HES7

Summary

Gene Symbol: HES7
Description: hes family bHLH transcription factor 7
Alias: SCDO4, bHLHb37, transcription factor HES-7, bHLH factor Hes7, class B basic helix-loop-helix protein 37, hHes7, hairy and enhancer of split 7
Species: human

Top Publications

  1. ncbi Instability of Hes7 protein is crucial for the somite segmentation clock
    Hiromi Hirata
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Genet 36:750-4. 2004
  2. ncbi Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis
    Xu Sheng Qiu
    Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
    Stud Health Technol Inform 176:52-5. 2012
  3. ncbi Oscillations, clocks and segmentation
    Yasumasa Bessho
    Institute for Virus Research Kyoto University Shogoin Kawahara, Sakyo ku Kyoto 606 8507, Japan
    Curr Opin Genet Dev 13:379-84. 2003
  4. ncbi Mesp-family genes are required for segmental patterning and segmental border formation
    Yumiko Saga
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Adv Exp Med Biol 638:113-23. 2008
  5. ncbi Ultradian oscillators in somite segmentation and other biological events
    R Kageyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Cold Spring Harb Symp Quant Biol 72:451-7. 2007
  6. pmc Supt20 is required for development of the axial skeleton
    Sunita Warrier
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Dev Biol . 2016
  7. doi 3'-UTR-dependent regulation of mRNA turnover is critical for differential distribution patterns of cyclic gene mRNAs
    Yasuhide Nitanda
    Laboratory of Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Japan
    FEBS J 281:146-56. 2014
  8. pmc The transcriptome of utricle hair cell regeneration in the avian inner ear
    Yuan Chieh Ku
    Department of Genetics and Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110
    J Neurosci 34:3523-35. 2014
  9. doi The roles and mechanism of ultradian oscillatory expression of the mouse Hes genes
    Yukiko Harima
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan Japan Science and Technology Agency, Core Research for Evolutional Science and Technology CREST, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
    Semin Cell Dev Biol 34:85-90. 2014
  10. doi Visualization of Notch signaling oscillation in cells and tissues
    Hiromi Shimojo
    Institute for Virus Research and World Premier International Research Initiative Institute for Integrated Cell Material Sciences WPI iCeMS, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto, 606 8507, Japan
    Methods Mol Biol 1187:169-79. 2014

Research Grants

  1. Scott A Holley; Fiscal Year: 2014

Scientific Experts

  • Francois Giudicelli
  • Kenro Kusumi
  • S Zeiser
  • Zoran Gucev
  • Sally L Dunwoodie
  • R Kageyama
  • Y Saga
  • Hiromi Shimojo
  • Leslie A Lyons
  • Taeko Kobayashi
  • Suma Choorapoikayil
  • Aitor Gonzalez
  • M Katoh
  • Yasumasa Bessho
  • Shubha R Phadke
  • Pedro Cabrales
  • Hao Zhu
  • Duncan B Sparrow
  • Yukiko Harima
  • Scott A Holley
  • Michael Stauber
  • Hendrik B Tiedemann
  • Yasuhide Nitanda
  • Takaaki Matsui
  • Kenji Kohno
  • Yoshiki Takashima
  • David Ish-Horowicz
  • Shinichi Hayashi
  • Xiao Xu
  • Sunita Warrier
  • Maria Teresa Bejar
  • Aideen M McInerney-Leo
  • Manjunath Netravathi
  • Paul J Leo
  • Li Jiang
  • Tatsuro Matta
  • Matthew A Brown
  • Emma L Duncan
  • Takeshi Fujimuro
  • Yasukazu Nakahata
  • Yuan Chieh Ku
  • Mahesh Mohan
  • Nathaniel P Hoyle
  • Lara Hooker
  • Xu Sheng Qiu
  • Toshiyuki Ohtsuka
  • Yuichi Sakumura
  • Peter D Turnpenny
  • K Köchert
  • Martin Hrabe de Angelis
  • Elida Schneltzer
  • Johannes Beckers
  • Gerhard K H Przemeck
  • Miguel Maroto
  • Zoltan Ferjentsik
  • William Sewell
  • J Kim Dale
  • Juliane Feller
  • Akiko Ishii
  • Kristin K Biris
  • Yasutaka Niwa
  • Yuriko Katoh
  • Wataru Satoh
  • Achim Gossler
  • Karin Schuster-Gossler
  • Yoshito Masamizu
  • Mitsuji Maruhashi
  • Jun Chen
  • Hiromi Hirata
  • Aki Ishikawa
  • Lin Miao
  • Katrin Serth
  • Hao Meng
  • Xin Sun
  • Xue Song Hu
  • Samer Nuwayhid
  • Lina Badimon
  • Irene E Zohn
  • Yue Chen Liu
  • Julia A Sabatino
  • Esther Pena
  • Shu Jin Luo
  • Raquel Ferrer-Lorente
  • Kelsey F Sugrue
  • He Yu
  • Yan Zhuang
  • Jessica E Harris
  • Victoria C O'Reilly
  • Mhairi S Marshall
  • Parthasarathy Satishchandra

