HLA G

Summary

Gene Symbol: HLA G
Description: major histocompatibility complex, class I, G
Alias: MHC-G, HLA class I histocompatibility antigen, alpha chain G, HLA G antigen, HLA-G histocompatibility antigen, class I, G, MHC class I antigen G, b2 microglobulin
Species: human

Top Publications

  1. doi The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes
    E C Castelli
    Divisão de Imunologia Clínica, Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, Sao Paulo, Brazil
    Genes Immun 11:134-41. 2010
  2. pmc Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2
    Jinghe Huang
    Ragon Institute of MGH, Harvard, MIT, 149, 13th Street, Charlestown, MA 02129, USA
    J Virol 84:10784-91. 2010
  3. pmc HIV-1 Nef: at the crossroads
    John L Foster
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Retrovirology 5:84. 2008
  4. pmc Host determinants of HIV-1 control in African Americans
    Kimberly Pelak
    Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA
    J Infect Dis 201:1141-9. 2010
  5. ncbi IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes
    P Moreau
    CEA, Service de Recherches en Hemato Immunologie, DSV DRM, Hopital Saint Louis, Centre Hayem, 1 avenue Claude Vellefaux, 75010 Paris, France
    Int Immunol 11:803-11. 1999
  6. doi Association between HLA-G 3'UTR 14-bp polymorphism and HIV vertical transmission in Brazilian children
    Annalisa Fabris
    Genetic Service, IRCCS Burlo Garofolo, Trieste, Italy
    AIDS 23:177-82. 2009
  7. pmc Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain
    Laura L Baugh
    Y9 206, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Virol 82:9657-67. 2008
  8. doi Tolerance versus immune response -- microRNAs as important elements in the regulation of the HLA-G gene expression
    T D Veit
    Genetics Department, Post Graduation Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Transpl Immunol 20:229-31. 2009
  9. doi HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients
    Esther M de Kruijf
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 185:7452-9. 2010
  10. ncbi Association of soluble HLA-G plasma levels with HLA-G alleles
    V Rebmann
    Institute of Immunology, University Hospital of Essen, Essen, Germany
    Tissue Antigens 57:15-21. 2001

Research Grants

  1. Robust Generalization in MHC Peptide Binding Models
    Pedro Cano; Fiscal Year: 2002
  2. HLA-G AND EQUIVALENT AND FETO-MATERNAL INTERACTION
    Hidde Ploegh; Fiscal Year: 2003
  3. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
  4. Jack L Strominger; Fiscal Year: 2014
  5. ROBERT MICHAEL ROBERTS; Fiscal Year: 2015
  6. Functional Analysis of PAAN-AG5, the Baboon Counterpart of HLA-G5
    Daudi K Langat; Fiscal Year: 2010
  7. COMPARATIVE STUDIES OF PREGNANCY AND HISTOCOMPATIBILITY
    DOUGLAS ANTCZAK; Fiscal Year: 2000
  8. Mechanisms of NK Cell Activation by the KIR2DL4 Receptor
    Kerry Campbell; Fiscal Year: 2009
  9. CLASS I MHC GENES EXPRESSED BY HUMAN TROPHOBLAST CELLS
    JOAN HUNT; Fiscal Year: 1999
  10. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010

Detail Information

Publications323 found, 100 shown here

  1. doi The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes
    E C Castelli
    Divisão de Imunologia Clínica, Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, Sao Paulo, Brazil
    Genes Immun 11:134-41. 2010
    ..The detailed analyses of 3'UTR of the HLA-G locus may shed some light into mechanisms underlying the regulation of HLA-G expression...
  2. pmc Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2
    Jinghe Huang
    Ragon Institute of MGH, Harvard, MIT, 149, 13th Street, Charlestown, MA 02129, USA
    J Virol 84:10784-91. 2010
    ....
  3. pmc HIV-1 Nef: at the crossroads
    John L Foster
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Retrovirology 5:84. 2008
    ..Finally, we conclude that inhibiting the CD4 downregulation function is the most promising Nef-targeted approach for developing a new anti-viral as a contribution to combating AIDS...
  4. pmc Host determinants of HIV-1 control in African Americans
    Kimberly Pelak
    Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA
    J Infect Dis 201:1141-9. 2010
    ....
  5. ncbi IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes
    P Moreau
    CEA, Service de Recherches en Hemato Immunologie, DSV DRM, Hopital Saint Louis, Centre Hayem, 1 avenue Claude Vellefaux, 75010 Paris, France
    Int Immunol 11:803-11. 1999
    ..This should be taken into consideration in the design of treatment for pathologies of pregnancy...
  6. doi Association between HLA-G 3'UTR 14-bp polymorphism and HIV vertical transmission in Brazilian children
    Annalisa Fabris
    Genetic Service, IRCCS Burlo Garofolo, Trieste, Italy
    AIDS 23:177-82. 2009
    ..The aim of our study was to verify the possible association between an HLA-G 14-bp deletion/insertion polymorphism and perinatal HIV transmission in Brazilian children...
  7. pmc Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain
    Laura L Baugh
    Y9 206, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Virol 82:9657-67. 2008
    ..Our results are consistent with an alternative model in which (62)EEEE(65) plays a stabilizing role in the formation of a ternary complex between Nef, the MHC-I cytoplasmic domain, and AP-1...
  8. doi Tolerance versus immune response -- microRNAs as important elements in the regulation of the HLA-G gene expression
    T D Veit
    Genetics Department, Post Graduation Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Transpl Immunol 20:229-31. 2009
    ....
  9. doi HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients
    Esther M de Kruijf
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 185:7452-9. 2010
    ..These results provide further evidence that breast cancer is immunogenic, but also capable of evading tumor eradication by the host's immune system, by up- or downregulation of HLA class Ia and class Ib loci...
  10. ncbi Association of soluble HLA-G plasma levels with HLA-G alleles
    V Rebmann
    Institute of Immunology, University Hospital of Essen, Essen, Germany
    Tissue Antigens 57:15-21. 2001
    ..Nevertheless, the existence of "low" and "high secretor" HLA-G alleles further suggests different levels of functionality in immune regulation...
  11. ncbi Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Immunol 160:3096-100. 1998
    ..ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity...
  12. doi The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells
    Edgardo D Carosella
    Commissariat a l Energie Atomique et aux Energies Alternatives Institute d Imagerie Biomedicale, Service de Recherches en Hemato Immunologie, Hopital Saint Louis, 1 Avenue Claude Vellejause, Paris Cedex, France
    Blood 118:6499-505. 2011
    ..In its second part, we highlight recent work that gathers individual effects and demonstrates how intertwined the HLA-G/myeloid APCs/regulatory cell relationship is...
