HPSE2

Summary

Gene Symbol: HPSE2
Description: heparanase 2 (inactive)
Alias: HPA2, HPR2, UFS, UFS1, inactive heparanase-2, heparanase 3, heparanase-like protein
Species: human

Top Publications

  1. pmc Homozygosity and linkage-disequilibrium mapping of the urofacial (Ochoa) syndrome gene to a 1-cM interval on chromosome 10q23-q24
    C Y Wang
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville 32610 0275, USA
    Am J Hum Genet 60:1461-7. 1997
  2. doi Heparanase-2, syndecan-1, and extracellular matrix remodeling in colorectal carcinoma
    Thais Peretti
    Department of Internal Medicine, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Eur J Gastroenterol Hepatol 20:756-65. 2008
  3. ncbi A. baumannii histone acetyl transferase Hpa2: optimization of homology modeling, analysis of protein-protein interaction and virtual screening
    Jyoti Singh Tomar
    a Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India
    J Biomol Struct Dyn . 2016
  4. pmc A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci
    Jonathan P Bradfield
    The Center for Applied Genomics, The Children s Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002293. 2011
  5. doi Genetics of human congenital urinary bladder disease
    Adrian S Woolf
    Centre for Paediatrics Child Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Pediatr Nephrol 29:353-60. 2014
  6. pmc Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations
    Lili Ding
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Hum Genomics 7:16. 2013
  7. doi Urofacial syndrome: a genetic and congenital disease of aberrant urinary bladder innervation
    Adrian S Woolf
    Institute of Human Development, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Pediatr Nephrol 29:513-8. 2014
  8. doi High expression of heparanase-2 is an independent prognostic parameter for favorable survival in gastric cancer patients
    Xiaogang Zhang
    Institute for the Study of Liver Diseases, The Third Hospital of Changzhou, Changzhou 213000, China Electronic address
    Cancer Epidemiol 37:1010-3. 2013
  9. pmc Clinical and genetic characteristics for the Urofacial Syndrome (UFS)
    Yaqin Tu
    The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Ave, Wuhan 430030, China
    Int J Clin Exp Pathol 7:1842-8. 2014
  10. pmc Urinary tract effects of HPSE2 mutations
    Helen M Stuart
    Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre and the Royal Manchester Children s and St Mary s Hospitals, Manchester, United Kingdom
    J Am Soc Nephrol 26:797-804. 2015

Scientific Experts

  • Adrian S Woolf
  • J Waisberg
  • Xiaogang Zhang
  • Junjie Fu
  • Luciano Mr Miller
  • H A F Stephens
  • Jorge Olmos
  • Philipp Beckhove
  • Xu guang Gao
  • Ricardo José Giordano
  • Yona Nadir
  • S Timm
  • Jia Jiang
  • Israel Vlodavsky
  • Neta Ilan
  • Miriam Gross-Cohen
  • Flonia Levy-Adam
  • Yu rong Li
  • Helen M Stuart
  • Gil Arvatz
  • Sarah B Daly
  • Li Fang Zou
  • Sari Feld
  • Thérèse Rachell Theodoro
  • Inna Naroditsky
  • Edward A McKenzie
  • William G Newman
  • Sérgio Mancini Nicolau
  • Gong you Chen
  • Caterina Lupini
  • Jyoti Singh Tomar
  • S K Al-Ouda
  • C Y Wang
  • Maria Aparecida Silva Pinhal
  • Hoda Bazafkan
  • Chunming Guo
  • Roney Cesar Signorini Filho
  • Luiz C S Pinheiro
  • Leandro Luongo Matos
  • Emma N Hilton
  • Helen M Browning
  • Neil A Roberts
  • Mesrur Selcuk Silay
  • Malcolm A Lewis
  • Yaqin Tu
  • Christian Beetz
  • Monika Schmoll
  • Doris Tisch
  • Lili Ding
  • Vinaya Sampath
  • Ilana Doweck
  • Cong Tao
  • Luciano Miller Reis Rodrigues
  • Ping Yang
  • Cong Yi Wang
  • S Mahmood
  • Shu Zhang
  • Christian Seibel
  • Weikuan Gu
  • Renato Moretti Marques
  • Berk Burgu
  • Blanca Gener
  • Jill E Urquhart
  • Wei Guo
  • Eulandria M Biddle
  • Yi Zhou Che
