HLA DQA1

Summary

Gene Symbol: HLA DQA1
Description: major histocompatibility complex, class II, DQ alpha 1
Alias: CELIAC1, DQ-A1, HLA-DQA, HLA class II histocompatibility antigen, DQ alpha 1 chain, DC-1 alpha chain, DC-alpha, HLA-DCA, MHC HLA-DQ alpha, MHC class II DQA1, MHC class II HLA-DQ-alpha-1
Species: human

Top Publications

  1. ncbi HLA-DQA1*0501 is associated with diffuse systemic sclerosis in Caucasian men
    N C Lambert
    Immunogenetics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Arthritis Rheum 43:2005-10. 2000
  2. ncbi Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women
    P C Maciag
    Department of Genetics, Federal University of Parana, Curitiba, Brazil
    Cancer Epidemiol Biomarkers Prev 9:1183-91. 2000
  3. pmc Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility
    Matthew R Lincoln
    University Department of Clinical Neurology, Third Floor, West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7542-7. 2009
  4. pmc Common variants on chromosome 6p22.1 are associated with schizophrenia
    Jianxin Shi
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
    Nature 460:753-7. 2009
  5. doi IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population
    Folefac Aminkeng
    Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium
    Hum Immunol 70:706-10. 2009
  6. doi HLA-Class II in Latin American patients with type 1 diabetes
    Adriana Rojas-Villarraga
    Center for Autoimmune Diseases Research, Universidad del Rosario, Bogota, Colombia
    Autoimmun Rev 9:666-73. 2010
  7. pmc Leprosy and the adaptation of human toll-like receptor 1
    Sunny H Wong
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 6:e1000979. 2010
  8. pmc Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 40:1399-401. 2008
  9. doi Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection
    Rae Anne Hardie
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    AIDS 22:807-16. 2008
  10. doi Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
    Sabina Resic-Lindehammer
    Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC Lund University, Ent 72 Bldg 91 Floor 10, 205 02 Malmo, Sweden
    Acta Diabetol 45:231-5. 2008

Research Grants

  1. Mechanisms for HLA-DQ mediated disease protection and susceptibility
    William W Kwok; Fiscal Year: 2012
  2. HLA-DQ Sequencing Studies in Narcolepsy/Hypocretin Deficiency
    Emmanuel J Mignot; Fiscal Year: 2012
  3. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2013
  4. Role of Elastolytic Cathepsins in Emphysema
    Harold A Chapman; Fiscal Year: 2010
  5. Steven A Porcelli; Fiscal Year: 2015
  6. MHC Class II Antigen Processing and Immune Recognition of Melanoma
    KAREN TARASZKA HASTINGS; Fiscal Year: 2011
  7. Inhibition of Antigen Presentation in Multiple Sclerosis
    Kai W Wucherpfennig; Fiscal Year: 2012
  8. Michael B Brenner; Fiscal Year: 2014
  9. Generation and Evaluation of Pro-Apoptotic rBCG and Viral Vectors as TB Vaccine C
    Thomas Evans; Fiscal Year: 2012
  10. Structural Studies of IgE Receptors
    Theodore S Jardetzky; Fiscal Year: 2010

Detail Information

Publications253 found, 100 shown here

  1. ncbi HLA-DQA1*0501 is associated with diffuse systemic sclerosis in Caucasian men
    N C Lambert
    Immunogenetics Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Arthritis Rheum 43:2005-10. 2000
    ..In the current study, we investigated HLA class II alleles in men with SSc. We also investigated the hypothesis that HLA compatibility of the mother could be a risk factor for SSc in men...
  2. ncbi Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women
    P C Maciag
    Department of Genetics, Federal University of Parana, Curitiba, Brazil
    Cancer Epidemiol Biomarkers Prev 9:1183-91. 2000
    ..48; 95% CI, 1.06-5.80). We suggest that HLA class II polymorphisms are involved in genetic susceptibility to cervical cancer and HPV infection in a Brazilian population from an area with a high incidence of this neoplasia...
  3. pmc Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility
    Matthew R Lincoln
    University Department of Clinical Neurology, Third Floor, West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7542-7. 2009
    ..MHC disease associations may be more generally haplotypic or diplotypic...
  4. pmc Common variants on chromosome 6p22.1 are associated with schizophrenia
    Jianxin Shi
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
    Nature 460:753-7. 2009
    ..These results demonstrate that common schizophrenia susceptibility alleles can be detected. The characterization of these signals will suggest important directions for research on susceptibility mechanisms...
  5. doi IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population
    Folefac Aminkeng
    Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium
    Hum Immunol 70:706-10. 2009
    ..76, p = 0.19) and no interaction with HLA-DQ-linked risk. Furthermore, no genotype-phenotype correlation was observed. In conclusion, IFIH1 has no important role in T1D risk assessment in a registry-based Belgian population...
  6. doi HLA-Class II in Latin American patients with type 1 diabetes
    Adriana Rojas-Villarraga
    Center for Autoimmune Diseases Research, Universidad del Rosario, Bogota, Colombia
    Autoimmun Rev 9:666-73. 2010
    ..To identify and estimate the common effect size of HLA-Class II contributing to susceptibility on T1D in Latin America (LA) through a meta-analysis...
  7. pmc Leprosy and the adaptation of human toll-like receptor 1
    Sunny H Wong
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 6:e1000979. 2010
    ..These observations provide insight into the long standing host-pathogen relationship between human and mycobacteria and highlight the key role of the TLR pathway in infectious diseases...
  8. pmc Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 40:1399-401. 2008
    ..7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8))...
  9. doi Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection
    Rae Anne Hardie
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    AIDS 22:807-16. 2008
    ..To determine the association of DQ antigens with resistance and susceptibility to HIV-1...
  10. doi Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
    Sabina Resic-Lindehammer
    Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC Lund University, Ent 72 Bldg 91 Floor 10, 205 02 Malmo, Sweden
    Acta Diabetol 45:231-5. 2008
    ..The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to ..
  11. ncbi Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls
    Liene Nikitina-Zake
    Immunogenetics, Molecular Medicine, L8 00, Karolinska Hospital, Karolinska Institutet, 17176 Stockholm, Sweden
    Ann N Y Acad Sci 1037:161-9. 2004
    ..3), was higher. The maximum risk was when KIR2DL2, MICA5, and DR3/DR4 were in combination. In conclusion, our results suggest that a balance between innate and acquired immunity is important, and an imbalance coud lead to T1DM...
