HIST1H2AL

Summary

Gene Symbol: HIST1H2AL
Description: histone cluster 1 H2A family member l
Alias: H2A.i, H2A/i, H2AFI, dJ193B12.9, histone H2A type 1, H2A histone family, member I, H2A.1, histone 1, H2al, histone cluster 1, H2al
Species: human

Top Publications

  1. pmc Selection of reference genes for quantitative real-time PCR in equine in vivo and fresh and frozen-thawed in vitro blastocysts
    Katrien Smits
    Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium
    BMC Res Notes 2:246. 2009
  2. ncbi Precise characterization of human histones in the H2A gene family by top down mass spectrometry
    Michael T Boyne
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Proteome Res 5:248-53. 2006
  3. ncbi Human USP3 is a chromatin modifier required for S phase progression and genome stability
    Francesco Nicassio
    IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Curr Biol 17:1972-7. 2007
  4. pmc Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket
    Lucie Roussel
    CNRS, IPBS Institute of Pharmacology and Structural Biology, 205 route de Narbonne, F 31077 Toulouse, France
    EMBO Rep 9:1006-12. 2008
  5. pmc Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase
    Wanil Kim
    Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang 790 784, Republic of Korea
    J Biol Chem 287:5278-89. 2012
  6. pmc Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain
    Mulu Y Lubula
    Department of Pharmaceutical Science, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, USA
    FEBS Lett 588:3844-54. 2014
  7. pmc Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano
    Magda Grudniewska
    European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    elife 5:. 2016
  8. ncbi Definition of a C-reactive protein binding determinant on histones
    T W Du Clos
    Veterans Administration Medical Center, Albuquerque, New Mexico 87108
    J Biol Chem 266:2167-71. 1991
  9. ncbi Presence of particular transcription regulatory elements in the 5'-intergenic region shared by the chicken H2A-III and H2B-V pair
    T Ohshige
    Department of Biochemistry, Miyazaki Medical College, Japan
    Gene 131:193-9. 1993
  10. ncbi Characterization of the H1.5 gene completes the set of human H1 subtype genes
    W Albig
    Institut fur Biochemie und Molekulare Zellbiologie, Universitaet Goettingen, Germany
    Gene 184:141-8. 1997

Research Grants

  1. RADIATION INDUCED RNA BINDING PROTEINS
    France Carrier; Fiscal Year: 2002
  2. Biomodulation of anticancer drugs targeting DNA
    France Carrier; Fiscal Year: 2009

Scientific Experts

  • Julia Kzhyshkowska
  • F Carrier
  • Karen Goossens
  • Magda Grudniewska
  • Mulu Y Lubula
  • Wanil Kim
  • Katrien Smits
  • Lucie Roussel
  • Francesco Nicassio
  • Michael T Boyne
  • W Albig
  • Stijn Mouton
  • Katrien De Mulder
  • Wibowo Arindrarto
  • Stefan van der Elst
  • Philipp M Weissert
  • Margriet Grelling
  • Daniil Simanov
  • Eugene Berezikov
  • Frank Beltman
  • Samuel Carlson
  • Amanda Poplawski
  • Brian E Eckenroth
  • Maksymilian Chruszcz
  • Karen C Glass
  • Joon Shin
  • Nagakumar Bharatham
  • Kyong Tai Kim
  • Min Woo Jeong
  • Choon Ho Park
  • Goutam Chakraborty
  • Ho Sup Yoon
  • Sangjune Kim
  • Emilie Vanhaesebrouck
  • Jan Govaere
  • Maarten Hoogewijs
  • Ann Van Soom
  • Jo Vandesompele
  • Silvia Colleoni
  • Luc Peelman
  • Cesare Galli
  • Monique Erard
  • Jean Philippe Girard
  • Corinne Cayrol
  • Wim Vermeulen
  • Nadia Corrado
  • Adriaan B Houtsmuller
  • Jurgen A Marteijn
  • Steven Bergink
  • Liliana B Areces
  • Pier Paolo Di Fiore
  • Elisabetta Citterio
  • Joseph H A Vissers
  • Bart Geverts
  • James J Pesavento
  • Craig A Mizzen
  • D Doenecke
  • Y Zhang
  • Neil L Kelleher
  • E Kardalinou
  • S Eick
  • R Trappe
  • Z W Sun
  • M Hampsey
  • H Erdjument-Bromage
  • D Reinberg
  • R Iratni
  • P Tempst
  • T Meergans
  • T Ohshige
  • T Nakayama
  • S Takechi
  • T W Du Clos
  • L T Zlock
  • L Marnell

