hormone sensitive lipase

Summary

Gene Symbol: hormone sensitive lipase
Description: lipase E, hormone sensitive type
Alias: AOMS4, FPLD6, HSL, LHS, hormone-sensitive lipase, hormone-sensitive lipase testicular isoform, lipase, hormone-sensitive
Species: human

Top Publications

  1. doi Transcription of LIPE gene encoding hormone-sensitive lipase/cholesteryl esterase is regulated by SF-1 in human adrenocortical cells: involvement of protein kinase A signal transduction pathway
    M Hołlysz
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 Swiecickiego St, 60 781 Poznan, Poland
    J Mol Endocrinol 46:29-36. 2011
  2. ncbi Hormone sensitive lipase mRNA in both monocyte and macrophage forms of the human THP-1 cell line
    W J Johnson
    Abramson Research Center, Joseph Stokes, Jr, Research Institute, Children s Hospital of Philadelphia, PA 19104, USA
    Comp Biochem Physiol B Biochem Mol Biol 126:543-52. 2000
  3. ncbi Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression
    Marie L S Lindegaard
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 47:2581-8. 2006
  4. ncbi Mapping of the gene for hormone sensitive lipase (LIPE) to chromosome 19q13.1-->q13.2
    R C Levitt
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore MD, USA
    Cytogenet Cell Genet 69:211-4. 1995
  5. ncbi Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro
    M W Anthonsen
    Department of Cell and Molecular Biology, Section for Molecular Signaling, Lund University, S 221 00 Lund, Sweden
    J Biol Chem 273:215-21. 1998
  6. ncbi Variation in the promoter of the human hormone sensitive lipase gene shows gender specific effects on insulin and lipid levels: results from the Ely study
    P J Talmud
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, The Rayne Institute, London, UK
    Biochim Biophys Acta 1537:239-44. 2001
  7. ncbi Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose
    Fatima Smih
    INSERM Unité 317, Institut Louis Bugnard, Centre Hospitalier Universitaire de Rangueil, Universite Paul Sabatier, Toulouse, France
    Diabetes 51:293-300. 2002
  8. ncbi The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 26:220-7. 2002
  9. pmc Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 547:301-8. 2003
  10. ncbi The presence of a catalytically inactive form of hormone-sensitive lipase is associated with decreased lipolysis in abdominal subcutaneous adipose tissue of obese subjects
    Hind Ray
    Institut National de la Santé et de la Recherche Medicale INSERM 499, Faculte de Medecine Laennec, Rue Paradin, 69372 Lyon, France
    Diabetes 52:1417-22. 2003

Research Grants

  1. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
  2. Jun Liu; Fiscal Year: 2014
  3. Zhanxiang Zhou; Fiscal Year: 2016
  4. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
  5. Dawn L Brasaemle; Fiscal Year: 2014
  6. Enrique Saez; Fiscal Year: 2014
  7. Perilipiin and Lipolysis
    Andrew Greenberg; Fiscal Year: 2007
  8. ADIPOSE DISTRIBUTION AND ADRENERGIC MECHANISMS IN AGING
    Robert Schwartz; Fiscal Year: 1993
  9. POLYMORPHISMS OF B1 AND B2 RECEPTOR GENES AND OBESITY
    John Lima; Fiscal Year: 2002
  10. OBESITY, EXERCISE, & FAT CELL METABOLISM IN OLDER WOMEN
    Barbara Nicklas; Fiscal Year: 2000

Detail Information

Publications249 found, 100 shown here

  1. doi Transcription of LIPE gene encoding hormone-sensitive lipase/cholesteryl esterase is regulated by SF-1 in human adrenocortical cells: involvement of protein kinase A signal transduction pathway
    M Hołlysz
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 Swiecickiego St, 60 781 Poznan, Poland
    J Mol Endocrinol 46:29-36. 2011
    ..transduction pathway on transcription of the LIPE gene encoding hormone-sensitive lipase/cholesteryl esterase (HSL) in H295R cells...
  2. ncbi Hormone sensitive lipase mRNA in both monocyte and macrophage forms of the human THP-1 cell line
    W J Johnson
    Abramson Research Center, Joseph Stokes, Jr, Research Institute, Children s Hospital of Philadelphia, PA 19104, USA
    Comp Biochem Physiol B Biochem Mol Biol 126:543-52. 2000
    ..Prior studies indicate that hormone sensitive lipase (HSL) is a major CEH in mouse macrophages, and that HSL mRNA is present in human THP-1 monocytes...
  3. ncbi Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression
    Marie L S Lindegaard
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Lipid Res 47:2581-8. 2006
    ..triglyceride (TG) concentration and mRNA expression of endothelial lipase (EL) and hormone-sensitive lipase (HSL) were increased in placentas from women with diabetes...
  4. ncbi Mapping of the gene for hormone sensitive lipase (LIPE) to chromosome 19q13.1-->q13.2
    R C Levitt
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore MD, USA
    Cytogenet Cell Genet 69:211-4. 1995
    Free fatty acids are the major source of fuel for mammals, and hormone sensitive lipase (LIPE) plays a critical role in lipid metabolism by mobilizing free fatty acids from stored triglycerides...
  5. ncbi Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro
    M W Anthonsen
    Department of Cell and Molecular Biology, Section for Molecular Signaling, Lund University, S 221 00 Lund, Sweden
    J Biol Chem 273:215-21. 1998
    Hormone-sensitive lipase (HSL) is the rate-limiting enzyme in lipolysis. Stimulation of rat adipocytes with isoproterenol results in phosphorylation of HSL and a 50-fold increase in the rate of lipolysis...
  6. ncbi Variation in the promoter of the human hormone sensitive lipase gene shows gender specific effects on insulin and lipid levels: results from the Ely study
    P J Talmud
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, The Rayne Institute, London, UK
    Biochim Biophys Acta 1537:239-44. 2001
    We previously identified a hormone sensitive lipase (HSL) promoter variant, -60C>G, which in vitro exhibits 40% reduced promoter activity...
  7. ncbi Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose
    Fatima Smih
    INSERM Unité 317, Institut Louis Bugnard, Centre Hospitalier Universitaire de Rangueil, Universite Paul Sabatier, Toulouse, France
    Diabetes 51:293-300. 2002
    Hormone-sensitive lipase (HSL) catalyzes the rate-limiting step in the mobilization of fatty acids from adipose tissue, thus determining the supply of energy substrates in the body...
  8. ncbi The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study
    C Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 26:220-7. 2002
    ....
  9. pmc Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 547:301-8. 2003
    It has been proposed that hormone-sensitive lipase (HSL) regulates intramuscular triacylglycerol hydrolysis in skeletal muscle...
  10. ncbi The presence of a catalytically inactive form of hormone-sensitive lipase is associated with decreased lipolysis in abdominal subcutaneous adipose tissue of obese subjects
    Hind Ray
    Institut National de la Santé et de la Recherche Medicale INSERM 499, Faculte de Medecine Laennec, Rue Paradin, 69372 Lyon, France
    Diabetes 52:1417-22. 2003
    Hormone-sensitive lipase (HSL)-L is a key enzyme in the mobilization of fatty acids from triglyceride stores in adipocytes. A shorter variant of HSL (HSL-S) was detected in humans...
  11. ncbi Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes
    Chun li Su
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 8028, USA
    J Biol Chem 278:43615-9. 2003
    ..This reaction is mediated by hormone-sensitive lipase (HSL), a cytosolic enzyme, and perilipin, which coats the lipid droplet surface in adipocytes...
  12. ncbi Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
    C Holm
    Department of Cell and Molecular Biology, Section for Molecular Signalling, Lund University, Lund, Sweden
    Biochem Soc Trans 31:1120-4. 2003
    b>HSL (hormone-sensitive lipase) is a key enzyme in the mobilization of fatty acids from acylglycerols in adipocytes as well as non-adipocytes...