  12. pmc Diabetes-specific HLA-DR-restricted proinflammatory T-cell response to wheat polypeptides in tissue transglutaminase antibody-negative patients with type 1 diabetes
    Majid Mojibian
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada
    Diabetes 58:1789-96. 2009
    ..However, questions arise regarding the frequency of abnormal immune responses to wheat and their nature, and it remains unclear whether such responses are diabetes specific...
  13. pmc HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Diabetes 59:2972-9. 2010
    ..We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study...
  14. doi Polymorphisms of CXCR3-binding chemokines in type 1 diabetes
    Patrick Bruck
    Department of Internal Medicine IV, Division of Haematology and Oncology, University Hospital Giessen and Marburg, Germany
    Hum Immunol 70:552-5. 2009
    ..Although we did not find an association of the CXCL9 and CXCL10 polymorphisms with type 1 diabetes in the German population, we cannot discard their role in other populations or other autoimmune diseases...
  15. ncbi The rare HLA-DQA1*03-DQB1*02 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjects
    Jan E van Autreve
    Diabetes Research Center, Molecular Diagnosis, Vrije Universteit Brussel, B 1070 Brussels, Belgium
    Hum Immunol 65:729-36. 2004
    ..These results are compatible with an effect of cis-encoded heterodimers or with previously suggested interactions of X-linked genetic factors with (DR3-)DQB1*02 haplotypes...
  16. doi HLA-DR-DQ haplotypes and type 1 diabetes in Macedonia
    Jorma Ilonen
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Hum Immunol 70:461-3. 2009
    ....
  17. doi An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphisms
    Lars C Stene
    Division of Epidemiology, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Pediatr Diabetes 11:386-93. 2010
    ....
  18. pmc The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies
    M Maziarz
    Department of Biostatistics, University of Washington, Seattle, WA 98195 7232, USA
    Genes Immun 11:406-15. 2010
    ..We hypothesize that the altered T-cell function because of the PTPN22(1858C>T) polymorphism is exclusively associated with GADA-positive T1D at diagnosis...
  19. pmc Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Biol Chem 287:9514-24. 2012
    ..Our findings provide a molecular basis for the association between HLA-DQ transdimers and T1D and set the stage for rational testing of potential diabetogenic peptide epitopes...
  20. doi Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes
    A G Ziegler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Diabetologia 55:1937-43. 2012
    ..Seroconversion to islet autoantibodies precedes type 1 diabetes. This study aimed to identify periods of high seroconversion incidence, which could be targeted for mechanistic and therapeutic studies...
  21. ncbi MICA-A5.1 allele is associated with atypical forms of celiac disease in HLA-DQ2-negative patients
    Antonio Lopez-Vazquez
    Department of Immunology, Hospital Central de Asturias, C Celestino Villamil, 33 006 Oviedo, Spain
    Immunogenetics 53:989-91. 2002
    ..002). No other MICA allele was found to be significantly increased in the groups under study. The presence of MICA-A5.1 in atypical CD DQ2-negative patients may indicate a possible role of this allele in the development of CD...
  22. ncbi Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence
    R Hermann
    JDRF Center for Prevention of Type I Diabetes in Finland, University of Turku, Turku, Finland
    Diabetes Metab Res Rev 20:322-9. 2004
    ..To develop screening strategies for identification of individuals at increased genetic risk for type 1 diabetes in three populations with variable disease incidence rates and distinct ethnic origin...
  23. ncbi Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 and TNF -308A
    Zdenek Sumnik
    Motol University Hospital, Charles University Prague, V Uvalu 84, CZ 150 06, Prague, The Czech Republic
    Diabetes Care 29:858-63. 2006
    ....
  24. pmc Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study
    Suzanne K Cordovado
    Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F 24, Atlanta, GA 30341, USA
    Diabetes 57:518-22. 2008
    ..The availability of phenotypic and genotypic data on GoKinD participants allowed a detailed analysis of the association of these genes with diabetic nephropathy...
  25. doi From Type 1, through LADA, to type 2 diabetes: a continuous spectrum?
    J Lin
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Ann N Y Acad Sci 1150:99-102. 2008
    ..The preliminary data demonstrated that the susceptible haplotypes of the HLA-DQ gene present a continuous spectrum from typical T1DM, through LADA, to T2DM, which deserves further investigation...
  26. doi Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population
    Folefac Aminkeng
    Diabetes Research Center, Faculty of Medicine and Pharmacy, Brussels Free University Vrije Universiteit Brussel VUB, Brussels, Belgium
    Hum Immunol 71:1233-7. 2010
    ..015). In conclusion, IL-2RA/CD25 is associated with type 1 diabetes in the Belgian population, independently of disease phenotype and other biologic markers...
  27. pmc Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Ana M Wägner
    Endocrinology Department, Complejo Hospitalario Universitario Insular Materno Infantil, de Gran Canaria, Spain
    Diabetes Metab Res Rev 27:493-8. 2011
    ..The aim of this study was to find predictors of AAIDs in the Type 1 Diabetes Genetics Consortium data set...
  28. ncbi HLA-DQ A1, -DQB1 and -DRB1 gene polymorphism--in Malay type 1 diabetes mellitus patients and their use for risk prediction
    A G Rohana
    Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
    Med J Malaysia 66:133-7. 2011
    ..The lower incidence of type 1 DM in the Malay population may be contributed by the genotypic combinations of DR and DQ genes as well as the linkage disequilibria between susceptible and protective alleles...
  29. ncbi Does HLA genotype influence the relative risk of Type 1 diabetes conferred by dietary factors?
    L C Stene
    Diabet Med 19:429-31. 2002
  30. ncbi NEUROD polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech children
    Ondrej Cinek
    Second Department of Paediatrics, Second Faculty of Medicine, Charles University, V Uvalu 84, Prague 5 CZ 150 06, Czech Republic
    Diabetes Res Clin Pract 60:49-56. 2003
    ..No association was observed for the Pro197His mutation which was carried by 5.3% cases and 5.9% controls. Our results confirm that the NEUROD Ala45Thr polymorphism is associated with childhood-onset Type 1 DM...
  31. ncbi Type 1 diabetes in Jewish Ethiopian immigrants in Israel: HLA class II immunogenetics and contribution of new environment
    A Zung
    Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot, Israel
    Hum Immunol 65:1463-8. 2004
    ..621, p = 0.04). We concluded that ongoing exposure of genetically predisposed immigrants from Ethiopia to diabetogenic environmental factors eventually leads to a high incidence of overt diabetes in this ethnic group...
