HO-1

Summary

Gene Symbol: HO-1
Description: heme oxygenase 1
Alias: HMOX1D, HO-1, HSP32, bK286B10, heme oxygenase 1, heat shock protein, 32-kD, heme oxygenase (decycling) 1
Species: human

Top Publications

  1. ncbi Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1
    Latesh Lad
    Department of Molecular Biology and Biochemistry, Program in Macromolecular Structure, University of California, Irvine 92697, USA
    J Biol Chem 278:7834-43. 2003
  2. pmc Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
    A Yachie
    Department of Laboratory Sciences, School of Health Sciences, Kanazawa University, Japan
    J Clin Invest 103:129-35. 1999
  3. ncbi The role of heme oxygenase-1 promoter polymorphisms in human disease
    Markus Exner
    Department of Laboratory Medicine, Vienna General Hospital, Medical School, A 1090 Vienna, Austria
    Free Radic Biol Med 37:1097-104. 2004
  4. ncbi Heme oxygenase-1: unleashing the protective properties of heme
    Leo E Otterbein
    Division of Pulmonary and Critical Care Medicine, Montifiore University Hospital, University of Pittsburgh School of Medicine, 3459 5th Avenue, Pittsburgh, PA 15213, USA
    Trends Immunol 24:449-55. 2003
  5. pmc Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart
    Guangwu Wang
    Division of Cardiovascular Medicine, Institute of Molecular Cardiology, Department of Medicine, University of Louisville, ACB, Third Floor, 550 S Jackson St, Louisville, KY 40202, USA
    Circulation 121:1912-25. 2010
  6. ncbi Heme oxygenase-1 induction may explain the antioxidant profile of aspirin
    Nina Grosser
    Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, Wolfgang Langenbeck Str 4, Halle Saale 06099, Germany
    Biochem Biophys Res Commun 308:956-60. 2003
  7. pmc HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage
    Luca Vanella
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA
    Bone 46:236-43. 2010
  8. pmc Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation
    Ignazio Barbagallo
    Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Catania, Italy
    J Bone Miner Metab 28:276-88. 2010
  9. doi Heme oxygenase 1 polymorphisms and plasma concentrations in critically ill patients
    Katri Saukkonen
    Emergency Care, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Shock 34:558-64. 2010
  10. pmc Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum
    Hsuan Wen Hwang
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 284:22672-9. 2009

Research Grants

  1. HemeOxygenase-1 and Transplant Tolerance
    Leo E Otterbein; Fiscal Year: 2011
  2. Donald B Jump; Fiscal Year: 2015
  3. TIFFANY GRAY BAKER; Fiscal Year: 2014
  4. Effect of Heme on mRNA and miRNA Profiles
    Herbert L Bonkovsky; Fiscal Year: 2013
  5. Morris F White; Fiscal Year: 2016
  6. METALS EFFECT ON HEME METABOLISM
    MAHIN MAINES; Fiscal Year: 1999
  7. Heme oxygenase and hemorrhagic circulatory collapse
    Robert Johnson; Fiscal Year: 2007
  8. REGULATION OF HEPATIC HEME METABOLISM
    HERBERT BONKOVSKY; Fiscal Year: 2009
  9. Creatine Transport Across the Blood Brain Barrier
    Joseph Clark; Fiscal Year: 2006
  10. MULTIPLE FORMS OF HEME OXYGENASE--REGULATION BY TOXINS
    MAHIN MAINES; Fiscal Year: 2001

Detail Information

Publications260 found, 100 shown here

  1. ncbi Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1
    Latesh Lad
    Department of Molecular Biology and Biochemistry, Program in Macromolecular Structure, University of California, Irvine 92697, USA
    J Biol Chem 278:7834-43. 2003
    ..It thus appears that the binding of heme and a tightening of the structure around the heme stabilize the solvent H-bonded network required for proper catalysis...
  2. pmc Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
    A Yachie
    Department of Laboratory Sciences, School of Health Sciences, Kanazawa University, Japan
    J Clin Invest 103:129-35. 1999
    ..This study presents not only the first human case of HO-1 deficiency but may also provide clues to the key roles played by this important enzyme in vivo...
  3. ncbi The role of heme oxygenase-1 promoter polymorphisms in human disease
    Markus Exner
    Department of Laboratory Medicine, Vienna General Hospital, Medical School, A 1090 Vienna, Austria
    Free Radic Biol Med 37:1097-104. 2004
    ..In the present article we systematically review the hitherto published evidence that promoter polymorphisms in the HO-1 gene exert functional importance by influencing the level of HO-1 expression in different organ systems...
  4. ncbi Heme oxygenase-1: unleashing the protective properties of heme
    Leo E Otterbein
    Division of Pulmonary and Critical Care Medicine, Montifiore University Hospital, University of Pittsburgh School of Medicine, 3459 5th Avenue, Pittsburgh, PA 15213, USA
    Trends Immunol 24:449-55. 2003
    ..This Review is the third in a series on the regulation of the immune system by metabolic pathways...
  5. pmc Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart
    Guangwu Wang
    Division of Cardiovascular Medicine, Institute of Molecular Cardiology, Department of Medicine, University of Louisville, ACB, Third Floor, 550 S Jackson St, Louisville, KY 40202, USA
    Circulation 121:1912-25. 2010
    ..However, its pathophysiological role in cardiac remodeling and chronic heart failure (HF) is unknown. We hypothesized that induction of HO-1 in HF alleviates pathological remodeling...
