HLA B

Summary

Gene Symbol: HLA B
Description: major histocompatibility complex, class I, B
Alias: B-4901, HLAB, major histocompatibility complex, class I, B, HLA class I antigen HLA-B, HLA class I histocompatibility antigen, B alpha chain, MHC HLA-B cell surface glycoprotein, MHC HLA-B transmembrane glycoprotein, MHC class 1 antigen, MHC class I antigen HLA-B alpha chain, MHC class I antigen HLA-B heavy chain, MHC class I antigen SHCHA, MHC class I molecule, leukocyte antigen class I-B
Species: human

Top Publications

  1. pmc Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    Nat Genet 42:698-702. 2010
  2. doi Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population
    Wichittra Tassaneeyakul
    Departments of Pharmacology, Khon Kaen University, Khon Kaen, Thailand
    Pharmacogenet Genomics 19:704-9. 2009
  3. ncbi Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan
    Allan Hildesheim
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 7062, Rockville, MD 20852, USA
    J Natl Cancer Inst 94:1780-9. 2002
  4. ncbi HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais
    H A F Stephens
    Institute of Urology and Nephrology, University College, London, UK
    Tissue Antigens 60:309-18. 2002
  5. ncbi The detailed distribution of HLA-A, B, C antigens in normal human organs
    A S Daar
    Transplantation 38:287-92. 1984
  6. ncbi Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses
    Anke Specht
    Institute of Virology, Universitatsklinikum, 89081 Ulm, Germany
    Virology 373:229-37. 2008
  7. doi Role of HIV-1 Nef protein for virus replication in vitro
    Abhay Jere
    Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Microbes Infect 12:65-70. 2010
  8. ncbi Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population
    A Lopez-Vazquez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Hum Immunol 66:285-9. 2005
  9. pmc HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:140-9. 2009
  10. pmc The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    Florencia Pereyra
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
    Science 330:1551-7. 2010

Research Grants

  1. Malini Raghavan; Fiscal Year: 2016
  2. GENETICS OF INSULIN-DEPENDENT DIABETES MELLITUS
    CHESTER ALPER; Fiscal Year: 1991
  3. Philip J Goulder; Fiscal Year: 2014
  4. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
  5. Combination immunotherapy with gene modified CD4 and CD8 T cells and stem cells
    Carl H June; Fiscal Year: 2013
  6. Innate Effector Function and HIV-1 Control
    Luis J Montaner; Fiscal Year: 2010
  7. David A Ostrov; Fiscal Year: 2016
  8. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    Jianming Tang; Fiscal Year: 2012
  9. DEVELOPMENT OF HLA-B7 SUPERTYPE-BINDING HIV CTL VACCINES
    David Lee; Fiscal Year: 1999
  10. High-Throughput HLA-Typing: on Raw, Unpurified Cord Blood Samples
    Michael E Hogan; Fiscal Year: 2013

Detail Information

Publications375 found, 100 shown here

  1. pmc Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    Nat Genet 42:698-702. 2010
    ..34-1.58) and the IL23R-IL12RB2 locus (rs924080, P = 6.69 x 10(-9), OR = 1.28, 95% CI 1.18-1.39). The disease-associated IL10 variant (the rs1518111 A allele) was associated with diminished mRNA expression and low protein production...
  2. doi Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population
    Wichittra Tassaneeyakul
    Departments of Pharmacology, Khon Kaen University, Khon Kaen, Thailand
    Pharmacogenet Genomics 19:704-9. 2009
    ..e. European and Japanese). This study investigated the relationship between SJS/TEN and HLA-B*5801 in a Thai population that has a high allelic frequency of this allele...
  3. ncbi Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan
    Allan Hildesheim
    Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rm 7062, Rockville, MD 20852, USA
    J Natl Cancer Inst 94:1780-9. 2002
    ..We used high-resolution HLA genotyping in a case-control study in Taiwan to systematically evaluate the association between various HLA alleles and NPC...
  4. ncbi HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais
    H A F Stephens
    Institute of Urology and Nephrology, University College, London, UK
    Tissue Antigens 60:309-18. 2002
    ..These results confirm that classical HLA class I alleles are associated with the clinical outcome of exposure to dengue virus, in previously exposed and immunologically primed individuals...
  5. ncbi The detailed distribution of HLA-A, B, C antigens in normal human organs
    A S Daar
    Transplantation 38:287-92. 1984
    ..We conclude, therefore, that class I antigens are not ubiquitous, as previously thought...
  6. ncbi Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses
    Anke Specht
    Institute of Virology, Universitatsklinikum, 89081 Ulm, Germany
    Virology 373:229-37. 2008
    ....
  7. doi Role of HIV-1 Nef protein for virus replication in vitro
    Abhay Jere
    Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Microbes Infect 12:65-70. 2010
    ..This review summarizes and organizes current knowledge of HIV-1 Nef with respect to this particularly virological activity for understanding the basis of its in vivo function...
  8. ncbi Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population
    A Lopez-Vazquez
    Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain
    Hum Immunol 66:285-9. 2005
    ..00003; OR = 10.11). The presence of the inhibitory allele KIR3DL1 in combination with the HLA-B*57s alleles that contain the Bw4-I80 epitope, has a highly protective effect against progression to AIDS in Zambian patients...
  9. pmc HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1
    Toshiyuki Miura
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Room 5212, Charlestown, MA 02129, USA
    J Virol 83:140-9. 2009
    ....
  10. pmc The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    Florencia Pereyra
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology MIT and Harvard, Boston, MA, USA
    Science 330:1551-7. 2010
    ..These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection...
  11. pmc Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B
    Julian P Vivian
    Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Nature 479:401-5. 2011
    ....
  12. ncbi High-resolution HLA alleles and haplotypes in the United States population
    Martin Maiers
    National Marrow Donor Program, Minneapolis, Minnesota, USA
    Hum Immunol 68:779-88. 2007
    ..The electronic availability of this information will be useful for projects central to the typing and use of population data in HLA applications...
