Genomes and Genes
Gene Symbol: HNF1A
Description: HNF1 homeobox A
Alias: HNF-1A, HNF1, IDDM20, LFB1, MODY3, TCF-1, TCF1, hepatocyte nuclear factor 1-alpha, HNF-1-alpha, albumin proximal factor, hepatic nuclear factor 1, interferon production regulator factor, liver-specific transcription factor LF-B1, transcription factor 1, hepatic
Publications221 found, 100 shown here
- HNF-1alpha G574S is a functional variant with decreased transactivation activityK Navalón-García
Instituto Politécnico Nacional Escuela Superior de Medicins, Sección de Estudios de Postgrado e Investigación, Plan de San Luis y Díaz Mirón s n, Miguel Hidalgo, Mexico
Diabet Med 23:1295-300. 2006....
- Mutations in hepatocyte nuclear factor-1beta and their related phenotypesE L Edghill
J Med Genet 43:84-90. 2006..Thirty HNF-1beta mutations have been reported in patients with renal cysts and other renal developmental disorders, young-onset diabetes, pancreatic atrophy, abnormal liver function tests, and genital tract abnormalities...
- Hepatic nuclear factor 1-alpha: inflammation, genetics, and atherosclerosisAngela D Armendariz
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Curr Opin Lipidol 20:106-11. 2009....
- Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell functionSara K Hansen
Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
J Clin Invest 110:827-33. 2002..Furthermore, they indicate that this regulation is essential to maintain normal pancreatic function...
- Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitusJianPing Weng
Department of Endocrinology, Malmo University Hospital, Lund University, Malmo, Sweden
Diabetes Care 25:68-71. 2002..To investigate whether genetic susceptibility to type 1 diabetes or maturity-onset diabetes of the young (MODY) increases susceptibility to gestational diabetes mellitus (GDM)...
- Half of clinically defined maturity-onset diabetes of the young patients in Denmark do not have mutations in HNF4A, GCK, and TCF1A Johansen
Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
J Clin Endocrinol Metab 90:4607-14. 2005..study were to examine the prevalence and nature of mutations in the three common MODY genes, HNF4A, GCK, and TCF1, in Danish patients with a clinical diagnosis of MODY and to describe metabolic differences in probands with and ..
- Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signalingElisabeth Maier
Department of Molecular Biology, University of Salzburg, Hellbrunner Strasse 34, A 5020 Salzburg, Austria
J Biol Chem 286:919-28. 2011..Thus, this study provides a model for an IL-4/STAT6-dependent fine tuning mechanism of TCF-1-driven T helper cell polarization...
- Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American womenAlex P Reiner
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Am J Hum Genet 91:502-12. 2012..previously associated with CRP through GWASs of European populations, most loci (LEPR, IL1RN, IL6R, GCKR, NLRP3, HNF1A, HNF4A, and APOC1) showed consistent patterns of association with CRP in AA and HA women...
- Clinical differences between patients with MODY-3, MODY-2 and type 2 diabetes mellitus with I27L polymorphism in the HNF1alpha genePedro José Pinés Corrales
Sección de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Albacete, Albacete, Espana
Endocrinol Nutr 57:4-8. 2010..The aim of our study was to describe and evaluate the clinical and metabolic characteristics of patients with MODY-3, MODY-2 or type 2 diabetes who presented I27L polymorphism in the HNF1alpha gene...
- Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase geneC Mitchelmore
Department of Medical Biochemistry and Genetics, Biochemical Laboratory C, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
Biochem J 346:529-35. 2000..Synergistic interaction between tissue-restricted factors is likely to be an important mechanism for reinforcing developmental and tissue-specific gene expression within the intestine...
- Genetic Loci associated with C-reactive protein levels and risk of coronary heart diseasePaul Elliott
Faculty of Medicine, Imperial College London, London, United Kingdom
JAMA 302:37-48. 2009..Plasma levels of C-reactive protein (CRP) are independently associated with risk of coronary heart disease, but whether CRP is causally associated with coronary heart disease or merely a marker of underlying atherosclerosis is uncertain...
- Can complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)?E Karlsson
Department of Clinical Sciences Diabetes and Endocrinology, Malmo University Hospital, Lund University, Malmo, Sweden
Diabet Med 25:788-91. 2008..We therefore set out to determine whether serum concentrations of C5, C8 and TTR can be used as biomarkers for patients with HNF4A-MODY and HNF1A-MODY.
- Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cellsWilliam Donelan
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
J Biol Chem 285:12181-9. 2010..Abnormal expression of HNF1alpha leads to development of MODY3 (maturity-onset diabetes of the young 3). We report that NK6 homeodomain 1 (NKX6...
- Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 AntibodiesSven Pörksen
Department of Pediatrics, Glostrup Hospital and University of Copenhagen, Copenhagen, Denmark
BMC Endocr Disord 10:16. 2010..Furthermore the study aimed at determining whether mutations in KCNJ11, ABCC8, HNF1A, HNF4A or INS are common in AAB negative diabetes.