  6. ncbi Heme oxygenase-1 induction may explain the antioxidant profile of aspirin
    Nina Grosser
    Department of Pharmacology and Toxicology, School of Pharmacy, Martin Luther University, Wolfgang Langenbeck Str 4, Halle Saale 06099, Germany
    Biochem Biophys Res Commun 308:956-60. 2003
    ..Induction of HO-1 expression and activity may be a novel mechanism by which aspirin prevents cellular injury under inflammatory conditions and in cardiovascular disease...
  7. pmc HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage
    Luca Vanella
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA
    Bone 46:236-43. 2010
    ..Thus, targeting HO-1 expression is a portal to increased osteoblast stem cell differentiation and to the attenuation of osteoporosis by the promotion of bone formation...
  8. pmc Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation
    Ignazio Barbagallo
    Department of Biological Chemistry, Medical Chemistry and Molecular Biology, University of Catania, Catania, Italy
    J Bone Miner Metab 28:276-88. 2010
    ..Thus, the targeting of HO-1 gene expression presents a portal to increase osteoblast function and differentiation and attenuate osteoporosis by promoting bone formation...
  9. doi Heme oxygenase 1 polymorphisms and plasma concentrations in critically ill patients
    Katri Saukkonen
    Emergency Care, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Shock 34:558-64. 2010
    b>Heme oxygenase 1 (HO-1) is a cytoprotective enzyme upregulated by various critical illness-related stress stimuli...
  10. pmc Oligomerization is crucial for the stability and function of heme oxygenase-1 in the endoplasmic reticulum
    Hsuan Wen Hwang
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    J Biol Chem 284:22672-9. 2009
    ..Collectively, these data suggest that oligomerization, driven by TMS-TMS interactions, is crucial for the stabilization and function of HO-1 in the ER...
  11. pmc Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts
    G F Vile
    Swiss Institute for Experimental Cancer Research, ISREC, Lausanne
    Proc Natl Acad Sci U S A 91:2607-10. 1994
    ..ultraviolet A (UVA) radiation has been shown to lead to an increase in levels of the heme catabolizing enzyme heme oxygenase 1 [heme, hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating), EC 1.14.99...
  12. doi Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1
    Takuya Miyazaki
    Department of Internal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Cancer Sci 101:1409-16. 2010
    ..Thus, functional upregulation of Bach1 is a potential strategy for antileukemic therapy...
  13. ncbi Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation
    Miguel P Soares
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 172:3553-63. 2004
    ..This effect of HO-1 is mediated by bilirubin and/or by a decrease of free intracellular Fe2+ but probably not by biliverdin or carbon monoxide...
  14. ncbi Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment
    Pascal O Berberat
    Division of Pancreatic Surgery and Molecular Pancreatic Research, Department of General Surgery, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 11:3790-8. 2005
    ..Therefore, specific inhibition of HO-1 expression may be a new option in pancreatic cancer therapy and may be used as sensitizer to chemotherapy and radiotherapy...
  15. ncbi SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma
    Anders Kallin
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Experimental Medicine Unit, Brussels, Belgium
    J Lipid Res 48:1628-36. 2007
    ..we observed that mature SREBP-1 also induced the expression of genes unrelated to lipid metabolism, such as heme oxygenase 1 (HMOX1), plasma glutathione peroxidase, the phosphatidylinositol-3 kinase regulatory subunit p55 gamma, ..
  16. pmc Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity
    D Nowis
    Department of Immunology, Center of Biostructure Research, The Medical University of Warsaw, Warsaw, Poland
    Oncogene 25:3365-74. 2006
    ..Altogether our results indicate that HO-1 is involved in an important protective mechanism against PDT-mediated phototoxicity and administration of HO-1 inhibitors might be an effective way to potentiate antitumor effectiveness of PDT...
  17. ncbi Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT
    Keith R Brunt
    Department of Physiology, Queen s University, 18 Stuart St, Kingston, Ontario, K7L 4S7 Canada
    Arterioscler Thromb Vasc Biol 26:2027-34. 2006
    ..Recent evidence suggests that PKB/Akt may modulate HO-1 activity. This study examined the role of Akt in mediating the cytoprotective effects of HO-1 in OS-induced apoptosis of human aortic smooth muscle cells (HASMCs)...
  18. doi Genetic analysis of heme oxygenase-1 (HO-1) in German Parkinson's disease patients
    Claudia Funke
    Department of Medical Genetics, Institute of Human Genetics, University of Tuebingen, Calwerstrasse 7, Tuebingen 72076, Germany
    J Neural Transm (Vienna) 116:853-9. 2009
    ..However, our analyses did not reveal a significant association of these genetic markers in the HO-1 gene with an increased susceptibility to PD...
  19. ncbi Crystal structure of human heme oxygenase-1
    D J Schuller
    Departments of Molecular Biology and Biochemistry, and Physiology and Biophysics, and Program in Macromolecular Structure, University of California, Irvine, California 92697 3900, USA
    Nat Struct Biol 6:860-7. 1999
    ..Regioselective oxygenation of the alpha-meso heme carbon is due primarily to steric influence of the distal helix...
  20. ncbi Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor
    Martin Schillinger
    Angiology, Department of Laboratory Medicine, University of Vienna, Medical Faculty, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Am Coll Cardiol 43:950-7. 2004
    ..We investigated the association of the heme oxygenase-1 (HO-1) promoter genotype with the inflammatory response and restenosis after balloon angioplasty...
  21. doi Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK
    D Goven
    INSERM U700, Universite Paris 7, Faculté de Médecine Denis Diderot site Bichat, Paris, France
    FEBS Lett 583:3508-18. 2009
    ..These results suggest that ERK(1/2) and JNK are involved in CS-induced biphasic HO-1 expression by a specific regulation of Nrf2/Keap1-Bach1...