  13. ncbi Genetic variation at the hormone sensitive lipase: gender-specific association with plasma lipid and glucose concentrations
    L Qi
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Genet 65:93-100. 2004
    Hormone-sensitive lipase (HSL) catalyzes the intracellular hydrolysis of triacylglycerols and cholesteryl esters, and it is involved in regulating body fat, steroidogenesis, and insulin secretion...
  14. ncbi Might the kinetic behavior of hormone-sensitive lipase reflect the absence of the lid domain?
    Yassine Ben Ali
    Enzymology at Interfaces and Physiology of Lipolysis, UPR 9025 CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Biochemistry 43:9298-306. 2004
    Hormone-sensitive lipase (HSL) is thought to contribute importantly to the mobilization of fatty acids from the triacylglycerols (TAGs) stored in adipocytes, providing the main source of energy in mammals...
  15. pmc Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 560:551-62. 2004
    Hormone-sensitive lipase (HSL) catalyses the hydrolysis of myocellular triacylglycerol (MCTG), which is a potential energy source during exercise...
  16. ncbi Mutational analysis of the "regulatory module" of hormone-sensitive lipase
    Jining Wang
    VA Palo Alto Health Care System, Palo Alto, California, USA
    Biochemistry 44:1953-9. 2005
    Hormone-sensitive lipase (HSL) is a rate-limiting enzyme in lipolysis that displays broad substrate specificity. HSL function is regulated by reversible phosphorylation that occurs within a 150 aa "regulatory module" of the protein...
  17. ncbi The hormone-sensitive lipase C-60G promoter polymorphism is associated with increased waist circumference in normal-weight subjects
    E Carlsson
    Department of Clinical Sciences, Diabetes and Endocrinology, Malmo University Hospital, Lund University, Sweden
    Int J Obes (Lond) 30:1442-8. 2006
    Hormone-sensitive lipase (HSL) is a key enzyme in the mobilization of fatty acids from triglyceride stores in adipocytes...
  18. ncbi Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 291:R1094-9. 2006
    Skeletal muscle hormone-sensitive lipase (HSL) activity is increased by contractions and increases in blood epinephrine (EPI) concentrations and cyclic AMP activation of the adrenergic pathway during prolonged exercise...
  19. ncbi Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity
    A Mairal
    INSERM, U586, Obesity Research Unit, Toulouse, France
    Diabetologia 49:1629-36. 2006
    ..phospholipase domain containing 2 [PNPLA2]), gene product of Pnpla2, has questioned the unique role of hormone sensitive lipase (HSL, now known as LIPE), gene product of Lipe, in fat cell lipolysis...
  20. ncbi Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 291:E1106-14. 2006
    ..To investigate whether this could be due to sex-specific regulation of hormone-sensitive lipase (HSL) and to use sex comparison as a model to gain further insight into HSL regulation, nine women and eight men ..
  21. ncbi Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 281:40236-41. 2006
    ..In this study, we demonstrate that adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major enzymes contributing to TG breakdown in in vitro assays and in organ cultures of murine white ..
  22. ncbi Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state
    Johan W E Jocken
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    J Clin Endocrinol Metab 92:2292-9. 2007
    ..The mobilization of stored TAG is mediated by hormone-sensitive lipase (HSL) and the recently discovered adipose triglyceride lipase (ATGL)...
  23. pmc Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation
    Johan W E Jocken
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Diabetes 57:1834-41. 2008
    ..We aimed to investigate whether a blunted fasting or beta-adrenergically mediated lipolysis contributes to this increased IMTG storage in obesity...
  24. doi Cloning and functional characterization of the 5' regulatory region of ovine Hormone Sensitive Lipase (HSL) gene
    Antonis D Lampidonis
    Department of Animal Science, Laboratory of Animal Breeding and Husbandry, Agricultural University of Athens, Iera Odos 75, 118 55 Athens, Greece
    Gene 427:65-79. 2008
    b>Hormone Sensitive Lipase (HSL) catalyzes the rate-limiting step in the mobilization of fatty acids from adipose tissue, thus determining the supply of energy substrates in the body...
  25. pmc LIPE C-60G influences the effects of physical activity on body fat and plasma lipid concentrations: the Quebec Family Study
    Christophe Garenc
    Departement de Medecine, Universite Laval, QC, Canada
    Hum Genomics 3:157-68. 2009
    ....
  26. ncbi Association of the hormone sensitive lipase -60C > G variant with fasting insulin levels in healthy young men
    P J Talmud
    Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, London, UK
    Nutr Metab Cardiovasc Dis 12:173-7. 2002
    b>Hormone sensitive lipase (HSL) is the rate-limiting enzyme in triglyceride intracellular lipolysis, generating free fatty acids for energy utilisation...
  27. doi Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK
    Mandeep P Gaidhu
    Muscle Health Research Centre, York Univ, 4700 Keele St, Toronto, ON, Canada M3J 1P3
    Am J Physiol Cell Physiol 298:C961-71. 2010
    ..lipase (ATGL) content and comparative gene identification-58 (CGI-58) expression, whereas hormone-sensitive lipase (HSL) phosphorylation and perilipin content were severely reduced...
  28. ncbi [The mechanisms of stimulated lipolysis by high concentration of glucose in primary rat adipocytes]
    Ting Ting Zhang
    Department of Endocrinology, Peking University First Hospital, Beijing, China
    Beijing Da Xue Xue Bao 40:273-9. 2008
    ..To investigate the cellular mechanisms of adipocyte lipolytic response to a high concentration of glucose, which liberates free fatty acids (FFA) efflux from adipose cells to plasma...
  29. pmc Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins
    Hong Wang
    Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Health Care Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 284:32116-25. 2009
    ..adipose differentiation-related protein (ADFP), and LSDP5, control lipolysis catalyzed by hormone-sensitive lipase (HSL), a major lipase in adipocytes and several non-adipose cells...
  30. ncbi Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1
    Marie Line Peyot
    Molecular Nutrition Unit, Department of Nutrition, University of Montréal and the Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    Diabetes 53:1733-42. 2004
    We previously reported decreased glucose-stimulated insulin secretion (GSIS) in hormone-sensitive lipase-null mice (HSL(-/-)), both in vivo and in vitro...
  31. ncbi Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms
    Hideaki Miyoshi
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 281:15837-44. 2006
    Hormone-sensitive lipase (HSL) is the predominant lipase effector of catecholamine-stimulated lipolysis in adipocytes...
  32. ncbi The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice
    S P Wang
    Department of Pediatrics, Research Center, Sainte Justine Hospital, Montreal, Quebec, Canada
    Obes Res 9:119-28. 2001
    To directly ascertain the physiological roles in adipocytes of hormone-sensitive lipase (HSL; E.C. 3.1.1.3), a multifunctional hydrolase that can mediate triacylglycerol cleavage in adipocytes.
  33. pmc Quantification of hormone sensitive lipase phosphorylation and colocalization with lipid droplets in murine 3T3L1 and human subcutaneous adipocytes via automated digital microscopy and high-content analysis
    Patrick M McDonough
    Vala Sciences, Inc, San Diego, California, USA
    Assay Drug Dev Technol 9:262-80. 2011
    Lipolysis in adipocytes is associated with phosphorylation of hormone sensitive lipase (HSL) and translocation of HSL to lipid droplets...
  34. ncbi Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis
    Hui H Zhang
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 278:51535-42. 2003
    ..as an enhancer of cyclic AMP-dependent protein kinase (PKA)-stimulated lipolysis by both hormone-sensitive lipase (HSL) and non-HSL(s)...