  • Hua Song Zou
  • Wisam Al Badr
  • Ching Hong Yang
  • Maria Aparecida da Silva Pinhal
  • Yi Ping Cui
  • Jonathan P Bradfield
  • Patrícia Gomes-Alves
  • Xu Dong Tang
  • Junfeng Pang
  • Abeer M Al-Subaie
  • Joel Pereira de Moura
  • Li Zhang
  • T J M Wijnhoven
  • Thais Peretti
  • Sonia S D'Souza
  • Jiahuan Zhang
  • Grace Kusumawidjaja
  • R Soundravally
  • G Bar-Sela
  • Melissa Durant
  • Tatsuya Ogishima
  • Zhenning Wang
  • Matthew W Vetting
  • Elena Catelli

Detail Information

Publications71

  1. pmc Homozygosity and linkage-disequilibrium mapping of the urofacial (Ochoa) syndrome gene to a 1-cM interval on chromosome 10q23-q24
    C Y Wang
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville 32610 0275, USA
    Am J Hum Genet 60:1461-7. 1997
    The urofacial (Ochoa) syndrome (UFS) is a rare autosomal recessive disease characterized by congenital obstructive uropathy and abnormal facial expression...
  2. doi Heparanase-2, syndecan-1, and extracellular matrix remodeling in colorectal carcinoma
    Thais Peretti
    Department of Internal Medicine, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Eur J Gastroenterol Hepatol 20:756-65. 2008
    To propose a quantitative method to detect heparanase-2 (HPA2) and syndecan-1 (Syn-1) using immunohistochemistry in colorectal (colon and rectal) carcinomas compared with nonneoplastic tissues and evaluate the possible role of these ..
  3. ncbi A. baumannii histone acetyl transferase Hpa2: optimization of homology modeling, analysis of protein-protein interaction and virtual screening
    Jyoti Singh Tomar
    a Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India
    J Biomol Struct Dyn . 2016
    ..For this purpose, we have identified a novel target Hpa2 of A. baumannii, a member of GNAT superfamily of HATs...
  4. pmc A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci
    Jonathan P Bradfield
    The Center for Applied Genomics, The Children s Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002293. 2011
    ..These latest associated regions add to the growing repertoire of gene networks predisposing to T1D...
  5. doi Genetics of human congenital urinary bladder disease
    Adrian S Woolf
    Centre for Paediatrics Child Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Pediatr Nephrol 29:353-60. 2014
    ..Second, the urofacial syndrome, where mutations of LRIG2 and HPSE2, encoding proteins localised in nerves invading the fetal bladder, have been defined...
  6. pmc Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations
    Lili Ding
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Hum Genomics 7:16. 2013
    ..We performed genome-wide association studies on 859,790 SNPs genotyped in 527 affected offspring trios of European, African, and Hispanic ancestry using publically available asthma database in the Genotypes and Phenotypes database...
  7. doi Urofacial syndrome: a genetic and congenital disease of aberrant urinary bladder innervation
    Adrian S Woolf
    Institute of Human Development, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Pediatr Nephrol 29:513-8. 2014
    ..with urofacial syndrome genetically studied to date carry biallelic, postulated functionally null mutations of HPSE2 or, less commonly, of LRIG2...
  8. doi High expression of heparanase-2 is an independent prognostic parameter for favorable survival in gastric cancer patients
    Xiaogang Zhang
    Institute for the Study of Liver Diseases, The Third Hospital of Changzhou, Changzhou 213000, China Electronic address
    Cancer Epidemiol 37:1010-3. 2013
    ..Heparanase-2 expression has been suggested to up-regulate in several types of human cancers. However, the expression patterns of heparanase-2 in gastric cancer and its effect on prognosis of gastric cancer patients are unclear...
