Genomes and Genes
Gene Symbol: HLA DQA1
Description: major histocompatibility complex, class II, DQ alpha 1
Alias: CELIAC1, DQ-A1, HLA-DQA, HLA class II histocompatibility antigen, DQ alpha 1 chain, DC-1 alpha chain, DC-alpha, HLA-DCA, MHC HLA-DQ alpha, MHC class II DQA1, MHC class II HLA-DQ-alpha-1
Publications253 found, 100 shown here
- HLA-DQA1*0501 is associated with diffuse systemic sclerosis in Caucasian menN C Lambert
Immunogenetics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Arthritis Rheum 43:2005-10. 2000..In the current study, we investigated HLA class II alleles in men with SSc. We also investigated the hypothesis that HLA compatibility of the mother could be a risk factor for SSc in men...
- Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian womenP C Maciag
Department of Genetics, Federal University of Parana, Curitiba, Brazil
Cancer Epidemiol Biomarkers Prev 9:1183-91. 2000..48; 95% CI, 1.06-5.80). We suggest that HLA class II polymorphisms are involved in genetic susceptibility to cervical cancer and HPV infection in a Brazilian population from an area with a high incidence of this neoplasia...
- Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibilityMatthew R Lincoln
University Department of Clinical Neurology, Third Floor, West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
Proc Natl Acad Sci U S A 106:7542-7. 2009..MHC disease associations may be more generally haplotypic or diplotypic...
- Common variants on chromosome 6p22.1 are associated with schizophreniaJianxin Shi
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
Nature 460:753-7. 2009..These results demonstrate that common schizophrenia susceptibility alleles can be detected. The characterization of these signals will suggest important directions for research on susceptibility mechanisms...
- IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian populationFolefac Aminkeng
Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium
Hum Immunol 70:706-10. 2009..76, p = 0.19) and no interaction with HLA-DQ-linked risk. Furthermore, no genotype-phenotype correlation was observed. In conclusion, IFIH1 has no important role in T1D risk assessment in a registry-based Belgian population...
- HLA-Class II in Latin American patients with type 1 diabetesAdriana Rojas-Villarraga
Center for Autoimmune Diseases Research, Universidad del Rosario, Bogota, Colombia
Autoimmun Rev 9:666-73. 2010..To identify and estimate the common effect size of HLA-Class II contributing to susceptibility on T1D in Latin America (LA) through a meta-analysis...
- Leprosy and the adaptation of human toll-like receptor 1Sunny H Wong
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
PLoS Pathog 6:e1000979. 2010..These observations provide insight into the long standing host-pathogen relationship between human and mycobacteria and highlight the key role of the TLR pathway in infectious diseases...
- Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk lociJason D Cooper
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Nat Genet 40:1399-401. 2008..7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8))...
- Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infectionRae Anne Hardie
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
AIDS 22:807-16. 2008..To determine the association of DQ antigens with resistance and susceptibility to HIV-1...
- Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered riskSabina Resic-Lindehammer
Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC Lund University, Ent 72 Bldg 91 Floor 10, 205 02 Malmo, Sweden
Acta Diabetol 45:231-5. 2008..The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to ..
- Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controlsLiene Nikitina-Zake
Immunogenetics, Molecular Medicine, L8 00, Karolinska Hospital, Karolinska Institutet, 17176 Stockholm, Sweden
Ann N Y Acad Sci 1037:161-9. 2004..3), was higher. The maximum risk was when KIR2DL2, MICA5, and DR3/DR4 were in combination. In conclusion, our results suggest that a balance between innate and acquired immunity is important, and an imbalance coud lead to T1DM...
- Diabetes-specific HLA-DR-restricted proinflammatory T-cell response to wheat polypeptides in tissue transglutaminase antibody-negative patients with type 1 diabetesMajid Mojibian
Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada
Diabetes 58:1789-96. 2009..However, questions arise regarding the frequency of abnormal immune responses to wheat and their nature, and it remains unclear whether such responses are diabetes specific...
- HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics ConsortiumJanelle A Noble
Children s Hospital Oakland Research Institute, Oakland, California, USA
Diabetes 59:2972-9. 2010..We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study...
- Polymorphisms of CXCR3-binding chemokines in type 1 diabetesPatrick Bruck
Department of Internal Medicine IV, Division of Haematology and Oncology, University Hospital Giessen and Marburg, Germany
Hum Immunol 70:552-5. 2009..Although we did not find an association of the CXCL9 and CXCL10 polymorphisms with type 1 diabetes in the German population, we cannot discard their role in other populations or other autoimmune diseases...
- The rare HLA-DQA1*03-DQB1*02 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjectsJan E van Autreve
Diabetes Research Center, Molecular Diagnosis, Vrije Universteit Brussel, B 1070 Brussels, Belgium
Hum Immunol 65:729-36. 2004..These results are compatible with an effect of cis-encoded heterodimers or with previously suggested interactions of X-linked genetic factors with (DR3-)DQB1*02 haplotypes...
- HLA-DR-DQ haplotypes and type 1 diabetes in MacedoniaJorma Ilonen
Immunogenetics Laboratory, University of Turku, Turku, Finland
Hum Immunol 70:461-3. 2009....
- An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphismsLars C Stene
Division of Epidemiology, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
Pediatr Diabetes 11:386-93. 2010....
- The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodiesM Maziarz
Department of Biostatistics, University of Washington, Seattle, WA 98195 7232, USA
Genes Immun 11:406-15. 2010..We hypothesize that the altered T-cell function because of the PTPN22(1858C>T) polymorphism is exclusively associated with GADA-positive T1D at diagnosis...
- Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoireMenno van Lummel
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
J Biol Chem 287:9514-24. 2012..Our findings provide a molecular basis for the association between HLA-DQ transdimers and T1D and set the stage for rational testing of potential diabetogenic peptide epitopes...
