HIST1H4I

Summary

Gene Symbol: HIST1H4I
Description: histone cluster 1 H4 family member i
Alias: H4/m, H4FM, H4M, histone H4, H4 histone family, member M, Histone 4 family, member M, histone 1, H4i, histone cluster 1, H4i, histone family member
Species: human

Top Publications

  1. pmc MicroRNA-24 antagonism prevents renal ischemia reperfusion injury
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies, Department of Nephrology, and
    J Am Soc Nephrol 25:2717-29. 2014
  2. pmc Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2
    Takashi Umehara
    RIKEN Systems and Structural Biology Center, Tsurumi, Yokohama, Japan
    FEBS Lett 584:3901-8. 2010
  3. pmc Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
    Priya Aggarwal
    Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 18:329-40. 2010
  4. pmc The CH2 domain of CBP/p300 is a novel zinc finger
    Sangho Park
    Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    FEBS Lett 587:2506-11. 2013
  5. pmc SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
    Fen Yang
    Department of Biochemistry and Molecular Biology, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Health Science Center, Beijing, China
    EMBO J 31:110-23. 2012
  6. pmc PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation
    Jennifer K Sims
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Mol Cell Biol 28:4459-68. 2008
  7. pmc Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1
    N Kalakonda
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, New York, NY, USA
    Oncogene 27:4293-304. 2008
  8. pmc The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
    Matthieu Lacroix
    Institut de Genetique Moleculaire de Montpellier, Universite de Montpellier, Montpellier 34293, France
    EMBO Rep 9:452-8. 2008
  9. pmc Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP
    Hao Hu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Genes Dev 25:901-6. 2011
  10. doi Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis
    Niu Zhai
    Department of Biochemistry and Molecular Biology, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dongdan Santiao, Beijing 100005, China
    J Mol Cell Biol 4:231-41. 2012

Scientific Experts

  • Reiko Iida
  • Hengbin Wang
  • G Krett
  • Avinash Sonawane
  • Anne Philippi
  • Stefan Karger
  • Mingxing Zheng
  • Hu Zhang
  • Eric C Rouchka
  • Rashmirekha Pati
  • Mohamed Hassan
  • M Ceccon
  • Hsueh Wei Chang
  • Suguru Yamauchi
  • Daisuke Jitoku
  • Chunmin Ge
  • Johan M Lorenzen
  • Jayanth V Chodaparambil
  • Mulu Y Lubula
  • Ling Zhou
  • Roberta B Sciurano
  • M Evert
  • L Lundholm
  • Sebastian Bender
  • Sangho Park
  • T Schepeler
  • Sien Yi Sheu-Grabellus
  • Elizabeth B Evans
  • Chitra Venugopal
  • Cornelia Engelhardt
  • Niu Zhai
  • Kurt Werner Schmid
  • Dagmar Fuhrer
  • Q Li
  • Oliver Gimm
  • Fen Yang
  • Frédérick A Mallette
  • Kerstin Krause
  • Carl Weidinger
  • George J Cerniglia
  • Henning Dralle
  • Daniel Wratting
  • Alexander J Ruthenburg
  • Yi Hu
  • Arunkumar Anandharaj
  • Cai Tang
  • Xue Mei Jin
  • X F Mu
  • Hao Hu
  • Binyamin D Berkovits
  • Priya Aggarwal
  • Takashi Umehara
  • Jinu Lee
  • Haeryoung Kim
  • Y H Zhang
  • Jennifer K Sims
  • Lin Xu
  • Matthieu Lacroix
  • Simone Difilippantonio
  • N Kalakonda
  • W Albig
  • Marc A Holbert
  • Theresa Alenghat
  • Elena Di Pierro
  • Heinrich Schwindt
  • Jaw Yuan Wang
  • Donald L Evans
  • Stefano Amente
  • Xiao Feng Le
  • Yongzhao Zhao
  • Guiming Zhang
  • Zhuo Yu
  • Gengyun Sun
  • Da Yao
  • Maoqing Wu
  • Zhibing Zhu
  • Baotong Hua
  • Jianchao He
  • F Di Giacomo
  • Ishani Das
  • John W Eaton
  • C Gambacorti-Passerini
  • John K Kirtley
  • A D Manazza
  • S D Turner
  • Jen Yang Tang
  • Palaniappan Sethu
  • Dazhuo Li
  • Ching Yu Yen
  • Brigitte H Fasciotto

Detail Information

Publications73

  1. pmc MicroRNA-24 antagonism prevents renal ischemia reperfusion injury
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies, Department of Nephrology, and
    J Am Soc Nephrol 25:2717-29. 2014
    ..Therefore, miR-24 inhibition may be a promising future therapeutic option in the treatment of patients with ischemic AKI...