  13. pmc CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression
    Nicoletta Casartelli
    Division of Immunology and Infectious Disease, Children s Hospital Bambino Gesu, Rome, Italy
    J Virol 77:11536-45. 2003
    ..Our data indicate that Nef-mediated downregulation of cell surface CD4 and MHC-I significantly contributes to the expression of the pathogenic potential of HIV-1...
  14. ncbi Genetic link between Chaoshan and other Chinese Han populations: Evidence from HLA-A and HLA-B allele frequency distribution
    Sheng Ping Hu
    Center for Molecular Biology and Forensic Genetics Laboratory, Shantou University Medical College, Shantou, Guangdong 515031, People s Republic of China
    Am J Phys Anthropol 132:140-50. 2007
    ..The different genetic background between northern and southern China may explain, at least partially, the prevalence of NPC among southern Chinese...
  15. ncbi Amino acid 95 causes strong alteration of peptide position Pomega in HLA-B*41 variants
    Christina Bade-Doeding
    Institute for Transfusion Medicine, Hanover Medical School, Hanover, Germany
    Immunogenetics 59:253-9. 2007
    ....
  16. pmc HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements
    Jolie A Leonard
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA
    J Virol 85:6867-81. 2011
    ..These studies provide important new information on the similarities and differences with which Nef affects intracellular trafficking and help focus future research on the best potential pharmaceutical targets...
  17. doi Association of ARTS1 gene polymorphisms with ankylosing spondylitis in the Hungarian population: the rs27044 variant is associated with HLA-B*2705 subtype in Hungarian patients with ankylosing spondylitis
    Borbála Pazár
    National Institute of Rheumatology and Physiotherapy, Budapest, Hungary
    J Rheumatol 37:379-84. 2010
    ..We studied the association of 5 polymorphisms within the ARTS1 gene with AS in Hungarian patients. We also investigated the prevalence of HLA-B27 subtypes in the Hungarian population...
  18. doi Distribution of CCR5 genotypes and HLA Class I B alleles in HIV-1 infected and uninfected injecting drug users from Rio de Janeiro, Brazil
    Sylvia Lopes Maia Teixeira
    Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation FIOCRUZ, Rio de Janeiro, Brazil
    Infect Genet Evol 9:638-42. 2009
    ....
  19. doi High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients
    Gbenga R Kazeem
    GlaxoSmithKline, Harlow, UK
    Pharmacogenet Genomics 19:661-5. 2009
    ..Severe cutaneous adverse reactions (SCARs) are associated with over 200 medicines including lamotrigine, an antiepileptic drug. Previous studies have suggested the involvement of immune mechanisms in the development of drug-induced SCARs...
  20. ncbi Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level
    Corey B Moore
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, WA 6000, Australia
    Science 296:1439-43. 2002
    ..At a population level, the degree of HLA-associated selection in viral sequence was predictive of viral load. These results support a fundamental role for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo...
  21. doi A combined genotype of KIR3DL1 high expressing alleles and HLA-B*57 is associated with a reduced risk of HIV infection
    Salix Boulet
    Research Institute of the McGill University Health Centre, Canada
    AIDS 22:1487-91. 2008
    ..We questioned whether this allele combination could also influence resistance to infection...
  22. ncbi HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in the Kinh population in Vietnam
    B K Hoa
    Faculty of Hematology and Blood Transfusion, Hanoi Medical School, Hanoi, Vietnam
    Tissue Antigens 71:127-34. 2008
    ..Allele distribution and haplotype analysis demonstrated that the Vietnamese population shares HLA patterns with southern Chinese, Thai, Javanese and Micronesians, while it also retains unique characteristics...
  23. doi HLA-B*5701 screening for hypersensitivity to abacavir
    Simon Mallal
    Royal Perth Hospital and Murdoch University, Perth, Australia
    N Engl J Med 358:568-79. 2008
    ..This study was designed to establish the effectiveness of prospective HLA-B*5701 screening to prevent the hypersensitivity reaction to abacavir...
  24. ncbi An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501
    K J Smith
    Nuffield Department of Clinical Medicine, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Immunity 4:203-13. 1996
    The crystal structure of the human major histocompatibility complex class I B allele HLA B*3501 complexed with the 8-mer peptide epitope HIV1 Nef 75-82 (VPLRPMTY) has been determined at 2.0 angstrom resolution...
  25. pmc HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load
    Christine M Rousseau
    Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 82:6434-46. 2008
    ....
  26. pmc HLA-A, -B, -C, and -DRB1 allele and haplotype frequencies distinguish Eastern European Americans from the general European American population
    S J Mack
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Tissue Antigens 73:17-32. 2009
    ....
  27. doi HLA alleles and haplotypes distribution in Dai population in Yunnan province, Southwest China
    L Shi
    Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China
    Tissue Antigens 75:159-65. 2010
    ..Our results showed that the Dai population has unique HLA characteristic that are most closely related to the Southeastern Asia group and similar to the Kam-Tai speaking populations in China and Thailand...
  28. pmc HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Diabetes 59:2972-9. 2010
    ..We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study...
  29. pmc The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes
    E E Baschal
    Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA
    Diabetes Obes Metab 11:25-30. 2009
    ....
  30. pmc TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais
    Sasijit Vejbaesya
    Department of Transfusion Medicine, Siriraj Hospital and Medical School, Mahidol University, Bangkok, Thailand
    J Infect Dis 199:1442-8. 2009
    ..These observations indicate that polymorphism in functionally distinct MHC-encoded proteins contributes to the risk of developing severe secondary DENV infection and warrants further investigation...
  31. ncbi MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studies
    M Malkki
    The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Tissue Antigens 66:114-24. 2005
    ..Markers with high HSH values will be most informative in studies investigating MHC region disease-susceptibility genes where HLA haplotypic effects are known to exist...
