HGFAC

Summary

Gene Symbol: HGFAC
Description: HGF activator
Alias: HGFA, hepatocyte growth factor activator
Species: human

Top Publications

  1. ncbi Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII
    K Miyazawa
    Institute for Liver Research, Kansai Medical University, Osaka, Japan
    J Biol Chem 268:10024-8. 1993
  2. doi Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases
    Shoichiro Mukai
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Japan
    FEBS J 275:1003-17. 2008
  3. ncbi Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma
    Esther P M Tjin
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Blood 107:760-8. 2006
  4. ncbi Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator
    Esther P M Tjin
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 104:2172-5. 2004
  5. ncbi Activation of the zymogen of hepatocyte growth factor activator by thrombin
    T Shimomura
    Biosciences Laboratory, Mitsubishi Kasei Corp, Yokohama, Japan
    J Biol Chem 268:22927-32. 1993
  6. ncbi Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2) are potential targets in uterine leiomyosarcoma
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Int J Oncol 37:605-14. 2010
  7. pmc Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling
    Benjamin Y Owusu
    Department of Oncology, Drug Discovery Division, Southern Research, Birmingham, AL, USA
    Oncotarget 7:29492-506. 2016
  8. pmc SPINT2 Deregulation in Prostate Carcinoma
    Márcia Santos Pereira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal MSP, FP, MVP, RMR ICVS 3B s PT Government Associate Laboratory, Braga Guimarães, Portugal MSP, FP, MVP, RMR Department of Pathology GCA and Molecular Oncology Research Center RMR, Barretos Cancer Hospital, S Paulo, Brazil
    J Histochem Cytochem 64:32-41. 2016
  9. pmc Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Nicholas B Larson
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    Ann Hum Genet 79:264-74. 2015
  10. pmc Mechanisms of hepatocyte growth factor activation in cancer tissues
    Makiko Kawaguchi
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Cancers (Basel) 6:1890-904. 2014

Scientific Experts

  • C Parr
  • Minoru Kato
  • A Kummeling
  • Keiichiro Nakamura
  • N H Choi-Miura
  • Motoko Sasaki
  • Keiji Miyazawa
  • Hiroaki Kataoka
  • Jiang Cao
  • Osamu Nagakawa
  • Eva Schmelzer
  • Rob Zachow
  • Xuan Zhang
  • Jean Luc C Mougeot
  • J S van Adelsberg
  • K F Wader
  • M Spaargaren
  • T Kaido
  • Takashi Watanabe
  • H Itoh
  • Koji Suzuki
  • Daniel Kirchhofer
  • Rajkumar Ganesan
  • Charles Eigenbrot
  • Esther P M Tjin
  • Makiko Kawaguchi
  • Tsuyoshi Fukushima
  • Steven Shia
  • Bin Fan
  • Yan Wu
  • Benjamin Y Owusu
  • Márcia Santos Pereira
  • T Hayashi
  • Lidija Klampfer
  • Sylvain Marchand-Adam
  • Nathan P Zwintscher
  • Zhenfu Han
  • Nicholas B Larson
  • Soonyean Hwang
  • Robert A Lazarus
  • Jonathan D Mosley
  • Arivusudar Marimuthu
  • Patrick W B Derksen
  • Steven T Pals
  • Yun Chao Meng
  • Yukinori Yamagata
  • Tobias Koschubs
  • Tsuyoshi Ohki
  • Chiduru Yamamoto
  • Sophie Phin
  • T Shimomura
  • Michael T Lipari
  • Ciara O'Reilly
  • Shoichiro Mukai
  • Aurelie Fabre
  • T Hamada
  • Yoshihiko Kitajima
  • Lydia Santell
  • Paul Soler
  • Jorge Kather
  • Wei Ching Liang
  • Bruno Crestani
  • E C Gabazza
  • H Kamada
  • J Nishioka
  • Shunro Uchinokura
  • Jonathan A Roling
  • Yutaka Akiyama
  • Yukio Osada
  • Mehmet Uzumcu
  • Hiroyuki Tanaka
  • Weiping Su
  • Jennifer Stamos
  • Masamichi Yamauchi
  • Koki Nagaike
  • Aída Alejandra Segura-Flores
  • Takeshi Hori
  • Phanindra K M Venukadasula
  • Ahmed Samy
  • Shashikumar K Salgar
  • Murad Jabir
  • Robert A Galemmo
  • E M G Campbell
  • Puja M Shah
  • Marta Viana-Pereira
  • Larry J Ross
  • Partha Karmakar
  • Gisele Caravina de Almeida
  • James W Janetka
  • Justin A Maykel

Detail Information

Publications93

  1. ncbi Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII
    K Miyazawa
    Institute for Liver Research, Kansai Medical University, Osaka, Japan
    J Biol Chem 268:10024-8. 1993
    ..These domains may be involved in the conversion of the precursor to the active form of HGF activator...
