HLA-C

Summary

Gene Symbol: HLA-C
Description: major histocompatibility complex, class I, C
Alias: D6S204, HLA-JY3, HLAC, HLC-C, MHC, PSORS1, HLA class I histocompatibility antigen, Cw-1 alpha chain, HLA class I histocompatibility antigen, C alpha chain, HLA-C alpha chain, HLA-C antigen, MHC class I antigen heavy chain HLA-C, human leukocyte antigen-C alpha chain, major histocompatibility antigen HLA-C
Species: human

Top Publications

  1. ncbi Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    S Mallal
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Perth, Australia
    Lancet 359:727-32. 2002
  2. doi Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection
    Danielle Van Manen
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AIDS 23:19-28. 2009
  3. pmc Additive contribution of HLA class I alleles in the immune control of HIV-1 infection
    Alasdair Leslie
    Weatherall Institute of Molecular Medicine, University of Oxford, UK
    J Virol 84:9879-88. 2010
  4. pmc A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
  5. pmc Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    Rajan P Nair
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 41:199-204. 2009
  6. ncbi Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties
    K Maenaka
    Structural Biology, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom
    J Biol Chem 274:28329-34. 1999
  7. pmc Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression
    Tumena W Corrah
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Virol 85:3367-74. 2011
  8. ncbi Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
    Susan M McKiernan
    Hepatology Center, St James s Hospital and Trinity College, Dublin, Ireland
    Hepatology 40:108-14. 2004
  9. ncbi HLA-Cw8 primarily associated with hypersensitivity to nevirapine
    Hiroyuki Gatanaga
    AIDS 21:264-5. 2007
  10. pmc HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells
    Malinda R Schaefer
    Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Pathog 4:e1000131. 2008

Research Grants

  1. Philip J Goulder; Fiscal Year: 2014
  2. JAMES TILFORD ELDER; Fiscal Year: 2016
  3. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    Jianming Tang; Fiscal Year: 2012
  4. High-Throughput HLA-Typing: on Raw, Unpurified Cord Blood Samples
    Michael E Hogan; Fiscal Year: 2013
  5. PETER R PARHAM; Fiscal Year: 2016
  6. Identification of Psoriatic Arthritis Genes
    JAMES TILFORD ELDER; Fiscal Year: 2013
  7. IDENTIFICATION OF HLA MRNA REGULATORY ELEMENTS
    JANE MCCUTCHEON; Fiscal Year: 2000
  8. Innate Immunity and SIV Infection
    Aftab A Ansari; Fiscal Year: 2013
  9. ROGER KEITH REEVES; Fiscal Year: 2014
  10. HCV resolution correlates with patterned KIR expressions on lymphocytes.
    James C Ryan; Fiscal Year: 2013

Detail Information

Publications281 found, 100 shown here

  1. ncbi Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    S Mallal
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Perth, Australia
    Lancet 359:727-32. 2002
    ..Genetic factors influencing the immune response to abacavir might confer susceptibility. We aimed to find associations between MHC alleles and abacavir hypersensitivity in HIV-1-positive individuals treated with abacavir.
  2. doi Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection
    Danielle Van Manen
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    AIDS 23:19-28. 2009
    ....
  3. pmc Additive contribution of HLA class I alleles in the immune control of HIV-1 infection
    Alasdair Leslie
    Weatherall Institute of Molecular Medicine, University of Oxford, UK
    J Virol 84:9879-88. 2010
    ..Taken together, these data suggest that although individual HLA alleles, particularly HLA-B, can have a strong impact, HIV control overall is likely to be influenced by the additive effect of some or all of the other HLA alleles present...
  4. pmc A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
    ..These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents...
  5. pmc Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    Rajan P Nair
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 41:199-204. 2009
    ..Our results expand the catalog of genetic loci implicated in psoriasis susceptibility and suggest priority targets for study in other auto-immune disorders...
  6. ncbi Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties
    K Maenaka
    Structural Biology, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom
    J Biol Chem 274:28329-34. 1999
    ..a repertoire of killer cell immunoglobulin receptors (KIRs) that recognize major histocompatibility complex (MHC) class I molecules...
  7. pmc Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression
    Tumena W Corrah
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Virol 85:3367-74. 2011
    ..We suggest that association of the -35 SNP and HIV-1 load manifests as a result of linkage disequilibrium of this polymorphism with both favorable and unfavorable HLA-C and -B alleles...
  8. ncbi Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
    Susan M McKiernan
    Hepatology Center, St James s Hospital and Trinity College, Dublin, Ireland
    Hepatology 40:108-14. 2004
    ..More significantly, either HLA-A*03, -DRB1*0101, or -*0401 are carried by an overwhelming majority of those subjects who successfully clear HCV...
  9. ncbi HLA-Cw8 primarily associated with hypersensitivity to nevirapine
    Hiroyuki Gatanaga
    AIDS 21:264-5. 2007
  10. pmc HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells
    Malinda R Schaefer
    Graduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS Pathog 4:e1000131. 2008
    ..expression of the viral receptor (CD4) and molecules capable of presenting HIV antigens to the immune system (MHC-I)...
  11. pmc HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation
    Isobella Honeyborne
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 84:11279-88. 2010
    ....
  12. pmc HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer
    Maureen P Martin
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc NCI Frederick, Frederick, MD 21702, USA
    Immunogenetics 62:761-5. 2010
    ..008). These data support the involvement of the HLA-C locus in modulating the risk of cervical neoplasia perhaps through its function as ligands for KIR, but functional studies are essential to confirm this hypothesis...
  13. pmc HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements
    Jolie A Leonard
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA
    J Virol 85:6867-81. 2011
    ..The best-characterized targets of Nef are major histocompatibility complex class I (MHC-I) and CD4, but Nef also has been reported to target several other proteins, including CD8β, CD28, CD80, CD86, and ..
  14. doi Rising HIV-1 viral load set point at a population level coincides with a fading impact of host genetic factors on HIV-1 control
    Danielle Van Manen
    Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infectious Diseases and Immunity Amsterdam at the Academic Medical Center of the University of Amsterdam, The Netherlands
    AIDS 25:2217-26. 2011
    ..Here we studied whether this increase coincides with a fading impact of above-mentioned host genetic markers on HIV-1 control...