  22. ncbi Heme oxygenase-1: the "emerging molecule" has arrived
    Danielle Morse
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Am J Respir Cell Mol Biol 27:8-16. 2002
    ..This review highlights current information on the function of HO-1 and its relevance to specific pulmonary and cardiovascular diseases...
  23. ncbi Heme oxygenase-1 genotype is a vascular anti-inflammatory factor following balloon angioplasty
    Martin Schillinger
    Department of Angiology, University of Vienna Medical School, Vienna, Austria
    J Endovasc Ther 9:385-94. 2002
    ..To investigate the association of the heme oxygenase-1 (HO-1) genotype, which has potent anti-inflammatory capability, and the inflammatory response induced by balloon angioplasty...
  24. ncbi Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism
    Clinton R Bruce
    Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Diabetes 52:2338-45. 2003
    ..The data provide new evidence that the pathogenesis of type 2 diabetes involves perturbations to the antioxidant defense mechanism within skeletal muscle...
  25. ncbi Heme oxygenase overexpression attenuates glucose-mediated oxidative stress in quiescent cell phase: linking heme to hyperglycemia complications
    David Sacerdoti
    University of Padova, Department of Clinical and Experimental Medicine, Italy
    Curr Neurovasc Res 2:103-11. 2005
    ..These results imply that expression of HO-1 in G0/G1 cells may be a key player in decreasing cellular heme, associated with increased generation of bilirubin, and in attenuating glucose mediated oxidative stress...
  26. ncbi The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting
    Ping Li
    Cardiovascular Department, Second Affiliated Hospital of Jiangxi Medical College, Nanchang 330006, China
    Chin Med J (Engl) 118:1525-32. 2005
    ..The objective of this study was to examine the effect of this variation on the occurrence of restenosis after in-stent treatment in patients with coronary artery disease...
  27. pmc The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E-selectin independently of haem oxygenase-1 expression
    H Song
    Vth Medical Department, University Hospital Mannheim, Mannheim, Germany
    Br J Pharmacol 157:769-80. 2009
    ....
  28. doi Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells
    Geraldine Gueron
    Department of Biological Chemistry, School of Sciences, University of Buenos Aires, Buenos Aires, Argentina
    Mol Cancer Res 7:1745-55. 2009
    ..Inflammation has been recognized as a risk factor for this disease. Heme oxygenase 1 (HO-1), the inducible isoform of the rate-limiting enzyme in heme degradation, counteracts oxidative and ..
  29. pmc Plasma heme oxygenase-1 concentration in relation to impaired glucose regulation in a non-diabetic Chinese population
    Wei Bao
    Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    PLoS ONE 7:e32223. 2012
    ..The current study aimed to examine the association between plasma HO-1 concentration and impaired glucose regulation (IGR) in non-diabetic individuals...
  30. pmc Crystallization of recombinant human heme oxygenase-1
    D J Schuller
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92697 3900, USA
    Protein Sci 7:1836-8. 1998
    ..These crystals belong to space group P2(1), with unit cell dimensions a = 79.3 A, b = 56.3 A, c = 112.8 A, and beta = 101.5 degrees...
  31. ncbi Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate
    Mee Hyang Kweon
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 281:33761-72. 2006
    ..Collectively, our findings suggest that Nrf2-mediated HO-1 overexpression confers resistance to apoptosis induction by EGCG; therefore, its inactivation may be a target for overcoming the resistance to chemoprevention and chemotherapy...
  32. pmc Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes
    Stuart A Rushworth
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, United Kingdom
    J Immunol 181:6730-7. 2008
    ..These results show for the first time that LPS induces NQO1 and HO-1 expression in human monocytes via Nrf2 to modulate their inflammatory responsiveness, thus providing novel potential therapeutic strategies for the treatment of sepsis...
  33. ncbi Heme-induced heme oxygenase-1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation
    Detlef Lang
    Department of Medicine D, University of Muenster, Germany
    Int Immunol 17:155-65. 2005
    ..The fact that HO-1 may adversely affect monocyte survival and differentiation could be of particular significance in future therapies for occlusive vascular diseases or transplant rejection...
  34. pmc Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children
    Maria Rosário Sambo
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    PLoS ONE 5:e11141. 2010
    ..Here, we tested whether those genes were governing the risk of progressing to CM in patients with severe malaria syndromes...
  35. ncbi Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1
    Chikashi Yoshida
    Department of Haematology, Imperial College London, Hammersmith Hospital, UK
    Blood 109:1211-9. 2007
    ....
  36. doi Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress-induced cell death by modulating JNK activation
    Ce Belle Chen
    Division of Cancer and Developmental Cell Biology, Institute of Molecular and Cell Biology, A STAR Agency for Science, Technology and Research, Singapore
    Biosci Rep 29:405-15. 2009
    ..Zinc protoporphyrin IX, a potent inhibitor of HO reversed the H2O2-resistance of shMST3 cells. Our results reveal that H2O2-induced MST3-mediated cell death involves suppressing both a JNK survival pathway and up-regulation of HO-1...
  37. ncbi Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3
    R K Kutty
    Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 20:513-6. 1994
    ..Heme oxygenase-1 (HMOX1), the inducible form, was localized to human chromosome 22q12, while heme oxygenase-2 (HMOX2), the constitutive form, was localized to chromosome 16p13.3...
  38. ncbi Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients
    Ying Hwa Chen
    Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan, Republic of China
    Hum Genet 111:1-8. 2002
    ..Type 2 diabetics carrying longer (GT) (n) repeats might have higher oxidative stress and increased susceptibility to the development of CAD...
