HIF-1 alpha

Summary

Gene Symbol: HIF-1 alpha
Description: hypoxia inducible factor 1 alpha subunit
Alias: HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia-inducible factor 1-alpha, ARNT interacting protein, PAS domain-containing protein 8, basic-helix-loop-helix-PAS protein MOP1, class E basic helix-loop-helix protein 78, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1 alpha isoform I.3, hypoxia-inducible factor1alpha, member of PAS protein 1, member of PAS superfamily 1
Species: human

Top Publications

  1. ncbi Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer
    R Bos
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Histopathology 46:31-6. 2005
  2. doi Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores
    Hanna Hartmann
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat, Tubingen, Germany
    Gastroenterology 134:756-67. 2008
  3. pmc Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    J A Forsythe
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Mol Cell Biol 16:4604-13. 1996
  4. ncbi Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    P Jaakkola
    The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Science 292:468-72. 2001
  5. pmc Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 92:5510-4. 1995
  6. ncbi Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    Rebecca J Appelhoff
    Henry Wellcome Bldg of Genomic Medicine, Roosevelt Drive, Headington, Oxford, UK
    J Biol Chem 279:38458-65. 2004
  7. doi Direct regulation of TWIST by HIF-1alpha promotes metastasis
    Muh Hwa Yang
    Institutes of Biochemistry and Molecular Biology, National Yang Ming University, No 155, Sec 2, Li Niong Street, Peitou, Taipei 112, Taiwan
    Nat Cell Biol 10:295-305. 2008
  8. pmc A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 12:5447-54. 1992
  9. pmc HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    John D Gordan
    Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cancer Cell 11:335-47. 2007
  10. ncbi HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    M Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 292:464-8. 2001

Research Grants

  1. Sam Thiagalingam; Fiscal Year: 2014
  2. VEGF Function in B-CLL
    Neil E Kay; Fiscal Year: 2010
  3. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
  4. John H Nilson; Fiscal Year: 2014
  5. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Wesley Dewhirst; Fiscal Year: 2013
  6. OXYGEN SENSING AND OSTEOGENESIS
    Thomas L Clemens; Fiscal Year: 2013
  7. Karen Block; Fiscal Year: 2015
  8. ROBERT MICHAEL ROBERTS; Fiscal Year: 2015
  9. Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2
    Cheng Jun Hu; Fiscal Year: 2012
  10. Chandan K Sen; Fiscal Year: 2016

Detail Information

Publications426 found, 100 shown here

  1. ncbi Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer
    R Bos
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Histopathology 46:31-6. 2005
    ..This study investigated if angiogenesis or growth factors or their receptors are associated with HIF-1alpha in invasive breast cancer...
  2. doi Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores
    Hanna Hartmann
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Tubingen, Eberhard Karls Universitat, Tubingen, Germany
    Gastroenterology 134:756-67. 2008
    ..However, molecular details of how bacteria activate HIF-1 remain unclear. Here, we pursued the role of bacterial siderophores in HIF-1 activation during infection with Enterobacteriaceae...
  3. pmc Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    J A Forsythe
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Mol Cell Biol 16:4604-13. 1996
    ..VEGF mRNA was not induced by hypoxia in mutant cells that do not express the HIF-1beta (ARNT) subunit. These findings implicate HIF-1 in the activation of VEGF transcription in hypoxic cells...
  4. ncbi Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    P Jaakkola
    The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Science 292:468-72. 2001
    ..An absolute requirement for dioxygen as a cosubstrate and iron as cofactor suggests that HIF-PH functions directly as a cellular oxygen sensor...
  5. pmc Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    Proc Natl Acad Sci U S A 92:5510-4. 1995
    ....
  6. ncbi Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    Rebecca J Appelhoff
    Henry Wellcome Bldg of Genomic Medicine, Roosevelt Drive, Headington, Oxford, UK
    J Biol Chem 279:38458-65. 2004
    ....
  7. doi Direct regulation of TWIST by HIF-1alpha promotes metastasis
    Muh Hwa Yang
    Institutes of Biochemistry and Molecular Biology, National Yang Ming University, No 155, Sec 2, Li Niong Street, Peitou, Taipei 112, Taiwan
    Nat Cell Biol 10:295-305. 2008
    ..These results provide evidence of a key signalling pathway involving HIF-1alpha and TWIST that promotes metastasis in response to intratumoural hypoxia...
  8. pmc A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    G L Semenza
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 12:5447-54. 1992
    ..We have thus defined a functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by hypoxia via de novo protein synthesis...
  9. pmc HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    John D Gordan
    Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cancer Cell 11:335-47. 2007
    ..Enhanced c-Myc activity likely contributes to HIF-2alpha-mediated neoplastic progression following loss of the VHL tumor suppressor and influences the behavior of hypoxic tumor cells...
  10. ncbi HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
    M Ivan
    Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Science 292:464-8. 2001
    ..Because proline hydroxylation requires molecular oxygen and Fe(2+), this protein modification may play a key role in mammalian oxygen sensing...
  11. ncbi A conserved family of prolyl-4-hydroxylases that modify HIF
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 294:1337-40. 2001
    ..These findings indicate that HPH is an essential component of the pathway through which cells sense oxygen...
  12. ncbi Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways
    Tilman Sanchez-Elsner
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040 Madrid, Spain
    J Biol Chem 277:43799-808. 2002
    ..We propose that basal endoglin transcription (highly dependent on Sp1) may switch from a constitutive to an inducible state through Sp1 interaction with HIF-1 and Smad transcription factors, induced by hypoxia and TGF-beta, respectively...
  13. doi Wnt/β-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling
    Qi Zhang
    Department of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
    Carcinogenesis 34:962-73. 2013
    ..Our results suggest that Wnt/β-catenin signaling enhances hypoxia-induced EMT in HCC by increasing the EMT-associated activity of hif-1α and preventing tumor cell death...