  2. doi Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases
    Shoichiro Mukai
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Japan
    FEBS J 275:1003-17. 2008
    b>Hepatocyte growth factor activator (HGFA) is a serine protease and a potent activator of prohepatocyte growth factor/scatter factor (pro-HGF/SF), a multifunctional growth factor that is critically involved in tissue morphogenesis, ..
  3. ncbi Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma
    Esther P M Tjin
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Blood 107:760-8. 2006
    ..of DLBCL, HGF is provided by macrophages, whereas DLBCL cells themselves produce the serine protease HGF activator (HGFA), which autocatalyzes HGF activation...
  4. ncbi Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator
    Esther P M Tjin
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 104:2172-5. 2004
    ..Here, we show that malignant MM plasma cells convert HGF into its active form and secrete HGF-activator (HGFA), a serine protease specific for HGF activation...
  5. ncbi Activation of the zymogen of hepatocyte growth factor activator by thrombin
    T Shimomura
    Biosciences Laboratory, Mitsubishi Kasei Corp, Yokohama, Japan
    J Biol Chem 268:22927-32. 1993
    b>Hepatocyte growth factor activator (HGF activator) is a serine protease which converts single-chain HGF to the active two-chain form...
  6. ncbi Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2) are potential targets in uterine leiomyosarcoma
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Int J Oncol 37:605-14. 2010
    b>Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2) are Kunitz-type serine protease inhibitors that have a broad inhibitory spectrum against serine proteases...
  7. pmc Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling
    Benjamin Y Owusu
    Department of Oncology, Drug Discovery Division, Southern Research, Birmingham, AL, USA
    Oncotarget 7:29492-506. 2016
    ..processing of pro-HGF to its active form by one of the three serine proteases, matriptase, hepsin or HGF activator (HGFA)...
  8. pmc SPINT2 Deregulation in Prostate Carcinoma
    Márcia Santos Pereira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal MSP, FP, MVP, RMR ICVS 3B s PT Government Associate Laboratory, Braga Guimarães, Portugal MSP, FP, MVP, RMR Department of Pathology GCA and Molecular Oncology Research Center RMR, Barretos Cancer Hospital, S Paulo, Brazil
    J Histochem Cytochem 64:32-41. 2016
    SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase...
  9. pmc Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Nicholas B Larson
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    Ann Hum Genet 79:264-74. 2015
    ..E299K) as well as four variants (rs16844364, rs4690098, rs114303452, rs3748034) within or in proximity to HGFAC. We also identified two significant ethnicity-specific gene-level associations (A1BG in African Americans; FASN in ..
  10. pmc Mechanisms of hepatocyte growth factor activation in cancer tissues
    Makiko Kawaguchi
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Cancers (Basel) 6:1890-904. 2014
    ..Several serine proteases are reported to convert pro-HGF/SF to mature HGF/SF and among these, HGF activator (HGFA) and matriptase are the most potent activators...
  11. ncbi CD44-independent hepatocyte growth factor/c-Met autocrine loop promotes malignant peripheral nerve sheath tumor cell invasion in vitro
    Weiping Su
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Glia 45:297-306. 2004
    ..However, HGF/c-Met autocrine activity requires the presence of a serine protease, the HGF activator (HGFA), and, in some cells, the CD44 transmembrane glycoprotein...
  12. doi Hepatic gene expression and plasma albumin concentration related to outcome after attenuation of a congenital portosystemic shunt in dogs
    Anne Kummeling
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, P O Box 80154, 3508 TD Utrecht, The Netherlands
    Vet J 191:383-8. 2012
    ..Albumin, methionine adenosyltransferase 2α (MAT2α) and HGF activator (HGFac) were positively associated with complete recovery after CPSS attenuation using multivariate statistical analyses...
  13. pmc Hepatocyte growth factor, hepatocyte growth factor activator and arginine in a rat fulminant colitis model
    Nathan P Zwintscher
    Department of Surgery, Madigan Army Medical Center, Tacoma, WA, USA
    Ann Med Surg (Lond) 7:97-103. 2016
    ..HGF) has been shown to decrease the symptoms of inflammatory bowel disease (IBD) but the effect of its activator, HGFA, is not well characterized. Arginine reduces effects of oxidative stress but its effect on IBD is not well known...
  14. doi Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor
    Keiji Miyazawa
    Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    FEBS J 277:2208-14. 2010
    ..mechanisms of HGF activity has revealed that a blood coagulation factor XII-like serine protease, hepatocyte growth factor activator, efficiently converts HGF from the latent form to the active form...
  15. ncbi Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells
    C Parr
    Metastasis Research Group, Department of Surgery, University of Wales College of Medicine, Cardiff, CF14 4XN, UK
    Int J Oncol 19:857-63. 2001
    ..present study examined the expression of HGF/SF, HGFA, the two inhibitors to HGFA action known as hepatocyte growth factor activator inhibitors type 1 and 2 (HAI-1 and HAI-2), and the HGF/SF receptor, c-Met...