  32. doi Variations of the perforin gene in patients with type 1 diabetes
    Elisabetta Orilieri
    Interdisciplinary Research Center of Autoimmune Diseases and Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Novara, Italy
    Diabetes 57:1078-83. 2008
    ..The aim of this work was to investigate the role of PRF1 variations in type 1 diabetes...
  33. pmc Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes
    Kati Lipponen
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Diabetes 59:3253-6. 2010
    ..To test this hypothesis we analyzed the role of HLA class I and class II gene polymorphisms in the progression from diabetes-associated autoimmunity to clinical disease...
  34. ncbi HLA-DQ locus of the human leukocyte antigen complex and type 1 diabetes mellitus: a HuGE review
    J S Dorman
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Epidemiol Rev 22:218-27. 2000
  35. ncbi Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure?
    R Hermann
    Department of Virology, University of Turku, Finland
    Diabetologia 46:420-5. 2003
    ..The aim of this study was to test the possible effect of a changing environment on distribution of genotypes associated with disease susceptibility...
  36. ncbi Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help
    N Chirmule
    Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030
    Cell Immunol 155:169-82. 1994
    ..Furthermore, these latter reactions occur subsequent to T-B cell contact-dependent interactions at the effector phase, which involve MHC class II molecules on B cells and CD4 molecules on T cells...
  37. doi Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2
    A J K Williams
    Diabetes and Metabolism, Clinical Science at North Bristol, University of Bristol Medical School Unit, Southmead Hospital, Bristol, BS10 5NB, UK
    Diabetologia 51:1444-8. 2008
    ..To further our understanding of antigen presentation by HLA class II molecules, we have examined the influence of HLA class II genotype on expression of autoantibodies to islet antigen-2 (IA-2A)...
  38. doi HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway
    Ashutosh Chaudhry
    National Institute of Immunology, New Delhi, India
    J Immunol 183:2415-24. 2009
    ..Thus, Nef-mediated endocytosis of MHCII provides a novel perspective on the regulation of normal MHCII trafficking...
  39. ncbi Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC
    J F Rowell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 155:473-88. 1995
    ....
  40. ncbi Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B
    S Nejentsev
    Juvenile Diabetes Foundation Center for Type 1 Diabetes Prevention in Finland, Turku
    Diabetes 49:2217-21. 2000
    ..Our data indicate that an additional gene associated with type 1 diabetes is located in the 240-kb region near HLA-B. We excluded STR MICA polymorphism as a mutation responsible for diabetes association...
  41. pmc HIV-1 Nef impairs MHC class II antigen presentation and surface expression
    P Stumptner-Cuvelette
    Institut National de la Santé et de la Recherche Médicale U520 and Centre National de la Recherche Scientifique UMR144, Institut Curie, 75005 Paris, France
    Proc Natl Acad Sci U S A 98:12144-9. 2001
    ..Cooperation between those mechanisms may enable Nef to efficiently inhibit MHC II function...
  42. ncbi HLA-DQ polymorphisms modify the risk of thyroid autoimmunity in children with type 1 diabetes mellitus
    Z Sumnik
    2nd Department of Pediatrics, 2nd Medical School, Charles University, Prague, Czech Republic
    J Pediatr Endocrinol Metab 16:851-8. 2003
    ..PATIENTS AND METLHODS: Screening for TAI was performed in 285 children with DM1 by measuring autoantibodies against thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg). HLA-DQA1 and -DQB1 were genotyped using PCR-SSP...
  43. doi Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype
    K F Lynch
    Department of Clinical Sciences, University Hospital MAS, Lund University, Malmo, Sweden
    J Perinatol 28:211-7. 2008
    ..This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both...
  44. doi Frequencies of genetic polymorphisms of TLR4 and CD14 and of HLA-DQ genotypes in children with celiac disease, type 1 diabetes mellitus, or both
    A Dezsofi
    First Department of Pediatrics, Semmelweis University, Hungary
    J Pediatr Gastroenterol Nutr 47:283-7. 2008
    ....
  45. pmc MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth
    K Badenhoop
    Department of Medicine, Division of Endocrinology, University Hospital Frankfurt, Frankfurt am Main, Germany
    Diabetes Obes Metab 11:88-91. 2009
    ..can the degree of an HLA association vary over time periods? and (ii) if a prenatal event like an intrauterine infection - that might cluster in seasons - leads to differences of HLA associations in patients with particular birth months?..
  46. doi Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex
    M K Viken
    Institute of Immunology, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
    Genes Immun 10:323-33. 2009
    ..Taken together, our results identify PRSS16 and BTN3A2, two genes thought to play important roles in regulating the immune response, as potentially novel susceptibility genes for T1D...
  47. ncbi HLA genes in Macedonians and the sub-Saharan origin of the Greeks
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 57:118-27. 2001
    ..The time period when these relationships might have occurred was ancient but uncertain and might be related to the displacement of Egyptian-Ethiopian people living in pharaonic Egypt...
  48. ncbi The HLA class I and class II allele frequencies studied at the DNA level in the Svanetian population (Upper Caucasus) and their relationships to Western European populations
    P Sanchez-Velasco
    Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Instituto Nacional de la Salud, Santander, Spain
    Tissue Antigens 58:223-33. 2001
    ..These observations suggest a mixture of alleles in Svans from geographically distinct areas, and probably do not support a common ancestor for these Caucasian inhabitants and people from Northern Spain...
  49. ncbi Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies
    Tatiana S Uinuk-Ool
    Laboratory of Human Molecular Genetics, Institute of Cytology and Genetics, Russian Academy of Sciences Siberian Division, Novosibirsk 630090, Russia
    Hum Genet 110:209-26. 2002
    ..The divergence time of the two clusters is estimated to be 21,000-24,000 years BP. Three different branches of the native Siberian peoples seem to have contributed founders for the indigenous American ethnic groups...
  50. ncbi HLA profile of three ethnic groups living in the North-Western region of Russia
    I Evseeva
    Northern State Medical University, Archangel, Russia
    Tissue Antigens 59:38-43. 2002
    ..Genetic distances and correspondence analysis show that Pomors have a close relationship with Norwegians and Finns, whereas Nentsy and Saami are more closely related to Oriental populations...
  51. ncbi Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients
    W Thomson
    Arthritis Research Campaign Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 41:1183-9. 2002
    ..To determine the HLA associations with juvenile idiopathic arthritis (JIA) and its subgroups as defined by the International League of Associations for Rheumatology (ILAR) classification criteria...