  35. ncbi Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    Motoyuki Kohjima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 812 8582 Fukuoka, Japan
    Int J Mol Med 20:351-8. 2007
    ..for antioxidant pathways; and diacylglycerol O-acyltransferase 1 (DGAT1), PPARgamma, and hormone-sensitive lipase (HSL) for triglyceride synthesis and catalysis...
  36. pmc Central melanocortin stimulation increases phosphorylated perilipin A and hormone-sensitive lipase in adipose tissues
    Y B Shrestha
    Department of Biology, Georgia State University, Atlanta, Georgia 30302 4010, USA
    Am J Physiol Regul Integr Comp Physiol 299:R140-9. 2010
    ..These results show for the first time in rodents that p-perilipin A can serve as an in vivo, fat pad-specific indictor of lipolysis and extend our previous findings showing that central melanocortin stimulation increases WAT lipolysis...
  37. ncbi Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system
    Sandra C Souza
    Jean Meyer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 277:8267-72. 2002
    ..of cyclic AMP-dependent protein kinase (PKA) results in the phosphorylation of Peri A and hormone-sensitive lipase (HSL), the predominant lipase in adipocytes, with concurrent stimulation of adipocyte lipolysis...
  38. ncbi Glucagon-like peptide-1 and islet lipolysis
    M Sorhede Winzell
    Department of Medicine, Lund University, SE 22184 Lund, Sweden
    Horm Metab Res 36:795-803. 2004
    ..via elevation of cAMP and activation of protein kinase A, which in turn may activate hormone-sensitive lipase (HSL), thereby contributing to fatty acid generation (FFA) from intracellular triglyceride stores...
  39. ncbi Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats
    T Teruel
    Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University, 28040, Madrid, Spain
    Diabetologia 48:1180-8. 2005
    ..genes studied were: (1) lipoprotein lipase (lpl), which is involved in lipid uptake; (2) hormone-sensitive lipase (hsl), which mobilises fatty acids from stored triglycerides; (3) fatty acid synthase (fas), which regulates de novo ..
  40. doi Expression of TGH and its role in porcine primary adipocyte lipolysis
    Li Hong Zhang
    College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi, China
    Mol Cell Biochem 315:159-67. 2008
    ..play a role in lipolysis in porcine primary adipocyte through stimulation by hormones as Hormone-sensitive lipase (HSL)...
  41. pmc Functional interaction of hormone-sensitive lipase and perilipin in lipolysis
    Wen Jun Shen
    Division of Endocrinology, Stanford University, Stanford, California 94305, USA
    J Lipid Res 50:2306-13. 2009
    ..Plin is required for the translocation of hormone-sensitive lipase (HSL) from the cytosol to lipid droplets upon stimulation...
  42. doi The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis
    Antonis D Lampidonis
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Zografou, 157 84 Athens, Greece
    Gene 477:1-11. 2011
    ..Mobilization of adipose tissue fat is mediated by the MGL, HSL and ATGL, similarly functioning enzymes...
  43. ncbi Fatty acid specificity of hormone-sensitive lipase. Implication in the selective hydrolysis of triacylglycerols
    T Raclot
    INSERM Unité 317, Institut Louis Bugnard, Faculte de Medecine, Universite Paul Sabatier, Hopital Rangueil, 31403 Toulouse Cedex 4, France
    J Lipid Res 42:2049-57. 2001
    ..The present study was designed to examine if the release of fatty acids by hormone-sensitive lipase (HSL) in vitro i) is influenced by the amount of unsaturation, ii) depends on the temperature, and iii) could explain ..
  44. ncbi No evidence of linkage between familial combined hyperlipidemia and genes encoding lipolytic enzymes in Finnish families
    P Pajukanta
    National Public Health Institute, Department of Human Molecular Genetics, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 17:841-50. 1997
    ..The lipolytic enzymes lipoprotein lipase (LPL), hepatic lipase (HL), and hormone-sensitive lipase (HSL) were selected as initial candidate genes because of their central roles in apo B and triglyceride metabolism...
  45. ncbi Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase
    Krishnakant G Soni
    Division of Medical Genetics, Ste Justine Hospital, Montreal, Quebec H3T 1C5, Canada
    J Biol Chem 279:40683-9. 2004
    ..Hydrolysis of triglycerides is central to energy homeostasis in white adipose tissue (WAT). Hormone-sensitive lipase (HSL) was previously felt to mediate all lipolysis in WAT...
  46. pmc Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice
    Kristoffer Ström
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    PLoS ONE 3:e1793. 2008
    Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored tri- and diglycerides, thus mobilizing fatty acids...
  47. pmc Hormone-sensitive lipase expression and IHC localization in the rat ovary, oviduct, and uterus
    Maria V T Lobo
    Department of Cell Biology and Genetics, Alcala de Henares University, Madrid, Spain
    J Histochem Cytochem 57:51-60. 2009
    Hormone-sensitive lipase (HSL) is a key regulator of cholesterol esters metabolism. The aim of this study was to determine HSL localization in rat female reproductive organs during the ovarian cycle by IHC methods...
  48. ncbi Infertility and testicular defects in hormone-sensitive lipase-deficient mice
    S Chung
    Department of Anatomy, McGill University, Montreal, Quebec, Canada
    Endocrinology 142:4272-81. 2001
    ....
  49. ncbi Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, PO Box 71, Bundoora 3083, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E500-8. 2006
    Hormone-sensitive lipase (HSL) is important for the degradation of triacylglycerol in adipose and muscle tissue, but the tissue-specific regulation of this enzyme is not fully understood...
  50. ncbi [Effects of tumor necrosis factor-alpha induced insulin resistance on adipose triglyceride lipase in mice]
    Yu lan Cheng
    Key Laboratory of Laboratory Medical Diagnostics in Ministry of Education, Department of Clinical Biochemistry, Chongqing Medical University, Chongqing 400016, China
    Zhonghua Yi Xue Za Zhi 88:2417-21. 2008
    ..To investigate the effects of tumor necrosis factor (TNF)-alpha induced insulin resistance (IR) on glucose and lipid metabolism and adipose triglyceride lipase (ATGL)...
  51. ncbi Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle
    Guenter Haemmerle
    Institute of Molecular Biology, Biochemistry, and Microbiology, University of Graz, Heinrichstrasse 31A, Graz A 8010, Austria
    J Biol Chem 277:12946-52. 2002
    Hormone-sensitive lipase (HSL) is believed to play an important role in the mobilization of fatty acids from triglycerides (TG), diglycerides, and cholesteryl esters in various tissues...
  52. ncbi The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma
    Ji Young Kim
    Dept of Biochemistry and Cancer Biology, Medical University of Ohio, Toledo, OH 43614, USA
    Am J Physiol Endocrinol Metab 291:E115-27. 2006
    The minimal adipose phenotype of hormone-sensitive lipase (HSL)-null mice suggested that other hormonally responsive lipase(s) were present in adipocytes...
  53. ncbi Hormone-sensitive lipase deficiency in mice causes lipid storage in the adrenal cortex and impaired corticosterone response to corticotropin stimulation
    Hong Li
    Service de Genetique Medicale, Hopital Ste Justine, Montreal, Canada H3T 1C5
    Endocrinology 143:3333-40. 2002
    Hormone-sensitive lipase (HSL, E.C.3.1.1.3, gene designation Lipe) is reportedly the major cholesteryl esterase of adrenal cortex...
  54. pmc Overexpression and properties of a new thermophilic and thermostable esterase from Bacillus acidocaldarius with sequence similarity to hormone-sensitive lipase subfamily
    G Manco
    Istituto di Biochimica delle Proteine ed Enzimologia, CNR, Via Marconi 10, 80125 Naples, Italy
    Biochem J 332:203-12. 1998
    ..corresponds to an open reading frame (ORF3) reported to show homology with the mammalian hormone-sensitive lipase (HSL)-like group of the esterase/lipase family...