- A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expressionAndrew A Grimm
Department of Developmental Biology Department of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Aging Cell 10:305-17. 2011..These findings reveal a novel nutrient-dependent interaction between Sirt1 and HNF-1α and provide important insight into the molecular mechanism by which Sirt1 mediates the anti-aging effects of diet restriction...
- Opposite regulation of the human apolipoprotein M gene by hepatocyte nuclear factor 1 and Jun transcription factorsIoanna Mosialou
Department of Basic Sciences, University of Crete Medical School, Heraklion 71003, Greece
J Biol Chem 286:17259-69. 2011..Our studies provide novel insights on the mechanisms that control the expression of liver-specific apolipoprotein genes during inflammation and could affect the maturation and the functionality of HDL particles...
- Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylationLi Jin
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Pharmacol Exp Ther 340:648-55. 2012..expression of transporters in mice involves the coordinated regulation by hepatocyte nuclear factor 1 (HNF1) and DNA methylation...
- Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in miceAparna Purushotham
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Mol Cell Biol 32:1226-36. 2012..We provide evidence that SIRT1 regulates the expression of FXR through hepatocyte nuclear factor 1α (HNF1α). SIRT1 deficiency in hepatocytes leads to decreased binding of HNF1α to the FXR promoter...
- NR2F1 disrupts synergistic activation of the MTTP gene transcription by HNF-4α and HNF-1αKezhi Dai
Departments of Cell Biology and Pediatrics, Program of Molecular and Cellular Biology, School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, NY, USA
J Lipid Res 53:901-8. 2012..In this mechanism, NR2F1 does not affect activities of individual transcription factors; instead, it abrogates synergistic activation by HNF-4α and HNF-1 proteins...
- Regulation of LEF-1/TCF transcription factors by Wnt and other signalsQ Eastman
Howard Hughes Medical Institute, Department of Microbiology and Immunology, 513 Parnassus Avenue, University of California San Francisco, CA 94143, USA
Curr Opin Cell Biol 11:233-40. 1999..The LEF-1/TCF transcription factors can also interact with other cofactors and play an architectural role in the assembly of multiprotein enhancer complexes, which may allow for the integration of multiple signaling pathways...
- Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylationRyota Kikuchi
Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Mol Pharmacol 70:887-96. 2006..pairs upstream of the transcriptional start site, where there are canonical TATA and hepatocyte nuclear factor (HNF1) binding motifs, which are conserved in the rodent Oat3 genes...
- HNF1alpha controls renal glucose reabsorption in mouse and manM Pontoglio
Unite des Virus Oncogenes, URA 1644 CNRS, Departement des Biotechnologies, Institut Pasteur, Paris, France
EMBO Rep 1:359-65. 2000..that is expressed in liver, kidney, pancreas and intestine, result in maturity onset diabetes of the young type 3 (MODY3)...
- The prevalence of the HNF-1alpha G319S mutation in Canadian aboriginal youth with type 2 diabetesElizabeth A C Sellers
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada
Diabetes Care 25:2202-6. 2002....
- NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)Misato Yamada
Department of Molecular Cell Biology, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, JST, Chiyoda ku, Japan
J Biol Chem 281:20749-60. 2006..Collectively, our findings raise the possibility that NARF functions as a novel ubiquitin-ligase to suppress the Wnt-beta-catenin signaling...
- A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin-treated patientsM Shepherd
Institute of Health and Social Care Research Peninsula Medical School, Exeter, UK
Diabet Med 26:437-41. 2009Hepatocyte nuclear factor-1 alpha (HNF1A) gene mutations are the commonest cause of monogenic diabetes, but patients are often misdiagnosed as having Type 1 diabetes and started on insulin treatment...
- Evaluation of serum 1,5 anhydroglucitol levels as a clinical test to differentiate subtypes of diabetesAparna Pal
Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
Diabetes Care 33:252-7. 2010..1,5 anhydroglucitol (1,5AG) levels were reported to differentiate maturity-onset diabetes of the young due to HNF1A mutations (HNF1A-MODY) from type 2 diabetes, but this requires further validation...
- Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylationGordan Lauc
Glycobiology Laboratory, Genos Ltd, Zagreb, Croatia
PLoS Genet 6:e1001256. 2010..of 2,705 individuals in three population cohorts showed that common variants in the Hepatocyte Nuclear Factor 1α (HNF1α) and fucosyltransferase genes FUT6 and FUT8 influence N-glycan levels in human plasma...
- Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promotersG Courtois
Department of Pathology, Stanford University School of Medicine, CA 94305
Proc Natl Acad Sci U S A 85:7937-41. 1988..We also show that this protein binds to the promoter of the surface-antigen gene of the hepatitis B virus, a virus characterized by a high degree of hepatotropism...
- Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteinsE Soutoglou
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, 711 10 Herakleion Crete, Greece
J Biol Chem 275:12515-20. 2000..The results support a model that involves the combined action of multiple coactivators recruited by HNF-1, which activate transcription by coupling nucleosome modification and recruitment of the general transcription machinery...
- Identifying hepatic nuclear factor 1alpha mutations in children and young adults with a clinical diagnosis of type 1 diabetesA Paul Lambert
Department of Diabetes and Metabolism, Division of Medicine, University of Bristol, UK
Diabetes Care 26:333-7. 2003HNF-1alpha gene mutations (MODY3) present with marked hyperglycemia in lean young adults and may, therefore, be mistaken for type 1 diabetes, with implications for individual treatment and risk of diabetes in other family members...