  52. ncbi MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypes
    Emilio G De la Concha
    Department of Immunology, Hospital Clinico San Carlos, La Paz Hospital, 28040 Madrid, Spain
    J Immunol 169:4637-43. 2002
    ....
  53. ncbi HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease
    Kati Karell
    Department of Tissue Typing, Finnish Red Cross Blood Transfusion Service, Helsinki, Finland
    Hum Immunol 64:469-77. 2003
    ..These results underline the primary importance of HLA-DQ alleles in susceptibility to celiac disease, and the extreme rarity of celiac patients carrying neither the DQ2 or DQ8 heterodimers nor one half of the DQ2 heterodimer alone...
  54. ncbi New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans
    W Klitz
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Tissue Antigens 62:296-307. 2003
    ..Four DQA1-DQB1 haplotypes, all rare, are reported here for the first time. The haplotype frequency tables are suitable as a reference standard for HLA typing of the DR and DQ loci in European Americans...
  55. ncbi HLA genes in the Chuvashian population from European Russia: admixture of Central European and Mediterranean populations
    Antonio Arnaiz-Villena
    Department of Microbiology I Immunology, Faculty of Medicine, Universidad Complutense, 28040 Madrid Spain
    Hum Biol 75:375-92. 2003
    ..Thus, present-day Chuvash who speak an Altaic-Turkic language are probably more closely related to ancient Mesopotamian-Hittites and northern European populations than to central Asia-Altaic people...
  56. ncbi MHC class II alleles in Mexican patients with rheumatic heart disease
    Guadalupe Hernández-Pacheco
    Departments of Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano No 1, Tlalpan 14080, Mexico City, Mexico
    Int J Cardiol 92:49-54. 2003
    ..Thus, the aim of the present study was to investigate the role of class II alleles in the genetic susceptibility to RHD in Mexican patients and establish the relationship of these alleles with the pattern of valve damage...
  57. pmc Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy
    Christian Siebold
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 101:1999-2004. 2004
    ..In narcolepsy, the volume of the P4 pocket appears central to the susceptibility, suggesting that the presentation of a specific peptide population plays a major role...
  58. ncbi Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations
    T S Uinuk-Ool
    Department of Immunogenetics, Max Planck Institute of Biology, Tubingen, Germany
    Eur J Immunogenet 31:43-51. 2004
    ....
  59. ncbi Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis
    Angélica Olivo-Díaz
    Department of Immunogenetics, Instituto de Diagnostico y Referencia Epidemiologicos, Mexico City, Mexico
    Hum Immunol 65:255-61. 2004
    ..DR2 (DRB1*1500+DRB1*1600) has also a significant p for protection, suggesting that the sequence common to this group of antigens may anchor parasite peptides which trigger a protective response...
  60. ncbi A sequencing-based typing method for HLA-DQA1 alleles
    Raja Rajalingam
    University of California, Los Angeles, Immunogenetics Center, Department of Pathology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Hum Immunol 65:373-9. 2004
    ..We conclude that the present SBT method is a technically simple and robust procedure to characterize the sequence polymorphisms in exon 2 of DQA1 gene...
  61. ncbi Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patients
    Satoshi Murao
    Matsuyama Shimin Hospital, Ehime, Japan
    Diabetes 53:2684-90. 2004
    ....
  62. ncbi Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function
    Koji Nakanishi
    Department of Endocrinology and Metabolism, Toranomon Hospital, 2 2 2 Toranomon, Minato ku, Tokyo 105 8470, Japan
    Diabetes 55:1862-8. 2006
    ....
  63. ncbi HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study
    Peter T Donaldson
    School of Clinical Medical Sciences Hepatology, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, and Institute of Liver Studies, Kings College Hospital, London, UK
    Hepatology 44:667-74. 2006
    ..042, OR=0.65 in the UK patients; and 10% versus 31%, P=.00092, OR=0.25 in the Italian patients). In conclusion, a complex relationship exists between HLA and PBC, and some genetic associations may be population specific...
  64. pmc A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    David A van Heel
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Queen Mary University of London, London E1 2AT, UK
    Nat Genet 39:827-9. 2007
    ..3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease...
  65. ncbi HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China
    E Trachtenberg
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Tissue Antigens 70:455-63. 2007
    ....
  66. ncbi Islet autoantibodies are associated with HLA-DQ genotypes in Han Chinese patients with type 1 diabetes and their relatives
    J P Wang
    Department of Endocrinology, Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Tissue Antigens 70:369-75. 2007
    ..The findings in the study indicate that some of specific HLA-DQA1/-DQB1 genotypes and haplotypes not only confer susceptibility to T1D but also are associated with the presence of the islet autoantibodies in the Han Chinese population...
  67. pmc HLA DQ gene dosage and risk and severity of celiac disease
    Joseph A Murray
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 5:1406-12. 2007
    ..The aim of this study was to examine the role of DQA and DQB alleles in determining the risk for and the age of onset and severity of CD in an American population...
  68. ncbi HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap
    L R Wedderburn
    Rheumatology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Rheumatology (Oxford) 46:1786-91. 2007
    ..To investigate a large cohort of children with juvenile dermatomyositis (JDM), and those with JDM-scleroderma (JDM-SSc) overlap, using detailed serological analysis, HLA class II genotyping and clinical characterization...
  69. doi Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
    Geoffrey Hom
    Genentech, South San Francisco, CA 94080, USA
    N Engl J Med 358:900-9. 2008
    ..Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci...
  70. pmc HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families
    Henry Erlich
    Roche Molecular Systems, 1145 Atlantic Ave, Alameda, CA 94501, USA
    Diabetes 57:1084-92. 2008
    ..The aim of this study is to estimate the risk conferred by specific DR-DQ haplotypes and genotypes...
  71. pmc Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screening
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Coloradoat Denver, Colorado, USA
    Diabetes 57:3152-5. 2008
    ..We sought to find an inexpensive, rapid test to identify DR3/4-DQ8 subjects using two single nucleotide polymorphisms (SNPs)...
  72. pmc Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
    Subra Kugathasan
    Department of Pediatrics, Children s Research Institute and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nat Genet 40:1211-5. 2008
    ..30 x 10(-8) and 6.95 x 10(-8), respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 x 10(-8); OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively...
  73. pmc HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3349-58. 2009
    ....
  74. pmc Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3359-66. 2009
    ....
