HPD

Summary

Gene Symbol: HPD
Description: 4-hydroxyphenylpyruvate dioxygenase
Alias: 4-HPPD, 4HPPD, GLOD3, HPPDASE, PPD, 4-hydroxyphenylpyruvate dioxygenase, 4-hydroxyphenylpyruvic acid oxidase, glyoxalase domain containing 3
Species: human

Top Publications

  1. ncbi Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria
    K Tomoeda
    Department of Pediatrics, Kumamoto University School of Medicine, Kumamoto, Japan
    Mol Genet Metab 71:506-10. 2000
  2. ncbi Human 4-hydroxyphenylpyruvate dioxygenase. Primary structure and chromosomal localization of the gene
    U Ruetschi
    Department of Clinical Chemistry, Gothenburg University, Sahlgren s Hospital, Sweden
    Eur J Biochem 213:1081-9. 1993
  3. ncbi [An autopsied case of chronic active Epstein-Barr virus (EBV) infection with various symptom]
    Y Shizawa
    Department of Internal Medicine, Sagamihara Kyodo Hospital
    Kansenshogaku Zasshi 65:481-7. 1991
  4. ncbi Detection of Mycobacterium tuberculosis in clinical specimens by polymerase chain reaction method
    H G Bi
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 69:272-9. 1995
  5. pmc BCG vaccination of full-term infants with chronic intrauterine malnutrition: influence of immunization age on development of post-vaccination, delayed tuberculin hypersensitivity
    M M Mussi Pinhata
    Department of Puericulture and Pediatrics, , , Brazil
    Bull World Health Organ 71:41-8. 1993
  6. doi Active oxygen intermediates in the degradation of hematoporphyrin derivative in tumor cells subjected to photodynamic therapy
    Lyudmila V Chekulayeva
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
    J Photochem Photobiol B 93:94-107. 2008
  7. ncbi A relationship between varicella-zoster virus-specific delayed hypersensitivity and varicella-zoster virus-induced anterior uveitis
    Takeshi Kezuka
    Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tate machi, Hachioji City, Tokyo, 193 8639, Japan
    Arch Ophthalmol 120:1183-8. 2002
  8. ncbi Effect of endothelin receptor antagonist on parathyroid gland growth, PTH values and cell proliferation in azotemic rats
    Aquiles Jara
    Department of Nephrology, Pontificia Universidad Catolica de Chile, Lira 85, Santiago, Chile
    Nephrol Dial Transplant 21:917-23. 2006
  9. ncbi [Molecular biology of hereditary dystonia]
    T Nagatsu
    Division of Molecular Genetics II Neurochemistry, School of Medicine, Fujita Health University, Aichi
    No To Hattatsu 30:93-100. 1998
  10. ncbi Noninvasive testing of asymptomatic bilateral hilar adenopathy
    P L Carr
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    J Gen Intern Med 5:138-46. 1990

Research Grants

  1. Richard F Silver; Fiscal Year: 2016
  2. CHRISTINA A FISKE; Fiscal Year: 2015
  3. TB Vaccine Candidates Found in Patients'Bodily Fluids and Murine MHC-1 Molecule
    Antonio Campos-Neto; Fiscal Year: 2012
  4. Patrick F Sullivan; Fiscal Year: 2015
  5. Coregulatory Processes and Postpartum Depression in Mexican-Americans
    Linda J Luecken; Fiscal Year: 2013
  6. KRISTINA MARIE DELIGIANNIDIS; Fiscal Year: 2016
  7. Behavioral Change in the Mother/Infant Dyad: Preventing Postpartum Depression
    CATHERINE E MONK; Fiscal Year: 2012
  8. HPA Stress Reactivity &Genetic Influences in Postpartum Depression
    SAMANTHA ERIKA MELTZER-BRODY; Fiscal Year: 2013
  9. Assessing the Influence of Oxytocin on Postpartum Depression Using Brain Imaging
    Julia R Heiman; Fiscal Year: 2010
  10. Eydie L Moses-Kolko; Fiscal Year: 2015

Detail Information

Publications383 found, 100 shown here

  1. ncbi Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria
    K Tomoeda
    Department of Pediatrics, Kumamoto University School of Medicine, Kumamoto, Japan
    Mol Genet Metab 71:506-10. 2000
    The enzyme 4-hydroxyphenylpyruvic acid dioxygenase (HPD) catalyzes the reaction of 4-hydroxyphenylpyruvic acid to homogentisic acid in the tyrosine catabolism pathway...
  2. ncbi Human 4-hydroxyphenylpyruvate dioxygenase. Primary structure and chromosomal localization of the gene
    U Ruetschi
    Department of Clinical Chemistry, Gothenburg University, Sahlgren s Hospital, Sweden
    Eur J Biochem 213:1081-9. 1993
    ..e. amino acids which have been implicated as ligands for iron in 2-oxoacid-dependent dioxygenases. The gene encoding the enzyme was localized to chromosome 12q14-->qter by Southern-blot analysis of human-rodent somatic-cell hybrids...
  3. ncbi [An autopsied case of chronic active Epstein-Barr virus (EBV) infection with various symptom]
    Y Shizawa
    Department of Internal Medicine, Sagamihara Kyodo Hospital
    Kansenshogaku Zasshi 65:481-7. 1991
    ..b>PPD and DNCB skin test were negative...
  4. ncbi Detection of Mycobacterium tuberculosis in clinical specimens by polymerase chain reaction method
    H G Bi
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 69:272-9. 1995
    ..the patients suspected as having tuberculosis by the clinical diagnosis based on the clinical history, characteristic radiographs, a positive PPD skin test and the effectiveness of anti-tuberculous drugs.(ABSTRACT TRUNCATED AT 250 WORDS)
  5. pmc BCG vaccination of full-term infants with chronic intrauterine malnutrition: influence of immunization age on development of post-vaccination, delayed tuberculin hypersensitivity
    M M Mussi Pinhata
    Department of Puericulture and Pediatrics, , , Brazil
    Bull World Health Organ 71:41-8. 1993
    ..The infants were evaluated using post-vaccination skin tests to tuberculin purified protein derivative (PPD) and tuberculin lymphocyte transformation tests...
  6. doi Active oxygen intermediates in the degradation of hematoporphyrin derivative in tumor cells subjected to photodynamic therapy
    Lyudmila V Chekulayeva
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
    J Photochem Photobiol B 93:94-107. 2008
    Hematoporphyrin derivative (HPD), a sensitizer used in photodynamic therapy (PDT) of malignancies, is progressively destroyed during the treatment...
  7. ncbi A relationship between varicella-zoster virus-specific delayed hypersensitivity and varicella-zoster virus-induced anterior uveitis
    Takeshi Kezuka
    Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tate machi, Hachioji City, Tokyo, 193 8639, Japan
    Arch Ophthalmol 120:1183-8. 2002
    ....
  8. ncbi Effect of endothelin receptor antagonist on parathyroid gland growth, PTH values and cell proliferation in azotemic rats
    Aquiles Jara
    Department of Nephrology, Pontificia Universidad Catolica de Chile, Lira 85, Santiago, Chile
    Nephrol Dial Transplant 21:917-23. 2006
    ....
  9. ncbi [Molecular biology of hereditary dystonia]
    T Nagatsu
    Division of Molecular Genetics II Neurochemistry, School of Medicine, Fujita Health University, Aichi
    No To Hattatsu 30:93-100. 1998
    The causative genes of hereditary dystonia (hereditary progressive dystonia, HPD; dopa-responsive dystonia, DRD) were discovered in 1994-1995...
  10. ncbi Noninvasive testing of asymptomatic bilateral hilar adenopathy
    P L Carr
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    J Gen Intern Med 5:138-46. 1990
    ..tests, including the angiotensin-converting enzyme (ACE) assay, gallium scan, and purified protein derivative (PPD), in order to assess when a strategy of watchful waiting is appropriate...