  16. ncbi Expressions of molecules associated with hepatocyte growth factor activation after hepatectomy in liver cirrhosis
    Toshimi Kaido
    Department of Surgery, Otsu Municipal Hospital, Otsu, Japan
    Hepatogastroenterology 51:547-51. 2004
    The activation pathway of hepatocyte growth factor (HGF), including HGF activator (HGFA) and HGFA inhibitor-1, 2 (HAI-1, 2), has recently been clarified...
  17. ncbi [Hepatocyte growth factor (HGF) and its therapeutic applications]
    Aída Alejandra Segura-Flores
    Instituto de Biología Molecular y Terapia Génica, Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco
    Rev Gastroenterol Mex 69:243-50. 2004
    ..The hepatocyte growth factor activator (HGFA) is the principal activator of HGF...
  18. ncbi Hexavalent chromium reduces larval growth and alters gene expression in mummichog (Fundulus heteroclitus)
    Jonathan A Roling
    Biological Sciences Department, University of Texas at El Paso, El Paso, Texas 79912, USA
    Environ Toxicol Chem 25:2725-33. 2006
    ..Hexavalent chromium altered the expression of 10 genes in adult liver, including HGFA, H-FABP, and complement component C3-2. Many of these genes also are involved in energy metabolism...
  19. ncbi Expression of hepatocyte growth factor activator inhibitor type 1 in endothelial cells
    Yutaka Akiyama
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Hum Cell 19:91-7. 2006
    b>Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is an integral membrane Kunitz-type serine proteinase inhibitor initially identified as a potent inhibitor of hepatocyte growth factor activator (HGFA)...
  20. doi Hepatocyte growth factor activator inhibitor type 1 inhibits protease activity and proteolytic activation of human airway trypsin-like protease
    Minoru Kato
    Advanced Medical Research Laboratory, Mitsubishi Tanabe Pharma Corporation, Kamoshida cho, Aoba ku, Yokohama 227 0033, Japan
    J Biochem 151:179-87. 2012
    b>Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a Kunitz-type transmembrane serine protease inhibitor initially identified as a potent inhibitor of hepatocyte growth factor activator (HGFA), a serine protease that converts ..
  21. doi α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer
    Zhenfu Han
    Department of Biochemistry and Molecular Biophysics, Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 S Euclid Ave, Saint Louis, MO, 63110, USA
    ChemMedChem 11:585-99. 2016
    Upregulation of the HGF and MSP growth-factor processing serine endopeptidases HGFA, matriptase and hepsin is correlated with increased metastasis in multiple tumor types driven by c-MET or RON kinase signaling...
  22. pmc Epigenetic Silencing of SPINT2 Promotes Cancer Cell Motility via HGF-MET Pathway Activation in Melanoma
    Soonyean Hwang
    Department of Dermatology, Boston University School of Medicine, Boston, Massachussetts, USA
    J Invest Dermatol 135:2283-91. 2015
    ..study, we identified SPINT2 (serine peptidase inhibitor Kunitz type 2), a proteolytic inhibitor of hepatocyte growth factor activator (HGFA), which has a significant role in the suppression of the HGF-MET pathway and malignant ..
  23. pmc Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations
    Jonathan D Mosley
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 9:e100322. 2014
    ..F5,rs6031), seizures/convulsions (GPR98,rs13157270), macular degeneration (CNGB3,rs3735972), and GI bleeding (HGFAC,rs16844401)...
  24. ncbi Paradoxically enhanced immunoreactivity of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in cancer cells at the invasion front
    Koki Nagaike
    Second Department of Pathology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Cancer Sci 95:728-35. 2004
    We have previously demonstrated significantly decreased immunoreactivity of hepatocyte growth factor activator inhibitor type 1 (HAI-1), an integral membrane protein that exhibits potent inhibitory activity against hepatocyte growth ..
  25. ncbi Defect of pro-hepatocyte growth factor activation by fibroblasts in idiopathic pulmonary fibrosis
    Sylvain Marchand-Adam
    INSERM Unit 700, Institut National de la Sante et de la Recherche Medicale, Faculte Xavier Bichat, Paris, France
    Am J Respir Crit Care Med 174:58-66. 2006
    ..Pro-HGF activation to HGF is subjected to regulation by its activator (HGFA), a serine protease, and HGFA-specific inhibitors (HAI-1 and HAI-2)...
  26. ncbi Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator
    Esther P M Tjin
    Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 175:2807-13. 2005
    ..study we have examined the expression of regulatory components of the HGF/MET pathway, including HGF activator (HGFA), within the secondary lymphoid organ microenvironment...
  27. ncbi Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo
    Shunro Uchinokura
    Second Department of Pathology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Int J Cancer 118:583-92. 2006
    ..HGF activator (HGFA) is a serine proteinase responsible for the activation of proform of HGF/SF (proHGF/SF)...
  28. doi Identification of head and neck squamous cell carcinoma biomarker candidates through proteomic analysis of cancer cell secretome
    Arivusudar Marimuthu
    Institute of Bioinformatics, International Technology Park, Bangalore 560066, India
    Biochim Biophys Acta 1834:2308-16. 2013
    ..identified several novel secreted proteins in HNSCC including olfactomedin-4, OLFM4 (12-fold) and hepatocyte growth factor activator, HGFA (5-fold)...