  55. ncbi Regulation and role of hormone-sensitive lipase in rat skeletal muscle
    Morten Donsmark
    Copenhagen Muscle Research Centre, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark
    Proc Nutr Soc 63:309-14. 2004
    ..the mobilization of fatty acids from this TG pool may be regulated by the neutral lipase hormone-sensitive lipase (HSL). This enzyme is known to be rate limiting for intracellular TG hydrolysis in adipose tissue...
  56. ncbi Alterations in the testis of hormone sensitive lipase-deficient mice is associated with decreased sperm counts, sperm motility, and fertility
    Louis Hermo
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Mol Reprod Dev 75:565-77. 2008
    Hormone-sensitive lipase (HSL, Lipe, E.C.3.1.1.3) functions as a triglyceride and cholesteryl esterase, supplying fatty acids, and cholesterol to cells...
  57. ncbi Developmental changes of the FAS and HSL mRNA expression and their effects on the content of intramuscular fat in Kazak and Xinjiang sheep
    Yong Qiao
    College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
    J Genet Genomics 34:909-17. 2007
    ..the development-dependent expression levels of fatty acid synthase (FAS) gene and hormone-sensitive lipase (HSL) gene in muscle and their effects on the contents of intramuscular fat (IMF)...
  58. ncbi The translational regulation of lipoprotein lipase by epinephrine involves an RNA binding complex including the catalytic subunit of protein kinase A
    Gouri Ranganathan
    Central Arkansas Veterans Healthcare System, and Department of Medicine, Division of Endocrinology, and the Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 277:43281-7. 2002
    ..These studies demonstrate a dual role for PKA to simultaneously inhibit LPL-mediated lipogenesis through inhibition of LPL translation...
  59. ncbi Reduced atherosclerosis in hormone-sensitive lipase transgenic mice overexpressing cholesterol acceptors
    Henry A Choy
    Lipid Research Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Biochim Biophys Acta 1634:76-85. 2003
    Macrophage-specific overexpression of cholesteryl ester hydrolysis in hormone-sensitive lipase transgenic (HSL Tg) female mice paradoxically increases cholesterol esterification and cholesteryl ester accumulation in macrophages, and thus ..
  60. ncbi Sequence variation and molecular evolution of hormone-sensitive lipase genes in species of bovidae
    Zhijie Ma
    College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China
    J Genet Genomics 34:26-34. 2007
    The partial sequences of exon I of hormone-sensitive lipase (HSL) genes in yak (Bos grunniens), cattle (Bos taurus), zebu (Bos indicus), and buffalo (Bubalus bubalis) were analyzed...
  61. ncbi Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages
    J L Escary
    Lipid Research Laboratory, West Los Angeles VA Medical Center, Los Angeles, CA 90073, USA
    J Lipid Res 40:397-404. 1999
    ..over cholesteryl-ester hydrolysis by a neutral cholesteryl-ester hydrolase, such as hormone-sensitive lipase (HSL), and subsequent cholesterol efflux mediated by extracellular acceptors...
  62. pmc Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity
    J Osuga
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Hongo, Tokyo 113, Japan
    Proc Natl Acad Sci U S A 97:787-92. 2000
    Hormone-sensitive lipase (HSL) is known to mediate the hydrolysis not only of triacylglycerol stored in adipose tissue but also of cholesterol esters in the adrenals, ovaries, testes, and macrophages...
  63. ncbi Phenytoin alters transcript levels of hormone-sensitive lipase in muscle from horses with hyperkalemic periodic paralysis
    M L Yudkowsky
    M S 310, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, 19102 1192, USA
    Arch Biochem Biophys 358:264-70. 1998
    ..The effects of phenytoin treatment on the transcript levels of three key proteins in TAFAM, hormone sensitive lipase (HSL), carnitine palmitoyltransferase (CPT), and fatty acid binding protein (FABP), were examined...
  64. doi Hormone-sensitive lipase is necessary for normal mobilization of lipids during submaximal exercise
    Celine Fernandez
    Department of Experimental Medical Science, Lund University, BMC C11, SE 221 84 Lund, Sweden
    Am J Physiol Endocrinol Metab 295:E179-86. 2008
    ..A key enzyme in the mobilization of fatty acids from intracellular lipid stores is hormone-sensitive lipase (HSL)...
  65. doi Mining the genome sequence for novel enzyme activity: characterisation of an unusual member of the hormone-sensitive lipase family of esterases from the genome of Streptomyces coelicolor A3 (2)
    Sameh H Soror
    LB Genetik, University of Kaiserslautern, Postfach 3049, 67653 Kaiserslautern, Germany
    Protein Eng Des Sel 22:333-9. 2009
    ..that it might differ in substrate specificity from other characterised members of the hormone-sensitive lipase (HSL) family of lipases and esterases...
  66. ncbi Hormone-sensitive lipase is structurally related to acetylcholinesterase, bile salt-stimulated lipase, and several fungal lipases. Building of a three-dimensional model for the catalytic domain of hormone-sensitive lipase
    J A Contreras
    Department of Cell and Molecular Biology, Lund University, Lund S 221 00, Sweden
    J Biol Chem 271:31426-30. 1996
    ....
  67. ncbi Evidence for hormone-sensitive lipase mRNA expression in human monocyte/macrophages
    K Reue
    Lipid Research Laboratory, West Los Angeles VA Medical Center, CA 90073, USA
    Arterioscler Thromb Vasc Biol 17:3428-32. 1997
    The role of hormone-sensitive lipase (HSL) in the hydrolysis of adipose tissue triacylglycerol to provide free fatty acids for energy requirements has been well established...
  68. doi Breed difference and regulation of the porcine adipose triglyceride lipase and hormone sensitive lipase by TNFalpha
    T Shan
    Institute of Feed Science, Zhejiang University, Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou 310029, China
    Anim Genet 40:863-70. 2009
    Adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL) are major novel triglyceride lipases in animals...
  69. ncbi Testis hormone-sensitive lipase expression in spermatids is governed by a short promoter in transgenic mice
    R Blaise
    INSERM Unit 317, Institut Louis Bugnard, Universite Paul Sabatier, Hopital Rangueil, F 31403 Toulouse Cedex 4, France
    J Biol Chem 276:5109-15. 2001
    A testicular form of hormone-sensitive lipase (HSL(tes)), a triacylglycerol lipase, and cholesterol esterase, is expressed in male germ cells. Northern blot analysis showed HSL(tes) mRNA expression in early spermatids...
  70. ncbi Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases
    Henri Chahinian
    Laboratoire d Enzymologie Interfaciale et de Physiologie de la Lipolyse, UPR9025 CNRS, 31 Chemin J Aiguier, 13402 Marseille Cedex 20, France
    Biochim Biophys Acta 1738:29-36. 2005
    ..of hydrolysis of triacylglycerols, vinyl esters and p-nitrophenyl butyrate by four carboxylesterases of the HSL family, namely recombinant human hormone-sensitive lipase (HSL), EST2 from Alicyclobacillus acidocaldarius, AFEST ..
  71. ncbi Depot-specific expression of lipolytic genes in human adipose tissues--association among CES1 expression, triglyceride lipase activity and adiposity
    Shuichi Nagashima
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    J Atheroscler Thromb 18:190-9. 2011
    ....
  72. pmc Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans
    Pierre Marie Badin
    INSERM, U1048, Obesity Research Laboratory, Institute of Metabolicand Cardiovascular Diseases I2MC, Toulouse, France
    Diabetes 60:1734-42. 2011
    ..TAG hydrolysis by adipose triglyceride lipase (ATGL) and are subsequently hydrolyzed by hormone-sensitive lipase (HSL)...