  15. ncbi Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 186:598-605. 2002
    ..Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia...
  16. pmc HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes
    J D Weissman
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:11601-6. 1998
    HIV Tat, a transactivator of viral transcription, represses transcription of major histocompatibility (MHC) class I genes...
  17. pmc HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Diabetes 59:2972-9. 2010
    ..We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study...
  18. ncbi Targeting HIV-1 Gag into the defective ribosomal product pathway enhances MHC class I antigen presentation and CD8+ T cell activation
    Andreas Goldwich
    Institute of Clinical and Molecular Virology, Department of Dermatology, University Hospital of Erlangen, Germany
    J Immunol 180:372-82. 2008
    The main source for endogenous peptides presented by the MHC class I (MHC-I) pathway are de novo-synthesized proteins which are degraded via the ubiquitin proteasome pathway...
  19. pmc Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationships
    Jianming Tang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e9629. 2010
    ..Immunogenetic research has established various human genetic factors, especially human leukocyte antigen (HLA) variants, as independent determinants of VL set-point...
  20. doi Class I HLA-A*7401 is associated with protection from HIV-1 acquisition and disease progression in Mbeya, Tanzania
    Rebecca N Koehler
    US Military HIV Research Program, Henry M Jackson Foundation, Rockville, Maryland 20850, USA
    J Infect Dis 202:1562-6. 2010
    ..This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection...
  21. pmc Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef
    Richard D Sloan
    McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, H3T 1E2 Canada
    J Virol 85:2828-36. 2011
    ..HIV-1 cDNAs could result in Nef-mediated modulation of cell surface major histocompatibility complex class I (MHC-I) expression...
  22. ncbi Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules
    R Biassoni
    Istituto Nazionale per la Ricerca sul Cancro and Centro Biotecnologie Avanzate, Genova, Italy
    Eur J Immunol 27:3095-9. 1997
    ..1/p50.1 affinity for their HLA-C ligand and suggests a possible role of position 70 as a contact site in the natural killer cell receptor/major histocompatibility complex class I interaction...
  23. pmc Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa
    Zabrina Brumme
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, USA
    Clin Infect Dis 49:956-64. 2009
    ....
  24. ncbi MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studies
    M Malkki
    The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Tissue Antigens 66:114-24. 2005
    Twenty-two human major histocompatibility complex (MHC) region microsatellite (Msat) markers were studied for diversity and linkage disequilibrium (LD) with HLA loci in hematopoietic cell transplant recipients and their HLA-A, HLA-B, HLA-..
  25. ncbi Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme
    Jianming Tang
    Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 220A, Birmingham, AL 35294 0022, USA
    Cancer Epidemiol Biomarkers Prev 14:2040-4. 2005
    ..B*07 and the B*07-Cw*07 haplotype are much more common in Caucasians than other ethnic groups in the U.S., which may partially explain the higher incidence of glioblastoma multiforme in Caucasians...
  26. ncbi Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese
    Mayumi Ueta
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi, Kyoto, Japan
    Am J Ophthalmol 143:367-8. 2007
    ..To investigate the association between HLA class I antigens and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with ocular complications in Japanese...
  27. ncbi Haplotype associations of the major histocompatibility complex with psoriasis in Northeastern Thais
    Charoen Choonhakarn
    Division of Dermatology, Department of Medicine, Faculty of Medicine, and Blood Transfusion Center, Khon Kaen University, Khon Kaen 40002, Thailand
    Int J Dermatol 41:330-4. 2002
    ..To evaluate the distributions of the human leukocyte antigen (HLA) at class I and II loci that may contribute to the genetic susceptibility to psoriasis patients in the north-eastern Thai population...
  28. ncbi Correlation of HLA-Cw*06 allele frequency with some clinical features of psoriasis vulgaris in the population of northern Poland
    Aneta Szczerkowska-Dobosz
    Department of Dermatology, Venerology and Allergology, Medical University, Debinki 7, 80 211 Gdansk, Poland
    J Appl Genet 45:473-6. 2004
    ..Our investigation confirms that the Cw*06 allele is positively associated with psoriasis vulgaris of the early onset type, with a positive family history and its more severe form...
  29. ncbi Psoriasis vulgaris and human leukocyte antigens
    F F Cassia
    School of Medicine, Clementino Fraga Filho University Hospital, Post Graduation Course of Dermatology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Eur Acad Dermatol Venereol 21:303-10. 2007
    ..The association of human leukocyte antigens (HLA) and psoriasis has long been reported on population and familial studies...
  30. pmc HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Proc Natl Acad Sci U S A 102:4134-9. 2005
    ..The initial screen revealed strong association between allopurinol-SCAR and SNPs in the MHC region, including BAT3 (encoding HLA-B associated transcript 3), MSH5 (mutS homolog 5), and MICB (MHC class I ..
  31. doi Behavior of non-classical soluble HLA class G antigens in human immunodeficiency virus 1-infected patients before and after HAART: comparison with classical soluble HLA-A, -B, -C antigens and potential role in immune-reconstitution
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Clin Immunol 133:238-44. 2009
    ....
  32. ncbi Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells
    Jennifer Hirst
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK
    Traffic 10:1696-710. 2009
    ..In contrast, downregulation of major histocompatibility complex (MHC) class I by HIV-1 Nef, which requires AP-1, was not affected by a triple GGA knockdown...
  33. pmc A noncanonical mu-1A-binding motif in the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes
    Sayuki Iijima
    Laboratory of Disease Control, Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Hachimandai, Tsukuba shi, Ibaraki, Japan
    J Virol 86:3944-51. 2012
    Downregulation of major histocompatibility complex class I (MHC-I) by HIV-1 Nef protein is indispensable for evasion of protective immunity by HIV-1...
  34. pmc The human immunodeficiency virus type 1 Nef and Vpu proteins downregulate the natural killer cell-activating ligand PVR
    Giulia Matusali
    Laboratory of Immunoinfectivology, Bambino Gesu Children s Hospital, IRCCS, Rome, Italy
    J Virol 86:4496-504. 2012
    ....