- The A98V single nucleotide polymorphism (SNP) in hepatic nuclear factor 1 alpha (HNF-1alpha) is associated with insulin sensitivity and beta-cell functionA Bergmann
Health Care Centre of Medical Faculty Carl Gustav Carus of the Technical University, Dresden, Germany
Exp Clin Endocrinol Diabetes 116:S50-5. 2008..The aims of the study was to determine whether two single nucleotide polymorphisms (SNPs) ile27-to-leu and ala98-to-val in the HNF-1alpha gene associate with diabetes, insulin sensitivity as well as beta-cell function...
- The predominant expression of hepatocyte nuclear factor 4α (HNF4α) in thyroid transcription factor-1 (TTF-1)-negative pulmonary adenocarcinomaRyosuke Kunii
Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Hospital, Niigata, Japan
Histopathology 58:467-76. 2011..To investigate TTF-1-negative pulmonary adenocarcinoma, focusing upon mucin production and the expression of hepatocyte nuclear factor-4α (HNF4α)...
- HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitroD B Mendel
Beckman Center for Molecular and Genetic Medicine, Howard Hughes Medical Institute, Stanford University Medical School, California 94305
Genes Dev 5:1042-56. 1991..These studies define a pair of homeo domain proteins that have the potential to interact to produce an embryologically complex pattern of gene expression...
- More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processingI Bach
Unite des Virus Oncogenes, UA 1644 du CNRS, Departement des Biotechnologies, Institut Pasteur, Paris, France
EMBO J 12:4229-42. 1993..the isolation of cDNAs from human liver encoding several isoforms of the hepatocyte nuclear factor homeoproteins HNF1 and vHNF1 generated by the differential use of polyadenylation sites and by alternative splicing...
- Mutations in the hepatocyte nuclear factor-1alpha gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4P J Kaisaki
Howard Hughes Medical Institute, Department of Biochemistry, University of Chicago, Illinois 60637, USA
Diabetes 46:528-35. 1997..factor hepatocyte nuclear factor (HNF)-1alpha are the cause of one form of maturity-onset diabetes of the young (MODY3). Here, we report the exon-intron organization and partial sequence of the human HNF-1alpha gene...
- Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.KT M Frayling
Institute of Clinical Science, University of Exeter, Devon, U K
Diabetes 46:720-5. 1997..K. families and result in early onset NIDDM with a progressive clinical course. Mutation-based genetic counseling can now be considered for the majority of patients with MODY...
- Mutations in the hepatocyte nuclear factor-1alpha/MODY3 gene in Japanese subjects with early- and late-onset NIDDMN Iwasaki
Diabetes Center, Tokyo Women s Medical College, Japan
Diabetes 46:1504-8. 1997..in the hepatocyte nuclear factor (HNF)-1alpha gene are the cause of maturity-onset diabetes of the young type 3 (MODY3)...
- The hepatic nuclear factor-1alpha G319S variant is associated with early-onset type 2 diabetes in Canadian Oji-CreeR A Hegele
Robarts Research Institute, University of Western Ontario, London, Canada
J Clin Endocrinol Metab 84:1077-82. 1999..Also, G319S is associated with a distinct form of type 2 diabetes, characterized by onset at an earlier age, lower body mass, and a higher postchallenge plasma glucose...
- Octamer transcription factor-1 enhances hepatic nuclear factor-1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoterY Ishii
Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, South Australia, Australia
Mol Pharmacol 57:940-7. 2000..UGT2B7 promoter activity with the HNF1/AT-rich element was stimulated by cotransfection with HNF1alpha...
- Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1alpha gene mutation carriersAmanda Stride
Department of Diabetes and Vascular Medicine, University of Exeter, Devon, UK
Diabetes Care 25:2287-91. 2002....
- Association of common variation in the HNF1alpha gene region with risk of type 2 diabetesWendy Winckler
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Diabetes 54:2336-42. 2005..The gene for MODY3 diabetes, HNF1alpha, lies in a region that has shown linkage to late-onset type 2 diabetes (12q24, NIDDM2), and ..
- Hepatocyte nuclear factor1 transcription factors are essential for the UDP-glucuronosyltransferase 1A9 promoter response to hepatocyte nuclear factor 4alphaDione A Gardner-Stephen
Department of Clinical Pharmacology, Flinders University School of Medicine, Flinders Medical Centre, South Australia, Australia
Pharmacogenet Genomics 17:25-36. 2007..The discovery of two unique and cooperative liver-enriched transcription factor binding sites in the UGT1A9 promoter is a significant step towards understanding the unique hepatic expression of UGT1A9 amongst the UGT1A7-10 gene cluster...
- Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetesWendy Winckler
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
Diabetes 56:685-93. 2007..We combined these results with our previous studies on HNF4alpha and TCF1 and explicitly tested for gene-gene interactions among these variants and with several known type 2 diabetes ..
- Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the youngS Ellard
Institute of Biomedical Science and Clinical Medicine, Peninsula Medical School, Exeter, UK
Diabetologia 50:2313-7. 2007Heterozygous mutations of glucokinase (GCK) and hepatocyte nuclear factor-1 alpha (HNF1A; also known as hepatic transcription factor 1 [TCF1]) genes are the most common cause of MODY...
- The transcription factor HNF1 acts with C/EBP alpha to synergistically activate the human albumin promoter through a novel domainK J Wu
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
J Biol Chem 269:1177-82. 1994b>HNF1 and C/EBP alpha are transcription factors that bind to and trans-activate the human albumin gene proximal promoter...
- Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)K Yamagata
Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
Nature 384:455-8. 1996..Here we show that subjects with the MODY3-form of NIDDM have mutations in the gene encoding hepatocyte nuclear factor-1alpha (HNF-1alpha, which is encoded ..
- The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activityD J Sourdive
Unite des Virus Oncogenes, URA 1644 du CNRS, Departement des Biotechnologies, U163 INSERM, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
Nucleic Acids Res 25:1476-84. 1997b>HNF1 is a liver enriched atypical homeoprotein isolated from vertebrates which is involved in the transcriptional activation of liver, kidney, intestine and pancreas specific genes...
- Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3)M Vaxillaire
CNRS EP10, Institut Pasteur de Lille and CHU de Lille, France
Hum Mol Genet 6:583-6. 1997..two functionally related transcription factors, hepatocyte nuclear factor 4 alpha (HNF-4alpha) and hepatocyte nuclear factor 1 alpha (HNF-1alpha) are associated with the MODY1 and MODY3 forms of diabetes respectively, whereas ..
- Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDMS A Urhammer
Steno Diabetes Center, Copenhagen, Denmark
Diabetologia 40:473-5. 1997..genome mapping study has localized a locus termed NIDDM2 that maps to the region of chromosome 12 that includes MODY3, one of the three genes responsible for maturity-onset diabetes of the young, a monogenic form of NIDDM ..
- A rapid screening method for hepatocyte nuclear factor 1 alpha frameshift mutations; prevalence in maturity-onset diabetes of the young and late-onset non-insulin dependent diabetesT M Frayling
Division of Molecular Genetics, University of Exeter, UK
Hum Genet 101:351-4. 1997..Mutations in the hepatocyte nuclear factor 1 alpha (HNF-1 alpha) gene have recently been shown to cause MODY...
- Hepatocyte nuclear factor 1alpha coding mutations are an uncommon contributor to early-onset type 2 diabetes in Ashkenazi JewsP S Behn
Division of Metabolism, Endocrinology and Diabetes, Washington University Medical School, St Louis, Missouri 63110, USA
Diabetes 47:967-9. 1998
- Retinoic acid mediates down-regulation of the alpha-fetoprotein gene through decreased expression of hepatocyte nuclear factorsT R Magee
Department of Pathology, Harbor UCLA Medical Center, Torrance, California 90509, USA
J Biol Chem 273:30024-32. 1998..In addition, HNF4, which is not known to bind to the AFP promoter but does regulate HNF1, was also diminished. The levels of HNF1 and HNF4 mRNA were also decreased following RA treatment...
- Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterizationI Yoshiuchi
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
Diabetologia 42:621-6. 1999..We examined the clinical features and molecular basis of hepatocyte nuclear factor-1alpha (HNF-1alpha) diabetes...
- Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunctionH Wang
Division de Biochimie Clinique et de Diabétologie Expérimentale, Départment de Médecine Interne, Centre Medical Universitaire, CH 1211 Geneva 4, Switzerland
EMBO J 19:4257-64. 2000..alpha)-P291fsinsC, the most common mutation associated with subtype 3 of maturity-onset diabetes of the young (MODY3)...
- Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injuryJ I Leu
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Mol Cell Biol 21:414-24. 2001....
- The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuriaC Bingham
Department of Vascular Medicine and Diabetes Research, School of Postgraduate Medicine and Health Sciences, University of Exeter, Devon, UK
Diabetes 50:2047-52. 2001..Glucose may depolarize and dissipate the electrical gradient of the sodium-dependent amino acid transporters in the proximal renal tubule, causing a reduction in amino acid resorption...
- Prevalence of the missense mutation Gly574Ser in the hepatocyte nuclear factor-1alpha in Africans with diabetesC Collet
Service d endocrinologie, Hopital d Instruction des armees BEGIN, 94160 Saint Mande, France
Diabetes Metab 28:39-44. 2002..This peculiar disease course could be at least partly related to a specific genetic profile that has not been studied in this population...
- Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoterNobuhiro Ban
Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Japan
Diabetes 51:1409-18. 2002..In addition, these results provided new insight into the regulatory function of HNF-1alpha by suggesting a molecular basis for human GLUT2 gene expression...
- Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoterHerbert M van Wering
Division of Gastroenterology and Nutrition, Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 277:27659-67. 2002..Parallel mechanisms in other tissues as well as in Drosophila suggest that zinc finger/homeodomain interactions are an efficient pathway of cooperative activation of gene transcription that has been conserved throughout evolution...
