Genomes and Genes
Gene Symbol: HIST1H2BG
Description: histone cluster 1 H2B family member g
Alias: H2B.1A, H2B/a, H2BFA, dJ221C16.8, histone H2B type 1-C/E/F/G/I, H2B histone family, member A, histone 1, H2bg, histone H2B.1 A, histone H2B.a, histone cluster 1, H2bg
- FOXM1c transactivates the human c-myc promoter directly via the two TATA boxes P1 and P2Inken Wierstra
Institute of Molecular Biology, Medical School Hannover, Germany
FEBS J 273:4645-67. 2006..Accordingly, dominant-negative FOXM1c proteins reduced cell growth approximately threefold, demonstrating a proliferation-stimulating function for wild-type FOXM1c...
- Identification and validation of candidate epigenetic biomarkers in lung adenocarcinomaIben Daugaard
Department of Biomedicine, Aarhus University, Bartholins Alle 6, DK 8000 Aarhus C, Denmark
Sci Rep 6:35807. 2016..In conclusion, this study has identified and validated 15 DMRs that can be targeted as biomarkers in LAC...
- Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinomaLinda Rieswijk
Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands Netherlands Toxicogenomics Centre NTC, 6229 ER Maastricht, The Netherlands Electronic address
Toxicology 350:31-9. 2016..This study is the first to report on a carcinogen-induced persistent impact on the epigenetic footprint in relation with the transcriptome which could be indicative for the early onset of AFB1-related development of HCC. ..
- Gene expression profiling analysis contributes to understanding the association between non-syndromic cleft lip and palate, and cancerHongyi Wang
Department of Plastic Surgery, General Hospital of Shenyang Military Area Command, PLA, Shenyang, Liaoning 110016, P R China
Mol Med Rep 13:2110-6. 2016..The TP53, CDK1, SMAD3, PIK3R1 and CASP3 genes were found to be associated, not only with NSCL/P, but also with cancer. These results may contribute to a better understanding of the molecular mechanisms of NSCL/P...
- The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2BMélanie Bonizec
Sorbonne Paris Cité, INSERM UMR944, CNRS UMR7212, Equipe Labellisée Ligue contre le Cancer, University of Paris Diderot, Hopital St Louis 1, Avenue Claude Vellefaux 75475 Paris cedex 10, France
Nucleic Acids Res 42:10975-86. 2014..Together, these results suggest a prominent role of Cdc48/p97 in the coordination of chromatin remodeling with gene transcription to define cellular differentiation processes. ..
- Tumor Necrosis Factor Receptor Associated Factors (TRAFs) 2 and 3 Form a Transcriptional Complex with Phosho-RNA Polymerase II and p65 in CD40 Ligand Activated Neuro2a CellsJimmy El Hokayem
Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA
Mol Neurobiol . 2016..Our findings demonstrate for the first time that TRAFs 2/3 participate in the formation of a CD40L-induced transcriptional complex in neuronal cells...
- Chromatin modification and NBS1: their relationship in DNA double-strand break repairYuichiro Saito
Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University
Genes Genet Syst 90:195-208. 2016....
- Thermodynamic studies of U(VI) complexation with glutardiamidoxime for sequestration of uranium from seawaterGuoxin Tian
Chemical Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, California 94720, USA
Dalton Trans 42:5690-6. 2013..The competition between glutardiamidoxime and carbonate for complexing U(VI) in 3% NaCl was also studied in comparison with the cyclic glutarimidedioxime ligand (H2A) previously studied...
- UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cellsJee Young An
Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 7:e37414. 2012..Thus, UBR2, known as the recognition component of a major cellular proteolytic system, is associated with chromatin and controls chromatin dynamics and gene expression in both germ cells and somatic cells...
- Transcriptome study of differential expression in schizophreniaAlan R Sanders
Department of Psychiatry and Behavioral Sciences, NorthShore University Healthsystem, Evanston, IL 60201, USA
Hum Mol Genet 22:5001-14. 2013..expression of extended major histocompatibility complex (xMHC) region histones (HIST1H2BD, HIST1H2BC, HIST1H2BH, HIST1H2BG and HIST1H4K) converges with the genetic evidence from GWAS, which find the xMHC to be the most significant ..
- Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79Huck Hui Ng
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:34655-7. 2002..Our study provides a new example of trans-histone regulation between modifications on different histones. In addition, it suggests that Rad6 affects telomeric silencing, at least in part, by influencing methylation of histone H3...