  9. pmc Clinical and genetic characteristics for the Urofacial Syndrome (UFS)
    Yaqin Tu
    The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Ave, Wuhan 430030, China
    Int J Clin Exp Pathol 7:1842-8. 2014
    ..Some patients are also noted with nocturnal lagophthalmos. Until 2010, HPSE2, the gene encodes Heparanse 2 on chromosome 10, was thought to be the only culprit gene for this syndrome...
  10. pmc Urinary tract effects of HPSE2 mutations
    Helen M Stuart
    Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre and the Royal Manchester Children s and St Mary s Hospitals, Manchester, United Kingdom
    J Am Soc Nephrol 26:797-804. 2015
    ..Mutations of HPSE2, encoding heparanase 2, a heparanase 1 inhibitor, occur in UFS, but knowledge about the HPSE2 mutation spectrum is ..
  11. pmc Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion
    Helen M Browning
    Sea Mammal Research Unit, Scottish Oceans Institute, University of St Andrews, Fife, UK
    Proc Biol Sci 281:20140240. 2014
    ..Pv11 was mapped to intron 9 of the heparanase 2 gene (HPSE2) locus, a very large gene encoding heparanase 2, which in humans is associated with multiple carcinomas...
  12. doi Immunohistochemical expression of heparanases 1 and 2 in benign tissue and in invasive neoplasia of the endometrium: a case-control study
    Roney Cesar Signorini Filho
    Departments of Gynecology and Pathology, Universidade Federal de Sao Paulo, São Paulo and Department of Biochemistry, Faculdade de Medicina do ABC, Santo Andre, Sao Paulo, Brazil
    Int J Gynecol Cancer 25:269-78. 2015
    ..In a pioneering way, we sought to evaluate the expression of heparanase 1 (HPSE1) and heparanase 2 (HPSE2) in glandular and in stromal tissues.
  13. pmc A mouse model of urofacial syndrome with dysfunctional urination
    Chunming Guo
    Departments of Urology and Pathology, Boston Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA, Department of Surgery, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 24:1991-9. 2015
    ..Biallelic mutations of HPSE2 are discovered from UFS patients, suggesting that HPSE2 is a candidate disease gene...
  14. pmc Mating type-dependent partner sensing as mediated by VEL1 in Trichoderma reesei
    Hoda Bazafkan
    Department Health and Environment, AIT Austrian Institute of Technology GmbH, BioResources, Konrad Lorenz Strasse 24, Tulln, 3430, Austria
    Mol Microbiol 96:1103-18. 2015
    ..VEL1 impacted regulation of the pheromone system (hpr1, hpr2, hpp1, ppg1) in a mating type-dependent manner and depending on the mating partner of a given strain...
  15. pmc Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression
    Junjie Fu
    Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1600 SW Archer Rd, Health Science Center P5 31, Gainesville, FL, 32610, USA
    BMC Cancer 15:473. 2015
    ..In order to identify biomarkers involved in breast cancer, gene expression profiling was conducted using human breast cancer tissues...
  16. doi Anti-Plasmodium falciparum activity of quinoline-sulfonamide hybrids
    Luiz C S Pinheiro
    Departamento de Síntese de Fármacos, Instituto de Tecnologia em Fármacos, Farmanguinhos Fiocruz, Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro, RJ 21041 250, Brazil
    Bioorg Med Chem 23:5979-84. 2015
    ..05 to 1.63 μM, in the anti-HPR2 assay against clone W2-chloroquine-resistant; ten of them showed an IC50 (ranging from 0.05 to 0...
  17. pmc The Profile of Heparanase Expression Distinguishes Differentiated Thyroid Carcinoma from Benign Neoplasms
    Leandro Luongo Matos
    Biochemistry Department, Faculdade de Medicina do ABC, Santo Andre, Brazil Head and Neck Surgery Department, Faculdade de Medicina do ABC, Santo Andre, Brazil Biochemistry Department, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 10:e0141139. 2015
    ..Heparanase (HPSE) is an endo-beta-glucoronidase implicated in the process of tumor invasion, and the heparanase-2 (HPSE2) modulates HPSE activity...
  18. pmc Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage
    Miriam Gross-Cohen
    Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Oncotarget 7:22556-65. 2016
    While the pro-tumorigenic function of heparanase is well taken, the role of its close homolog, heparanase 2 (Hpa2) in cancer is by far less investigated...