- Age-related islet autoantibody incidence in offspring of patients with type 1 diabetesA G Ziegler
Institute of Diabetes Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
Diabetologia 55:1937-43. 2012..Seroconversion to islet autoantibodies precedes type 1 diabetes. This study aimed to identify periods of high seroconversion incidence, which could be targeted for mechanistic and therapeutic studies...
- MICA-A5.1 allele is associated with atypical forms of celiac disease in HLA-DQ2-negative patientsAntonio Lopez-Vazquez
Department of Immunology, Hospital Central de Asturias, C Celestino Villamil, 33 006 Oviedo, Spain
Immunogenetics 53:989-91. 2002..002). No other MICA allele was found to be significantly increased in the groups under study. The presence of MICA-A5.1 in atypical CD DQ2-negative patients may indicate a possible role of this allele in the development of CD...
- Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidenceR Hermann
JDRF Center for Prevention of Type I Diabetes in Finland, University of Turku, Turku, Finland
Diabetes Metab Res Rev 20:322-9. 2004..To develop screening strategies for identification of individuals at increased genetic risk for type 1 diabetes in three populations with variable disease incidence rates and distinct ethnic origin...
- Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 and TNF -308AZdenek Sumnik
Motol University Hospital, Charles University Prague, V Uvalu 84, CZ 150 06, Prague, The Czech Republic
Diabetes Care 29:858-63. 2006....
- Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) studySuzanne K Cordovado
Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F 24, Atlanta, GA 30341, USA
Diabetes 57:518-22. 2008..The availability of phenotypic and genotypic data on GoKinD participants allowed a detailed analysis of the association of these genes with diabetic nephropathy...
- From Type 1, through LADA, to type 2 diabetes: a continuous spectrum?J Lin
Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Ann N Y Acad Sci 1150:99-102. 2008..The preliminary data demonstrated that the susceptible haplotypes of the HLA-DQ gene present a continuous spectrum from typical T1DM, through LADA, to T2DM, which deserves further investigation...
- Association of IL-2RA/CD25 with type 1 diabetes in the Belgian populationFolefac Aminkeng
Diabetes Research Center, Faculty of Medicine and Pharmacy, Brussels Free University Vrije Universiteit Brussel VUB, Brussels, Belgium
Hum Immunol 71:1233-7. 2010..015). In conclusion, IL-2RA/CD25 is associated with type 1 diabetes in the Belgian population, independently of disease phenotype and other biologic markers...
- Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics ConsortiumAna M Wägner
Endocrinology Department, Complejo Hospitalario Universitario Insular Materno Infantil, de Gran Canaria, Spain
Diabetes Metab Res Rev 27:493-8. 2011..The aim of this study was to find predictors of AAIDs in the Type 1 Diabetes Genetics Consortium data set...
- HLA-DQ A1, -DQB1 and -DRB1 gene polymorphism--in Malay type 1 diabetes mellitus patients and their use for risk predictionA G Rohana
Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
Med J Malaysia 66:133-7. 2011..The lower incidence of type 1 DM in the Malay population may be contributed by the genotypic combinations of DR and DQ genes as well as the linkage disequilibria between susceptible and protective alleles...
- Does HLA genotype influence the relative risk of Type 1 diabetes conferred by dietary factors?L C Stene
Diabet Med 19:429-31. 2002
- NEUROD polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech childrenOndrej Cinek
Second Department of Paediatrics, Second Faculty of Medicine, Charles University, V Uvalu 84, Prague 5 CZ 150 06, Czech Republic
Diabetes Res Clin Pract 60:49-56. 2003..No association was observed for the Pro197His mutation which was carried by 5.3% cases and 5.9% controls. Our results confirm that the NEUROD Ala45Thr polymorphism is associated with childhood-onset Type 1 DM...
- Type 1 diabetes in Jewish Ethiopian immigrants in Israel: HLA class II immunogenetics and contribution of new environmentA Zung
Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot, Israel
Hum Immunol 65:1463-8. 2004..621, p = 0.04). We concluded that ongoing exposure of genetically predisposed immigrants from Ethiopia to diabetogenic environmental factors eventually leads to a high incidence of overt diabetes in this ethnic group...
- Variations of the perforin gene in patients with type 1 diabetesElisabetta Orilieri
Interdisciplinary Research Center of Autoimmune Diseases and Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Novara, Italy
Diabetes 57:1078-83. 2008..The aim of this work was to investigate the role of PRF1 variations in type 1 diabetes...
- Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypesKati Lipponen
Immunogenetics Laboratory, University of Turku, Turku, Finland
Diabetes 59:3253-6. 2010..To test this hypothesis we analyzed the role of HLA class I and class II gene polymorphisms in the progression from diabetes-associated autoimmunity to clinical disease...
- HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: a HuGE reviewJ S Dorman
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
Epidemiol Rev 22:218-27. 2000
- Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure?R Hermann
Department of Virology, University of Turku, Finland
Diabetologia 46:420-5. 2003..The aim of this study was to test the possible effect of a changing environment on distribution of genotypes associated with disease susceptibility...
- Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell helpN Chirmule
Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030
Cell Immunol 155:169-82. 1994..Furthermore, these latter reactions occur subsequent to T-B cell contact-dependent interactions at the effector phase, which involve MHC class II molecules on B cells and CD4 molecules on T cells...
- Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2A J K Williams
Diabetes and Metabolism, Clinical Science at North Bristol, University of Bristol Medical School Unit, Southmead Hospital, Bristol, BS10 5NB, UK
Diabetologia 51:1444-8. 2008..To further our understanding of antigen presentation by HLA class II molecules, we have examined the influence of HLA class II genotype on expression of autoantibodies to islet antigen-2 (IA-2A)...
- HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathwayAshutosh Chaudhry
National Institute of Immunology, New Delhi, India
J Immunol 183:2415-24. 2009..Thus, Nef-mediated endocytosis of MHCII provides a novel perspective on the regulation of normal MHCII trafficking...
- Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHCJ F Rowell
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Immunol 155:473-88. 1995....
- Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-BS Nejentsev
Juvenile Diabetes Foundation Center for Type 1 Diabetes Prevention in Finland, Turku
Diabetes 49:2217-21. 2000..Our data indicate that an additional gene associated with type 1 diabetes is located in the 240-kb region near HLA-B. We excluded STR MICA polymorphism as a mutation responsible for diabetes association...
- HIV-1 Nef impairs MHC class II antigen presentation and surface expressionP Stumptner-Cuvelette
Institut National de la Santé et de la Recherche Médicale U520 and Centre National de la Recherche Scientifique UMR144, Institut Curie, 75005 Paris, France
Proc Natl Acad Sci U S A 98:12144-9. 2001..Cooperation between those mechanisms may enable Nef to efficiently inhibit MHC II function...
- HLA-DQ polymorphisms modify the risk of thyroid autoimmunity in children with type 1 diabetes mellitusZ Sumnik
2nd Department of Pediatrics, 2nd Medical School, Charles University, Prague, Czech Republic
J Pediatr Endocrinol Metab 16:851-8. 2003..PATIENTS AND METLHODS: Screening for TAI was performed in 285 children with DM1 by measuring autoantibodies against thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg). HLA-DQA1 and -DQB1 were genotyped using PCR-SSP...
- Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotypeK F Lynch
Department of Clinical Sciences, University Hospital MAS, Lund University, Malmo, Sweden
J Perinatol 28:211-7. 2008..This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both...
- Frequencies of genetic polymorphisms of TLR4 and CD14 and of HLA-DQ genotypes in children with celiac disease, type 1 diabetes mellitus, or bothA Dezsofi
First Department of Pediatrics, Semmelweis University, Hungary
J Pediatr Gastroenterol Nutr 47:283-7. 2008....
- MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birthK Badenhoop
Department of Medicine, Division of Endocrinology, University Hospital Frankfurt, Frankfurt am Main, Germany
Diabetes Obes Metab 11:88-91. 2009..can the degree of an HLA association vary over time periods? and (ii) if a prenatal event like an intrauterine infection - that might cluster in seasons - leads to differences of HLA associations in patients with particular birth months?..
- Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complexM K Viken
Institute of Immunology, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
Genes Immun 10:323-33. 2009..Taken together, our results identify PRSS16 and BTN3A2, two genes thought to play important roles in regulating the immune response, as potentially novel susceptibility genes for T1D...
- HLA genes in Macedonians and the sub-Saharan origin of the GreeksA Arnaiz-Villena
Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, Madrid, Spain
Tissue Antigens 57:118-27. 2001..The time period when these relationships might have occurred was ancient but uncertain and might be related to the displacement of Egyptian-Ethiopian people living in pharaonic Egypt...
- The HLA class I and class II allele frequencies studied at the DNA level in the Svanetian population (Upper Caucasus) and their relationships to Western European populationsP Sanchez-Velasco
Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
Tissue Antigens 58:223-33. 2001..These observations suggest a mixture of alleles in Svans from geographically distinct areas, and probably do not support a common ancestor for these Caucasian inhabitants and people from Northern Spain...
- Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequenciesTatiana S Uinuk-Ool
Laboratory of Human Molecular Genetics, Institute of Cytology and Genetics, Russian Academy of Sciences Siberian Division, Novosibirsk 630090, Russia
Hum Genet 110:209-26. 2002..The divergence time of the two clusters is estimated to be 21,000-24,000 years BP. Three different branches of the native Siberian peoples seem to have contributed founders for the indigenous American ethnic groups...
- HLA profile of three ethnic groups living in the North-Western region of RussiaI Evseeva
Northern State Medical University, Archangel, Russia
Tissue Antigens 59:38-43. 2002..Genetic distances and correspondence analysis show that Pomors have a close relationship with Norwegians and Finns, whereas Nentsy and Saami are more closely related to Oriental populations...
- Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patientsW Thomson
Arthritis Research Campaign Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
Rheumatology (Oxford) 41:1183-9. 2002..To determine the HLA associations with juvenile idiopathic arthritis (JIA) and its subgroups as defined by the International League of Associations for Rheumatology (ILAR) classification criteria...
- MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypesEmilio G De la Concha
Department of Immunology, Hospital Clinico San Carlos, La Paz Hospital, 28040 Madrid, Spain
J Immunol 169:4637-43. 2002....
- HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac DiseaseKati Karell
Department of Tissue Typing, Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
Hum Immunol 64:469-77. 2003..These results underline the primary importance of HLA-DQ alleles in susceptibility to celiac disease, and the extreme rarity of celiac patients carrying neither the DQ2 or DQ8 heterodimers nor one half of the DQ2 heterodimer alone...
- New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European AmericansW Klitz
Children s Hospital Oakland Research Institute, Oakland, CA, USA
Tissue Antigens 62:296-307. 2003..Four DQA1-DQB1 haplotypes, all rare, are reported here for the first time. The haplotype frequency tables are suitable as a reference standard for HLA typing of the DR and DQ loci in European Americans...
- HLA genes in the Chuvashian population from European Russia: admixture of Central European and Mediterranean populationsAntonio Arnaiz-Villena
Department of Microbiology I Immunology, Faculty of Medicine, Universidad Complutense, 28040 Madrid Spain
Hum Biol 75:375-92. 2003..Thus, present-day Chuvash who speak an Altaic-Turkic language are probably more closely related to ancient Mesopotamian-Hittites and northern European populations than to central Asia-Altaic people...