  35. ncbi MICA 5.1 allele is a susceptibility marker for psoriasis in the Korean population
    H B Choi
    Catholic Hemopoietic Stem Cell Bank, Seoul, Korea
    Tissue Antigens 56:548-50. 2000
    ..1 allele might be a genetic marker related to the early onset of psoriasis and play a secondary role to the HLA-Cw*0602 gene or an unknown causative gene closely linked to HLA-Cw*0602 in the genetic susceptibility to psoriasis...
  36. ncbi Analysis of the frequencies of HLA-A, B, and C alleles and haplotypes in the five major ethnic groups of the United States reveals high levels of diversity in these loci and contrasting distribution patterns in these populations
    K Cao
    American Red Cross National Histocompatibility Laboratory, Baltimore, Maryland, USA
    Hum Immunol 62:1009-30. 2001
    ..Differences in both LD and heterozygosity levels suggest distinct evolutionary histories of the HLA loci in the geographical regions from where the U.S. populations originated...
  37. pmc Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking
    Maya Williams
    Graduate Program in Cellular and Molecular Biology, University of Michigan University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    J Virol 76:12173-84. 2002
    ..virus type 1, has multiple functions that include disruption of major histocompatibility complex class I molecules (MHC-I) and CD4 and CD28 cell surface expression...
  38. ncbi Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort
    Shu Li
    Vaccine Laboratory, Nankai University, Tianjin, China
    J Acquir Immune Defic Syndr 44:121-31. 2007
    ..These data contribute to the database of allele frequencies and associations with HIV infection in the Chinese population...
  39. ncbi Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand
    J C Boyington
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Nature 405:537-43. 2000
    Target cell lysis is regulated by natural killer (NK) cell receptors that recognize class I MHC molecules...
  40. ncbi HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway
    Anastassia D Blagoveshchenskaya
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Cell 111:853-66. 2002
    The HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the trans-Golgi network (TGN) enables HIV-1 to escape immune surveillance. However, the cellular pathway used by Nef to downregulate MHC-I is unknown...
  41. ncbi Locus-specific constitutive and cytokine-induced HLA class I gene expression
    David R Johnson
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 170:1894-902. 2003
    Cytokine induction of the MHC class I genes increases the nascent molecules available for binding potentially antigenic peptides. The human H chain loci, HLA-A, -B, and -C, encode highly homologous and polymorphic mRNAs...
  42. ncbi Psoriasis vulgaris and psoriatic arthritis share a 100 kb susceptibility region telomeric to HLA-C
    J Martinez-Borra
    Department of Immunology, Hospital Central de Asturias, Oviedo, Spain
    Rheumatology (Oxford) 42:1089-92. 2003
    ..To map the locus for susceptibility to psoriasis in patients with psoriatic arthritis...
  43. ncbi Distinct HLA-C/KIR genotype profile associates with guttate psoriasis
    Sofia J Holm
    Unit of Dermatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Invest Dermatol 125:721-30. 2005
    ..KIR's function is triggered by specific binding to HLA ligands, which depends on the amino acid 80 of the MHC class I alpha-chain...
  44. ncbi Segregation of HLA-C from ICAM-1 at NK cell immune synapses is controlled by its cell surface density
    Catarina R Almeida
    Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom
    J Immunol 177:6904-10. 2006
    ..e., 10(4)/cell surface), a multifocal patterning of MHC class I protein predominated, whereas for higher levels of expression (10(5)/cell surface), clusters of HLA-C were ..
  45. pmc HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2
    Nienke B Lubben
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom
    Mol Biol Cell 18:3351-65. 2007
    ..of human immunodeficiency virus (HIV)-1-infected cells by Nef, a virally encoded protein that is thought to reroute MHC-I to the trans-Golgi network (TGN) in a phosphofurin acidic cluster sorting protein (PACS) 1, adaptor protein (AP)-..
  46. doi Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage
    S E Hiby
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Hum Reprod 23:972-6. 2008
    ..Pre-eclampsia and recurrent miscarriage (RM) share the pathogenesis of defective placentation and therefore we have now genotyped couples with RM...
  47. doi Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals
    R D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, CA 90095 1652, USA
    Genes Immun 9:249-58. 2008
    ....
  48. doi Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  49. pmc The HLA-B/-C haplotype block contains major determinants for host control of HIV
    E Trachtenberg
    Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Genes Immun 10:673-7. 2009
    ....
  50. pmc A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
    Amy Strange
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nat Genet 42:985-90. 2010
    ..95 × 10⁻⁶). ERAP1 plays an important role in MHC class I peptide processing...
  51. doi KIR genes and their human leukocyte antigen ligands in the progression to cirrhosis in patients with chronic hepatitis C
    Amanda Vansan Marangon
    Immunogenetics Laboratory, Department of Basic Sciences, Maringa State University, UEM, Maringa, Parana, Brazil
    Hum Immunol 72:1074-8. 2011
    ..7%, p = 0.06) and in the F4 group compared with the F0-F3 group (65.7% vs 46.7%, p = 0.05, OR = 2.19, 95% CI = 1.01-4.73). NK and KIR ligands may contribute to the development of liver damage in patients chronically infected by HCV...
  52. pmc Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix
    Lillian S Kuo
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y9 206, Dallas, TX 75390, USA
    Retrovirology 9:47. 2012
    ..Further, mutation of the non-motif "X" residues, (Q73, V74, and L75) would give altered patterns of inhibition for different Nef/SH3 domain protein interactions...
  53. ncbi HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway
    S A Swann
    Departments of Medicine and Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Virology 282:267-77. 2001
    ..Nef causes a reduction in the level of cell surface major histocompatibility complex class I (MHC-I) protein expression, thus protecting HIV-infected cells from anti-HIV cytotoxic T lymphocyte (CTL) recognition ..