  11. ncbi Picroliv, the iridoid glycoside fraction of Picrorhiza kurroa, selectively augments human T cell response to mycobacterial protein antigens
    S Sinha
    Division of Membrane Biology, Central Drug Research Institute, Lucknow, India
    Immunopharmacol Immunotoxicol 20:579-88. 1998
    ..rhizome of Picrorhiza kurroa, on proliferative T cell response to the mycobacterial 'Purified Protein Derivative (PPD)' antigen in subjects infected with or exposed to mycobacteria (tuberculoid leprosy patients and endemic normals)...
  12. ncbi Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-centre trial of 2 treatment approaches
    J L Wennstrom
    Department of Periodontology, Institute of Odontology, Goteborg University, SE 405 30 Goteborg, Sweden
    J Clin Periodontol 28:753-61. 2001
    ..In the present 6-month multicentre trial, the outcome of 2 different approaches to non-surgical treatment of chronic periodontitis, both involving the use of a locally delivered controlled-release doxycycline, was evaluated...
  13. ncbi Influence of heating on the activity of xanthine oxidase in tumor cells subjected to the phototoxic action of hematoporphyrin derivative
    L Chekulayeva
    Tallinn University of Technology, Estonia
    Neoplasma 54:229-34. 2007
    ..of superoxide radical (O2-*) in tumors subjected to photodynamic therapy (PDT) with hematoporphyrin derivative (HPD)...
  14. doi Permeation of hair dye ingredients, p-phenylenediamine and aminophenol isomers, through protective gloves
    Hsiao Shu Lee
    Department of Public Health, Fu Jen Catholic University, College of Medicine, No 510 Jhongjheng Road, Sinjhuang City, Taipei County, Taiwan
    Ann Occup Hyg 53:289-96. 2009
    ..The predominant oxidative hair dye components, such as p-phenylenediamine (PPD) and aminophenol isomers, can cause contact dermatitis...
  15. ncbi [Application of recombinant 38000 protein antigen of Mycobacterium tuberculosis in screening Mycobacterium tuberculosis infection]
    Xiu Yun He
    Laboratory of Transplantation Center, The 309th Hospital, Chinese People s Liberation Army, Beijing, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:581-4. 2009
    ..To evaluate the potential of recombinant 38000 protein of Mycobacterium tuberculosis (38000 protein) as a tuberculosis-specific tuberculin for screening M. tuberculosis infection...
  16. ncbi [The epidemiologic status of lung tuberculosis in China 1979 and 1984/85. The result of the 2d nationwide randomized prevalence study]
    H Hsu-Yu
    Schanghai Tuberculosis Control Center
    Pneumologie 47:450-5. 1993
    ..territories at 749 randomised locations by means of x-ray and sputum examinations as well as tuberculin tests (PPD)...
  17. pmc Serologic response to culture filtrate antigens of Mycobacterium ulcerans during Buruli ulcer disease
    K M Dobos
    Emory University School of Medicine, Atlanta, GA 30303, USA
    Emerg Infect Dis 6:158-64. 2000
    ..ulcerans antigens and compared this response with delayed-type hypersensitivity responses to both Burulin and PPD. The delayed-type hypersensitivity response generally supported the diagnosis of BU, with overall reactivity to ..
  18. ncbi Hereditary progressive dystonia with marked diurnal fluctuation
    M Segawa
    Segawa Neurological Clinic for Children, 2 8 Surugadai Kanda, Chiyoda ku, 101 0062, Tokyo, Japan
    Brain Dev 22:S65-80. 2000
    Hereditary progressive dystonia with marked diurnal fluctuation or the strictly defined dopa-responsive dystonia (HPD/DRD) is an autosomally dominantly inherited dystonia caused by abnormalities of the gene of the GTP cyclohydrolase I (..
  19. ncbi Post-psychotic depression in schizophrenia
    M Chintalapudi
    Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Eur Arch Psychiatry Clin Neurosci 243:103-8. 1993
    Post-psychotic depression (PPD) is defined as the development of depression during the phase of remission of schizophrenia...
  20. doi Development of parathyroid gland hyperplasia without uremia: role of dietary calcium and phosphate
    Antonio Canalejo
    Department of Environmental Biology and Public Health, University of Huelva, Huelva, Spain
    Nephrol Dial Transplant 25:1087-97. 2010
    ..with parathyroid hormone (PTH) release in normal rats under the physiological demands of a high-phosphate diet (HPD) or a low-calcium diet (LCD). Methods...
  21. ncbi Tyrosinemia I, a model for human diseases mediated by 2-oxoacid-utilizing dioxygenases: hepatotoxin suppression by NTBC does not normalize hepatic collagen metabolism
    Hartmut M Hanauske-Abel
    Departments of Pediatrics and Pathology, New York Presbyterian Hospital, Columbia and Cornell Campuses, Rockefeller University, New York, New York, USA
    J Pediatr Gastroenterol Nutr 35:73-8. 2002
    ..13.11.27) and prolyl 4-hydroxylase (P4-H; E.C. 1.14.11.2), essential for tyrosine and collagen metabolism, respectively...
  22. ncbi Levamisole in the treatment of advanced breast cancer. A ten-year follow-up of a randomized study
    P Klefström
    Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland
    Acta Oncol 30:347-52. 1991
    ..The results correlated with potentiation of intracutaneous PPD test...
  23. ncbi Tissue distribution, intracellular localization and proteolytic processing of rat 4-hydroxyphenylpyruvate dioxygenase
    Søren Neve
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Cell Biol Int 27:611-24. 2003
    4-hydroxyphenylpyruvate dioxygenase (HPD) is an important enzyme involved in tyrosine catabolism. HPD was shown to be identical to a protein named the F-antigen, exploited by immunologists because of its unique immunological properties...
  24. ncbi Under the skin: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes
    Gerhard J Nohynek
    L OREAL Research and Development, Worldwide Safety Department, 25 29 quai Aulagnier, 92600 Asnières, France
    Toxicol Lett 158:196-212. 2005
    ..of the oxidative arylamine (AA) hair dye ingredients [14C]-para-aminophenol (PAP) and [14C]-para-phenylenediamine (PPD) in reconstructed human epidermis and human hepatocytes...
  25. ncbi Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells
    Lyudmila V Chekulayeva
    Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
    J Environ Pathol Toxicol Oncol 25:51-77. 2006
    ..than singlet oxygen (1O2), in the antitumor effect of photodynamic therapy (PDT) with hematoporphyrin derivative (HPD) as well as to determine the ability of photoexcited HPD to the formation of protein peroxides that currently are ..
  26. doi Increased nitric oxide release by neutrophils of a patient with tyrosinemia type III
    Patrizia D'Eufemia
    Department of Pediatrics, University of Roma La Sapienza, Viale Regina Elena 324, 00161 Roma, Italy
    Biomed Pharmacother 63:359-61. 2009
    ..OMIM 276710) is an autosomal recessive disorder caused by the deficiency of 4-hydroxyphenylpyruvate dioxygenase (4-HPD). Few cases have been described with mental retardation or neurological symptoms...
  27. ncbi Clinical assessment of periodontitis in young adults--evaluation of probing depth and partial recording methods
    D M Agerholm
    King's College School of Medicine and Dentistry, London, United Kingdom
    Community Dent Oral Epidemiol 24:56-61. 1996
    ..made between full mouth approximal attachment loss (CAL) assessment and methods relying on pocket probing depth (PPD) evaluation or on partial recording of CAL or PPD...
  28. ncbi Full-mouth ultrasonic debridement versus quadrant scaling and root planing as an initial approach in the treatment of chronic periodontitis
    Jan L Wennström
    Department of Periodontology, Faculty of Odontology, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Clin Periodontol 32:851-9. 2005
    ....
  29. ncbi [The booster phenomenon in two-step tuberculin testing of employees in a community hospital]
    T Fujii
    Imari Municipal Hospital
    Kansenshogaku Zasshi 73:766-71. 1999
    ..phenomenon was present when the employees in a community hospital in Japan received two-step tuberculin testing (PPD)...
  30. ncbi T-cell response to purified protein derivative after removal of Langerhans' cells from epidermal cell suspensions containing keratinocytes expressing class II transplantation antigens
    U Tjernlund
    Department of Dermatology, University of Uppsala, Sweden
    Scand J Immunol 28:667-73. 1988
    ..containing HLA-DR-expressing keratinocytes showed an amplified T-cell response to purified protein derivative (PPD)...
