HIST1H2BG

Summary

Gene Symbol: HIST1H2BG
Description: histone cluster 1 H2B family member g
Alias: H2B.1A, H2B/a, H2BFA, dJ221C16.8, histone H2B type 1-C/E/F/G/I, H2B histone family, member A, histone 1, H2bg, histone H2B.1 A, histone H2B.a, histone cluster 1, H2bg
Species: human

Top Publications

  1. ncbi FOXM1c transactivates the human c-myc promoter directly via the two TATA boxes P1 and P2
    Inken Wierstra
    Institute of Molecular Biology, Medical School Hannover, Germany
    FEBS J 273:4645-67. 2006
  2. pmc Identification and validation of candidate epigenetic biomarkers in lung adenocarcinoma
    Iben Daugaard
    Department of Biomedicine, Aarhus University, Bartholins Alle 6, DK 8000 Aarhus C, Denmark
    Sci Rep 6:35807. 2016
  3. doi Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma
    Linda Rieswijk
    Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands Netherlands Toxicogenomics Centre NTC, 6229 ER Maastricht, The Netherlands Electronic address
    Toxicology 350:31-9. 2016
  4. pmc Gene expression profiling analysis contributes to understanding the association between non-syndromic cleft lip and palate, and cancer
    Hongyi Wang
    Department of Plastic Surgery, General Hospital of Shenyang Military Area Command, PLA, Shenyang, Liaoning 110016, P R China
    Mol Med Rep 13:2110-6. 2016
  5. pmc The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B
    Mélanie Bonizec
    Sorbonne Paris Cité, INSERM UMR944, CNRS UMR7212, Equipe Labellisée Ligue contre le Cancer, University of Paris Diderot, Hopital St Louis 1, Avenue Claude Vellefaux 75475 Paris cedex 10, France
    Nucleic Acids Res 42:10975-86. 2014
  6. pmc Tumor Necrosis Factor Receptor Associated Factors (TRAFs) 2 and 3 Form a Transcriptional Complex with Phosho-RNA Polymerase II and p65 in CD40 Ligand Activated Neuro2a Cells
    Jimmy El Hokayem
    Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA
    Mol Neurobiol . 2016
  7. doi Chromatin modification and NBS1: their relationship in DNA double-strand break repair
    Yuichiro Saito
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University
    Genes Genet Syst 90:195-208. 2016
  8. doi Thermodynamic studies of U(VI) complexation with glutardiamidoxime for sequestration of uranium from seawater
    Guoxin Tian
    Chemical Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, California 94720, USA
    Dalton Trans 42:5690-6. 2013
  9. pmc UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells
    Jee Young An
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e37414. 2012
  10. pmc Transcriptome study of differential expression in schizophrenia
    Alan R Sanders
    Department of Psychiatry and Behavioral Sciences, NorthShore University Healthsystem, Evanston, IL 60201, USA
    Hum Mol Genet 22:5001-14. 2013