  54. ncbi Polymorphism in MICA rather than HLA-B/C genes is associated with psoriatic arthritis in the Jewish population
    S Gonzalez
    Functional Biology Department, University of Oviedo, Asturias, Spain
    Hum Immunol 62:632-8. 2001
    ..These results suggest that the MICA gene or other nearby gene(s) may be involved in the development of PsA, and it would thus appear that psoriasis vulgaris (PsV) and PsA are associated with different MHC susceptibility genes.
  55. doi KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease
    Ralph D Levinson
    Ocular Inflammatory Disease Center, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA
    Hum Immunol 69:349-53. 2008
    ..The trends observed in this study are consistent with those reported for other autoimmune diseases...
  56. doi Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome
    David P Lowe
    Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Vincent Drive, Edgbaston, Birmingham, UK
    Rheumatology (Oxford) 48:359-62. 2009
    ....
  57. ncbi Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis
    R C Trembath
    Department of Genetics, University of Leicester, UK
    Hum Mol Genet 6:813-20. 1997
    ..005) and markers from the MHC region at 6p21 (p <0...
  58. ncbi HLA polymorphism in the Murcia population (Spain): in the cradle of the archaeologic Iberians
    M Muro
    Service of Immunology, University Hospital Virgen de la Arrixaca, Murcia, Spain
    Hum Immunol 62:910-21. 2001
    ..Thus, Murcian population seems to belong to the European genetic pool, revealing a lesser genetic distance with the North Africans and the rest of populations from the Iberian Peninsula...
  59. ncbi HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes
    Sari Suomela
    Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland
    J Invest Dermatol 121:1360-4. 2003
    We have previously shown that HCR is a good candidate gene for psoriasis based on its location in the PSORS1 locus, predicted secondary structure change of the associated allele, and expression pattern...
  60. ncbi Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome
    Neal Flomenberg
    Department of Medicine and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Blood 104:1923-30. 2004
    ..When clinical circumstances allow, high-resolution class I typing may help optimize donor selection and improve outcome...
  61. ncbi HLA Cw*06 is not essential for streptococcal-induced psoriasis
    L Fry
    Faculty of Medicine, Imperial College, London, UK, and The Skin Hospital, Dublin 2, Ireland
    Br J Dermatol 154:850-3. 2006
    ..Streptococcal throat infections and HLA Cw6 (Cw*06) have been implicated in the pathogenesis of psoriasis, particularly in the guttate form...
  62. ncbi Association of HLA-A, -B, -C genes and TNF microsatellite polymorphism with psoriasis vulgaris: a study of genetic risk in Brazilian patients
    A C Biral
    Immunogenetic Transplant Laboratory, Clinical Pathology Department, School of Medical Science, Rua Gustavo Rodrigues Dória, 255, 13083 060 Campinas, SP, Brazil
    Eur J Dermatol 16:523-9. 2006
    ..Our results detected polymorphisms of the HLA class I and microsatellite TNF locus which could be markers of genetic predisposition to the disease...
  63. pmc A second major histocompatibility complex susceptibility locus for multiple sclerosis
    Tai Wai Yeo
    Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ann Neurol 61:228-36. 2007
    Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA-DRB1 gene in the class II region...
  64. pmc ADAM33, a new candidate for psoriasis susceptibility
    Fabienne Lesueur
    Centre National de Genotypage, Evry, France
    PLoS ONE 2:e906. 2007
    ..In addition to unambiguous linkage to the major susceptibility locus PSORS1 on Chromosome 6p21, we provided evidence for a susceptibility locus on Chromosome 20p13...
  65. pmc Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population
    Xing Fan
    Institute of Dermatology and Department of Dermatology at No 1 Hospital, Anhui Medical University, Hefei, Anhui, China
    PLoS Genet 4:e1000038. 2008
    b>PSORS1 (psoriasis susceptibility gene 1) is a major susceptibility locus for psoriasis. Several fine-mapping studies have highlighted a 300-kb candidate region of PSORS1 where multiple biologically plausible candidate genes were suggested...
  66. ncbi Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients
    Hsien Tzung Liao
    Taipei Medical University, Municipal Wan Fang Hospital, Hualien, Taiwan
    J Rheumatol 35:891-5. 2008
    ..We conducted a retrospective study to determine the human leukocyte antigen (HLA) -A, -B, -Cw, -DR, and -DQ alleles in Chinese patients with PsA and psoriasis...
  67. pmc Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3359-66. 2009
    ....
  68. ncbi HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2)
    A Steinle
    Institute of Immunology, University of Munich, Germany
    Tissue Antigens 44:268-70. 1994
  69. ncbi The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane
    A Mangasarian
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Immunity 6:67-77. 1997
    The HIV Nef protein down-regulates the cell surface expression of CD4 and of MHC I at least in part through accelerated endocytosis...
  70. ncbi Reduced cell surface expression of HLA-C molecules correlates with restricted peptide binding and stable TAP interaction
    A Neisig
    Department of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam
    J Immunol 160:171-9. 1998
    ..The restricted peptide binding of certain HLA-C alleles provides one explanation for the reduced expression of HLA-C molecules at the cell surface. Other mechanisms will be discussed...
  71. pmc The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    M E Greenberg
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    EMBO J 17:2777-89. 1998
    ..protein of human and simian immunodeficiency viruses, downregulates cell surface expression of both class I MHC and CD4 molecules in T cells by accelerating their endocytosis...
  72. pmc Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
    H Akari
    Department of Virology, The University of Tokushima School of Medicine, Tokushima, Tokushima 770 8503, Japan
    J Virol 74:2907-12. 2000
    ..infectivity, virion incorporation of Nef, and the down-regulation of major histocompatibility complex class I (MHC-I) expression on cell surfaces...
  73. ncbi Differential expression of human major histocompatibility class I loci: HLA-A, -B, and -C
    D R Johnson
    Department of Pathology and the Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Hum Immunol 61:389-96. 2000
    Expression of the human class I MHC loci, HLA-A, -B, and -C, was examined by reverse transcription and competitive PCR with locus-specific primers...
  74. pmc Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation
    S Le Gall
    Unité Rétrovirus et Transfert Génétique, URA CNRS 1930, France
    J Virol 74:9256-66. 2000
    ..immunodeficiency virus type 1 Nef protein alters the post-Golgi stages of major histocompatibility complex class I (MHC-I) biogenesis...