  75. doi Differential expression of HLA-DQ alleles in peripheral blood mononuclear cells: alleles associated with susceptibility to and protection from autoimmune type 1 diabetes
    A C Britten
    Department of Medicine, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Int J Immunogenet 36:47-57. 2009
    ..The functional relevance of our findings and their implications for the pathogenesis of autoimmunity remain to be determined...
  76. pmc Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls
    Frank C Arnett
    Division of Rheumatology, Department of Internal Medicine, The University of Texas Health Science Center at Houston UTHSC H, 6431 Fannin Street, MSB 5 270, Houston, TX 77030, USA
    Ann Rheum Dis 69:822-7. 2010
    ....
  77. doi Genomewide association study of leprosy
    Fu Ren Zhang
    Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Science, Jinan, Shandong, China
    N Engl J Med 361:2609-18. 2009
    ..Host genetic factors are thought to influence susceptibility to infection as well as disease progression...
  78. doi Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways
    Hariklia Eleftherohorinou
    Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London W2 1PG, UK
    Hum Mol Genet 20:3494-506. 2011
    ....
  79. doi HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in Kazakhstan
    A B Kuranov
    National Center for Biotechnology, Astana, Kazakhstan
    Tissue Antigens 83:106-12. 2014
    ..We observed a possible association between certain HLA alleles and TB that are specific for the Kazakh population. Further studies are needed to confirm our findings using a larger number of patients with drug resistant tuberculosis. ..
  80. pmc The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese
    J A Todd
    Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Proc Natl Acad Sci U S A 87:1094-8. 1990
    ..The high frequencies of Asp-57-encoding DQB1 alleles in this ethnic group may account for the rarity of type 1 diabetes in Japan...
  81. ncbi HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets
    Mauro Galeazzi
    Istituto di Reumatologia, Universita di Siena, Siena, Italy
    Medicine (Baltimore) 81:169-78. 2002
  82. ncbi Heterozygosity for MICA5.0/MICA5.1 and HLA-DR3-DQ2/DR4-DQ8 are independent genetic risk factors for latent autoimmune diabetes in adults
    Carina Torn
    Institution of Medicine, Lund University, Lund, Sweden
    Hum Immunol 64:902-9. 2003
    ..015-0.96). We concluded that both heterozygosity for MICA5.0/5.1 and HLA-DR3-DQ2/DR4-DQ8 are separate risk factors for LADA, but that heterozygosity for HLA-DR3-DQ2/DR4-DQ8 and DR4-DQ8 alone are most important for type 1 diabetes...
  83. ncbi The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population
    A P Laine
    JDRF Centre for Prevention of Type 1 Diabetes, Department of Virology, University of Turku, Turku, Finland
    Tissue Antigens 63:72-4. 2004
    ....
  84. ncbi HLA class II genetic association of type 1 diabetes mellitus in Czech children
    O Cinek
    2nd Department of Pediatrics, 2nd Medical School of Charles University, Prague Motol, Czech Republic
    Pediatr Diabetes 2:98-102. 2001
    ..Since none of the remaining DRB1*04 subtypes was associated with type 1 DM, our study may present another piece of evidence that the DRB1*0401 and DRB1*0404 alleles do not modify type 1 diabetes risk generally in European populations...
  85. ncbi Associations between human leukocyte antigen (HLA) alleles and very high levels of measles antibody following vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 22:1914-20. 2004
    ..These data increase our understanding of measles vaccine-induced immune response and will be useful for future mechanistic work on measles virus antigen processing and presentation in seronegative and hyperseropositive individuals...
  86. ncbi The involvement of HLA -DRB1*, DQA1*, DQB1* and complement C4A loci in diagnosing systemic lupus erythematosus among Tunisians
    Khaled Ayed
    Department of Immunology, Faculty of Medicine and Laboratory of Immunology, Charles Nicolle Hospital, Tunis, Tunisia
    Ann Saudi Med 24:31-5. 2004
    ..Few data exist on associations of HLA class II and class III alleles of the major histocompatibility complex (MHC) and susceptibility to SLE in Tunisians...
  87. pmc Analysis of HLA DR, HLA DQ, C4A, FcgammaRIIa, FcgammaRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcgammaRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility
    Andreas Jönsen
    Department of Rheumatology, Lund University Hospital, Lund, Sweden
    Arthritis Res Ther 6:R557-62. 2004
    ..5-95.4). This study demonstrates that certain combinations of gene variants may increase susceptibility to SLE, suggesting this approach for future studies. It also confirms earlier findings regarding the HLA DR3-DQ2-C4AQ0 haplotype...
  88. ncbi Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes
    Maria J Redondo
    Department of Endocrinology, University Clinic of Navarra, 31008 Pamplona, Spain
    J Clin Endocrinol Metab 91:1705-13. 2006
    ..Human leukocyte antigen (HLA) DQ haplotypes have the strongest genetic association with type 1 diabetes (T1DM) risk...
  89. pmc In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype
    Hector Chinoy
    Rheumatic Diseases Centre, Hope Hospital, Salford, UK
    Arthritis Res Ther 8:R13. 2006
    ..In conclusion, these findings support the notion that myositis patients with differing myositis serology have different immunogenetic profiles, and that these profiles may define specific myositis subtypes...
  90. ncbi The relation between size at birth and risk of type 1 diabetes is not influenced by adjustment for the insulin gene (-23HphI) polymorphism or HLA-DQ genotype
    L C Stene
    Division of Epidemiology, Norwegian Institute of Public Health, P O Box 4404, Nydalen, NO 0403, Oslo, Norway
    Diabetologia 49:2068-73. 2006
    ....
  91. pmc HLA related genetic risk for coeliac disease
    Mathieu Bourgey
    INSERM U535, Universite Paris XI, Villejuif, France
    Gut 56:1054-9. 2007
    ..Several studies have shown an elevated prevalence of coeliac disease (CD) in sibs of coeliac patients (risk 8-12%)...
  92. ncbi Ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian multiple sclerosis patients
    S V Alves-Leon
    Neurology Department, Federal University of Rio de Janeiro State UNIRIO, Rio de Janeiro, Brazil
    Acta Neurol Scand 115:306-11. 2007
    ..The present study focused on human leukocyte antigen (HLA) DQB1, DQA1 and DRB1 allelic variation according to ethnicity and analyzed whether susceptibility to multiple sclerosis (MS) depends on population characteristics...
  93. doi Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies
    Ahmed J Delli
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    Pediatr Diabetes 11:513-20. 2010
    ..We also determined whether they have different human leukocyte antigen (HLA) genetic markers and islet autoantibodies at diagnosis compared with Swedish patients...