  13. doi Expression of human leukocyte antigen-G in systemic lupus erythematosus
    Silvia Rosado
    Fundacion LAIR, Madrid, Spain
    Hum Immunol 69:9-15. 2008
    ..Despite the fact that patients present higher levels of HLA-G than healthy controls, which suggests a possible relevance of this molecule in SLE, it seems not to be related to IL-10 production or disease activity...
  14. pmc Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens
    A Ishitani
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104 2092
    Proc Natl Acad Sci U S A 89:3947-51. 1992
    ..These findings are discussed in terms of potential functions of the alternative HLA-G proteins...
  15. pmc Activation of NK cells by an endocytosed receptor for soluble HLA-G
    Sumati Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    PLoS Biol 4:e9. 2006
    ....
  16. doi Role of Nef in primate lentiviral immunopathogenesis
    F Kirchhoff
    Institute of Virology, University of Ulm, 89081 Ulm, Germany
    Cell Mol Life Sci 65:2621-36. 2008
    ..This evolutionary loss of a specific Nef function may contribute to the high virulence of HIV-1 in humans...
  17. ncbi The human amnion is a site of MHC class Ib expression: evidence for the expression of HLA-E and HLA-G
    J M Houlihan
    University of Bristol, Department of Obstetrics and Gynecology, St Michael s Hospital, UK
    J Immunol 154:5665-74. 1995
    ..Identification of the class Ib protein HLA-E in amnion epithelium may have implications for preterm labor that can be associated with infection of the placental membranes...
  18. pmc HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes
    J D Weissman
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:11601-6. 1998
    ..Thus, Tat repression of MHC class I transcription would be one mechanism by which HIV avoids immune surveillance...
  19. ncbi Expression of human leucocyte antigen G (HLA-G) is associated with prognosis in non-small cell lung cancer
    Shang mian Yie
    Chengdu Bioengineering Institute for Cancer Research, Chengdu, Sichuan, PR China
    Lung Cancer 58:267-74. 2007
    ..40-11.9). All in all, our results indicate that the expression of HLA-G is a characteristic feature of NSCLC, and they suggest that immunostaining by anti-HLA-G antibodies may be a potentially useful prognostic indicator...
  20. pmc A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells
    S Rajagopalan
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Exp Med 189:1093-100. 1999
    ..Therefore, given that HLA-G expression is restricted to fetal trophoblast cells, KIR2DL4 may provide important signals to maternal NK decidual cells that interact with trophoblast cells at the maternal-fetal interface during pregnancy...
  21. ncbi The 14 bp deletion-insertion polymorphism in the 3' UT region of the HLA-G gene influences HLA-G mRNA stability
    Philippe Rousseau
    Commissariat a l Energie Atomique, SRHI, IUH, Hopital St Louis 1, avenue Claude Vellefaux, Paris, France
    Hum Immunol 64:1005-10. 2003
    ....
  22. pmc The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    M E Greenberg
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    EMBO J 17:2777-89. 1998
    ....
  23. ncbi Functional role of human leukocyte antigen-G up-regulation in renal cell carcinoma
    Jürgen Bukur
    Third Department of Internal Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
    Cancer Res 63:4107-11. 2003
    ..Thus, aberrant HLA-G expression is found at a relatively high frequency in RCC and might participate in evasion of these tumor cells from immunosurveillance...
  24. ncbi Soluble HLA-G molecules are increased in lymphoproliferative disorders
    Yasmine Sebti
    Laboratoire Universitaire d Hématologie et la Biologie des Cellules Sanguines, UPRES EA 22 33, Faculte de Medecine, Universite de Rennes 1, Rennes, France
    Hum Immunol 64:1093-101. 2003
    ..The frequency of the sHLA-G secretion associated to its inhibiting role on T cells and natural killer cells during tumoral lymphoid malignancies suggests a potential role of these molecules as escape mechanism from antitumoral response...
  25. ncbi The short cytoplasmic tail of HLA-G determines its resistance to HIV-1 Nef-mediated cell surface downregulation
    Nathalie Pizzato
    Centre de Physiopathologie Toulouse Purpan, INSERM U563, Hopital Purpan, Toulouse, France
    Hum Immunol 65:1389-96. 2004
    ..This resistance may have functional consequences during the course of HIV infection...
  26. doi Characterization of HLA-G expression in renal cell carcinoma
    B L Li
    Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, China
    Tissue Antigens 74:213-21. 2009
    ..002), respectively. Our findings indicated that, except the papillary RCC, other types of RCC could express HLA-G. Furthermore, both lesion HLA-G expression and plasma sHLA-G level might be a useful preoperative biomarker for diagnosis...
  27. doi Behavior of non-classical soluble HLA class G antigens in human immunodeficiency virus 1-infected patients before and after HAART: comparison with classical soluble HLA-A, -B, -C antigens and potential role in immune-reconstitution
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Clin Immunol 133:238-44. 2009
    ....
  28. ncbi Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells
    Jennifer Hirst
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK
    Traffic 10:1696-710. 2009
    ..Thus, our results indicate that the two adaptors can function independently of each other...
  29. doi HLA-G 14-bp insertion/deletion polymorphism is a risk factor for HTLV-1 infection
    Rodrigo Haddad
    Hemocentro de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    AIDS Res Hum Retroviruses 27:283-8. 2011
    ..Although HLA-G 14-bp polymorphism does not appear to be associated with HTLV-1 related disease development, it could be a genetic risk factor for susceptibility to infection...
  30. pmc Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection
    Jun Zuo
    UCLA AIDS Institute and the David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    AIDS Res Hum Retroviruses 28:486-92. 2012
    ..Survival into adulthood with HIV infection acquired in infancy is not uniformly linked to loss of function in nef. The Nef protein remains a potential target for immunization or pharmacologic intervention...
  31. pmc A noncanonical mu-1A-binding motif in the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes
    Sayuki Iijima
    Laboratory of Disease Control, Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Hachimandai, Tsukuba shi, Ibaraki, Japan
    J Virol 86:3944-51. 2012
    ..Our findings will help understanding of how HIV-1 evades the antiviral immune response by selectively redirecting the cellular protein trafficking system...
  32. doi Human leukocyte antigen-G (HLA-G) expression in cervical cancer lesions is associated with disease progression
    Xiang Juan Li
    Department of Obstetrics and Gynecology, Huangyan Hospital, Wenzhou Medical College, Huangyan, Zhejiang, China
    Hum Immunol 73:946-9. 2012
    ..6% (45/84), 76.3% (29/38), and 100.0% (7/7), respectively. Taken together, our findings indicated that HLA-G expression was associated with the disease progression in patients with cervical cancer...
  33. doi Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy
    Irene Tirado-Gonzalez
    Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Medicine University Berlin, BMFZ, Raum 2 0547, Augustenburgerplatz 1, D 13353 Berlin, Germany
    Mol Hum Reprod 19:43-53. 2013
    ..Circulating gal-1 levels could serve as a predictive factor for pregnancy success in early human gestation...