  31. ncbi Inhibition of human lymphocyte proliferative response by serum from Plasmodium falciparum infected patients
    T G Theander
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    Acta Pathol Microbiol Immunol Scand C 95:257-63. 1987
    ..the in vitro lymphocyte proliferative response to both Plasmodium-derived antigens and an unrelated antigen (PPD-tuberculin)...
  32. ncbi DNA or cell kinetics flow cytometry analysis of 33 small gastrointestinal cancers treated by photodynamic therapy
    M T Foultier
    Faculte de Pharmacie, Nantes, France
    Cancer 73:1595-607. 1994
    Photodynamic therapy (PDT) mediated by hematoporphyrin derivative (HPD) is a new treatment for cancers of small volume undergoing Phase II or III clinical trials in various medical fields...
  33. ncbi Gender differences in blue collar workers' use of hearing protection
    S L Lusk
    University of Michigan School of Nursing, Ann Arbor 48109 0482, USA
    Women Health 25:69-89. 1997
    ..Despite the similarities in HPD use and the most important predictors of that use between men and women, the predictive models differed by gender ..
  34. ncbi Interaction of interstitial photodynamic therapy and interstitial hyperthermia in a rat rhabdomyosarcoma--a pilot study
    P C Levendag
    Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 14:139-45. 1988
    ..The photosensitive agent Hematoporphyrin Derivative (HPD) appears to be preferentially retained in malignant tumors; irradiation of HPD-containing tissue by light of ..
  35. ncbi Intradermal and oral immunization with recombinant Mycobacterium bovis BCG expressing the simian immunodeficiency virus Gag protein induces long-lasting, antigen-specific immune responses in guinea pigs
    Mamoru Kawahara
    National Institute of Infectious Diseases, 1 23 1 Toyama, Tokyo 162 8640, Japan
    Clin Immunol 119:67-78. 2006
    ..resulted in the induction of delayed-type hypersensitivity (DTH) responses to both purified protein derivative (PPD) of tuberculin and SIV Gag p27 protein; responses that were maintained for the duration of the 50-week study...
  36. ncbi A mouse model of renal tubular injury of tyrosinemia type 1: development of de Toni Fanconi syndrome and apoptosis of renal tubular cells in Fah/Hpd double mutant mice
    M S Sun
    Department of Pediatrics, Kumamoto University School of Medicine, Japan
    J Am Soc Nephrol 11:291-300. 2000
    ..A new mouse model was developed with two genetic defects, Fah and 4-hydroxyphenylpyruvate dioxygenase (Hpd)...
  37. doi Immigrant and refugee women's post-partum depression help-seeking experiences and access to care: a review and analysis of the literature
    J O'Mahony
    Faculty of Nursing, University of Calgary, Calgary, AB, Canada
    J Psychiatr Ment Health Nurs 17:917-28. 2010
    This literature review on post-partum depression (PPD) presents an analysis of the literature about PPD and the positive and negative factors, which may influence immigrant and refugee women's health seeking behaviour and decision ..
  38. ncbi Effects of gonadotropin-releasing hormone pulse-frequency modulation on luteinizing hormone, follicle-stimulating hormone and testosterone secretion in hypothalamo/pituitary-disconnected rams
    F C Wu
    Department of Anatomy, Monash University, Melbourne, Australia
    Biol Reprod 37:501-10. 1987
    ..gonadotropin-releasing hormone (GnRH) were investigated in 6 adult surgically hypothalamo/pituitary-disconnected (HPD) gonadal-intact rams...
  39. ncbi Outcome in definite and advanced neonatal necrotizing enterocolitis
    Anita Roy
    Department of Pediatric Surgery, Maternity and Children s Hospital, PO Box 2595, Dammam 31176, Kingdom of Saudi Arabia
    Saudi Med J 25:746-52. 2004
    ..To evaluate and compare the outcome of newborns with definite (Bells stage II) and advanced (Bells stage III) necrotizing enterocolitis (NEC) and to assess the role of primary peritoneal drainage...
  40. ncbi Towards more accurate diagnosis of bovine tuberculosis using defined antigens
    J M Pollock
    Veterinary Sciences Division, Stormont, Belfast, UK
    Tuberculosis (Edinb) 81:65-9. 2001
    ..has been shown to be capable of differentiating TB-infected cattle from those which develop responsiveness to PPD through contact with environmental mycobacteria or vaccination with BCG...
  41. ncbi Topical metronidazole application as an adjunct to scaling and root planing
    M Stelzel
    Department of Periodontology, Dental School, Philipps University, Marburg, Germany
    J Clin Periodontol 27:447-52. 2000
    ..This study was carried out to investigate the effect of 2 applications of a metronidazole 25% dental gel as adjunctive therapy to subgingival scaling with root planing...
  42. ncbi Oral vaccination of brushtail possums (Tichosurus vulpecula) with BCG: immune responses, persistence of BCG in lymphoid organs and excretion in faeces
    D N Wedlock
    AgResearch, Wallaceville Animal Research Centre, PO Box 40063, Upper Hutt, New Zealand
    N Z Vet J 53:301-6. 2005
    ..To determine the duration of excretion and longevity of survival of BCG in the faeces of vaccinated animals...
  43. pmc Risk of postpartum depressive symptoms with elevated corticotropin-releasing hormone in human pregnancy
    Ilona S Yim
    Department of Psychology and Social Behavior, University of California Irvine, Irvine, CA 92697 7085, USA
    Arch Gen Psychiatry 66:162-9. 2009
    Postpartum depression (PPD) is common and has serious implications for the mother and her newborn infant...
  44. ncbi Vaccination technique, PPD reaction and BCG scarring in a cohort of children born in Guinea-Bissau 2000-2002
    Adam Roth
    Bandim Health Project, Apartado 861, Bissau, Guinea Bissau
    Vaccine 23:3991-8. 2005
    ..born in suburban Bissau from March 2000 to July 2002, we assessed a Mantoux test with Purified protein derivative (PPD) (SSI, 2 T.U...
  45. ncbi Tuberculosis exposure risk in emergency medicine residents
    A W Asimos
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232 2861, USA
    Acad Emerg Med 6:1044-9. 1999
    To assess purified protein derivative (PPD) test surveillance and respiratory protection practices of emergency medicine (EM) residents, along with the prevalence of PPD test conversion and the development of active tuberculosis (TB) in ..
  46. ncbi Treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. A prospective controlled clinical study
    A Sculean
    Department of Periodontology and Conservative Dentistry, University of Saarland, Homburg, Germany
    J Clin Periodontol 28:397-403. 2001
    ..However, it is yet unknown whether the combination of EMD and GTR may additionally favor the regeneration process...
  47. ncbi Some effects of enamel matrix proteins on wound healing in the dento-gingival region
    Jan L Wennström
    Department of Periodontology, Institute of Odontology, Goteborg University, Sweden
    J Clin Periodontol 29:9-14. 2002
    ..The aim of the present study was to evaluate by clinical means the effect of enamel matrix proteins on the healing of a soft tissue wound produced by periodontal pocket instrumentation...
  48. ncbi Long-term stability of periodontal conditions achieved following guided tissue regeneration with bioresorbable membranes: case series results after 6-7 years
    Andreas Stavropoulos
    Department of Periodontology and Oral Gerontology, Royal Dental College, Aarhus University, Denmark
    J Clin Periodontol 31:939-44. 2004
    ..To evaluate the results of guided tissue regeneration (GTR) treatment of intrabony defects with bioresorbable membranes after 6-7 years, and to disclose factors that may influence the long-term outcome of the treatment...
  49. ncbi Smoking affects the outcome of guided tissue regeneration with bioresorbable membranes: a retrospective analysis of intrabony defects
    Andreas Stavropoulos
    Department of Periodontology and Oral Gerontology, Royal Dental College, Aarhus University, Denmark
    J Clin Periodontol 31:945-50. 2004
    ..To disclose factors that may influence the results of guided tissue regeneration (GTR) treatment in intrabony defects with bioresorbable membranes...