  94. pmc HLA genotyping in the international Type 1 Diabetes Genetics Consortium
    Josyf C Mychaleckyj
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    Clin Trials 7:S75-87. 2010
    ....
  95. ncbi HLA class II haplotypes associated with pulmonary interstitial lesions of polymyositis/dermatomyositis in Japanese patients
    T Horiki
    Department of Rheumatology and Hematology, Tokai University School of Medicine, Kanagawa, Japan
    Tissue Antigens 59:25-30. 2002
    ..0% vs 17.7%), and PM without PI (50.0% vs 5.5%). These results suggest that in terms of HLA class II association, Japanese DM and PM, and PM with and without PI, belong to different clinical groups...
  96. ncbi Triplet repeat polymorphism in the transmembrane region of the MICA gene in celiac disease
    L Fernandez
    Deparment of Immunology, San Carlos University Hospital, Madrid, Spain
    Tissue Antigens 59:219-22. 2002
    ..1 ancestral haplotype in strong linkage disequilibrium with MICA A5.1 allele...
  97. ncbi HLA class II antigens associated with lupus nephritis in Italian SLE patients
    Maurizio Marchini
    Clinical Immunology, University of Milan, and IRCCS Ospedale Maggiore, Milan, Italy
    Hum Immunol 64:462-8. 2003
    ..e., the most severe form of nephritis) is associated with the HLA-DR15 bearing haplotypes...
  98. ncbi Effect of propranolol and IFN-beta on the induction of MHC class II expression and cytokine production by IFN-gamma IN THP-1 human monocytic cells
    Q Li
    Department of Neurology, Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Immunopharmacol Immunotoxicol 20:39-61. 1998
    ....
  99. ncbi Gastric parietal cell antibodies are associated with glutamic acid decarboxylase-65 antibodies and the HLA DQA1*0501-DQB1*0301 haplotype in Type 1 diabetes mellitus. Belgian Diabetes Registry
    C E De Block
    Department of Endocrinology Diabetology, University Hospital Antwerp, Edegem, Belgium
    Diabet Med 17:618-22. 2000
    ..To assess the prevalence of thyrogastric autoimmunity in relation to age, sex, beta-cell antibody status and HLA DQ haplotypes in Type 1 diabetes mellitus...
  100. ncbi The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with function
    George P Bondinas
    Laboratory of Biochemistry and Biophysics, Faculty of Agricultural Technology, Epirus Institute of Technology, GR47100 Arta, Greece
    Immunogenetics 59:539-53. 2007
    ....
  101. ncbi Significance of the expression of major histocompatibility complex class II antigen, HLA-DR and -DQ, with recurrence of papillary thyroid cancer
    Young Suk Jo
    Division of Endocrinology, Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea
    Int J Cancer 122:785-90. 2008
    ..59 and 6.07, p = 0.03 and 0.01, respectively). In conclusion, PTC frequently expresses MHC Class II antigen, and the expression of MHC Class II antigen correlated inversely with the risk of recurrence of PTC...

Research Grants75

  1. Mechanisms for HLA-DQ mediated disease protection and susceptibility
    William W Kwok; Fiscal Year: 2012
    ..These observations will illuminate important early events in disease progression, providing a new biomarker and suggesting important new avenues for therapy. ..
  2. HLA-DQ Sequencing Studies in Narcolepsy/Hypocretin Deficiency
    Emmanuel J Mignot; Fiscal Year: 2012
    ..the newly developed FLX 454 titanium sequencing technique to generate and analyze high throughput, low cost full HLA DQA1 and DQB1 sequence, and to develop and perfect new statistical analytic tools, such as the Sequence Variant Type ..
  3. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2013
    ..abstract_text> ..
  4. Role of Elastolytic Cathepsins in Emphysema
    Harold A Chapman; Fiscal Year: 2010
    ..Identification of biomarkers of cathepsin S activity in COPD patients could :erve as a surrogate for disease progression and an in vivo measure of efficacy during drug trials. ..
  5. Steven A Porcelli; Fiscal Year: 2015
    ..The information gained will be applied to the design and construction of better vaccines for the prevention of tuberculosis. ..
  6. MHC Class II Antigen Processing and Immune Recognition of Melanoma
    KAREN TARASZKA HASTINGS; Fiscal Year: 2011
    ..The long-term goal of these studies is to aid the development of effective immunotherapy for melanoma. ..
  7. Inhibition of Antigen Presentation in Multiple Sclerosis
    Kai W Wucherpfennig; Fiscal Year: 2012
    ..We have discovered small molecules that substantially accelerate peptide binding to MHC class II molecules and will now examine their mechanism of action as well as therapeutic applications in humanized mouse models of MS. ..
  8. Michael B Brenner; Fiscal Year: 2014
    ..Further, we determine what regulates the process of how cells kill microbes by fusing the vesicles containing the organisms with vesicles that contain factors that can destroy the infections agents. ..
  9. Generation and Evaluation of Pro-Apoptotic rBCG and Viral Vectors as TB Vaccine C
    Thomas Evans; Fiscal Year: 2012
    ..We will evaluate these regimens in mice and rhesus macaques, models of TB vaccine immunology and efficacy with which we have extensive experience, to expediently select an optimal regimen. ..
  10. Structural Studies of IgE Receptors
    Theodore S Jardetzky; Fiscal Year: 2010
    ..abstract_text> ..
  11. Pamela A Wearsch; Fiscal Year: 2014
    ..These studies may also serve as a foundation for the future development of exosome-based diagnostics and therapeutics. ..
  12. Functional analyses of antiviral CD4+ T cell responses
    J Lindsay Whitton; Fiscal Year: 2013
    ..Might IFN[unreadable] be the "link" by which CD4+ T cells help the development of CD8+ T cell memory? Is the role of IFN[unreadable] the same for specific &non-specific CD4+ helper T cells? ..
  13. PEPTIDE BASED DELIVERY OF HIV IMMUNOGEN
    Lee Riley; Fiscal Year: 1999
    ..While this may be a high risk project, the yield, if shown to work, even as a method to enhance mammalian cell delivery of proteins, should have a significant impact. ..
  14. Functional Analysis of HCV-B Lymphocyte Interactions
    Thomas Chambers; Fiscal Year: 2003
    ..abstract_text> ..
  15. MODULATION OF CIITA BY CANNABINOIDS IN HUMAN MICROGLIA
    Debasish Sinha; Fiscal Year: 2004
    ..Microglia form the first line of defense during infection in the CNS and are involved in various immune diseases including AIDS. ..