  39. ncbi Monocyte NADPH oxidase subunit p22(phox) and inducible hemeoxygenase-1 gene expressions are increased in type II diabetic patients: relationship with oxidative stress
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova, School of Medicine, Italy
    J Clin Endocrinol Metab 88:1753-9. 2003
    ..These findings suggest that these cells, which play a crucial role in the earliest events of atherosclerotic lesion, are subjected to an increased oxidative stress...
  40. ncbi A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease
    Georg Endler
    Clinical Institute for Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School, Vienna Austria
    Thromb Haemost 91:155-61. 2004
    b>Heme oxygenase 1 (HO-1) is involved in the generation of the endogenous anti-oxidant bilirubin which exerts beneficial effects against arteriosclerosis...
  41. ncbi The effect of a promoter polymorphism in the heme oxygenase-1 gene on the risk of ischaemic cerebrovascular events: the influence of other vascular risk factors
    Marion Funk
    Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Vienna, Austria
    Thromb Res 113:217-23. 2004
    ..Short (<25 GT) repeats in the HO-1 gene promoter confer a reduced risk for cerebrovascular events in individuals with normal plasma lipid levels. This may explain controversial findings in different populations...
  42. ncbi Induction of heme oxygenase-1 modulates the profibrotic effects of transforming growth factor-beta in human renal tubular epithelial cells
    A Mark
    Department of Medicine, Nephrology Research and Training Center, University of Alabama, Birmingham, AL 35294 0001, USA
    Cell Mol Biol (Noisy-le-grand) 51:357-62. 2005
    ..These results indicate that HO-1 induction and activity may modulate the production of ECM components and suggest a potential role for TGF-beta-mediated HO-1 induction in attenuating renal fibrosis...
  43. ncbi Haem oxygenase-1 genotype and cardiovascular adverse events in patients with peripheral artery disease
    P Dick
    Department of Angiology, Vienna General Hospital, Medical University Vienna, Austria, Europe
    Eur J Clin Invest 35:731-7. 2005
    ..Short (< 25) (GT)n repeats are suggested to facilitate enhanced HO-1 up-regulation in response to injury and confer potent anti-inflammatory and antioxidative effects...
  44. ncbi Polymorphism of the heme oxygenase-1 gene and cerebral aneurysms
    L Morgan
    Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK
    Br J Neurosurg 19:317-21. 2005
    ..However, because of the relatively small sample size and modest statistical significance, the data must be interpreted with caution and the association needs to be confirmed in further samples...
  45. ncbi Induction of heme oxygenase-1 inhibits monocyte chemoattractant protein-1 mRNA expression in U937 cells
    Tomoki Shokawa
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Pharmacol Sci 100:162-6. 2006
    ..These results suggest that HO-1 may work as an anti-atherogenic agent through the attenuation of MCP-1 production...
  46. ncbi Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis
    Andrei Brydun
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertens Res 30:341-8. 2007
    ..50, p<0.01). In conclusion, the capacity to upregulate HO-1 expression may be determined, at least in part, by genetics, and reduced ability to induce HO-1 may be involved in the mechanism of coronary atherosclerosis...
  47. ncbi Association of functional haem oxygenase-1 gene promoter polymorphism with polycystic kidney disease and IgA nephropathy
    Aisling E Courtney
    Nephrology Research Group, Queen s University Belfast, Belfast, UK
    Nephrol Dial Transplant 23:608-11. 2008
    ..We report the first assessment of the role of this HO-1 gene promoter polymorphism in chronic kidney disease due to autosomal dominant polycystic kidney disease (ADPKD) and IgA nephropathy (IgAN)...
  48. doi Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells
    Jiraporn Kuesap
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 367:413-9. 2008
    ..Thus, PGD(2) may contribute to the maintenance of heme homeostasis in the brain by inducing HO-1 expression...
  49. doi HO-1 underlies resistance of AML cells to TNF-induced apoptosis
    Stuart A Rushworth
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK
    Blood 111:3793-801. 2008
    ..These results demonstrate a novel mechanism by which TNF-induced cell death is inhibited in AML cells through the induction of HO-1, via Nrf2 activation...
  50. doi A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces haem oxygenase-1 expression in human cells through a mechanism independent of hypoxia-inducible factor-1alpha
    Bin Li
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    J Biochem 144:643-54. 2008
    ..In conclusion, the signals evoked by hypoxia and after EDHB treatment differentially regulate HO-1 mRNA expression through HIF-1alpha-independent mechanisms...
  51. doi Increased intestinal expression of heme oxygenase-1 and its localization in patients with ulcerative colitis
    Tomohisa Takagi
    Biomedical Safety Science, Graduate School of Medical Science, Kyoto Prefectual University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    J Gastroenterol Hepatol 23:S229-33. 2008
    ..The aim of the present study was to determine the intestinal levels and localization of ho-1 mRNA and HO-1 protein in patients with UC...
  52. pmc Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (the Ludwigshafen Risk and Cardiovascular Health study)
    Nicola Lüblinghoff
    Department of Otorhinolaryngology Head and Neck Surgery, University Medical Center Freiburg, Freiburg, Germany
    BMC Med Genet 10:36. 2009
    ..We sought to validate these observations in persons scheduled for coronary angiography...
  53. doi A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer
    Moulay A Alaoui-Jamali
    Department of Medicine, Lady Davis Institute of Medical Research, Segal Cancer Centre, McGill University, Montreal, Quebec, Canada
    Cancer Res 69:8017-24. 2009
    ..A potent synergistic activity was observed when OB-24 was combined with Taxol. Together, these results establish HO-1 as a potential therapeutic target for advanced PCA...