  19. pmc Immunohistochemical expression of heparanase isoforms and syndecan-1 proteins in colorectal adenomas
    J Waisberg
    ABC Medical School
    Eur J Histochem 60:2590. 2016
    ..Primary anti-human polyclonal anti-HPSE and anti-HPSE2 antibodies and primary anti-human monoclonal anti-SDC1 antibody were used in the immunohistochemical study...
  20. pmc Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth
    Miriam Gross-Cohen
    Cancer and Vascular Biology Research Center, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Cancer Res 76:2791-801. 2016
    ..Heparanase-2 (Hpa2) is a close homolog of heparanase that lacks intrinsic HS-degrading activity but retains the capacity to bind HS ..
  21. doi Gene frequency of human platelet alloantigens-1 to -6 and -15 in Saudi blood donors
    S K Al-Ouda
    Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
    Transfus Med 26:220-4. 2016
    ..Typing of HPA (1-6 and 15) has not been carried on the Saudi population. This is the first study of all the seven HPA systems on Arabs. The aim of this prospective study was to determine the frequency of HPA (1-6 and 15) in Saudis...
  22. doi A molecular epidemiology study based on VP2 gene sequences reveals that a new genotype of infectious bursal disease virus is dominantly prevalent in Italy
    Caterina Lupini
    a Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell Emilia BO, Italy
    Avian Pathol 45:458-64. 2016
    ..Four very virulent strains (DV86) and one classical strain (HPR2), together with eight vaccine strains, were also detected...
  23. ncbi Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer
    Tatsuya Ogishima
    Department of Urology, University of California San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Clin Cancer Res 11:1028-36. 2005
    ..We hypothesize that CpG hypomethylation in the heparanase promoter coupled with up-regulation of EGR1 levels may induce heparanase expression in human prostate cancer...
  24. doi Expression of heparanase isoforms in intervertebral discs classified according to Pfirrmann grading system for disc degeneration
    Luciano Miller Reis Rodrigues
    Orthopedic Department, Faculdade de Medicina do ABC, Santo Andre, Brazil
    Spine (Phila Pa 1976) 38:1112-8. 2013
    ..This is a quantitative study of heparanase isoforms expression in degenerative and nondegenerative intervertebral discs (IVDs)...
  25. pmc LRIG2 mutations cause urofacial syndrome
    Helen M Stuart
    Centre for Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester and St Mary s Hospital, Manchester Academic Health Science Centre, Manchester, UK
    Am J Hum Genet 92:259-64. 2013
    ..We have previously shown that UFS is also caused by mutations in HPSE2, encoding heparanase-2...
  26. doi Molecular characterization, expression profiles, and association analysis with hematologic parameters of the porcine HPSE and HPSE2 genes
    Cong Tao
    Laboratory of Molecular Biology and Animal Breeding, Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, China
    J Appl Genet 54:71-8. 2013
    ..b>HPSE2 (heparanase 2) is a homologous gene of HPSE...
  27. pmc The role of pheromone receptors for communication and mating in Hypocrea jecorina (Trichoderma reesei)
    Christian Seibel
    Research Area Gene Technology and Applied Biochemistry, Institute of Chemical Engineering, Vienna University of Technology, 1060 Vienna, Austria
    Fungal Genet Biol 49:814-24. 2012
    ..Here we investigated the role of the two pheromone receptors HPR1 and HPR2 in the H. jecorina pheromone-system...
  28. ncbi The immunoexpression of heparanase 2 in normal epithelium, intraepithelial, and invasive squamous neoplasia of the cervix
    Renato Moretti Marques
    Department of Gynecology, Division of Oncological Gynecology, Federal University of Sao Paulo Paulista School of Medicine, Sao Paulo, Brazil
    J Low Genit Tract Dis 16:256-62. 2012
    Heparanase 2 (HPSE2) is expressed in various tissues, including the brain, intestine, prostate, breast, and endometrium...
  29. pmc Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from Saccharomyces cerevisiae
    Vinaya Sampath
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA
    J Biol Chem 288:21506-13. 2013
    Based on their sequences, the Saccharomyces cerevisiae Hpa2 and Hpa3 proteins are annotated as two closely related members of the Gcn5 acetyltransferase family...