  32. pmc HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection
    Karen A McAulay
    Clinical and Basic Virology Laboratory, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Summerhall, Edinburgh, United Kingdom
    J Clin Invest 117:3042-8. 2007
    ....
  33. pmc Impaired cell surface expression of HLA-B antigens on mesenchymal stem cells and muscle cell progenitors
    Adiba Isa
    Center for Stem Cell Treatment, Department of Clinical Immunology, Odense University Hospital, University of Southern Denmark, Odense, Denmark
    PLoS ONE 5:e10900. 2010
    ....
  34. pmc The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    M E Greenberg
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    EMBO J 17:2777-89. 1998
    ....
  35. pmc HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    Shuen Iu Hung
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
    Proc Natl Acad Sci U S A 102:4134-9. 2005
    ..Our results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese. In particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition...
  36. ncbi Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population
    S Saito
    Nagano Red Cross Blood Center, Nagano, Japan
    Tissue Antigens 56:522-9. 2000
    ....
  37. ncbi Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57
    Geraldine M A Gillespie
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    AIDS 16:961-72. 2002
    ....
  38. pmc Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis
    Paul Bowness
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Immunol 186:2672-80. 2011
    ..Our findings link HLA-B27 with IL-17 production and suggest new therapeutic strategies in ankylosing spondylitis/SpA...
  39. ncbi Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
    O Schwartz
    Laboratoire Rétrovirus et Transfert Génétique, Unité de Recherche Associée CNRS 1157, Paris, France
    Nat Med 2:338-42. 1996
    ..The stimulation of MHC-I endocytosis by Nef represents a previously undocumented viral mechanism for evading the immune response...
  40. pmc HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
    V Piguet
    Department of Genetics and Microbiology, Faculty of Medicine, University of Geneva, Geneva 1211, Switzerland
    Nat Cell Biol 2:163-7. 2000
    ..These results support a model in which Nef relocalizes MHC-I by acting as a connector between MHC-I's cytoplasmic tail and the PACS-1-dependent protein-sorting pathway...
  41. ncbi Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort
    Shu Li
    Vaccine Laboratory, Nankai University, Tianjin, China
    J Acquir Immune Defic Syndr 44:121-31. 2007
    ..These data contribute to the database of allele frequencies and associations with HIV infection in the Chinese population...
  42. pmc HLA genotyping in the international Type 1 Diabetes Genetics Consortium
    Josyf C Mychaleckyj
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    Clin Trials 7:S75-87. 2010
    ....
  43. ncbi Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression
    Guillaume B E Stewart-Jones
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Immunol 175:2459-68. 2005
    ....
  44. doi HLA class I markers in Japanese patients with carbamazepine-induced cutaneous adverse reactions
    Hiroko Ikeda
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 51:297-300. 2010
    ..These data may suggest that HLA-B*5901 is one of the candidate markers for CBZ-induced SJS in Japanese...
  45. ncbi Diversity and diversification of HLA-A,B,C alleles
    P Parham
    Department of Cell Biology, Stanford University, CA 94305
    J Immunol 142:3937-50. 1989
    ..Although greater diversity is seen in the 5' "variable" exons of HLA-B compared to HLA-A, there is increased heterogeneity in the 3' "conserved" exons of HLA-A compared to HLA-B...
  46. ncbi HLA class I and class II allele and haplotype diversity in Martinicans
    O Bera
    Laboratoire de Virologie Immunologie, CHU de Fort de France, Martinique
    Tissue Antigens 57:200-7. 2001
    ....
  47. ncbi HLA associations with nasopharyngeal carcinoma in Southern Chinese: a meta-analysis
    D B Goldsmith
    Department of Otolaryngology, Green Lane Hospital, Auckland, New Zealand
    Clin Otolaryngol Allied Sci 27:61-7. 2002
    ..There is evidence that specific allele subtypes or combinations of alleles may carry particular risk for NPC...
  48. ncbi Association of ankylosing spondylitis with HLA-B*1403 in a West African population
    Carlos Lopez-Larrea
    Department of Immunology, Hospital Central de Asturias, Julian Claveria, Oviedo 33006, Spain
    Arthritis Rheum 46:2968-71. 2002
    ..To investigate the contribution of HLA class I alleles in the susceptibility to primary ankylosing spondylitis (AS) in West African patients living in Togo...
  49. ncbi HLA class I allele distribution of a Hong Kong Chinese population based on high-resolution PCR-SSOP typing
    D Middleton
    Northern Ireland Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, UK
    Tissue Antigens 63:555-61. 2004
    ..In addition, knowing which alleles do/do not occur in this population will aid in the distinction of ambiguities which result from the use of many of the typing kits available...
  50. ncbi Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population
    M L Feng
    Shanghai Institute of Blood Transfusion, Shanghai Blood Center, Shanghai, China
    Tissue Antigens 64:281-5. 2004
    ....
  51. ncbi The contribution of HLA class I antigens in immune status following two doses of rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Hum Immunol 65:1506-15. 2004
    ..These data may facilitate our understanding of immune response variation in a genetically outbred heterogeneous population...
  52. ncbi HLA-A, HLA-B, and HLA-DRB1 alleles and haplotypes in Naxi and Han populations in southwestern China (Yunnan province)
    L Shi
    Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, China
    Tissue Antigens 67:38-44. 2006
    ....
  53. pmc HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control
    Brinda Emu
    Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    J Virol 82:5398-407. 2008
    ..Defining mechanisms for virus control in "non-T-cell controllers" might lead to insights into preventing HIV transmission or preventing virus replication...
  54. ncbi Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients
    Hsien Tzung Liao
    Taipei Medical University, Municipal Wan Fang Hospital, Hualien, Taiwan
    J Rheumatol 35:891-5. 2008
    ..We conducted a retrospective study to determine the human leukocyte antigen (HLA) -A, -B, -Cw, -DR, and -DQ alleles in Chinese patients with PsA and psoriasis...