  50. ncbi In vitro genotoxicity of para-phenylenediamine and its N-monoacetyl or N,N'-diacetyl metabolites
    Jean Luc Garrigue
    L OREAL Research and Development, Worldwide Safety Department, 92665 Asnières sur Seine cedex, France
    Mutat Res 608:58-71. 2006
    para-Phenylenediamine (PPD), a widely used ingredient of oxidative hair dyes, is converted by human hepatocytes and in the human epidermis, or after topical application to rats, to its N-monoacetylated (MAPPD) and/or N,N'-diacetylated (..
  51. doi A 6-month study of postpartum depression and related factors in Athens Greece
    Fragiskos Gonidakis
    Department of Psychiatry, Athens University Medical School, Athens, Greece
    Compr Psychiatry 49:275-82. 2008
    Postpartum depression (PPD) affects women in various sociocultural environments around the world during a sensitive period of their lives...
  52. doi Para-phenylenediamine-specific lymphocyte activation test: a sensitive in vitro assay to detect para-phenylenediamine sensitization in patients with severe allergic reactions
    Manfred Kneilling
    Department of Dermatology, Eberhard Karls University, Tubingen, Germany
    Exp Dermatol 19:435-41. 2010
    Patients sensitized to para-phenylenediamine (PPD) by semi-permanent tattoos increasingly develop threatening allergic reactions in response to black hair dye...
  53. ncbi Full-mouth ultrasonic debridement and risk of disease recurrence: a 1-year follow-up
    Cristiano Tomasi
    Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Clin Periodontol 33:626-31. 2006
    ....
  54. doi The psychoneuroimmunology of postpartum depression
    Elizabeth J Corwin
    The Ohio State University, Columbus, Ohio 43210, USA
    J Womens Health (Larchmt) 17:1529-34. 2008
    Postpartum depression (PPD) is a potentially debilitating disorder that develops in a significant percentage of women during the first year after giving birth...
  55. pmc Is survival better at hospitals with higher "end-of-life" treatment intensity?
    Amber E Barnato
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Med Care 48:125-32. 2010
    ..Concern regarding wide variations in spending and intensive care unit use for patients at the end of life hinges on the assumption that such treatment offers little or no survival benefit...
  56. ncbi Photopolymerization of N,N-dimethylaminobenzyl alcohol as amine co-initiator for light-cured dental resins
    Walter F Schroeder
    Institute of Materials Science and Technology INTEMA, Universidad Nacional de Mar del Plata National Research Council CONICET, Av Juan B Justo 4302, 7600 Mar del Plata, Argentina
    Dent Mater 24:686-93. 2008
    The present study was carried out in order to assess the suitability of N,N-dimethylaminobenzyl alcohol (DMOH) as co-initiator of camphorquinone (CQ) and 1-phenyl-1,2-propanedione (PPD) in light-cured dental resins.
  57. ncbi Immune responses of white-tailed deer (Odocoileus virginianus) to Mycobacterium bovis BCG vaccination
    W R Waters
    United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Bacterial Diseases of Livestock Research Unit, PO Box 70, Ames, Iowa 50010 0070, USA
    J Wildl Dis 40:66-78. 2004
    ..In vitro proliferative and interferon-gamma (IFN-gamma) responses to M. bovis purified protein derivative (PPD) were detected beginning 9 days postvaccination...
  58. ncbi A pseudo-response regulator is misexpressed in the photoperiod insensitive Ppd-D1a mutant of wheat (Triticum aestivum L.)
    James Beales
    Crop Genetics Department, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Theor Appl Genet 115:721-33. 2007
    b>Ppd-D1 on chromosome 2D is the major photoperiod response locus in hexaploid wheat (Triticum aestivum)...
  59. doi EUS-guided pancreatic pseudocyst drainage
    Ichiro Yasuda
    First Department of Internal Medicine, Gifu University Hospital, Japan
    Dig Endosc 21:S82-6. 2009
    Endoscopic ultrasound-guided pancreatic pseudocyst drainage (EUS-PPD) has recently become popular. However, this technique has not yet been standardized, and the available instruments have not been sufficiently developed...
  60. doi Is seasonal variation another risk factor for postpartum depression?
    Veena Panthangi
    Department of Family Medicine, St John Hospital and Medical Center, Detroit, MI 48080, USA
    J Am Board Fam Med 22:492-7. 2009
    Postpartum depression (PPD) occurs in the first 6 months after delivery in 10% to 20% of mothers. Despite the availability of screening tools, there is a general consensus that PPD is under-diagnosed...
  61. ncbi Red marrow radiation dose adjustment using plasma FLT3-L cytokine levels: improved correlations between hematologic toxicity and bone marrow dose for radioimmunotherapy patients
    Jeffry A Siegel
    Nuclear Physics Enterprises, Cherry Hill, New Jersey 08003, USA
    J Nucl Med 44:67-76. 2003
    ....
  62. ncbi Sensitivity to sensitins and tuberculin in Swedish children. I. A study of schoolchildren in an urban area
    A Lind
    Department of Medical Microbiology and Immunology, University of Goteborg, Sweden
    Tubercle 72:29-36. 1991
    Non-BCG-vaccinated schoolchildren (8 or 9 years of age) were simultaneously tested on separate arms with 2 IU PPD RT23 and 0.1 microgram Mycobacterium avium sensitin RS10 or 0.1 microgram Mycobacterium scrofulaceum sensitin RS95...
  63. ncbi Enhancement of the efficiency of photodynamic therapy of tumours by t-butyl-4-hydroxyanisole
    I Shevchuk
    Institute of Chemistry of Tallinn Technical University, Estonia
    J Photochem Photobiol B 45:136-43. 1998
    ..prior to light exposure is found to cause concentration-dependent alterations of the haematoporphyrin derivative (HpD)-based PDT. BHA (0...
  64. pmc Sad dads: paternal postpartum depression
    Pilyoung Kim
    Ms Kim is from the Department of Human Development, Cornell University, Ithaca, New York
    Psychiatry (Edgmont) 4:35-47. 2007
    ..Estimates of the prevalence of paternal postpartum depression (PPD) in the first two months postpartum vary in the postpartum period from 4 to 25 percent...
  65. pmc A community-based screening initiative to identify mothers at risk for postpartum depression
    June Andrews Horowitz
    W F Connell School of Nursing, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    J Obstet Gynecol Neonatal Nurs 40:52-61. 2011
    To conduct a community-based, postpartum depression (PPD) screening initiative, and recommend PPD screening practices.
  66. ncbi Effects of bestatin on the host immunity in patients treated for urogenital cancer
    S Ozono
    Department of Urology, Nara Medical University, Japan
    Acta Oncol 29:813-6. 1990
    ..Peripheral lymphocyte, OKT 4/8 ratio and purified protein derivative (PPD) skin reaction were used as immunological markers...
  67. pmc Differential responses of CD45+ve T-cell subsets to MBP in multiple sclerosis
    M Ponsford
    Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, UK
    Clin Exp Immunol 124:315-22. 2001
    ..populations from 20 healthy individuals and 28 multiple sclerosis (MS) patients to purified protein derivative (PPD) and myelin basic protein (MBP) was monitored in a kinetic assay over a period of up to 10 days...
  68. ncbi Galectin-15 in ovine uteroplacental tissues
    C Allison Gray
    Center for Animal Biotechnology and Genomics and Department of Animal Science and Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    Reproduction 130:231-40. 2005
    ..After parturition, galectin-15 mRNA declined in the endometrium from postpartum day (PPD) 1 to 28 and exhibited a variegated expression pattern in the LE and sGE...
  69. pmc Effects of different tuberculin skin-testing regimens on gamma interferon and antibody responses in cattle experimentally infected with Mycobacterium bovis
    M V Palmer
    United States Department of Agriculture, Agricultural Research Service, Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, 2300 Dayton Avenue, Ames, IA 50010, USA
    Clin Vaccine Immunol 13:387-94. 2006
    ..The administration of the CFT and the CCT to M. bovis-inoculated cattle boosted antibody responses to M. bovis PPD, rMPB83, ESAT-6, and the fusion protein Acr1-MPB83. The boosting effect was more pronounced in the 55-day CCT group...