- MHC class II alleles in Mexican patients with rheumatic heart diseaseGuadalupe Hernández-Pacheco
Departments of Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano No 1, Tlalpan 14080, Mexico City, Mexico
Int J Cardiol 92:49-54. 2003..Thus, the aim of the present study was to investigate the role of class II alleles in the genetic susceptibility to RHD in Mexican patients and establish the relationship of these alleles with the pattern of valve damage...
- Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsyChristian Siebold
Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
Proc Natl Acad Sci U S A 101:1999-2004. 2004..In narcolepsy, the volume of the P4 pocket appears central to the susceptibility, suggesting that the presentation of a specific peptide population plays a major role...
- Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populationsT S Uinuk-Ool
Department of Immunogenetics, Max Planck Institute of Biology, Tubingen, Germany
Eur J Immunogenet 31:43-51. 2004....
- Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasisAngélica Olivo-Díaz
Department of Immunogenetics, Instituto de Diagnostico y Referencia Epidemiologicos, Mexico City, Mexico
Hum Immunol 65:255-61. 2004..DR2 (DRB1*1500+DRB1*1600) has also a significant p for protection, suggesting that the sequence common to this group of antigens may anchor parasite peptides which trigger a protective response...
- A sequencing-based typing method for HLA-DQA1 allelesRaja Rajalingam
University of California, Los Angeles, Immunogenetics Center, Department of Pathology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Hum Immunol 65:373-9. 2004..We conclude that the present SBT method is a technically simple and robust procedure to characterize the sequence polymorphisms in exon 2 of DQA1 gene...
- Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patientsSatoshi Murao
Matsuyama Shimin Hospital, Ehime, Japan
Diabetes 53:2684-90. 2004....
- Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell functionKoji Nakanishi
Department of Endocrinology and Metabolism, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
Diabetes 55:1862-8. 2006....
- HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale studyPeter T Donaldson
School of Clinical Medical Sciences Hepatology, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, and Institute of Liver Studies, Kings College Hospital, London, UK
Hepatology 44:667-74. 2006..042, OR=0.65 in the UK patients; and 10% versus 31%, P=.00092, OR=0.25 in the Italian patients). In conclusion, a complex relationship exists between HLA and PBC, and some genetic associations may be population specific...
- A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21David A van Heel
Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, London E1 2AT, UK
Nat Genet 39:827-9. 2007..3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease...
- HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern ChinaE Trachtenberg
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Tissue Antigens 70:455-63. 2007....
- Islet autoantibodies are associated with HLA-DQ genotypes in Han Chinese patients with type 1 diabetes and their relativesJ P Wang
Department of Endocrinology, Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Tissue Antigens 70:369-75. 2007..The findings in the study indicate that some of specific HLA-DQA1/-DQB1 genotypes and haplotypes not only confer susceptibility to T1D but also are associated with the presence of the islet autoantibodies in the Han Chinese population...
- HLA DQ gene dosage and risk and severity of celiac diseaseJoseph A Murray
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 5:1406-12. 2007..The aim of this study was to examine the role of DQA and DQB alleles in determining the risk for and the age of onset and severity of CD in an American population...
- HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlapL R Wedderburn
Rheumatology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
Rheumatology (Oxford) 46:1786-91. 2007..To investigate a large cohort of children with juvenile dermatomyositis (JDM), and those with JDM-scleroderma (JDM-SSc) overlap, using detailed serological analysis, HLA class II genotyping and clinical characterization...
- Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAXGeoffrey Hom
Genentech, South San Francisco, CA 94080, USA
N Engl J Med 358:900-9. 2008..Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci...
- HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium familiesHenry Erlich
Roche Molecular Systems, 1145 Atlantic Ave, Alameda, CA 94501, USA
Diabetes 57:1084-92. 2008..The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes...
- Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screeningJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Coloradoat Denver, Colorado, USA
Diabetes 57:3152-5. 2008..We sought to find an inexpensive, rapid test to identify DR3/4-DQ8 subjects using two single nucleotide polymorphisms (SNPs)...
- Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel diseaseSubra Kugathasan
Department of Pediatrics, Children s Research Institute and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Nat Genet 40:1211-5. 2008..30 x 10(-8) and 6.95 x 10(-8), respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 x 10(-8); OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively...
- HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccineInna G Ovsyannikova
Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
Vaccine 27:3349-58. 2009....
- Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccinationInna G Ovsyannikova
Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
Vaccine 27:3359-66. 2009....
- Differential expression of HLA-DQ alleles in peripheral blood mononuclear cells: alleles associated with susceptibility to and protection from autoimmune type 1 diabetesA C Britten
Department of Medicine, Division of Medical Sciences, University of Birmingham, Birmingham, UK
Int J Immunogenet 36:47-57. 2009..The functional relevance of our findings and their implications for the pathogenesis of autoimmunity remain to be determined...
- Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controlsFrank C Arnett
Division of Rheumatology, Department of Internal Medicine, The University of Texas Health Science Center at Houston UTHSC H, 6431 Fannin Street, MSB 5 270, Houston, TX 77030, USA
Ann Rheum Dis 69:822-7. 2010....
- Genomewide association study of leprosyFu Ren Zhang
Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Science, Jinan, Shandong, China
N Engl J Med 361:2609-18. 2009..Host genetic factors are thought to influence susceptibility to infection as well as disease progression...
- Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathwaysHariklia Eleftherohorinou
Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London W2 1PG, UK
Hum Mol Genet 20:3494-506. 2011....
- HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in KazakhstanA B Kuranov
National Center for Biotechnology, Astana, Kazakhstan
Tissue Antigens 83:106-12. 2014..We observed a possible association between certain HLA alleles and TB that are specific for the Kazakh population. Further studies are needed to confirm our findings using a larger number of patients with drug resistant tuberculosis. ..
- The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in JapaneseJ A Todd
Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford, United Kingdom
Proc Natl Acad Sci U S A 87:1094-8. 1990..The high frequencies of Asp-57-encoding DQB1 alleles in this ethnic group may account for the rarity of type 1 diabetes in Japan...
- HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsetsMauro Galeazzi
Istituto di Reumatologia, Universita di Siena, Siena, Italy
Medicine (Baltimore) 81:169-78. 2002
- Heterozygosity for MICA5.0/MICA5.1 and HLA-DR3-DQ2/DR4-DQ8 are independent genetic risk factors for latent autoimmune diabetes in adultsCarina Torn
Institution of Medicine, Lund University, Lund, Sweden
Hum Immunol 64:902-9. 2003..015-0.96). We concluded that both heterozygosity for MICA5.0/5.1 and HLA-DR3-DQ2/DR4-DQ8 are separate risk factors for LADA, but that heterozygosity for HLA-DR3-DQ2/DR4-DQ8 and DR4-DQ8 alone are most important for type 1 diabetes...
- The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish populationA P Laine
JDRF Centre for Prevention of Type 1 Diabetes, Department of Virology, University of Turku, Turku, Finland
Tissue Antigens 63:72-4. 2004....
- HLA class II genetic association of type 1 diabetes mellitus in Czech childrenO Cinek
2nd Department of Pediatrics, 2nd Medical School of Charles University, Prague Motol, Czech Republic
Pediatr Diabetes 2:98-102. 2001..Since none of the remaining DRB1*04 subtypes was associated with type 1 DM, our study may present another piece of evidence that the DRB1*0401 and DRB1*0404 alleles do not modify type 1 diabetes risk generally in European populations...
- Associations between human leukocyte antigen (HLA) alleles and very high levels of measles antibody following vaccinationInna G Ovsyannikova
Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
Vaccine 22:1914-20. 2004..These data increase our understanding of measles vaccine-induced immune response and will be useful for future mechanistic work on measles virus antigen processing and presentation in seronegative and hyperseropositive individuals...
- The involvement of HLA -DRB1*, DQA1*, DQB1* and complement C4A loci in diagnosing systemic lupus erythematosus among TunisiansKhaled Ayed
Department of Immunology, Faculty of Medicine and Laboratory of Immunology, Charles Nicolle Hospital, Tunis, Tunisia
Ann Saudi Med 24:31-5. 2004..Few data exist on associations of HLA class II and class III alleles of the major histocompatibility complex (MHC) and susceptibility to SLE in Tunisians...
- Analysis of HLA DR, HLA DQ, C4A, FcgammaRIIa, FcgammaRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcgammaRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibilityAndreas Jönsen
Department of Rheumatology, Lund University Hospital, Lund, Sweden
Arthritis Res Ther 6:R557-62. 2004..5-95.4). This study demonstrates that certain combinations of gene variants may increase susceptibility to SLE, suggesting this approach for future studies. It also confirms earlier findings regarding the HLA DR3-DQ2-C4AQ0 haplotype...
- Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetesMaria J Redondo
Department of Endocrinology, University Clinic of Navarra, 31008 Pamplona, Spain
J Clin Endocrinol Metab 91:1705-13. 2006..Human leukocyte antigen (HLA) DQ haplotypes have the strongest genetic association with type 1 diabetes (T1DM) risk...
- In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtypeHector Chinoy
Rheumatic Diseases Centre, Hope Hospital, Salford, UK
Arthritis Res Ther 8:R13. 2006..In conclusion, these findings support the notion that myositis patients with differing myositis serology have different immunogenetic profiles, and that these profiles may define specific myositis subtypes...
- The relation between size at birth and risk of type 1 diabetes is not influenced by adjustment for the insulin gene (-23HphI) polymorphism or HLA-DQ genotypeL C Stene
Division of Epidemiology, Norwegian Institute of Public Health, P O Box 4404, Nydalen, NO 0403, Oslo, Norway
Diabetologia 49:2068-73. 2006....
- HLA related genetic risk for coeliac diseaseMathieu Bourgey
INSERM U535, Universite Paris XI, Villejuif, France
Gut 56:1054-9. 2007..Several studies have shown an elevated prevalence of coeliac disease (CD) in sibs of coeliac patients (risk 8-12%)...
- Ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian multiple sclerosis patientsS V Alves-Leon
Neurology Department, Federal University of Rio de Janeiro State UNIRIO, Rio de Janeiro, Brazil
Acta Neurol Scand 115:306-11. 2007..The present study focused on human leukocyte antigen (HLA) DQB1, DQA1 and DRB1 allelic variation according to ethnicity and analyzed whether susceptibility to multiple sclerosis (MS) depends on population characteristics...
- Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodiesAhmed J Delli
Department of Clinical Sciences, Lund University, Malmo, Sweden
Pediatr Diabetes 11:513-20. 2010..We also determined whether they have different human leukocyte antigen (HLA) genetic markers and islet autoantibodies at diagnosis compared with Swedish patients...
- HLA genotyping in the international Type 1 Diabetes Genetics ConsortiumJosyf C Mychaleckyj
Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
Clin Trials 7:S75-87. 2010....
- HLA class II haplotypes associated with pulmonary interstitial lesions of polymyositis/dermatomyositis in Japanese patientsT Horiki
Department of Rheumatology and Hematology, Tokai University School of Medicine, Kanagawa, Japan
Tissue Antigens 59:25-30. 2002..0% vs 17.7%), and PM without PI (50.0% vs 5.5%). These results suggest that in terms of HLA class II association, Japanese DM and PM, and PM with and without PI, belong to different clinical groups...
- Triplet repeat polymorphism in the transmembrane region of the MICA gene in celiac diseaseL Fernandez
Deparment of Immunology, San Carlos University Hospital, Madrid, Spain
Tissue Antigens 59:219-22. 2002..1 ancestral haplotype in strong linkage disequilibrium with MICA A5.1 allele...