- Bi-allelic inactivation of TCF1 in hepatic adenomasOlivier Bluteau
INSERM U434, Fondation Jean Dausset, 27 rue Juliette Dodu, 75010 Paris, France
Nat Genet 32:312-5. 2002..mutations of TCF1 have been identified in individuals affected with maturity-onset diabetes of the young type 3 (MODY3; ref. 3)...
- Diabetes mutations delineate an atypical POU domain in HNF-1alphaYoung In Chi
Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
Mol Cell 10:1129-37. 2002..The numerous diabetes-causing mutations in HNF-1alpha thus identified a previously unrecognized POU domain which was used as a search model to identify additional POU domain proteins in sequence databases...
- Determinants of the development of diabetes (maturity-onset diabetes of the young-3) in carriers of HNF-1alpha mutations: evidence for parent-of-origin effectTomasz Klupa
Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes Care 25:2292-301. 2002To determine the distribution of the age at onset of diabetes (maturity-onset diabetes of the young-3 [MODY3]) and to identify determinants of the onset of diabetes in carriers of HNF-1alpha mutations.
- Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in NorwayLise Bjørkhaug
Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, N 5021 Bergen, Norway
J Clin Endocrinol Metab 88:920-31. 2003..To estimate the prevalence of MODY3 in Norwegian diabetic pedigrees, we screened a total of 130 families for HNF-1 alpha mutations; 42 families with ..
- Comparison of the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha on estimated and measured beta cell indicesKen C Chiu
Division of Endocrinology, Diabetes and Hypertension, University of California Los Angeles School of Medicine, Los Angeles, CA, USA
Eur J Endocrinol 148:641-7. 2003..We investigated the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha gene on measured and estimated beta cell indices. We also examined the conservation of this amino acid among different species...
- Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decayLorna W Harries
Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, U K
Diabetes 53:500-4. 2004..Haploinsufficiency is therefore likely to be the most important mutational mechanism of HNF-1alpha mutations causing MODY...
- Control of pancreas and liver gene expression by HNF transcription factorsDuncan T Odom
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 303:1378-81. 2004..Our results suggest how misregulation of HNF4alpha can contribute to type 2 diabetes...
- Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutationsEwan R Pearson
Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UK
Diabetes Care 27:1102-7. 2004..However, physiological assessment of the HNF-1beta phenotype is limited. We aimed to test the hypothesis that the diabetes phenotype due to HNF-1beta mutations is similar to that in HNF-1alpha...
- Mutation of TCF1 encoding hepatocyte nuclear factor 1alpha in gynecological cancerSandra Rebouissou
INSERM U434, 27 rue Juliette Dodu, 75010 Paris, France
Oncogene 23:7588-92. 2004b>TCF1: (transcription factor 1) encoding hepatocyte nuclear factor 1alpha (HNF1alpha) is mutated in 50% of liver cell adenomas, a benign tumor closely associated with oral contraceptive use...
- Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytesTakeaki Dohda
Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
J Biochem 136:313-9. 2004..In addition, inhibition of CBP or p300 using small interfering RNAs (siRNAs) resulted in a reduction in albumin expression. These results suggest that both CBP and p300 are required for enhanced expression of albumin...
- A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian populationMichael N Weedon
Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
Diabetes 54:2487-91. 2005HNF1alpha (TCF1) is a key transcription factor that is essential for pancreatic beta-cell development and function. Rare mutations of HNF1alpha cause maturity-onset diabetes of the young...
- A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian IndiansShekher Anuradha
Dr Mohans MV Diabetes Specialties Centre and Madras Diabetes Research Foundation, Gopalapuram, Chennai, India
Diabetes Care 28:2430-5. 2005..The aim of this study was to estimate the prevalence of Ala98Val polymorphism of the HNF1alpha gene in different types of diabetes in Asian Indians...
- Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetesLorna W Harries
Institute of Biomedical and Clincal Sciences, Peninsula Medical School, Barrack Road, Exeter, Devon, UK
Hum Mol Genet 15:2216-24. 2006..Heterozygous mutations in the transcription factor hepatocyte nuclear factor-1 alpha (HNF1A or TCF1 gene) result in early-onset diabetes as a result of pancreatic beta-cell dysfunction...
- Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjectsNorihide Yokoi
Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
Diabetes 55:2379-86. 2006..We examined the association of variants in genes encoding several transcription factors (TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2-2, NKX6-1, and NEUROD1) and genes encoding the ATP-sensitive K(+) ..
- Common variants in HNF-1 alpha and risk of type 2 diabetesJ Holmkvist
Department of Clinical Sciences, Diabetes and Endocrinology, Clinical Research Center, Malmo University Hospital, Lund University, S 205 02, Malmo, Sweden
Diabetologia 49:2882-91. 2006..now known as the transcription factor 1 gene [TCF1]) cause the most common monogenic form of diabetes, MODY3, but it is not known if common variants in HNF-1a are associated with decreased transcriptional activity or ..