  16. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2007
    ..abstract_text> ..
  17. MHC CLASS II INDUCTION IN ALLOGRAFT REJECTION
    Dilip Kittur; Fiscal Year: 1993
    ..This knowledge may be applied in the future to reduce immunogenicity of an allograft to circumvent rejection...
  18. IMMUNE FUNCTION IN ALLERGIC ENCEPHALOMYELITIS
    Robert Fritz; Fiscal Year: 2003
    ..1+ alpha/beta+ T cells by spectratypic analysis and nucleotide sequence, and 5) to analyze the interaction of NK1.1+ alpha/beta+ T cells with self-reactive T cells. ..
  19. CIITA REGULATION IN B LYMPHOCYTES AND MULTIPLE MYELOMA
    Kenneth Wright; Fiscal Year: 2003
    ..He also proposes to clone and characterize one of these factors using the yeast one-hybrid system or oligonucleotide screening of phage expression libraries. ..
  20. IMMUNOBIOLOGY OF TYPE I DIABETES
    Kevin Lafferty; Fiscal Year: 1992
    ....
  21. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  22. ROLE OF CATHEPSINS S, L AND B IN THE TYPE 1 DIABETES
    Alexander Rudensky; Fiscal Year: 2003
    ..This work will contribute to our understanding of the role of cathepsins in MHC class II antigen presentation, and provide new targets for downmodulating the immune responses leading to Type 1 diabetes. ..
  23. SCOTT MATTHEW WILLIAMS; Fiscal Year: 2016
    ..Our working hypothesis is that we will obtain more replicated and hence more real genetic associations using our novel bioinformatics methods that embrace, rather than ignore, prior biological knowledge. ..
  24. Gluten Sensitivity in the Old Order Amish
    Daniel McBride; Fiscal Year: 2005
    ..abstract_text> ..
  25. Jenny T Mao; Fiscal Year: 2015
    ..Findings from the study will provide important insights into the feasibility and mechanistic effects of GSE against lung cancer, help identify SEBM and set the stage for future clinical trials. ..
  26. Isolation of Genetic Suppressor Elements Against Hepatitis C Virus
    Zhilei Chen; Fiscal Year: 2010
    ..Novel anti-hepatitis C genetic suppressor elements isolated from this research will serve both as hepatitis C drugs, and as keys to open doors to new avenues of research in hepatitis C antiviral development. ..
  27. Prostate Cancer Prevention by Procyanidins in Grape Seed Extract
    Chapla Agarwal; Fiscal Year: 2012
    ..Outcomes of our proposed research will provide a mechanism-based agent for the prevention of prostate cancer in humans. ..
  28. Kequan Zhou; Fiscal Year: 2016
    ....
  29. Molecular Genetics of Regulated Protein Delivery of the Plasma Membrane
    CHRIS ALAN KAISER; Fiscal Year: 2010
    ..A final aim of the project is (iv) to understand how ubiquitination is regulated and to identify the cellular components required for recognition of the ubiquitin tag. ..
  30. IDENTIFICATION OF GENES THAT CONFER LPS SENSITIVITY
    Keiko Watanabe; Fiscal Year: 1999
    ..The ultimate goal of these studies is to develop novel therapeutic approaches based on increasing the resistance of host cells to the cytotoxic effects of LPS. ..
  31. MECHANSISM OF CELL GROWTH INHIBITION BY RNASE-L
    Bret Hassel; Fiscal Year: 2001
    ....
  32. STRESS INDUCED BYSTANDER EFFECT IN CANCER TREATMENT
    Andrei Gudkov; Fiscal Year: 2004
    ..abstract_text> ..
  33. Cognitive Effects of Grape Seed Extract-Brain Protein Targets
    Helen Kim; Fiscal Year: 2010
    ..The studies will define experimental parameters for future studies with GSE and related dietary supplements to assess mechanisms of action in models of human chronic disease. ..
  34. TUMOR CELL DEATH INDUCED BY INHIBITION OF REPLICATION
    Victor Levenson; Fiscal Year: 2000
    ..The isolated GSEs will also be tested for their effects on cellular response to replication-inhibiting chemotherapeutic drugs, to determine the role of replication-based mechanisms of cytotoxicity in their antitumor effect. ..
  35. Function-based selection of target genes in tumor cells
    IGOR RONINSON; Fiscal Year: 2005
    ..This analysis will provide a database of potential new targets for the development of anticancer drugs. ..
  36. Functional Activities of HCV Core Protein
    Ranjit Ray; Fiscal Year: 2005
    ....
  37. GENETIC ELEMENTS TRANSFORMING MOUSE FIBROBLASTS
    Andrei Gudkov; Fiscal Year: 2009
    ..The success of the proposed study will indicate development of a powerful target discovery tool that will be applicable for ACTT identification in other types of cancer. ..
  38. STRUCTURE & IMMUNOBIOLOGY OF IDDM PROTECTIVE MOLECULE
    William Kwok; Fiscal Year: 2000
    ..These studies address fundamental immune mechanisms, which account for dominant genetic protection, a major gap in our current understanding of the role of HLA genes in IDDM. ..
  39. GENETIC ELEMENTS SUPPRESSING P53
    Andrei Gudkov; Fiscal Year: 2000
    ..Using the GSE and two-hybrid approaches, the investigators hope to characterize new factors in the p53 pathway. ..
  40. Targeted antigens for novel strategies of vaccination
    STEPHEN HEDRICK; Fiscal Year: 2004
    ..More importantly, the experiments will lead to the design of a new generation of vaccines capable of directing the class and thus the effectiveness of immune responses. ..
  41. Nmb and melanosome function in eye pigment cells
    Michael Marks; Fiscal Year: 2005
    ..3. Determine the range of Nmb localization and splice variation in eye tissue of disease-free donors and pigmentary glaucoma patients. ..
  42. Iron and copper transporter trafficking in healthy and diseased melanocytes
    Michael Marks; Fiscal Year: 2007
    ..This proposal tests the hypothesis that Hermansky Pudlak Syndrome results from iron and copper dysregulation in the affected cell types. [unreadable] [unreadable] [unreadable]..
  43. Integrated Instrumentation for Proteomics
    Helen Kim; Fiscal Year: 2002
    ....
  44. MELANOSOME PROTEIN SORTING, FOLDING & ANTIGEN PROCESSING
    Michael Marks; Fiscal Year: 2002
    ..The effect of altering the protein sorting and/or retention properties of tyrosinase and gp100 on recognition by specific T cell clones will be determined. ..