  73. ncbi [Scales for functional assessment in multiple sclerosis]
    J M Prieto-González
    Servicio de Neurologia, Complejo Hospitalario Universitario de Santiago de Compostela, Espana
    Rev Neurol 30:1246-52. 2000
    ..To review the characteristics which should be met by the scales for functional assessment of patients with multiple sclerosis in relation to the degree of invalidity, incapacity and handicap...
  74. doi Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet
    Nora Chen
    Department of Optometry and Vision Sciences, University of Melbourne, Australia
    Nutr Res 29:784-93. 2009
    ..were suppressed by GT (Pref-1, C/EBP-beta, and PPAR-gamma) and BT (C/EBP-beta), while decreasing LPL, HSL, and UCP-2 expression; EGCG increased expression of UCP-2 and PPAR-gamma genes...
  75. doi Epinephrine-mediated regulation of PDK4 mRNA in rat adipose tissue
    Zhongxiao Wan
    Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Cell Physiol 299:C1162-70. 2010
    ..Our results are the very first to demonstrate an epinephrine-mediated regulation of PDK4 mRNA levels in white adipose tissue and suggest that p38 MAPK and PPARγ could be involved in this pathway...
  76. doi 2,5-Piperazinedione inhibits quorum sensing-dependent factor production in Pseudomonas aeruginosa PAO1
    Khadar Syed Musthafa
    Department of Biotechnology, Alagappa University, Karaikudi, Tamil Nadu, India
    J Basic Microbiol 52:679-86. 2012
    ..LasR receptor protein required for binding the natural ligand N -3-oxododecanoyl-l-homoserine lactone (3-oxo-C12-HSL)...
  77. pmc Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism
    Yuanyuan Zhang
    From the Department of Food Science and Nutrition
    J Biol Chem 289:22063-77. 2014
    ..Our findings provide evidence for the novel role Lcn2 plays in oxidative metabolism and BAT activation via an adrenergic independent mechanism. ..
  78. ncbi Sir David Cuthbertson Medal Lecture. Regulation of lipid metabolism in adipose tissue
    J S Samra
    Department of Surgery, Royal North Shore Hospital, St Leonards, NSW, Australia
    Proc Nutr Soc 59:441-6. 2000
    ..In future, it is likely that the mechanisms that lead to the secondary effects of lipid metabolism on atheroma, immunity and carcinogenesis will be demonstrated...
  79. ncbi Molecular and cellular actions of a structural domain of human growth hormone (AOD9401) on lipid metabolism in Zucker fatty rats
    F M Ng
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Monash University, Clayton, Victoria 3168, Australia
    J Mol Endocrinol 25:287-98. 2000
    ..The results suggest that AOD9401 has the potential to be developed into a therapeutic agent for the control of obesity...
  80. ncbi Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro
    Philip G McTernan
    Division of Medical Sciences, Department of Medicine, University of Birmingham and Heartlands Hospital, Edgbaston, Birmingham, UK
    Diabetes 51:1493-8. 2002
    ..Lipolysis and lipogenesis were assessed by protein expression studies of hormone-sensitive lipase (HSL) (84 kDa) and lipoprotein lipase (LPL) (56 kDa), respectively...
  81. ncbi Possible mechanisms by which adipocyte lipolysis is enhanced in exercise-trained rats
    Sachiko Nomura
    Department of Kinesiology, Graduate School of Science, Tokyo Metropolitan University, 1 1 Minami Ohsawa, Hachioji, Tokyo 192 0397, Japan
    Biochem Biophys Res Commun 295:236-42. 2002
    ..Hormone-sensitive lipase (HSL) activities in both fractions were also greater in TR...
  82. ncbi Adequate evaluation of HSL mass and activity in rat adipose tissue in fasting and aging-related obesity
    Takahiro Tsujita
    Central Research Laboratory, School of Medicine, Ehime University, Shigenobu, Onsen gun, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:120-7. 2002
    ..In the present study, the effects of the ways of expressing the hormone sensitive lipase (HSL) activity and content were studied in rat by decreasing or increasing adipose tissue...
  83. ncbi Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid
    Matthew J Watt
    School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, Victoria 3083, Australia
    Am J Physiol Endocrinol Metab 285:E412-9. 2003
    ..of palmitate, the hydrolysis of intramuscular lipids, and the activation of hormone-sensitive lipase (HSL) was examined in isolated rat soleus muscles at rest...
  84. ncbi Contractions induce phosphorylation of the AMPK site Ser565 in hormone-sensitive lipase in muscle
    Morten Donsmark
    Copenhagen Muscle Research Centre, Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark
    Biochem Biophys Res Commun 316:867-71. 2004
    ..Mobilization of fatty acids from this pool is probably regulated by hormone-sensitive lipase (HSL), which has recently been shown to exist in muscle and to be activated by epinephrine via PKA and by contractions ..
  85. pmc N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus
    Saara Qazi
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    Infect Immun 74:910-9. 2006
    ..N-(3-Oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) inhibited the production of exotoxins and cell wall fibronectin-binding proteins but enhanced protein A expression...
  86. ncbi [Effect of Leonurus Heterophyllus Sweet on tissue factor transcription and expression in human umbilical vein endothelial cells in vitro]
    Lian Zheng
    Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:805-8. 2007
    To investigate the effect of Leonurus Heterophyllus Sweet, (LHS) on tissue factor (TF) transcription and expression induced by thrombin in human umbilical vein endothelial cells (HUVECs).
  87. doi Phosphorylation of perilipin is associated with indicators of lipolysis in Holstein cows
    D A Elkins
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Horm Metab Res 41:736-40. 2009
    ..In the basal state, perilipin inhibits lipolysis by restricting access of hormone sensitive lipase (HSL) to the lipid droplet...
  88. doi Inhibition by chestnut honey of N-Acyl-L-homoserine lactones and biofilm formation in Erwinia carotovora, Yersinia enterocolitica, and Aeromonas hydrophila
    Pilar Truchado
    Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS CSIC, Espinardo, Murcia 30100, Spain
    J Agric Food Chem 57:11186-93. 2009
    ..of culture supernatants confirmed the presence of three main AHLs: N-(3-oxohexanoyl)-L-homoserine lactone (3-oxo-C6-HSL) and N-hexanoyl-L-homoserine lactone (C6-HSL) in E. carotovora and Y...
  89. doi Genetic variation at the goat hormone-sensitive lipase ( LIPE) gene and its association with milk yield and composition
    Ali Zidi
    Departament de Ciencia Animal i dels Aliments, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    J Dairy Res 77:190-8. 2010
    ..0032) as well as on C18:3 n-6g (P=0.0051), trans-10 cis-12 CLA (P=0.007) and C12:0 (P=0.0084) milk contents. These associations are concordant with the preference of LIPE to selectively mobilize medium-chain and unsaturated fatty acids...
  90. doi Role of beta1-adrenoceptor in increased lipolysis in cancer cachexia
    Dong xing Cao
    Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
    Cancer Sci 101:1639-45. 2010
    Increased production of hormone-sensitive lipase (HSL) protein has been demonstrated to be the major cause behind enhanced lipolysis in cancer cachexia. The mechanism governing this alteration is unknown and was presently investigated...
  91. pmc B56alpha/protein phosphatase 2A inhibits adipose lipolysis in high-fat diet-induced obese mice
    Brice P Kinney
    Department of Pediatrics, University of California San Diego, La Jolla, California 92093, USA
    Endocrinology 151:3624-32. 2010
    ..The levels of Ser660 phosphorylation of hormone-sensitive lipase (HSL) were significantly decreased in the epididymal fat of DIO mice...