  2. pmc Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2
    Takashi Umehara
    RIKEN Systems and Structural Biology Center, Tsurumi, Yokohama, Japan
    FEBS Lett 584:3901-8. 2010
    ..mechanism for how the N-terminal bromodomain of human BRD2 (BRD2-BD1) deciphers the mono-acetylated status of histone H4 tail was recently reported...
  3. pmc Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
    Priya Aggarwal
    Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 18:329-40. 2010
    ..Importantly, human cancers harboring mutations in Fbx4, the cyclin D1 E3 ligase, exhibit nuclear cyclin D1 accumulation and increased PRMT5 activity...
  4. pmc The CH2 domain of CBP/p300 is a novel zinc finger
    Sangho Park
    Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    FEBS Lett 587:2506-11. 2013
    ..We tested the hypothesis that the bromodomain and the CH2 domain can interact with histones, but found that the CH2 does not participate in histone-recognition. ..
  5. pmc SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
    Fen Yang
    Department of Biochemistry and Molecular Biology, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Health Science Center, Beijing, China
    EMBO J 31:110-23. 2012
    ....
  6. pmc PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation
    Jennifer K Sims
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Mol Cell Biol 28:4459-68. 2008
    ..We previously discovered a novel trans-tail histone code involving monomethylated histone H4 lysine 20 (H4K20) and H3 lysine 9 (H3K9); however, the mechanisms that establish this code and its function in ..
  7. pmc Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1
    N Kalakonda
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, New York, NY, USA
    Oncogene 27:4293-304. 2008
    ..Our studies identify the importance of H4K20 monomethylation and of PR-SET7 for L3MBTL1 function...
  8. pmc The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
    Matthieu Lacroix
    Institut de Genetique Moleculaire de Montpellier, Universite de Montpellier, Montpellier 34293, France
    EMBO Rep 9:452-8. 2008
    ..PRMT5 bound to COPR5 methylates histone H4 (R3) preferentially when compared with histone H3 (R8), suggesting that COPR5 modulates the substrate ..
  9. pmc Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP
    Hao Hu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Genes Dev 25:901-6. 2011
    ..The crystal structure of an HJURP-CENP-A-histone H4 complex shows that HJURP binds a CENP-A-H4 heterodimer...
  10. doi Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis
    Niu Zhai
    Department of Biochemistry and Molecular Biology, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dongdan Santiao, Beijing 100005, China
    J Mol Cell Biol 4:231-41. 2012
    ..Here, we show that human PIH1 domain-containing protein 1 (PIH1) interacts directly with histone H4 and recruits the Brg1-SWI/SNF complex via SNF5 to human rRNA genes...
  11. pmc RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites
    Frédérick A Mallette
    Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Sir Mortimer B Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    EMBO J 31:1865-78. 2012
    ..of the ubiquitination cascade controlled by the E3 ubiquitin ligases RNF8 and RNF168, and methylation of histone H4 on lysine 20...