  55. doi The interplay between the geographic distribution of HLA-B27 alleles and their role in infectious and autoimmune diseases: a unifying hypothesis
    Alessandro Mathieu
    Department of Medical Sciences, University of Cagliari, University Clinic, Monserrato Cagliari, Italy
    Autoimmun Rev 8:420-5. 2009
    ....
  56. ncbi The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC
    D R Madden
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Cell 70:1035-48. 1992
    ..The concentration of binding interactions at the peptide termini permits extensive sequence (and probably some length) variability in the center of the peptide, where it is exposed for T cell recognition...
  57. ncbi Both HLA-B*1301 and B*1302 exist in Asian populations and are associated with different haplotypes
    L Lin
    Japanese Red Cross Central Blood Center, Tokyo
    Hum Immunol 43:51-6. 1995
    ..In addition, applying the PCR-SSCP method, B*1301 and B*1302 could also be simply distinguished from each other...
  58. ncbi Differences in intron 2 sequences between B*39061 and B*39062 in Amerindians: comparison with those of B*3901, B*5101, and B*52012 alleles
    G Vargas-Alarcon
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera de Andalucia, 28041 Madrid, Spain
    Immunogenetics 45:436-9. 1997
  59. ncbi Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Immunol 160:3096-100. 1998
    ..ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity...
  60. ncbi Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules
    S Le Gall
    Laboratoire Rétrovirus et Transfert Génétique Unité de Recherche Associée CNRS 1157, Institut Pasteur, Paris, France
    Immunity 8:483-95. 1998
    ..Nef interacts with the medium (mu) subunit of AP adaptor complexes involved in the recognition of tyrosine-based sorting signals, likely facilitating the connection between MHC I and the clathrin-dependent sorting machinery...
  61. ncbi The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC
    N L Riggs
    Department of Medicine, University of California, San Diego, CA, USA
    Virology 258:203-7. 1999
    ..The data also suggest that protein interactions mediated by the acidic domain, rather than by the dileucine motif, may contribute to this function of Nef...
  62. ncbi HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations
    D Modiano
    Istituto di Parassitologia, W H O Collaborating Centre for Malaria Epidemiology, Universita di Roma La Sapienza, Rome, Italy
    Tissue Antigens 57:128-37. 2001
    ..555). Our study does not suggest the involvement of HLA I in the higher resistance to malaria of Fulani, and confirms a low, if any, Caucasoid component in their gene pool...
  63. ncbi Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS
    X Gao
    Intramural Research Support Program, Science Applications International Corporation Frederick and the National Cancer Institute, MD, USA
    N Engl J Med 344:1668-75. 2001
    ..We examined subtypes of HLA-B*35 in five cohorts and analyzed the relation of structural differences between HLA-B*35 subtypes to the risk of progression to AIDS...
  64. ncbi Association between HLA-A/-B antigens and -DRB1 alleles and nasopharyngeal carcinoma in Tunisia
    N Mokni-Baizig
    Institut de Carcinologie Salah Azaiz, Tunis, Tunisie
    Oncology 61:55-8. 2001
    ..5 vs. 14%) suggesting a protective effect of this association with NPC...
  65. pmc Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits
    Antony N Antoniou
    Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Dundee, UK
    Immunology 106:182-9. 2002
    ..Together these data indicate that single TAP polypeptide subunits possess many of the features of the TAP heterodimer, demonstrating them to be useful models in the study of ATP-binding cassette (ABC) transporters...
  66. ncbi Analysis of microsatellite polymorphism around the HLA-B locus in Iranian patients with Behçet's disease
    N Mizuki
    Department of Ophthalmology, Yokohama City University School of Medicine, Kanagawa, Japan
    Tissue Antigens 60:396-9. 2002
    ..Therefore, HLA-B51 was confirmed to be by far the most strongly associated gene with BD in an Iranian population...
  67. pmc Proline 78 is crucial for human immunodeficiency virus type 1 Nef to down-regulate class I human leukocyte antigen
    Takeshi Yamada
    Division of Infectious Diseases, Advanced Clinical Research Center, The University of Tokyo, Japan
    J Virol 77:1589-94. 2003
    ..Analyses of a series of PRD substitution mutants indicated that, because the substitution of Pro78 with Ala abolished down-regulation of HLA-I but not of CD4, Pro78 is important for HLA-I down-regulation in T lymphocytes...
  68. pmc Human leukocyte antigen (HLA) B*18 and protection against mother-to-child HIV type 1 transmission
    Carey Farquhar
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS Res Hum Retroviruses 20:692-7. 2004
    ..Among 433 infants, 76 (18%) were HIV-1 infected during 12 months of follow-up. HLA B*18 was associated with a significantly lower risk of early HIV-1 transmission [relative risk (RR) = 0...
  69. ncbi HLA-B27 genotyping by fluorescent resonance emission transfer (FRET) probes in real-time PCR
    Rosa Faner
    Laboratory of Immunobiology Research and Applications to Diagnosis LIRAD, Serveis Sanitaris de Referència Centre de Transfusió i Banc de Teixits SSR CTBT, Badalona, Barcelona, Spain
    Hum Immunol 65:826-38. 2004
    ..There was a complete concordance rate, thus confirming the potential of this new technique for clinical HLA-B27 typing and for HLA typing in general...
  70. ncbi Human leucocyte antigen determinants of susceptibility to Barrett's oesophagus in Asians--a preliminary study
    S Rajendra
    Division of Gastroenterology, Department of Medicine, Royal Perak College of Medicine, Ipoh, Malaysia
    Aliment Pharmacol Ther 21:1377-83. 2005
    ..Characteristic immune profiles have been demonstrated in gastro-oesophageal reflux disease. However, the genetic basis of gastro-oesophageal reflux disease remains unclear...