  92. pmc Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway
    Sarah M Choi
    Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell Biol 30:5009-20. 2010
    ..In contrast, the phosphorylation of another PKA substrate, hormone-sensitive lipase (HSL), remains Akt dependent. Furthermore, insulin regulates total PKA activity in an Akt-dependent manner...
  93. doi Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liver
    Nicole G Ashino
    Universidade Braz Cubas, CEP 08 773 380, Mogi das Cruzes, Sao Paulo, Brazil
    J Nutr Biochem 23:341-8. 2012
    ..It is interesting that all changes observed were independent of postweaning diet in 14-week-old offspring. Therefore, these data further reinforce the importance of maternal nutrition to adult offspring health...
  94. pmc Fish oil -- how does it reduce plasma triglycerides?
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, SD, USA
    Biochim Biophys Acta 1821:843-51. 2012
    ..The key regulator of plasma NEFA is intracellular adipocyte lipolysis via hormone sensitive lipase (HSL), which increases as insulin sensitivity worsens...
  95. pmc Modulation of translation and induction of autophagy by bacterial exoproducts
    Gisela von Hoven
    Institute of Medical Microbiology and Hygiene, University Medical Center, Johannes Gutenberg University Mainz, Hochhaus am Augustusplatz, 55131 Mainz, Germany
    Med Microbiol Immunol 201:409-18. 2012
    ..a small pore-forming toxin (PFT) of Staphylococcus aureus and (S)-3-oxo-C12-homoserine lactone [(S)-3-oxo-C12-HSL], a quorum-sensing hormone of Pseudomonas aeruginosa, bacterial exoproducts may also impact translation and ..
  96. pmc Quorum sensing activity of Enterobacter asburiae isolated from lettuce leaves
    Yin Yin Lau
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:14189-99. 2013
    ..asburiae spent supernatant confirmed the production of N-butanoyl homoserine lactone (C4-HSL) and N-hexanoyl homoserine lactone (C6-HSL)...
  97. pmc Clonal growth and plant species abundance
    Tomás Herben
    Institute of Botany, Academy of Science of the Czech Republic, CZ 252 43 Průhonice, Czech Republic Department of Botany, Faculty of Science, Charles University, Benatska 2, CZ 128 01 Praha 2, Czech Republic
    Ann Bot 114:377-88. 2014
    ..The role of clonal growth was compared with the effects of seed reproduction, habitat requirements and growth, proxied both by LHS (leaf-height-seed) traits and by actual performance in the botanical garden.
  98. doi A new role for penicillin acylases: degradation of acyl homoserine lactone quorum sensing signals by Kluyvera citrophila penicillin G acylase
    Ruchira Mukherji
    Division of Biochemical Sciences, CSIR National Chemical Laboratory, Pune 411008, India
    Enzyme Microb Technol 56:1-7. 2014
    ..Kinetic studies performed at pH 8.0 and 50 °C revealed 3-oxo-C6 HSL to be the best substrate for the enzyme with V(max) and K(m) values of 21.37+0.85 mM/h/mg of protein and 0.1+0...
  99. doi Lateral hostilities among nurses employed in intensive care units, emergency departments, operating rooms, and emergency medical services. A national survey in Italy
    Stefano Bambi
    Stefano Bambi, MSN, RN, is a PhD candidate in nursing science at the University of Florence and is from the Emergency and Trauma Intensive Care Unit of Azienda Ospedaliero Universitaria Careggi, Florence, Italy He is a staff nurse in the Emergency and Trauma Intensive Care Unit He was formerly a lecturer in emergency and critical care nursing at University of Florence Italy Giovanni Becattini, MSN, RN, is from the Nursing Executive Floor, USL 7, Siena, Italy He is a nurse manager, and he was formerly a lecturer in emergency and critical care nursing at University of Florence Italy Gian Domenico Giusti, MSN, RN, is from the Intensive Care Unit at Perugia Hospital, Perugia, Italy He is a staff nurse in Intensive Care Unit, and he is currently a lecturer in emergency and critical care nursing at University of Perugia Italy Andrea Mezzetti, MSN, RN, is from the Prehospital Emergency Service at Ospedale San Giuseppe, Empoli, Italy Andrea Guazzini, Psych, is an associate researcher at the Centre for the Study Of Complex Dynamics CSDC, Department of Science of Education and Psychology, at the University of Florence, Italy He also collaborates to nursing studies designs and statistical analysis Enrico Lumini, PhD, MSN, RN, is from University Hospital Integrated Department at Azienda Ospedaliero Universitaria Careggi, Florence, Italy He is currently a lecturer in emergency and critical care nursing at University of Florence Italy
    Dimens Crit Care Nurs 33:347-54. 2014
    Lateral hostilities (LHs) are "nasty, unkind, aggressive behavior between colleagues working at comparable organizational levels." When LHs occur "at least once a week for a period of not less than 6 months," they become "bullying...
  100. doi Effects of dietary supplementation of fulvic acid on lipid metabolism of finishing pigs
    Q Chang
    Institute of Animal Nutrition, Northeast Agricultural University, Mucai Street No 59, Xiangfang District, Harbin 150030, China
    J Anim Sci 92:4921-6. 2014
    ..05). With the raised concentration of dietary fulvic acid, hormone sensitive lipase (HSL) activity was significantly increased (P < 0...
  101. pmc Determinants governing ligand specificity of the Vibrio harveyi LuxN quorum-sensing receptor
    Xiaobo Ke
    Department of Molecular Biology, Princeton University, Princeton, NJ, 08540, USA
    Mol Microbiol 95:127-42. 2015
    ..bacterium Vibrio harveyi exclusively detects the autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone (3OH-C4 HSL) via the two-component receptor LuxN...

Research Grants65

  1. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
    ..or hydrolysis in adipocytes;and b) determining whether GX sPLA2 promotes TAG mobilization by activating hormone sensitive lipase. Results from these studies have the potential to provide important insights into a novel mechanism ..
  2. Jun Liu; Fiscal Year: 2014
    ..and glycerol, has been a subject of intense investigation for decades, with much focus on hormone-sensitive lipase (HSL)...
  3. Zhanxiang Zhou; Fiscal Year: 2016
    ..On the other hand, chronic alcohol exposure activated both hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) pathways in the adipose tissue, indicating an upregulation ..
  4. Ghrelin: Behavioral, Anatomical, and Physiological Components of Obesity
    BRETT JOHN WARREN TEUBNER; Fiscal Year: 2011
    ..of SNS drive) and from WAT, and two SNS-induced intracellular markers of lipolysis (phosphorylation of hormone sensitive lipase and perilipin A) by Western blot...
  5. Dawn L Brasaemle; Fiscal Year: 2014
    ..2, and 3 in the amino terminus of perilipin promotes the docking of PKA-phosphorylated hormone- sensitive lipase (HSL) on lipid droplets through a protein-protein interaction with perilipin, and HSL gains access to TAG and ..
  6. Enrique Saez; Fiscal Year: 2014
    ..Genetic ablation of adipose triglyceride lipase (ATGL) and to a lesser extent hormone sensitive lipase (HSL) can protect from cancer-associated cachexia, demonstrating that correction of the adipocyte ..
  7. Perilipiin and Lipolysis
    Andrew Greenberg; Fiscal Year: 2007
    ..of Perilipin A (Peri A), a lipid droplet- associated phosphoprotein that regulates lipolysis mediated by hormone sensitive lipase (HSL) and non-HSL lipase(s)...
  8. ADIPOSE DISTRIBUTION AND ADRENERGIC MECHANISMS IN AGING
    Robert Schwartz; Fiscal Year: 1993
    ..Beta adrenergic desensitization would reduce hormone sensitive lipase (HSL) mediated lipolysis and possibly increase AT-LPL mediated TG storage (see Appendix, Fig 2) ..