  14. ncbi Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
    Jung Hyun Min
    Cellular Biochemistry and Biophysics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 296:1886-9. 2002
    ..Although the beta sheet-like interactions contribute to the stability of the complex, the hydroxyproline contacts are central to the strict specificity characteristic of signaling...
  15. pmc HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
    Minori Koshiji
    Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 23:1949-56. 2004
    ..Hence, we propose that Myc is an integral part of a novel HIF-1alpha pathway, which regulates a distinct group of Myc target genes in response to hypoxia...
  16. ncbi HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    Ryo Fukuda
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 129:111-22. 2007
    ..Thus, mammalian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, but by a completely different molecular mechanism...
  17. pmc Regulation of hypoxia-inducible factor-1alpha by NF-kappaB
    Patrick van Uden
    College of Life Sciences, Wellcome Trust Centre for Gene Regulation and Expression, MSI WTB JBC Complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 412:477-84. 2008
    ..In conclusion, we find that NF-kappaB can regulate basal TNFalpha and, in certain circumstances, the hypoxia-induced HIF-1alpha...
  18. ncbi p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    D E Richard
    Institute of Signaling, Developmental Biology and Cancer Research, UMR CNRS 6543, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    J Biol Chem 274:32631-7. 1999
    ..This interaction between HIF-1alpha and p42/p44 MAPK suggests a cooperation between hypoxic and growth factor signals that ultimately leads to the increase in HIF-1-mediated gene expression...
  19. ncbi Signal transduction to hypoxia-inducible factor 1
    Gregg Semenza
    Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 1004, Baltimore, MD 21287 3914, USA
    Biochem Pharmacol 64:993-8. 2002
    ....
  20. pmc Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression
    Satish L Deshmane
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Biol Chem 284:11364-73. 2009
    ....
  21. pmc Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
    Jung whan Kim
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 27:7381-93. 2007
    ....
  22. ncbi IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
    Yun Jin Jung
    Cell and Cancer Biology Branch, CCR, National Cancer Institute, 9610 Medical Center Dr, Suite 300, Rockville, Maryland 20850, USA
    FASEB J 17:2115-7. 2003
    ..Thus, HIF-1 is identified as a pivotal transcription factor linking the inflammatory and oncogenic pathways...
  23. ncbi Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha
    Yong Yuan
    Genome Research Institute, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0505, USA
    J Biol Chem 278:15911-6. 2003
    ..These findings show that cobalt mimics hypoxia, at least in part, by occupying the VHL-binding domain of HIF-alpha and thereby preventing the degradation of HIF-alpha...
  24. ncbi Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
    W G An
    Department of Cell and Cancer Biology, Medicine Branch, NCI, NIH, Bethesda, Maryland 20892, USA
    Nature 392:405-8. 1998
    ..Our results suggest that hypoxic induction of transcriptionally active wild-type p53 is achieved as a result of the stabilization of p53 by its association with HIF-1alpha...
  25. pmc VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha
    Zaibo Li
    Department of Urology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
    EMBO Rep 6:373-8. 2005
    ....
  26. pmc HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs
    Carolyn Culver
    College of Life Sciences, Wellcome Trust Centre for Gene Regulation and Expression, MSI WTB JBC Complex, University of Dundee, Dundee, Scotland, UK
    Cell Cycle 10:1249-60. 2011
    ..These data have important implications in not only for the further understanding of HIF-1α, a major transcription factor, but also for the use of HIF-targeted and combination therapies in cancer treatment...
  27. doi SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
    Marco Montagner
    Department of Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35131 Padua, Italy
    Nature 487:380-4. 2012
    ..This work sheds light on the mechanisms and pathways by which TNBC acquires invasiveness and metastatic propensity...
  28. ncbi Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function
    Sergiu Bogdan Catrina
    Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Diabetes 53:3226-32. 2004
    ..In conclusion, our data demonstrate that hyperglycemia impairs hypoxia-dependent protection of HIF-1alpha against proteasomal degradation and suggest a mechanism by which diabetes interferes with cellular responses to hypoxia...
  29. pmc BRCA1 tumours correlate with a HIF-1alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression
    M Yan
    Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Br J Cancer 101:1168-74. 2009
    ..There are limited data regarding the hypoxia pathway in familial breast cancers. We therefore performed a study of hypoxic factors in BRCA1, BRCA2 and BRCAX breast cancers...
  30. pmc Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration
    Zhang Lei
    Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People s Republic of China
    PLoS ONE 4:e7629. 2009
    ..Thus, we identify a novel molecular regulation mechanism through which miR-20b regulates HIF-1alpha and VEGF and is regulated by HIF-1alpha so to keep tumor cells adapting to different oxygen concentrations...
  31. doi The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors
    Hiroshi Harada
    Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Biol Chem 284:5332-42. 2009
    ....
  32. pmc HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    F Yu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Cancer Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Proc Natl Acad Sci U S A 98:9630-5. 2001
    ..The data furthermore show that this proline hydroxylation is the primary regulator of VHL binding...
  33. pmc Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
    Shweta Rane
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Division of Nephrology, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Circ Res 104:879-86. 2009
    ..In addition, the data demonstrate a functional link between 2 key molecules that regulate hypoxia preconditioning and longevity...
  34. ncbi High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer
    Petra van der Groep
    Department of Pathology, University Medical Center, 3508 GA, Utrecht, The Netherlands
    Breast Cancer Res Treat 111:475-80. 2008
    ..69%, P = 0.0002). Glut-1 and CAIX, downstream HIF1 targets, were expressed in 27/30 (90%) and 15/21 (71%) of hereditary cases versus 54/183 (29%) and 24/183 (13%) in ..
  35. pmc Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300
    M Ema
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 77, Japan
    EMBO J 18:1905-14. 1999
    ..Nuclear translocation of thioredoxin from cytoplasm was observed upon reducing O2 concentrations...
  36. ncbi Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL
    Wai Ching Hon
    Division of Structural Biology, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 417:975-8. 2002
    ..This mechanism provides a new focus for development of therapeutic agents to modulate cellular responses to hypoxia...