  34. doi HLA-G 3' untranslated region 14-base pair deletion: association with poor survival in an HIV-1-infected Zimbabwean population
    Margit Hørup Larsen
    Department of Clinical Immunology, Copenhagen University Hospital Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    J Infect Dis 207:903-6. 2013
    ..004), lower CD4 cell count (P = .01), and increased mortality (hazard ratio, 1.9; 95% confidence interval, 1.033-3.522; P = .04) compared with HLA-G +14-bp carriers...
  35. ncbi Expression of human leukocyte antigen-G and its correlation with interleukin-10 expression in cervical carcinoma
    B S Yoon
    Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA University, Seoul, Korea
    Int J Gynaecol Obstet 98:48-53. 2007
    ..To determine human leukocyte antigen (HLA)-G and interleukin (IL)-10 expression and the relationship between HLA-G expression and clinicopathologic features in patients with cervical cancer...
  36. doi The 3'-untranslated region of the HLA-G gene in relation to pre-eclampsia: revisited
    M H Larsen
    Department of Clinical Biochemistry, Roskilde University Hospital, Roskilde, Denmark
    Tissue Antigens 75:253-61. 2010
    ....
  37. ncbi Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
    O Schwartz
    Laboratoire Rétrovirus et Transfert Génétique, Unité de Recherche Associée CNRS 1157, Paris, France
    Nat Med 2:338-42. 1996
    ..The stimulation of MHC-I endocytosis by Nef represents a previously undocumented viral mechanism for evading the immune response...
  38. ncbi Human neuroblastoma cells trigger an immunosuppressive program in monocytes by stimulating soluble HLA-G release
    Fabio Morandi
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Cancer Res 67:6433-41. 2007
    ....
  39. pmc Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action
    Jimmy D Dikeakos
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Biol Cell 21:3279-92. 2010
    ..Together, these studies resolve the seemingly controversial models that describe Nef-induced MHC-I down-regulation and provide new insights into the mechanism of Nef action...
  40. ncbi A class I antigen, HLA-G, expressed in human trophoblasts
    S Kovats
    Department of Human Oncology, University of Wisconsin, Madison 53706
    Science 248:220-3. 1990
    ..Expression of endogenous HLA-G genes has not been found in normal lymphoid cells. Thus, HLA-G is subject to both cell type-specific and developmental regulation and is expressed in early gestation human cytotrophoblasts...
  41. ncbi The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells
    F Navarro
    Servicio de Inmunologia, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Spain
    Eur J Immunol 29:277-83. 1999
    ..Our data demonstrate that NK recognition of cells expressing HLA-G1 involves at least two non-overlapping receptor-ligand systems: the CD94/NKG2 interaction with HLA-E, and the engagement of the ILT2(LIR1) receptor by HLA-G1 molecules...
  42. ncbi Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses
    Emanuele Fanales-Belasio
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Immunol 168:197-206. 2002
    ..Thus, Tat can act as both Ag and adjuvant, capable of driving T cell-mediated immune responses...
  43. pmc Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation
    S Le Gall
    Unité Rétrovirus et Transfert Génétique, URA CNRS 1930, France
    J Virol 74:9256-66. 2000
    ..Moreover, trafficking of A2-endo was still affected by the viral protein, indicating additive effects of prototypic signals and Nef. Therefore, distinct trafficking pathways regulate clathrin-dependent and Nef-induced MHC-I modulation...
  44. pmc HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice
    Katelyn M Atkins
    Vollum Institute, Portland, Oregon 97239, USA
    J Biol Chem 283:11772-84. 2008
    ..Together, these results demonstrate PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system...
  45. pmc A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment
    D E Geraghty
    Institute of Human Genetics, University of Minnesota, Minneapolis 55455
    Proc Natl Acad Sci U S A 84:9145-9. 1987
    ..Moreover, the promoter region of HLA-6.0 resembles the promoter region of a Qa region gene. These structural features of HLA-6.0 suggest that this non-HLA-A, -B, -C gene is a structural homolog of a murine Qa region class I gene...
  46. ncbi Detection of soluble HLA-G molecules in plasma and amniotic fluid
    V Rebmann
    Institute of Immunology, University Hospital of Essen, Germany
    Tissue Antigens 53:14-22. 1999
    ..This assay will facilitate the analysis of the biological and clinical significance of sHLA-G antigens in plasma...
  47. ncbi HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy
    Beatrice Fuzzi
    Department of Gynecology, Perinatal Medicine and Human Reproduction, University of Florence, Florence, Italy
    Eur J Immunol 32:311-5. 2002
    ..56 x 10(-3)). The results obtained indicate that expression of HLA-G products in embryo cells is a mandatory, but not sufficient, prerequisite for the development of pregnancy...
  48. ncbi Soluble HLA-G generated by proteolytic shedding inhibits NK-mediated cell lysis
    Gyu Man Park
    College of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    Biochem Biophys Res Commun 313:606-11. 2004
    ....
  49. ncbi Intrathecal synthesis of soluble HLA-G and HLA-I molecules are reciprocally associated to clinical and MRI activity in patients with multiple sclerosis
    E Fainardi
    Section of Neurology, Multiple Sclerosis Center, University of Ferrara, Arcispedale S Anna, Corso della Giovecca 203, Ferrara 1 44100, Italy
    Mult Scler 12:2-12. 2006
    ..Our results suggest that, in MS, a balance between classical sHLA-I and non-classical sHLA-G products modulating both MRI and clinical disease activity in opposite directions may exist...
  50. ncbi SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians
    R K Burfoot
    Howard Florey Institute, University of Melbourne, Melbourne, Victoria, Australia
    Tissue Antigens 71:42-50. 2008
    ..We have therefore identified plausible candidates for the causal MS susceptibility allele, and although not conclusive at this stage, our data provide suggestive evidence for multiple class I MS susceptibility genes...
  51. ncbi HLA-G in the skin--friend or foe?
    Mirjana Urosevic
    Department of Dermatology, University Hospital Zurich, 8091 Zurich, Switzerland
    Semin Cancer Biol 17:480-4. 2007
    ..This review focuses on the functionality of HLA-G in the skin and summarizes available data obtained from studies performed in skin cancer and inflammatory dermatoses...
  52. ncbi Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA Class I molecule
    S A Ellis
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    J Immunol 144:731-5. 1990
    ..0, which is the product of a class I locus other than A, B, or C, (provisionally designated "HLA G"). The expressed product of this locus has not previously been localized...
  53. ncbi Molecular studies of trophoblast HLA-G: polymorphism, isoforms, imprinting and expression in preimplantation embryo
    S E Hiby
    Department of Pathology, University of Cambridge, United Kingdom
    Tissue Antigens 53:1-13. 1999
    ..There was no evidence of imprinting. In addition we did not find mRNA for HLA-G in human two to eight-cell embryos or in blastocyst or in sperm samples...
