HIST1H3A

Summary

Gene Symbol: HIST1H3A
Description: histone cluster 1 H3 family member a
Alias: H3/A, H3FA, histone H3.1, H3 histone family, member A, histone 1, H3a, histone H3/a, histone cluster 1, H3a
Species: human

Top Publications

  1. ncbi Regulation of chromatin structure by site-specific histone H3 methyltransferases
    S Rea
    Research Institute of Molecular Pathology, The Vienna Biocenter, Austria
    Nature 406:593-9. 2000
  2. ncbi Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes
    J Y Hsu
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville 22908, USA
    Cell 102:279-91. 2000
  3. pmc ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor
    E Citterio
    Medical Genetic Center, Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 20:7643-53. 2000
  4. ncbi Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    M Lachner
    Research Institute of Molecular Pathology, The Vienna Biocenter, Vienna, Austria
    Nature 410:116-20. 2001
  5. ncbi Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor
    Liu Yang
    Medical Research Service, VA Puget Sound Health Care System, University of Washington, Seattle, Washington, WA 98108, USA
    Oncogene 21:148-52. 2002
  6. pmc Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation
    Kenichi Nishioka
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 16:479-89. 2002
  7. ncbi Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9
    Peter R Nielsen
    Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Nature 416:103-7. 2002
  8. ncbi ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
    Tatsuya Nakamura
    Kimmel Cancer Center and Department of Microbiology, Jefferson Medical College, Philadelphia, PA 19107, USA
    Mol Cell 10:1119-28. 2002
  9. ncbi Crosstalk between CARM1 methylation and CBP acetylation on histone H3
    Sylvain Daujat
    Wellcome Cancer Research UK Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Curr Biol 12:2090-7. 2002
  10. ncbi Structure and catalytic mechanism of the human histone methyltransferase SET7/9
    Bing Xiao
    Structural Biology Group, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Nature 421:652-6. 2003

Scientific Experts

Detail Information

Publications113 found, 100 shown here

  1. ncbi Regulation of chromatin structure by site-specific histone H3 methyltransferases
    S Rea
    Research Institute of Molecular Pathology, The Vienna Biocenter, Austria
    Nature 406:593-9. 2000
    ..Our data reveal a functional interdependence of site-specific H3 tail modifications and suggest a dynamic mechanism for the regulation of higher-order chromatin...
  2. ncbi Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes
    J Y Hsu
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville 22908, USA
    Cell 102:279-91. 2000
    ..Our findings reveal an enzyme system that regulates chromosome dynamics and controls histone phosphorylation that is conserved among diverse eukaryotes...
  3. pmc ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor
    E Citterio
    Medical Genetic Center, Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 20:7643-53. 2000
    ..CSB is the first repair protein found to play a direct role in modulating nucleosome structure. The relevance of this finding to the interplay between transcription and repair is discussed...
  4. ncbi Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    M Lachner
    Research Institute of Molecular Pathology, The Vienna Biocenter, Vienna, Austria
    Nature 410:116-20. 2001
    ..Our data define a molecular mechanism through which the SUV39H-HP1 methylation system can contribute to the propagation of heterochromatic subdomains in native chromatin...
  5. ncbi Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor
    Liu Yang
    Medical Research Service, VA Puget Sound Health Care System, University of Washington, Seattle, Washington, WA 98108, USA
    Oncogene 21:148-52. 2002
    ..Together, these findings raise the possibility that transcription factor ERG may participate in transcriptional regulation through ESET-mediated histone methylation...
  6. pmc Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation
    Kenichi Nishioka
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 16:479-89. 2002
    ....
  7. ncbi Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9
    Peter R Nielsen
    Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Nature 416:103-7. 2002
    ..These findings predict which other chromodomains will bind methylated proteins and suggest a motif that they recognize...
  8. ncbi ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
    Tatsuya Nakamura
    Kimmel Cancer Center and Department of Microbiology, Jefferson Medical College, Philadelphia, PA 19107, USA
    Mol Cell 10:1119-28. 2002
    ..In parallel, H3-K4 is methylated, and histones H3 and H4 are acetylated at this promoter...