Detail Information

Publications73

  1. ncbi Instability of Hes7 protein is crucial for the somite segmentation clock
    Hiromi Hirata
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Genet 36:750-4. 2004
    ..Expression of the basic helix-loop-helix factor Hes7, an effector of Notch signaling, follows a 2-hour oscillatory cycle controlled by negative feedback; this is ..
  2. ncbi Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis
    Xu Sheng Qiu
    Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
    Stud Health Technol Inform 176:52-5. 2012
    MESP2, HES7 and DUSP6 genes have been proved to be involved in the etiopathogenesis of congenital scoliosis (CS) in animal embryo studies, however, whether this association was detected in human CS patients also remains unknown...
  3. ncbi Oscillations, clocks and segmentation
    Yasumasa Bessho
    Institute for Virus Research Kyoto University Shogoin Kawahara, Sakyo ku Kyoto 606 8507, Japan
    Curr Opin Genet Dev 13:379-84. 2003
    Notch signalling molecules, such as the basic helix-loop-helix factors Hes1 and Hes7, periodically change their expression in the presomitic mesoderm, and each cycle of gene expression is associated with somite formation (every two hours ..
  4. ncbi Mesp-family genes are required for segmental patterning and segmental border formation
    Yumiko Saga
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Adv Exp Med Biol 638:113-23. 2008
    ..In the posterior PSM, a basic-HLH protein Hes7 plays a central role to generate traveling wave of gene expression by negatively regulating the transcription of ..
  5. ncbi Ultradian oscillators in somite segmentation and other biological events
    R Kageyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Cold Spring Harb Symp Quant Biol 72:451-7. 2007
    ..During this process, the basic helix-loop-helix gene Hes7 is cyclically expressed, and each cycle leads to generation of a bilateral pair of somites...
  6. pmc Supt20 is required for development of the axial skeleton
    Sunita Warrier
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Dev Biol . 2016
    ..the prospective rostral somite was reduced accompanied by expansion of caudal somite markers such as EphrinB2 and Hes7. Supt20 interacts with the Gcn5-containing SAGA histone acetylation complex...
  7. doi 3'-UTR-dependent regulation of mRNA turnover is critical for differential distribution patterns of cyclic gene mRNAs
    Yasuhide Nitanda
    Laboratory of Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Japan
    FEBS J 281:146-56. 2014
    ..periodic event in the development of vertebrates, is instructed by cyclic expression of several genes, including Hes7 and Lunatic fringe (Lfng). Transcriptional regulation accounts for the cyclic expression...
  8. pmc The transcriptome of utricle hair cell regeneration in the avian inner ear
    Yuan Chieh Ku
    Department of Genetics and Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110
    J Neurosci 34:3523-35. 2014
    ..For example, we show that HES7 is specifically expressed during utricle hair cell regeneration and closely parallels the expression of HES5...
  9. doi The roles and mechanism of ultradian oscillatory expression of the mouse Hes genes
    Yukiko Harima
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan Japan Science and Technology Agency, Core Research for Evolutional Science and Technology CREST, 4 1 8 Honcho, Kawaguchi, Saitama 332 0012, Japan
    Semin Cell Dev Biol 34:85-90. 2014
    ..biological clock called the segmentation clock, which involves cyclic expression of the basic helix-loop-helix gene Hes7. Hes7 oscillation is regulated by negative feedback with a delayed timing...
  10. doi Visualization of Notch signaling oscillation in cells and tissues
    Hiromi Shimojo
    Institute for Virus Research and World Premier International Research Initiative Institute for Integrated Cell Material Sciences WPI iCeMS, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto, 606 8507, Japan
    Methods Mol Biol 1187:169-79. 2014
    The Notch signaling effectors Hes1 and Hes7 exhibit oscillatory expression with a period of about 2-3 h during embryogenesis...
  11. doi Expression dynamics and functions of Hes factors in development and diseases
    Taeko Kobayashi
    Institute for Virus Research, Kyoto University, Kyoto, Japan Japan Science and Technology Agency, Core Research for Evolutional Science and Technology CREST, Saitama, Japan Electronic address
    Curr Top Dev Biol 110:263-83. 2014
    ..Hes1, Hes5, and Hes7 are known as downstream effectors of canonical Notch signaling, which regulates cell differentiation via cell-cell ..