  71. ncbi HLA class I and II polymorphisms in Azores show different settlements in Oriental and Central islands
    H Spinola
    Human Genetics Laboratory, University of Madeira, Funchal, Portugal
    Tissue Antigens 66:217-30. 2005
    ..The Central group of islands on the contrary clearly shows an influence of north Europeans (most probably derived from a well-documented Flemish settlement), with much less affinity to mainland Portugal...
  72. ncbi [Gene and haplotype frequencies for the loci HLA-A, B and DRB1 in 11755 north Chinese Han bone marrow registry donors]
    Qiang Ju Wu
    Blood Center of Shanxi Province, Xi an 710061, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:357-63. 2007
    ..The study will be helpful to find matched donors for patients and establish the important foundation for further studying of transplantation immunity, HLA-related diseases and population genetics of this area...
  73. pmc HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2
    Nienke B Lubben
    University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom
    Mol Biol Cell 18:3351-65. 2007
    ..We propose that depleting AP-2 potentiates Nef activity by altering the membrane composition and dynamics of endosomes and causing increased delivery of HLA-A2 to a prelysosomal compartment...
  74. pmc Selective pressures of HLA genotypes and antiviral therapy on human immunodeficiency virus type 1 sequence mutation at a population level
    Golo Ahlenstiel
    Department of Internal Medicine I, University of Bonn, 53105 Bonn, Germany
    Clin Vaccine Immunol 14:1266-73. 2007
    ..As several of the HLA-associated mutations lie at positions associated with drug resistance, our results indicate possible negative effects of HLA genotypes on the development of HIV-1 drug resistance...
  75. ncbi High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation
    Stephanie J Lee
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 110:4576-83. 2007
    ..High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of survival...
  76. ncbi The polymorphism and haplotype analysis of HLA-A, -B and -DRB1 genes of population in Jiangsu province of China
    K R Miao
    HLA Laboratory, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
    Int J Immunogenet 34:419-24. 2007
    ..These findings could shade new lights in population genetics and anthropology studies of Han-Chinese...
  77. pmc Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage
    Denis R Chopera
    Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS Pathog 4:e1000033. 2008
    ....
  78. doi Role of Nef in primate lentiviral immunopathogenesis
    F Kirchhoff
    Institute of Virology, University of Ulm, 89081 Ulm, Germany
    Cell Mol Life Sci 65:2621-36. 2008
    ..This evolutionary loss of a specific Nef function may contribute to the high virulence of HIV-1 in humans...
  79. pmc Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain
    Laura L Baugh
    Y9 206, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Virol 82:9657-67. 2008
    ..Our results are consistent with an alternative model in which (62)EEEE(65) plays a stabilizing role in the formation of a ternary complex between Nef, the MHC-I cytoplasmic domain, and AP-1...
  80. doi Disparate folding and stability of the ankylosing spondylitis-associated HLA-B*1403 and B*2705 proteins
    Elena Merino
    Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Universidad Autonoma, Madrid, Spain
    Arthritis Rheum 58:3693-704. 2008
    ....
  81. doi Polymorphisms of HLA genes in Western Javanese (Indonesia): close affinities to Southeast Asian populations
    R Yuliwulandari
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Tissue Antigens 73:46-53. 2009
    ....
  82. pmc HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3349-58. 2009
    ....
  83. pmc Adaptation of HIV-1 to human leukocyte antigen class I
    Yuka Kawashima
    Division of Viral Immunology, Center for AIDS Research, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Nature 458:641-5. 2009
    ....
  84. doi Class I HLA folding and antigen presentation in beta 2-microglobulin-defective Daudi cells
    Aline Martayan
    Laboratory of Immunology, Regina Elena Cancer Institute Centro della Ricerca Sperimentale, Rome, Italy
    J Immunol 182:3609-17. 2009
    ..These findings bear potential implications for tumor immunotherapy...
  85. pmc HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats
    Monica L DeLay
    Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, Cincinnati, Ohio
    Arthritis Rheum 60:2633-43. 2009
    ....
  86. pmc Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes
    Kati Lipponen
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Diabetes 59:3253-6. 2010
    ..To test this hypothesis we analyzed the role of HLA class I and class II gene polymorphisms in the progression from diabetes-associated autoimmunity to clinical disease...
  87. pmc Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection
    Mark A Brockman
    Simon Fraser University, Molecular Biology and Biochemistry, British Columbia V5A 1S6, Canada
    J Virol 84:11937-49. 2010
    ..The long-term control of HIV-1 in some persons who express protective alleles suggests that early fitness hits may provide lasting benefits...
  88. pmc Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
    David M Evans
    Medical Research Council MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Nat Genet 43:761-7. 2011
    ..These findings provide strong evidence that HLA-B27 operates in ankylosing spondylitis through a mechanism involving aberrant processing of antigenic peptides...
  89. pmc Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function
    Pieter J Meuwissen
    Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University, Ghent, B 9000, Belgium
    Retrovirology 9:34. 2012
    ..In this study, we aimed to study the functional importance of this VGF region...
  90. pmc Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix
    Lillian S Kuo
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y9 206, Dallas, TX 75390, USA
    Retrovirology 9:47. 2012
    ..Further, mutation of the non-motif "X" residues, (Q73, V74, and L75) would give altered patterns of inhibition for different Nef/SH3 domain protein interactions...
  91. pmc Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef
    Xiaofei Jia
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA
    Nat Struct Mol Biol 19:701-6. 2012
    ..The structure shows how Nef functions as a clathrin-associated sorting protein to alter the specificity of host membrane trafficking and enable viral evasion of adaptive immunity...
  92. pmc HIV protective KIR3DL1/S1-HLA-B genotypes influence NK cell-mediated inhibition of HIV replication in autologous CD4 targets
    Rujun Song
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    PLoS Pathog 10:e1003867. 2014
    ..We conclude that NK-mediated inhibition of viral replication in autologous iCD4 cells is partially due to a block at the level of HIV entry into new targets by secreted CC-chemokines. ..