  30. pmc Elucidation of the hrp clusters of Xanthomonas oryzae pv. oryzicola that control the hypersensitive response in nonhost tobacco and pathogenicity in susceptible host rice
    Li Fang Zou
    Key Laboratory of Monitoring and Management for Plant Diseases and Insects, Ministry of Agriculture, Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China
    Appl Environ Microbiol 72:6212-24. 2006
    ..While the region from hpa2 to hpaB and the hrpF operon resembled the corresponding genes of other xanthomonads, the hpaB-hrpF region ..
  31. ncbi Gene polymorphism of platelet glycoprotein I balpha in Chinese patients with large- and small-artery subtypes of ischemic stroke
    Xu guang Gao
    Department of Neurology, Peking University People s Hospital, Beijing, China
    Eur Neurol 54:73-7. 2005
    ..study was to investigate the association between gene polymorphism of GP I balpha (human platelet antigen 2, HPA2) and ischemic stroke in a matched case-control study...
  32. doi Immunopathogenesis of dengue hemorrhagic fever and shock syndrome: role of TAP and HPA gene polymorphism
    R Soundravally
    Department of Molecular Biology and Bioinformatics, Vector Control Research Centre, Pondicherry, India
    Hum Immunol 68:973-9. 2007
    ..the TAP1 gene (using amplification refraction mutation system [ARMS] polymerase chain reaction [PCR]) and HPA1 and HPA2 gene polymorphism (by PCR-sequence specific primers) in different clinical spectrums of dengue infection...
  33. ncbi Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy
    T J M Wijnhoven
    Department of Matrix Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Diabetologia 51:372-82. 2008
    ..Our present study addresses whether heparan sulphate with different modifications is differentially reduced in the GBM and whether heparanase selectively cleaves heparan sulphate with different domain specificities...
  34. ncbi Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells
    Sonia S D'Souza
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    Biol Reprod 78:316-23. 2008
    ..A slight increase in HPSE expression was observed in human stromal fibroblasts decidualized in vitro. HPSE and HPSE2 mRNA transcripts were present in both decidualized tissue and cells...
  35. ncbi Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells
    Grace Kusumawidjaja
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer Biol Ther 6:367-76. 2007
    ..In contrast, BTF3 silencing resulted in down-regulation of several cancer-associated genes, including EPHB2, ABL2, HPSE2 and ATM, and up-regulation of KRAG, RRAS2, NFkappa-B, MRVI1, MADCAM1 and others...
  36. ncbi Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival
    G Bar-Sela
    Department of Oncology, Rambam Medical Centre, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    Histopathology 49:188-93. 2006
    ..To determine the expression and prognostic significance of heparanase in nasopharyngeal carcinoma (NPC)...
  37. pmc Genome-wide relationships between TAF1 and histone acetyltransferases in Saccharomyces cerevisiae
    Melissa Durant
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Mol Cell Biol 26:2791-802. 2006
    ..cerevisiae, nor do we find that TAF1 is functionally redundant with other HATs, including Gcn5, Elp3, Hat1, Hpa2, Sas3, and Esa1, which is in contrast to previous conclusions regarding Gcn5...
  38. pmc Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations
    A Aguilera
    Department of Biochemistry, New York University, New York 10016
    Genetics 119:779-90. 1988
    ..some increase loss of a marker between duplicated genes (hpr1 and hpr6), and some increase both types of events (hpr2, hpr3 and hpr7). New alleles of the CDC2 and CDC17 genes were recovered among these mutants...
  39. ncbi Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis
    Philipp Beckhove
    Tumor Immunology Program, German Cancer Research Center, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 11:2899-906. 2005
    ..We analyzed the presence of heparanase in HNSCC tissues and tumor cells and its potential prognostic significance...
  40. ncbi Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma
    Zhenning Wang
    The Research Center for Medical Genomics and MOH Key Laboratory of Cell Biology, Shenyang, PR China
    Mod Pathol 18:205-11. 2005
    ..In conclusion, laser capture microdissection coupled with RT-PCR is a reliable approach for molecular analysis of heparanase expression in gastric carcinoma. Heparanase may facilitate invasion and metastasis of gastric carcinoma cells...