  45. Identification of Measles Class II-Restricted Peptides
    INNA OVSYANNIKOVA; Fiscal Year: 2003
    ..The basis from which this proposal will build on is outlined in the background, significance, and preliminary data sections below. ..
  46. Chicago Childhood Diabetes Registry
    Rebecca Lipton; Fiscal Year: 2007
    ..Ultimately, this approach will permit a truly population-based molecular epidemiologic study of early-onset diabetes in families from a range of ethnic groups. ..
  47. DERMATITIS HERPETIFORMIS AND THE MUCOSAL IMMUNE RESPONSE
    Russell Hall; Fiscal Year: 2005
    ..These studies will provide insights into the pathogenesis of DH and isolated GSE, the relationship between the MIR and the skin and factors important in controlling the mucosal immune response in man. ..
  48. MALDI-TOF to Analyze KIR Association with HIV Disease
    Elizabeth Trachtenberg; Fiscal Year: 2006
    ..Data from this study will be critical to future studies examining the functional significance of KIR gene expression in HIV disease. [unreadable] [unreadable]..
  49. TOLL RECEPTORS IN MACROPHAGE & DENDRITIC CELL ACTIVATION
    Anne Stevens; Fiscal Year: 2003
    ....
  50. Prevention of Photocarcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2003
    ..abstract_text> ..
  51. Maternal Microchimerism in Renal Disease
    Anne Stevens; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  52. IMMUNOGENETIC MECHANISMS OF VACCINE RESPONSE
    Gregory A Poland; Fiscal Year: 2010
    ..The knowledge gained from these studies will enable us to design new strategies and new vaccines to protect human health against viral diseases. ..
  53. Enhancing Doctor-Patient Communication
    Stephanie Lee; Fiscal Year: 2006
    ..The project works towards the overall goal of enhancing communication, improving patient understanding, and facilitating psychosocial adaptation to life-threatening illness. ..
  54. RADIOIMMUNOTHERAPY OF B CELL LYMPHOMA WITH ANTI CD74
    M Mattes; Fiscal Year: 2002
    ..This study may lead to the development of more effective radio-conjugates for the therapy of cancer and other diseases. Also, it will provide basic information about the toxic effects of intracellular (really lysosomal) radionuclides. ..
  55. Tilting the balance in cancer immunotherapy and autoimmunity
    Wei Zen Wei; Fiscal Year: 2010
    ..Establish a vaccination regimen to inhibit spontaneous tumorigenesis and tumor metastasis, and 3. Amplify the immunogenicity of a growing tumor by in situ transfection with TetC DNA. ..
  56. Prevention of UV-carcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2004
    ..abstract_text> ..
  57. Epidemiology of Celiac Disease: A Population Based Study
    Joseph A Murray; Fiscal Year: 2010
    ..This will provide crucial data that will determine the need for early detection by screening and treatment of silent celiac disease, which may affect 1% of Americans. ..
  58. Proanthocyanidins: Novel Skin Cancer Preventive Agent
    Santosh Katiyar; Fiscal Year: 2006
    ..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
  59. HLA-DP SEQUENCE POLYMORPHISM AND DISEASE PREDISPOSITION
    Henry Erlich; Fiscal Year: 2003
    ..This method will be applied to HPV-infected cervical samples and an in vitro system with GAD peptide stimulation to study the HLA associations with cervical cancer and type 1 diabetes. ..
  60. International Congress of the Immunology of Diabetes Soc
    George Eisenbarth; Fiscal Year: 2002
    ..Travel grants for young investigators will be chosen by numerical rating of submitted abstracts and additional travel funding will be applied to plenary lectures chosen by the international organizing committee. ..
  61. Immunomodulation by MHC Class II Peptides
    Barbara Murphy; Fiscal Year: 2005
    ..These studies will help elucidate the potential role of MHC class II peptides in the prevention of transplant rejection and the induction of tolerance. ..
  62. Oxidative mutagenesis:Iron, Ascorbic Acid and Genes
    Christopher Bowlus; Fiscal Year: 2002
    ..They will use a mouse model of HH that is prone to hepatocellular formation. ..
  63. Disease concurrence in type 1 diabetes
    William Klitz; Fiscal Year: 2005
    ..Immune, endocrine and prenatal events will supply the functional background for interpreting age of onset, order of disease onset, gender and the relationship of infectious disease effects relative to T1D concurrence. ..
  64. Ovarian Cancer Detection Using H-NMR_Based Metabonomics
    Kunle Odunsi; Fiscal Year: 2006
    ..The proposed studies may lead to the identification of novel biomarkers for early detection of EOC, that will be evaluated further in prospective studies for early detection of EOC in general and high-risk populations. ..
  65. DQB1*0602 RELATIVES--MECHANISMS FOR DIABETES PROTECTION
    Carla Greenbaum; Fiscal Year: 2001
    ..This proposal includes collaborative agreements between the University of Washington and the Universities of Florida (Gainesville), South Florida (Tampa), and Colorado. ..
  66. Statistical Genetic Methods for Cancer Gene Studies
    Susan Slager; Fiscal Year: 2006
    ..abstract_text> ..
  67. Identification of Early Markers for Ovarian Cancer
    Anna Lokshin; Fiscal Year: 2006
    ..By the end of the proposed project, we expect to construct a test based on a panel of ovarian cancer-specific antigens that has the most promising characteristics to identify women with ovarian cancer. ..
  68. Prevention of skin cancer by green tea polyphenols
    Santosh Katiyar; Fiscal Year: 2009
    ..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
  69. The genetic basis of type 1 diabetes autoimmunity in African Americans
    Janelle Noble; Fiscal Year: 2008
    ..abstract_text> ..
  70. A HLA Mouse Model for Gluten Sensitivity and Enteropathy
    Joseph Murray; Fiscal Year: 2009
    ..abstract_text> ..
  71. Development of Rotational Fluctuation Spectroscopy for Biological Applications
    B Barisas; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  72. Inflammation and Ovarian Cancer
    Clareann Bunker; Fiscal Year: 2008
    ..In particular, NSAID use may prove to be a potentially important chemopreventative for this often-fatal disease. ..
  73. Tacrolimus and Plasmapheresis in Treatment-Resistant FSGS
    Tej Mattoo; Fiscal Year: 2007
    ..The proposed study will offer new treatment options in such patients and save many from the pain and the distress of undergoing dialysis and renal transplantation. [unreadable] [unreadable] [unreadable]..