  93. pmc Differential escape patterns within the dominant HLA-B*57:03-restricted HIV Gag epitope reflect distinct clade-specific functional constraints
    R P Payne
    Department of Paediatrics, University of Oxford, Oxford, United Kingdom
    J Virol 88:4668-78. 2014
    ..Further studies are needed to evaluate the role of the KF11 response in HLA-B*57:01-associated HIV disease protection...
  94. ncbi Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B
    S Nejentsev
    Juvenile Diabetes Foundation Center for Type 1 Diabetes Prevention in Finland, Turku
    Diabetes 49:2217-21. 2000
    ..Our data indicate that an additional gene associated with type 1 diabetes is located in the 240-kb region near HLA-B. We excluded STR MICA polymorphism as a mutation responsible for diabetes association...
  95. ncbi HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway
    S A Swann
    Departments of Medicine and Microbiology and Immunology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Virology 282:267-77. 2001
    ..We propose that Nef diverts MHC-1 proteins into a PI 3-kinase-dependent transport pathway that prevents expression on the cell surface...
  96. pmc Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines
    R A Kaslow
    Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Virol 75:8681-9. 2001
    ..This proof of principle that class I an alleles modulate both processes has implications for development of HIV-1 and presumably other vaccines...
  97. ncbi Disparate binding of chaperone proteins by HLA-A subtypes
    Heth R Turnquist
    Eppley Institute for Research in Cancer and Allied Diseases, Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805 USA
    Immunogenetics 53:830-4. 2002
    ..In total, HLA-A molecules exhibit natural allele-specific distinctions in chaperone association that correlate with differences in cell surface expression and with the identity of amino acid position 116...
  98. pmc HLA-A and -B alleles and haplotypes in hemochromatosis probands with HFE C282Y homozygosity in central Alabama
    James C Barton
    Southern Iron Disorders Center, Birmingham, Alabama, USA
    BMC Med Genet 3:9. 2002
    ..We wanted to quantify HLA-A and -B allele and haplotype frequencies in Alabama hemochromatosis probands with HFE C282Y homozygosity and controls, and to compare results to those in other populations...
  99. ncbi MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypes
    Emilio G De la Concha
    Department of Immunology, Hospital Clinico San Carlos, La Paz Hospital, 28040 Madrid, Spain
    J Immunol 169:4637-43. 2002
    ....
  100. ncbi Genetic susceptibility to nasopharyngeal carcinoma within the HLA-A locus in Taiwanese
    Cheng Chan Lu
    Department of Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    Int J Cancer 103:745-51. 2003
    ..Allele 4 of D6S211 was significantly associated with NPC (OR = 3.97, pc = 0.0042). These results strongly support the hypothesis that genes associated with susceptibility to NPC in the HLA region are within the HLA-A locus...

Research Grants72

  1. Malini Raghavan; Fiscal Year: 2016
    ....
  2. GENETICS OF INSULIN-DEPENDENT DIABETES MELLITUS
    CHESTER ALPER; Fiscal Year: 1991
    ..Finally, the transmission of extended haplotypes from mothers and fathers will be analyzed in all study families to identify haplotypes with segregation distortion (possible human analogs of mouse t- mutants)...
  3. Philip J Goulder; Fiscal Year: 2014
    ..How fast, and the extent to which, these escape mutants accumulate will be considered in these proposed studioes, to determine whether viral adaptation in fact is likely to have an impact on current T-cell vaccine design. ..
  4. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    ..By studying these rapidly evolving immune system components in closely related species of non-human primate we will gain new insight and greater understanding of the human system and its contribution to human health and survival. ..
  5. Combination immunotherapy with gene modified CD4 and CD8 T cells and stem cells
    Carl H June; Fiscal Year: 2013
    ....
  6. Innate Effector Function and HIV-1 Control
    Luis J Montaner; Fiscal Year: 2010
    ....
  7. David A Ostrov; Fiscal Year: 2016
    ..assays, MHC ligand elution and X- ray crystallography, we have shown that abacavir binds inside the F-pocket of HLA B*57:01, thereby altering its specificity...
  8. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    Jianming Tang; Fiscal Year: 2012
    ....
  9. DEVELOPMENT OF HLA-B7 SUPERTYPE-BINDING HIV CTL VACCINES
    David Lee; Fiscal Year: 1999
    ..The HLA B-7 supertype covers approximately 49% of the population, and those alleles tend to bind identical viral peptide ..
  10. High-Throughput HLA-Typing: on Raw, Unpurified Cord Blood Samples
    Michael E Hogan; Fiscal Year: 2013
    ..That "Raw Guthrie Card" HLA-Typing would then be compared, in terms of accuracy &cost, to that obtained by current methods of HLA-Typing on purified DNA. ..
  11. IDENTIFICATION OF HLA MRNA REGULATORY ELEMENTS
    JANE MCCUTCHEON; Fiscal Year: 2000
    ..These studies will increase our understanding of immune regulation. ..
  12. Protective roles of CTL responses to HIV-1 associated self epitope
    BETH DEIRDRE JAMIESON KARAVODIN; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The experiments could benefit HIV-1 infected individuals by providing a unique avenue for the development of therapeutic strategies. ..
  13. CD8 T Cell Reactivity to IGRP as an Autoimmunity Marker in Type 1 Diabetes
    Teresa Dilorenzo; Fiscal Year: 2007
    ..Tests may also be developed to monitor destructive T cell activity in patients undergoing treatment, so that doctors will be able to know if the treatments are working. [unreadable] [unreadable] [unreadable]..
  14. Molecular Genetics of BAT Genes and SLE Risk
    F Yesim Demirci; Fiscal Year: 2013
    ..The study results are likely to provide useful insights into SLE-related pathologic mechanisms and may also shed light on other MHC-linked autoimmune diseases with overlapping pathology. ..
  15. Multifactorial Genetic Disease Model:Schizophrenial/HLA
    Wendie Robbins; Fiscal Year: 2003
    ..The candidate lacks the training necessary for research at the gene or gene and gene/environment interaction level. Schizophrenia (as an example of a complex genetic disorder) will provide an excellent model for training. ..