- HLA class II antigens associated with lupus nephritis in Italian SLE patientsMaurizio Marchini
Clinical Immunology, University of Milan, and IRCCS Ospedale Maggiore, Milan, Italy
Hum Immunol 64:462-8. 2003..e., the most severe form of nephritis) is associated with the HLA-DR15 bearing haplotypes...
- Effect of propranolol and IFN-beta on the induction of MHC class II expression and cytokine production by IFN-gamma IN THP-1 human monocytic cellsQ Li
Department of Neurology, Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
Immunopharmacol Immunotoxicol 20:39-61. 1998....
- Gastric parietal cell antibodies are associated with glutamic acid decarboxylase-65 antibodies and the HLA DQA1*0501-DQB1*0301 haplotype in Type 1 diabetes mellitus. Belgian Diabetes RegistryC E De Block
Department of Endocrinology Diabetology, University Hospital Antwerp, Edegem, Belgium
Diabet Med 17:618-22. 2000..To assess the prevalence of thyrogastric autoimmunity in relation to age, sex, beta-cell antibody status and HLA DQ haplotypes in Type 1 diabetes mellitus...
- The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with functionGeorge P Bondinas
Laboratory of Biochemistry and Biophysics, Faculty of Agricultural Technology, Epirus Institute of Technology, GR47100 Arta, Greece
Immunogenetics 59:539-53. 2007....
- Significance of the expression of major histocompatibility complex class II antigen, HLA-DR and -DQ, with recurrence of papillary thyroid cancerYoung Suk Jo
Division of Endocrinology, Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea
Int J Cancer 122:785-90. 2008..59 and 6.07, p = 0.03 and 0.01, respectively). In conclusion, PTC frequently expresses MHC Class II antigen, and the expression of MHC Class II antigen correlated inversely with the risk of recurrence of PTC...
- Mechanisms for HLA-DQ mediated disease protection and susceptibilityWilliam W Kwok; Fiscal Year: 2012..These observations will illuminate important early events in disease progression, providing a new biomarker and suggesting important new avenues for therapy. ..
- HLA-DQ Sequencing Studies in Narcolepsy/Hypocretin DeficiencyEmmanuel J Mignot; Fiscal Year: 2012..the newly developed FLX 454 titanium sequencing technique to generate and analyze high throughput, low cost full HLA DQA1 and DQB1 sequence, and to develop and perfect new statistical analytic tools, such as the Sequence Variant Type ..
- Non-Human Primate Model of Gluten-Sensitive EnteropathyKarol Sestak; Fiscal Year: 2013..abstract_text> ..
- Role of Elastolytic Cathepsins in EmphysemaHarold A Chapman; Fiscal Year: 2010..Identification of biomarkers of cathepsin S activity in COPD patients could :erve as a surrogate for disease progression and an in vivo measure of efficacy during drug trials. ..
- Steven A Porcelli; Fiscal Year: 2015..The information gained will be applied to the design and construction of better vaccines for the prevention of tuberculosis. ..
- MHC Class II Antigen Processing and Immune Recognition of MelanomaKAREN TARASZKA HASTINGS; Fiscal Year: 2011..The long-term goal of these studies is to aid the development of effective immunotherapy for melanoma. ..
- Inhibition of Antigen Presentation in Multiple SclerosisKai W Wucherpfennig; Fiscal Year: 2012..We have discovered small molecules that substantially accelerate peptide binding to MHC class II molecules and will now examine their mechanism of action as well as therapeutic applications in humanized mouse models of MS. ..
- Michael B Brenner; Fiscal Year: 2014..Further, we determine what regulates the process of how cells kill microbes by fusing the vesicles containing the organisms with vesicles that contain factors that can destroy the infections agents. ..
- Generation and Evaluation of Pro-Apoptotic rBCG and Viral Vectors as TB Vaccine CThomas Evans; Fiscal Year: 2012..We will evaluate these regimens in mice and rhesus macaques, models of TB vaccine immunology and efficacy with which we have extensive experience, to expediently select an optimal regimen. ..
- Structural Studies of IgE ReceptorsTheodore S Jardetzky; Fiscal Year: 2010..abstract_text> ..
- Pamela A Wearsch; Fiscal Year: 2014..These studies may also serve as a foundation for the future development of exosome-based diagnostics and therapeutics. ..
- Functional analyses of antiviral CD4+ T cell responsesJ Lindsay Whitton; Fiscal Year: 2013..Might IFN[unreadable] be the "link" by which CD4+ T cells help the development of CD8+ T cell memory? Is the role of IFN[unreadable] the same for specific &non-specific CD4+ helper T cells? ..
- PEPTIDE BASED DELIVERY OF HIV IMMUNOGENLee Riley; Fiscal Year: 1999..While this may be a high risk project, the yield, if shown to work, even as a method to enhance mammalian cell delivery of proteins, should have a significant impact. ..
- Functional Analysis of HCV-B Lymphocyte InteractionsThomas Chambers; Fiscal Year: 2003..abstract_text> ..
- MODULATION OF CIITA BY CANNABINOIDS IN HUMAN MICROGLIADebasish Sinha; Fiscal Year: 2004..Microglia form the first line of defense during infection in the CNS and are involved in various immune diseases including AIDS. ..
- CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATIONHarold Chapman; Fiscal Year: 2007..abstract_text> ..
- MHC CLASS II INDUCTION IN ALLOGRAFT REJECTIONDilip Kittur; Fiscal Year: 1993..This knowledge may be applied in the future to reduce immunogenicity of an allograft to circumvent rejection...
- IMMUNE FUNCTION IN ALLERGIC ENCEPHALOMYELITISRobert Fritz; Fiscal Year: 2003..1+ alpha/beta+ T cells by spectratypic analysis and nucleotide sequence, and 5) to analyze the interaction of NK1.1+ alpha/beta+ T cells with self-reactive T cells. ..
