forni
    a Bioinformatics Scientific Institute IRCCS E MEDEA Bosisio Parini, Italy
    RNA Biol 12:149-61. 2015
    ..As for their coding targets, we suggest that most editing events are slightly deleterious, although a minority may be beneficial and contribute to antiviral response and skin homeostasis. ..
  8. pmc Case-control study of ADARB1 and ADARB2 gene variants in migraine
    Claudia F Gasparini
    Menzies Health Institute Queensland, Griffith University Gold Coast, Parklands Drive, Southport, QLD, 4222, Australia
    J Headache Pain 16:511. 2015
    ..The ADARB1 gene was also chosen for investigation due to its important function in editing neurotransmitter receptor transcripts...
  9. doi Identification of SPAG9 as a novel JAK2 fusion partner gene in pediatric acute lymphoblastic leukemia with t(9;17)(p24;q21)
    Machiko Kawamura
    Department of Hematology, Saitama Cancer Center, Saitama, Japan
    Genes Chromosomes Cancer 54:401-8. 2015
    ....
  10. pmc Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing
    Jerome Nicod
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nat Genet 48:912-8. 2016
    ..These findings have implications for diverse areas of mammalian biology and demonstrate how genome-wide association studies can be extended via low-coverage sequencing to species with highly recombinant outbred populations. ..
  11. pmc Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration
    Jennifer B Permuth
    Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA
    Oncotarget 7:72381-72394. 2016
    ..10,891 invasive EOC cases and 21,693 controls, we evaluated the associations of 5,303 SNPs in ADAD1, ADAR, ADAR2, ADAR3, and SND1...
  12. pmc RNA Editing, ADAR1, and the Innate Immune Response
    Qingde Wang
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Genes (Basel) 8:. 2017
    ..Only three members of this protein family, ADAR1-3, exist in mammalian cells. ADAR3 is a catalytically null enzyme and the most significant function of ADAR2 was found to be in editing on the neuron ..
  13. pmc NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies
    Tetsuro Hirose
    Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tokyo 135 0064, Japan Centre National de la Recherche Scientifique, UMR 8122, Institut Gustave Roussy, Villejuif 94805, France Western Australian Institute for Medical Research, Center for Medical Research, University of Western Australia, Perth, Western Australia 6000, Australia Graduate School of Frontier Biosciences, Osaka University, Suita 565 0871, Japan Hitachi, Kokubunji, Tokyo 185 8601, Japan RIKEN Advanced Institute, Wako 351 0198, Japan Centre National de la Recherche Scientifique, FRE 3402, UPMC Universite Paris 06, Paris 75 252, France
    Mol Biol Cell 25:169-83. 2014
    ..These data further confirm that paraspeckles are stress-responsive nuclear bodies and provide a model in which induced NEAT1 controls target gene transcription by protein sequestration into paraspeckles. ..
  14. doi Expression of chicken parvovirus VP2 in chicken embryo fibroblasts requires codon optimization for production of naked DNA and vectored meleagrid herpesvirus type 1 vaccines
    Stephen J Spatz
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 934 College Station Rd, Athens, GA, 30605, USA
    Virus Genes 47:259-67. 2013
    ..However, transient expression of a codon-optimized synthetic VP2 gene cloned into the bicistronic vector pIRES2-Ds-Red2, could be demonstrated by immunocytochemical staining of transfected chicken embryo fibroblasts (CEFs)...
  15. ncbi [Epididymis in an experimental model of DHT deficiency: immunolocalization of ERalpha and ERbeta in rat epididymal epithelial cells. In vivo and in vitro studies]
    Agnieszka Kolasa
    Katedra i Zakład Histologii i Embriologii Pomorskiej Akademii Medycznej, Szczecin
    Ann Acad Med Stetin 52:13-21; discussion 21. 2006
    ..Two isoforms of the 5alpha-red were identified: type 1 (5alpha-redl) and type 2 (5alpha-red2). 5alpha-reductase type 2 is more widely expressed in the epididymis than 5alpha-redl...