  37. pmc Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    Christine C Hudson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 22:7004-14. 2002
    ..These studies position mTOR as an upstream activator of HIF-1 function in cancer cells and suggest that the antitumor activity of rapamycin is mediated, in part, through the inhibition of cellular responses to hypoxic stress...
  38. ncbi CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2
    Jean Pascal Piret
    Laboratoire de Biologie et Biochimie Cellulaire, FUNDP, 5000 Namur, Belgium
    Ann N Y Acad Sci 973:443-7. 2002
    ..These different data suggest a possible antiapoptotic role of HIF-1. More experiments are needed to define if HIF-1 actually plays an active role in cell death protection and to determine the exact mechanism underlying this effect...
  39. pmc BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}
    Ni Chen
    Laboratory of Pathology, Departments of Pathology and Urology, and Laboratory of Stem Cell Research, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China 610041
    J Biol Chem 284:10004-12. 2009
    ..HIF-1alpha-dependent BCL-xL overexpression may be an important mechanism by which HIF-1alpha protects prostate cancer cells from apoptosis and leads to treatment resistance...
  40. pmc A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxia
    Qiliang Cai
    Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    J Virol 81:10413-23. 2007
    ..Therefore, these data show that LANA can function not only as an inhibitor of HIF-1alpha suppressor proteins but can also induce nuclear accumulation of HIF-1alpha during KSHV latent infection...
  41. pmc Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
    Xiaobo Xia
    Department of Pediatric Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:4260-5. 2009
    ..These results suggest that the coordinated increase in expression of several oxygen-dependent enzymes by HIF may help compensate for decreased levels of oxygen under conditions of cellular hypoxia...
  42. pmc VEGF, HIF-1α expression and MVD as an angiogenic network in familial breast cancer
    Concetta Saponaro
    Functional Biomorphology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Bari, Italy
    PLoS ONE 8:e53070. 2013
    ..Prospective studies in larger BRCA1-2 carrier series are needed to improve the best therapeutic strategies for this subgroup of breast cancer patients...
  43. doi STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy
    João Vasco Ferreira
    Center of Ophthalmology and Vision Sciences Institute for Biomedical Imaging and Life Science IBILI Faculty of Medicine University of Coimbra Coimbra, Portugal
    Autophagy 9:1349-66. 2013
    The transcription factor HIF1 is mostly regulated by the oxygen-dependent proteasomal degradation of the labile subunit HIF1A. Recent data showed degradation of HIF1A in the lysosome through chaperone-mediated autophagy (CMA)...
  44. pmc HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
    Edurne Berra
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    EMBO J 22:4082-90. 2003
    ..Interestingly, PHD2 is upregulated by hypoxia, providing an HIF-1-dependent auto-regulatory mechanism driven by the oxygen tension...
  45. ncbi Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells
    Seok J Kwon
    Department of Surgery, School of Medicine, University of Pittsburgh, PA 15213, USA
    Clin Cancer Res 11:7607-13. 2005
    ..Human pancreatic cancer MiaPaCa-2 cells were exposed to low glucose (0.1 mmol/L) with hypoxia (0.1% O(2))...
  46. pmc Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization
    Xiaowei Zheng
    Department of Cell and Molecular Biology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Mol Cell Biol 26:4628-41. 2006
    ....
  47. ncbi HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome
    Cynthia Trastour
    Institute of Signalling, Developmental Biology and Cancer Research, University of Nice, Nice, France
    Int J Cancer 120:1451-8. 2007
    ..CA IX is, however, a weaker prognostic and predictive factor than HIF-1alpha, and its association with HIF-1alpha does not modify the survival curve neither response to therapy, compared to HIF-1alpha alone...
  48. doi Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)
    Zhi Bo Han
    The State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, China
    Carcinogenesis 29:1853-61. 2008
    ..Hypoxia and epidermal growth factor receptor signal coexisted in the tumor microenvironment and might promote angiogenesis through HIF-1 alpha-mediated upregulation of SCF and other angiogenic factors...
  49. pmc Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect
    Suhas Darekar
    Department of Microbiology, Tumor and Cell Biology MTC, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 7:e42072. 2012
    ..The role of HIF1A in EBV-induced B-cell immortalization has not been previously studied...
  50. pmc HIF1-alpha expression predicts survival of patients with squamous cell carcinoma of the oral cavity
    Marcelo dos Santos
    Programa de Pós Graduação, Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 7:e45228. 2012
    ..b>HIF1α protein is associated with hypoxia response and neovascularization, essential conditions for solid tumors ..
  51. pmc Hypoxia inducible factor 1alpha gene (HIF-1alpha) splice variants: potential prognostic biomarkers in breast cancer
    Jean Philippe Dales
    Plateforme Transcriptome, CRO2, Marseille, France
    BMC Med 8:44. 2010
    ..The prognostic relevance of HIF-1alpha protein overexpression has been shown in breast cancer. The impact of HIF-1alpha alternative splice variant expression on breast cancer prognosis in terms of metastasis risk is not well known...
  52. pmc Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophils
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Chatham Maritime, United Kingdom
    PLoS ONE 7:e34259. 2012
    ..This transcription complex facilitates generation of both pro-angiogenic and inflammatory cytokines in mast cells but has a differential role in basophil stimulation comparing IgE-dependent triggering with innate immune stimuli...
  53. ncbi Hypoxia-inducible factor-1 transactivates transforming growth factor-beta3 in trophoblast
    Hirotaka Nishi
    Department of Obstetrics and Gynecology, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku, Tokyo 160 0023, Japan
    Endocrinology 145:4113-8. 2004
    ..Our results provide evidence that regulation of TGF-beta3 promoter activity by HIF-1 represents a mechanism for trophoblast differentiation during hypoxia...
  54. ncbi Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function
    Jonathan Jantsch
    Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 180:4697-705. 2008
    ..Alltogether, our data indicate that HIF-1alpha and hypoxia play a crucial role for DC activation in inflammatory states, which is highly dependent on glycolysis even in the presence of oxygen...