  54. ncbi Structural organization of the human heme oxygenase gene and the function of its promoter
    S Shibahara
    Friedrich Miescher Institut, Basel
    Eur J Biochem 179:557-63. 1989
    ..The 5'-flanking region of the human HO gene bearing a potential HSE failed to confer the heat-inducibility of gpt RNA production, suggesting that the HSE of the human HO gene is not functional...
  55. pmc Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite
    S M Keyse
    Swiss Institute for Experimental Cancer Research, Epalinges
    Proc Natl Acad Sci U S A 86:99-103. 1989
    ....
  56. ncbi Human heme oxygenase cDNA and induction of its mRNA by hemin
    T Yoshida
    Friedrich Miescher Institut, Basel, Switzerland
    Eur J Biochem 171:457-61. 1988
    ..In contrast to hemin treatment, heat treatment had no apparent effects in either human cell line on the activity of heme oxygenase and its mRNA levels. These results suggest that human heme oxygenase may not be a heat-shock protein...
  57. ncbi Heme oxygenase-1 protects against vascular constriction and proliferation
    H J Duckers
    Vascular Biology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
    Nat Med 7:693-8. 2001
    ..Induction of the HO-1 pathway moderates the severity of vascular injury by at least two adaptive mechanisms independent of nitric oxide, and is a potential therapeutic target for diseases of the vasculature...
  58. ncbi Interaction of nitric oxide with human heme oxygenase-1
    Jinling Wang
    Department of Pharmaceutical Chemistry, University of California, San Francisco, 94143 0446, USA
    J Biol Chem 278:2341-7. 2003
    ..Inhibition of hHO-1 by NO may contribute to the pleiotropic responses to NO and CO...
  59. ncbi The binding sites on human heme oxygenase-1 for cytochrome p450 reductase and biliverdin reductase
    Jinling Wang
    Department of Pharmaceutical Chemistry, University of California, San Francisco 94143 2280, USA
    J Biol Chem 278:20069-76. 2003
    ..These results confirm the binding of biliverdin reductase to hHO-1 and define binding sites of the two reductases...
  60. ncbi An internal enhancer regulates heme- and cadmium-mediated induction of human heme oxygenase-1
    Nathalie Hill-Kapturczak
    Department of Medicine, Div of Nephrology, Hypertension, and Transplantation, Univ of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 285:F515-23. 2003
    ..Elucidation of the molecular regulation of the human HO-1 gene will allow for the development of therapeutic strategies to manipulate HO-1 gene expression in pathological states...
  61. ncbi Expression pattern and regulation of heme oxygenase-1/heat shock protein 32 in human liver cells
    Inge Bauer
    Department of Anesthesiology, University of the Saarland, D 66421 Homburg, Germany
    Shock 20:116-22. 2003
    ....
  62. ncbi Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein
    Gerhard Kronke
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna A 1090, Austria
    J Biol Chem 278:51006-14. 2003
    ..Induction of HO-1 expression by lipid oxidation products via CREB may represent a feedback mechanism to limit inflammation and associated tissue damage...
  63. ncbi The size of a microsatellite polymorphism of the haem oxygenase 1 gene is associated with idiopathic recurrent miscarriage
    D Denschlag
    Department of Obstetrics and Gynecology, University of Freiburg School of Medicine, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Mol Hum Reprod 10:211-4. 2004
    ..In summary, this is the first report on a HO-1 (GT)(n) microsatellite polymorphism among women with IRM, demonstrating that the investigated polymorphism is associated with IRM in a relatively large Caucasian population...
  64. ncbi A promoter variant of the heme oxygenase-1 gene may reduce the incidence of ischemic heart disease in Japanese
    Koh Ono
    National Cardiovascular Center, Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Atherosclerosis 173:315-9. 2004
    ..The AA genotype of HMOX1 reduced the incidence of ischemic heart disease, possibly due to the high expression level of HMOX1...
  65. ncbi Donor heme oxygenase-1 genotype is associated with renal allograft function
    Markus Exner
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria
    Transplantation 77:538-42. 2004
    ..In the present study we investigated the impact of the promoter polymorphism of kidney allograft donors on clinical outcomes after transplantation...
  66. ncbi Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal pigment epithelial cells
    Reiko Udono-Fujimori
    Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Eur J Biochem 271:3076-84. 2004
    ..These results indicate that RPE cells maintain retinal homeostasis by repressing or inducing the expression of HO-1, depending on the microenvironment...
  67. ncbi Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes
    Nader G Abraham
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 287:H2468-77. 2004
    ..Upregulation of HO-1 decreases oxidant production and endothelial cell damage and shedding and may attenuate vascular complications in diabetes...
  68. ncbi Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection
    Tzong Shyuan Lee
    Division of Biomedical Sciences, University of California, Riverside, CA 92521 0121, USA
    Circulation 110:1296-302. 2004
    ..Here, we studied whether heme oxygenase-1 (HO-1), an important cytoprotective molecule, is induced by simvastatin and the role of HO-1 in the pleiotropic effects of simvastatin...
  69. ncbi Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism
    Akiko Kikuchi
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Hum Genet 116:354-60. 2005
    ..93, 95% CI 0.4-2.0, P=0.85). These findings suggest that the large size of a (GT)(n) repeat in the HO-1 gene promoter may be associated with the development of lung adenocarcinoma in Japanese male smokers...