  9. ncbi Crosstalk between CARM1 methylation and CBP acetylation on histone H3
    Sylvain Daujat
    Wellcome Cancer Research UK Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Curr Biol 12:2090-7. 2002
    ....
  10. ncbi Structure and catalytic mechanism of the human histone methyltransferase SET7/9
    Bing Xiao
    Structural Biology Group, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Nature 421:652-6. 2003
    ....
  11. ncbi Direct binding of INHAT to H3 tails disrupted by modifications
    Robert Schneider
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom
    J Biol Chem 279:23859-62. 2004
    ..We suggest that the charge of the histone tail is a major determinant in allowing INHAT to bind chromatin and coordinate the activity of multiple histone acetyltransferases...
  12. ncbi A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression
    Sara N Kutney
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:30850-5. 2004
    ..Together, these data define a novel in vivo mechanistic role for the mammalian Set/TAF-Ibeta and pp32 proteins as transducers of chromatin signaling by integrating chromatin hypoacetylation and transcriptional repression...
  13. ncbi Regulation of p53 activity through lysine methylation
    Sergei Chuikov
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nature 432:353-60. 2004
    ..The crystal structure of a ternary complex of Set9 with a p53 peptide and the cofactor product S-adenosyl-l-homocysteine (AdoHcy) provides the molecular basis for recognition of p53 by this lysine methyltransferase...
  14. ncbi Human Asf1 regulates the flow of S phase histones during replicational stress
    Anja Groth
    Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell 17:301-11. 2005
    ....
  15. ncbi WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development
    Joanna Wysocka
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Cell 121:859-72. 2005
    ..Our results are the first demonstration that a WD40-repeat protein acts as a module for recognition of a specific histone modification and suggest a mechanism for reading and writing an epigenetic mark for gene activation...
  16. ncbi Regulation of LSD1 histone demethylase activity by its associated factors
    Yu Jiang Shi
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Mol Cell 19:857-64. 2005
    ..Taken together, these findings suggest that LSD1-mediated histone demethylation is regulated dynamically in vivo. This is expected to have profound effects on gene expression under both physiological and pathological conditions...
  17. ncbi Expression patterns and post-translational modifications associated with mammalian histone H3 variants
    Sandra B Hake
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 281:559-68. 2006
    ..1 and H3.2 in mammalian cells should not be treated as equivalent proteins...
  18. ncbi Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases
    Johnathan R Whetstine
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Cell 125:467-81. 2006
    ..Our finding that this family of demethylases generates different methylated states at the same lysine residue provides a mechanism for fine-tuning histone methylation...
  19. ncbi A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
    Joanna Wysocka
    Laboratory of Chromatin Biology
    Nature 442:86-90. 2006
    ..We also identify a previously unknown function for the PHD finger as a highly specialized methyl-lysine-binding domain...
  20. ncbi The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
    Robert J Klose
    Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Nature 442:312-6. 2006
    ....
  21. ncbi The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
    Paul A C Cloos
    Biotech Research and Innovation Centre, Fruebjergvej 3, 2100 Copenhagen, Denmark
    Nature 442:307-11. 2006
    ..Thus, in addition to identifying GASC1 as a histone trimethyl demethylase, we suggest a model for how this enzyme might be involved in cancer development, and propose it as a target for anti-cancer therapy...
  22. pmc The nucleosome assembly activity of NAP1 is enhanced by Alien
    Maren Eckey
    Institute of Human Genetics and Anthropology, Friedrich Schiller University, 07740 Jena, Germany
    Mol Cell Biol 27:3557-68. 2007
    ..Based on these findings, we present here a novel pathway linking corepressor function with nucleosome assembly activity...
  23. pmc Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP
    Daniel R Foltz
    Ludwig Institute for Cancer Research, La Jolla, CA 92093 0670, USA
    Cell 137:472-84. 2009
    ..We propose HJURP to be a cell-cycle-regulated CENP-A-specific histone chaperone required for centromeric chromatin assembly...