  55. ncbi Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1
    Ryo Fukuda
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Cancer Res 63:2330-4. 2003
    ..Thus, the activity of multiple signal transduction pathways is required for the HIF-1-mediated induction of VEGF expression in colon cancer cells exposed to PGE(2)...
  56. doi Hypoxia inducible factor-1α in human emphysema lung tissue
    M Yasuo
    Pulmonary and Critical Care Medicine Division and Victoria Johnson Center for Obstructive Lung Diseases, Virginia Commonwealth University, Richmond, VA, USA
    Eur Respir J 37:775-83. 2011
    ..In conclusion, reduced expression of HIF-1α protein in severe COPD is consistent with the concept of a lung structure maintenance programme which is impaired on a molecular level...
  57. ncbi Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer
    Seok Jin Kim
    Department of Medicine, Duke University Medical Center and Durham Veterans Affairs Hospital, Durham, NC 27705, USA
    Lung Cancer 49:325-35. 2005
    ..Of the markers considered in this study, CA IX expression status was the most reliable hypoxia marker for predicting tumor aggressiveness...
  58. ncbi Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
    B H Jiang
    Center for Medical Genetics, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Biol Chem 272:19253-60. 1997
    ..These results indicate that increased transcriptional activity mediated by HIF-1 in hypoxic cells results from both increased HIF-1alpha protein levels and increased activity of HIF-1alpha transactivation domains...
  59. ncbi Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
    Y Makino
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Nature 414:550-4. 2001
    ..These results indicate a previously unknown mechanism for negative regulation of angiogenesis and maintenance of an avascular phenotype...
  60. pmc Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha
    Naohiro Wakisaka
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Mol Cell Biol 24:5223-34. 2004
    ..The ability of EBV, and specifically its major oncoprotein, LMP1, to induce HIF-1 alpha along with other invasiveness and angiogenic factors reported previously discloses additional oncogenic properties of this tumor virus...
  61. pmc Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses
    Mitsuhiro Nakamura
    Department of Microbiology Immunology, Northwestern University, Feinberg School of Medicine, Morton, Chicago, IL 60611, USA
    Virology 387:442-8. 2009
    ..These findings shed light on mechanisms by which HPV contributes to angiogenesis both in benign cervical lesions and in cervical cancers...
  62. pmc MCM proteins are negative regulators of hypoxia-inducible factor 1
    Maimon E Hubbi
    Graduate Training Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 42:700-12. 2011
    ..Exposure to hypoxia leads to MCM2-7 downregulation in diverse cell types. These studies reveal a function of MCM proteins apart from their DNA helicase activity and establish a direct link between HIF-1 and the cell-cycle machinery...
  63. pmc Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
    Nat Med 18:774-82. 2012
    ....
  64. pmc BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha
    Jee Youn Kim
    Department of Pathology, College of Medicine, Kyung Hee University, 1 Hoegi dong, Dongdaemoon Koo, Seoul 130 701, Korea
    J Exp Med 199:113-24. 2004
    ..Further, we show that reactive oxygen species and resultant cytochrome c release participate in Noxa-mediated hypoxic cell death. Altogether, our results show that Noxa is induced by HIF-1alpha and mediates hypoxic cell death...
  65. pmc Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    Raju R Raval
    The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, United Kingdom
    Mol Cell Biol 25:5675-86. 2005
    ..These findings indicate that therapeutic approaches to targeting of the HIF system, at least in this setting, will need to take account of HIF isoform-specific functions...
  66. ncbi Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity
    Hiroyuki Kato
    Department of Molecular Cell Physiology, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    J Biol Chem 279:41966-74. 2004
    ..Taken together, these results indicate that HDAC7 is a novel transcriptional activator of HIF-1alpha..
  67. ncbi Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
    Linda Holmquist-Mengelbier
    Division of Molecular Medicine, Department of Laboratory Medicine, Lund University, University Hospital MAS, SE 205 02 Malmo, Sweden
    Cancer Cell 10:413-23. 2006
    ..Our results demonstrate the relevance of HIF-2alpha in neuroblastoma progression and have general tumor biological implications...
  68. ncbi Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    Abderrahmane Kaidi
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK
    Nat Cell Biol 9:210-7. 2007
    ..This study highlights the importance of the microenvironment in transcriptional regulation...
  69. pmc PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis
    Amandine Ginouves
    Institute of Signaling, Developmental Biology, and Cancer Research, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6543, University of Nice, Centre Antoine Lacassagne, 06189 Nice, France
    Proc Natl Acad Sci U S A 105:4745-50. 2008
    ..However, here we show that chronic hypoxia induces HIF1/2alpha"desensitization" in cellulo and in mice...
  70. ncbi Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression
    T Sanchez-Elsner
    Centro de Investigaciones Biologicas, CSIC, Velazquez 144, 28006 Madrid, Spain
    J Biol Chem 276:38527-35. 2001
    ..These results demonstrate that both TGF-beta and hypoxia signaling pathways can synergize in the regulation of VEGF gene expression at the transcriptional level...
  71. pmc FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    P C Mahon
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    Genes Dev 15:2675-86. 2001
    ..Involvement of VHL in association with FIH-1 provides a unifying mechanism for the modulation of HIF-1alpha protein stabilization and transcriptional activation in response to changes in cellular O(2) concentration...
  72. ncbi Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
    Kirsty S Hewitson
    Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom
    J Biol Chem 282:3293-301. 2007
    ....
  73. doi Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells
    Seung Nam Jung
    Department of Biochemistry and Molecular Biology, Kyung Hee University School of Medicine, Seoul 130 701, Korea
    Carcinogenesis 29:713-21. 2008
    ..Collectively, our findings identify AMPK as a key determinant of HIF-1 functions in response to ROS and its possible role in the sophisticated HIF-1 regulatory mechanisms...
  74. pmc Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
    Shimin Zhao
    Molecular and Cell Biology Laboratory, Institute of Biomedical Sciences, Fudan University, 130 Dong an Road, Shanghai 200032, China
    Science 324:261-5. 2009
    ..Thus, IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway...