  54. pmc HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
    V Piguet
    Department of Genetics and Microbiology, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland
    Nat Cell Biol 2:163-7. 2000
    ..These results support a model in which Nef relocalizes MHC-I by acting as a connector between MHC-I's cytoplasmic tail and the PACS-1-dependent protein-sorting pathway...
  55. ncbi Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function
    Tsufit Gonen-Gross
    Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Immunol 171:1343-51. 2003
    ..These oligomers, unique among the class I MHC proteins, probably bind to LIR-1 with increased avidity, resulting in an enhanced inhibitory function of LIR-1 and an impaired killing function of NK cells...
  56. ncbi HLA-G molecules: from maternal-fetal tolerance to tissue acceptance
    Edgardo D Carosella
    Service de Recherches en Hemato Immunologie, Direction des Sciences du Vivant, Departement de Recherche Medicale, CEA Commissariat à l Energie Atomique, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    Adv Immunol 81:199-252. 2003
    ..We review these points, with special emphasis on the role of HLA-G in human pathologies, such as cancer, viral infection, and inflammatory diseases, as well as in organ transplantation...
  57. ncbi Hypoxia does not reduce HLA-G expression on extravillous cytotrophoblasts
    Takeshi Nagamatsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    J Reprod Immunol 63:85-95. 2004
    ..Our findings demonstrate that no reduction of HLA-G was induced in CTs by short-term exposure to hypoxia, although further study may be required to find the effect of chronic hypoxia...
  58. ncbi Soluble HLA-G inhibits cell cycle progression in human alloreactive T lymphocytes
    Rajia Bahri
    Institut National de la Santé et de la Recherche Médicale Unité 542, Villejuif, France
    J Immunol 176:1331-9. 2006
    ..In contrast, it induced an accumulation of p27kip, but not p21cip, in activated T cells. HLA-G does not induce apoptosis of alloreactive T cells, but induces p27kip1 and inhibits cell cycle progression...
  59. ncbi Human leukocyte antigen-G, a new parameter in the follow-up of liver transplantation
    B Basturk
    Department of Internal Medicin Immunology Unit, Baskent University, Faculty of Medicine, Ankara, Turkey
    Transplant Proc 38:571-4. 2006
    ..Considering these results, we concluded that the increased sHLA-G in serum and on cell surfaces may afford preliminary data on the prognosis and response to treatment in liver transplant patients...
  60. ncbi Soluble HLA-G and HLA-G1 expressing antigen-presenting cells inhibit T-cell alloproliferation through ILT-2/ILT-4/FasL-mediated pathways
    Abderrahim Naji
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, Institut Universitaire d Hematologie, Paris, France
    Hum Immunol 68:233-9. 2007
    ..Evidence to support such role in vivo was provided by the capacity of purified HLA-G5 from the plasma of the transplanted patient to suppress T-cell alloresponses...
  61. ncbi Human decidual stromal cells express HLA-G: Effects of cytokines and decidualization
    Osmany Blanco
    Departamento de Bioquimica, Biología Molecular 3 e Inmunología, Facultad de Medicina, Unidad de Inmunologia, Instituto de Biopatologia y Medicina Regenerativa, Universidad de Granada, 18012 Granada, Spain
    Hum Reprod 23:144-52. 2008
    ..HLA-G, an antigen preferentially expressed by trophoblast, appears to participate in the immune tolerance by the mother of the semiallogeneic fetus...
  62. doi Human leukocyte antigen-G, a ligand for the natural killer receptor KIR2DL4, is expressed by eutopic endometrium only in the menstrual phase
    Masaaki Kawashima
    Department of Obstetrics and Gynecology, Kochi Medical School, Nankoku, Kochi, Japan
    Fertil Steril 91:343-9. 2009
    ..Such antigens have been linked to endometriosis...
  63. doi Beyond the increasing complexity of the immunomodulatory HLA-G molecule
    Edgardo D Carosella
    CEA, IBM, Service de Recherches en Hemato Immunologie, Paris, France
    Blood 111:4862-70. 2008
    ..We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant...
  64. doi Expression and regulation of non-classical HLA-G in renal cell carcinoma
    K Dunker
    Martin Luther University Halle Wittenberg, Institute of Medical Immunology, Halle Saale, Germany
    Tissue Antigens 72:137-48. 2008
    ..Thus, there exist multiple mechanisms controlling HLA-G expression in RCC, which might also have an impact on the development of RCC-specific immunotherapies...
  65. pmc HLA-G: a human pregnancy-related immunomodulator
    Joan S Hunt
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS, United States
    Curr Opin Pharmacol 9:462-9. 2009
    ....
  66. doi Human leukocyte antigen-G is expressed in advanced-stage ovarian carcinoma of high-grade histology
    Catherine Menier
    CEA, I2 BM, Service de Recherches en Hemato Immunologie, Paris, France
    Hum Immunol 70:1006-9. 2009
    ..For this purpose, we looked for HLA-G expression in ovarian carcinoma lesions from low to high grade and stage, and we showed that HLA-G is selectively expressed in advanced-stage disease of high-grade histology...
  67. doi HLA-G 3'-UTR SNP and 14-bp deletion polymorphisms in Portuguese and Guinea-Bissau populations
    M Alvarez
    Department of Anthropology, University of Coimbra, 3000 056 Coimbra, Portugal
    Int J Immunogenet 36:361-6. 2009
    ..The screening for sequence motifs suggests that polymorphism on this region may be involved in HLA-G post-transcriptional regulation and, therefore, in phenotype variation...
  68. doi RREB-1 is a transcriptional repressor of HLA-G
    Sébastien Flajollet
    Commissariat a l Energie Atomique, Direction des Sciences du Vivant, IBM, Service de Recherches en Hemato Immunologie, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    J Immunol 183:6948-59. 2009
    ..This demonstration is the first of a repressor factor of HLA-G transcriptional activity taking part in HLA-G repression by epigenetic mechanisms...
  69. doi Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway
    Silvia Gregori
    Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy
    Blood 116:935-44. 2010
    ..Our data indicate that DC-10 represents a novel subset of tolerogenic DCs, which secrete high levels of IL-10, express ILT4 and HLA-G, and have the specific function to induce Tr1 cells...
  70. pmc Ex vivo functional responses to HLA-G differ between blood and decidual NK cells
    Richard Apps
    Department of Pathology and Center for Trophoblast Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Mol Hum Reprod 17:577-86. 2011
    ..These findings should be considered when inferring the activity of tissue NK cells from results obtained with cell lines, peripheral NK or cultured dNK cells...
