HIST1H4B

Summary

Gene Symbol: HIST1H4B
Description: histone cluster 1 H4 family member b
Alias: H4/I, H4FI, histone H4, H4 histone family, member I, histone 1, H4b, histone cluster 1, H4b
Species: human

Top Publications

  1. pmc Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
    Priya Aggarwal
    Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 18:329-40. 2010
  2. pmc Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain
    Mulu Y Lubula
    Department of Pharmaceutical Science, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, USA
    FEBS Lett 588:3844-54. 2014
  3. pmc Molecular functions of the TLE tetramerization domain in Wnt target gene repression
    Jayanth V Chodaparambil
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA
    EMBO J 33:719-31. 2014
  4. pmc Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer
    Jian Shi
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40506, USA Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY 40506, USA
    Cancer Cell 25:210-25. 2014
  5. pmc Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release
    Wen Liu
    Howard Hughes Medical Institute, Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA School of Pharmaceutical Science, Xiamen University, Xiang an South Road, Xiamen, Fujian 361102, China Electronic address
    Cell 155:1581-95. 2013
  6. pmc The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics
    Tara K Sigdel
    California Pacific Medical Center Research Institute, 475 Brannan St, Ste 220, San Francisco, California 9410
    Mol Cell Proteomics 13:621-31. 2014
  7. doi Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
    Sebastian Bender
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany
    Cancer Cell 24:660-72. 2013
  8. pmc The CH2 domain of CBP/p300 is a novel zinc finger
    Sangho Park
    Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    FEBS Lett 587:2506-11. 2013
  9. pmc RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites
    Frédérick A Mallette
    Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Sir Mortimer B Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    EMBO J 31:1865-78. 2012
  10. doi Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis
    Niu Zhai
    Department of Biochemistry and Molecular Biology, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dongdan Santiao, Beijing 100005, China
    J Mol Cell Biol 4:231-41. 2012

Scientific Experts

  • Jian Shi
  • Mulu Y Lubula
  • Jayanth V Chodaparambil
  • Tara K Sigdel
  • Sebastian Bender
  • Wen Liu
  • Sangho Park
  • Frédérick A Mallette
  • Niu Zhai
  • Jennifer Maselli
  • Fen Yang
  • Daniel Wratting
  • Alexander J Ruthenburg
  • Hao Hu
  • Priya Aggarwal
  • Takashi Umehara
  • Guohong Li
  • Jennifer K Sims
  • N Kalakonda
  • Matthieu Lacroix
  • Patrick Trojer
  • Theresa Alenghat
  • Danny Reinberg
  • Stefano Amente
  • Bing Xiao
  • Partha Mitra
  • Van Dinh
  • Brian E Eckenroth
  • Minnie M Sarwal
  • Guangtao Zhang
  • William I Weis
  • Yiwei Lin
  • Becky P Tsai
  • Haining Zhu
  • Szu Chuan Hsieh
  • Soyoung Ryu
  • Carrie D Nicora
  • Uma M Muthurajan
  • Ming Ming Zhou
  • Marian L Waterman
  • Minh Thien-Vu
  • Chi Wang
  • Wenzhong Xiao
  • Amanda Poplawski
  • David G Camp
  • Samuel Carlson
  • Jiong Deng
  • Daniel J Orton
  • Margretta R D Hepler
  • B Mark Evers
  • Jun Yao
  • Elena Rusinova
  • Hong Dai
  • Junlin Li
  • Karolin Luger
  • Nathan Salomonis
  • Wei Jun Qian
  • Kira T Pate
  • Binhua P Zhou
  • Yifan Wang
  • Karen C Glass
  • Tiebang Kang
  • Maksymilian Chruszcz
  • Yi Xin Zeng
  • Qiang Zhang
  • Yadi Wu
  • Lei Zeng
  • Min Tao
  • Richard D Smith
  • Ronald J Moore
  • Jintang He
  • Nathalène Truffaux
  • Volker Hovestadt
  • Michelle Monje
  • Bernhard Radlwimmer
  • Yujie Tang
  • Christoph Plass
  • Spenser Chen
  • Andreas von Deimling
  • Olaf Witt
  • Yoon Jae Cho
  • David T W Jones
  • Dominik Sturm
  • Peter E Wright
  • Huriye Seker-Cin
  • Marina Ryzhova
  • Kaki Wong
  • Marcel Kool
  • Qi Ma
  • Jonas W Højfeldt