  16. HLA*B Associated Genes and Memory B cells in patients with CVID
    Harry Schroeder; Fiscal Year: 2009
    ....
  17. INVESTIGATION Of HUMAN COMPLEMENT
    CHESTER ALPER; Fiscal Year: 1999
    ..Finally, we plan to try to explain the evolution and genetic mechanisms of origin of haplotypes with the relatively rare variant of the second component of complement, C2 B. ..
  18. Identification of Psoriatic Arthritis Genes
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..Its cause is not well understood. Identification of genes that increase risk of psoriatic arthritis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..
  19. Discovery and Assessment of Genetic Determinants of HCV and HIV Control
    Arthur Y Kim; Fiscal Year: 2010
    ..Using powerful genomic tools, we will comprehensively identify additional genes and decipher the means by which they produce improved clearance of these debilitating infections. ..
  20. AIDS-Restrictive Innate Immune Mechanisms
    William H Carr; Fiscal Year: 2011
    ..This plan is well suited for Dr. Carr to establish long-term scientific collaborations in South Africa and to establish himself as an independent investigator in international health research ..
  21. A Low Cost Microarray for Population-Scale AIDS Risk Analysis: The AIDS Chip
    Michael E Hogan; Fiscal Year: 2010
    ..However, we are equally certain that, whatever those new population scale genetic tools may be, the way that they are used, will look very much like the "Guthrie Card + AIDS-Chip" pairing of this SBIR. ..
  22. Mapping novel subdominant B*5701 epitopes in conserved regions of the HIV proteom
    June Kan-Mitchell; Fiscal Year: 2011
    ..We expect to learn more about how responding T cells contribute to HIV control and will evaluate an ex vivo human vaccination model that may help advance future vaccine candidates to clinical testing. ..
  23. Vijay K Kuchroo; Fiscal Year: 2016
    ..The proposed studies will identify the molecular mechanisms by which Tim-3 mediates its inhibitory function, which could be exploited to dampen pathogenic T cells in autoimmune diseases. ..
  24. David I Watkins; Fiscal Year: 2016
    ..Mamu-B*17 positive macaques, an animal model of spontaneous control of AIDS virus replication with similarities to HLAB* 57 positive human ECs...
  25. B27 BINDING BACTERIAL AND SELF PEPTIDES IN B27 ARTHRITIS
    R Scofield; Fiscal Year: 2000
    ....
  26. Richard Sutton; Fiscal Year: 2016
    ..In the end I hope to have identified genetic factors responsible for host control of HIV. ..
  27. Genotyping assays for the most common mutations associated with abacavir hypersen
    BERTRAND LEMIEUX; Fiscal Year: 2009
    ..e., HLA B*5701 and the Hsp70-Hom M493T allele (a.k.a. rs2227956CT)...
  28. Thomas Pertel; Fiscal Year: 2014
    ..While boosting Tim-3 signals could dampen autoimmune disease, repressing Tim-3 function could augment immune responses in chronic viral infections (e.g. HIV) and cancer. ..
  29. Prior Antigenic Exposure and HIV Disease Progression
    Beth Jamieson; Fiscal Year: 2005
    ..We have unique specimens from HLA-B*57+ individuals taken both prior to, and early after, HIV infection to that we will use to test our hypothesis. ..
  30. MAMDC--UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE
    David Glass; Fiscal Year: 2000
    ..H. Giannini, MSc, DrPH 2) Molecular Genotyping and Sequencing; -S.D. Thompson, PhD Establishment of the MAMDC will promote innovative approaches to laboratory an clinical research. ..
  31. ENDOGENOUSLY REGULATED IMMUNOMODULATION
    Robert Munford; Fiscal Year: 2003
    ..Potential disease targets include chronic arthritis (rheumatoid, Lyme, reactive [HLA B-27 related, microbially induced], other), organ transplant rejection, other relapsing-remitting inflammatory ..
  32. Population-scale HLA typing for home land defense
    KRISHNA JAYARAMAN; Fiscal Year: 2004
    ..Although directly enabled by the technology to be developed in this SBIR application, those other civilian & military applications will be pursued in follow-on grant applications. ..
  33. IMPROVED BLOOD SERVICE CARE FOR CYTOPENIC PATIENTS
    CHESTER ALPER; Fiscal Year: 2005
    ..The hypothesis that incomplete penetrance in these disorders is related to variation in susceptibility gene expression will be tested. ..
  34. NK CELL RECEPTOR RECOGNITION OF ORAL CANCERS
    Charles Lutz; Fiscal Year: 2004
    ..Via knowledge of tumor ligands and NK receptor signaling, better prevention and treatment of OC-SCC may be developed. ..
  35. Immunity to versican and ankylosing spondylitis
    Yiping Zhang; Fiscal Year: 2007
    ..We also intend to identify the role of HLA-B27 in the pathogenesis of the VGI/model using human HLA-B*2705 transgenic animals. ..
  36. Julie Horowitz; Fiscal Year: 2015
    ....
  37. LOCALIZED REVISION OF EPIGENETIC LANDSCAPES INDUCED BY DNA DOUBLE-STRAND BREAKS
    Barry P Sleckman; Fiscal Year: 2012
    ..We now propose to identify histone modifications that function as intermediates to coordinate the normal repair of DNA-DSBs in mammalian cells. ..
  38. Skin Homing T Cells -- Molecular Characterization of CLA
    Thomas S Kupper; Fiscal Year: 2012
    ..Knowledge generated from this grant application over the next five years will have a significant impact on both areas. ..
  39. Barry P Sleckman; Fiscal Year: 2016
    ..Furthermore, we will elucidate the mechanisms that lead to the frequent aberrant resolution of DNA breaks as chromosomal translocations in ATM-deficient cells. ..