  41. ncbi A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones
    Matthew W Vetting
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 USA
    Chem Biol 11:565-73. 2004
    ..The AAC(6')-Iy dimer is most structurally similar to the Saccharomyces cerevisiae Hpa2-encoded histone acetyltransferase...
  42. ncbi Genetic system constructed to overproduce and secrete proinsulin in Bacillus subtilis
    J Olmos-Soto
    Biotecnología Marina, P O Box 434844, San Diego, CA 92143 4844, USA
    Appl Microbiol Biotechnol 62:369-73. 2003
    ..A six-protease-deficient strain of B. subtilis with the hpr2 and degU32 mutations was constructed for overproduction of the recombinant protein...
  43. ncbi Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member
    E McKenzie
    Oxford GlycoSciences, 10 The Quadrant, Abingdon Science Park, Abingdon, Oxon, OX14 3YS, United Kingdom
    Biochem Biophys Res Commun 276:1170-7. 2000
    ..Here we report the cloning of a cDNA encoding a novel human protein, HPA2, with significant homology to Hpa1...
  44. pmc Acetylation of histones and transcription-related factors
    D E Sterner
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Microbiol Mol Biol Rev 64:435-59. 2000
    ..yeast to humans, and they include Gcn5-related N-acetyltransferase (GNAT) superfamily members Gcn5, PCAF, Elp3, Hpa2, and Hat1: MYST proteins Sas2, Sas3, Esa1, MOF, Tip60, MOZ, MORF, and HBO1; global coactivators p300 and CREB-..
  45. pmc Identification of two novel hrp-associated genes in the hrp gene cluster of Xanthomonas oryzae pv. oryzae
    W Zhu
    Department of Plant Pathology, Kansas State University, Manhattan, KS 66506, USA
    J Bacteriol 182:1844-53. 2000
    ..vesicatoria and Ralstonia solanacearum. Two new hrp-associated loci, named hpa1 and hpa2, were located beyond the hrpA operon...
  46. ncbi Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily
    M L Angus-Hill
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Mol Biol 294:1311-25. 1999
    We report the crystal structure of the yeast protein Hpa2 in complex with acetyl coenzyme A (AcCoA) at 2.4 A resolution and without cofactor at 2.9 A resolution...
  47. ncbi Construction of a physical and transcript map for a 1-Mb genomic region containing the urofacial (Ochoa) syndrome gene on 10q23-q24 and localization of the disease gene within two overlapping BAC clones (<360 kb)
    C Y Wang
    Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, 32610, USA
    Genomics 60:12-9. 1999
    ..Previously, we mapped the UFS gene to chromosome 10q23-q24 and narrowed the interval to one YAC clone of 1410 kb...
  48. ncbi Genetic homogeneity, high-resolution mapping, and mutation analysis of the urofacial (Ochoa) syndrome and exclusion of the glutamate oxaloacetate transaminase gene (GOT1) in the critical region as the disease gene
    C Y Wang
    Department of Pathology, Immunology and Laboratory Medicine, Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville 32610, USA
    Am J Med Genet 84:454-9. 1999
    The urofacial (Ochoa) syndrome (UFS) is a rare autosomal recessive disorder characterized by abnormal facial expression and urinary abnormalities...
  49. doi Heparanase-2 and syndecan-1 in colon cancer: the ugly ducklings or the beautiful swans?
    Ricardo José Giordano
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Eur J Gastroenterol Hepatol 20:716-8. 2008
    ..issue of the European Journal of Gastroenterology & Hepatology reports the expression of syndecan-1 (Syn-1) and HPA2 in human colorectal cancer samples...
  50. pmc Mutations in HPSE2 cause urofacial syndrome
    Sarah B Daly
    Genetic Medicine, St Mary s Hospital, Manchester Academic Health Sciences Centre MAHSC, School of Biomedicine, University of Manchester, Manchester M13 9WL, UK
    Am J Hum Genet 86:963-9. 2010
    ..an autozygous region of 16 Mb on chromosome 10q23-q24, within which a 10 kb deletion encompassing exons 8 and 9 of HPSE2 was identified...