- Array analysis for potential biomarker of gemcitabine identification in non-small cell lung cancer cell linesHai Hong Zhang
Department of Rheumatism and Immunology, First Clinical Medical College affiliated to Harbin Medical University Harbin, China
Int J Clin Exp Pathol 6:1734-46. 2013..Our results might provide potential biomarkers for gemcitabine sensitivity prediction and putative targets to overcome gemcitabine resistance in NSCLC patients. ..
- Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase IIRushad Pavri
Howard Hughes Medical Institute, Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA
Cell 125:703-17. 2006....
- Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaksLilach Moyal
The David and Inez Myers Laboratory for Genetic Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Mol Cell 41:529-42. 2011..Our data and previous data suggest a two-stage model for chromatin decondensation that facilitates DSB repair...
- Glucose metabolism induces mono-ubiquitination of histone H2B in mammalian cellsZhen Gao
Department of Drug Development, Nevada Cancer Institute, 1 Breakthrough Way, Las Vegas, NV 89135, USA
Biochem Biophys Res Commun 404:428-33. 2011....
- Phosphatidylserine as an anchor for plasminogen and its plasminogen receptor, histone H2B, to the macrophage surfaceR Das
Department of Molecular Cardiology, Cleveland Clinic, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland, OH 44195, USA
J Thromb Haemost 9:339-49. 2011..Histone H2B (H2B) acts as a Plg-R and its cell surface expression is up-regulated when monocytes are differentiated to macrophages via a pathway dependent on L-type Ca(2+) channels and intracellular Ca(2+)...
- The cap binding complex influences H2B ubiquitination by facilitating splicing of the SUS1 pre-mRNAMunshi Azad Hossain
Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
RNA 15:1515-27. 2009....
- Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylationRobert K McGinty
Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, New York 10065, USA
Nature 453:812-6. 2008..This work demonstrates a direct biochemical crosstalk between two modifications on separate histone proteins within a nucleosome...
- Phosphorylation by casein kinase 2 regulates Nap1 localization and functionMeredith E K Calvert
Center for Cell Signaling, University of Virginia, Box 800577 HSC, Charlottesville, VA 22908, USA
Mol Cell Biol 28:1313-25. 2008..In conclusion, our data show that Nap1 phosphorylation by CK2 appears to regulate Nap1 localization and is required for normal progression through S phase...
- FOXM1, a typical proliferation-associated transcription factorInken Wierstra
Wissmannstr 17, D 30173 Hannover, Germany
Biol Chem 388:1257-74. 2007....
- Identification of differentially expressed genes after PPM1D silencing in breast cancerJenita Pärssinen
Laboratory of Cancer Genetics, Tampere University Hospital, FI 33014 University of Tampere, Finland
Cancer Lett 259:61-70. 2008..Overall, our findings suggest that PPM1D contributes to breast cancer associated phenotypic characteristics by directly or indirectly affecting several important cellular signaling pathways...
- Analysis of viral cis elements conferring Kaposi's sarcoma-associated herpesvirus episome partitioning and maintenanceRebecca L Skalsky
Department of Molecular Genetics and Microbiology, and Shands Cancer Center, University of Florida, 1613 Mowry Road, Gainesville, FL 32610 3633, USA
J Virol 81:9825-37. 2007..Our data suggest that the efficiency with which KSHV establishes latency is dependent on multiple LANA activities, which stabilize viral genomes early after de novo infection...
- Identification of chromatin-related protein interactions using protein microarraysMatthew A Coleman
Lawrence Livermore National Laboratory, 7000 East Avenue, L 448, Livermore, CA 94550, USA
Proteomics 3:2101-7. 2003..This is the first demonstration of an interaction between RAD51B and histone proteins that may be important for the successful repair of DNA double-strand breaks...
- Isolation and characterization of two human H1 histone genes within clusters of core histone genesW Albig
Institut fur Biochemie, Universitat Gottingen, Federal Republic of Germany
Genomics 10:940-8. 1991..In continuation of our previous analysis of two human H1 genes, this analysis raises the number of completely sequenced H1 histone genes within clusters of core histone genes to four...
- Biochemical and antibacterial analysis of human wound and blister fluidM Frohm
Department of Microbiology, Stockholm University, Sweden
Eur J Biochem 237:86-92. 1996..It is concluded that analysis of wound fluid yields peptide and activity patterns with novel fragments of important peptides, and quantitative differences, that can be useful to understand molecular mechanisms of wound healing further...
- Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assayC Díaz-Jullien
Departamento de Bioquimica y Biologia Molecular, Facultad de Biologia, Universidad de Santiago, Spain
Biochim Biophys Acta 1296:219-27. 1996..We discuss the possibility that Pro T alpha plays a role in chromatin remodelling...
- Identification of stage-regulated and differentiation-enriched transcripts during transformation of the African trypanosome from its bloodstream to procyclic formK R Matthews
University of Manchester, UK
Mol Biochem Parasitol 95:81-95. 1998....
- Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosisL Piredda
Department of Biology, University of Rome Tor Vergata Rome, Italy
FASEB J 13:355-64. 1999..By contrast, the tTG-beta-tubulin interaction does not result in the cross-linking of this cytoskeletal protein, which suggests that microtubules act as the anchorage site for tTG and GST P1-1 interaction...
- Molecular and structural properties of three autoimmune IgG monoclonal antibodies to histone H2BM Monestier
Department of Microbiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
J Biol Chem 275:13558-63. 2000..The study of the interaction between self-antigens and spontaneously occurring autoantibodies may help us elucidate the mechanisms driving the expansion of self-reactive lymphocytes...
- Endotoxin-neutralizing antimicrobial proteins of the human placentaHun Sik Kim
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong gu, Taejon 305 701, Korea
J Immunol 168:2356-64. 2002..Our studies suggest that histones H2A and H2B may endow the epithelium of the placenta with an antimicrobial and endotoxin-neutralizing barrier against microorganisms that invade this immune-privileged site...
- Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinaseWang L Cheung
Department of Microbiology, University of Virginia Health System, Charlottesville 22908, USA
Cell 113:507-17. 2003..Our data provide evidence for a potential apoptotic "histone code."..
- Antimicrobial peptides in the first line defence of human colon mucosaMaria Tollin
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Peptides 24:523-30. 2003..Combined, these results indicate that the colon mucosa is protected by a complex mixture of polypeptides, able to kill invading microbes and working in synergy as a barrier against bacterial invasion...
- Antimicrobial polypeptides of the human colonic epitheliumScott J Howell
The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Peptides 24:1763-70. 2003..These polypeptides normally reside inside cells and are proposed to contribute to the formation of the functional antimicrobial barrier of the colonic epithelium...
- Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2BGlen W Young
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
J Biol Chem 280:26094-8. 2005..Because PIMT has numerous substrates in cells, these findings also suggest that D-aspartate may be more common in cellular proteins than hitherto imagined and that its occurrence, in some proteins at least, is independent of animal age...
- Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometryMeftun Ahmed
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
J Proteome Res 4:931-40. 2005....
- Inhibition of core histones acetylation by carcinogenic nickel(II)Filip Golebiowski
Laboratory of Comparative Carcinogenesis, NCI at Frederick, Frederick, MD, 21702 1201, USA
Mol Cell Biochem 279:133-9. 2005..The observed effects may contribute to neoplastic transformation of Ni(II)-exposed cells...
- Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulationBing Zhu
Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 683 Hoes Lane, Piscataway, New Jersey 08854, USA
Mol Cell 20:601-11. 2005..In contrast, RNAi against the RNF20/40 complex or hPAF complex reduces H2B monoubiquitination, lowers methylation levels at H3 lysines 4 and 79, and represses HOX gene expression...
- Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometryDebora Bonenfant
Genome and Proteome Sciences, Novartis Institutes for BioMedical Research, CH 4056 Basel, Switzerland
Mol Cell Proteomics 5:541-52. 2006..The analysis of core histone subtypes with their modifications provides a first step toward an understanding of the functional significance of the diversity of histone structures...
- Gene-specific characterization of human histone H2B by electron capture dissociationNertila Siuti
Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
J Proteome Res 5:233-9. 2006..Modest hyperacetylation of H2B family members was observed after sodium butyrate treatment...
- Quantitative proteomic analysis of post-translational modifications of human histonesHans Christian Beck
Danish Technological Institute, Holbergsvej 10, DK 6000 Kolding, Denmark
Mol Cell Proteomics 5:1314-25. 2006..This demonstrates that mass spectrometry-based quantitative proteomic analysis of post-translational modifications is a viable approach for functional analysis of candidate drugs, such as HDAC inhibitors...
- Human spleen histone H2B. Isolation and amino acid sequenceY Ohe
J Biochem 85:615-24. 1979..Thus, it is concluded that the H2B sequence of lower mammals was conserved during the evolutionary process leading to man...