  71. doi Plasma soluble HLA-G is a potential biomarker for diagnosis of colorectal, gastric, esophageal and lung cancer
    M Cao
    Core Laboratory, Sichuan Academy of Medical Sciences, Chengdu, Sichuan, PR China
    Tissue Antigens 78:120-8. 2011
    ..These findings suggest that plasma sHLA-G may be a useful molecule in the differential diagnosis of these malignancies against healthy controls...
  72. pmc HLA-G polymorphisms and soluble HLA-G protein levels in women with recurrent pregnancy loss from Basrah province in Iraq
    Raghed M Jassem
    Basic Science Department, Dentistry College, University of Basrah, Basrah, Iraq
    Hum Immunol 73:811-7. 2012
    ..1 vs. 40.1 vs. 42.6 U/ml, respectively; P=0.0089). These results demonstrate that HLA-G genotype influences circulating sHLA-G levels during pregnancy but is not significantly associated with risk of RPL...
  73. doi Role of HLA-G 14bp deletion/insertion and +3142C>G polymorphisms in the production of sHLA-G molecules in relapsing-remitting multiple sclerosis
    Roberta Rizzo
    Department of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, Ferrara 44121, Italy
    Hum Immunol 73:1140-6. 2012
    ..Our preliminary findings suggest that serum and CSF sHLA-G levels in MS could be influenced by HLA-G polymorphisms irrespective of the inflammatory microenvironment...
  74. pmc LINE1 family member is negative regulator of HLA-G expression
    Masashi Ikeno
    School of Medicine, Keio University, Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nucleic Acids Res 40:10742-52. 2012
    ..The presence of a LINE1 gene silencer may explain the limited expression of HLA-G compared with other class I genes...
  75. pmc Immunomodulatory molecules are released from the first trimester and term placenta via exosomes
    S K Kshirsagar
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Placenta 33:982-90. 2012
    ....
  76. pmc Human leukocyte antigen-G is frequently expressed in glioblastoma and may be induced in vitro by combined 5-aza-2'-deoxycytidine and interferon-γ treatments: results from a multicentric study
    Isabela J Wastowski
    Commissariat à l Énergie Atomique et aux Énergies Alternatives, Institut des Maladies Emergentes et des Thérapies Innovantes, Service de Recherches en Hemato Immunologie, Hopital Saint Louis, Paris, France
    Am J Pathol 182:540-52. 2013
    ....
  77. doi Role of human leukocyte antigen-G 14-base pair polymorphism in kidney transplantation outcomes
    Roberto Littera
    Regional Government Reference Center for Organ, Tissue and Cell Transplantation, R Binaghi Hospital ASL 8, Cagliari Italy
    J Nephrol 26:1170-8. 2013
    ..The 14-base pair (14-bp) polymorphism in the 3'-untranslated region of the HLA-G gene is thought to have a role in soluble HLA-G (sHLA-G) expression...
  78. doi Association of HLA-G promoter and 14-bp insertion-deletion variants with acute allograft rejection and end-stage renal disease
    M K Misra
    Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
    Tissue Antigens 82:317-26. 2013
    ..43 U/ml) as compared to controls (mean ± SEM; 21.06 ± 3.89 U/ml) (P = <0.0001). The 14-bp I/I, 14-bp I/D and 14-bp D/D genotypes showed significantly higher levels of sHLA-G among non-AR as compared to AR patients. ..
  79. doi NK resistance of tumor cells from multiple myeloma and chronic lymphocytic leukemia patients: implication of HLA-G
    G Maki
    Section of Hematology and Bone Marrow Transplantation, Division of Hematology Oncology, Rush University Medical Center, Chicago, IL, USA
    Leukemia 22:998-1006. 2008
    ....
  80. pmc An alternatively spliced form of HLA-G mRNA in human trophoblasts and evidence for the presence of HLA-G transcript in adult lymphocytes
    M Kirszenbaum
    Commissariat a l Energie Atomique, Hôpital Saint Louis Centre Hayem, Paris, France
    Proc Natl Acad Sci U S A 91:4209-13. 1994
    ..These results are discussed in the context of the fetal-maternal relationship presented by HLA-G gene products...
  81. ncbi Cutting edge: soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8
    S Fournel
    Institut National de la Santé et de la Recherche Médicale INSERM U395, Hopital de Purpan, Toulouse, France
    J Immunol 164:6100-4. 2000
    ..Finally, we show that such sHLA-G1-induced apoptosis depends on the interaction with CD8 molecules, with cell death being blocked by various CD8 mAbs...
  82. ncbi Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation
    B Peng
    Basic Research Laboratory, National Cancer Institute, National Institutes of Health, 41 Libary Drive, Building 41 Room d804, Bethesda, MD 20892 5055, USA
    Immunol Lett 78:195-200. 2001
    ..Non-myristoylated Nef containing a full complement of CTL epitopes has greater potential as a vaccine component than wild-type Nef...
  83. ncbi Detection of HLA-G in serum and graft biopsy associated with fewer acute rejections following combined liver-kidney transplantation: possible implications for monitoring patients
    Caroline Creput
    Service de Recherches en Hemato Immunologie, Hopital Saint Louis, IUH, Paris, France
    Hum Immunol 64:1033-8. 2003
    ....
  84. ncbi Express and protect yourself: the potential role of HLA-G on muscle cells and in inflammatory myopathies
    Heinz Wiendl
    Department of Neurology, University of Tubingen, Tubingen, Germany
    Hum Immunol 64:1050-6. 2003
    ..We further speculate on the potential therapeutic implications of HLA-G that relate to special approaches such as myoblast transplantation or strategies against inflammatory aggression in general...
  85. ncbi HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells
    Joel Lemaoult
    Service de Recherches en Hemato Immunologie, Commissariat à L Energie Atomique DRM DSV, Institut Universitaire d Hematologie, Hopital Saint Louis, Paris, France
    FASEB J 19:662-4. 2005
    ..Functionally, up-regulation of inhibitory receptors in immune cells before stimulation might increase their activation thresholds and participate in immune escape mechanisms...
  86. doi Association of the HLA-G 14 bp polymorphism with systemic lupus erythematosus
    T D Veit
    Genetics Department, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Brazil
    Lupus 18:424-30. 2009
    ..Overall, our results support the idea of a role of the HLA-G insertion/deletion polymorphism and therefore a role for the HLA-G molecule, on the pathology of SLE...
  87. ncbi Production of sHLA-G molecules by in vitro matured cumulus-oocyte complex
    Roberta Rizzo
    Department of Experimental and Diagnostic Medicine, Laboratory of Immunogenetics, University of Ferrara, 46 44100 Ferrara, Italy
    Int J Mol Med 24:523-30. 2009
    ..This non-invasive marker could be used, in addition to morphological approaches, to reduce the number of fertilized oocytes and transferred embryos...