  70. ncbi Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2
    Anila A Anwar
    Cardiovascular Division, GKT Schools of Biomedical Sciences and Medicine, King s College, University of London, Guy s Hospital Campus, London SE1 1UL, UK
    Free Radic Biol Med 39:227-36. 2005
    ..LDL) play a central role in atherogenesis and induce expression of the antioxidant stress protein heme oxygenase 1 (HO-1)...
  71. ncbi Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells
    Richard M Ogborne
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, CB1 9NL, UK
    Arterioscler Thromb Vasc Biol 25:2100-5. 2005
    ..This study examined the effects of ALA on HO-1 expression in human monocytic cells...
  72. ncbi Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption
    Jochen Zwerina
    Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    FASEB J 19:2011-3. 2005
    b>Heme oxygenase 1 (HO-1) plays an important role in vascular disease, transplantation, and inflammation. In animal models of acute and chronic inflammation, induction of HO-1 has anti-inflammatory and cytoprotective properties...
  73. ncbi Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar
    Masato Takeda
    Department of Medical Zoology, Saitama Medical School, Saitama 350 0495, Japan
    Jpn J Infect Dis 58:268-71. 2005
    ..The frequency of homozygotes for the short (GT)n alleles (<28 repeats) in CM patients was significantly higher than those in UM patients (P < 0.008, OR = 3.14). Thus, short (GT)n alleles represent a genetic risk factor for CM...
  74. ncbi HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells
    Tahereh Ghaziani
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1111, USA
    J Hepatol 45:5-12. 2006
    ..Other recent work has implicated Bach1, a heme binding protein that represses gene expression, in the regulation of HO-1 gene expression...
  75. pmc Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphism
    H Yasuda
    J Med Genet 43:e17. 2006
    ....
  76. ncbi Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway
    Jérôme Busserolles
    Department of Pharmacology, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjasot, Valencia, Spain
    Int J Biochem Cell Biol 38:1510-7. 2006
    ..We have extended these observations by demonstrating that these effects are independent of p38 but are mediated via Akt pathway...
  77. pmc Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
    Warren J Huber
    Department of Pharmacology and Experimental Therapeutics and The Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, Louisiana 70112, USA
    Biochemistry 46:12212-9. 2007
    ....
  78. pmc Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Gastroenterology 133:1166-74. 2007
    ..This study was to assess whether a specific miR-122 antagomir down-regulates HCV protein replication and up-regulates HO-1...
  79. pmc (GT)N dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course
    M Hausmann
    Department of Internal Medicine I, University of Regensburg, Germany
    Clin Exp Immunol 153:81-5. 2008
    ..Our data indicate that (GT)(n) dinucleotide repeats of the HO-1 promotor region have no significance for the pathophysiology and disease course of IBD...
  80. doi Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9
    Cheng Wei Lin
    Graduate Institute of Pharmacy, School of Pharmacy, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan, Republic of China
    Mol Cancer Ther 7:1195-206. 2008
    In the present study, we investigated the antitumor effects of the invasiveness and migration of heme oxygenase 1 (HO-1) in human breast carcinoma cells...
  81. doi Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk
    Yulin Li
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:777-84. 2009
    ..77, 95% CI = 1.05-2.99, P-interaction = 0.006). Our results support the hypothesis that there are joint effects of endogenous and exogenous antioxidants...
  82. doi Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque
    Caroline Cheng
    Molecular Cardiology Laboratory, Experimental Cardiology, Thoraxcenter, Erasmus University Medical Center Rotterdam, Rotterdam 3015 CE, The Netherlands
    Circulation 119:3017-27. 2009
    The molecular regulation for the transition from stable to vulnerable plaque remains to be elucidated. Heme oxygenase 1 (HO-1) and its metabolites have been implicated in the cytoprotective defense against oxidative injury in ..
  83. pmc Hypochlorous acid-induced heme oxygenase-1 gene expression promotes human endothelial cell survival
    Yong Wei
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri 65212, USA
    Am J Physiol Cell Physiol 297:C907-15. 2009
    ..The ability of HOCl to activate HO-1 gene expression may represent a critical adaptive response to maintain endothelial cell viability at sites of vascular inflammation and atherosclerosis...
  84. doi Serum heme oxygenase-1 levels are increased in Parkinson's disease but not in Alzheimer's disease
    I Mateo
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Marqués de Valdecilla University Hospital University of Cantabria, Santander, Spain
    Acta Neurol Scand 121:136-8. 2010
    ..The role of HO-1 in peripheral blood of PD and AD patients remains unresolved...
  85. doi Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis
    Wei Bao
    Department of Nutrition and Food Hygiene and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Am J Epidemiol 172:631-6. 2010
    ..25, 95% confidence interval: 1.04, 1.50; P = 0.02). Persons carrying longer (GT)(n) repeats in the HMOX1 gene promoter may have a higher risk of type 2 diabetes...
  86. pmc Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus
    Wei Bao
    Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    PLoS ONE 5:e12371. 2010
    ..However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM)...
  87. doi Heme oxygenase-1 polymorphism is not associated with risk of colorectal cancer: a Danish prospective study
    Vibeke Andersen
    Medical Department, Viborg Regional Hospital, Denmark
    Eur J Gastroenterol Hepatol 23:282-5. 2011
    ..Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis...
  88. doi Haem oxygenase-1: non-canonical roles in physiology and pathology
    Anna Grochot-Przeczek
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Clin Sci (Lond) 122:93-103. 2012
    ....
  89. pmc Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis
    Klaudia Skrzypek
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 19:644-60. 2013
    ..Here, we investigated whether HMOX1 can modulate microRNAs (miRNAs) and regulate human non-small cell lung carcinoma (NSCLC) development...