Detail Information

Publications14

  1. pmc Selection of reference genes for quantitative real-time PCR in equine in vivo and fresh and frozen-thawed in vitro blastocysts
    Katrien Smits
    Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium
    BMC Res Notes 2:246. 2009
    ..In this study a set of reliable reference genes was identified for equine in vivo and fresh and frozen-thawed in vitro embryos...
  2. ncbi Precise characterization of human histones in the H2A gene family by top down mass spectrometry
    Michael T Boyne
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Proteome Res 5:248-53. 2006
    ..This unequivocal identification of H2A forms illustrates the advantages of Top Down Mass Spectrometry and provides a global perspective of H2A regulation through the cell cycle...
  3. ncbi Human USP3 is a chromatin modifier required for S phase progression and genome stability
    Francesco Nicassio
    IFOM, Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Curr Biol 17:1972-7. 2007
    ..Together, our results implicate USP3 as a novel chromatin modifier in the maintenance of genome integrity...
  4. pmc Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket
    Lucie Roussel
    CNRS, IPBS Institute of Pharmacology and Structural Biology, 205 route de Narbonne, F 31077 Toulouse, France
    EMBO Rep 9:1006-12. 2008
    ..In addition, the data provide, to the best of our knowledge, the first demonstration of the existence of non-histone cellular factors that bind to the acidic pocket of the nucleosome...
  5. pmc Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase
    Wanil Kim
    Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang 790 784, Republic of Korea
    J Biol Chem 287:5278-89. 2012
    ..2 by NMR spectroscopy. Hence, our findings might provide valuable insight into the underlying molecular mechanism regarding an epigenetic regulation of histone H3 during the cell cycle...
  6. pmc Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain
    Mulu Y Lubula
    Department of Pharmaceutical Science, Albany College of Pharmacy and Health Sciences, Colchester, VT 05446, USA
    FEBS Lett 588:3844-54. 2014
    ..Our results provide critical insights into the molecular mechanism of ligand binding by the BRPF1 bromodomain, and reveal that ordered water molecules are an essential component driving ligand recognition. ..
  7. pmc Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano
    Magda Grudniewska
    European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    elife 5:. 2016
    ..The generated M. lignano transcriptome assembly and gene expression signatures of somatic neoblasts and germline cells will be a valuable resource for future molecular studies in M. lignano...
  8. ncbi Definition of a C-reactive protein binding determinant on histones
    T W Du Clos
    Veterans Administration Medical Center, Albuquerque, New Mexico 87108
    J Biol Chem 266:2167-71. 1991
    ..Thus we have defined the first reported CRP binding determinant on a protein...
  9. ncbi Presence of particular transcription regulatory elements in the 5'-intergenic region shared by the chicken H2A-III and H2B-V pair
    T Ohshige
    Department of Biochemistry, Miyazaki Medical College, Japan
    Gene 131:193-9. 1993
    ..These findings, together with those reported previously on the H2A-V/H2B-II pair, suggest distinct manners of transcription regulation of different members of the chicken histone gene families, H2A and H2B...
  10. ncbi Characterization of the H1.5 gene completes the set of human H1 subtype genes
    W Albig
    Institut fur Biochemie und Molekulare Zellbiologie, Universitaet Goettingen, Germany
    Gene 184:141-8. 1997
    ..The H2B sequence shows no typical regulatory elements and no complete ORF, therefore we consider it as a pseudogene. The expression of the H1.5 gene was examined in several cell lines...
  11. ncbi SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex
    Y Zhang
    Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School Piscataway, New Jersey 08854, USA
    Mol Cell 1:1021-31. 1998
    ..These results define SAP30 as a component of a histone deacetylase complex conserved among eukaryotic organisms...
  12. pmc Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin
    F Carrier
    Laboratory of Biological Chemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Mol Cell Biol 19:1673-85. 1999
    ..Both histone acetylation and UV radiation are thought to destabilize the nucleosomal structure. Hence, these results imply that Gadd45 can recognize an altered chromatin state and modulate DNA accessibility to cellular proteins...
  13. ncbi The human H2A and H2B histone gene complement
    W Albig
    Institut fur Biochemie und Molekulare Zellbiologie, Universitat Gottingen, Germany
    Biol Chem 380:7-18. 1999
    ..The genes show varying expression patterns in different tumor cell lines...
  14. pmc Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7
    Julia Kzhyshkowska
    Universitat Heidelberg, Uni Klinikum Mannheim, Dermatologie, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Biochem J 371:385-93. 2003
    ..We conclude that complex formation between BRD7 and E1B-AP5 links chromatin events with mRNA processing at the level of transcriptional regulation...

Research Grants2

  1. RADIATION INDUCED RNA BINDING PROTEINS
    France Carrier; Fiscal Year: 2002
    ..We also plan to study the role of A-18, an independently isolated clone coding for a RBP induced by ultra-violet light, in the stress response. ..
  2. Biomodulation of anticancer drugs targeting DNA
    France Carrier; Fiscal Year: 2009
    ..This proposal will provide a better understanding of the basic mechanisms mediating this effect and will contribute to guide and develop mechanism-based therapeutics for cancer treatments. ..