  12. pmc The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor
    Theresa Alenghat
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
    EMBO J 25:3966-74. 2006
    ..SNF2H does not interact directly with the N-CoR/HDAC3 complex, but binds to unacetylated histone H4 tails, suggesting that deacetylase activity of the corepressor complex is critical to SNF2H function...
  13. doi Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
    Sebastian Bender
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany
    Cancer Cell 24:660-72. 2013
    ....
  14. pmc Molecular functions of the TLE tetramerization domain in Wnt target gene repression
    Jayanth V Chodaparambil
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA
    EMBO J 33:719-31. 2014
    ..Furthermore, the TLE Q tetramer, not the dimer, binds to chromatin, specifically to K20 methylated histone H4 tails, suggesting that the TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate ..
  15. ncbi Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation
    Stefano Amente
    Department of Genetics, General and Molecular Biology, University of Naples Federico II Naples, Via Mezzocannone 8, 80134 Naples, Italy
    FEBS Lett 579:683-9. 2005
    ..We found that FCP1 is a genuine substrate of PRMT5-methylation both in vivo and in vitro, and FCP1-associated PRMT5 can methylate histones H4 in vitro...
  16. pmc Identification of the molecular mechanisms underlying dilated cardiomyopathy via bioinformatic analysis of gene expression profiles
    Hu Zhang
    Department of Cardiaovascular Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P R China
    Exp Ther Med 13:273-279. 2017
    ..chromatin assembly', 'protein-DNA complex assembly', 'nucleosome organization' and 'DNA packaging' (H1 histone family member 0, histone cluster 1 H1c, histone cluster 1 H2bd and H2A histone family member Z)...
  17. pmc Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase
    Partha Mitra
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Mol Cell Biol 23:8110-23. 2003
    ..characterized the critical transcription factor HiNF-P, which is required for E2F-independent activation of the histone H4 multigene family...
  18. doi Oridonin promotes G2/M arrest in A549 cells by facilitating ATM activation
    Mingxing Zheng
    Department of Respiratory Medicine, Clinical College of Anhui Medical University Affiliated Shenzhen Second People s Hospital, Shenzhen, Guangdong 518035, P R China
    Mol Med Rep 15:375-379. 2017
    ..serine/threonine kinase (S1981), p‑checkpoint kinase 2 (CHK2) (T68), p‑p53, and phosphorylated H2A histone family member X protein levels were visibly increased, indicating that oridonin promoted G2/M arrest in A549 cells ..
  19. doi Association study of H2AFZ with schizophrenia in a Japanese case-control sample
    Daisuke Jitoku
    Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, 113 0034, Japan
    J Neural Transm (Vienna) 122:915-23. 2015
    ....
  20. pmc BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1
    Chunmin Ge
    Department of Cancer and Cell Biology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267
    Proc Natl Acad Sci U S A 112:E1210-9. 2015
    ..These findings identify BRUCE and USP8 as two hitherto uncharacterized critical DDR regulators and uncover a deubiquitination regulation of BRIT1 assembly at damaged chromatin for efficient DDR and genomic stability. ..
  21. pmc Three proteins define a class of human histone deacetylases related to yeast Hda1p
    C M Grozinger
    Departments of Chemistry and Chemical Biology and Molecular and Cellular Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 96:4868-73. 1999
    ..However, HDAC4 and HDAC5 associate with HDAC3 in vivo. This finding suggests that the human class II HDAC enzymes may function in cellular processes distinct from those of HDAC1 and HDAC2...
  22. doi Replication-competent adenoviruses with the type 35-derived fiber-knob region achieve reactive oxygen species-dependent cytotoxicity and produce greater toxicity than those with the type 5-derived region in pancreatic carcinoma
    Suguru Yamauchi
    Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute, 666 2 Nitona, Chuo Ku, Chiba, 260 8717, Japan
    Apoptosis 20:1587-98. 2015
    ..Nevertheless, H2A histone family member X molecules were phosphorylated, and N-acetyl-L-cystein, an inhibitor for reactive oxygen species, ..