  75. pmc MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia
    Ulrike Bruning
    School of Medicine and Medical Science and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Mol Cell Biol 31:4087-96. 2011
    ....
  76. pmc General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    G L Wang
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 90:4304-8. 1993
    ..These results provide evidence that HIF-1 and its recognition sequence are common components of a general mammalian cellular response to hypoxia...
  77. ncbi In vivo expression of mRNAs encoding hypoxia-inducible factor 1
    C M Wiener
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biochem Biophys Res Commun 225:485-8. 1996
    ..The ubiquitous in vivo expression of HIF-1 alpha and HIF-1 beta (ARNT) mRNA is consistent with the proposed role of HIF-1 in coordinating adaptive transcriptional responses to hypoxia...
  78. ncbi Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    David Lando
    Department of Molecular Biosciences Biochemistry, Adelaide University, SA 5005, Australia
    Science 295:858-61. 2002
    ..Full induction of HIF-1alpha and -2alpha, therefore, relies on the abrogation of both Pro and Asn hydroxylation, which during normoxia occur at the degradation and COOH-terminal transactivation domains, respectively...
  79. pmc MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
    Nianli Sang
    Cardeza Foundation for Hematological Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 278:14013-9. 2003
    ..Taken together, our data suggest that MAPK signaling facilitates HIF activation through p300/CBP...
  80. ncbi Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
    P J Pollard
    Molecular and Population Genetics Laboratory, London WC2A 3PX, UK
    Hum Mol Genet 14:2231-9. 2005
    ..The basic mechanism of tumorigenesis in HPGL and HLRCC is likely to be pseudo-hypoxic drive, just as it is in von Hippel-Lindau syndrome...
  81. pmc High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF
    Andreas Claudius Hoffmann
    Department of Biochemistry and Molecular Biology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
    Neoplasia 10:674-9. 2008
    ..In this study, we investigated the prognostic values of HIF1a, bFGF, VEGF, and PDGFA gene expressions as well as their interrelationships...
  82. ncbi Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase
    Stefan Kaluz
    Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Cancer Res 62:4469-77. 2002
    ..These interdependent pathways function at a lowered O(2) concentration that is, however, above that necessary for HIF-1 alpha stabilization...
  83. ncbi Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
    Delin Chen
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Biol Chem 278:13595-8. 2003
    ..These results have significant implications regarding the molecular mechanism by which p53 is activated by HIF-1 alpha in response to hypoxia...
  84. pmc Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha
    Donna M Fath
    Cardeza Foundation for Hematologic Research and Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 281:13612-9. 2006
    ....
  85. pmc Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts
    David R Mole
    Henry Wellcome Building of Molecular Physiology, University of Oxford, Oxford OX3 7BN, United Kingdom
    J Biol Chem 284:16767-75. 2009
    ..Given emerging evidence for biologically distinct functions of HIF-1alpha versus HIF-2alpha understanding the mechanisms restricting HIF-2alpha activity will be of interest...
  86. pmc Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha
    P Carrero
    Department of Cell and Molecular Biology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Mol Cell Biol 20:402-15. 2000
    ....
  87. doi Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction
    P Storti
    Hematology, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
    Leukemia 27:1697-706. 2013
    ..Overall, our data indicate that HIF-1α suppression in MM cells significantly blocks MM-induced angiogenesis and reduces MM tumor burden and bone destruction in vivo, supporting HIF-1α as a potential therapeutic target in MM. ..
  88. doi HIF-1A gene mutations associated with higher microvessel density in endometrial carcinomas
    N Horree
    Histopathology 52:637-9. 2008
  89. pmc Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells
    Zhenyu Ding
    Department of Oncology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China
    J Cancer Res Clin Oncol 136:1697-707. 2010
    ....
  90. pmc The role of Aurora A in hypoxia-inducible factor 1α-promoting malignant phenotypes of hepatocelluar carcinoma
    Shi Yun Cui
    Department of Medical Oncology Jinling Hospital School of Medicine Nanjing University Nanjing, PR China
    Cell Cycle 12:2849-66. 2013
    ..Taken together, our findings indicated that Aurora A might be a key regulator of HIF-1α-promoting malignant phenotypes of HCC by activation of Akt and p38-MAPK signaling pathways...
  91. ncbi Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta
    A Rajakumar
    Departments of Obstetrics, Gynecology and Reproductive Sciences and of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Reprod 63:559-69. 2000
    ....
  92. ncbi Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7
    S Cho
    Center for Cellular Switch Protein Structure, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, South Korea
    FEBS Lett 498:62-6. 2001
    ..PSMA7 inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions. In addition, we show that the PSMA7-mediated regulation of HIF-1alpha activity is associated with the proteasome pathway...
  93. ncbi SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation
    M Tan
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 096, USA
    Oncogene 27:1404-11. 2008
    ..Induced SAG then promotes HIF-1alpha ubiquitination and degradation. This feedback loop may serve as a cellular defensive mechanism to reduce potential cytotoxic effects of prolonged HIF-1 activation under hypoxia...
  94. pmc Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism
    Kristina M Cook
    NCI, National Institutes of Health, Bethesda, Maryland 20814, USA
    J Biol Chem 284:26831-8. 2009
    ..The results have implications for the design of selective ETPs and for the interaction of ETPs with other zinc ion-binding protein targets involved in gene expression...
  95. doi HIF1-regulated ATRIP expression is required for hypoxia induced ATR activation
    Gang Ding
    Department of Oncology, Chongming Branch of Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    FEBS Lett 587:930-5. 2013
    ..Taken together, these data shed novel insights on the mechanism of hypoxia-induced activation of the ATR pathway...
  96. pmc Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    Cheng Jun Hu
    Abramson Family Cancer Research Institute Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Mol Cell Biol 23:9361-74. 2003
    ..Importantly, HIF-1alpha (and not HIF-2alpha) stimulates glycolytic gene expression in both types of cells, clearly showing for the first time that HIF-1alpha and HIF-2alpha have unique targets...