- The type and the position of HNF1A mutation modulate age at diagnosis of diabetes in patients with maturity-onset diabetes of the young (MODY)-3Christine Bellanne-Chantelot
Département de génétique, Groupe Hospitalier Pitie Salpetriere, Bât 6 rue Lapeyronie, 47 83 boulevard de l Hopital, 75651 Paris Cedex 13, France
Diabetes 57:503-8. 2008..This may be due to environmental and/or genetic factors, including molecular characteristics of the hepatocyte nuclear factor 1-alpha (HNF1A) gene mutation.
- Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetesJohan Holmkvist
Department of Clinical Sciences Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmo, Sweden
Diabetes 57:1738-44. 2008....
- Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health StudyPaul M Ridker
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Hum Genet 82:1185-92. 2008..9 x 10(-)(8) to 6.2 x 10(-)(28)). Two of these loci (GCKR and HNF1A) are suspected or known to be associated with maturity-onset diabetes of the young, one is a gene-desert region on ..
- Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive proteinAlexander P Reiner
University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
Am J Hum Genet 82:1193-201. 2008..Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive protein (CRP) concentration...
- Diabetes susceptibility in the Canadian Oji-Cree population is moderated by abnormal mRNA processing of HNF1A G319S transcriptsLorna W Harries
Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, U K
Diabetes 57:1978-82. 2008The G319S HNF1A variant is associated with an increased risk of type 2 diabetes in the Canadian Oji-Cree population...
- Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymesXin Yuan
Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
Am J Hum Genet 83:520-8. 2008..chromosome 10 and PNPLA3-SAMM50 on chromosome 22), one locus influencing gamma-glutamyl transferase (GGT) levels (HNF1A on chromosome 12), and three loci for alkaline phosphatase (ALP) levels (ALPL on chromosome 1, GPLD1 on chromosome ..
- New susceptibility locus for coronary artery disease on chromosome 3q22.3Jeanette Erdmann
Medizinische Klinik II, Universitat zu Lubeck, 23538 Lubeck, Germany
Nat Genet 41:280-2. 2009..We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
- Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1Alexander J Michels
Linus Pauling Institute and the Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA
Am J Physiol Cell Physiol 297:C1220-7. 2009..within this sequence, reporter constructs showed that basal transcription required the binding of hepatic nuclear factor 1 (HNF-1) to its cognate sequence...
- A Wnt kinase network alters nuclear localization of TCF-1 in colon cancerR Najdi
Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697, USA
Oncogene 28:4133-46. 2009..We propose that dnTCF-1 provides homeostatic regulation of Wnt signaling and growth in normal colon, and the alterations in nuclear export and promoter usage contribute to aberrant Wnt activity in colon cancer...
- Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The CardiovasculaAlexander P Reiner
Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
Circ Cardiovasc Genet 2:244-54. 2009..Common polymorphisms of the HNF-1 alpha gene (HNF1A) were recently associated with plasma C-reactive protein and gamma-glutamyl transferase concentration in middle-..
- Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damageEmmanuelle Jeannot
Institut National de Santé et de Recherche Médicale, U674, Génomique fonctionnelle des tumeurs solides, Paris, France
Diabetes 59:1836-44. 2010Maturity onset diabetes of the young type 3 (MODY3) is a consequence of heterozygous germline mutation in HNF1A...
- Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological studySylvia H Ley
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Cardiovasc Diabetol 9:39. 2010..Common variants of the hepatocyte nuclear factor 1A (HNF1A) gene encoding HNF-1alpha have been associated with plasma CRP in predominantly European Caucasian samples...
- Effect of the rs2259816 polymorphism in the HNF1A gene on circulating levels of c-reactive protein and coronary artery disease (the ludwigshafen risk and cardiovascular health study)Marcus E Kleber
Synlab Centre of Laboratory Diagnostics, Heidelberg, Germany
BMC Med Genet 11:157. 2010..It is still controversial if it plays an active role in the development of cardiovascular disease. Recently, polymorphisms in the gene for HNF1α have been linked to the levels of C-reactive protein and coronary artery disease.
- Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locusBrandon L Pierce
Department of Health Studies and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois 60637, USA
Cancer Res 71:4352-8. 2011..Of the 1,087 SNPs tested, the strongest association observed was for HNF1A SNP rs7310409 (P = 3 × 10(-5); P(Bonferroni) = 0...
- Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the youngGaya Thanabalasingham
Oxford Centre for Diabetes, Endocrinology andMetabolism, University of Oxford, U K
Diabetes Care 35:1206-12. 2012..This cross-sectional study examined diagnostic misclassification of MODY in subjects with clinically labeled young adult-onset type 1 and type 2 diabetes by extending genetic testing beyond current guidelines...
- Genetic associations with C-reactive protein level and white blood cell count in the KARE studyM Kong
School of Systems Biomedical Science, Soongsil University, Seoul, Korea
Int J Immunogenet 40:120-5. 2013..The only common variant associated with CRP was rs2393791 within hepatocyte nuclear factor 1 alpha (HNF1A) gene [minor allele frequency (MAF) = 0.478]...
- Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1AJason W Hoskins
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, Epithelial Carcinogenesis Group, CNIO Spanish National Cancer Research Centre, E 28029 Madrid, Spain, Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute and Bioinformatics and Molecular Analysis Section, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA, Department of Laboratory Medicine and Pathology and Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
Carcinogenesis 35:2670-8. 2014..Sub-network enrichment analyses identified HNF1A as the regulator of the most significantly and consistently dysregulated expression sub-network in pancreatic ..
- Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutationT Hansen
Steno Diabetes Center and Hagendorn Research Institute, Copenhagen, Denmark
Diabetes 46:726-30. 1997One form of maturity-onset diabetes of the young (MODY3) results from mutations in the hepatocyte nuclear factor (HNF)-1alpha gene, located on chromosome 12q24.2...
- Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the youngM P Bulman
Centre for Molecular Genetics, School of Postgraduate Medicine and Health Sciences, University of Exeter, Exeter EX2 5AX, UK
Diabetologia 45:1463-7. 2002..This study aimed to define the pathogenic mechanism in three novel splice site mutations by analysing illegitimate transcripts...
- Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutationsHeike Thomas
Universitatsklinikum Essen, Institut für Zellbiologie Tumorforschung, Hufelandstrasse 55, D 45122 Essen, Germany
Biol Chem 383:1691-700. 2002..In humans mutations in the HNF1 gene are responsible for one form of maturity onset diabetes of the young (MODY3)...
- Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol levelNaru Babaya
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
J Clin Endocrinol Metab 88:2548-51. 2003..These results demonstrate that the HNF-1 alpha gene locus is associated with serum HDL-c level and suggest that the Ile27 allele is a risk marker for atherosclerosis...
- Serum amino acids in patients with mutations in the hepatocyte nuclear factor-1 alpha geneA Stride
Department of Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UK
Diabet Med 21:928-30. 2004Knockout mice lacking both copies of the hepatocyte nuclear factor 1 (HNF1) gene have altered serum levels of amino acids and generalized aminoaciduria...
- Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigsKazuhiro Umeyama
BIOS Research Laboratory Inc, Hiratsuka, Kanagawa 254 0031, Japan
Transgenic Res 18:697-706. 2009..Histochemical analysis of pancreas tissue from the cloned pigs showed small and irregularly formed Langerhans Islets, in which poor insulin secretion was detected...
- Two members of an HNF1 homeoprotein family are expressed in human liverI Bach
UA 041149 du CNRS, Departement des Biotechnologies, Institut Pasteur, Paris, France
Nucleic Acids Res 19:3553-9. 1991b>HNF1 is a transcriptional activator, required for the liver-specific expression of a variety of genes, that binds to DNA as a dimer via the most diverged homeodomain known so far...
- A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12qM Vaxillaire
CNRS EP10, Institut Pasteur de Lille, France
Nat Genet 9:418-23. 1995..These MODY patients exhibit major hyperglycaemia with a severe insulin secretory defect, suggesting that the causal gene is implicated in pancreatic beta-cell function...
- Novel mutations and a mutational hotspot in the MODY3 geneM A Glucksmann
Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
Diabetes 46:1081-6. 1997Maturity-onset diabetes of the young 3 (MODY3) is a type of NIDDM caused by mutations in the transcription factor hepatocyte nuclear factor-1alpha (HNF-1alpha) located on chromosome 12q...
- Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha geneC Gragnoli
Howard Hughes Medical Institute, University of Chicago, Illinois, USA
Diabetes 46:1648-51. 1997..factor hepatocyte nuclear factor (HNF)-1 alpha are the cause of one form of maturity-onset diabetes of the young (MODY3)...
- Samir S El-Dahr; Fiscal Year: 2014..that p-p53Ser23, which accumulates in dysplastic BdkrB2-/- kidneys, represses Hepatocyte Nuclear Factor-1 (HNF1[unreadable]) gene transcription...
- Michael H Court; Fiscal Year: 2015..in model cell lines and primary human hepatocytes on specific candidate transcription factor proteins (PXR and HNF1) as well as the entire proteome (iTRAQ LC-MS/MS method)...
- Megan R Determan; Fiscal Year: 2016..of monogenic diabetes in humans and results from a haploinsufficiency of the transcription factor hepatocyte nuclear factor 1 alpha (HNF1A)...
- JAMEY MARTH; Fiscal Year: 2016..in multiple metabolic roles including the pathogenesis of human Mature Onset Diabetes of the Young subtype 3 (MODY3), susceptibility to diabetes among mammalian populations, and the physiological response to nutrient deprivation ..
- Metabolic and Mitochondrial Defects of Islet beta-cells of MODY-3Gary Cline; Fiscal Year: 2009..MODY-3 is an inherited defect that has been linked to a dominant negative mutation of the hepatic nuclear factor 1 alpha (HNF-1alpha) transcription factor...
- Weibin Shi; Fiscal Year: 2016..In Aim 2, we will conduct functional study to test Hnf1a as a promising candidate gene for the chromosome 5 QTLs...
- G-quadruplex in Translational Regulation and Cancer TherapyHong Lu; Fiscal Year: 2013..Aim 2 will determine role of G4 motif within 5'UTR of human HNF1?, HNF3?, C/EBP?, C/EBP?, HDAC3, NCOR1, and p53 in regulating protein expression...