  70. ncbi Primary peritoneal drainage in necrotising enterocolitis: an 18-year experience
    A Goyal
    Department of Paediatric Surgery, Royal Liverpool Children s Hospital, Alder Hey, Liverpool L12 2AP, UK
    Pediatr Surg Int 22:449-52. 2006
    Primary peritoneal drainage (PPD) was initially introduced as a method for the pre-operative resuscitation of critically ill infants with complicated necrotising enterocolitis (NEC)...
  71. pmc Immune responses to defined antigens of Mycobacterium bovis in cattle experimentally infected with Mycobacterium kansasii
    W R Waters
    United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, P O Box 70, Ames, IA 50010 0070, USA
    Clin Vaccine Immunol 13:611-9. 2006
    ..avium and M. bovis PPDs were approximately equivalent, the responses of M. bovis-inoculated calves to M. bovis PPD exceeded their respective responses to M. avium PPD. The gamma interferon and nitrite responses of M...
  72. ncbi The effect of postpartum depression on women's consultations with physicians
    Sophia Eilat-Tsanani
    Department of Family Medicine, Haemek Medical Center, Afula, Israel
    Isr Med Assoc J 8:406-10. 2006
    ..As in other cases of depression, under-diagnosis of PPD may keep patients from getting proper care and increase their physical and emotional distress.
  73. ncbi Mantoux Test as a model for a secondary immune response in humans
    Milica Vukmanovic-Stejic
    Department of Immunology and Molecular Pathology, Division of Infection and Immunity, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, UK
    Immunol Lett 107:93-101. 2006
    ..hypersensitivity (DTH) response to the intradermal injection of tuberculin purified protein derivative (PPD). It represents a cutaneous T cell mediated memory recall immune response...
  74. pmc Lung macrophages from bacille Calmette-Guérin-vaccinated guinea pigs suppress T cell proliferation but restrict intracellular growth of M. tuberculosis after recombinant guinea pig interferon-gamma activation
    A Jeevan
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Clin Exp Immunol 149:387-98. 2007
    ..The total lung digest cells proliferated poorly to purified protein derivative (PPD) but comparatively better to ConA as assessed by [(3)H]-thymidine uptake...
  75. doi Effect of co-initiator ratio on the polymer properties of experimental resin composites formulated with camphorquinone and phenyl-propanedione
    Luis Felipe J Schneider
    Dental School, The University of Passo Fundo, RS, Brazil
    Dent Mater 25:369-75. 2009
    ..DC), Knoop hardness (KH), water sorption (Wsp), water solubility (Wsl) and color changes (DeltaE) over time of resin composites formulated with the photoinitiators camphorquinone (CQ), phenylpropanedione (PPD) and CQ-PPD in combination.
  76. doi Universal tuberculosis screening in pregnancy
    Nadav Schwartz
    Department of Obstetrics and Gynecology, NYU School of Medicine, New York, New York 10016, USA
    Am J Perinatol 26:447-51. 2009
    ..Of 4049 patients, 95.0% were compliant with their purified protein derivative (PPD) testing. Universal screening identified 1935 (50.4%) PPD+ patients, with chest X-rays (CXR) available for 95.1%...
  77. doi p-Phenylenediamine sensitization and occupation
    Andrea Malvestio
    Clinical Unit of Occupational Medicine, University of Trieste, 34129 Trieste, Italy
    Contact Dermatitis 64:37-42. 2011
    p-Phenylenediamine (PPD) is an extreme delayed-type skin sensitizer, and is relevant in both occupational and non-occupational exposures.
  78. doi [Immunodiagnosis and biomarkers in tuberculosis]
    Heinner Guio
    Center for Molecular Microbiology and Infection and Division of Medicine, Imperial College London, United Kingdom
    Med Clin (Barc) 137:408-13. 2011
    ..Some components are present in both, the PPD (used in the tuberculin skin test) and the BCG vaccine...
  79. doi The hair dyes PPD and PTD fail to induce a T(H)2 immune response following repeated topical application in BALB/c mice
    Helga Rothe
    Central Product Safety, The Procter and Gamble Company, Darmstadt, Germany
    J Immunotoxicol 8:46-55. 2011
    1,4-Phenylenediamine (PPD) and the structurally-related 1,4-toluenediamine (PTD) are frequently used oxidative hair dye precursors that can induce a delayed-type hypersensitivity reaction known as contact allergy...
  80. doi Immunogenicity and protective efficacy of a fusion protein vaccine consisting of antigen Ag85B and HspX against Mycobacterium tuberculosis infection in mice
    Q Li
    Lanzhou Center for Tuberculosis Research and Institute of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
    Scand J Immunol 73:568-76. 2011
    ..IgG1 and IgG2a and IFN-γ-secreting T cells upon Ag85B and Mycobacterium tuberculosis purified protein derivative (PPD) stimulation...
  81. doi Identification of novel T cell epitopes from efflux pumps of Mycobacterium tuberculosis
    Yu Huang Zhu
    Department of Bioengineering, Zhengzhou University, 100 Science Road, Zhengzhou 450001, China
    Immunol Lett 140:68-73. 2011
    ..cells (PBMCs) by these peptides could release interferon-γ (IFN-γ) in at least one healthy donor (HLA-A*02(+), PPD(+))...
  82. doi Phylogeography of Sophora davidii (Leguminosae) across the 'Tanaka-Kaiyong Line', an important phytogeographic boundary in Southwest China
    Deng Mei Fan
    Key Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China
    Mol Ecol 22:4270-88. 2013
    ..1.28 Ma (95% HPD: 0.21-2.96 Ma), hence postdating the latest phase of eastern QTP uplift...
  83. doi Incomplete restoration of Mycobacterium tuberculosis-specific-CD4 T cell responses despite antiretroviral therapy
    Denise C Hsu
    The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia HIV Netherlands Australia Thailand Research Collaboration, Thai Red Cross AIDS Research Centre, Bangkok, Thailand Electronic address
    J Infect 68:344-54. 2014
    Despite antiretroviral therapy (ART), HIV-infected persons have increased risk of active tuberculosis (TB). PPD and combined ESAT-6 and CFP-10-specific-CD4 (EC-Sp-CD4) responses were examined over 96 weeks.
  84. doi Measured and perceived environmental comfort: field monitoring in an Italian school
    Valeria De Giuli
    Department of Industrial Engineering, Universita degli Studi di Padova, Via Venezia 1, 35131 Padova, Italy Electronic address
    Appl Ergon 45:1035-47. 2014
    Microclimatic conditions were recorded in an Italian school and Fanger's indexes PMV and PPD were calculated under different conditions...
  85. doi Antidepressant-like effects of omega-3 fatty acids in postpartum model of depression in rats
    Leila Arbabi
    Human Anatomy Laboratory, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia
    Behav Brain Res 271:65-71. 2014
    Postpartum depression (PPD) is a psychiatric disorder that occurs in 10-15% of childbearing women. It is hypothesized that omega-3 fatty acids, which are components of fish oil, may attenuate depression symptoms...
  86. ncbi Postpartum Traditions, Mental Health, and Help-Seeking Considerations Among Vietnamese American Women: a Mixed-Methods Pilot Study
    Van M Ta Park
    Department of Health Science and Recreation, San Jose State University, One Washington Square, MH 514, San Jose, CA, 95192, USA
    J Behav Health Serv Res . 2015
    ..explore Vietnamese American mothers' perceptions and experiences with postpartum traditions, postpartum depression (PPD), and mental health help-seeking behavior...
  87. pmc Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs
    Stefan M Bresson
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Genet 11:e1005610. 2015
    ..In addition, we found that mRNAs with retained introns are susceptible to PABPN1 and PAPα/γ-mediated decay (PPD)...
  88. pmc Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia
    Francis P Pankowicz
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Commun 7:12642. 2016
    ..in vivo, we convert hepatocytes from tyrosinaemia type I into the benign tyrosinaemia type III by deleting Hpd (hydroxyphenylpyruvate dioxigenase)...