  90. pmc Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells
    Wei Hong Hou
    Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, United States
    World J Gastroenterol 15:4499-510. 2009
    ..To investigate effects of iron on oxidative stress, heme oxygenase-1 (HMOX1) and hepatitis C viral (HCV) expression in human hepatoma cells stably expressing HCV proteins...
  91. pmc Hypochlorite-modified high-density lipoprotein promotes induction of HO-1 in endothelial cells via activation of p42/44 MAPK and zinc finger transcription factor Egr-1
    Christine Rossmann
    Center for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria
    Arch Biochem Biophys 509:16-25. 2011
    ..The present study demonstrates a novel compensatory pathway against adverse effects of HOCl-HDL, providing cytoprotection in a number of pathological conditions including cardiovascular disease...
  92. ncbi Differential effect of heme oxygenase-1 in endothelial and smooth muscle cell cycle progression
    Giovanni Li Volti
    Department of Medicine, New York Medical College, 10595, Valhalla, NY, USA
    Biochem Biophys Res Commun 296:1077-82. 2002
    ..Nevertheless, these findings suggest that cell-specific targeting of HO-1 expression may provide a novel therapeutic strategy for the treatment of cardiovascular diseases...
  93. pmc The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality
    Ho Jun Chin
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    J Korean Med Sci 24:S30-7. 2009
    ..060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients...
  94. pmc Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules
    Pallavi Banerjee
    Division of Nephrology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 287:32113-23. 2012
    ..Thus, application of chemotherapeutic drugs along with HO-1 inhibitor may elevate therapeutic efficiency by reducing the cytoprotective effects of HO-1 and by simultaneous induction of both apoptosis and autophagy...
  95. ncbi Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution
    M D Maines
    Department of Biophysics, University of Rochester School of Medicine, NY 14642, USA
    Urology 47:727-33. 1996
    ..The aim of this study was to examine the pattern of tissue expression of HO-1 in the human prostate under different states of proliferation and differentiation and to investigate whether the pattern differs between these states...
  96. pmc Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema
    N Yamada
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Am J Hum Genet 66:187-95. 2000
    ..These findings suggest that the large size of a (GT)n repeat in the HO-1 gene promoter may reduce HO-1 inducibility by reactive oxygen species in cigarette smoke, thereby resulting in the development of CPE...
  97. ncbi Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty
    M Exner
    Department of Laboratory Medicine, University of Vienna Medical School, Austria
    J Endovasc Ther 8:433-40. 2001
    ..A dinucleotide repeat in the promoter region of the HO-1 gene shows a length polymorphism that modulates the level of gene transcription...
  98. ncbi A significant role for the heme oxygenase-1 gene in endothelial cell cycle progression
    Taketoshi Kushida
    Department of Medicine and Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Biochem Biophys Res Commun 291:68-75. 2002
    ....
  99. ncbi Pro-oxidant and cytotoxic effects of circulating heme
    Viktoria Jeney
    Department of Medicine, University of Debrecen, Hungary
    Blood 100:879-87. 2002
    ....
  100. ncbi Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6 Canada
    Am J Respir Crit Care Med 166:323-8. 2002
    ..20; p = 0.01). However, due to the multiple comparisons that were made, these associations may represent type 1 error. There was no association between HMOX1 (GT)n alleles and the rate of decline in lung function in smokers...
  101. ncbi Heme oxygenase-1 gene promoter polymorphism is associated with abdominal aortic aneurysm
    Martin Schillinger
    Division of Angiology, Department of Internal Medicine II, University of Vienna, Medical School, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Thromb Res 106:131-6. 2002
    ..We hypothesised that patients with AAA had less frequently short repeats in the HO-1 gene promoter compared to patients with coronary (CAD) or peripheral artery disease (PAD), or healthy controls...

Research Grants38

  1. HemeOxygenase-1 and Transplant Tolerance
    Leo E Otterbein; Fiscal Year: 2011
    ..This would hopefully allow the combined use of CO or biliverdin with DST or some other tolerance-inducing regimen to develop a pre-clinical protocol. ..
  2. Donald B Jump; Fiscal Year: 2015
    ..Defining the mechanistic linkage between PUFA synthesis, TAG hydrolysis, FoxO1, GNG &stress pathways will identify novel methods to manage diabetic complications, like hyperglycemia &fatty liver. ..
  3. TIFFANY GRAY BAKER; Fiscal Year: 2014
    ..One of these Hsps, Hsp32, has been shown to inhibit cisplatin-induced hair cell death in neonatal rat cochlea in vitro (Kim et al. 2006)...
  4. Effect of Heme on mRNA and miRNA Profiles
    Herbert L Bonkovsky; Fiscal Year: 2013
    ..Genes and their products of particular importance in heme metabolism are ALA synthase 1 [ALAS1] and heme oxygenase 1 [HMOX1], respectively, the rate-controlling enzymes of heme synthesis and catabolism...
  5. Morris F White; Fiscal Year: 2016
    ....
  6. METALS EFFECT ON HEME METABOLISM
    MAHIN MAINES; Fiscal Year: 1999
    ..identified as a metal-inducible protein nearly 2 decades ago, is now recognized as a stress or heat shock protein (HSP32) and is inducible by oxidative stress, toxic heavy metals and environmental agents...
  7. Heme oxygenase and hemorrhagic circulatory collapse
    Robert Johnson; Fiscal Year: 2007
    ..An inducible isoform of heme oxygenase (HO) is a well established "heat shock protein" (HSP32, HO-1) which catalyzes the conversion of heme to biliverdin, free iron and CO...