Scientific Experts

  • Inken Wierstra
  • Linda Rieswijk
  • K R Matthews
  • Filip Golebiowski
  • Meftun Ahmed
  • Hongyi Wang
  • Jimmy El Hokayem
  • Iben Daugaard
  • Yuichiro Saito
  • Mélanie Bonizec
  • Hai Hong Zhang
  • Guoxin Tian
  • Bing Zhu
  • Alan R Sanders
  • Jee Young An
  • Lilach Moyal
  • Zhen Gao
  • R Das
  • Munshi Azad Hossain
  • Robert K McGinty
  • Jenita Pärssinen
  • Meredith E K Calvert
  • Rebecca L Skalsky
  • Debora Bonenfant
  • Hans Christian Beck
  • Nertila Siuti
  • Rushad Pavri
  • Danny Reinberg
  • Glen W Young
  • Craig A Mizzen
  • Jiulong Liang
  • Wang L Cheung
  • Hui Zhou
  • Matthew A Coleman
  • Scott J Howell
  • Lise Lotte Hansen
  • Yang Wang
  • Tomasz K Wojdacz
  • Qian Zhang
  • Diana Dominguez
  • Jie Shi
  • Maria Tollin
  • John R Bethea
  • Tina E Kjeldsen
  • Lasse S Kristensen
  • Yu Zhang
  • Kai Tao
  • Liangliang Quan
  • Henrik Hager
  • Tao Qiu
  • George C Brittain
  • Zafar Nawaz
  • Junya Kobayashi
  • Catherine Dargemont
  • Sabine Wenzel
  • Hun Sik Kim
  • Wojciech Pokrzywa
  • Lucas Hérissant
  • Huck Hui Ng
  • Fuqiang Geng
  • Sabine Krause
  • Paco Rodriguez
  • William P Tansey
  • Thorsten Hoppe
  • Gregory C Howard
  • Jubao Duan
  • Yi Fang Mei
  • Harald H H Goring
  • Eugene I Drigalenko
  • Jianxin Shi
  • Chun Li Che
  • Deli He
  • Yu zhi Shi
  • Linfeng Rao
  • Jessica Freda
  • Simon J Teat
  • Zhi Yi Zhang
  • Winton Moy
  • Pablo V Gejman
  • Jai Wha Seo
  • Min Jae Lee
  • Yong Jun Lee
  • Tae You Kim
  • Adriana Zakrzewska
  • Bo Yeon Kim
  • Young Dong Yoo
  • Dirk G de Rooij
  • Jun Min Jang
  • Euna Kim
  • Yong Tae Kwon