  16. doi A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration
    Ryosuke Oguro
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565, Japan
    Exp Gerontol 47:183-7. 2012
    ..There are possibilities that ADAR is associated with major risk factors of atherosclerotic cardiovascular diseases (CVD), such as hypertension, diabetes, dyslipidemia, and obesity...
  17. doi Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons
    Takuto Hideyama
    CREST, Japan Science and Technology Agency, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurobiol Dis 45:1121-8. 2012
    ..In addition, we analyzed the enzymatic activity of three members of the ADAR family (ADAR1, ADAR2 and ADAR3) in ALS motor neurons expressing unedited GluA2 mRNA and those expressing only edited GluA2 mRNA...
  18. pmc A genome-wide analysis of 'Bounty' descendants implicates several novel variants in migraine susceptibility
    Hannah C Cox
    Genomics Research Centre, Griffith Health Institute, Griffith University, Queensland 4222, Australia
    Neurogenetics 13:261-6. 2012
    ..Association of SNPs within these neurotransmitter-related genes suggests a disrupted serotoninergic system that is perhaps specific to the Norfolk Island pedigree, but that might provide clues to understanding migraine more generally...
  19. pmc Discovery and Replication of Gene Influences on Brain Structure Using LASSO Regression
    Omid Kohannim
    Imaging Genetics Center at the Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine Los Angeles, CA, USA
    Front Neurosci 6:115. 2012
    ..8 ± 2.2 SD years). Our approach powerfully complements univariate techniques in detecting influences of genes on the living brain...
  20. ncbi Temperature dependence of methyl-coenzyme M reductase activity and of the formation of the methyl-coenzyme M reductase red2 state induced by coenzyme B
    Meike Goenrich
    Max Planck Institut für Terrestrische Mikrobiologie and Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, Karl von Frisch Strasse, 35043 Marburg, Germany
    J Biol Inorg Chem 10:333-42. 2005
    ..the presence of coenzyme M (HS-CoM) and coenzyme B the MCR-red1 state is in part converted reversibly into the MCR-red2 state, which shows a rhombic Ni(I)-based EPR signal and a UV-vis spectrum with an absorption maximum at 420 nm...
  21. pmc A unified electrocatalytic description of the action of inhibitors of nickel carbon monoxide dehydrogenase
    Vincent C C Wang
    Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, South Park Road, Oxford OX1 3QR, UK
    J Am Chem Soc 135:2198-206. 2013
    ..how these inhibitors target particular oxidation levels of Ni-CODH relating to intermediates (C(ox), C(red1), and C(red2)) that have been established for the active site...
  22. ncbi Remarkably different structures and reaction mechanisms of ketoreductases for the opposite stereochemical control in the biosynthesis of BIQ antibiotics
    Takaaki Taguchi
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Bioorg Med Chem 12:5917-27. 2004
    Two ketoreductases, RED1 and RED2, are involved in the biosynthesis of actinorhodin in Streptomyces coelicolor A3(2) and dihydrogranaticin in S. violaceoruber Tu22, respectively...
  23. ncbi [Construction of recombinant vector expressing ALAS2 gene in X-linked sideroblastic anemia]
    Yi Qun Wang
    Department of Hematology, The First Hospital, Peking University, Beijing 100034, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 12:687-93. 2004
    ..The full length cDNA of ALAS2 gene was inserted into plasmid pDs-red2-N1, named pDs-red2-N1/ALAS2. Then, the vector was transfected into K562 cells via electroporation...
  24. pmc RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
    Christopher J Donnelly
    Department of Neurology, Johns Hopkins University, 855 N Wolfe Street, Rangos 2 270, Baltimore, MD 21205, USA Brain Science Institute, Johns Hopkins University, 855 N Wolfe Street, Rangos 2 270, Baltimore, MD 21205, USA
    Neuron 80:415-28. 2013
    ..These data indicate a toxic RNA gain-of-function mechanism as a cause of C9ORF72 ALS and provide candidate antisense therapeutics and candidate human pharmacodynamic markers for therapy. ..