  29. doi [Activation of hepatocyte growth factor-induced apoptosis in hepatic stellate cells]
    Yun Chao Meng
    Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
    Zhonghua Gan Zang Bing Za Zhi 20:698-702. 2012
    ..induced in rat hepatic stellate cells (HSCs) in response to activation of the hepatocyte growth factor (HGF) by hepatocyte growth factor activator (HGFA) by using a co-culture system of bone marrow mesenchymal stem cells (BMSCs) and HSCs.
  30. pmc Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels
    Yukinori Yamagata
    Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Gastrointest Liver Physiol 303:G1254-61. 2012
    ..DMP-777, a parietal cell ablating reagent, was administered to HGF activator (HGFA)-deficient mice and wild-type mice...
  31. ncbi Activation of hepatocyte growth factor in monkey stomach following gastric mucosal injury
    Takeshi Hori
    Second Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 889 1601, Miyazaki, Kiyotake, Japan
    J Gastroenterol 39:133-9. 2004
    ..HGF is produced as a single-chain precursor (pro-HGF) and functions after activation by HGF activator (HGFA)...
  32. doi Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells
    Tsuyoshi Ohki
    Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
    Biochem Biophys Res Commun 425:619-24. 2012
    ..Expression of the gene encoding hepatocyte growth factor (HGF) activator (Hgfac), a serine protease that efficiently activates HGF, was decreased in HNF1α KD-MIN6 cells...
  33. ncbi Hepatocyte growth factor activator inhibitor types 1 and 2 are expressed by tubular epithelium in kidney and down-regulated in renal cell carcinoma
    Masamichi Yamauchi
    Second Department of Pathology, Miyazaki Medical College, Kiyotake, Japan
    J Urol 171:890-6. 2004
    ..HGF is secreted as an inactive proform and it must be activated to initiate MET signaling. HGF activator (HGFA) activates pro-HGF in injured tissue...
  34. doi Allosteric antibody inhibition of human hepsin protease
    Tobias Koschubs
    Gene Center Munich, Department of Biochemistry, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Biochem J 442:483-94. 2012
    ..The unique allosteric mode of inhibition of hH35 is distinct from the recently described HGFA (hepatocyte growth factor activator) allosteric antibody inhibition...
  35. ncbi Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment
    H Kataoka
    Second Department of Pathology, Miyazaki Medical College, Kihara, Kiyotake, Miyazaki 889 1692, Japan
    J Biol Chem 275:40453-62. 2000
    b>Hepatocyte growth factor activator (HGFA) is responsible for proteolytic activation of the precursor form of hepatocyte growth factor in injured tissues...
  36. ncbi Hepatocyte growth factor in gingival crevicular fluid and the distribution of hepatocyte growth factor-activator in gingival tissue from adult periodontitis
    K Kakimoto
    Department of Biochemistry, Kagoshima University Dental School, 35 1 Sakuragaoka 8, 890 8544, Kagoshima, Japan
    Arch Oral Biol 47:655-63. 2002
    ..HGF-activator (HGFA), which converts inactive pro-HGF to active mature HGF, was detected in gingival epithelial cells by immunostaining...
  37. ncbi Serum hepatocyte growth factor activator inhibitor type I (HAI-I) and type 2 (HAI-2) in prostate cancer
    Osamu Nagakawa
    Toyama Medical and Pharmaceutical University, Department of Urology, Toyama, Japan
    Prostate 66:447-52. 2006
    b>Hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2) are Kunitz-type serine protease inhibitors for hepatocyte growth factor activator (HGFA)...
  38. ncbi Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator
    T Hayashi
    Department of Molecular Pathobiology, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
    J Thromb Haemost 5:1477-85. 2007
    Hepatocyte growth factor (HGF) plays an important role in tissue repair and regeneration. HGF activator (HGFA), a factor XIIa-like serine protease, activates HGF precursor to HGF...
  39. ncbi Protein C inhibitor regulates hepatocyte growth factor activator-mediated liver regeneration in mice
    T Hamada
    Department of Molecular Pathobiology, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu City, Mie 514 8507, Japan
    Gut 57:365-73. 2008
    ..that human protein C inhibitor (PCI), a major inhibitor of activated protein C (APC), inhibits hepatocyte growth factor activator (HGFA) by forming HGFA-PCI complexes in vitro...
  40. ncbi The hepatocyte growth factor system as a regulator of female and male gonadal function
    Rob Zachow
    Department of Physiology and Biophysics, Robert Wood Johnson Medical School UMDNJ, 675 Hoes Lane West, Piscataway, New Jersey 08854, USA
    J Endocrinol 195:359-71. 2007
    The hepatocyte growth factor (HGF) system comprises HGF, its receptor (the c-met tyrosine kinase), HGF activator (HGFA) protein, and HGFA inhibitor (HAI)...