  75. ncbi Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Nat Immunol 2:452-60. 2001
    ..down-regulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells...
  76. pmc Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at PSORS1, the major psoriasis-susceptibility locus
    Colin D Veal
    Division of Medical Genetics, University of Leicester, Leicester, LE1 7RH, United Kingdom
    Am J Hum Genet 71:554-64. 2002
    ..Genomewide scans for disease susceptibility have repeatedly demonstrated the existence of a major locus, PSORS1 (psoriasis susceptibility 1), contained within the major histocompatibility complex (MHC), on chromosome 6p21...
  77. ncbi Association of HLA class I alleles with psoriasis vulgaris in southeastern Chinese Hans
    Xue Jun Zhang
    Institute of Dermatology, Anhui Medical University, No 69 Meishan Road, Hefei, Anhui 230032, PR China
    J Dermatol Sci 33:1-6. 2003
    ..Predisposing genetic factors in psoriasis include associations with human leukocyte antigen (HLA). Accumulative evidence has shown that certain HLA at class I locus, especially HLA-Cw6, are associated closely with psoriasis...
  78. ncbi Human leukocyte antigen-A, -B, and -Cw polymorphism in a Berber population from North Morocco using sequence-based typing
    D Piancatelli
    C N R Istituto per i Trapianti d Organo e l Immunocitologia, L Aquila, Italy
    Tissue Antigens 63:158-72. 2004
    ..Nevertheless, this study highlights some unique genetic traits of the ME population compared to other ethnic groups within Morocco, which could be of great interest for clinical aims, transplantation, and diseases...
  79. ncbi Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci
    K Cao
    Department of Oncology, Georgetown University, Washington, DC, USA
    Tissue Antigens 63:293-325. 2004
    ....
  80. ncbi Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples
    M Tevfik Dorak
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Lancet 363:2137-9. 2004
    ..23, 95% CI 1.52-3.26, p<0.0001). Selective pressure by HLA-B alleles on transmitted viruses accords with current understanding of the effect of B locus polymorphism in HIV-1 and perhaps other infections...
  81. ncbi Haplotype sharing analysis identifies a retroviral dUTPase as candidate susceptibility gene for psoriasis
    John Foerster
    Klinik fur Dermatologie, Charite, Schumannstr, Berlin, Germany
    J Invest Dermatol 124:99-102. 2005
    The psoriasis susceptibility locus 1 (PSORS1) mutation is assumed to reside within a region around human leukocyte antigen-C spanning 250 kb, termed risk haplotype (RH) 1/2...
  82. ncbi The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis
    Michael Hugh Allen
    St John s Institute of Dermatology, Kings College London, London, UK
    J Invest Dermatol 124:103-6. 2005
    b>PSORS1 is the major susceptibility locus for psoriasis vulgaris (PV) and lies within an approximately 200 kb segment of the major histocompatibility complex on chromosome 6p21.3...
  83. ncbi Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR
    Cynthia Helms
    Department of Genetics, Washington University School of Medicine, Box 8232, 4566 Scott Avenue, St Louis, Missouri, 63110, USA
    Hum Genet 118:466-76. 2005
    ..Associations with alleles from the HLA class I region (now known as PSORS1), particularly HLA-Cw*0602, were described over 20 years ago...
  84. ncbi Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients--an analysis of 1019 HLA-C- and HLA-B-typed patients
    Johann E Gudjonsson
    National University Hospital of Iceland, Reykjavik
    J Invest Dermatol 126:740-5. 2006
    ..Our findings indicate that the genetic factor on chromosome 6 has a strong influence on the phenotype of the disease, and underline that differences in clinical features of psoriasis may be to a large extent genetically determined...
  85. ncbi Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility
    D C Jones
    Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, UK
    Genes Immun 7:576-82. 2006
    ..019). These results suggest that KIR genotype and HLA ligand interaction may contribute to the genetic susceptibility of UC...
  86. ncbi HLA alleles in pre-menopausal breast cancer patients from western India
    L Gopalkrishnan
    Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer ACTREC, Tata Memorial Centre, Khraghar, Navi Mumbai, India
    Indian J Med Res 124:305-12. 2006
    ..Therefore, we undertook this study to assess the possibility of association of HLA-class I alleles in pre-menopausal breast cancer patients...
  87. pmc HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritis
    Pauline Y P C Ho
    ARC EU, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 66:807-11. 2007
    ..Human leucocyte antigen (HLA) genes predict disease severity in psoriasis (HLA-Cw6) and rheumatoid arthritis (shared epitope (SE)), but the situation is unclear for psoriatic arthritis (PsA)...
  88. ncbi Role of Nef in HIV-1 replication and pathogenesis
    John L Foster
    Department of Internal Medicine, University of Texas Southwestern, Medical Center, Dallas, TX 75390, USA
    Adv Pharmacol 55:389-409. 2007
  89. ncbi Variants in the 5q31 cytokine gene cluster are associated with psoriasis
    M Chang
    Celera, Alameda, CA 94502, USA
    Genes Immun 9:176-81. 2008
    ....
  90. pmc Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene
    Francesca Capon
    Division of Genetics and Molecular Medicine, Infection and Inflammatory Disease, King s College London, London, UK
    Hum Mol Genet 17:1938-45. 2008
    ..have clearly identified a primary disease susceptibility locus lying within the major histocompatibility complex (MHC), but have generated conflicting results for other genomic regions...
  91. doi Role of Nef in primate lentiviral immunopathogenesis
    F Kirchhoff
    Institute of Virology, University of Ulm, 89081 Ulm, Germany
    Cell Mol Life Sci 65:2621-36. 2008
    ..This evolutionary loss of a specific Nef function may contribute to the high virulence of HIV-1 in humans...
  92. doi Donor HLA-C genotype has a profound impact on the clinical outcome following liver transplantation
    R Hanvesakul
    Department of Nephrology and Transplantation, University Hospital Birmingham, Edgbaston, Birmingham, UK
    Am J Transplant 8:1931-41. 2008
    ..Modulation of HLA-C and KIR interactions represents an important novel approach to promote long-term graft and patient survival...