  25. ncbi Carbon monoxide dehydrogenase from Rhodospirillum rubrum: effect of redox potential on catalysis
    Jian Feng
    Department of Chemistry, Texas A and M University, College Station, Texas 77843 3255, USA
    Biochemistry 43:1552-9. 2004
    ..This cluster can be stabilized in redox states designated C(ox), C(red1), C(int), and C(red2)...
  26. doi Glutamate drugs and pharmacogenetics of OCD: a pathway-based exploratory approach
    Marco A Grados
    Johns Hopkins University School of Medicine, 1800 Orleans St 12th floor, Baltimore, MD 21287, USA 1 443 287 2291 1 410 955 8691
    Expert Opin Drug Discov 8:1515-27. 2013
    ..Concomitantly, there is a growing use of these agents used in the treatment of obsessive-compulsive disorder (OCD)...
  27. ncbi Coenzyme B induced coordination of coenzyme M via its thiol group to Ni(I) of F430 in active methyl-coenzyme M reductase
    Cinzia Finazzo
    Physical Chemistry, ETH Zurich, CH 8093 Zurich, Switzerland
    J Am Chem Soc 125:4988-9. 2003
    ..The evidence is based on X-band continuous wave EPR and Q-band hyperfine sublevel correlation spectroscopy of MCR in the red2 state induced with 33S-labeled coenzyme M and unlabeled coenzyme B.
  28. ncbi Characterization of the MCRred2 form of methyl-coenzyme M reductase: a pulse EPR and ENDOR study
    Cinzia Finazzo
    Physical Chemistry, ETH Zurich, 8093 Zurich, Switzerland
    J Biol Inorg Chem 8:586-93. 2003
    ..inhibited by coenzyme M (HS-CoM) the MCR(red1) signal is partially converted into the rhombic EPR signal MCR(red2)...
  29. ncbi The nickel enzyme methyl-coenzyme M reductase from methanogenic archaea: In vitro induction of the nickel-based MCR-ox EPR signals from MCR-red2
    Felix Mahlert
    Max Planck Institut für Terrestrische Mikrobiologie and Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, Karl von Frisch Strasse, 35043 Marburg, Germany
    J Biol Inorg Chem 7:500-13. 2002
    ..exhibits the axial EPR signal MCR-red1 and in the presence of coenzyme M and coenzyme B the rhombic signal MCR-red2, both derived from Ni(I)...
  30. ncbi The nickel enzyme methyl-coenzyme M reductase from methanogenic archaea: in vitro interconversions among the EPR detectable MCR-red1 and MCR-red2 states
    Felix Mahlert
    Max Planck Institut fur terrestrische Mikrobiologie, Karl von Frisch Strasse, D 35043 Marburg, Germany
    J Biol Inorg Chem 7:101-12. 2002
    ..However, in the presence of coenzyme M and coenzyme B a highly rhombic EPR signal, MCR-red2, was induced, which was found to be light sensitive and appeared to be formed at the expense of the MCR-red1 signal...
  31. ncbi Effect of sodium sulfide on Ni-containing carbon monoxide dehydrogenases
    Jian Feng
    Department of Chemistry, Texas A and M University, College Station, 77843 3255, USA
    J Am Chem Soc 126:9094-100. 2004
    ..82 signal to reappear and activity to recover. Sulfide did not affect the g(av) = 1.86 signal from the C(red2) state. A model was developed in which sulfide binds reversibly to C(red1), inhibiting catalysis...
  32. pmc Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
    Jinghui Zhang
    St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 118:3080-7. 2011
    ..These data extend the range of genes that are recurrently mutated in high-risk childhood B-precursor acute lymphoblastic leukemia and highlight important new therapeutic targets for selected patient subsets...