  41. ncbi Clinical and histomorphometric characteristics of three different families with hereditary gingival fibromatosis
    Jorge Kather
    Department of Periodontology, University of Taubate, Sao Paulo, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:348-52. 2008
    ..To examine the histomorphologic and histomorphometric features of tissue from 3 unrelated families with hereditary gingival fibromatosis (HGF)...
  42. pmc Structural insight into distinct mechanisms of protease inhibition by antibodies
    Yan Wu
    Departments of Antibody Engineering and Protein Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 104:19784-9. 2007
    ..we determined the structures of two antibodies in complex with the trypsin-like hepatocyte growth-factor activator (HGFA)...
  43. doi Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1)
    Charles Eigenbrot
    Department of Structural Biology, Genentech, Inc, South San Francisco, CA 94080, USA
    FEBS J 277:2215-22. 2010
    The trypsin-like serine protease hepatocyte growth factor activator (HGFA) undergoes proteolytic activation during blood coagulation, resulting in a 34 kDa 'short form', consisting mainly of the protease domain...
  44. doi Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer
    Yoshihiko Kitajima
    Department of Surgery, Saga University Faculty of Medicine, Saga, B49 8501 Japan
    Cancer Sci 99:1341-7. 2008
    Hepatocyte growth facor activator (HGFA) is a serine protease that converts hepatocyte growth factor (HGF) into its active form...
  45. doi Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor
    Koji Suzuki
    Department of Molecular Pathobiology, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
    FEBS J 277:2223-9. 2010
    ..Recently, PCI was also found to form a complex with the serine protease hepatocyte growth factor activator (HGFA), inhibiting the HGFA-catalyzed activation of the single-chain hepatocyte growth factor ..
  46. doi Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo
    Hiroaki Kataoka
    Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    FEBS J 277:2230-7. 2010
    b>Hepatocyte growth factor activator (HGFA) is a serine protease initially identified as a potent activator of hepatocyte growth factor/scatter factor...
  47. pmc Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma
    K F Wader
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Haematol 81:380-3. 2008
    ..We aimed to examine the levels of the most potent activator, the hepatocyte growth factor activator (HGFA), in serum and bone marrow plasma of patients with multiple myeloma.
  48. doi Hepatocyte growth factor (HGF) and the satellite cell response following muscle lengthening contractions in humans
    Ciara O'Reilly
    Department of Kinesiology, Ivor Wynne Centre, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Muscle Nerve 38:1434-42. 2008
    ..of satellite cell (SC) activation and protein expression of hepatocyte growth factor (HGF), HGF activator (HGFA), HGFA inhibitor-1 (HAI-1), and HGFA inhibitor-2 (HAI-2) in human skeletal muscle, as well as serum HGF following a ..
  49. pmc Hepatocyte growth factor system in the mouse uterus: variation across the estrous cycle and regulation by 17-beta-estradiol and progesterone
    Xuan Zhang
    Department of Obstetrics and Gynecology, University of Kansas School of Medicine, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Biol Reprod 82:1037-48. 2010
    ..The present study aimed to investigate the changes of HGF, MET, and HGF activator (HGFA) expression in the uterine endometrium during the estrous cycle in mice and to explore estrogen and progesterone ..
  50. doi Effect of human patient plasma ex vivo treatment on gene expression and progenitor cell activation of primary human liver cells in multi-compartment 3D perfusion bioreactors for extra-corporeal liver support
    Eva Schmelzer
    Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Biotechnol Bioeng 103:817-27. 2009
    ..HGF was detected in scattered cells located close to vascular-like structures, expression of HGFA and c-Met was assigned to biliary cells and hepatocytes...
  51. doi Significance of portal venous VEGF during liver regeneration after hepatectomy
    Chiduru Yamamoto
    Department of Hepatobiliary and Pancreatic Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    J Surg Res 159:e37-43. 2010
    ....
  52. doi Proteolytic activation of pro-macrophage-stimulating protein by hepsin
    Rajkumar Ganesan
    Department of Early Discovery Biochemistry, Genentech, Inc, 1 DNA Way, MS 27, South San Francisco, CA 94080, USA
    Mol Cancer Res 9:1175-86. 2011
    ..site Arg(483)-Val(484) with superior efficiency compared with the known activators MT-SP1 and hepatocyte growth factor activator (HGFA). At least 50% of pro-MSP was processed within 1 hour at a hepsin concentration of 2...
  53. ncbi Hepatocyte growth factor activation inhibitors - therapeutic potential in cancer
    Christian Parr
    Cardiff University, UK
    Anticancer Agents Med Chem 10:47-57. 2010
    ..pro-HGF into the biologically active form of HGF, although the two main factors responsible are HGF activator (HGFA) and matriptase...
  54. doi Unraveling the allosteric mechanism of serine protease inhibition by an antibody
    Rajkumar Ganesan
    Department of Protein Engineering, Genentech, Inc, South San Francisco, CA 94080, USA
    Structure 17:1614-24. 2009
    ..Here we report the 2.35 A resolution structure of the trypsin-like serine protease hepatocyte growth factor activator (HGFA) in complex with the allosteric antibody Ab40, a potent inhibitor of HGFA catalytic activity...