  24. pmc JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
    Mark A Dawson
    Cambridge Institute for Medical Research and Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Nature 461:819-22. 2009
    ..Tauhese results identify a previously unrecognized nuclear role for JAK2 in the phosphorylation of H3Y41 and reveal a direct mechanistic link between two genes, jak2 and lmo2, involved in normal haematopoiesis and leukaemia...
  25. pmc Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association
    Henriette Franz
    Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    J Biol Chem 284:35049-59. 2009
    ..We suggest that similar multivalent binding stably anchors other histone modification binding factors on their target chromatin regions...
  26. doi PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation
    Weijun Feng
    Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
    Nat Struct Mol Biol 17:445-50. 2010
    ....
  27. pmc A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation
    Daniela Kleine-Kohlbrecher
    Biotech Research and Innovation Centre BRIC, Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
    Mol Cell 38:165-78. 2010
    ....
  28. pmc SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53
    Zhanyun Tang
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA
    Cell 154:297-310. 2013
    ..These results establish a mechanism in which SET1C and p300 act cooperatively, through direct interactions and coupled histone modifications, to facilitate the function of p53. ..
  29. pmc Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75
    Christopher E Berndsen
    Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Struct Mol Biol 15:948-56. 2008
    ..Together, these data provide evidence for a multifunctional HAT-chaperone complex that acetylates histone H3 and deposits H3-H4 onto DNA, linking histone modification and nucleosome assembly...
  30. pmc CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis
    S G Zeitlin
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 155:1147-57. 2001
    ..Our data support a model where CENP-A phosphorylation is involved in regulating Aurora B, INCENP, and PP1gamma1 targeting within the cell. These experiments identify an unexpected role for the kinetochore in regulation of cytokinesis...
  31. ncbi Selective recognition of acetylated histones by bromodomain proteins visualized in living cells
    Tomohiko Kanno
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 13:33-43. 2004
    ..Thus the recognition of histone acetylation code by bromodomains is selective, is involved in transcription, and potentially conveys transcriptional memory across cell divisions...
  32. ncbi The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains
    Young Bong Choi
    Sungkyunkwan University School of Medicine and Samsung Biomedical Research Institute, Suwon Si, Kyonggi do 440 746, Republic of Korea
    J Biol Chem 279:50930-41. 2004
    ..Thus PELP1 promotes and maintains the hypoacetylated state of histones at the target genomic site, and ER binding reverses its role to hyperacetylate histones through an as yet unidentified mechanism...
  33. pmc Histone modifications defining active genes persist after transcriptional and mitotic inactivation
    Antigone Kouskouti
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Herakleion, Crete, Greece
    EMBO J 24:347-57. 2005
    ..The findings suggest that histone modifications may function as molecular memory bookmarks for previously active locations of the genome, thus contributing to the maintenance of active chromatin states through cell division...
  34. ncbi Substrate preferences of the EZH2 histone methyltransferase complex
    Cyrus Martin
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    J Biol Chem 281:8365-70. 2006
    ..Our work supports the hypothesis that linker histone H1 and chromatin structure are important factors in determining the substrate preference of the EZH2 histone methyltransferase complex...
  35. pmc The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation
    Hina Naeem
    Cancer Research Laboratories, London Regional Cancer Program, London, Ontario, Canada N6A 4L6
    Mol Cell Biol 27:120-34. 2007
    ..Collectively, our data highlight coactivator methylation as an important regulatory mechanism in hormonal signaling...
  36. ncbi Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4
    Alicia Palacios
    NMR Group, Centro Nacional de Investigaciones Oncologicas CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    FEBS Lett 580:6903-8. 2006
    ..In contrast to ING2, ING4 is not a phosphoinositide receptor and binds with similar affinity to the different methylation states of histone-3 at lysine 4...
  37. pmc The double-histone-acetyltransferase complex ATAC is essential for mammalian development
    Sebastián Guelman
    Department of Pathology, Genentech Inc, 1 DNA Way MS 72B, South San Francisco, CA 94080, USA
    Mol Cell Biol 29:1176-88. 2009
    ....