  33. doi Binding of coenzyme B induces a major conformational change in the active site of methyl-coenzyme M reductase
    Sieglinde Ebner
    Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland
    J Am Chem Soc 132:567-75. 2010
    ..Here we show that the two MCR(red2) signals can also be induced by the S-methyl- and the S-trifluoromethyl analogs of coenzyme B...
  34. pmc SARS coronavirus protein 7a interacts with human Ap4A-hydrolase
    Natalia Vasilenko
    Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK S7N5E3, Canada
    Virol J 7:31. 2010
    ..Human tissue culture cells transiently expressing 7a and Ap4A-hydrolase tagged with EGFP and Ds-Red2 respectively show these proteins co-localize in the cytoplasm.
  35. ncbi [Establishment and characterization of a human gallbladder carcinoma cell line EH-GB1 originated from a metastatic tumor]
    Lin Fang Li
    Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
    Zhonghua Zhong Liu Za Zhi 32:84-7. 2010
    ..To establish a human gallbladder carcinoma cell line derived from a metastatic gallbladder carcinoma and identify its biological characteristics...
  36. doi RNA interference of timeless gene does not disrupt circadian locomotor rhythms in the cricket Gryllus bimaculatus
    Yoshiki Danbara
    Graduate School of Natural Science and Technology, Okayama University, Okayama 700 8530, Japan
    J Insect Physiol 56:1738-45. 2010
    ..b>red2 (dsred2) dsrna...
  37. pmc Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema
    Xiangyang Kong
    Research and Development, GlaxoSmithKline, 709 Swedeland Road, UW2230, King of Prussia, PA 19406, USA
    Am J Respir Crit Care Med 183:43-9. 2011
    ..Pulmonary emphysema is a major but variable component of COPD; familial data suggest that different components of COPD, such as emphysema, may be influenced by specific genetic factors...
  38. pmc Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines
    Nifang Niu
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Genome Res 20:1482-92. 2010
    ..Studies performed with LCLs can help to identify novel biomarkers that might contribute to variation in response to radiation therapy and enhance our understanding of mechanisms underlying that variation...
  39. pmc Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral
    Charles E Samuel
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Virology 411:180-93. 2011
    ..b>ADAR3, by contrast, has not yet been shown to be an active enzyme...
  40. doi Carbon monoxide dehydrogenase reaction mechanism: a likely case of abnormal CO2 insertion to a Ni-H(-) bond
    Patricia Amara
    Laboratoire de Cristallographie et de Cristallogenèse des Protéines, Institut de Biologie Structurale J P Ebel CEA, CNRS, Université Joseph Fourier 41, rue Jules Horowitz, 38027 Grenoble, France
    Inorg Chem 50:1868-78. 2011
    ..the spectroscopically well-characterized catalytic intermediates, C(red1) and the two-electron more-reduced C(red2)...
  41. doi A nickel hydride complex in the active site of methyl-coenzyme m reductase: implications for the catalytic cycle
    Jeffrey Harmer
    Centre for Advanced Electron Spin Resonance, Department of Chemistry, University of Oxford, South Parks Road, OX1 3QR, Oxford, United Kingdom
    J Am Chem Soc 130:10907-20. 2008
    ..We report here on the coordinated ligands of the two paramagnetic MCR red2 states, induced when HS-CoM (a reversible competitive inhibitor) and the second substrate HS-CoB or its analogue ..
  42. pmc Light-response quantitative trait loci identified with composite interval and eXtreme array mapping in Arabidopsis thaliana
    David J Wolyn
    Department of Plant Agriculture, University of Guelph, Ontario N1G 2W1, Canada
    Genetics 167:907-17. 2004
    ..The RED2 and RED5 QTL were verified in segregating lines...