  51. pmc A cytosolic pathway for the conversion of hydroxypyruvate to glycerate during photorespiration in Arabidopsis
    Stefan Timm
    University of Rostock, Bioscience Institute, Plant Physiology Department, D 18051 Rostock, Germany
    Plant Cell 20:2848-59. 2008
    ..We have identified a second hydroxypyruvate reductase, HPR2, and present genetic and biochemical evidence that the enzyme provides a cytosolic bypass to the photorespiratory ..
  52. doi Human platelet alloantigens (HPA) 1, HPA2, HPA3, HPA4, and HPA5 polymorphisms in sickle cell anemia patients with vaso-occlusive crisis
    Abeer M Al-Subaie
    Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain
    Eur J Haematol 83:579-85. 2009
    ..We investigated the distribution of HPA1, HPA2, HPA3, HPA4, and HPA5 alleles genotypes among VOC and non-VOC control SCA patients.
  53. doi Genome-wide analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of minimal change nephrotic syndrome patients
    Li Zhang
    Second Clinical Medical College, Jinan University, Guangzhou, China
    Am J Nephrol 30:505-13. 2009
    ..This study aimed to investigate the variations in histone H3 lysine 4 trimethylation (H3K4me3) in peripheral blood mononuclear cells of patients with MCNS...
  54. doi HLA and other gene associations with dengue disease severity
    H A F Stephens
    Centre for Nephrology and The Anthony Nolan Trust, University College London, The Royal Free Hospital Campus, Rowland Hill Street, London, NW3 2PF, UK
    Curr Top Microbiol Immunol 338:99-114. 2010
    ..such as mannose binding lectin (MBL), blood related antigens including ABO and human platelet antigens (HPA1 and HPA2)...
  55. ncbi [Expression of the hrcC, hrpE and hpa3 genes is not regulated by the hrpG and hrpX genes in a rice pathogen Xanthomonas oryzae pv. oryzicola]
    Jia Jiang
    Key Laboratory of Monitoring and Management for Plant Diseases and Insects, Ministry of Agriculture, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China
    Wei Sheng Wu Xue Bao 49:1018-25. 2009
    ..However, it is unclear whether the hrpG and hrpX genes regulate all the hrp gene expression of the cluster coordinately or not...
  56. doi Heparanase-2 expression in normal ovarian epithelium and in benign and malignant ovarian tumors
    Joel Pereira de Moura
    Department of Gynecology, Escola Paulista de Medicina, Federal University of Sao Paulo, Sao Paulo, Brazil
    Int J Gynecol Cancer 19:1494-500. 2009
    ..Several papers have associated the expression of heparanase 1 with various malignant tumors. Heparanase 2 is probably related to loss of cell adhesion...
  57. doi Involvement of Heparanase in early pregnancy losses
    Yona Nadir
    Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Health Care Campus, Haifa, Israel
    Thromb Res 125:e251-7. 2010
    ..TH, 2008). Herein, we investigated the role of heparanase in the placenta, focusing on its effect on TF, TFPI, TFPI-2, and vascular endothelial growth factor (VEGF)-A...
  58. doi Rescue of F508del-CFTR by RXR motif inactivation triggers proteome modulation associated with the unfolded protein response
    Patrícia Gomes-Alves
    Laboratório de Proteômica, Departamento de Genetica, Instituto Nacional de Saúde Dr Ricardo Jorge INSA, I P, 1649 016 Lisboa, Portugal
    Biochim Biophys Acta 1804:856-65. 2010
    ..Moreover, the F508del-CFTR-induced proteostasis imbalance, which involves some heat shock chaperones (e.g. HSP72/Hpa2), ER-EF-hand Ca(2+)-binding proteins (calumenin) and the proteasome activator PA28 (PSME2), tends to be 'restored', ..