  55. doi Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein
    Makiko Kawaguchi
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Japan
    FEBS J 276:3481-90. 2009
    ..In this article, we report that hepatocyte growth factor activator (HGFA), a serum proteinase which activates hepatocyte growth factor in response to tissue injury, ..
  56. doi Imbalance in the pro-hepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice
    Sophie Phin
    INSERM Unit 700, Faculte Xavier Bichat, Paris, France
    Am J Respir Cell Mol Biol 42:286-93. 2010
    ..Activation of pro-HGF to HGF is regulated by the HGF activator (HGFA), a serine protease, and a specific inhibitor (HGFA inhibitor-1, HAI-1)...
  57. ncbi Detection of a novel plasma serine protease during purification of vitamin K-dependent coagulation factors
    A Hunfeld
    Paul Ehrlich Institut, Langen, Germany
    FEBS Lett 456:290-4. 1999
    ..NH2-terminal sequence analysis revealed identity to the deduced amino acid sequence of HGFA-like mRNA...
  58. ncbi Hepatocyte growth factor (HGF), HGF activator, and c-Met in synovial tissues in rheumatoid arthritis and osteoarthritis
    M Nagashima
    Department of Joint Disease and Rheumatism, Nippon Medical School, Tokyo, Japan
    J Rheumatol 28:1772-8. 2001
    ..Its actions are dependent on activation by HGF activator (HGFA) and its binding to a specific HGF receptor (c-Met)...
  59. ncbi Changes in gene expression during progression of ovarian carcinoma
    J Tapper
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, P O Box 140, Haartmaninkatu 2, FIN 00029 HUS, Helsinki, Finland
    Cancer Genet Cytogenet 128:1-6. 2001
    ..Other changes in carcinoma were upregulation of MET and Ne-dlg, and downregulation of HGFAC, desmin, and PDGFA...
  60. ncbi Identification of the substrates for plasma hyaluronan binding protein
    N H Choi-Miura
    Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Biol Pharm Bull 24:140-3. 2001
    ..protein (PHBP) is a novel serine protease, which has an amino acid sequence homology to that of hepatocyte growth factor activator (HGFA), and has a similar domain structure to that of urinary plasminogen activator (u-PA), found in ..
  61. ncbi Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta
    H Kataoka
    Second Department of Pathology, Miyazaki Medical College, Kiyotake, Japan
    Histochem Cell Biol 114:469-75. 2000
    ..The HGF activator inhibitor type 1 (HAI-1) was identified as a potent inhibitor of HGF activator (HGFA), a serine proteinase that is responsible for the activation of HGF in vivo...
  62. ncbi Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma
    H Kataoka
    The Second Department of Pathology, Miyazaki Medical College, Kiyotake, Japan
    Cancer Res 60:6148-59. 2000
    ..enhanced by thrombin treatment but was inhibited significantly by a neutralizing antibody against HGF activator (HGFA), a factor XIIa-like serine proteinase believed to be expressed mainly in the liver...
  63. ncbi Activation of hepatocyte growth factor (HGF) by endogenous HGF activator is required for metanephric kidney morphogenesis in vitro
    J van Adelsberg
    Columbia University College of Physicians and Surgeons, Department of Medicine, New York, New York 10032, USA
    J Biol Chem 276:15099-106. 2001
    ..We show here that a serine protease specific for HGF, HGF activator (HGFA), is expressed and activated by the ureteric bud of the developing kidney in vivo and in vitro...
  64. ncbi Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes
    H Itoh
    Second Department of Pathology, Miyazaki Medical College, Miyazaki, Japan
    Eur J Biochem 267:3351-9. 2000
    b>Hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2) are recently discovered Kunitz-type serine protease inhibitors which can be purified and cloned from human stomach cancer cell line MKN45 as specific ..
  65. ncbi Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract
    H Itoh
    Second Department of Pathology, Miyazaki Medical College, Miyazaki, Japan
    Biochim Biophys Acta 1491:295-302. 2000
    A cDNA encoding mouse hepatocyte growth factor activator (HGFA) has been cloned by RT-PCR, based on the screening result from the database of expressed sequence tags...
  66. ncbi Mouse hepatocyte growth factor (HGF) activator inhibitor type 2 lacking the first Kunitz domain potently inhibits the HGF activator
    Hiroaki Kataoka
    Second Department of Pathology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, 889 1692, Japan
    Biochem Biophys Res Commun 290:1096-100. 2002
    b>Hepatocyte growth factor activator inhibitor type 2 (HAI-2) is a serine proteinase inhibitor containing two Kunitz-type inhibitor domains, initially identified as a potent inhibitor of hepatocyte growth factor activator (HGFA)...
  67. ncbi Hepatocyte growth factor activator inhibitor type 2 lacking the first Kunitz-type serine proteinase inhibitor domain is a predominant product in mouse but not in human
    H Itoh
    Second Department of Pathology, Miyazaki Medical College, Kihara, Miyazaki, Kiyotake, 889 1692, Japan
    Biochem Biophys Res Commun 255:740-8. 1999
    b>Hepatocyte growth factor activator inhibitor type 2 (HAI-2) is a new Kunitz-type serine protease inhibitor, which is purified and cloned from human stomach cancer cell line MKN45...