  88. doi HLA-G and HLA-E in patients with juvenile idiopathic arthritis
    Ignazia Prigione
    Laboratory of Oncology, G Gaslini Scientific Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Rheumatology (Oxford) 50:966-72. 2011
    ..To investigate the expression and release of HLA-G and HLA-E in JIA...
  89. doi Association of HLA-G 3' untranslated region polymorphisms with antibody response against Plasmodium falciparum antigens: preliminary results
    A Sabbagh
    Institut de Recherche pour le Developpement, UMR 216 Mère et Enfant face aux infections tropicales, Paris, France
    Tissue Antigens 82:53-8. 2013
    ..While these results require further investigation, they suggest for the first time a role of HLA-G in the regulation of humoral immune response in malaria...
  90. pmc HLA-G expression in melanoma: a way for tumor cells to escape from immunosurveillance
    P Paul
    Direction des Sciences du Vivant Department de Recherche Medicale, Service de Recherches en Hemato Immunologie, Commissariat a l Energie Atomique, Hopital Saint Louis, Centre Hayem, 1, avenue Claude Vellefaux, 75010 Paris, France
    Proc Natl Acad Sci U S A 95:4510-5. 1998
    ..It thus appears of critical importance to consider the specific role of HLA-G expression in tumors in the design of future cancer immunotherapies...
  91. ncbi HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway
    S A Swann
    Departments of Medicine and Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Virology 282:267-77. 2001
    ..We propose that Nef diverts MHC-1 proteins into a PI 3-kinase-dependent transport pathway that prevents expression on the cell surface...
  92. ncbi HLA-G transactivation by cAMP-response element-binding protein (CREB). An alternative transactivation pathway to the conserved major histocompatibility complex (MHC) class I regulatory routes
    Sam J P Gobin
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    J Biol Chem 277:39525-31. 2002
    ..This implies a unique regulation of HLA-G transcription among the MHC class I genes...
  93. pmc HLA-G gene repression is reversed by demethylation
    Philippe Moreau
    Commissariat a l Energie Atomique, Service de Recherche en Hémato Immunologie, Direction des Sciences du Vivant Department de Recherche Medicale, Institut Universitaire d Hematologie, Hopital Saint Louis, 75010 Paris, France
    Proc Natl Acad Sci U S A 100:1191-6. 2003
    ..Reversal of methylation-mediated repression may directly induce HLA-G cell-surface expression, supporting the idea that HLA-G might be activated by such a mechanism during malignancy, inflammation, and allogenic reactions...
  94. pmc Variation in the HLA-G promoter region influences miscarriage rates
    Carole Ober
    Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA
    Am J Hum Genet 72:1425-35. 2003
    ....
  95. ncbi Expression of HLA-G in human cornea, an immune-privileged tissue
    Magali Le Discorde
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Institut d Hematologie, Hopital Saint Louis, Paris, France
    Hum Immunol 64:1039-44. 2003
    ..The detection of HLA-G protein in adult corneas leads to the conclusion that this protein may contribute to the maintenance of the privileged immune status of cornea...
  96. ncbi Analysis of HLA antigen expression in benign and malignant melanocytic lesions reveals that upregulation of HLA-G expression correlates with malignant transformation, high inflammatory infiltration and HLA-A1 genotype
    El Cherif Ibrahim
    CEA, Service de Recherches en Hemato Immunologie, DSV DRM, Hopital Saint Louis, Institut d Hematologie, Paris, France
    Int J Cancer 108:243-50. 2004
    ..These findings may provide new insights in the comprehension of tumor progression and design of therapeutic approaches aimed at enhancing antitumor immune responses in melanoma patients...
  97. ncbi Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome
    T V F Hviid
    Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen Ø, Denmark
    Tissue Antigens 64:66-9. 2004
    ..This might affect a possible immunomodulatory role of HLA-G expression in both the mother and foetus during implantation and pregnancy...
  98. ncbi Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis
    Catherine Menier
    Service de Recherches en Hemato Immunologie, CEA DSV DRM, Hopital Saint Louis, IUH, 1, avenue Claude Vellefaux, 75010 Paris, France
    Blood 104:3153-60. 2004
    ..This new marker, previously known by its immunotolerogeneic properties, may be involved in erythroid differentiation, angiogenesis, or both...
  99. ncbi Analysis of human leukocyte antigen (HLA)-G polymorphism in normal women and in women with recurrent spontaneous abortions
    A Abbas
    Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Eur J Immunogenet 31:275-8. 2004
    ..The frequency of the null allele G*0105N was high (13.8%) in our population as compared to other world populations. Our data support the hypothesis that HLA-G polymorphism may contribute to recurrent foetal loss...
  100. ncbi HLA-G polymorphism in a Chinese Han population with recurrent spontaneous abortion
    W H Yan
    Laboratory of Immunogenetics, Shanghai Second Medical University, Shanghai Institute of Immunology, Shanghai 200025, China
    Int J Immunogenet 33:55-8. 2006
    ..The frequency of the null allele HLA-G*0105 N in the RSA group and in normal fertile women is 0.7% and 1.4%, respectively. Our data suggested that there was no association of HLA-G polymorphism with RSA...
  101. ncbi Regulatory role of tryptophan degradation pathway in HLA-G expression by human monocyte-derived dendritic cells
    Ana S López
    Department of Clinical Biochemistry, Clinica Universitaria de Navarra, Av Pio XII 36, 31008 Pamplona, Spain
    Mol Immunol 43:2151-60. 2006
    ..These results suggest that IDO can induce HLA-G cell surface expression in DC, and that these two molecules can cooperate in the immune suppression...

Research Grants64

  1. Robust Generalization in MHC Peptide Binding Models
    Pedro Cano; Fiscal Year: 2002
    ....
  2. HLA-G AND EQUIVALENT AND FETO-MATERNAL INTERACTION
    Hidde Ploegh; Fiscal Year: 2003
    ....
  3. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..abstract_text> ..
  4. Jack L Strominger; Fiscal Year: 2014
    ....
  5. ROBERT MICHAEL ROBERTS; Fiscal Year: 2015
    ..Also by generating such pluripotent cells from umbilical cords of babies born to mothers that developed pre-eclampsia, we hope to recreate the cell type that caused the disease in the first place. ..
  6. Functional Analysis of PAAN-AG5, the Baboon Counterpart of HLA-G5
    Daudi K Langat; Fiscal Year: 2010
    ..This proposal is aimed at assessing the feasibility of using the olive baboon as a model for HLA-G in vivo experiments. ..
  7. COMPARATIVE STUDIES OF PREGNANCY AND HISTOCOMPATIBILITY
    DOUGLAS ANTCZAK; Fiscal Year: 2000
    ..Additionally, they may reveal important links between the behavior of the fetal allograft and its maternal host and the success and failure of tumors and clinical organ transplants. ..