  12. pmc Hes7 3'UTR is required for somite segmentation function
    Takeshi Fujimuro
    Laboratory of Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Sci Rep 4:6462. 2014
    ..We attempted to elongate the oscillation period by increasing the time to transcribe Hes7 in this research. We generated knock-in mice, in which a large intron was inserted into Hes7 3'UTR...
  13. pmc Higher frequency of intron loss from the promoter proximally paused genes of Drosophila melanogaster
    Li Jiang
    a MOE Key Laboratory for Biodiversity Science and Ecological Engineering and Beijing Key Laboratory of Gene Resource and Molecular Development College of Life Sciences Beijing Normal University Beijing, PR China
    Fly (Austin) 8:120-5. 2014
    ..studies on the rates of transcription and splicing and to the time saved by deletion of the introns from mouse gene Hes7, it is here suggested that transcription delay is comparable to splicing delay only when the intron is 28...
  14. pmc Whole exome sequencing in an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 variation
    Manjunath Netravathi
    Department of Neurology, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, 560029, India
    BMC Med Genet 16:5. 2015
    ..It is caused by compound heterozygous mutations in the CTC1 gene...
  15. doi Oscillatory control of Delta-like1 in somitogenesis and neurogenesis: A unified model for different oscillatory dynamics
    Hiromi Shimojo
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan World Premier International Research Initiative Institute for Integrated Cell Material Sciences WPI iCeMS, Kyoto University, Kyoto 606 8501, Japan Electronic address
    Semin Cell Dev Biol 49:76-82. 2016
    ..Under this condition, oscillation of the Notch effector Hes7 is also dampened, leading to severe fusion of somites and their derivatives, such as vertebrae and ribs...
  16. pmc Whole Genome Sequencing Identifies a Missense Mutation in HES7 Associated with Short Tails in Asian Domestic Cats
    Xiao Xu
    Peking Tsinghua Center for Life Sciences, Laboratory of Genomic Diversity and Evolution, School of Life Sciences, Peking University, Beijing 100871, China
    Sci Rep 6:31583. 2016
    ..6 Mb region of Chr E1, within which the substitution c. 5T > C in the somite segmentation-related gene HES7 was identified as the causal mutation resulting in a missense change (p.V2A)...
  17. doi Inhibition of Notch rescues the angiogenic potential impaired by cardiovascular risk factors in epicardial adipose stem cells
    Maria Teresa Bejar
    Cardiovascular Research Center, Consejo Superior de Investigaciones Científicas Institut Català de Ciències Cardiovasculars, Institut d Investigació Biomèdica Sant Pau, Barcelona, Spain
    FASEB J 30:2849-59. 2016
    ..Epicardial ASCs from CVRF rats showed up-regulation of the downstream Notch signaling genes Hes7, Hey1, and Heyl compared with control animals...
  18. doi Compound heterozygous mutations in RIPPLY2 associated with vertebral segmentation defects
    Aideen M McInerney-Leo
    The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba QLD 4102, Australia
    Hum Mol Genet 24:1234-42. 2015
    ..genes involved in the Notch pathway are associated with SDV, with both autosomal recessive (MESP2, DLL3, LFNG, HES7) and autosomal dominant (TBX6) inheritance...
  19. pmc Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock
    Aitor Gonzalez
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    PLoS ONE 8:e53323. 2013
    ..A crucial component of the segmentation clock is the gene Hes7, which is regulated by the Notch and Fgf/Mapk pathways, but its relation to other pathways is unknown...
  20. pmc From dynamic expression patterns to boundary formation in the presomitic mesoderm
    Hendrik B Tiedemann
    Institute of Experimental Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Comput Biol 8:e1002586. 2012
    ..Assuming Hes7 as core of the somitogenesis clock and LFNG as modulator, we postulate a negative feedback of HES7 on Dll1 leading ..
  21. doi Microarray-based identification of Pitx3 targets during Xenopus embryogenesis
    Lara Hooker
    Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada
    Dev Dyn 241:1487-505. 2012
    ..Microarray analysis was, therefore, used to assess global transcriptional changes downstream of Pitx3...
  22. doi Brothers with hypospadias, vertebral segmentation defects, and intellectual disability: new syndrome?
    Shubha R Phadke
    Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Am J Med Genet A 158:3065-70. 2012