  38. doi Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation
    Alessio Zippo
    Dipartimento di Biologia Molecolare Università di Siena, Siena, Italy
    Cell 138:1122-36. 2009
    ..Thus, the single phosphorylation H3S10ph at the FOSL1 enhancer triggers a cascade of events which activate transcriptional elongation...
  39. pmc RCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complex
    Joseph R England
    Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, 108 Althouse Laboratory, The Pennsylvania State University, University Park, PA 16802 1014, USA
    J Mol Biol 398:518-29. 2010
    ....
  40. pmc Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1
    Reiko Matsuyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 285:18166-76. 2010
    ..These results show that DPF2 acts as a nuclear receptor-selective co-repressor for ERRalpha by associating with both acetylated histone H3 and HDAC1...
  41. doi Structures of human nucleosomes containing major histone H3 variants
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162 8480, Japan
    Acta Crystallogr D Biol Crystallogr 67:578-83. 2011
    ..1 nucleosome. Since the amino-acid residues specific for H3.2 and H3.3 are located on the accessible surface of the H3/H4 tetramer, they may be potential interaction sites for H3.2- and H3.3-specific chaperones...
  42. doi Akt2 interacts with Snail1 in the E-cadherin promoter
    P Villagrasa
    Programa de Recerca en Càncer, IMIM Hospital del Mar, Barcelona, Spain
    Oncogene 31:4022-33. 2012
    ..These results uncover an unexpected role of Akt2 in transcriptional control and point out to phosphorylation of Thr45 in histone H3 as a new epigenetic mark related to Snail1 and Akt2 action...
  43. pmc ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair
    Jean Yves Bleuyard
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    EMBO Rep 13:135-41. 2012
    ..These results suggest that PALB2 chromatin association via ChAM facilitates PALB2 function in the cellular resistance to DNA damage...
  44. pmc H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
    Clemens Bönisch
    Department of Molecular Biology, Adolf Butenandt Institute, Ludwig Maximilians University Munich, 80336 Munich, Germany
    Nucleic Acids Res 40:5951-64. 2012
    ..Our findings enrich the list of known human variants by an unusual protein belonging to the H2A.Z family that leads to the least stable nucleosome known to date...
  45. pmc The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components
    Monica Soldi
    Department of Experimental Oncology, European Institute of Oncology IEO, Via Adamello 16, Milan, Italy
    Mol Cell Proteomics 12:764-80. 2013
    ..X and WICH, both enriched in silent domains. Chromatin proteomics expands the arsenal of tools for deciphering how all the distinct protein components act together to enforce a given region-specific chromatin status...
  46. pmc A small molecule inhibitor of fungal histone acetyltransferase Rtt109
    Jessica Lopes da Rosa
    Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, 364 Plantation St, LRB506, Worcester, MA 01605, USA
    Bioorg Med Chem Lett 23:2853-9. 2013
    ..This compound inhibits Rtt109 regardless of which histone chaperone cofactor protein (Asf1 or Vps75) is present, and appears to inhibit Rtt109 via a tight-binding, uncompetitive mechanism...
  47. pmc Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation
    Anamika Patel
    From the Department of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, Syracuse, New York 13210
    J Biol Chem 289:868-84. 2014
    ..Taken together, these results are consistent with a "two-active site" model for multiple H3K4 methylation by the MLL1 core complex. ..
  48. pmc Inhibition of histone binding by supramolecular hosts
    Hillary F Allen
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, U S A
    Biochem J 459:505-12. 2014
    ..The results of the present study suggest that the aromatic macrocyclic hosts can be used as a powerful new tool for characterizing methylation-driven epigenetic mechanisms...
  49. doi Histone H3 is Digested by Granzyme A During Compromised Cell Death in the Raji Cells
    Phil Young Lee
    Functional Genomics Research Center, KRIBB, 305 806, Daejeon, Republic of Korea
    J Microbiol Biotechnol 25:1578-82. 2015
    ..Taken together, we verified that histone H3 is a real substrate for GzmA in vivo in the Raji cells treated by staurosporin...