  97. ncbi The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer
    Stuart C Winter
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Cancer 107:757-66. 2006
    ..Anemia may contribute to hypoxia by reducing oxygen delivery, but it is not known whether this influences HIF-alpha expression in tumors...
  98. doi The expression of HIF-1α in primary hepatocellular carcinoma and its correlation with radiotherapy response and clinical outcome
    Zuo Lin Xiang
    Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 136 Yi Xue Yuan Road, Shanghai 200032, China
    Mol Biol Rep 39:2021-9. 2012
    ..020) were independent prognosis factors for OS of HCC patients after receiving abdominal metastatic LN EBRT. HIF-1α expression in primary HCCs was associated with EBRT response of abdominal metastatic LNs and poor prognosis...
  99. doi Hypoxia-inducible factor-1α and excision repair cross-complementing 1 in patients with small cell lung cancer who received front-line platinum-based chemotherapy: a retrospective study
    Gyeong Won Lee
    Division of Hematology Oncology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
    J Thorac Oncol 7:528-34. 2012
    ....
  100. doi Clinicopathological significance of hypoxia-inducible factor-1 alpha (HIF-1α) expression in gastric cancer
    Taro Isobe
    Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, 830 0011, Japan
    Int J Clin Oncol 18:293-304. 2013
    ..In this study, we evaluated the significance of HIF-1α expression in relationship to clinicopathological factors, prognosis, vascular endothelial growth factor (VEGF) expression, and microvessel density (MVD)...
  101. doi Glucose plays a main role in human fibroblasts adaptation to hypoxia
    Alessandra Baracca
    Dipartimento di Scienze Biomediche e Neuromotorie, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Int J Biochem Cell Biol 45:1356-65. 2013
    ..Therefore, our data show for the first time that glucose availability significantly affects the hypoxia-induced HIF-1/BNIP3 response, and in particular glucose absence results in enhancing the OXPHOS rate...

Research Grants67

  1. Sam Thiagalingam; Fiscal Year: 2014
    ..inhibited VEGF reporter activity and Smad4 physically interacts with specific transcription factors (TFs) such as HIF1? to potentially regulat metastatic progression of colon cancer...
  2. VEGF Function in B-CLL
    Neil E Kay; Fiscal Year: 2010
    ..3) Does the VEGF/VEGF-R pathway(s) found in CLL B cells correlate with either clinical and/or critical biologic parameters in B-CLL? ..
  3. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
    ..growth factor (VEGF), and this response is transcriptionally directed by the hypoxia inducible factor 1? (HIF1?). ECs secrete VEGF and VEGF in turn activates VEGFR2 receptors on ECs in an autocrine and paracrine manner...
  4. John H Nilson; Fiscal Year: 2014
    ..HIF1a, together with constitutively expressed HIF1b, form the heterodimeric transcriptional factor HIF1 that activates a hierarchy of target genes that permit cells to survive under reduced oxygen concentrations...
  5. HEAT AND RADIATION EFFECTS ON TUMOR MICROCIRCULATION
    Mark Wesley Dewhirst; Fiscal Year: 2013
    ..We refer to this as the HRHV axis. Unregulated tumor angiogenesis is known to be tied to hypoxia, HIF1 and VEGF by our work and that of many others, however, it is unclear how the angiogenic stimulus is maintained over ..
  6. OXYGEN SENSING AND OSTEOGENESIS
    Thomas L Clemens; Fiscal Year: 2013
    ..Using a genetic approach, we have demonstrated that overexpression of HIF1 in mouse osteoblasts through disruption of Vhl profoundly increases angiogenesis and osteogenesis;these processes ..
  7. Karen Block; Fiscal Year: 2015
    ..This work may have major therapeutic implications. ..
  8. ROBERT MICHAEL ROBERTS; Fiscal Year: 2015
    ..Aim 3 will examine a possible model for PE in which up-regulation of stable HIF1 alpha (HIF1A) protein is hypothesized to counteract the effects of high O2 during in vitro development of BMP-hESC and ..
  9. Regulation of Transcriptional Activity of Hypoxia Inducible Factor 2
    Cheng Jun Hu; Fiscal Year: 2012
    ..b>HIF1( and HIF2( are the two major transcription factors responding to low oxygen (hypoxia) in solid tumors...
  10. Chandan K Sen; Fiscal Year: 2016
    ..b>HIF1[unreadable] is abundant in basal keratinocytes at the wound edge and causes growth arrest...
  11. Raul Mostoslavsky; Fiscal Year: 2014
    ....
  12. Regulation of Renal Oxygenation and Blood Pressure
    Pin Lan Li; Fiscal Year: 2006
    ..abstract_text> ..
  13. Ming Chang Hu; Fiscal Year: 2015
    ..b>HIF1/2 activation protects the kidney from IRI...
  14. Gail V W Johnson; Fiscal Year: 2015
    ..HIF, which is composed of the oxygen sensitive HIF1 subunit and the constitutively expressed HIF12, is the transcription factor that is primarily responsible for the ..
  15. Air/liquid interface cultures for alveolar type II cell differentiation
    ROBERT JAMES MASON; Fiscal Year: 2012
    ..This study should also indicate that sustained pulmonary edema will impair type I cell function and provide another reason for the use of supplemental oxygen in acute lung injury. ..
  16. Ernestina Schipani; Fiscal Year: 2016
    ..abstract_text> ..
  17. William G Kaelin; Fiscal Year: 2015
    ..The interaction of pVHL with HIF1 requires that HIF? be prolyl hydroxylated by members of the EglN family, which belong to a recently recognized ..
  18. Ovarian Cancer Initiating Cells: Metabolic Characterization
    Susan Kay Murphy; Fiscal Year: 2012
    ..078). HIF1[unreadable] functions as part of a key transcription factor complex regulating metabolic pathways and processes in ..
  19. Ian J Davis; Fiscal Year: 2016
    ..in oxygen content in tissues, leads to the stabilization of the transcription factors Hypoxia-inducible factor 1 (HIF1) and Hypoxia-inducible factor 2 (HIF2) which normally result in the transcriptional activation of a genetic program ..