  9. POLYMORPHISMS OF B1 AND B2 RECEPTOR GENES AND OBESITY
    John Lima; Fiscal Year: 2002
    ..The information obtained from our studies are important in designing clinical trials of interventions designed to reduce body weight. ..
  10. OBESITY, EXERCISE, & FAT CELL METABOLISM IN OLDER WOMEN
    Barbara Nicklas; Fiscal Year: 2000
    ..in adipocyte lipolysis related to an increased alpha-2-adrenergic receptor (AR) sensitivity and decreased hormone sensitive lipase (HSL) after WL by increasing beta-AR sensitivity and HSL expression, thus maintaining rates of fat ..
  11. Lipid signal transduction /oscillatory insulin secretion
    BARBARA CORKEY; Fiscal Year: 2004
    ..We further presume that FFA and their release by hormone sensitive lipase (HSL) generate important signals that regulate insulin secretion in response to fuel stimuli and ..
  12. John M Miles; Fiscal Year: 2016
    ..FFAs are released into the blood through the action of hormone sensitive lipase on triglyceride stores in fat cells...
  13. Molecular Signaling of Rapamycin Induced Hyperlipidemia
    GHADA SOLIMAN; Fiscal Year: 2004
    ..be correlated to protein levels and phosphorylation state; phosphatase (PP2A) activities; FFA; TG levels; hormone sensitive lipase (HSL), and lipoprotein lipase (LPL) activities.SPECIFIC AIM 2...
  14. Biological Implications of Tetramic Acid
    Kim D Janda; Fiscal Year: 2010
    ..Two different AHLs, N-(3-oxododecanoyl) homoserine lactone (3-oxo- C12-HSL), synthesized by LasI, and N-butyrylhomoserine lactone (C4-HSL), synthesized by RhlI, have been identified as the ..
  15. MEGESTROL ACETATE FOR TREATMENT OF CANCER CACHEXIA
    David Heber; Fiscal Year: 1992
    ..under controlled conditions to obtain measurements of lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL) catalytic activity, LPL immunoreactive mass, fat cell size, fat cell number and HSL and LPL m-RNA content...
  16. REGULATION OF CHOLESTEROL ESTERASE IN STEROIDOGENESIS
    FREDRIC KRAEMER; Fiscal Year: 1999
    ..CEH) activity purified from the adrenal and the ovary appears to be identical to hormone-sensitive lipase (HSL) purified from adipose tissue...
  17. Retinoid Metabolism in Hepatitic Stellate Cells
    WILLIAM BOSRON; Fiscal Year: 2005
    ..Inhibitors of retinyl ester hydrolysis in stellate cells may be an effective therapeutic strategy for arresting stellate cell activation early in hepatic fibrosis. ..
  18. ADIPOSE METABOLISM IN SUPPORT OF LACTATION
    John McNamara; Fiscal Year: 1992
    ..the beta- adrenergic receptors as well as the intracellular cascade of adenyl cyclase, protein kinase and hormone sensitive lipase and 2) the activity of the sympathetic nervous system partially regulate adipose tissue metabolism in ..
  19. Everett P Greenberg; Fiscal Year: 2016
    ..We will uncouple activation of the quorum regulon, or specific quorum-controlled factors from acyl-HSL signaling, and use our uncoupled mutants in binary culture experiments with parent strains to measure the costs and ..
  20. Paraoxonase-2 S311C Polymorphism Alters Glycosylation and Lactonase Activity
    David A Stoltz; Fiscal Year: 2011
    ..We have recently shown that PON2 inactivates the P. aeruginosa quorum-sensing molecule, 3OC12-HSL and, of clinical interest, a common polymorphism in PON2 (Ser311Cys) impairs this response...
  21. Quorum Sensing in Burkholderia mallei
    Josephine R Chandler; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cell-cell communication by acyl-homoserine lactone (acyl-HSL) quorum sensing (QS) is common to a variety of Gram-negative Proteobacteria and regulates diverse biological functions...
  22. QUORUM SENSING IN HUMAN CELLS
    BRUCE DOLNICK; Fiscal Year: 2002
    ..Signal molecule isolation and characterization. 3) Develop an in vitro assay for acyl-HSL synthesis. Qualification of the role of rTS proteins and other participants in this reaction...
  23. QUORUM SENSING IN HUMAN CELLS
    BRUCE DOLNICK; Fiscal Year: 2003
    ..Signal molecule isolation and characterization. 3) Develop an in vitro assay for acyl-HSL synthesis. Qualification of the role of rTS proteins and other participants in this reaction...
  24. Small Molecule Inhibitor of Quorum Sensing
    Susan Wright; Fiscal Year: 2004
    The opportunistic human pathogen, Pseudomonas aeruginosa, utilizes acyl-homoserine lactones (acyI-HSL) as quorum sensing autoinducers to activate the expression of numerous virulence genes...
  25. rTS Signaling Mimetics As Novel Cancer Therapeutics
    Jie Wang; Fiscal Year: 2006
    ..Dr. Dolnick and his collaborators have since identified an agent (3-oxododecanoyl homoserine lactone, or 3-oxo-C12-HSL, or OHL) that acts through this pathway and enhances the activity of TS inhibitors, in H630 human colorectal cancer ..
  26. IasB is Essential for Surface Motility in P. aeruginosa
    JAYNE ROBINSON; Fiscal Year: 2004
    ..Additionally, lesser amounts of C4-homoserine lactone (HSL) are produced by lasB mutant cells...
  27. WILLIAM DONEGAN; Fiscal Year: 2015
    ..The oromucosal surface is a prominent reservoir for HSV-1 pathogeneses that manifest as herpes simplex labialis (HSL), primary herpetic gingivostomatis, and intraoral vesicles that arise in the hard palate and attached gingival...
  28. Experiences of Family Members of Nursing Home Patients with Advanced Dementia
    Jane L Givens; Fiscal Year: 2013
    ..of the Palliative Care Research Program for Older Adults at Hebrew SeniorLife Institute for Aging Research (HSL IFAR), will serve as the primary sponsor. Dr...
  29. Inexpensive multiplexed ligation probe assay to genotype drug resistant M.tubberc
    HEATHER KOSHINSKY; Fiscal Year: 2012
    ..This will be accomplished in three specific objectives: (1) Design MLPA LHS and RHS probes. (2) Test probe sets. (3) Test on clinical MTB and sputum samples...
  30. DARRELL PORCELLO; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): University of California, Berkeley's Lawrence Hall of Science (LHS), in partnership with the Children's Hospital and Research Center Oakland (CHRCO), proposes to design, develop, implement, ..
  31. Tetrahydrofurans, Tetrahydropyrans and 2H-Furanones
    CHRISTOPHER SPILLING; Fiscal Year: 2009
    ..As inhibitors of HSL, the cyclipostins are lead compounds for the treatment of type II diabetes...
  32. Enhancing the Sustainability of a Pediatric Learning Health System
    Peter A Margolis; Fiscal Year: 2013
    ..these goals and transformed ICN from a clinical improvement collaborative to an operational Learning Health System (LHS) prototype...
  33. NLM Information Resouce Grants to Reduce Health Disparities
    Mary Joan Tooey; Fiscal Year: 2013
    ..Academy (VTTMAA), a magnet high school in Baltimore City, and the Health Sciences and Human Services Library (HS/HSL) at the University of Maryland, Baltimore will prepare potential future health professionals with the skills to ..
  34. Multi-Institutional Pediatric Epilepsy Decision Support
    John P Pestian; Fiscal Year: 2013
    ..This proposal presents how one group, 31 site Childhood Absence Epilepsy Network (CAEN), intends to become an LHS. In this proposal we describe how three sites: Cincinnati Children's Hospital Medical Center, Denver Children&..