  23. ncbi The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes
    F Aziz
    Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA
    Mol Biol Rep 25:1-12. 1998
    Maximal transcription of a prototypical cell cycle controlled histone H4 gene requires a proliferation-specific in vivo genomic protein/DNA interaction element, Site II...
  24. pmc Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain
    Mulu Y Lubula
    Department of Pharmaceutical Science, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, USA
    FEBS Lett 588:3844-54. 2014
    ..Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition. ..
  25. doi Elevated Expression of Hepatoma Up-Regulated Protein Inhibits γ-Irradiation-Induced Apoptosis of Prostate Cancer Cells
    Mohamed Hassan
    Cancer Institute, University of Mississippi Medical Center, 2500 N State St Jackson, Mississippi, 39216
    J Cell Biochem 117:1308-18. 2016
    ..kinase1 (ASK1), c-jun-N-terminal kinase (JNK) and Ataxia-telangiectasia mutated (ATM) and histone family member X (H2AX)...
  26. pmc Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency
    M Ceccon
    Department of Health Science, University of Milano Bicocca, Monza, Italy
    Oncogene 35:3854-65. 2016
    ..phosphorylation and cell death through the engagement of an ATM/Chk2- and γH2AX (phosphorylated H2A histone family member X)-mediated DNA-damage response...
  27. doi Zinc-Oxide Nanoparticles Exhibit Genotoxic, Clastogenic, Cytotoxic and Actin Depolymerization Effects by Inducing Oxidative Stress Responses in Macrophages and Adult Mice
    Rashmirekha Pati
    School of Biotechnology, Campus 11 and
    Toxicol Sci 150:454-72. 2016
    ..evident by the formation of COMET tail, micronuclei, chromosomal fragmentation, and phosphorylation of H2A histone family member X...
  28. doi Synergistic anti-oral cancer effects of UVC and methanolic extracts of Cryptocarya concinna roots via apoptosis, oxidative stress and DNA damage
    Hsueh Wei Chang
    a Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan
    Int J Radiat Biol 92:263-72. 2016
    ..MitoMP change and H2A histone family member X (γH2AX; H2AFX)-based DNA damage were synergistically inhibited and induced by MECCrt/UVC compared to ..
  29. pmc Transcriptional profile of immediate response to ionizing radiation exposure
    Eric C Rouchka
    Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40292, United States Kentucky Biomedical Research Infrastructure Network Bioinformatics Core, University of Louisville, Louisville, KY 40292, United States
    Genom Data 7:82-5. 2016
    ..3 Gy) to high, potentially lethal, levels of radiation (3.0 Gy). The data described here is available in NCBI's Gene Expression Omnibus (GEO), accession GSE64375. ..
  30. doi Dissociation of the X chromosome from the synaptonemal complex in the XY body of the rodent Galea musteloides
    Roberta B Sciurano
    2da UA de Biología Celular, Histologia, Embriologia y Genetica, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 Piso 10 C1121ABG, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
    Chromosome Res 21:753-63. 2013
    ..It is shown that most of the SYCP3 protein associated with the X chromosome loop is not involved in the SC maintenance, but it is located with the cohesin axis separated from the SC proper...
  31. doi GBM secretome induces transient transformation of human neural precursor cells
    Chitra Venugopal
    Faculty of Health Sciences, McMaster University Stem Cell and Cancer Research Institute, McMaster University, 1280 Main Street West, MDCL 5027, Hamilton, ON, L8S 4K1, Canada
    J Neurooncol 109:457-66. 2012
    ..media by mass spectrometry reveals the presence of secreted proteins Chitinase-3-like 1 (CHI3L1) and H2A histone family member H2AX...