  40. ACTIVATION OF CELLULAR SIGNALING PATHWAYS BY DNA DOUBLE STRAND BREAKS
    Barry P Sleckman; Fiscal Year: 2013
    ..Here, we propose to elucidate the genetic program initiated by H2AX, identify the transcriptional pathways that are activated, and determine how they are activated by H2AX. ..
  41. Karen E Hedin; Fiscal Year: 2015
    ....
  42. HIV-Induced CD4 T-Cell Depletion: An Innate Host Defense Gone Awry?
    Warner C Greene; Fiscal Year: 2013
    ..This approach could form a strong adjunct to traditional antiviral therapy and might be particularly beneficial for patients exhibiting broad drug resistance or rapid progression of disease. ..
  43. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..abstract_text> ..
  44. Pulmonary Interactions with Innate Immunity
    DAVID LINN PERKINS; Fiscal Year: 2013
    ..This proposal will examine biochemical and biological pathways that may lead to the development of candidates for therapeutic intervention for asthma. ..
  45. Anti-CTLA-4 Monoclonal Antibody Therapy for Lymphoma
    John Timmerman; Fiscal Year: 2005
    ..abstract_text> ..
  46. HUMAN T LYMPHOCYTE RESPONSE TO VIRAL ANTIGENS
    Thomas Braciale; Fiscal Year: 1991
    ..In addition, these studies should help to elucidate the similarities and differences in the mechanism of antigen presentation to "helper" and "killer" T lymphocytes and thereby provide an important framework for future vaccine design...
  47. Degeneracy and Complexity in the Immune System
    Eli Sercarz; Fiscal Year: 2006
    ..abstract_text> ..
  48. Characterization of V(D)J cleavage and repair complexes
    PATRICK SWANSON; Fiscal Year: 2007
    ..abstract_text> ..
  49. CCR4 IN SKIN LYMPHOCYTE HOMING AND IMMUNITY
    James Campbell; Fiscal Year: 2000
    ..These studies promise to define a critical component of lymphocyte recruitment to systemic sites inflammation, and may lead to novel therapeutic approaches in cutaneous (i.e. psoriasis) and other inflammatory diseases. ..
  50. Bimp3 in Antigen Receptor Signaling and MALT Lymphoma
    LINDA MCALLISTER LUCAS; Fiscal Year: 2007
    ..This training experience will ultimately lead to transition to the status of independent investigator. ..
  51. Structure Function Analysis of T Cell E-Selectin Ligands
    Robert Fuhlbrigge; Fiscal Year: 2007
    ..abstract_text> ..
  52. GENETICS OF HUMAN LYMPHOCYTE ANTIGEN CD8
    Paula Kavathas; Fiscal Year: 2001
    ..These cells have promise as immunotherapeutic agents by in vitro sensitization and injection into patients. Being able to target genes to this lineage could enhance the ability to develop these cells for immunotherapy. ..
  53. IMMUNOLOGY OF A MAJOR IDIOTYPE
    Jan Cerny; Fiscal Year: 1980
    ..The possible role of other self-determinants, in particular, products of MHC genes in recognition and differentiation of T15, will also be studied...
  54. Immunosuppression and regulatory T cells in aging
    Claire Chougnet; Fiscal Year: 2006
    ..abstract_text> ..
  55. Regulation of NK Cell Function by Vav-family Proteins
    Wojciech Swat; Fiscal Year: 2006
    ..ITAM-containing adaptors. Here, we propose to use several in vitro and in vivo approaches to determine Vav mechanism in NK cell function and development of natural cytotoxicity against virally-infected and tumor cells. ..
  56. GENETICS OF T-LYMPHOCYTE ANTIGEN RECEPTORS
    Edward Palmer; Fiscal Year: 1992
    ..Finally, we will study the effects of background genes on the positive selection of a single T cell receptor in a T cell receptor transgenic mouse...
  57. IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMA
    Jeffrey Weber; Fiscal Year: 2003
    ....
  58. Dendritic Cell Vaccination During Lymphoid Reconstitution
    Jeffrey Weber; Fiscal Year: 2008
    ..Toxicity as well as clinical response will be secondary endpoints. The cohort with the optimal level of immune response will be taken forward in future studies. ..
  59. CTLA-4 Inhibition and Autoimmunity in Melanoma
    Jeffrey Weber; Fiscal Year: 2008
    ..abstract_text> ..
  60. IL-12 as an Adjuvant for a Melanoma Peptide Vaccine
    Jeffrey Weber; Fiscal Year: 2003
    ..The results of those assays will be used to design randomized phase III trials for resected high risk melanoma and to develop strategies for overcoming antigen-specific unresponsiveness in melanoma patients. ..
  61. HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIA
    Jeffrey Weber; Fiscal Year: 2003
    ..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
  62. NEW GENETIC MARKERS FOR INSULIN-DEPENDENT DIABETES
    MICHAEL SHEEHY; Fiscal Year: 1990
    ..4. Determine if the degree of sharing of TCR alleles, by affected sibs, is (a) DR-identical versus 1 or 0 DR alleles shared. (b) Sharing or not sharing DR4...
  63. REG. OF T CELL AUTOREACTIVITY IN IDDM BY CTLA-4/CD152
    Jon Piganelli; Fiscal Year: 2001
    ..These studies will allow us to determine how a breakdown in peripheral tolerance due to defective function of CTLA-4 contributes to the autoimmune environment that results in IDDM. ..
  64. The function of membrane vesiculation in CTLA-4-mediate*
    Joonsoo Kang; Fiscal Year: 2005
    ..To date there has been limited advancement on the ability to increase CTLA-4 function. The proposed model of CTLA-4 function would provide a novel means to increase CTLA-4-mediated inhibition in vivo. ..
  65. FUNCTIONAL T CELL RECEPTOR GAMMA DELTA CELLS & GENES
    CHRISTINA PARKER; Fiscal Year: 1993
    ..The TCR gamma delta receptors from such patients will be characterized at the protein and gene level...