Detail Information

Publications29

  1. pmc Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
    Priya Aggarwal
    Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, 19104, USA
    Cancer Cell 18:329-40. 2010
    ..Importantly, human cancers harboring mutations in Fbx4, the cyclin D1 E3 ligase, exhibit nuclear cyclin D1 accumulation and increased PRMT5 activity...
  2. pmc Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain
    Mulu Y Lubula
    Department of Pharmaceutical Science, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, USA
    FEBS Lett 588:3844-54. 2014
    ..Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition. ..
  3. pmc Molecular functions of the TLE tetramerization domain in Wnt target gene repression
    Jayanth V Chodaparambil
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA
    EMBO J 33:719-31. 2014
    ..Furthermore, the TLE Q tetramer, not the dimer, binds to chromatin, specifically to K20 methylated histone H4 tails, suggesting that the TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate ..
  4. pmc Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer
    Jian Shi
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40506, USA Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY 40506, USA
    Cancer Cell 25:210-25. 2014
    ..Twist contains a "histone H4-mimic" GK-X-GK motif that is diacetylated by Tip60...
  5. pmc Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release
    Wen Liu
    Howard Hughes Medical Institute, Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA School of Pharmaceutical Science, Xiamen University, Xiang an South Road, Xiamen, Fujian 361102, China Electronic address
    Cell 155:1581-95. 2013
    ..The functions of JMJD6/ Brd4-associated dual histone and RNA demethylase activity on anti-pause enhancers have intriguing implications for these proteins in development, homeostasis, and disease. ..
  6. pmc The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics
    Tara K Sigdel
    California Pacific Medical Center Research Institute, 475 Brannan St, Ste 220, San Francisco, California 9410
    Mol Cell Proteomics 13:621-31. 2014
    ..01; fold increase >1.5) from all other transplant categories (HLA class II protein HLA-DRB1, KRT14, HIST1H4B, FGG, ACTB, FGB, FGA, KRT7, DPP4). Increased levels of three of these proteins, fibrinogen beta (FGB; p = 0...
  7. doi Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
    Sebastian Bender
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany
    Cancer Cell 24:660-72. 2013
    ....
  8. pmc The CH2 domain of CBP/p300 is a novel zinc finger
    Sangho Park
    Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    FEBS Lett 587:2506-11. 2013
    ..We tested the hypothesis that the bromodomain and the CH2 domain can interact with histones, but found that the CH2 does not participate in histone-recognition. ..
  9. pmc RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites
    Frédérick A Mallette
    Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Sir Mortimer B Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    EMBO J 31:1865-78. 2012
    ..of the ubiquitination cascade controlled by the E3 ubiquitin ligases RNF8 and RNF168, and methylation of histone H4 on lysine 20...
  10. doi Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis
    Niu Zhai
    Department of Biochemistry and Molecular Biology, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5 Dongdan Santiao, Beijing 100005, China
    J Mol Cell Biol 4:231-41. 2012
    ..Here, we show that human PIH1 domain-containing protein 1 (PIH1) interacts directly with histone H4 and recruits the Brg1-SWI/SNF complex via SNF5 to human rRNA genes...
  11. pmc SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
    Fen Yang
    Department of Biochemistry and Molecular Biology, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Health Science Center, Beijing, China
    EMBO J 31:110-23. 2012
    ....
  12. pmc Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions
    Alexander J Ruthenburg
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA
    Cell 145:692-706. 2011
    ..Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations...
  13. pmc Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP
    Hao Hu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Genes Dev 25:901-6. 2011
    ..The crystal structure of an HJURP-CENP-A-histone H4 complex shows that HJURP binds a CENP-A-H4 heterodimer...
  14. pmc Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2
    Takashi Umehara
    RIKEN Systems and Structural Biology Center, Tsurumi, Yokohama, Japan
    FEBS Lett 584:3901-8. 2010
    ..mechanism for how the N-terminal bromodomain of human BRD2 (BRD2-BD1) deciphers the mono-acetylated status of histone H4 tail was recently reported...
  15. pmc PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation
    Jennifer K Sims
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Mol Cell Biol 28:4459-68. 2008