  32. pmc A conserved function for the H2A.Z C terminus
    Daniel Wratting
    Faculty of Life Sciences, University of Manchester M13 9PT, United Kingdom
    J Biol Chem 287:19148-57. 2012
    ..Z in both yeast and human cells are more loosely associated with chromatin than the full-length proteins, indicating a conserved function for the H2A.Z C-terminal tail in regulating the association of H2A.Z with nucleosomes...
  33. doi A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response
    T Schepeler
    Department of Molecular Medicine, Aarhus University Hospital, Skejby, Aarhus N, Denmark
    Oncogene 32:3577-86. 2013
    ..The DDR signaling as evaluated by phospho-epitope-specific antibodies against Ser139-phosphorylated H2A histone family member X (γH2AX), ataxia telangiectasia mutated (ATM), and ATM- and Rad3-related (ATR) was commonly activated in ..
  34. pmc Localization and regulation of murine Esco2 during male and female meiosis
    Elizabeth B Evans
    School of Molecular Biosciences and the Center for Reproductive Biology, Washington State University, Pullman, Washington, USA
    Biol Reprod 87:61. 2012
    ..ESCO2 colocalized with the gamma H2A histone family member X (H2AFX) in pachytene spermatocytes, indicating that ESCO2 is a component of the XY body...
  35. ncbi Distinct pattern of oxidative DNA damage and DNA repair in follicular thyroid tumours
    Stefan Karger
    Clinic of Endocrinology and Nephrology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, Liebigstrasse 18, 04103 Leipzig, Germany
    J Mol Endocrinol 48:193-202. 2012
    ..Furthermore, this study provides the first evidence for differences in oxidative stress defence in FTC variants with possible implications for therapeutic response and prognostic outcome...
  36. doi Distinct pattern of oxidative DNA damage and DNA repair in follicular thyroid tumours
    Stefan Karger
    Clinic of Endocrinology and Nephrology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, Liebigstraße 18, 04103 Leipzig, Germany
    J Mol Endocrinol 48:193-202. 2012
    ..Furthermore, this study provides the first evidence for differences in oxidative stress defence in FTC variants with possible implications for therapeutic response and prognostic outcome...
  37. ncbi Molecular cloning and polymorphism of the porcine H2AFZ gene
    Y H Zhang
    1Key Laboratory of Pig Genetics and Breeding of Ministry of Agriculture and Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, P R China
    Animal 3:779-82. 2009
    ..01) for number of piglets born alive, respectively. This result suggests that the pH2AFZ gene might be a good candidate gene of litter-size trait and provides some marker information for marker-assisted selection...
  38. pmc Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions
    Alexander J Ruthenburg
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA
    Cell 145:692-706. 2011
    ..Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations...
  39. pmc Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235
    George J Cerniglia
    Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Pharmacol 82:1230-40. 2012
    ..with DNA damage repair after radiation as measured by the CometAssay and resolution of phosphorylated H2A histone family member X foci...
  40. doi A theoretical study of the hydrogen-storage potential of (H2)4CH4 in metal organic framework materials and carbon nanotubes
    Q Li
    Department of Physics, Wake Forest University, NC 27109, USA
    J Phys Condens Matter 24:424204. 2012
    The hydrogen-methane compound (H(2))(4)CH(4)-or for short H4M-is one of the most promising hydrogen-storage materials. This van der Waals compound is extremely rich in molecular hydrogen: 33...
  41. pmc Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest
    L Lundholm
    Department of Oncology Pathology, Karolinska Biomics Center, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
    Cell Death Dis 4:e478. 2013
    ....
  42. doi Novel prognostic markers for patients with triple-negative breast cancer
    Ling Zhou
    Department of Surgery, Shanghai First People s Branch Hospital, Shanghai Jiaotong University, Shanghai 200081, China
    Hum Pathol 44:2180-7. 2013
    ..protein levels of cleaved caspase-3 (CC3), aldehyde dehydrogenase 1 (ALDH1), cyclooxygenase-2, Ki-67, H2A histone family member X, and phosphorylated protein kinase B protein were measured by immunohistochemical staining...