  89. doi [Analysis on molecular genetic evolution of Banna virus based on the 12th segment]
    H Liu
    School of Life Sciences, Shandong University of Technology, Zibo 255000, China Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
    Zhonghua Liu Xing Bing Xue Za Zhi 37:1277-1282. 2016
    ..The Bayesian phylogenetic analysis of BAVs revealed that the common ancestor of BAVs appeared 315 (95%HPD: 63-619) years ago...
  90. ncbi Effect of insulin-like growth factor I in murine muscular dystrophy
    M M Zdanowicz
    Department of Pediatrics, North Shore University Hospital Cornell University Medical College, Manhasset, New York 11030, USA
    Endocrinology 136:4880-6. 1995
    ..4-week administration of recombinant human IGF-I (rhIGF-I), both alone and supplemented with a high protein diet (HPD), on muscle metabolism, morphology, and function in the 129 ReJ dystrophic mouse...
  91. ncbi Positive control of the two-component RcsC/B signal transduction network by DjlA: a member of the DnaJ family of molecular chaperones in Escherichia coli
    W L Kelley
    Departement de Biochimie Medicale, Universite de Geneve, Switzerland
    Mol Microbiol 25:913-31. 1997
    ..stimulation of this pathway as deletion, or introduction of the mutation H233Q, within the highly conserved HPD tripeptide abolished all inducing activity...
  92. ncbi Primary human mesothelioma cells express class II MHC, ICAM-1 and B7-2 and can present recall antigens to autologous blood lymphocytes
    L Mutti
    S Maugeri Foundation, Institute for Research and Care, Pavia, Italy
    Int J Cancer 78:740-9. 1998
    ..MMc were pulsed with purified protein derivative (PPD), Tetanus toxoid (TT) and Candida albicans (CA) bodies, and incubated with autologous lymphocytes...
  93. ncbi An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro
    A M Kamal
    Academic Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Charing Cross Campus, Fulham Palace Road, London W6 8RF, UK
    Clin Exp Allergy 31:1116-25. 2001
    ..Although it has been shown to inhibit "macroscopic" inflammatory processes in animal models, its direct effects on antigen-activated human T cells have not been studied...
  94. ncbi Characterization of transplastomic tobacco plants with a plastid localized barley 4-hydroxyphenylpyruvate dioxygenase
    Jon Falk
    Institute of Botany, Christian Albrechts University of Kiel, Olshausenstr 40, 24098 Kiel, Germany
    J Plant Physiol 162:738-42. 2005
    The 4-hydroxyphenylpyruvate dioxygenase (HPD) is the only enzyme of the biosynthetic pathway of tocopherols and tocotrienols localized outside of plastids...
  95. ncbi New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria
    Thorsten Selmer
    Laboratorium für Mikrobiologie, Philipps Universitat Marburg, D 35032 Marburg, Germany
    Biol Chem 386:981-8. 2005
    ..These include benzylsuccinate synthase (Bss), 4-hydroxyphenylacetate decarboxylase (Hpd) and the coenzyme B12-independent glycerol dehydratase (Gdh)...
  96. ncbi Parkinson's disease, chronic hydrocarbon exposure and striatal neuronal damage: a 1-H MRS study
    M Rango
    Dipartimento di Scienze Neurologiche Centro per il Morbo di Parkinson, Ospedale Maggiore Policlinico, IRCCS, Universita degli Studi di Milano, Milano, Italy
    Neurotoxicology 27:164-8. 2006
    ..Twenty normal subjects without previous exposure to hydrocarbon-solvents and matched for age and sex with HPD patients were studied for comparison...
  97. ncbi Vaccine-induced cytokine responses in a guinea pig model of pulmonary tuberculosis
    D N McMurray
    Department of Medical Microbiology and Immunology, Texas A and M University System Health Science Center, 463 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Tuberculosis (Edinb) 85:295-301. 2005
    ..of anti-TGFbeta on day 8 following pleurisy induction resulted in significant changes in cytokine mRNA levels and PPD-induced proliferation in pleural effusion lymphocytes taken 24h later...
  98. pmc A genomewide analysis of genes for the heat shock protein 70 chaperone system in the ascidian Ciona intestinalis
    Shuichi Wada
    CREST, Japan Science Technology Agency, Kawaguchi, Saitama 333 0012 corrected Japan
    Cell Stress Chaperones 11:23-33. 2006
    ..There is also a J-like protein without a conserved HPD tripeptide motif in the Ciona genome...
  99. pmc Changes in leucocyte and lymphocyte subsets during tuberculosis treatment; prominence of CD3dimCD56+ natural killer T cells in fast treatment responders
    H Veenstra
    Division of Molecular Biology and Genetics and MRC Centre for Molecular and Cellular Biology, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Clin Exp Immunol 145:252-60. 2006
    ..patients with positive sputum cultures during therapy in comparison with 14 healthy purified protein derivative (PPD)-positive volunteers...
  100. ncbi A general population from Thailand: incidence of common allergens with emphasis on para-phenylenediamine
    J M L White
    Department of Cutaneous Allergy, St Thomas Hospital, St John s Institute of Dermatology, London, UK
    Clin Exp Allergy 37:1848-53. 2007
    Most studies on the prevalence of allergy to the permanent hair dye chemical para-phenylenediamine (PPD) are reported from populations of eczema patients attending patch-test clinics, and are assumed to be much higher than in the normal ..
  101. pmc Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program
    Kieran G Meade
    Comparative Immunology Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    BMC Genomics 9:447. 2008
    ..n = 6) and healthy control (n = 6) cattle to stimulation with bovine tuberculin (purified protein derivative - PPD-b) in vitro. PBMC were harvested before, and at 3 h and 12 h post in vitro stimulation with bovine tuberculin...

Research Grants72

  1. Richard F Silver; Fiscal Year: 2016
    ..novel protocol of segmental bronchoscopic challenge with the skin-test reagent purified protein derivative of Mtb (PPD)...
  2. CHRISTINA A FISKE; Fiscal Year: 2015
    ..tuberculosis infection, and healthy controls who are not infected with M. tuberculosis (PPD negative). The Aims will be investigated using an in vitro model of macrophage stimulation and infection with M...
  3. TB Vaccine Candidates Found in Patients'Bodily Fluids and Murine MHC-1 Molecule
    Antonio Campos-Neto; Fiscal Year: 2012
    ..initial studies that demonstrated that some of the these novel antigens are readily recognized by PBMC from healthy PPD positive individuals and less so by PBMC of patients with tuberculosis and induce protective immunity...
  4. Patrick F Sullivan; Fiscal Year: 2015
    ..To minimize heterogeneity, we will study postpartum depression (PPD), a more homogenous type of MDD...
  5. Coregulatory Processes and Postpartum Depression in Mexican-Americans
    Linda J Luecken; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The consequences of postpartum depression (PPD) extend far beyond the mother's mental health, and can have severe detrimental effects on marital relationships, parenting abilities, mother-infant ..
  6. KRISTINA MARIE DELIGIANNIDIS; Fiscal Year: 2016
    ..physician-scientist is to: discover neuroendocrine and neuroimaging endophenotypes in postpartum depression (PPD), translate findings to develop methods to identify pregnant women at highest risk of developing PPD based on ..
  7. Behavioral Change in the Mother/Infant Dyad: Preventing Postpartum Depression
    CATHERINE E MONK; Fiscal Year: 2012
    ..7%). Existing clinical approaches to postpartum depression (PPD) use standard pharmacologic and psychological interventions to reduce women's symptoms...
  8. HPA Stress Reactivity &Genetic Influences in Postpartum Depression
    SAMANTHA ERIKA MELTZER-BRODY; Fiscal Year: 2013
    ..In particular, postpartum depression (PPD) has a prevalence rate of approximately 10%, making it one of the most common complications of both the prenatal ..
  9. Assessing the Influence of Oxytocin on Postpartum Depression Using Brain Imaging
    Julia R Heiman; Fiscal Year: 2010
    ..provided by applicant): Following the birth of an infant, 10-15% of women experience postpartum depression (PPD) (Halbreich &Karkum, 2006)...
  10. Eydie L Moses-Kolko; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): PROJECT SUMMARY Postpartum depressive disorders (PPD;including major and minor depression) constitute a public health crisis with potentially long-term, adverse consequences for the woman, her child ..