- CIITA REGULATION IN B LYMPHOCYTES AND MULTIPLE MYELOMAKenneth Wright; Fiscal Year: 2003..He also proposes to clone and characterize one of these factors using the yeast one-hybrid system or oligonucleotide screening of phage expression libraries. ..
- IMMUNOBIOLOGY OF TYPE I DIABETESKevin Lafferty; Fiscal Year: 1992....
- CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSISSally Huber; Fiscal Year: 2002..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
- ROLE OF CATHEPSINS S, L AND B IN THE TYPE 1 DIABETESAlexander Rudensky; Fiscal Year: 2003..This work will contribute to our understanding of the role of cathepsins in MHC class II antigen presentation, and provide new targets for downmodulating the immune responses leading to Type 1 diabetes. ..
- SCOTT MATTHEW WILLIAMS; Fiscal Year: 2016..Our working hypothesis is that we will obtain more replicated and hence more real genetic associations using our novel bioinformatics methods that embrace, rather than ignore, prior biological knowledge. ..
- Gluten Sensitivity in the Old Order AmishDaniel McBride; Fiscal Year: 2005..abstract_text> ..
- Jenny T Mao; Fiscal Year: 2015..Findings from the study will provide important insights into the feasibility and mechanistic effects of GSE against lung cancer, help identify SEBM and set the stage for future clinical trials. ..
- Isolation of Genetic Suppressor Elements Against Hepatitis C VirusZhilei Chen; Fiscal Year: 2010..Novel anti-hepatitis C genetic suppressor elements isolated from this research will serve both as hepatitis C drugs, and as keys to open doors to new avenues of research in hepatitis C antiviral development. ..
- Prostate Cancer Prevention by Procyanidins in Grape Seed ExtractChapla Agarwal; Fiscal Year: 2012..Outcomes of our proposed research will provide a mechanism-based agent for the prevention of prostate cancer in humans. ..
- Kequan Zhou; Fiscal Year: 2016....
- Molecular Genetics of Regulated Protein Delivery of the Plasma MembraneCHRIS ALAN KAISER; Fiscal Year: 2010..A final aim of the project is (iv) to understand how ubiquitination is regulated and to identify the cellular components required for recognition of the ubiquitin tag. ..
- IDENTIFICATION OF GENES THAT CONFER LPS SENSITIVITYKeiko Watanabe; Fiscal Year: 1999..The ultimate goal of these studies is to develop novel therapeutic approaches based on increasing the resistance of host cells to the cytotoxic effects of LPS. ..
- MECHANSISM OF CELL GROWTH INHIBITION BY RNASE-LBret Hassel; Fiscal Year: 2001....
- STRESS INDUCED BYSTANDER EFFECT IN CANCER TREATMENTAndrei Gudkov; Fiscal Year: 2004..abstract_text> ..
- Cognitive Effects of Grape Seed Extract-Brain Protein TargetsHelen Kim; Fiscal Year: 2010..The studies will define experimental parameters for future studies with GSE and related dietary supplements to assess mechanisms of action in models of human chronic disease. ..
- TUMOR CELL DEATH INDUCED BY INHIBITION OF REPLICATIONVictor Levenson; Fiscal Year: 2000..The isolated GSEs will also be tested for their effects on cellular response to replication-inhibiting chemotherapeutic drugs, to determine the role of replication-based mechanisms of cytotoxicity in their antitumor effect. ..
- Function-based selection of target genes in tumor cellsIGOR RONINSON; Fiscal Year: 2005..This analysis will provide a database of potential new targets for the development of anticancer drugs. ..
- Functional Activities of HCV Core ProteinRanjit Ray; Fiscal Year: 2005....
- GENETIC ELEMENTS TRANSFORMING MOUSE FIBROBLASTSAndrei Gudkov; Fiscal Year: 2009..The success of the proposed study will indicate development of a powerful target discovery tool that will be applicable for ACTT identification in other types of cancer. ..
- STRUCTURE & IMMUNOBIOLOGY OF IDDM PROTECTIVE MOLECULEWilliam Kwok; Fiscal Year: 2000..These studies address fundamental immune mechanisms, which account for dominant genetic protection, a major gap in our current understanding of the role of HLA genes in IDDM. ..
- GENETIC ELEMENTS SUPPRESSING P53Andrei Gudkov; Fiscal Year: 2000..Using the GSE and two-hybrid approaches, the investigators hope to characterize new factors in the p53 pathway. ..
- Targeted antigens for novel strategies of vaccinationSTEPHEN HEDRICK; Fiscal Year: 2004..More importantly, the experiments will lead to the design of a new generation of vaccines capable of directing the class and thus the effectiveness of immune responses. ..
- Nmb and melanosome function in eye pigment cellsMichael Marks; Fiscal Year: 2005..3. Determine the range of Nmb localization and splice variation in eye tissue of disease-free donors and pigmentary glaucoma patients. ..
- Iron and copper transporter trafficking in healthy and diseased melanocytesMichael Marks; Fiscal Year: 2007..This proposal tests the hypothesis that Hermansky Pudlak Syndrome results from iron and copper dysregulation in the affected cell types. [unreadable] [unreadable] [unreadable]..
- Integrated Instrumentation for ProteomicsHelen Kim; Fiscal Year: 2002....
- MELANOSOME PROTEIN SORTING, FOLDING & ANTIGEN PROCESSINGMichael Marks; Fiscal Year: 2002..The effect of altering the protein sorting and/or retention properties of tyrosinase and gp100 on recognition by specific T cell clones will be determined. ..
- Identification of Measles Class II-Restricted PeptidesINNA OVSYANNIKOVA; Fiscal Year: 2003..The basis from which this proposal will build on is outlined in the background, significance, and preliminary data sections below. ..