  68. ncbi White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues
    T Yamada
    Department of Internal Medicine and Health Care, Fukuoka University, Fukuoka, Japan
    Exp Neurol 153:60-4. 1998
    ..A HGF activator (HGFA) has been identified as a key enzyme that regulates the activity of HGF in vivo...
  69. ncbi Cloning of the cDNA for a mouse homologue of human PHBP: a novel hyaluronan-binding protein
    K Hashimoto
    Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Biol Pharm Bull 20:1127-30. 1997
    ..Like human PHBP, the amino acid sequence predicted from the nucleotide sequence of mouse PHBP cDNA exhibited significant homology to that of human hepatocyte growth factor activator (HGFA).
  70. ncbi Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor
    T Kawaguchi
    Research Center, Mitsubishi Chemical Corp, Aoba ku, Yokohama 227, Japan
    J Biol Chem 272:27558-64. 1997
    ..Because HAI-2 and HAI-1 are potent inhibitors specific for HGF activator, they may be involved in regulation of proteolytic activation of HGF in injured tissues...
  71. ncbi Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor
    T Shimomura
    Research Center, Mitsubishi Chemical Corp, Aoba ku, Yokohama 227, Japan
    J Biol Chem 272:6370-6. 1997
    ..These results suggest that the inhibitor may be produced as a membrane-associated form and secreted by the producing cells as a proteolytically truncated form...
  72. ncbi Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator
    N H Choi-Miura
    Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo
    J Biochem 119:1157-65. 1996
    ..from the nucleotide sequence of the cloned PHBP cDNA exhibited significant homology to that of hepatocyte growth factor activator (HGFA)...
  73. ncbi Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator
    K Miyazawa
    Institute for Liver Research, Kansai Medical University, Moriguchi, Osaka 570, Japan
    J Biol Chem 271:3615-8. 1996
    ..We have previously purified and characterized HGF activator (HGFA), a serum-derived serine protease that efficiently activates single-chain HGF in vitro...
  74. ncbi Structure and function of hepatocyte growth factor
    T Nakamura
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Prog Growth Factor Res 3:67-85. 1991
    ..Thus, HGF may play an important role as a paracrine or endocrine mediator through an epithelial-mesenchymal interaction in wound-healing, tissue or organ regeneration, morphogenesis and carcinogenesis...
  75. ncbi Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B
    Steven Shia
    Department of Protein Engineering, Genentech, Inc, South San Francisco, CA 94080, USA
    J Mol Biol 346:1335-49. 2005
    b>Hepatocyte growth factor activator (HGFA) is a serine protease that converts hepatocyte growth factor (HGF) into its active form...
  76. ncbi Augmented expression of hepatocytes growth factor activator inhibitor type 1 (HAI-1) in intrahepatic small bile ducts in primary biliary cirrhosis
    Motoko Sasaki
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, 920 8640, Japan
    Virchows Arch 449:462-71. 2006
    ..Given that related factors of the hepatocyte growth factor (HGF) such as HGF activator (HGFA) and HGFA inhibitor type 1 (HAI-1) participate in the repair of injured gastrointestinal mucosa, we investigated ..
  77. ncbi Immunolocalization of the hepatocyte growth factor (HGF) system in the rat ovary and the anti-apoptotic effect of HGF in rat ovarian granulosa cells in vitro
    Mehmet Uzumcu
    Department of Animal Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    Reproduction 132:291-9. 2006
    ..Immunohistochemistry was used to investigate the distribution of HGF, c-met, and HGF activator (HGFA) protein during folliculogenesis in equine chorionic gonadotropin (eCG)-primed rats...
  78. ncbi Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cells
    Christian Parr
    Metastasis and Angiogenesis Research Group, Department of Surgery, Wales College of Medicine, Cardiff University, UK
    Int J Cancer 119:1176-83. 2006
    ..HGF activator (HGFA), matriptase, urokinase-type plasminogen activator and hepsin are the main factors responsible for converting pro-..
  79. ncbi Gene expression profiling of ovarian tissues for determination of molecular pathways reflective of tumorigenesis
    Jean Luc C Mougeot
    Cannon Research Center, Department of Research Services, Carolinas Medical Center, P O Box 32861, Charlotte, NC 28232 2861, USA
    J Mol Biol 358:310-29. 2006
    ..performed on a limited set of ovarian tissues with various pathological diagnoses using Human Genome Focus Array (HGFA) for the detection of approximately 8500 human transcripts...
  80. ncbi Changes in plasma levels of hepatocyte growth factor and its associated factors during pregnancy
    Takashi Watanabe
    Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi, Japan
    J Obstet Gynaecol Res 32:10-4. 2006
    ..We conducted this study to evaluate the changes in plasma concentrations of HGF and its associated factors during normal pregnancy...