  11. Maureen G Phipps; Fiscal Year: 2016
    ..US each year are to adolescent mothers and approximately 26-36% of these mothers experience postpartum depression (PPD), a condition associated with significant social and health morbidity...
  12. Alison M Stuebe; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Postpartum depression (PPD) is a common, morbid condition that affects 10-15% of mothers...
  13. Social Media, Teen Moms, and PPD
    MIMIA CYNTHIA LOGSDON; Fiscal Year: 2013
    ....
  14. RAYMOND SAM NIEDBALA; Fiscal Year: 2014
    ..in significantly enhanced reactivity (compared to unconjugated peptides) with sera from TB patients, but not from PPD+ subjects...
  15. Psychoneuroimmune Contributions to Postpartum Depression
    ELIZABETH JEANNE CORWIN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Postpartum depression (PPD) occurs in up to 20 percent of postpartum women, and carries consequences that may last a lifetime...
  16. De Kun Li; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Postpartum depression (PPD) afflicts about 10-15% of pregnant women. Depression during pregnancy is the strongest risk factor for PPD...
  17. LORI ELIZABETH ROSS; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Postpartum depression (PPD) is a significant public health issue for women and their families (5), yet research to date has focused almost exclusively on heterosexual married women (102)...
  18. Resilient Profiles and Postpartum Depression in Low-Income Mexican American Women
    Jenna L Gress-Smith; Fiscal Year: 2012
    ..Studies estimate postpartum depression (PPD) to be more prevalent in MA mothers, ranging from 21-53%, compared to 10-15% in other samples of postpartum women...
  19. TRIP for postpartum depression (TRIPPD)
    Barbara Yawn; Fiscal Year: 2009
    Postpartum depression (PPD) is a common, serious condition affecting over 500,000 women annually in the United States. PPD is associated with significant morbidity and mortality, affecting new mothers, their infants and their families...
  20. Placebo Controlled Trial of Sertraline and IPT for Postpartum Depression
    Scott P Stuart; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Postpartum depression (PPD) is a serious mental illness that affects more than 500,000 US women every year...
  21. Placebo Controlled Trial of Sertaline and IPT for Postpartum Depression
    Caron Zlotnick; Fiscal Year: 2012
    Postpartum depression (PPD) is a serious mental illness that affects more than 500,000 US women every year. In addition to the suffering experienced by women, it has profound effects on women's families and their developing infants...
  22. Crystal Edler Schiller; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Affective disorders, such as postpartum depression (PPD) and other reproductive-related mood disorders, are common and constitute a significant burden for women, children, and society...
  23. Facilitating Effective Referrals for Postpartum Depression
    Rhonda C Boyd; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Project Summary Postpartum depression (PPD) is a significant mental health and public health problem. It is estimated that 10-15% of women suffer from major depression after childbirth...
  24. Development of a Home-Based Family Treatment for Postpartum Depression
    Cynthia L Battle; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Although 10-15% of women experience postpartum depression (PPD) after giving birth to a child, the majority do not receive any form of mental health treatment...
  25. TB Diagnosis Based on Promiscuous PE-PGRS Epitopes
    Suman Laal; Fiscal Year: 2010
    ..the immunodominant epitopes that are recognized by serum antibodies from HIV-TB+ and HIV+TB+ patients but not by PPD-, PPD+ and/or BCG vaccinated healthy subjects or HIV+TB- controls (Aim #2) and c) Evaluate the reactivity of ..
  26. A multi-scale and multi-system approach to understand granuloma formation in TB
    STEVEN LYNN KUNKEL; Fiscal Year: 2010
    ..tuberculosis antigen (PPD) coated beads in vivo, M. tuberculosis infection in mice and non-human primates, and multi-scale in silico models...
  27. Functional status and motor activity in PPD
    Barbara Posmontier; Fiscal Year: 2005
    ..However, a woman suffering from postpartum depression (PPD) may be unable to function in her new role and perform activities that are vital to her own and family's well-being...
  28. "Post-partum steroid withdrawal-induced depression"
    REBECCA CRAFT; Fiscal Year: 2006
    Up to 15% of child-bearing women develop postpartum depression (PPD) in the weeks following delivery. Similar to major depression, PPD puts women at increased risk for the development of other psychological disorders (e.g...
  29. Antepartum Interpersonal Psychotherapy at 3 NYC Sites
    Margaret Spinelli; Fiscal Year: 2009
    ..APD is one of the best predictors of postpartum depression (PPD), which in turn causes impaired infant and childhood emotional and cognitive development...
  30. A New Tuberculin for the Diagnosis of Tuberculosis
    Leo Einck; Fiscal Year: 2001
    ..Because of the cross-reactive nature of purified protein derivative (PPD) of tuberculin, TST currently does not discriminate between infection with M. tuberculosis, vaccination with M...
  31. Relational Group Intervention for Postpartum Depression
    Roseanne Clark; Fiscal Year: 2005
    ..One of the major mechanisms by which PPD may influence infant outcomes is through its impact on the quality of the mother's affective and behavioral ..
  32. Postpartum Depression in a Pediatric Clinic
    Linda Chaudron; Fiscal Year: 2006
    ..Postpartum depression (PPD) is a serious public health problem affecting 10-20% of American women...
  33. Latent and Reactivation Tuberculosis
    Joanne Flynn; Fiscal Year: 2007
    ..Compared to the 10% lifetime risk of a PPD+ person developing tuberculosis, an HIV+PPD+ person has a 10% annual risk of this disease...
  34. HEAT SHOCK PROTEIN RECOGNITION/GAMMA-DELTA T CELL SUBSET
    REBECCA O BRIEN; Fiscal Year: 1993
    ..simply cultured by themselves in medium; all members of this group are further stimulated by mycobacterial antigen (PPD)...
  35. DISSEMINATED TUBERCULOSIS IN HIV INFECTION
    C von Reyn; Fiscal Year: 2004
    ..Baseline evaluation will include history, chest x-ray, dual skin tests with purified protein derivative (PPD) and Mycobacterium avium sensitin (MAS), and whole blood assay for interferon-gamma production in response to MV ..
  36. IMMUNE RESPONSE IN THE LUNG TO TB PROTEINS IN AIDS
    William Rom; Fiscal Year: 2002
    ..He will compare their response to PPD+ and PPD- healthy individuals...
  37. Genetic/Immunological Basis of Tuberculosis and Anergy
    Julio Delgado; Fiscal Year: 2005
    ..that HLA molecules are functionally associated with tuberculosis progression and differential immune response to PPD and whether polymorphisms of the promoter region of certain cytokines are associated with impaired immune response ..
  38. IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASES
    Zahra Toossi; Fiscal Year: 2001
    ..M. tuberculosis, its PPD, and its cell wall antigens induce monocytes to production of TGF-beta...
  39. C NEILL NEILL EPPERSON; Fiscal Year: 2014
    ..to inform our investigations of the pathogenesis of premenstrual dysphoric disorder (PMDD), postnatal depression (PPD), and perimenopausal mood and cognitive changes...
  40. Carboxylesterase-activated Doxazolidine-prodrug for Hepatocellular Carcinoma
    Tad H Koch; Fiscal Year: 2012
    ..The prodrug of doxazolidine, N-(pentyloxycarbonyl-p-aminobenzyloxycarbonyl)doxazolidine (pentyl PABC- Doxaz, PPD), is activated by CES2 present in liver, colon, lung, kidney, thyroid, and pancreatic cancer cells...
  41. Christopher A Bradfield; Fiscal Year: 2014
    ..similar to those observed in human corneal endothelial dystrophies, notably posterior polymorphous dystrophy (PPD), and the sporadic condition, iridocorneal endothelial syndrome (ICE)...
  42. Development of a CES 2-Activated Doxazolidine Prodrug for Pancreatic Cancer
    Tad H Koch; Fiscal Year: 2010
    ..The prodrug of doxazolidine, N-(pentyloxycarbonyl-p-aminobenzyloxycarbonyl)doxazolidine (pentyl PABC- Doxaz, PPD), is activated by CES2 in pancreas, liver, lung and kidney cancer cells amongst other cancer cells...