  43. ncbi Localization of a novel human RNA-editing deaminase (hRED2 or ADARB2) to chromosome 10p15
    L Mittaz
    Department of Genetics and Microbiology, University of Geneva Medical School, Switzerland
    Hum Genet 100:398-400. 1997
    ..Here we report the mapping of the human RED2 (hRED2; ADARB2) gene...
  44. ncbi HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26
    A Valenzuela
    Departament de Bioquimica i Biologia Molecular, Facultad de Quimica, Universidad de Barcelona, Spain
    Adv Exp Med Biol 421:185-92. 1997
    ..Since the interaction ecto-ADA/CD26 is required for the activation of T cells, it remains possible that HIV particle-mediated blockade of ecto-ADA/CD26 interaction may have significant consequences in the pathogenesis of AIDS disease...
  45. ncbi Candidate editases for GluR channels in single neurons of rat hippocampus and cerebellum
    G Kohr
    Max Planck Institute for Medical Research, Molecular Neurobiology, Heidelberg, Germany
    Neuropharmacology 37:1411-7. 1998
    ..The recently cloned RNA dependent adenosine deaminases ADAR1, ADAR2 and ADAR3 form a small family of sequence-related candidate editases which are expressed in brain and other tissues at ..
  46. ncbi Reduced editing of low-affinity kainate receptor subunits in optic nerve glial cells
    M P de Zulueta
    Departamento de Neurociencias, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Leioa 48940, Biscay, Spain
    Brain Res Mol Brain Res 73:104-9. 1999
    ..In addition, we found that the adenosine deaminases, DRADA, RED1 and RED2, which edit ionotropic glutamate receptors in the brain, are expressed in the adult optic nerve and in ..
  47. ncbi Evidence for a proposed intermediate redox state in the CO/CO(2) active site of acetyl-CoA synthase (Carbon monoxide dehydrogenase) from Clostridium thermoaceticum
    D M Fraser
    Departments of Chemistry and of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77842, USA
    Biochemistry 38:15706-11. 1999
    ..Subsequent treatment with CO or dithionite yielded C(red2). The EPR-silent state formed within 1 min of adding Ti(3+) citrate, while C(red2) formed after 60 min...
  48. pmc A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains
    C X Chen
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    RNA 6:755-67. 2000
    ..As originally reported for rat ADAR3 or RED2, purified ADAR3 proteins could not edit GluR-B RNA at the "Q/R" site, the "R/G" site, and the intronic "..
  49. ncbi Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes from mammals, pufferfish and zebrafish
    D Slavov
    Eleanor Roosevelt Institute, Denver, CO 80206 1210, USA
    Gene 250:41-51. 2000
    ..In mammals, two such A-to-I RNA editases are RED1, which edits some serotonin and glutamate receptors, and RED2, with unidentified substrates...
  50. ncbi The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression
    J Blanco
    Unité de Virologie et dImmunologie Cellulaire, ERS 572 CNRS, Institut Pasteur, 28 rue Dr Roux, 75724 Paris Cedex 15, France
    FEBS Lett 477:123-8. 2000
    ..These data suggest that the interaction of gp120 with CD4 or CXCR4 is required for efficient inhibition of ADA binding to CD26, although in the presence of CXCR4 the interaction of gp120 with CD4 may be dispensable...
  51. ncbi Comodulation of CXCR4 and CD26 in human lymphocytes
    C Herrera
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona, Marti i Franques 1, 08028 Barcelona, Catalonia, Spain
    J Biol Chem 276:19532-9. 2001
    ..The physical association of CXCR4 and CD26, direct or part of a supramolecular structure, suggests a role on the function of the immune system and the pathophysiology of HIV infection...
  52. ncbi Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA
    Dan Sung C Cho
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:17093-102. 2003
    ..Three vertebrate ADAR gene family members, ADAR1, ADAR2, and ADAR3, have been identified...