Detail Information

Publications41

  1. ncbi FOXM1c transactivates the human c-myc promoter directly via the two TATA boxes P1 and P2
    Inken Wierstra
    Institute of Molecular Biology, Medical School Hannover, Germany
    FEBS J 273:4645-67. 2006
    ..Accordingly, dominant-negative FOXM1c proteins reduced cell growth approximately threefold, demonstrating a proliferation-stimulating function for wild-type FOXM1c...
  2. pmc Identification and validation of candidate epigenetic biomarkers in lung adenocarcinoma
    Iben Daugaard
    Department of Biomedicine, Aarhus University, Bartholins Alle 6, DK 8000 Aarhus C, Denmark
    Sci Rep 6:35807. 2016
    ..In conclusion, this study has identified and validated 15 DMRs that can be targeted as biomarkers in LAC...
  3. doi Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma
    Linda Rieswijk
    Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands Netherlands Toxicogenomics Centre NTC, 6229 ER Maastricht, The Netherlands Electronic address
    Toxicology 350:31-9. 2016
    ..This study is the first to report on a carcinogen-induced persistent impact on the epigenetic footprint in relation with the transcriptome which could be indicative for the early onset of AFB1-related development of HCC. ..
  4. pmc Gene expression profiling analysis contributes to understanding the association between non-syndromic cleft lip and palate, and cancer
    Hongyi Wang
    Department of Plastic Surgery, General Hospital of Shenyang Military Area Command, PLA, Shenyang, Liaoning 110016, P R China
    Mol Med Rep 13:2110-6. 2016
    ..The TP53, CDK1, SMAD3, PIK3R1 and CASP3 genes were found to be associated, not only with NSCL/P, but also with cancer. These results may contribute to a better understanding of the molecular mechanisms of NSCL/P...
  5. pmc The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B
    Mélanie Bonizec
    Sorbonne Paris Cité, INSERM UMR944, CNRS UMR7212, Equipe Labellisée Ligue contre le Cancer, University of Paris Diderot, Hopital St Louis 1, Avenue Claude Vellefaux 75475 Paris cedex 10, France
    Nucleic Acids Res 42:10975-86. 2014
    ..Together, these results suggest a prominent role of Cdc48/p97 in the coordination of chromatin remodeling with gene transcription to define cellular differentiation processes. ..
  6. pmc Tumor Necrosis Factor Receptor Associated Factors (TRAFs) 2 and 3 Form a Transcriptional Complex with Phosho-RNA Polymerase II and p65 in CD40 Ligand Activated Neuro2a Cells
    Jimmy El Hokayem
    Department of Biochemistry and Molecular Biology, University of Miami, Miller School of Medicine, Miami, FL, USA
    Mol Neurobiol . 2016
    ..Our findings demonstrate for the first time that TRAFs 2/3 participate in the formation of a CD40L-induced transcriptional complex in neuronal cells...
  7. doi Chromatin modification and NBS1: their relationship in DNA double-strand break repair
    Yuichiro Saito
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University
    Genes Genet Syst 90:195-208. 2016
    ....
  8. doi Thermodynamic studies of U(VI) complexation with glutardiamidoxime for sequestration of uranium from seawater
    Guoxin Tian
    Chemical Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, California 94720, USA
    Dalton Trans 42:5690-6. 2013
    ..The competition between glutardiamidoxime and carbonate for complexing U(VI) in 3% NaCl was also studied in comparison with the cyclic glutarimidedioxime ligand (H2A) previously studied...
  9. pmc UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells
    Jee Young An
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e37414. 2012
    ..Thus, UBR2, known as the recognition component of a major cellular proteolytic system, is associated with chromatin and controls chromatin dynamics and gene expression in both germ cells and somatic cells...
  10. pmc Transcriptome study of differential expression in schizophrenia
    Alan R Sanders
    Department of Psychiatry and Behavioral Sciences, NorthShore University Healthsystem, Evanston, IL 60201, USA
    Hum Mol Genet 22:5001-14. 2013
    ..expression of extended major histocompatibility complex (xMHC) region histones (HIST1H2BD, HIST1H2BC, HIST1H2BH, HIST1H2BG and HIST1H4K) converges with the genetic evidence from GWAS, which find the xMHC to be the most significant ..
  11. ncbi Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79
    Huck Hui Ng
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:34655-7. 2002
    ..Our study provides a new example of trans-histone regulation between modifications on different histones. In addition, it suggests that Rad6 affects telomeric silencing, at least in part, by influencing methylation of histone H3...
  12. pmc Array analysis for potential biomarker of gemcitabine identification in non-small cell lung cancer cell lines
    Hai Hong Zhang
    Department of Rheumatism and Immunology, First Clinical Medical College affiliated to Harbin Medical University Harbin, China
    Int J Clin Exp Pathol 6:1734-46. 2013
    ..Our results might provide potential biomarkers for gemcitabine sensitivity prediction and putative targets to overcome gemcitabine resistance in NSCLC patients. ..