  93. doi HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients
    Soranun Chantarangsu
    Research Group for Pharmacogenomics, RIKEN, Center for Genomic Medicine, Tokyo, Japan
    Pharmacogenet Genomics 19:139-46. 2009
    ..Investigation of a possible involvement of differences in human leukocyte antigens (HLA) in the risk of nevirapine (NVP)-induced skin rash among HIV-infected patients...
  94. doi Role of HIV-1 Nef protein for virus replication in vitro
    Abhay Jere
    Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Microbes Infect 12:65-70. 2010
    ..This review summarizes and organizes current knowledge of HIV-1 Nef with respect to this particularly virological activity for understanding the basis of its in vivo function...
  95. pmc Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs
    Wei Song
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 4:e7157. 2009
    ..In a previous study, several HLA-B and HLA-C alleles and haplotypes were positively or negatively associated with the occurrence and prognosis of glioblastoma multiforme (GBM)...
  96. pmc Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand
    Jill A Hollenbach
    Center for Genetics, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Immunogenetics 61:663-71. 2009
    ..These results show for the first time that disease susceptibility may be related to heterozygosity at a specific KIR locus, and that HLA ligand genotype influences the relative effect of the KIR genotype...
  97. pmc Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
    Eva Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Nat Genet 42:991-5. 2010
    ..TRAF3IP2 encodes a protein involved in IL-17 signaling and which interacts with members of the Rel/NF-κB transcription factor family...
  98. pmc Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge, UK
    J Clin Invest 120:4102-10. 2010
    ..These findings highlight the complexity and central importance of specific combinations of activating KIR and HLA-C in maternal-fetal immune interactions that determine reproductive success...
  99. pmc Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo
    Martha J Lewis
    Department of Medicine, Division of Infectious Diseases, Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Virol 86:7126-35. 2012
    Human immunodeficiency virus type 1 (HIV-1) Nef downregulates major histocompatibility complex class I (MHC-I), impairing the clearance of infected cells by CD8(+) cytotoxic T lymphocytes (CTLs)...
  100. pmc Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef
    Xiaofei Jia
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Nat Struct Mol Biol 19:701-6. 2012
    The HIV-1 protein Nef inhibits antigen presentation by class I major histocompatibility complex (MHC-I)...
  101. doi Dynamic range of Nef functions in chronic HIV-1 infection
    Philip Mwimanzi
    Center for AIDS Research, Kumamoto University, Kumamoto, Japan
    Virology 439:74-80. 2013
    ..Strong functional co-dependencies and the polyfunctional nature of patient-derived Nef sequences suggest a phenotypic requirement to maintain multiple Nef functions during chronic infection...

Research Grants66

  1. Philip J Goulder; Fiscal Year: 2014
    ..The novel approach, involved use of peptide-MHC tetramers, is rapid and inexpensive, has been validated by us as shown in preliminary data presented, and crucially ..
  2. JAMES TILFORD ELDER; Fiscal Year: 2016
    ..We have mapped PSORS1, the major psoriasis susceptibility gene in the major histocompatibility complex (MHC), to within or very near HLA-..
  3. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    Jianming Tang; Fiscal Year: 2012
    ....
  4. High-Throughput HLA-Typing: on Raw, Unpurified Cord Blood Samples
    Michael E Hogan; Fiscal Year: 2013
    ..That "Raw Guthrie Card" HLA-Typing would then be compared, in terms of accuracy &cost, to that obtained by current methods of HLA-Typing on purified DNA. ..
  5. PETER R PARHAM; Fiscal Year: 2016
    ..reproduction are variable receptors that recognize polymorphic determinants of major histocompatibility complex (MHC) class I molecules...
  6. Identification of Psoriatic Arthritis Genes
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..However, substantial literature suggests that in addition to HLA-Cw6, there may be other MHC associations in PsA, particularly with HLA-B38 and -B39. In our 2003 submission, we described a 9...
  7. IDENTIFICATION OF HLA MRNA REGULATORY ELEMENTS
    JANE MCCUTCHEON; Fiscal Year: 2000
    ..These studies will increase our understanding of immune regulation. ..
  8. Innate Immunity and SIV Infection
    Aftab A Ansari; Fiscal Year: 2013
    ..fact that the kinetics are also faster in SIV-infected long term non-progressor rhesus macaques as compared with MHC haplotype identical SIV-infected regular progressor rhesus macaques underscores the importance of this finding...
  9. ROGER KEITH REEVES; Fiscal Year: 2014
    ....
  10. HCV resolution correlates with patterned KIR expressions on lymphocytes.
    James C Ryan; Fiscal Year: 2013
    ..These studies also will help to identify KIR as attractive drug targets for pharmacologic antiviral therapies. ..
  11. HIV Evasion of NK Cells in Lymph Nodes
    Allan R Tenorio; Fiscal Year: 2010
    ..g., major histocompatibility molecules (MHC) class I molecules] that provide inhibitory signals to NK cells (i.e...
  12. Genotyping the NPF Biobank for Psoriasis Susceptibility Genes
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..This analysis will fine-map PSORS1 and the other confirmed psoriasis loci, and will test ~5,000 additional promising genetic signals from the initial ..
  13. High Resolution Multiplexed DNA reverse-SSO Typing Assay
    Jar How Lee; Fiscal Year: 2007
    ..Following validation testing and regulatory clearance, a complete line of superior HLA and KIR typing products will be available to the NMDP and HLA laboratories. ..
  14. NK/DC Cross-Talk and Antiviral Response
    Luis J Montaner; Fiscal Year: 2011
    ..As the rate of response to therapy varies from about 60% in mono-infection to <25% in HIV/HCV co-infected individuals, it is imperative that added research be conducted in understanding clearance mechanisms. ..
  15. Thaddeus G Golos; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The unique expression of MHC class I molecules HLA-G and particularly HLA-C in extravillous trophoblasts is thought to be a critical element of human pregnancy...
  16. High Performance Magnetic Cell Sorting
    JEFFREY CHALMERS; Fiscal Year: 2006
    ..abstract_text> ..