  20. Transcriptional and physiological analysis of cardiac HIF1
    Ralph Shohet; Fiscal Year: 2009
    ..It is a transcription factor that is regulated by the effect of ambient oxygen concentration on its stability. HIF1 regulates a panoply of genes involved in response to hypoxia, including factors that augment angiogenesis and favor ..
  21. VEGF Regulation of Hepatic Erythropoietin Synthesis
    Calvin Kuo; Fiscal Year: 2009
    ....
  22. Plk3 in lung cancer
    Dazhong Xu; Fiscal Year: 2012
    ..The result of this study should provide significant new insights into the biology of lung cancer, the mechanism of how environmental relevant nickel metal affects lung cancer, and the potential of Plk3 as therapeutic target. ..
  23. Vinay K Puduvalli; Fiscal Year: 2015
    ..preclinical studies by inhibiting the escape routes including non-VEGF molecular pathways such as overexpression of HIF1[unreadable], PDGF and IGF as well as recruitment of circulating endothelial cells...
  24. Zeljko J Bosnjak; Fiscal Year: 2016
    ..Our findings are likely to have a significant impact in the clinical use of volatile anesthetics. ..
  25. KAREN ELIZABETH POLLOK; Fiscal Year: 2014
    ..The treatment strategies investigated here will use clinically relevant in vivo models and novel multi-targeting approaches and have the potential to improve treatment efficacy and quality of life for patients with GBM. ..
  26. Andrzej S Tarnawski; Fiscal Year: 2016
    ..include analysis of: expression of proteins involved in angiogenesis - VEGF, VEGFR2, P-VEGFR2 as well as HSP90, HIF1, HIF1, importin , AMPK, P-CREB and P-STAT3;their interactions and binding of HIF1, P-CREB and P- STAT3 to the VEGF ..
  27. TGFbeta IN THE BONE MICROENVIRONMENT: ROLE IN TUMOR METASTASIS
    Theresa A Guise; Fiscal Year: 2012
    ..Aim 3 will test whether hypoxia via hypoxia-indicible factor-1( (Hif1() increases TGF( signaling in tumor cells both at the molecular level in vitro and in bone metastases in vivo...
  28. Inhibition of VEGF Signaling Pathway and Metastasis
    Yi Lu; Fiscal Year: 2010
    ....
  29. Vascular targeted pan PI-3 kinase inhibitor prodrug, SF1126 for glioma therapy
    DONALD DURDEN; Fiscal Year: 2012
    ..This proposal will provide useful information for the application of SF1126 to the treatment of malignant glial tumors in man and therefore may potentially improve survival of patients with this form of cancer. ..
  30. Anand K Iyer; Fiscal Year: 2016
    ..data showing potent anti- angiogenic potential for MonoD, and inhibition of the key angiogenic mediators Akt and HIF1[unreadable]...
  31. The Role of HIF-1 in Neurogenic and Behavior Responses to Antidepressants.
    W TIMOTHY O'BRIEN; Fiscal Year: 2013
    ..A new connection between hypoxia signaling and the actions antidepressants could lead to a better understanding of and new approaches to the treatment of affective disorders. ..
  32. HIF-1 Regulation of macrophages in Injured Spinal Cord
    DUSTIN JAMES DONNELLY; Fiscal Year: 2010
    ..Studies in this proposal will examine how the lesion microenvironment drives macrophage inflammatory function. HIF1 is a ubiquitous transcription factor regulating the cellular response to hypoxia...
  33. Yatrik M Shah; Fiscal Year: 2016
    ..Ultimately these studies will determine if HIF2a is a potential therapeutic target in colon inflammation and may provide an alternative strategy for preventing and treating colon cancer. ..
  34. Caleb James Kelly; Fiscal Year: 2015
    ..Finally, a plan is in place to develop the research and academic skills of the applicant to provide training in all aspects necessary for a productive career as a physician scientist. ..
  35. John C He; Fiscal Year: 2016
    ..In addition to FOXO4, the acetylation of NFkB, STAT3, p53, HIF1[unreadable], and Smad3 also modulates their target gene expression and these transcription factors (TFs) are known ..
  36. Abhishek Satishchandran; Fiscal Year: 2016
    ..Bioinformatic miRNA target prediction tools suggest Hypoxia-Inducible Factor 1-[unreadable] (HIF1[unreadable]) is a primary target of miR-122. HIF1[unreadable] is critical to the progression of ALD...
  37. Yatrik M Shah; Fiscal Year: 2016
    ..Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors consisting of an alpha-subunit (HIF1-alpha or HIF2-alpha) and beta-subunit (aryl hydrocarbon nuclear translocator (ARNT)...
  38. Phillip B Messersmith; Fiscal Year: 2015
    ....
  39. Ira J Blader; Fiscal Year: 2016
    ..These studies are likely to provide important information regarding the interaction between Toxoplasma and its host cell. ..
  40. The Regulatory Role of PTEN on CXCR4-mediated Metastasis in Prostate Cancer Cells
    MAHANDRANAUTH ANAND CHETRAM; Fiscal Year: 2011
    ..Furthermore we will determine whether ROS up-regulation of CXCR4 is through the PI3K/AKT/HIF1[unreadable] pathway by western blot analysis and luciferase assay;(iii) determine whether ROS promotes CXCR4-..
  41. ADSS1 inactivation as a promoter of tumor metabolism and lung carcinogenesis
    Christopher R Herzog; Fiscal Year: 2010
    ..The functional relationship between ADSS1, LKB1, AMPK and HIF1 will be the focus of this investigation...
  42. Dietary Supplement Selenium and HIF-1alpha Regulation in Cancer
    Sreenivasulu Chintala; Fiscal Year: 2010
    ..Successful completion of the studies proposed will establish the role of Se in inhibiting HIF-11 in cancer and other disease for a disease free maintenance of life across the life span of an individual. ..