  13. ncbi Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II
    Rushad Pavri
    Howard Hughes Medical Institute, Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA
    Cell 125:703-17. 2006
    ....
  14. pmc Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks
    Lilach Moyal
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell 41:529-42. 2011
    ..Our data and previous data suggest a two-stage model for chromatin decondensation that facilitates DSB repair...
  15. doi Glucose metabolism induces mono-ubiquitination of histone H2B in mammalian cells
    Zhen Gao
    Department of Drug Development, Nevada Cancer Institute, 1 Breakthrough Way, Las Vegas, NV 89135, USA
    Biochem Biophys Res Commun 404:428-33. 2011
    ....
  16. pmc Phosphatidylserine as an anchor for plasminogen and its plasminogen receptor, histone H2B, to the macrophage surface
    R Das
    Department of Molecular Cardiology, Cleveland Clinic, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland, OH 44195, USA
    J Thromb Haemost 9:339-49. 2011
    ..Histone H2B (H2B) acts as a Plg-R and its cell surface expression is up-regulated when monocytes are differentiated to macrophages via a pathway dependent on L-type Ca(2+) channels and intracellular Ca(2+)...
  17. pmc The cap binding complex influences H2B ubiquitination by facilitating splicing of the SUS1 pre-mRNA
    Munshi Azad Hossain
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
    RNA 15:1515-27. 2009
    ....
  18. pmc Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation
    Robert K McGinty
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York, New York 10065, USA
    Nature 453:812-6. 2008
    ..This work demonstrates a direct biochemical crosstalk between two modifications on separate histone proteins within a nucleosome...
  19. pmc Phosphorylation by casein kinase 2 regulates Nap1 localization and function
    Meredith E K Calvert
    Center for Cell Signaling, University of Virginia, Box 800577 HSC, Charlottesville, VA 22908, USA
    Mol Cell Biol 28:1313-25. 2008
    ..In conclusion, our data show that Nap1 phosphorylation by CK2 appears to regulate Nap1 localization and is required for normal progression through S phase...
  20. ncbi FOXM1, a typical proliferation-associated transcription factor
    Inken Wierstra
    Wissmannstr 17, D 30173 Hannover, Germany
    Biol Chem 388:1257-74. 2007
    ....
  21. ncbi Identification of differentially expressed genes after PPM1D silencing in breast cancer
    Jenita Pärssinen
    Laboratory of Cancer Genetics, Tampere University Hospital, FI 33014 University of Tampere, Finland
    Cancer Lett 259:61-70. 2008
    ..Overall, our findings suggest that PPM1D contributes to breast cancer associated phenotypic characteristics by directly or indirectly affecting several important cellular signaling pathways...
  22. pmc Analysis of viral cis elements conferring Kaposi's sarcoma-associated herpesvirus episome partitioning and maintenance
    Rebecca L Skalsky
    Department of Molecular Genetics and Microbiology, and Shands Cancer Center, University of Florida, 1613 Mowry Road, Gainesville, FL 32610 3633, USA
    J Virol 81:9825-37. 2007
    ..Our data suggest that the efficiency with which KSHV establishes latency is dependent on multiple LANA activities, which stabilize viral genomes early after de novo infection...
  23. ncbi Identification of chromatin-related protein interactions using protein microarrays
    Matthew A Coleman
    Lawrence Livermore National Laboratory, 7000 East Avenue, L 448, Livermore, CA 94550, USA
    Proteomics 3:2101-7. 2003
    ..This is the first demonstration of an interaction between RAD51B and histone proteins that may be important for the successful repair of DNA double-strand breaks...
  24. ncbi Isolation and characterization of two human H1 histone genes within clusters of core histone genes
    W Albig
    Institut fur Biochemie, Universitat Gottingen, Federal Republic of Germany
    Genomics 10:940-8. 1991
    ..In continuation of our previous analysis of two human H1 genes, this analysis raises the number of completely sequenced H1 histone genes within clusters of core histone genes to four...
  25. ncbi Biochemical and antibacterial analysis of human wound and blister fluid
    M Frohm
    Department of Microbiology, Stockholm University, Sweden
    Eur J Biochem 237:86-92. 1996
    ..It is concluded that analysis of wound fluid yields peptide and activity patterns with novel fragments of important peptides, and quantitative differences, that can be useful to understand molecular mechanisms of wound healing further...
  26. ncbi Prothymosin alpha binds histones in vitro and shows activity in nucleosome assembly assay
    C Díaz-Jullien
    Departamento de Bioquimica y Biologia Molecular, Facultad de Biologia, Universidad de Santiago, Spain
    Biochim Biophys Acta 1296:219-27. 1996
    ..We discuss the possibility that Pro T alpha plays a role in chromatin remodelling...