  43. pmc Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis thaliana
    Lin Xu
    Institut de Biologie Moléculaire des Plantes CNRS, 12 rue du Général Zimmer, 67084 Strasbourg Cedex, France
    Mol Cell Biol 28:1348-60. 2008
    ..Together our results reveal that the deposition of H3K36 methylation is finely regulated, possibly to cope with the complex regulation of growth and development in higher eukaryotes...
  44. pmc Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value
    M Evert
    Institut fur Pathologie, Universitätsmedizin Greifswald, Greifswald, Germany
    Br J Cancer 109:2654-64. 2013
    ..The DNA-repair gene DNA-dependent kinase catalytic subunit (DNA-PKcs) favours or inhibits carcinogenesis, depending on the cancer type. Its role in human hepatocellular carcinoma (HCC) is unknown...
  45. ncbi The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting
    Marc A Holbert
    The Wistar Institute and Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 0381, USA
    J Biol Chem 282:36603-13. 2007
    ..Our results reveal, for the first time, that enzymatic and DNA-targeting activities can be contained within the same chromatin regulatory domain...
  46. ncbi Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: correlation to activated K-ras oncogene
    Jaw Yuan Wang
    Department of Surgery, Faculty of Medicine, College of Medicine, and Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taipei, Taiwan
    Oncol Rep 16:1245-52. 2006
    ..Therefore, we propose that activated K-ras oncogene in colorectal adenomas may play an important role in the subsequent colorectal carcinogenesis through a group of K-ras-related molecular targets...
  47. ncbi A large deletion on chromosome 11 in acute intermittent porphyria
    Elena Di Pierro
    Department of Internal Medicine, Maggiore Policlinico, Mangiagalli and Regina Elena, Foundation IRCCS, University of Milan, Italy
    Blood Cells Mol Dis 37:50-4. 2006
    ..size of this deletion, single nucleotide polymorphisms (SNPs) analysis was extended to flanking genes, H2A Histone Family member X (H2AFX) and Dolichyl-Phosphate N-Acetylglucosamine Phosphotransferase 1 (DPAGT1), downstream and ..
  48. doi DNA damage-sensing kinases mediate the mouse 2-cell embryo's response to genotoxic stress
    X F Mu
    Human Reproduction Unit, Sydney Centre for Developmental and Regenerative Medicine, Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
    Biol Reprod 85:524-35. 2011
    ..Under conditions of extensive or persistent DNA damage, the demise of the embryo is the ultimate method of protecting genomic integrity...
  49. ncbi Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage
    Hengbin Wang
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Kaul Human Genetics Building Room 402A, 720 South 20th Street, 35294, USA
    Mol Cell 22:383-94. 2006
    ..Thus, our studies uncover CUL4-DDB-ROC1 as a histone ubiquitin ligase and demonstrate that histone H3 and H4 ubiquitylation participates in the cellular response to DNA damage...
  50. ncbi Histone H4 acetylation in human cells. Frequency of acetylation at different sites defined by immunolabeling with site-specific antibodies
    B M Turner
    School of Basic Medical Sciences, Anatomy Department, University of Birmingham Medical School, England
    FEBS Lett 253:141-5. 1989
    b>Histone H4 can be reversibly acetylated at lysine residues 5, 8, 12 and 16...
  51. ncbi Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene
    U Pauli
    Science 236:1308-11. 1987
    ..These protein-DNA interactions persist during all phases of the cell cycle and dissociate with 0.16 to 0.2M sodium chloride...
  52. ncbi A highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA
    K K Ebralidse
    Institute of Molecular Biology, Academy of Sciences, Moscow, USSR
    Nature 331:365-7. 1988
    ..4). DNA-histone chemical cross-linking within the core particle has revealed strong binding of each of the two histone H4 molecules to DNA at a distance of 1.5 helical turns either side of the nucleosomal dyad axis (sites +/- 1.5)...