    ..We previously discovered a novel trans-tail histone code involving monomethylated histone H4 lysine 20 (H4K20) and H3 lysine 9 (H3K9); however, the mechanisms that establish this code and its function in ..
  16. pmc Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1
    N Kalakonda
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, New York, NY, USA
    Oncogene 27:4293-304. 2008
    ..Our studies identify the importance of H4K20 monomethylation and of PR-SET7 for L3MBTL1 function...
  17. pmc The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5
    Matthieu Lacroix
    Institut de Genetique Moleculaire de Montpellier, Universite de Montpellier, Montpellier 34293, France
    EMBO Rep 9:452-8. 2008
    ..PRMT5 bound to COPR5 methylates histone H4 (R3) preferentially when compared with histone H3 (R8), suggesting that COPR5 modulates the substrate ..
  18. ncbi L3MBTL1, a histone-methylation-dependent chromatin lock
    Patrick Trojer
    Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA
    Cell 129:915-28. 2007
    ..this, we found that the L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono- and dimethylation of histone H4 lysine 20 and of histone H1b lysine 26...
  19. pmc The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor
    Theresa Alenghat
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
    EMBO J 25:3966-74. 2006
    ..SNF2H does not interact directly with the N-CoR/HDAC3 complex, but binds to unacetylated histone H4 tails, suggesting that deacetylase activity of the corepressor complex is critical to SNF2H function...
  20. pmc Specificity and mechanism of the histone methyltransferase Pr-Set7
    Bing Xiao
    National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom
    Genes Dev 19:1444-54. 2005
    ..the crystal structure of a ternary complex of the enzyme Pr-Set7 (also known as Set8) that methylates Lys 20 of histone H4 (H4-K20)...
  21. ncbi Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation
    Stefano Amente
    Department of Genetics, General and Molecular Biology, University of Naples Federico II Naples, Via Mezzocannone 8, 80134 Naples, Italy
    FEBS Lett 579:683-9. 2005
    ..We found that FCP1 is a genuine substrate of PRMT5-methylation both in vivo and in vitro, and FCP1-associated PRMT5 can methylate histones H4 in vitro...
  22. pmc Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase
    Partha Mitra
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Mol Cell Biol 23:8110-23. 2003
    ..characterized the critical transcription factor HiNF-P, which is required for E2F-independent activation of the histone H4 multigene family...
  23. pmc Three proteins define a class of human histone deacetylases related to yeast Hda1p
    C M Grozinger
    Departments of Chemistry and Chemical Biology and Molecular and Cellular Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 96:4868-73. 1999
    ..However, HDAC4 and HDAC5 associate with HDAC3 in vivo. This finding suggests that the human class II HDAC enzymes may function in cellular processes distinct from those of HDAC1 and HDAC2...
  24. ncbi The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes
    F Aziz
    Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA
    Mol Biol Rep 25:1-12. 1998
    Maximal transcription of a prototypical cell cycle controlled histone H4 gene requires a proliferation-specific in vivo genomic protein/DNA interaction element, Site II...
  25. ncbi Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene
    U Pauli
    Science 236:1308-11. 1987
    ..These protein-DNA interactions persist during all phases of the cell cycle and dissociate with 0.16 to 0.2M sodium chloride...
  26. pmc Exposure to bleomycin, etoposide, and cis-platinum alters rat sperm chromatin integrity and sperm head protein profile
    Jennifer Maselli
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    Biol Reprod 86:166, 1-10. 2012
    ..2), HIST1H4B (H4), HIST2H2AA3 (H2A1), and HIST1H2BA (H2B1A) were concomitantly up-regulated; this was not observed in the ..
  27. pmc A conserved function for the H2A.Z C terminus
    Daniel Wratting
    Faculty of Life Sciences, University of Manchester M13 9PT, United Kingdom
    J Biol Chem 287:19148-57. 2012
    ..Z in both yeast and human cells are more loosely associated with chromatin than the full-length proteins, indicating a conserved function for the H2A.Z C-terminal tail in regulating the association of H2A.Z with nucleosomes...
  28. ncbi Isolation and characterization of two human H1 histone genes within clusters of core histone genes
    W Albig
    Institut fur Biochemie, Universitat Gottingen, Federal Republic of Germany
    Genomics 10:940-8. 1991
    ..In continuation of our previous analysis of two human H1 genes, this analysis raises the number of completely sequenced H1 histone genes within clusters of core histone genes to four...
  29. ncbi A 1.1-Mb transcript map of the hereditary hemochromatosis locus
    D A Ruddy
    Mercator Genetics, Menlo Park, California 94025, USA
    Genome Res 7:441-56. 1997
    ..1-Mb region may be derived from noncoding genomic DNA...