- Chicago Childhood Diabetes RegistryRebecca Lipton; Fiscal Year: 2007..Ultimately, this approach will permit a truly population-based molecular epidemiologic study of early-onset diabetes in families from a range of ethnic groups. ..
- DERMATITIS HERPETIFORMIS AND THE MUCOSAL IMMUNE RESPONSERussell Hall; Fiscal Year: 2005..These studies will provide insights into the pathogenesis of DH and isolated GSE, the relationship between the MIR and the skin and factors important in controlling the mucosal immune response in man. ..
- MALDI-TOF to Analyze KIR Association with HIV DiseaseElizabeth Trachtenberg; Fiscal Year: 2006..Data from this study will be critical to future studies examining the functional significance of KIR gene expression in HIV disease. [unreadable] [unreadable]..
- TOLL RECEPTORS IN MACROPHAGE & DENDRITIC CELL ACTIVATIONAnne Stevens; Fiscal Year: 2003....
- Prevention of Photocarcinogenesis by antioxidantSantosh Katiyar; Fiscal Year: 2003..abstract_text> ..
- Maternal Microchimerism in Renal DiseaseAnne Stevens; Fiscal Year: 2006..unreadable] [unreadable]..
- IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSEGregory A Poland; Fiscal Year: 2010..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
- Enhancing Doctor-Patient CommunicationStephanie Lee; Fiscal Year: 2006..The project works towards the overall goal of enhancing communication, improving patient understanding, and facilitating psychosocial adaptation to life-threatening illness. ..
- RADIOIMMUNOTHERAPY OF B CELL LYMPHOMA WITH ANTI CD74M Mattes; Fiscal Year: 2002..This study may lead to the development of more effective radio-conjugates for the therapy of cancer and other diseases. Also, it will provide basic information about the toxic effects of intracellular (really lysosomal) radionuclides. ..
- Tilting the balance in cancer immunotherapy and autoimmunityWei Zen Wei; Fiscal Year: 2010..Establish a vaccination regimen to inhibit spontaneous tumorigenesis and tumor metastasis, and 3. Amplify the immunogenicity of a growing tumor by in situ transfection with TetC DNA. ..
- Prevention of UV-carcinogenesis by antioxidantSantosh Katiyar; Fiscal Year: 2004..abstract_text> ..
- Epidemiology of Celiac Disease: A Population Based StudyJoseph A Murray; Fiscal Year: 2010..This will provide crucial data that will determine the need for early detection by screening and treatment of silent celiac disease, which may affect 1% of Americans. ..
- Proanthocyanidins: Novel Skin Cancer Preventive AgentSantosh Katiyar; Fiscal Year: 2006..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
- HLA-DP SEQUENCE POLYMORPHISM AND DISEASE PREDISPOSITIONHenry Erlich; Fiscal Year: 2003..This method will be applied to HPV-infected cervical samples and an in vitro system with GAD peptide stimulation to study the HLA associations with cervical cancer and type 1 diabetes. ..
- International Congress of the Immunology of Diabetes SocGeorge Eisenbarth; Fiscal Year: 2002..Travel grants for young investigators will be chosen by numerical rating of submitted abstracts and additional travel funding will be applied to plenary lectures chosen by the international organizing committee. ..
- Immunomodulation by MHC Class II PeptidesBarbara Murphy; Fiscal Year: 2005..These studies will help elucidate the potential role of MHC class II peptides in the prevention of transplant rejection and the induction of tolerance. ..
- Oxidative mutagenesis:Iron, Ascorbic Acid and GenesChristopher Bowlus; Fiscal Year: 2002..They will use a mouse model of HH that is prone to hepatocellular formation. ..
- Disease concurrence in type 1 diabetesWilliam Klitz; Fiscal Year: 2005..Immune, endocrine and prenatal events will supply the functional background for interpreting age of onset, order of disease onset, gender and the relationship of infectious disease effects relative to T1D concurrence. ..
- Ovarian Cancer Detection Using H-NMR_Based MetabonomicsKunle Odunsi; Fiscal Year: 2006..The proposed studies may lead to the identification of novel biomarkers for early detection of EOC, that will be evaluated further in prospective studies for early detection of EOC in general and high-risk populations. ..
- DQB1*0602 RELATIVES--MECHANISMS FOR DIABETES PROTECTIONCarla Greenbaum; Fiscal Year: 2001..This proposal includes collaborative agreements between the University of Washington and the Universities of Florida (Gainesville), South Florida (Tampa), and Colorado. ..
- Statistical Genetic Methods for Cancer Gene StudiesSusan Slager; Fiscal Year: 2006..abstract_text> ..
- Identification of Early Markers for Ovarian CancerAnna Lokshin; Fiscal Year: 2006..By the end of the proposed project, we expect to construct a test based on a panel of ovarian cancer-specific antigens that has the most promising characteristics to identify women with ovarian cancer. ..
- Prevention of skin cancer by green tea polyphenolsSantosh Katiyar; Fiscal Year: 2009..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
- The genetic basis of type 1 diabetes autoimmunity in African AmericansJanelle Noble; Fiscal Year: 2008..abstract_text> ..
- A HLA Mouse Model for Gluten Sensitivity and EnteropathyJoseph Murray; Fiscal Year: 2009..abstract_text> ..
- Development of Rotational Fluctuation Spectroscopy for Biological ApplicationsB Barisas; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Inflammation and Ovarian CancerClareann Bunker; Fiscal Year: 2008..In particular, NSAID use may prove to be a potentially important chemopreventative for this often-fatal disease. ..
- Tacrolimus and Plasmapheresis in Treatment-Resistant FSGSTej Mattoo; Fiscal Year: 2007..The proposed study will offer new treatment options in such patients and save many from the pain and the distress of undergoing dialysis and renal transplantation. [unreadable] [unreadable] [unreadable]..