    ..variants, microarray-CGH analysis, and sequencing of four Notch signaling pathway genes (DLL3, MESP2, LFNG, and HES7), were all normal...
  23. doi Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene
    Yukiko Harima
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Cell Rep 3:1-7. 2013
    Periodic somite segmentation is controlled by the cyclic gene Hes7, whose oscillatory expression depends upon negative feedback with a delayed timing...
  24. doi Autosomal dominant spondylocostal dysostosis is caused by mutation in TBX6
    Duncan B Sparrow
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia
    Hum Mol Genet 22:1625-31. 2013
    ..recessive SCD cases has been solved with the identification of four causative genes (DLL3, MESP2, LFNG and HES7)...
  25. pmc Focused examination of the intestinal epithelium reveals transcriptional signatures consistent with disturbances in enterocyte maturation and differentiation during the course of SIV infection
    Mahesh Mohan
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 8:e60122. 2013
    ..In contrast, expression of NOTCH3, notch target genes (HES4, HES7) and EZH2 (histone methyltransferase) were significantly increased at 90DPI...
  26. doi Oscillatory gene expression and somitogenesis
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Wiley Interdiscip Rev Dev Biol 1:629-41. 2012
    ..Expression of her1 and her7 in zebrafish and Hes7 in mice oscillates by negative feedback, and mathematical models have been used to generate and test hypotheses to ..
  27. doi Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus
    Duncan B Sparrow
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Am J Med Genet A 161:2244-9. 2013
    ..We found that both individuals were homozygous for the same mutation in HES7, and that this mutation caused a significant reduction of HES7 protein function; HES7 mutation causes SCD4...
  28. ncbi Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 17:681-5. 2006
    ..histone acetyltransferase (HAT), then induces transcriptional activation of Notch target genes, such as HES1, HES5, HES7, HEY1, HEY2 and HEYL...
  29. pmc Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes
    Nathaniel P Hoyle
    Cancer Research UK Developmental Genetics Laboratory, London Research Institute, London WC2A 3LY, United Kingdom
    Proc Natl Acad Sci U S A 110:E4316-24. 2013
    ..Here, we measure expression delays for three transcripts [Lunatic fringe, Hes7/her1, and Notch-regulated-ankyrin-repeat-protein (Nrarp)], that cycle during segmentation in the zebrafish, chick, ..
  30. ncbi Comparative genomics on HHIP family orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 17:391-5. 2006
    ..Expression of HES/HEY family members, including HES1, HES2, HES3, HES4, HES5, HES6, HES7, HEY1, HEY2 and HEYL, in coronary artery endothelial cells was not detected in silico...
  31. doi Oscillatory links of Fgf signaling and Hes7 in the segmentation clock
    Yukiko Harima
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Curr Opin Genet Dev 23:484-90. 2013
    Somitogenesis is controlled by the segmentation clock, where the oscillatory expression of cyclic genes such as Hes7 leads to the periodic expression of Mesp2, a master gene for somite formation...
  32. pmc Analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock module
    Suma Choorapoikayil
    Institute for Genetics, University to Cologne, Koeln, Germany
    PLoS ONE 7:e39073. 2012
    ..Due to genome duplication events, the zebrafish genome, possesses two gene copies of the mouse Hes7 homologue: her1 and her7...
  33. doi Modifying transcript lengths of cycling mouse segmentation genes
    Michael Stauber
    Developmental Genetics Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A3LY, United Kingdom
    Mech Dev 129:61-72. 2012
    ..Mutants in several oscillating genes including the Notch pathway gene Lunatic fringe (Lfng) and the Notch target Hes7, result in defective somitogenesis and disorganised axial skeletons...
  34. pmc Intronic delay is essential for oscillatory expression in the segmentation clock
    Yoshiki Takashima
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 108:3300-5. 2011
    ..The basic helix-loop-helix repressor gene Hes7 is cyclically expressed in the presomitic mesoderm (PSM) and regulates the somite segmentation...
  35. doi High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas
    K Köchert
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Oncogene 30:1831-40. 2011
    ..of MAML or by small hairpin RNAs targeting MAML2 in cHL cells resulted in downregulation of the NOTCH target genes HES7 and HEY1, which we identified as overexpressed in cHL cells, and in reduced proliferation...