  43. Estimation of Periodontal Disease Progression in the Presence of Diagnostic Error
    Anthony Parker; Fiscal Year: 2011
    ..In periodontal research studies, the probed pocket depth (PPD) is one measure often used to assess periodontal disease status...
  44. Data Coordinating Center for Organ Transplant Clinical *
    Jun Liu; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): PPD, Inc...
  45. Cloning/Gene/Posterior Polymorphous corneal dystrophy
    ANTHONY ALDAVE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Posterior polymorphous corneal dystrophy (PPCD, PPMD, PPD;OMIM # 122000) is a dominantly inherited disorder of the corneal endothelium that is associated with a wide spectrum of clinical features and ..
  46. David N Ikle; Fiscal Year: 2014
    ..the Statistical and Data Coordinating Center (SDCC) contract for the Immune Tolerance Network (ITN) from PPD, so it is well-qualified to transition the SACCC from PPD to RhoFED with as little disruption in the activities of ..
  47. Establishment of an H3Africa Biorepository at Contract Laboratory Services
    Ute Jentsch; Fiscal Year: 2013
    ..SANAS) since 1999" accreditation for the CLS laboratory through the British Quality Group "DAIDS approved through PPD and FHI monitoring" IATA and LDMS certification of its repository...
  48. SURGERY FOR NEC IN HUMAN INFANTS-- A RANDOMIZED TRIAL
    R Moss; Fiscal Year: 2002
    ..Simple primary peritoneal drainage (PPD) of the abdominal cavity is a novel, minimally invasive alternative...
  49. EFFICACY OF TB CHEMOPROPHYLAXIS IN PPD, HIV ADULTS
    Jacqueline Coberly; Fiscal Year: 1999
    ..Skin testing with purified protein derivative (PPD) is normally used to identify people co-infected with HIV and M...
  50. GENETIC FACTORS AND SUSCEPTIBILITY TO TUBERCULOSIS
    Anne Goldfeld; Fiscal Year: 2006
    ..We have also uncovered a high incidence of antigen-specific anergy to PPD (purified protein derivative) among patients with active pulmonary disease that persists following successful cure...
  51. Genetic Mechanisms of Vertebrate Caudal Limb Field Specification
    JEFFREY INNIS; Fiscal Year: 2007
    ..In this proposal we will use a new, spontaneous, dominant mouse mutant, Polypodia (Ppd) that exhibits ectopic caudal limbs as a novel way to identify new, upstream genetic pathways that underlie the ..
  52. MOLECULAR BASIS OF PREAXIAL POLYDACTYLY TYPE 2
    Anne Hing; Fiscal Year: 1999
    ..Patients with PPD have a polydactyly of the thumbs, fingers or toes...
  53. AIDS AS A CAUSE FOR PRIMARY OPTIC NEUROPATHY
    Alfredo Sadun; Fiscal Year: 1991
    ..This axonal loss did not appear to correlate with the use of certain medication regimens. We will utilize the PPD method for identifying degeneration in the optic nerves of patients with AIDS on various treatment modalities and ..
  54. RISK FACTORS FOR EXTRAPULMONARY TUBERCULOSIS
    Timothy Sterling; Fiscal Year: 2004
    ..to mitogen stimulation in HIV- seronegative adults with extrapulmonary TB compared to the cytokine response in PPD+ adults without active TB...
  55. CORRELATES OF PROTECTIVE IMMUNITY IN TUBERCULOSIS
    Gilla Kaplan; Fiscal Year: 2000
    ..The specific aims of this project are: (1) To determine whether there is a difference in immune activation among PPD+ individuals (patients and controls), following varying types of exposure to mycobacterial antigens, in specific ..
  56. Transdermal Test for Active Tuberculosis
    Carol Nacy; Fiscal Year: 2001
    ..b>PPD+ symptomless individuals are non-reactive to the protein...
  57. STUDIES OF REACTIVATION TUBERCULOSIS IN HIV INFECTION
    Anne De Groot; Fiscal Year: 1993
    ..in certain immune responses in HIV+ patients, HIV- infected (HIV+) and uninfected (HIV-) subjects who have no TB (PPD-), latent TB (PPD+) or active TB will be compared for a variety of relevant clinical and immunological parameters ..
  58. HUMAN T CELL RESPONES TO MYCOBACTERIUM TUBERCULOSIS
    DAVID LEWINSOHN; Fiscal Year: 2001
    ..We have found that these proteins elicit vigorous T cell proliferation and interferon-gamma production from healthy PPD positive individuals, and that one of these proteins is preferentially expressed in cells infected with live Mtb...
  59. Promoting Adherence to TB Regimens in High-Risk Youth
    Melbourne Hovell; Fiscal Year: 2007
    ..The proposed study will demonstrate a public health program for TB control among PPD+ adolescents and conduct a controlled trial of peer counseling plus parent education for adherence to INH...
  60. TB/HIV RISK REDUCTION WITH HOMELESS AND DRUG ADDICTED
    Adeline Nyamathi; Fiscal Year: 2002
    ..is known about the efficacy of intervention studies focused on enhancing completion of TB prevention programs among PPD positive homeless men and women, many of whom are addicted to drugs and alcohol, at risk for active TB, hard to ..
  61. Stepped Care Treatment of Postpartum Depression
    Dwenda Gjerdingen; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by PI): Postpartum depression (PPD), seen in approximately 10-20% of women who give birth, is the most common serious postpartum health disorder, with documented effects on mothers' physical and ..
  62. The association of obesity and postpartum depression
    DAPHNE LACOURSIERE; Fiscal Year: 2006
    ..In women of reproductive age, obesity has been associated with depression. Postpartum depression (PPD) affects 10-15% of all women, especially those with a history of pre-existing depression...
  63. COCAINE & MATERNAL AGGRESSION--OXYTOCINERGIC MECHANISMS
    JOSEPHINE JOHNS; Fiscal Year: 2005
    ..intruder (maternal aggression) and reduce the levels of oxytocin (OXY) in the amygdala of rats on postpartum days (PPD) 6-10...
  64. MOLECULAR STRUCTURE OF STEROIDS
    William Duax; Fiscal Year: 2001
    ..analogue will be used to model inhibition of mammalian 11beta-HSD and 15-hydroxy prostaglandin dehydrogenase (15-HPD). Inhibition of the former induces hypertension and of the latter combats peptic ulcers...
  65. FAST PHOTOSENSITIZED REACTIONS OF AROMATIC COMPOUNDS
    LEONARD GROSSWEINER; Fiscal Year: 1992
    ..of light scattering liposomes and resealed beef erythrocyte membranes incorporating a hematoporphyrin derivative (HPD) preparation, and selected alternative PDT sensitizers, will be employed to study the effects of wavelengths, ..
  66. SELECTIVE PHOTOCHEMOTHERAPY: DEVELOPMENT AND APPLICATION
    Allan Oseroff; Fiscal Year: 1991
    ..Most currently employed PS such as hematoporphyrin derivative (HPD) do not have high levels of preferential accumulation in their target cells...
  67. PHOTOTHERAPY OF BLADDER CANCER: NEW PHOTOSENSITIZERS
    Chi Wei Lin; Fiscal Year: 1991
    ..in basic studies and in preclinical and clinical development of this treatment using hematoporphyrin derivative (HPD) as the photosensitizer. Phase III clinical trials for HPD-phototherapy are now underway...
  68. Investigation of the role of bacteria in the sarcoidosis trimolecular complex
    Wonder Drake; Fiscal Year: 2009
    ..noted IgG antibodies to recombinant MTB katG in sera from 48% of sarcoidosis patients compared to 0% in sera from PPD negative controls (p=0.0059)...
  69. PULSED SOLID-STATE LASER SOURCE FOR PHOTODYNAMIC THERAPY
    PETER MOULTON; Fiscal Year: 1992
    DESCRIPTION (Adapted from applicant's abstract):Photodynamic therapy (PDT) utilizing hematoporphyrin derivative (HPD) and a cw argon-pumped dye laser tuned to 630 nm has been shown to be a promising treatment for a number of forms of ..