  50. pmc The Polycomb Repressive Complex 1 Protein BMI1 Is Required for Constitutive Heterochromatin Formation and Silencing in Mammalian Somatic Cells
    Mohamed Abdouh
    From the Department of Neurosciences, University of Montreal, and The Stem Cell and Developmental Biology Laboratory, Hopital Maisonneuve Rosemont, 5415 Boul l Assomption, Montréal H1T 2M4, Canada
    J Biol Chem 291:182-97. 2016
    ..These observations suggest a dynamic and developmentally regulated model of PRC1 occupancy at constitutive heterochromatin, and where BMI1 function in somatic cells is to stabilize the repetitive genome. ..
  51. ncbi A novel estrogen receptor alpha-associated protein alters receptor-deoxyribonucleic acid interactions and represses receptor-mediated transcription
    Margaret A Loven
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801, USA
    Mol Endocrinol 18:2649-59. 2004
    ....
  52. ncbi Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3
    Neil MacDonald
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, United Kingdom
    Mol Cell 20:199-211. 2005
    ..14-3-3 isoforms thus represent a class of proteins that mediate the effect of histone phosphorylation at inducible genes...
  53. pmc Roles of coactivators in hypoxic induction of the erythropoietin gene
    Feng Wang
    Department of Pathology and Laboratory Medicine, and Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 5:e10002. 2010
    ..How/whether p300/CBP and the members of p160 coactivator family potentiate hypoxic induction of endogenous EPO and other HIF-2alpha and hypoxia-inducible factor 1alpha (HIF-1alpha) target genes remains unclear...
  54. doi The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3
    Jessica M Jones
    The Department of Biochemistry, Molecular and Cellular Biology, Georgetown University, Washington, DC 20057, USA
    Immunol Lett 136:156-62. 2011
    ..A complex including damage-DNA binding protein has also been shown to ubiquitylate H3 in response to UV treatment, suggesting the H3 ubiquitylation may be a common step in multiple DNA repair pathways...
  55. doi Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells
    Jun Okabe
    Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Circ Res 110:1067-76. 2012
    ..The precise mechanism whereby chromatin structure and subsequent gene expression are regulated by glucose in vascular endothelial cells remain to be fully defined...
  56. doi Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins
    Melanie A Adams-Cioaba
    Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
    FEBS Lett 586:859-65. 2012
    ..We also confirm previous studies suggesting that the second Tudor domain of PHF20 exhibits preference for dimethylated histone substrates...
  57. pmc Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription
    Jiacai Wu
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 109:5675-80. 2012
    ....
  58. pmc The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts
    Andreas Janzer
    Institute of Pathology, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    J Biol Chem 287:30984-92. 2012
    ..In summary, our data reveal a regulatory role of Fbxl10 in cell morphology, chemokine expression, and the metabolic control of fibroblasts...
  59. pmc EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A
    Lei Sun
    Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
    Proc Natl Acad Sci U S A 105:7153-8. 2008
    ..These findings establish Aurora-B as an EB1-interacting protein and suggest that EB1 stimulates Aurora-B activity through antagonizing its dephosphorylation/inactivation by PP2A...
  60. doi The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation
    Jihui Qiu
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Res 20:908-18. 2010
    ..Furthermore, we show that PHF8 interacts with RARalpha and functions as a coactivator for RARalpha. Taken together, our results suggest that histone methylation modulated by PHF8 plays a critical role in neuronal differentiation...
  61. pmc Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply
    Katrine Ask
    Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen, Denmark
    EMBO J 31:2013-23. 2012
    ..This function is compromised by two CDAI mutations that impair complex formation with Asf1, providing insight into the molecular basis for CDAI disease...
  62. pmc Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly
    Jun Ichirou Ohzeki
    Department of Human Genome Research, Laboratory of Cell Engineering, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    EMBO J 31:2391-402. 2012
    ..CENP-A arrays assembled de novo by this mechanism can form human artificial chromosomes (HACs) that are propagated indefinitely in human cells...