  8. Mechanisms of NK Cell Activation by the KIR2DL4 Receptor
    Kerry Campbell; Fiscal Year: 2009
    ..What is the mechanism of Fc[unreadable]RI-[unreadable]-independent signaling by KIR2DL4? Aim 3. Characterization of novel KIR2DL4 ligand(s) on transformed epithelial and fibroblast cells ..
  9. CLASS I MHC GENES EXPRESSED BY HUMAN TROPHOBLAST CELLS
    JOAN HUNT; Fiscal Year: 1999
    ..We expect the results of this research to shed considerable light on crucial issues of HLA-related fertility and reproduction. ..
  10. Role of epithelial HLA-G in lung transplantation
    Steven R White; Fiscal Year: 2010
    ....
  11. UTERINE NK CELLS IN PRIMATE PREGNANCY
    Thaddeus G Golos; Fiscal Year: 2010
    ..for an important role of placental MHC class I molecules in the maternal immunological response to pregnancy in primates, and will further study the mechanisms and significance of these responses with two specific aims: ..
  12. SOLUBLE ISOFORMS OF HLA-G: STRUCTURE, REGULATION AND FUNCTION
    JOAN SHERAR HUNT; Fiscal Year: 2011
    ..We expect here to provide entirely novel information that is essential to the design of therapeutic strategies to address HLA-G-associated pathologies of pregnancy. ..
  13. Thaddeus G Golos; Fiscal Year: 2014
    ....
  14. A Primate Model of Maternal Fetal Immune Tolerance
    Thaddeus Golos; Fiscal Year: 2006
    ..The successful implementation of our recent adaptation of transgenic technology to the primate placenta will provide unprecedented opportunity for novel models of primate placental biology. ..
  15. Carole Ober; Fiscal Year: 2016
    ..abstract_text> ..
  16. N-3 PUFAs and antigen presenting cells
    Saame R Shaikh; Fiscal Year: 2010
    ..This grant proposal aims to test a new model on how n-3 PUFAs modify the function of specific immune cells. Data generated from this proposal will contribute to the development n-3 PUFAs as nutraceuticals. ..
  17. PEPTIDE BASED DELIVERY OF HIV IMMUNOGEN
    Lee Riley; Fiscal Year: 1999
    ..While this may be a high risk project, the yield, if shown to work, even as a method to enhance mammalian cell delivery of proteins, should have a significant impact. ..
  18. MHC Class I Antigen Presentation in Viral Infections
    Luis J Sigal; Fiscal Year: 2011
    ..These experiments should provide important information to understand the pathogenesis of viral infections and the induction of anti-viral CD8+ T cell responses. ..
  19. Beta 2-Microglobulin signaling and targeting in bone metastasis
    Leland W K Chung; Fiscal Year: 2013
    ..This project focuses on defining the molecular mechanism of this synergism and the appropriate preclinical studies to move these discoveries from bench to the bedside. ..
  20. PROTO ONCOGENE PML AND TUMOR EVASION OF HOST IMMUNITY
    Pan Zheng; Fiscal Year: 2002
    ..As such, our study may establish PML as a master regulator controlling MHC class I antigen presentation. ..
  21. Craig A Elmets; Fiscal Year: 2014
    ..We have developed novel reagents and we utilize them as a vaccine to determine if they augment immunity to PAHs and can be used to prevent tumors from developing in the first place. ..
  22. Primate Endometrial Responses to Placental MHC Class I Molecules
    Thaddeus Golos; Fiscal Year: 2009
    ....
  23. Aneuploid Cells in the Human Placenta
    Heinz Ulrich Weier; Fiscal Year: 2006
    ..We will also have detailed information about the frequency, localization and types of aneuploid cells at the fetal-maternal interface and the effects of aneuploidy on CTB proliferation and HLA-G gene expression. ..
  24. EXPRESSION & FUNCTION OF THREE NEW HLA CLASS I ANTIGENS
    Daniel Geraghty; Fiscal Year: 1993
    ..b) We will concentrate on the T cell reactivity of the soluble HLA-G protein by attempting to measure it's effect on normal T cell function in vitro...
  25. Evasion of antiviral protection by poxvirus-encoded interferon antagonists
    Sergei V Kotenko; Fiscal Year: 2010
    ....
  26. Julian Solway; Fiscal Year: 2015
    ....
  27. Heteroclitic and modified T cell epitopes in coronavirus encephalomyelitis
    Jonathan A Trujillo; Fiscal Year: 2012
    ..This approach will be useful in design of vaccines that are directed at enhancing pathogen-specific CD8 T cell responses. ..
  28. IMMUNOBIOLOGY OF MHC RESTRICTION OF T-CELLS
    Kenneth L Rock; Fiscal Year: 2013
    ..The information gained by the proposed studies may lead to a better ability to predict and monitor immune responses to viruses and cancers and ultimately aid in the development of vaccines for these diseases. ..
  29. Potential of HLA-G for transplantation
    Anatolij Horuzsko; Fiscal Year: 2009
    ..of immune responses and will aid in development of novel strategies for translation into the clinic to improve allograft survival in patients and treat graft-versus-host disease, allergy, and autoimmune diseases ..
  30. HLA-G - LILRB - SHP2 Axis in Airway Smooth Muscle
    Julian Solway; Fiscal Year: 2012
    ..abstract_text> ..
  31. The Endogenous MHC Class I Antigen Processing Pathway
    Nilabh Shastri; Fiscal Year: 2012
    ..We anticipate that this research will improve our understanding of the mechanisms by which the immune system detects infected cells and tumors as well as self-tissues in autoimmunity. ..
  32. Immune surveillance via non-classical MHC class Ib molecules
    Nilabh Shastri; Fiscal Year: 2013
    ....
  33. Calreticulin's functions in the adaptive immune response
    Malini Raghavan; Fiscal Year: 2010
    ..Understanding the molecular mechanisms of calreticulin's functions, and elucidation of conditions that enhance calreticulin's T cell priming activities, will facilitate more effective design of vaccines. ..
  34. RECOMBINANT LISTERIA VACCINES FOR MELANOMA
    JEFFERY MILLER; Fiscal Year: 2003
    ..monocytogenes. L. innocua is a non-pathogenic member of the Listeria genus. By transferring genes from L. monocytogenes, we will attempt to construct chimeric strains that are immunogenic yet avirulent. ..
  35. Glucocorticoid/Stress Effects on Dendritic Cell Function
    Robert H Bonneau; Fiscal Year: 2010
    ..abstract_text> ..
  36. PERTUSSIS TOXIN TRANSPORT IN CELLS AND EPITOPE DELIVERY
    NICHOLAS CARBONETTI; Fiscal Year: 2000
    ..The advantages of PT* as a vaccine vector include its potent adjuvant-icity and its safety and non-reactogenicity for humans, being a component of a licensed pertussis vaccine. ..