  53. pmc Structure and in vitro transcription of a human H4 histone gene
    F Sierra
    Nucleic Acids Res 11:7069-86. 1983
    ..Data are presented which suggest that sequences located downstream from the 3' end of the coding region may influence the in vitro transcription of this human H4 histone gene...
  54. ncbi Association of histone H4 genes with the mammalian testis-specific H1t histone gene
    B Drabent
    Abt Molekularbiologie, Georg August Universitat Gottingen, Germany
    DNA Cell Biol 14:591-7. 1995
    ....
  55. ncbi A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5' regulatory region of BCL6 with a novel H4 histone gene
    T Akasaka
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Cancer Res 57:7-12. 1997
    ..Because H4 gene expression is tightly coupled to DNA replication, this study suggested an immediate mechanism for deregulated expression of BCL6, leading to the development of non-Hodgkin's lymphoma...
  56. ncbi Characterization of the H1.5 gene completes the set of human H1 subtype genes
    W Albig
    Institut fur Biochemie und Molekulare Zellbiologie, Universitaet Goettingen, Germany
    Gene 184:141-8. 1997
    ..The H2B sequence shows no typical regulatory elements and no complete ORF, therefore we consider it as a pseudogene. The expression of the H1.5 gene was examined in several cell lines...
  57. ncbi The human H2A and H2B histone gene complement
    W Albig
    Institut fur Biochemie und Molekulare Zellbiologie, Universitat Gottingen, Germany
    Biol Chem 380:7-18. 1999
    ..The genes show varying expression patterns in different tumor cell lines...
  58. ncbi The genomic organization of the histone clusters on human 6p21.3
    J Ahn
    Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, 464 Congress Avenue, New Haven, Connecticut 06520 8081, USA
    Mamm Genome 10:768-70. 1999
  59. pmc AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching
    S Petersen
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 414:660-5. 2001
    ..Here we report that the Nijmegen breakage syndrome protein (Nbs1) and phosphorylated H2A histone family member X (gamma-H2AX, also known as gamma-H2afx), which facilitate DNA double-strand break (DSB) repair, form ..
  60. ncbi Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling
    Xiao Feng Le
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:2092-104. 2005
    ..Transcriptional regulation by anti-HER2 antibody through PI3K-AKT pathway may potentiate the growth inhibitory activity of docetaxel by affecting cell cycle progression...
  61. ncbi Molecular characterization of a novel pattern recognition protein from nonspecific cytotoxic cells: sequence analysis, phylogenetic comparisons and anti-microbial activity of a recombinant homologue
    Donald L Evans
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Dev Comp Immunol 29:1049-64. 2005
    ..75. Sequence comparisons of this protein indicated similarity to zebrafish (51.2%) histone family member 1-X and (to a lesser extent) to trout H1...
  62. pmc The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background
    Binyamin D Berkovits
    Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA
    Dev Biol 360:358-68. 2011
    ..These observations suggest that the first bromodomain of Brdt is critical in the formation and/or maintenance of an intact chromocenter and implicate this structure in proper remodeling of the chromatin architecture of the sperm head...
  63. ncbi Chromosomal translocations fusing the BCL6 gene to different partner loci are recurrent in primary central nervous system lymphoma and may be associated with aberrant somatic hypermutation or defective class switch recombination
    Heinrich Schwindt
    Department of Neuropathology, University Hospital of Cologne, Koln, Germany
    J Neuropathol Exp Neurol 65:776-82. 2006
    ..DNA sequence analysis of the junctional sequences provided evidence that aberrant class switch recombination or somatic hypermutation may be involved in the generation of BCL6 translocations...