  63. ncbi A histone octamer-like structure within TFIID
    A Hoffmann
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York 10021, USA
    Nature 380:356-9. 1996
    ..Together with analyses of native TFIID complexes and accompanying crystallographic studies, the results suggest that there is a histone octamer-like TAF complex within TFIID...
  64. pmc Factor-specific modulation of CREB-binding protein acetyltransferase activity
    V Perissi
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 96:3652-7. 1999
    ....
  65. ncbi Specificity determinants of substrate recognition by the protein kinase DYRK1A
    S Himpel
    Institut fur Pharmakologie und Toxikologie, RWTH Aachen, 52057 Aachen, Germany
    J Biol Chem 275:2431-8. 2000
    ..This marked difference in substrate specificity between DYRK1A and ERK2 can be explained by the requirement for an arginine at the P -3 site of DYRK substrates and its presumed interaction with aspartate 247 conserved in all DYRKs...
  66. pmc The HOX homeodomain proteins block CBP histone acetyltransferase activity
    W F Shen
    Department of Medicine, VA Medical Center and University of California, San Francisco, California 94121, USA
    Mol Cell Biol 21:7509-22. 2001
    ....
  67. pmc Reconstitution of recombinant chromatin establishes a requirement for histone-tail modifications during chromatin assembly and transcription
    A Loyola
    Howard Hughes Medical Institute, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 15:2837-51. 2001
    ..The effects of histone-tail modifications were observed in nuclear extracts. A highly reconstituted RNA polymerase II transcription system was refractory to the effect imposed by acetylation and methylation...
  68. ncbi Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase
    H Wang
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell 8:1207-17. 2001
    ..Thus, our study provides a molecular explanation to the differential effects of H3-K4 and H3-K9 methylation on transcription...
  69. ncbi Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex
    Sang Beom Seo
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:14005-10. 2002
    ....
  70. pmc A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP
    Ann Båvner
    Department of Biosciences at Novum, Karolinska Institutet, S 14157 Huddinge, Sweden
    EMBO Rep 3:478-84. 2002
    ..We suggest histone acetyltransferases and histones as targets for EID1 action and propose that SHP inhibition of transcription involves EID1 antagonism of CBP/p300-dependent coactivator functions...
  71. pmc A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation
    Jiujiu Yu
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6149, USA
    EMBO J 22:3403-10. 2003
    ..This implies that the SMRT HID participates in interpreting the histone code in a feed-forward mechanism that promotes and maintains histone deacetylation at genomic sites of SMRT recruitment...
  72. pmc mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad
    Sharmistha Pal
    Department of Molecular and Cellular Biochemistry, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 23:7475-87. 2003
    ..These results suggest that hSWI/SNF complexes, through their ability to interact with activator and repressor proteins, control expression of genes involved in cell growth and proliferation...
  73. ncbi Identification of chromatin-related protein interactions using protein microarrays
    Matthew A Coleman
    Lawrence Livermore National Laboratory, 7000 East Avenue, L 448, Livermore, CA 94550, USA
    Proteomics 3:2101-7. 2003
    ..This is the first demonstration of an interaction between RAD51B and histone proteins that may be important for the successful repair of DNA double-strand breaks...
  74. ncbi In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail
    Evdokia Pasheva
    Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Biochemistry 43:2935-40. 2004
    ..The alterations in the acetylation pattern of HMGB-1 and -2 upon removal of the C-terminal tail are regarded as a means by which the acidic domain modulates some properties of these proteins...
  75. ncbi Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor
    Todd Macfarlan
    Department of Pharmacology
    J Biol Chem 280:7346-58. 2005
    ....
  76. ncbi CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain
    Jae Hwan Kim
    Department of Biochemistry and Molecular Biology, Cancer Research Institute, Interdisciplinary Program in Genetic Engineering, Seoul National University College of Medicine, Seoul 110 799, Republic of Korea
    Nat Struct Mol Biol 12:423-8. 2005
    ..These results suggest a novel mechanism whereby CtBP1 serves as an energy-sensing repressor of histone acetyltransferase(s) and thus affects general transcription...
  77. ncbi An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
    Min Gyu Lee
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 437:432-5. 2005
    ..Together, these results highlight an essential role for CoREST in demethylation of H3K4 both in vitro and in vivo...