  35. TRAINING RURAL HEALTH PROFESSIONALS TO ACCESS NLM DATA
    LESLIE SANDLOW; Fiscal Year: 2002
    ..systems from the University of Illinois College of Medicine, Chicago and Rockford, Library of the Health Sciences (LHS), and universities in downstate Illinois...
  36. Tissue-based validation of COPD Genetic Studies using Lung Health Study Cohort
    Enid Neptune; Fiscal Year: 2009
    ..all known genes on 4,287 European American participants of the multi-center NHLBI-funded Lung Health Study (LHS)...
  37. USING A LOUISIANA NETWORK TO TRAIN/SEARCH NLM DATABASES
    DENNIS PERNOTTO; Fiscal Year: 2001
    ..State University Health Sciences Center-Shreveport (LSUHSC-S) will demonstrate how a Health Sciences Library (HSL) can more effectively extend access to its collections by creatively maximizing the capabilities of existing T1 ..
  38. Vascular and Metabolic Changes in the Diabetic Foot
    Aristidis Veves; Fiscal Year: 2005
    ..rapid acquisition with relaxation enhancement (RARE), and the skin oxygen saturation, using Hyperspectral Imaging (HSl) at the foot level...
  39. Cell-To-Cell Signaling in Bacterial Biofilms
    DAVID CHOPP; Fiscal Year: 2006
    ..The proposed research will develop and utilize mathematical models for predicting acyl-HSL-regulated gene expression in a biofilm system...
  40. LIQUID HANDLING SYSTEM FOR HTP CRYSTALLIZATION
    GEORGE DE TITTA; Fiscal Year: 2003
    ..The requested upgrade is for a key piece of equipment used to set up these experiments: the liquid handling system (LHS)...
  41. Genome-Wide Associations Environmental Interactions in the Lung Health Study
    Kathleen Barnes; Fiscal Year: 2009
    ..The Lung Health Study (LHS), a 14...
  42. Health SmartLibrary
    James Shedlock; Fiscal Year: 2002
    The goal of this project is to develop a Health SmartLibrary (HSL) system prototype that will assist the busy health care professional with selecting and managing electronic information in a way that is useful for them in making clinical ..
  43. Does perinatal exposure to Bisphenol A contribute to adult obesity
    BEVERLY RUBIN; Fiscal Year: 2007
    ..They include C/EBP-alpha, PPAR-gamma, FAS, Glut-4, HSL, and leptin in white adipose tissue, UCP1 in brown adipose tissue, and POMC and NPY in the hypothalamus...
  44. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP DATA COORD CTR
    John Connett; Fiscal Year: 2002
    The Lung Health Study (LHS), conducted from 1986-1994, demonstrated that a smoking intervention program in middle-aged long-term cigarette smokers can result in a highly significant beneficial effect on the rate of FEV1 decline over five ..
  45. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP
    Michael Eichenhorn; Fiscal Year: 2002
    DESCRIPTION: The Lung Health Study (LHS), conducted from 1986-1994, demonstrated that smoking intervention program in middle-aged long-term cigarette smokers can result in a highly significant beneficial effect on the rate of FEV1 ..
  46. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    MURRAY ALTOSE; Fiscal Year: 2002
    The Lung Health Study (LHS), conducted from 1986-1994, demonstrated that a smoking intervention program in middle-aged long-term cigarette smokers can result in a highly significant beneficial effect on the rate of FEV1 decline over five ..
  47. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Nicholas Anthonisen; Fiscal Year: 2002
    The Lung Health Study (LHS), conducted from 1986-1994, demonstrated that a smoking intervention program in middle-aged long-term cigarette smokers can result in a highly significant beneficial effect on the rate of FEV1 decline over five ..
  48. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP
    Paul Scanlon; Fiscal Year: 2002
    The Lung Health Study (LHS), conducted from 1986-1994, demonstrated that a smoking intervention program in middle-aged long-term cigarette smokers can result in a highly significant beneficial effect on the rate of FEV1 decline over five ..
  49. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP
    ALINE BUIST; Fiscal Year: 2002
    The Lung Health Study (LHS), conducted from 1986-1994, demonstrated that a smoking intervention program in middle-aged long-term cigarette smokers can result in a highly significant beneficial effect on the rate of FEV1 decline over five ..
  50. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Robert Wise; Fiscal Year: 2002
    The Lung Health Study (LHS), conducted from 1986-1994, demonstrated that a smoking intervention program in middle-aged long-term cigarette smokers can result in a highly significant beneficial effect on the rate of FEV1 decline over five ..
  51. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP
    Robert Rogers; Fiscal Year: 2002
    The Lung Health Study (LHS), conducted from 1986-1994, demonstrated that a smoking intervention program in middle-aged long-term cigarette smokers can result in a highly significant beneficial effect on the rate of FEV1 decline over five ..
  52. Engaging the Community in Clinical Research
    DORENE MARKEL; Fiscal Year: 2009
    ..Michigan Institute for Clinical and Health Research (MICHR), the University of Michigan Health Sciences Libraries (HSL), and the Ann Arbor District Library (AADL) have combined their strengths in a project that addresses this need for ..
  53. FAMILY HEALTH FOR SCHOOLS AND SCIENCE CENTERS
    KATHARINE BARRETT; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicants abstract): The Lawrence Hall of Science (LHS), a public science and technology center, in collaboration with the School of Public Health, both at the University of California at Berkeley, propose ..
  54. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP
    William Bailey; Fiscal Year: 2002
    The Lung Health Study (LHS), conducted from 1986-1994, demonstrated that a smoking intervention program in middle-aged long-term cigarette smokers can result in a highly significant beneficial effect on the rate of FEV1 decline over five ..
  55. Mechanisms How Adipocytes Affect Bone in Aging Mice
    Fredric B Kraemer; Fiscal Year: 2010
    ....
  56. REGULATION OF HORMONE SENSITIVE LIPASE
    FREDRIC KRAEMER; Fiscal Year: 2003
    ..The critical enzyme which catalyzes this step is thought to be hormone-sensitive lipase (HSL). HSL activity is tightly regulated by hormones and catecholamines to provide appropriate FFA on demand...
  57. ROLE OF A NEW SIGNAL MOLECULE IN P. AERUGINOSA VIRULENCE
    EVERETT PESCI; Fiscal Year: 2004
    ..rhl, to control numerous virulence factors (including LasB elastase) through two primary autoinducers, 3-oxo-C12-HSL and C4-HSL. Recently a third inducer molecule designated as the Pseudomonas Quinolone Signal (PQS) was discovered...
  58. Lipid Droplets: Metabolic Consequences of Stored Neutral Lipids
    Dawn Brasaemle; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. Development automated assay-regulators insulin synthesis
    Patrick McDonough; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  60. Live cell and HCS assays to quantify production of cardiomyocytes from stem cells
    Patrick McDonough; Fiscal Year: 2008
    ..We will develop an instrument that will help researchers produce heart cells from embryonic stem cells. Heart cells produced in this manner can potentially be used to treat heart disease. [unreadable] [unreadable] [unreadable]..
  61. Automated analysis of skeletal muscle fiber crossectional area and metabolic type
    Patrick McDonough; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  62. High Throughput Imaging Assay for Beta-Catenin
    Patrick McDonough; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. HT Image Assay of Lipid Droplet Formation in Human Adipocytes
    Patrick McDonough; Fiscal Year: 2006
    ..intracellular location of lipid-droplet associated proteins such as perilipin, adipophilin, TIP47, and hormone sensitive lipase, which are involved in fat droplet formation and metabolism...