  37. HEREDITARY HEMOCHROMATOSIS
    JAMES KUSHNER; Fiscal Year: 2001
    ..Three specific aims are proposed: Aim 1: using an animal model of hemochromatosis in which the b2 microglobulin gene has been knocked out, small intestinal and bone marrow transplantation studies between (b2m -/-) and wt ..
  38. LOWER VERTEBRATE IMMUNOGLOBULIN AND B2-MICROGLOBULIN
    GARY LITMAN; Fiscal Year: 1980
    ..The possible relationship of these polypeptides to the membrane components known to be products of the major histocompatibility complex in higher vertebrates will be examined. ..
  39. SYNOVIOCYTES AND B2 MICROGLOBULIN AMYLOIDOSIS
    Sharon Moe; Fiscal Year: 1999
    ..Beta2M isolated from patients with acute renal failure and chronic renal failure with and without beta2M amyloidosis will be utilized. ..
  40. CHEMICAL GENETIC & CELLULAR ASPECTS OF IMMUNOGENICITY
    Thomas Gill; Fiscal Year: 1992
    ....
  41. Selegiline, Oxidative Stress and MRS in HIV Dementia
    Giovanni Schifitto; Fiscal Year: 2003
    ..and with established predictors of HIV-associated cognitive impairment including CSF HIV RNA (viral load) and B2 microglobulin levels...
  42. HLA-B27 Misfolding in Spondyloarthropathy Pathogenesis
    Robert Colbert; Fiscal Year: 2005
    ....
  43. HLA G TEST FOR RUPTURE OF MEMBRANES AND PRETERM DELIVERY
    Simon Shorter; Fiscal Year: 2000
    ..proposed commercial application: not available ..
  44. IFN GAMMA-TREATED PANCREATIC BETA-CELLS
    H Gaskins; Fiscal Year: 1999
    ..Collectively, these studies will define molecular mechanisms likely operative in the prediabetic beta-cell, thereby providing information critical for bridging the gap between diagnosis and treatment of IDDM. ..
  45. Antisense Mutants of M. Tuberculosis
    DOUGLAS KERNODLE; Fiscal Year: 2004
    ..tuberculosis. The findings from this work will help to optimize vaccine efficacy and may also expand our diagnostic capacity to distinguish prior vaccination from tuberculosis infection...
  46. Chaperone-based tumor therapy delivered by viral vectors
    Michael Green; Fiscal Year: 2003
    ..At VirRx, we will test the efficacy of the W-GRP94 vectors for the induction of anti-tumor immunity using in vivo murine tumor models. ..
  47. Enhancing CD8 T-cell immunity against coxsackievirus B3
    CHRISTOPHER CORNELL; Fiscal Year: 2006
    ..Viable viruses harboring the mutations found in Specific Aim 1 will be utilized in vaccination/challenge: studies in mice. ..
  48. OPTIMAL DELIVERY OF TWO SIGNALS TO ENHANCE ANTI-HIV CTL
    Yang Liu; Fiscal Year: 2001
    ..Should co-delivery of signals 1 and 2 induce better protection, then an expanded proposal will be submitted to evaluate the potential of this approach in the development of a vaccine for HIV/SIV infection in primates and humans. ..
  49. ANTIBODY DEPENDENT CELL CYTOTOXICITY REACTIONS
    MICHAEL FANGER; Fiscal Year: 1980
    ..Moreover, some of the information obtained may provide insights into in vivo approaches to the modulation of ADCC reactivity. ..
  50. CTL INDUCTION STRATEGIES FOR AIDS VACCINES
    Richard Young; Fiscal Year: 2002
    ..Norman Letvin (Subcontract with Beth Israel Deaconess Medical Center), and for protection against a live challenge with SIV in collaboration with Dr. Michael Wyand (Subcontract with GTC Mason Laboratories). ..
  51. Propeptide Mediation of Immunoproteasome Assembly
    Thomas Griffin; Fiscal Year: 2006
    ..abstract_text> ..
  52. GLYCOCONJUGATE-INDUCED TOLERANCE IN NATURAL KILLER CELLS
    Gary Clark; Fiscal Year: 2002
    ..The primary goal of this study is to carry out experiments complementing preliminary studies in support of this glycoconjugate-based model. ..
  53. An MHC Approach to Antiviral Vaccines
    GEORGE KITTO; Fiscal Year: 2002
    ..These epitopes were chosen because of their highly conserved nature, their cross-clade reactivity, and their role in the spread of the disease. ..
  54. MOLECULAR MECHANISMS OF MHC CLASS I ANTIGEN RECOGNITION
    Matthew Mescher; Fiscal Year: 2001
    ....
  55. POLYMORPHIC NEURONAL SURFACE PROTEINS
    LOIS LAMPSON; Fiscal Year: 1991
    ..In later studies, we will determine the nature of possible polymorphisms (cell to cell, tissue to tissue, etc.) of new HIBIT proteins; this will suggest the type of recognition function each might serve...
  56. Role of Interferon-lambda in Antiviral Response
    Sergei Kotenko; Fiscal Year: 2009
    ..abstract_text> ..
  57. INDUCING APOPTOSIS TO AUGMENT CROSS-PRIMING FOR CTL
    Ann Hill; Fiscal Year: 2001
    ..The monkeys will be assessed for CTL numbers after DNA vaccination; they will then be boosted with a poxvirus expressing nef and challenged with virulent SIV. ..
  58. New approach to T cell study for Vaccine in Uganda
    Huyen Cao; Fiscal Year: 2005
    ..We will introduce the use of LFn-HIV of multiple clades (A, B and D) and assess the level of cross-clade activity in this population using both ELIspot and flow based cytometry. ..
  59. Immunofluorescent 3D-analysis of NK-target conjugates
    Yatin Vyas; Fiscal Year: 2006
    ..Such analysis will improve our understanding of the biology of cytolytic effector lymphocytes that could be of potential use in immunotherapy. ..
  60. HLA-G AND MATERNAL/PLACENTAL IMMUNE FUNCTION
    Daniel Geraghty; Fiscal Year: 1999
    ..We will further examine HLA-G function by comparing the ability of soluble and membrane HLA-G to suppress maternal NK activity. ..
  61. HIV Evasion of CTL and NK cells by HLA-G
    Edward Barker; Fiscal Year: 2004
    ..abstract_text> ..
  62. Potential of HLA-G for transplantation
    Anatolij Horuzsko; Fiscal Year: 2007
    ..abstract_text> ..
  63. HLA-G AND MATERNAL/FETAL IMMUNE INTERACTIONS
    Harry Orr; Fiscal Year: 1999
    ..Finally, the role of HLA-G expressed at the maternal/fetal interface in presenting foreign antigen to the maternal immune system will be assessed. ..