  78. pmc Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription
    V Swaminathan
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Jakkur, Bangalore, India
    Mol Cell Biol 25:7534-45. 2005
    ..These results establish nucleophosmin (NPM1) as a human histone chaperone that becomes acetylated, resulting in the enhancement of chromatin transcription...
  79. ncbi Human histone demethylase LSD1 reads the histone code
    Federico Forneris
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, Pavia 27100, Italy
    J Biol Chem 280:41360-5. 2005
    ..LSD1 is a chromatin-modifying enzyme, which is able to read different epigenetic marks on the histone N-terminal tail and can serve as a docking module for the stabilization of the associated corepressor complex(es) on chromatin...
  80. ncbi Double chromodomains cooperate to recognize the methylated histone H3 tail
    John F Flanagan
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Nature 438:1181-5. 2005
    ..Furthermore, unique inserts within chromodomain 1 of CHD1 block the expected site of H3 tail binding seen in HP1 and Polycomb, instead directing H3 binding to a groove at the inter-chromodomain junction...
  81. ncbi Structural basis for the methylation site specificity of SET7/9
    Jean Francois Couture
    Department of Biological Chemistry, University of Michigan, 1301 Catherine Road, Ann Arbor, Michigan 48109 0606, USA
    Nat Struct Mol Biol 13:140-6. 2006
    ..Among the putative targets is TAF7, which is methylated at Lys5 by the enzyme in vitro. These results demonstrate the predictive value of the consensus motif in identifying novel substrates for SET7/9...
  82. pmc Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein
    Roberta Carbone
    Department of Experimental Oncology, European Institute of Oncology, and Department of Biomolecular Sciences and Biotechnologies, University of Milan, Italy
    Mol Cell Biol 26:1288-96. 2006
    ....
  83. ncbi Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5
    Zhifu Han
    National Institute of Biological Sciences, Beijing 102206, China
    Mol Cell 22:137-44. 2006
    ..Both structural and biochemical studies presented here suggest another mode of recognition for the methylated histone tail...
  84. pmc Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
    Ethan Ford
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 20:1075-80. 2006
    ..Depletion of SIRT7 stops cell proliferation and triggers apoptosis. Our findings suggest that SIRT7 is a positive regulator of Pol I transcription and is required for cell viability in mammals...
  85. ncbi Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells
    Suresh K Rayala
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 281:19092-9. 2006
    ..Together these findings indicate that DLC1-KIBRA interaction is essential for ER transactivation in breast cancer cells...
  86. pmc Aurora-B/AIM-1 regulates the dynamic behavior of HP1alpha at the G2-M transition
    Yasuhiko Terada
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Biol Cell 17:3232-41. 2006
    ..In conclusion, these results showed that Aurora-B/AIM-1 is necessary for regulated histone modifications involved in binding of HP1alpha by the N terminus of histone H3 during mitosis...
  87. ncbi Regulation of histone acetyltransferase activity of p300 and PCAF by proto-oncogene protein DEK
    Soo Il Ko
    Department of Life Science, College of Natural Sciences, Chung Ang University, Seoul 156 756, Republic of Korea
    FEBS Lett 580:3217-22. 2006
    ..Collectively, our data illustrate the important regulatory role played by protein DEK in transcriptional regulation, and suggest that transcription-regulating acidic domain regions may play a role in leukemogenesis...
  88. ncbi Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II
    Rushad Pavri
    Howard Hughes Medical Institute, Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA
    Cell 125:703-17. 2006
    ....
  89. ncbi Molecular recognition of histone H3 by the WD40 protein WDR5
    Jean Francois Couture
    Department of Biological Chemistry, University of Michigan, 1301 Catherine Road, Ann Arbor, Michigan 48109 0606, USA
    Nat Struct Mol Biol 13:698-703. 2006
    ....
  90. pmc Structural basis for molecular recognition and presentation of histone H3 by WDR5
    Anja Schuetz
    Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
    EMBO J 25:4245-52. 2006
    ..We propose a mechanism for the involvement of WDR5 in binding and presenting histone H3K4 for further methylation as a component of MLL complexes...