  53. ncbi Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Neurosci 18:23-33. 2003
    ..the first quantitative measurements of both mRNAs of the GluR subunits and mRNAs of the RNA editing enzymes ADAR1-ADAR3 in a comparison of the efficiency of editing at the Q/R site with the expression levels of ADAR mRNA in human ..
  54. pmc Preferential accumulation of GABAA receptor gamma 2L, not gamma 2S, cytoplasmic loops at rat spinal cord inhibitory synapses
    Jochen Meier
    Developmental Physiology, Johannes Müller Institute, Humboldt University Medical School Charité, Tucholskystrasse 2, D 10117 Berlin, Germany
    J Physiol 559:355-65. 2004
    ..Furthermore, upon PKC activation Discosoma Red2-tagged GABAAR gamma2L (DsRed 2::gamma2L) colocalized with gephyrin in transfected COS-7 cells...
  55. pmc RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans
    Paola Sebastiani
    Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 4:e8210. 2009
    ..The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered...
  56. pmc ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells
    Weidong Yang
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 280:3946-53. 2005
    ..Here we show that ADAR1 and ADAR2, but not ADAR3, avidly bind short interfering RNA (siRNA) without RNA editing...
  57. ncbi Identification of novel genomic markers related to progression to glioblastoma through genomic profiling of 25 primary glioma cell lines
    G Roversi
    Department of Biology and Genetics, University of Milan, Milan, Italy
    Oncogene 25:1571-83. 2006
    ....
  58. ncbi Targeting of products of genes to tumor sites using adoptively transferred A-NK and T-LAK cells
    S Goding
    Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
    Cancer Gene Ther 14:441-50. 2007
    ..consistently resulted in high (>60%) transduction rates and substantial expression of transgenes such as GFP, Red2, luciferase, beta-galactosidase and mIL-12 for at least 4 days...
  59. pmc Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder
    Gregory L Hanna
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48105, USA
    Biol Psychiatry 62:856-62. 2007
    ..The goal of this study was to identify chromosomal regions likely to contain susceptibility loci for obsessive-compulsive disorder (OCD)...
  60. ncbi Editing of AMPA and serotonin 2C receptors in individual central neurons, controlling wakefulness
    Olga A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, POB 101007, 40001 Dusseldorf, Germany
    Cell Mol Neurobiol 27:669-80. 2007
    ..maximal editing was found in neurons expressing both ADAR2 splice variants of the deaminase domain and lacking ADAR3. (4) Editing of the 5-HT2cR did not correlate with ADAR expression...
  61. ncbi Two sub-states of the red2 state of methyl-coenzyme M reductase revealed by high-field EPR spectroscopy
    Denise I Kern
    Laboratorium fur Physikalische Chemie, ETH Zurich, Wolfgang Pauli Strasse 10, Zurich, Switzerland
    J Biol Inorg Chem 12:1097-105. 2007
    ..Addition of coenzyme B to the MCR-red1 state can partially and reversibly convert it into the MCR-red2 form, which shows a rhombic Ni(I)-based EPR signal (at X-band microwave frequencies of approximately 9.4 GHz)...
  62. pmc Altered adenosine-to-inosine RNA editing in human cancer
    Nurit Paz
    Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Genome Res 17:1586-95. 2007
    ..Altered epigenetic control was recently shown to play a central role in oncogenesis. We suggest that A-to-I RNA editing may serve as an additional epigenetic mechanism relevant to cancer development and progression...
  63. doi Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation
    Caterina Cenci
    RNA editing Laboratory, Ospedale Pediatrico Bambino Gesu Research Institute, Piazza S Onofrio 4, 00165 Rome, Italy
    J Biol Chem 283:7251-60. 2008
    ..However, high expression levels of ADAR1 and ADAR3 were found in tumors when compared with normal tissues dissected in the same area of the brain...