- CHARLES ALFRED STANLEY; Fiscal Year: 2016..candidate genes, including the novel gene on 10q that will be identified in Aim 1, HADH/SCHAD, SLC16A1/MCT-1, TCF1/HNF1, TCF4/HNF4, SIR2L4/SIRT4, and others...
- Domenico Accili; Fiscal Year: 2016..cells devlop MODY, with striking abnormalities of the transcriptional networks regulated by Hnf4a, Hnf1a, and Pd1...
- Joonsoo Kang; Fiscal Year: 2016..T?[unreadable]17 cell fate has so far revealed five essential transcription factors (TFs): SOX13, SOX4, ROR?t, TCF1 and LEF1, of which only one, ROR?t, was previously identified...
- Hai Hui Xue; Fiscal Year: 2014..The T cell factor 1 (TCF1) transcription factor is known to mediate the canonical Wnt signaling and play important roles in T cell ..
- Program Project in the Genetics of SLERobert P Kimberly; Fiscal Year: 2012..the strong association at 12q24 with SLE in Hispanics and test the hypothesis that this effect reflects variants of TCF1. Project No...
- Jingwen Liu; Fiscal Year: 2016..has made a novel discovery that PCSK9 gene transcription is regulated by the hepatocyte nuclear factor 1? (HNF1?) through a highly conserved HNF1 binding site of the PCSK9 gene promoter, whereas HNF1? binding site is absent on ..
- Hex - a Homeobox Gene Essential for Liver DevelopmentCLIFFORD BOGUE; Fiscal Year: 2007..Those genes include the critically important HNF family members HNF6, HNF1a and HNF4a as well as other factors. In order to test these hypotheses, we propose the following 3 specific aims...
- THE ROLE OF NOTCH SIGNALING IN BILE DUCT DEVELOPMENTKathleen Loomes; Fiscal Year: 2004..and assays for up- or down-regulation of other genes known to be involved in bile duct development, such as HNF6 or HNF1(...
- Molecular Mechanism of Paraxial Mesoderm FormationDeborah Chapman; Fiscal Year: 2006..The prime candidates are LEF-1/TCF1, which function through the secreted signaling molecule Wnt-3a, and RBP-JK, which functions in the Notch signaling ..
- REGULATION OF INTESTINE-SPECIFIC GENE TRANSCRIPTIONEunran Suh; Fiscal Year: 2006..protein and transcriptional activity of Cdx2 is enhanced by forming a complex with hepatocyte nuclear factor 1 (HNF1), GATA factors, and coactivators such as CBP and PCAF...
- REPLICATION AND PATHOGENESIS OF HEPATITIS B VIRUSJ H James Ou; Fiscal Year: 2001..The study will focus on a critical regulatory site that binds COUP, HNF4, PPAR-RXR, and when mutated, HNF1. Preliminary studies have also characterized an upstream negative regulatory element (NRE) that binds RFX1/MDBP1 ..
- GENETIC AND MOLECULAR ANALYSIS OF LIVER SPECIFICATIONGARY BULLA; Fiscal Year: 1999..cascade has recently been identified in which transcription factor HNF4 drives expression transcription factor HNF1 which is responsible for activating expression of a number of essential liver genes...
- HNF1 transcriptional control of renal oxidative stressPeter Doris; Fiscal Year: 2009..to be regulated by a single transcription factor abundantly expressed in kidney: hepatocyte nuclear factor 1, HNF1. In the present studies, we will extend our gene array and bioinformatics methods to develop direct evidence ..
- WNT Receptor Signaling and CancerStuart Aaronson; Fiscal Year: 2009..on our preliminary evidence, we will also attempt to identify coactivator(s) for a novel b-catenin independent TCF1/LEF1 signaling pathway...
- Genetic contributors to diabetes and dyslipidemia in African AmericansMichele M Sale; Fiscal Year: 2010..We propose applying this proven strategy to identify new therapeutic targets and allow translation to novel diagnostic, prevention, and treatment strategies for type 2 diabetes. ..
- A mouse model of stem cell deregulation and lung cancerJOSEPH LOCKER LOCKER; Fiscal Year: 2010..8 expression in human lung cancer cells. Expression profiles from these cells will be com- pared to those obtained from mouse bronchial cell fractions, to determine specific relationships between tumor and stem cell regulation. ..
- THROMBOTIC, INFLAMMATORY & GENE MARKERS OF CVD IN WOMENPaul Ridker; Fiscal Year: 2002....
- Acetaminophen PharmacogeneticsMichael H Court; Fiscal Year: 2010....
- SECONDARY PREVENTION TRIAL OF VENOUS THROMBOSISPaul Ridker; Fiscal Year: 2002....
- Lipoprotein Metabolism 2008 Gordon Research ConferenceRobert Hegele; Fiscal Year: 2008..End of Abstract) [unreadable] [unreadable] [unreadable]..
- Analysis of Fatty Liver in the Framingham Heart Study CohortELIZABETH SPELIOTES; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- LONG DISTANCE CONTROL OF LIVER GENE EXPRESSIONJoseph Locker; Fiscal Year: 2007..In the AIb _romoter, HNF1 is the critical enhancer-activating factor...
- Mechanisms of adverse host responses to antibioticsMichael Court; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..