  27. ncbi Identification of stage-regulated and differentiation-enriched transcripts during transformation of the African trypanosome from its bloodstream to procyclic form
    K R Matthews
    University of Manchester, UK
    Mol Biochem Parasitol 95:81-95. 1998
    ....
  28. ncbi Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis
    L Piredda
    Department of Biology, University of Rome Tor Vergata Rome, Italy
    FASEB J 13:355-64. 1999
    ..By contrast, the tTG-beta-tubulin interaction does not result in the cross-linking of this cytoskeletal protein, which suggests that microtubules act as the anchorage site for tTG and GST P1-1 interaction...
  29. ncbi Molecular and structural properties of three autoimmune IgG monoclonal antibodies to histone H2B
    M Monestier
    Department of Microbiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 275:13558-63. 2000
    ..The study of the interaction between self-antigens and spontaneously occurring autoantibodies may help us elucidate the mechanisms driving the expansion of self-reactive lymphocytes...
  30. ncbi Endotoxin-neutralizing antimicrobial proteins of the human placenta
    Hun Sik Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong gu, Taejon 305 701, Korea
    J Immunol 168:2356-64. 2002
    ..Our studies suggest that histones H2A and H2B may endow the epithelium of the placenta with an antimicrobial and endotoxin-neutralizing barrier against microorganisms that invade this immune-privileged site...
  31. ncbi Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase
    Wang L Cheung
    Department of Microbiology, University of Virginia Health System, Charlottesville 22908, USA
    Cell 113:507-17. 2003
    ..Our data provide evidence for a potential apoptotic "histone code."..
  32. ncbi Antimicrobial peptides in the first line defence of human colon mucosa
    Maria Tollin
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Peptides 24:523-30. 2003
    ..Combined, these results indicate that the colon mucosa is protected by a complex mixture of polypeptides, able to kill invading microbes and working in synergy as a barrier against bacterial invasion...
  33. ncbi Antimicrobial polypeptides of the human colonic epithelium
    Scott J Howell
    The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Peptides 24:1763-70. 2003
    ..These polypeptides normally reside inside cells and are proposed to contribute to the formation of the functional antimicrobial barrier of the colonic epithelium...
  34. ncbi Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B
    Glen W Young
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 280:26094-8. 2005
    ..Because PIMT has numerous substrates in cells, these findings also suggest that D-aspartate may be more common in cellular proteins than hitherto imagined and that its occurrence, in some proteins at least, is independent of animal age...
  35. ncbi Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry
    Meftun Ahmed
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    J Proteome Res 4:931-40. 2005
    ....
  36. ncbi Inhibition of core histones acetylation by carcinogenic nickel(II)
    Filip Golebiowski
    Laboratory of Comparative Carcinogenesis, NCI at Frederick, Frederick, MD, 21702 1201, USA
    Mol Cell Biochem 279:133-9. 2005
    ..The observed effects may contribute to neoplastic transformation of Ni(II)-exposed cells...
  37. ncbi Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation
    Bing Zhu
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 683 Hoes Lane, Piscataway, New Jersey 08854, USA
    Mol Cell 20:601-11. 2005
    ..In contrast, RNAi against the RNF20/40 complex or hPAF complex reduces H2B monoubiquitination, lowers methylation levels at H3 lysines 4 and 79, and represses HOX gene expression...
  38. ncbi Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry
    Debora Bonenfant
    Genome and Proteome Sciences, Novartis Institutes for BioMedical Research, CH 4056 Basel, Switzerland
    Mol Cell Proteomics 5:541-52. 2006
    ..The analysis of core histone subtypes with their modifications provides a first step toward an understanding of the functional significance of the diversity of histone structures...
  39. ncbi Gene-specific characterization of human histone H2B by electron capture dissociation
    Nertila Siuti
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Proteome Res 5:233-9. 2006
    ..Modest hyperacetylation of H2B family members was observed after sodium butyrate treatment...
  40. ncbi Quantitative proteomic analysis of post-translational modifications of human histones
    Hans Christian Beck
    Danish Technological Institute, Holbergsvej 10, DK 6000 Kolding, Denmark
    Mol Cell Proteomics 5:1314-25. 2006
    ..This demonstrates that mass spectrometry-based quantitative proteomic analysis of post-translational modifications is a viable approach for functional analysis of candidate drugs, such as HDAC inhibitors...
  41. ncbi Human spleen histone H2B. Isolation and amino acid sequence
    Y Ohe
    J Biochem 85:615-24. 1979
    ..Thus, it is concluded that the H2B sequence of lower mammals was conserved during the evolutionary process leading to man...