  43. Melanocyte Survival and Transformation: Hypoxia & P13 Kinase/Akt/mTOR Signaling
    Marianne Broome Powell; Fiscal Year: 2010
    ....
  44. TIFFANY NICOLE SEAGROVES; Fiscal Year: 2014
    ....
  45. Imaging and Modifying Hypoxia in Head and Neck Squamous Cell Tumors
    Sydney M Evans; Fiscal Year: 2013
    ..Tissue collected at surgery will be used to assay hypoxia-related biological endpoints including HIF1?, proliferation (Ki67), blood vessels (CD31), apoptosis and pAkt (radiation resistance) and osteopontin (OPN) in ..
  46. David Gius; Fiscal Year: 2016
    ..We hypothesize that agents thought to scavenge or decrease cellular ROS (O2-.) and/or inhibit HIF-1[unreadable] activity will prevent tumors in Sirt3 knockout mice. ..
  47. Microelectrode oxygenation control of tumor necrosis
    Neil Forbes; Fiscal Year: 2006
    ..cell death, and determine the extent that poor oxygenation causes tumor necrosis; and 3) demonstrate that a HIF1-alpha response is critical for cell survival in hypoxic tumor tissue...
  48. Oxygen Therapy in Neonatal Hypoxia-Ischemia
    John Zhang; Fiscal Year: 2007
    ..Our specific hypothesis is that the level and expression of inflammatory cytokines and iNOS increased in injured brain tissues and lead to cell death. ..
  49. Punam Malik; Fiscal Year: 2016
    ..These studies will likely provide new diagnostic bio-markers for assessment of PHT, and novel therapeutic targets for a disease that currently has few or no therapeutic options. ..
  50. Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke
    SHANNON MARIE BAILEY; Fiscal Year: 2013
    ....
  51. Hyeong Reh Choi Kim; Fiscal Year: 2014
    ..mutant into oral keratinocytes, mimicking smoking-associated cancer, results in upregulation of hypoxia signaling (HIF1) pathway, which in turn could increase glucose metabolism, whereas introduction of HPV16-E6 into those cells leads ..
  52. Hajime Sasaki; Fiscal Year: 2014
    ..The healing response present in dKO mice is strongly associated with up-regulation of HIF-1a (hypoxia inducible factor 1 alpha) expression in the lesion and sequential activation of proinflammatory M1 and anti-inflammatory M2 ..
  53. Ningjun Li; Fiscal Year: 2016
    ..The proposed studies will reveal a novel molecular mechanism mediating renal adaptation to high salt intake and provide new insights into the pathogenesis of salt-sensitive hypertension. ..
  54. Control by Oxygen of Lens Metabolism and Cataract Formation
    David Beebe; Fiscal Year: 2009
    ..This study will test our prediction that oxygen from the retina is responsible for the "normal," age- related opacification of the lens nucleus. ..
  55. Karen M Lyons; Fiscal Year: 2015
    ..This knowledge has the potential to lead to new therapeutic approaches to the treatment of OA and DDD. ..
  56. MARK ROBERT NICOLLS; Fiscal Year: 2016
    ..The proposed studies will investigate how the body's normal reparative processes resupply airways with blood vessels and how this process might be utilized to prevent airway injury. ..
  57. Kenneth Walsh; Fiscal Year: 2015
    ..With these proposed studies, we hope develop a better understanding of how endothelium functions at the interface of cardiovascular disease and metabolic dysfunction. ..
  58. Chaetocin as a Potential Therapy for Multiple Myeloma
    Keith C Bible; Fiscal Year: 2012
    ..the contributions of effects on TrxR and other reductases, histone modifying enzymes (including HDACs and HMTs), HIF1 and other targets to the cytotoxic selectivity of chaetocin;as well as further investigate mechanisms of cellular ..
  59. Molecular Basis Of Renal Cell Carcinoma Response to SU11428
    Robert J Motzer; Fiscal Year: 2011
    ..These tumor and cell line-based studies lay a foundation for further molecular studies aimed at understanding the sensitivity/resistance of RCC to SU11248. ..
  60. DAVID BENNER LOMBARD; Fiscal Year: 2014
    ..SIRT6 functions as an intestinal tumor suppressor in humans and mice, at least in part via attenuation of MYC and HIF1 signaling...
  61. Pankaj Kumar Singh; Fiscal Year: 2016
    ..Here, we hypothesize that signaling through MUC1 stabilizes HIF1??and facilitates metabolic cross-talk between epithelial and stromal components in pancreatic adenocarcinoma;thus ..
  62. Role of HIF-1a in T Cells During Sepsis
    Charles Caldwell; Fiscal Year: 2009
    ..These studies will greatly advance our knowledge of the pathophysiology of sepsis and may identify several novel potential therapeutic targets. ..
  63. SAMI NIMER MALEK; Fiscal Year: 2016
    ..Through these efforts, we have established an essential role for hypoxia-inducing factor 1 [unreadable] (HIF1 [unreadable]) in the maintenance of the stem cells of both lymphoma and leukemia...
  64. Hypoxia-inducible factors in alcoholic liver disease
    Gyongyi Szabo; Fiscal Year: 2010
    ..protein and mRNA in the livers of chronically alcohol-fed mice versus pair-fed controls correlate positively with HIF1 or HIF2 transcription factor activity and expression of downstream targets of HIF1 and HIF2 that are implicated in ..
  65. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2004
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  66. A Pilot Study of Novel Candidate Genes for Preeclampsia
    Sue Ingles; Fiscal Year: 2005
    ..While the likely severity of such bias has been debated in the epidemiologic literature, there have been no studies to assess the extent of this problem in Hispanics, one of the populations that is most likely to be affected. ..
  67. Hypoxia Signaling, Chromatin Remodeling and Nickel Carcinogenesis
    Max Costa; Fiscal Year: 2009
    ..These studies will allow us to understand the importance of hypoxia signaling and the HIF-1alpha transcription factor in promoting neoplastic cell transformation. ..