  17. Custon Designing Peptides for Cancer Immunotherapy
    Douglas Lake; Fiscal Year: 2005
    ..In future studies, we intend to expand this multi-allelic approach to include other tumor associated antigens. ..
  18. CHEMISTRY AND BIOLOGY OF HUMAN LYMPHOCYTES
    JACK STROMINGER; Fiscal Year: 2001
    ..are: 1) protein chemistry and crystallography of and the relationship of structure to function in class I MHC molecules and their bound peptides, 2) similar studies of class II MHC molecules, 3) the interaction of CD4 with ..
  19. Rejection of Tumors by MHC Class Ib-Restricted CTL
    Eugene Chiang; Fiscal Year: 2005
    Q9, a murine non-polymorphic nonclassical class Ib MHC molecule, has been observed to be downregulated or lost in all Q9-expressing mouse strain-derived tumor cell lines...
  20. CD8 T Cell Reactivity to IGRP as an Autoimmunity Marker in Type 1 Diabetes
    Teresa Dilorenzo; Fiscal Year: 2007
    ..To begin to translate our findings to patients, we used NOD mice transgenic for the human class I MHC molecule HLA-A*0201 to identify HLA-A*0201-binding IGRP peptides targeted by T cells during the spontaneous ..
  21. HLA CLASS I PEPTIDE COMPLEX ADNORMALITIES IN MELANOMA
    Soldano Ferrone; Fiscal Year: 2004
    ..Furthermore, the outlined studies are expected to yield methodology and reagents which will be very useful to screen and monitor patients with malignant diseases to be treated with T cell-based immunotherapy. ..
  22. Robert L Ferris; Fiscal Year: 2014
    ..abstract_text> ..
  23. Antigen processing and HLA-peptide complexes in head and neck cancer
    Soldano Ferrone; Fiscal Year: 2010
    ..abstract_text> ..
  24. Autoimmune Mechanisms in the Response to Renal Cancer
    Julie Ellerhorst; Fiscal Year: 2006
    ..These data will be clinically useful in predicting outcomes of RCC patients, as well as in the understanding of basic mechanisms of host-derived tumor control. ..
  25. HLA Expression in Cancer
    Soldano Ferrone; Fiscal Year: 2006
    ..Soldano Ferrone's expertise in analyzing HLA class I antigen expression by malignant cells and of the reagents he has developed. ..
  26. Organ Culture of Basal Cell Carcinoma
    James Elder; Fiscal Year: 2002
    ....
  27. Amphiregulin in Psoriatic Epidermal Hyperplasia
    JAMES TILFORD ELDER; Fiscal Year: 2010
    ..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..
  28. BIOLOGY OF HUMAN UTERINE NK CELLS
    Ashley Moffett; Fiscal Year: 2004
    ..It could lead to novel therapeutic approaches in a wide range of disorders including infertility, miscarriage, disorders due to defective placentation (pre-eclampsia and IUGR) and menstrual disorders. ..
  29. NK Receptors and Bone Marrow Transplant Outcome
    Katharine Hsu; Fiscal Year: 2008
    ..Dr. Hsu intends to develop a career as an independent investigator in the field of NK cell immunogenetics and allogeneic hematopoietic stem cell transplantation. ..
  30. Spondyloarthritis 2006; The Unmet Needs
    John Reveille; Fiscal Year: 2006
    ..striking familial aggregation and are typically associated with HLA genes of the major histocompatibility complex (MHC), particularly HLA-B27 (1, 2)...
  31. The genetic basis of type 1 diabetes autoimmunity in African Americans
    Janelle Noble; Fiscal Year: 2008
    ..abstract_text> ..
  32. Genetic Epidemiology of Adult Brain Cancer: A Follow-up Study
    Jianming Tang; Fiscal Year: 2008
    ..abstract_text> ..
  33. Liver Disease and HIV-HBV Coinfection in the HAART era
    Chloe Thio; Fiscal Year: 2008
    ..Given the experience of the investigative team and the well-characterized cohorts involved, the results from this proposal will yield insights into the management of HIV-HBV co-infected patients. ..
  34. FAMILY STUDIES OF THE GENETICS OF ANKYLOSING SPONDYLITIS
    John Reveille; Fiscal Year: 2003
    ..have implicated other genes and chromosomal regions, both inside and outside the major histocompatibility complex (MHC), in the pathogenesis of the disorder. The entire MHC contribution has been calculated at only 31 percent...
  35. OPTIMIZING BMT FOR CANCER BY GENETIC MATCHING OF DONORS
    Effie Petersdorf; Fiscal Year: 2003
    ..Because of the fundamental role of MHC class I and related molecules in antigen presentation and T cell recognition, HLA-E and MIC are of immediate ..
  36. MALDI-TOF to Analyze KIR Association with HIV Disease
    Elizabeth Trachtenberg; Fiscal Year: 2006
    ..Data from this study will be critical to future studies examining the functional significance of KIR gene expression in HIV disease. [unreadable] [unreadable]..
  37. SNPs in Lung Cancer Risk and Therapeutic Response
    Effie Petersdorf; Fiscal Year: 2004
    ..abstract_text> ..
  38. Identification of Measles Class II-Restricted Peptides
    INNA OVSYANNIKOVA; Fiscal Year: 2003
    ..The basis from which this proposal will build on is outlined in the background, significance, and preliminary data sections below. ..
  39. DNA Methylation as an Epigenetic Host Factor in HIV/AIDS
    Jianming Tang; Fiscal Year: 2006
    ..abstract_text> ..
  40. Hepatitis B treatment and HIV Infection in resources limited settings
    Chloe L Thio; Fiscal Year: 2010
    ..This proposal has a high likelihood for success given the investigative team's experience, the randomized clinical trial design, and the nesting in an existing study. ..
  41. Immunoglobulin Allotypes in Hepatitis C Virus Infection
    JANARDAN PANDEY; Fiscal Year: 2008
    ..Results of this investigation will advance our understanding of the role of host genetic factors in clearance and persistence of hepatitis C virus infection. ..