  8. REGULATION OF HEPATIC HEME METABOLISM
    HERBERT BONKOVSKY; Fiscal Year: 2009
    ..the molecular mechanisms that mediate heme regulation of ALAS-1 and HO-1 are similar in avian, human, and murine hepatocytes in culture or in intact organisms. ..
  9. Creatine Transport Across the Blood Brain Barrier
    Joseph Clark; Fiscal Year: 2006
    ..The goal for Hypothesis 2 is to develop methods and drugs to improve brain energy metabolism by getting creatine into the brain. ..
  10. MULTIPLE FORMS OF HEME OXYGENASE--REGULATION BY TOXINS
    MAHIN MAINES; Fiscal Year: 2001
    ..We have previously characterized two forms of HO enzymes: HO-1, which is now recognized as a stress protein (HSP32) and is inducible by a host of toxic environmental agents; and HO-2, which is induced by adrenal glucocorticoids ..
  11. 2006 Tetrapyrroles Chemistry and Biology of Gordon Research Conference
    Ann Smith; Fiscal Year: 2006
    ..The strengths of this established GRC are its disciplinary diversity, focus on new unpublished work, time for discussion, informal atmosphere and ban on dissemination of conference proceedings. [unreadable] [unreadable]..
  12. Delayed Neurodegeneration After Intracerebral Hemorrhage
    Guohua Xi; Fiscal Year: 2007
    ..If our hypotheses are correct, these experiments may lead to novel therapies for ICH by either limiting iron overload or attenuating oxidative brain injury. [unreadable] [unreadable]..
  13. MECHANISMS OF BRAIN EDEMA AFTER INTRACEREBRAL HEMORRHAGE
    Guohua Xi; Fiscal Year: 2009
    ..The purpose of our project is to investigate the mechanisms involved in thrombin-induced brain edema. If our hypotheses are correct, these experiments may lead to novel methods of treating ICH. ..
  14. Bilirubin oxidation and intracerebral hemorrhage
    Joseph Clark; Fiscal Year: 2009
    ..These studies are important because we believe that strategies designed to prevent BOXes production in the hematoma should provide a novel and beneficial therapeutic option for patients who have suffered an ICH. ..
  15. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010
    ..abstract_text> ..
  16. FSHD: Chromatin Structure, Looping, & Expression
    Melanie Ehrlich; Fiscal Year: 2009
    ..The proposed research should elucidate new aspects of long-distance control of gene expression as well as lending clinically useful insights into this currently intractable disease. ..
  17. Biochemical Mechanisms of Vasospasms
    Joseph Clark; Fiscal Year: 2003
    ..The ultimate long-term goal for this project is to define the molecular causes of vasospasm in order to develop effective diagnostic, therapeutic and preventative approaches for this cerebral vascular disease. ..
  18. STRUCTURAL DETERMINANTS OF FAD and FMN-REQUIRING ENZYMES
    Bettie Sue Masters; Fiscal Year: 2005
    ..Upon determination of the unique structural features in the flavoprotein domains of constitutive isoforms in comparison with inducible NOS and CYPOR, a basis for drug design could develop. ..
  19. FSHD Syndrome: DNA Repeats, Methylation, & Chromatin
    Melanie Ehrlich; Fiscal Year: 2003
    ..The proposed research should help elucidate the molecular etiology of the enigmatic FSHD syndrome. ..
  20. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2005
    ..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..
  21. BIOLOGY AND CONTROL OF LYME DISEASE BORRELIA
    Alan Barbour; Fiscal Year: 2004
    ..burgdorferi, its transmission, and reservoir host immunize responses. The results may also have relevance for the control of other vector-bone zoonotic diseases and perhaps for development of novel methods for vaccine delivery. ..
  22. HYPOXIC RESPONSES OF MEDULLARY CARDIORESPIRATORY NEURONS
    Judith Neubauer; Fiscal Year: 2001
    ..In fact, failure to gasp has been proposed as a potential cause of sudden infant death syndrome. ..
  23. Hemodynamic forces regulate BMPs in coronary arteries
    Zoltan Ungvari; Fiscal Year: 2009
    ..abstract_text> ..
  24. IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS
    Scott Burchiel; Fiscal Year: 2001
    ..Finally, in Aim 4 we will assess the role of monocyte and P450 expression by Western blot and RT-PCR methods in subsets of HPBMC and human cell lines (above). ..
  25. Heme Oxygenase-Regulation, Function&Clinical Application
    MAHIN MAINES; Fiscal Year: 2003
    ....
  26. Developing antibodies to diagnose cerebral vasospasm
    Joseph Clark; Fiscal Year: 2003
    ..These data will provide proof of concept that antibodies against BOXes can be used to diagnose and predict vasospasm in SAH patients. ..
  27. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2008
    ..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
  28. Biochemical Mechanisms of Cerebral Vasospasm
    Joseph Clark; Fiscal Year: 2005
    ....
  29. Mechanisms of Heme Transport
    Ann Smith; Fiscal Year: 2005
    ..Novel roles for redox-active, nutrient metals in signaling and gene regulation are also likely outcomes. ..
  30. Prostaglandin 19-& 20-Hydroxylation by Cytochrome P450
    Bettie Sue Masters; Fiscal Year: 2005
    ..abstract_text> ..
  31. ARGINASE AND ARTERIAL INJURY
    William Durante; Fiscal Year: 2009
    ....
  32. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  33. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  34. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    ..heme uptake pathways will have a great impact in understanding disorders associated with iron overload (hereditary hemochromatosis, iron overload secondary to blood transfusions) and nutritional iron deficiency [unreadable] [unreadable]..