  59. doi Cytotoxic T lymphocyte epitopes from human heparanase can elicit a potent anti-tumor immune response in mice
    Xu Dong Tang
    Institute of Gastroenterology, Southwest Hospital, Third Military Medical University, 400038, Chongqing, People s Republic of China
    Cancer Immunol Immunother 59:1041-7. 2010
    ..Because heparanase is expressed in most advanced malignant tumors, Hpa525, Hpa277, and Hpa405 peptide-based vaccines may be useful for the immunotherapy of patients with advanced tumors...
  60. pmc Loss-of-function mutations in HPSE2 cause the autosomal recessive urofacial syndrome
    Junfeng Pang
    The Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA
    Am J Hum Genet 86:957-62. 2010
    ..We now report evidence that Heparanse 2 (HPSE2) is the culprit gene for the syndrome...
  61. doi A conserved Hpa2 protein has lytic activity against the bacterial cell wall in phytopathogenic Xanthomonas oryzae
    Jiahuan Zhang
    Department of Plant Pathology, Nanjing Agricultural University, Weigang 1, Nanjing, China
    Appl Microbiol Biotechnol 79:605-16. 2008
    ..In this study, we cloned hrp-associated 2 (hpa2) genes from the bacteria Xanthomonas oryzae pathovars...
  62. pmc Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity
    Flonia Levy-Adam
    Cancer and Vascular Biology Research Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
    J Biol Chem 285:28010-9. 2010
    ..Heparanase homolog, termed heparanase 2 (Hpa2), was cloned based on sequence homology...
  63. pmc Tumorigenic and adhesive properties of heparanase
    Flonia Levy-Adam
    Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
    Semin Cancer Biol 20:153-60. 2010
    ..Pro-adhesive properties of the heparanase homolog, heparanase 2 (Hpa2), are also discussed. Enzymatic activity-independent function of proteases (i.e...
  64. pmc The hydroxypyruvate-reducing system in Arabidopsis: multiple enzymes for the same end
    Stefan Timm
    Department of Plant Physiology, University of Rostock, D 18059 Rostock, Germany
    Plant Physiol 155:694-705. 2011
    ..In addition, a NADPH-dependent cytosolic HPR2 provides an efficient extraperoxisomal bypass...
  65. doi The heparanase system and tumor metastasis: is heparanase the seed and soil?
    Gil Arvatz
    Cancer and Vascular Biology Research Center, Bruce Rappaport Faculty of Medicine, Technion, P O Box 9649, Haifa, 31096, Israel
    Cancer Metastasis Rev 30:253-68. 2011
    ..In this review, we discuss recent progress in heparanase research focusing on heparanase-related molecules namely, cathepsin L and heparanase 2 (Hpa2), a heparanase homolog.
  66. doi First HPSE2 missense mutation in urofacial syndrome
    S Mahmood
    Department of Human Genetics and Molecular Biology, University of Health Sciences, Khayaban e Jamia Punjab, Lahore, Pakistan
    Clin Genet 81:88-92. 2012
    ..Very recently, homozygous loss-of-function mutations affecting the gene HPSE2 were identified in nine cases...
  67. pmc Exome capture and massively parallel sequencing identifies a novel HPSE2 mutation in a Saudi Arabian child with Ochoa (urofacial) syndrome
    Wisam Al Badr
    Division of Nephrology, King Fahad Specialist Hospital Dammam, Dammam, Saudi Arabia
    J Pediatr Urol 7:569-73. 2011
    ..A homozygous mutation was identified in the proband in HPSE2: c...
  68. pmc Hpa2 required by HrpF to translocate Xanthomonas oryzae transcriptional activator-like effectors into rice for pathogenicity
    Yu rong Li
    School of Agriculture and Biology, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, China
    Appl Environ Microbiol 77:3809-18. 2011
    ..Whether or not a putative lytic transglycosylase, Hpa2, interacts with a translocon protein, HrpF, to facilitate bacterial pathogenicity remains unknown...
  69. doi A novel regulatory role of HrpD6 in regulating hrp-hrc-hpa genes in Xanthomonas oryzae pv. oryzicola
    Yu rong Li
    Shanghai Jiaotong University, Shangai, China
    Mol Plant Microbe Interact 24:1086-101. 2011
    ..Interestingly, the expression of hpa2, hpa1, hpaB, hrcC, and hrcT is positively controlled by HrpD6...