  42. Innate Immune Cell Therapy with Stem Cell Transplants
    Sherif Farag; Fiscal Year: 2003
    ..The clinical and laboratory data derived from this trial will form the basis for future phase II studies to investigate the efficacy of this immunotherapy approach. ..
  43. PTLD: cytokine production and gene polymorphisms
    Robert Baiocchi; Fiscal Year: 2005
    ..Our overall goal is to use this data as a springboard for R01 proposals to study the molecular epidemiology of PTLD and to perform prospective therapeutic clinical trials in PTLD patients. ..
  44. Phase I Trial of Herceptin Plus IL12
    William Carson; Fiscal Year: 2003
    ..These studies will provide information on the actions of Herceptin and IL-12, enhance our ability to monitor the effects of antibody-based therapies, and permit the identification of specific markers of responsiveness. ..
  45. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..Cytokine genes are expressed at different levels in older compared to younger women;therefore, we will also evaluate their contribution to breast cancer risk by levels of common exposures such as obesity and HRT use. ..
  46. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
    ..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  47. Enhancing Doctor-Patient Communication
    Stephanie Lee; Fiscal Year: 2006
    ..The project works towards the overall goal of enhancing communication, improving patient understanding, and facilitating psychosocial adaptation to life-threatening illness. ..
  48. HIV Evasion of CTL and NK cells by HLA-G
    Edward Barker; Fiscal Year: 2004
    Major histocompatibility complex (MHC) class I molecules present peptides to T-cell antigen receptors on CD8 T-cells, leading to the activation of the lymphocytes...
  49. GENETIC ANALYSIS OF PSORIASIS
    Anne Bowcock; Fiscal Year: 2001
    ..When alterations are found, they will be screened for in 100 unrelated controls to determine the possibility of their contributing to the development of psoriasis. ..
  50. De Novo Induction of Simian CTL Using Lentivirus Vectors
    Edward Barker; Fiscal Year: 2002
    ..Results from these primate studies will provide important information in developing target vaccines against HIV. ..
  51. Phase 2 Study of Anti Vegf Antibody in Melanoma
    William Carson; Fiscal Year: 2002
    ..Information gained from this trial will help us to understand the mechanism of action of anti-angiogenic drugs and help us to plan future studies in melanoma and other solid tumors. ..
  52. Correlative Studies for Phase II Trial of IL12 and IFNa
    William Carson; Fiscal Year: 2002
    ..This series of experiments will permit us to evaluate the patient response to cytokine therapy at the cellular and molecular levels and identify key determinants of cytokine responsiveness. ..
  53. International Congress of the Immunology of Diabetes Soc
    George Eisenbarth; Fiscal Year: 2002
    ..Travel grants for young investigators will be chosen by numerical rating of submitted abstracts and additional travel funding will be applied to plenary lectures chosen by the international organizing committee. ..
  54. Sequenom MassARTRAY System
    Anne Bowcock; Fiscal Year: 2003
    ..At the end of the grant period it will be incorporated into a core genotyping facility within the Division of Human Genetics. ..
  55. Chlamydia trachomatis and Cervical Cancer
    MARGARET MADELEINE; Fiscal Year: 2003
    ..trachomatis may become a higher public health priority. Furthermore, our results would help determine whether further follow up of the C. trachomatis and cervical cancer association is warranted in a more expensive, prospective setting. ..
  56. Resistance of HIV-infected Cells to Natural Killer Cells
    Edward Barker; Fiscal Year: 2003
    ..This response is especially important since HIV can decrease the expression of major histocompatibility complex (MHC) class I molecules in order to avoid recognition by CD8+ cytotoxic T-lymphocytes...
  57. In vivo testing of the role of TGFb in PTLD
    Anne Vanbuskirk; Fiscal Year: 2003
    ..The results from this pilot study will indicate whether TGFb is crucial to tumor formation in the SCID-Hu PBL mouse model. ..
  58. QMS Technology to Deplete T Cell Alloreactivity
    Sherif Farag; Fiscal Year: 2008
    ..abstract_text> ..
  59. NK Cell Recognition of Leukemia Blasts and IL-2 Therapy
    Sherif Farag; Fiscal Year: 2004
    ..by NK cells is regulated by a balance of activating and inhibitory surface receptors that interact with specific MHC class I and class I-like ligands on target cells...
  60. ACTIVITY OF EXPANDED GAMMA/DELTA T CELLS
    Michael Verneris; Fiscal Year: 2005
    ..Thus, the candidate will acquire the skills to secure a faculty position as a pediatric bone marrow transplantation clinical-scientist...
  61. Model for the Prevention of Post-Transplant Skin Cancer
    Anne Vanbuskirk; Fiscal Year: 2005
    ..This model will provide the pre-clinical basis for new clinical trials in immunosuppressed patients, who are at extremely high risk for developing life-threatening, UV-induced SCC. ..
  62. mTOR Inhibition as a Therapeutic Target in Myeloma
    Sherif Farag; Fiscal Year: 2005
    ..The results of this research have important significance for the treatment of MM and may lead to a novel therapeutic approach in this disease. ..
  63. Genetic Risk Factors for Psoriasis
    Anne Bowcock; Fiscal Year: 2006
    ..Gene identification may be facilitated by the comprehensive gene expression data we have recently acquired in comparing involved and uninvolved psoriatic skin with normal skin. ..
  64. Modulation of Tumor CEA Levels for an Anti-CEA Vaccine
    William Carson; Fiscal Year: 2006
    ..Also, IFN-a upregulates tumor cell expression of MHC class I molecules that are critical for the presentation of tumor antigens to cytolytic T cells...
  65. Therapy of Melanoma with Bortezomib and Interferon-alpha
    William Carson; Fiscal Year: 2007
    ..These studies will help to define the specific apoptotic and immunostimulatory pathways that are being modulated by the combination of bortezomib and IFN-a2b. [unreadable] [unreadable]..
  66. DERMATOLOGY TRAINING GRANT
    Anne Bowcock; Fiscal Year: 2008
    ..We are currently recruiting two tenure-track faculty members and are confident that this will only serve to further strengthen this program, and the quality of scientific opportunities afforded to the trainees. ..