  91. pmc Crystal structure of human histone lysine-specific demethylase 1 (LSD1)
    Yong Chen
    Department of Biological Chemistry, University of Michigan Medical School, 5413 Medical Science I, 1301 Catherine Road, Ann Arbor, MI 48109 0606, USA
    Proc Natl Acad Sci U S A 103:13956-61. 2006
    ..These results provide a framework for further probing the catalytic mechanism and the functional roles of LSD1...
  92. pmc The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation
    Petar Jelinic
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    PLoS Biol 4:e355. 2006
    ..These results suggest that CTCFL and PRMT7 may play a role in male germline imprinted gene methylation...
  93. pmc Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3
    Shumin Wu
    University of Southern California Keck School of Medicine, Department of Biochemistry and Molecular Biology, Los Angeles, CA 90033, USA
    FEBS Lett 581:3289-96. 2007
    ..These findings indicate that the tandem MBT repeats form a functional structure required for biological activity of hSFMBT and predict similar properties for other MBT domain-containing proteins...
  94. pmc Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes
    Gregory D Gregory
    Children s Hospital of Philadelphia, Division of Hematology, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 27:8466-79. 2007
    ..Collectively, our data suggest that ASH1L occupies most, if not all, active genes and methylates histone H3 in a nonredundant fashion at a subset of genes...
  95. pmc Identification of distinct SET/TAF-Ibeta domains required for core histone binding and quantitative characterisation of the interaction
    Zoe Karetsou
    Laboratory of Biological Chemistry, Medical School, University of Ioannina, 451 10 Ioannina, Greece
    BMC Biochem 10:10. 2009
    ....
  96. pmc Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications
    Catherine A Musselman
    Department of Pharmacology, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Biochem J 423:179-87. 2009
    ..Together our findings suggest that the PHD2 finger plays a role in targeting of the CHD4/NuRD complex to chromatin...
  97. pmc Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression
    Marc Lavigne
    Institut Pasteur, Departement de Biologie du Developpement, Unité de Recherche Associée URA2578 du Centre National de la Recherche Scientifique CNRS, Unité de Régulation Epigénétique, équipe AVENIR de l Institut National de la Santé Et de la Recherche Médicale INSERM, Paris, France
    PLoS Genet 5:e1000769. 2009
    ..Altogether, our data suggest that HP1 chromoshadow-domains can benefit from the opening of nucleosomal structures to bind chromatin and that HP1 proteins use this property to detect and arrest unwanted chromatin remodeling...
  98. doi The dimeric structure and the bivalent recognition of H3K4me3 by the tumor suppressor ING4 suggests a mechanism for enhanced targeting of the HBO1 complex to chromatin
    Alicia Palacios
    CIC bioGUNE, Structural Biology Unit, Parque Tecnologico de Bizkaia, 48160 Derio, Spain
    J Mol Biol 396:1117-27. 2010
    ..This mechanism could be common to other ING-containing remodeling complexes...
  99. pmc Structural biology of human H3K9 methyltransferases
    Hong Wu
    Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e8570. 2010
    ..We also propose a model where long-range electrostatics bring enzyme and histone substrate together, while the presence of an arginine upstream of the target lysine is critical for binding and specificity...
  100. pmc G9a and Glp methylate lysine 373 in the tumor suppressor p53
    Jing Huang
    Laboratory of Cancer Biology and Genetics, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:9636-41. 2010
    ..These data reveal a new methylation site within p53 mediated by the methylases G9a and Glp and indicate that G9a is a potential inhibitory target for cancer treatment...
  101. pmc Nucleosome formation activity of human somatic nuclear autoantigenic sperm protein (sNASP)
    Akihisa Osakabe
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku ku, Tokyo 162 8480, Japan
    J Biol Chem 285:11913-21. 2010
    ..These experiments are the first demonstration that human NASP directly promotes nucleosome assembly and provide compelling evidence that sNASP is a bona fide histone chaperone for H3.H4...