  81. ncbi A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture
    T Shimomura
    Biosciences Laboratory, Mitsubishi Kasei Corp, Yokohama, Japan
    Cytotechnology 8:219-29. 1992
    ..The results of N-terminal amino acid sequence analysis and inhibitor selectivity suggested that this protease was a novel serine protease originating from fetal bovine serum...
  82. ncbi [Effect of HAI-1 over-expression on in vitro growth and migration/motility of SW620 cells]
    Jiang Cao
    Sir Run Run Shaw Clinical Research Institute, Zhejiang University, Hangzhou 310016, China
    Shi Yan Sheng Wu Xue Bao 38:183-9. 2005
    b>Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is an effective inhibitor for hepatocyte growth factor activator (HGFA) and serine protease Matriptase, and is involved in HGF/c-Met signaling pathway by regulating activities of ..
  83. ncbi Serum hepatocyte growth factor activator (HGFA) in benign prostatic hyperplasia and prostate cancer
    Osamu Nagakawa
    Department of Urology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur Urol 48:686-90. 2005
    b>Hepatocyte growth factor activator (HGFA) is responsible for proteolytic activation of the precursor form of hepatocyte growth factor (HGF). We attempted to clarify whether serum levels of HGFA could be used as a marker for prostate cancer...
  84. ncbi Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth
    Bin Fan
    Department of Protein Engineering, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Dev Biol 303:222-30. 2007
    b>Hepatocyte growth factor activator inhibitor-1 (HAI-1) is a membrane-associated Kunitz-type serine protease inhibitor that regulates cell surface and extracellular serine proteases involved in tissue remodeling and tumorigenesis, such as ..
  85. ncbi Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice
    Hiroshi Itoh
    Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Gastroenterology 127:1423-35. 2004
    b>Hepatocyte growth factor activator (HGFA) is a serum proteinase that specifically converts an inactive single-chain form of hepatocyte growth factor (HGF) into an active 2-chain form...
  86. ncbi The hepatocyte growth factor regulatory factors in human breast cancer
    Christian Parr
    Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Clin Cancer Res 10:202-11. 2004
    ..is produced as an inactive precursor called pro-HGF, which requires proteolytic conversion, by HGF activator (HGFA) and matriptase, to evoke a biological response...
  87. ncbi Immunohistochemical localization of hepatocyte growth factor activator (HGFA) in developing mouse liver tissues. Heterogeneous distribution of HGFA protein
    Ichiei Iida
    Institute of Organ Transplants, Reconstructive Medicine and Tissue Engineering, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    J Histochem Cytochem 51:1139-49. 2003
    b>Hepatocyte growth factor activator (HGFA) can activate the single-chain hepatocyte growth factor (HGF) required for embryonic development...
  88. ncbi Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 8
    E M G Campbell
    USDA, ARS, U S Meat Animal Research Center, Clay Center, NE 68933, USA
    J Anim Sci 81:1706-14. 2003
    ..Two genes were assigned since they were present in clones that contained mapped markers (HGFAC and HMX1)...
  89. ncbi Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1
    Daniel Kirchhofer
    Department of Physiology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 278:36341-9. 2003
    b>Hepatocyte growth factor activator inhibitor-1 (HAI-1) is an integral membrane protein expressed on epithelial cells and contains two extracellular Kunitz domains (N-terminal KD1 and C-terminal KD2) known to inhibit trypsin-like serine ..
  90. ncbi Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor
    Hiroaki Kataoka
    Second Department of Pathology, Miyazaki Medical College, Miyazaki, Japan
    Cancer Metastasis Rev 22:223-36. 2003
    ..The HGF activator (HGFA) is a coagulation factor XII-like serine proteinase critically involved in this process in injured tissues ..
  91. ncbi Hepatocyte growth factor (HGF) system in gingiva: HGF activator expression by gingival epithelial cells
    Mitsuhiro Ohshima
    Department of Biochemistry, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    J Oral Sci 44:129-34. 2002
    ..secreted as an inactive form (proHGF), and converted to an active form by serine proteases such as HGF activator (HGFA), extracellular processing of proHGF is presumed to be critical in the regulation of HGF activity...
  92. ncbi Expression of a hepatocyte growth-factor activator protein in turkey (Meleagris gallopavo) deferent duct epithelial cells
    D R Holsberger
    Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
    Comp Biochem Physiol B Biochem Mol Biol 132:769-77. 2002
    ..5 and 61.7% identity with murine and human hepatocyte growth-factor activator (HGFA) precursor, respectively...
  93. ncbi Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator
    K Miyazawa
    Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan
    Eur J Biochem 258:355-61. 1998
    The organization and structure of the gene coding for hepatocyte growth factor activator (HGFA) have been determined by isolation of unique clones from a human genomic library...

Research Grants1

  1. Hepatocyte growth factor activator and its inhibitors in mouse uterus
    Xuan Zhang; Fiscal Year: 2008
    ..HGF activator (HGFA) is a serine protease and is most potent in processing HGF activation in vivo, but no information is available ..