  64. ncbi RED2, a brain-specific member of the RNA-specific adenosine deaminase family
    T Melcher
    Laboratory for Neurobiology, Max Planck Institute for Medical Research, Jahnstrasse 12, 69120 Heidelberg, Germany
    J Biol Chem 271:31795-8. 1996
    ..We now report the molecular cloning of cDNA for RED2 (alias ADARB2), a third member of the RNA-specific adenosine deaminase family in the rodent...
  65. doi Expression of E-SOD, GPX5 mRNAs and immunoexpression of Cu/ZnSOD in epididymal epithelial cells of finasteride-treated rats
    A Kolasa
    Department of Histology and Embryology, Pomeranian Medical University, Szczecin, Poland
    Andrologia 40:303-11. 2008
    ..The 5alpha-reductase is known to exist in two isoforms. Both 5alpha-red1 and 5alpha-red2 catalyse the irreversible conversion of T into DHT...
  66. doi Origins and evolution of ADAR-mediated RNA editing
    Yongfeng Jin
    Institute of Biochemistry, College of Life Sciences, Zhejiang University Zijingang Campus, Hangzhou, Zhejiang, People s Republic of China
    IUBMB Life 61:572-8. 2009
    ..ADAR1 and ADAR2 arose by gene duplications in early metazoan evolution, approximately 700 million years ago, while ADAR3 and TENR might originate after Urochordata-Vertebrata divergence...
  67. pmc Identification of a selective nuclear import signal in adenosine deaminases acting on RNA
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA
    Nucleic Acids Res 37:5822-9. 2009
    ..We identify an in vivo ADAR3 interaction partner, importin alpha 1 (KPNA2) that specifically recognizes an arginine-rich ADAR3 sequence motif ..

Research Grants11

  1. Kazuko Nishikura; Fiscal Year: 2016
    ..This in turn has led to the identification and cloning of ADAR2 and ADAR3. Furthermore, we have created an ADAR1-/- mutation in mice that causes widespread apoptosis and consequent ..
  2. Novel PDEs for Cortical Mapping and Analysis in Disease
    Paul Thompson; Fiscal Year: 2004
    ..abstract_text> ..
  3. Algorithms to Map Disease & Genetic Effects on the Brain
    Paul Thompson; Fiscal Year: 2005
    ..Validated on unique datasets, these tools will greatly empower biomedical studies that bridge imaging and genetics. They will help investigate the genetic transmission, triggers, and dynamics of disease in whole human populations. ..
  4. Computational Modeling of High-Field MR Images
    Paul M Thompson; Fiscal Year: 2010
    ..We will share all images, protocols, and algorithms with our network of 100+ collaborating laboratories. ..
  5. A Multidimensional Alzheimer's Disease Brain Atlas
    Paul M Thompson; Fiscal Year: 2010
    ..We will share all images, protocols, and algorithms with our 100+ collaborating laboratories. ..
  6. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
    ..Based on results from initial analyses and developing collaborations with other research groups future research projects, such as a genome-wide screen of OCD, are considered. ..
  7. Genetic Dissection of Sickle Cell Anemia Phenotypes
    Paola Sebastiani; Fiscal Year: 2006
    ..abstract_text> ..
  8. A novel approach for gene therapy
    Stefan Maas; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. MECHANISM OF INTERFERON ACTION
    CHARLES SAMUEL; Fiscal Year: 2009
    ..Furthermore, elucidation of the actions of IFN at the molecular level is of importance in view of potential applications of interferon in the clinic. ..
  10. MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDER
    GREGORY HANNA; Fiscal Year: 2001
    ..Parametric and nonparametric linkage analyses will be performed. Once evidence for linkage between early-onset OCD and a genetic marker is found, more precise gene localization will be pursued. ..
  11. Regulatory mechanisms for A-to-I RNA editing
    Stefan Maas; Fiscal Year: 2008
    ..The research activities will involve extensive participation of graduate and undergraduate students in the laboratory. [unreadable] [unreadable] [unreadable]..