  64. pmc Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis
    Anne Philippi
    IntegraGen SA, 5 rue Henri Desbrueres, Genopole Campus 1, Genavenir 8, 91000 Evry, France
    BMC Med Genet 8:74. 2007
    ..the pituitary-hypothalamic axis, 2) neurogenin 1, a transcription factor involved in neurogenesis, and 3) histone family member Y (H2AFY), which is involved in X-chromosome inactivation in females and could explain the 4:1 male:female ..
  65. pmc 53BP1 facilitates long-range DNA end-joining during V(D)J recombination
    Simone Difilippantonio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1360, USA
    Nature 456:529-33. 2008
    ..breaks, where it seems to function in a subset of ataxia telangiectasia mutated (ATM) kinase-, H2A histone family member X (H2AX, also known as H2AFX)- and mediator of DNA damage checkpoint 1 (MDC1)-dependent events...
  66. doi Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertility
    Jinu Lee
    Department of Pharmacology, CHA Stem Cell Institute, School of Medicine, CHA University, Bundang gu, Seongnam si, Kyunggi Do, Korea
    J Cell Mol Med 13:1942-51. 2009
    ..Our data implicate H2BFWT as a susceptibility factor for male infertility, possibly with other genetic and environmental factors...
  67. doi Large liver cell change in hepatitis B virus-related liver cirrhosis
    Haeryoung Kim
    Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea
    Hepatology 50:752-62. 2009
    ..HBV-related LLCC showed significantly higher Tp53 labeling index, gamma-H2AX labeling index, and micronuclei index; shorter telomere length; decreased SA-beta-Gal activity; and increased net cellular gain compared to cholestatic LLCC...
  68. doi A polyphasic study on the species diversity of the sediment microbiota of Lake Hévíz
    G Krett
    Department of Microbiology, Eotvos Lorand University, Budapest, Hungary
    Acta Microbiol Immunol Hung 56:339-55. 2009
    ..Two clone libraries were constructed from H3M and H4M samples, providing 288 and 192 clones which were grouped to 150 and 125 OTUs, respectively, by ARDRA...
  69. doi Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy
    Arunkumar Anandharaj
    Department of Radiation Oncology, Chungbuk National University College of Medicine, Cheongju, Korea
    Acta Biochim Biophys Sin (Shanghai) 43:292-300. 2011
    ..in rapamycin pre-treatment glioblastoma cells followed by radiation; meanwhile, the phosphorylation of H2A histone family member X (H2AX) at serine-139 (γ-H2AX) was increased...
  70. ncbi Isolation and characterization of two human H1 histone genes within clusters of core histone genes
    W Albig
    Institut fur Biochemie, Universitat Gottingen, Federal Republic of Germany
    Genomics 10:940-8. 1991
    ..In continuation of our previous analysis of two human H1 genes, this analysis raises the number of completely sequenced H1 histone genes within clusters of core histone genes to four...
  71. doi H2AFX polymorphisms are associated with decreased risk of diffuse large B cell lymphoma in Koreans
    Xue Mei Jin
    Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun Gun, Chonnam, Republic of Korea
    DNA Cell Biol 30:1039-44. 2011
    Polymorphisms of the H2A histone family member X (H2AFX) gene have been associated with decreased non-Hodgkin lymphoma (NHL, -417AA) risk and increased breast cancer (1654AG/GG, and -1420GA/AA) risk...
  72. doi Hydration-sensitive gene expression in brain
    Cai Tang
    Department of Physiology, University of Tubingen, Gmelinstr 5, D 72076 Tubingen
    Cell Physiol Biochem 27:757-68. 2011
    ..discs large (Drosophila) homolog-associated protein 1, zinc finger and BTB domain containing 3, and H2A histone family member V...
  73. pmc Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse
    Yi Hu
    Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 108:17141-6. 2011
    ..This study identifies the chromatin regulator H2AFY as a potential biomarker associated with disease activity and pharmacodynamic response that may become useful for enabling disease-modifying therapeutics for HD...