  36. doi Ultradian oscillations in Notch signaling regulate dynamic biological events
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto, Japan
    Curr Top Dev Biol 92:311-31. 2010
    ..by a biological clock called the segmentation clock, which involves cyclic expression of the Notch effector gene Hes7. Loss of Hes7 expression and sustained expression of Hes7 result in identical and severe somite defects, suggesting ..
  37. doi Autosomal dominant spondylocostal dysostosis in three generations of a Macedonian family: Negative mutation analysis of DLL3, MESP2, HES7, and LFNG
    Zoran S Gucev
    Medical Faculty Skopje, Divizija BB, Skopje, Macedonia
    Am J Med Genet A 152:1378-82. 2010
    ..symmetrical thoracic cage, and result from mutations in Notch signaling pathway genes-DLL3, MESP2, LFNG, and HES7. Autosomal dominant (AD) SCD has been reported less often, is very variable, and molecular genetic mechanisms ..
  38. pmc Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites
    Zoltan Ferjentsik
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    PLoS Genet 5:e1000662. 2009
    ..analysing embryos carrying a mutation in different components of the Notch pathway, such as Lunatic fringe (Lfng), Hes7, Rbpj, and presenilin1/presenilin2 (Psen1/Psen2), and by pharmacological blocking of the Notch pathway...
  39. ncbi Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling
    Aki Ishikawa
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Mech Dev 121:1443-53. 2004
    ..whereas nkd1 oscillations have a similar phase to lunatic fringe (L-fng) transcription and they are arrested in Hes7 (a negative regulator of Notch signaling) deficient embryos...
  40. ncbi Oscillator mechanism of Notch pathway in the segmentation clock
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, and Japan Science and Technology Agency, CREST, Kyoto, Japan
    Dev Dyn 236:1403-9. 2007
    ..The basic helix-loop-helix factor Hes7, a Notch effector, is cyclically expressed by negative feedback and regulates cyclic expression of Lunatic fringe (..
  41. ncbi Notch signaling in gastrointestinal tract (review)
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 30:247-51. 2007
    ..the maintenance of stem or progenitor (transit-amplifying) cells through transcriptional activation of HES1, HES5, HES7, HEY1, HEY2 and HEYL genes, and also to the NF-kappaB-NICD complex for the augmentation of NF-kappaB signaling...
  42. ncbi Transient block of receptor may be a mechanism controlling unidirectional propagation of signaling
    Hao Zhu
    Bioinformatics Institute of Singapore, Biopolis Street, 138671, Singapore
    IEEE Trans Nanobioscience 5:193-203. 2006
    ..block of Notch by Notch induced Lfng and the delayed removal of the block by another Notch induced protein Hes7 may explain the observed unidirectional propagation of Notch signaling in these cells...
  43. pmc Number of active transcription factor binding sites is essential for the Hes7 oscillator
    Stefan Zeiser
    Institute of Biomathematics and Biometry, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Theor Biol Med Model 3:11. 2006
    ..segmentation of vertebrates is regulated by a segmentation clock, which is induced by the cycling genes Hes1 and Hes7. Their products form dimers that bind to the regulatory regions and thereby repress the transcription of their own ..
  44. ncbi Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis
    Wataru Satoh
    Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Chuou ku, Kobe 650 0047, Japan
    Development 133:989-99. 2006
    ..somite segmentation is associated with altered oscillations of Notch signaling, as evidenced by abnormal Lfng and Hes7 expression during somitogenesis in the thoracic region...
  45. ncbi Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis
    Jun Chen
    Laboratory of Developmental Genetics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Genesis 43:196-204. 2005
    ..We also show that Hes7, another cyclically expressed protein, can bind to the N-boxes on both Lfng and its own promoters and repress their ..
  46. ncbi Involvement of SIP1 in positioning of somite boundaries in the mouse embryo
    Mitsuji Maruhashi
    Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
    Dev Dyn 234:332-8. 2005
    ..This is accompanied by the rostral extension of oscillatory gene expression such as L-fng, Hes7, and Dll1, and the rostrally shifted termination of Raldh2 expression that continues from the anterior embryonic ..
  47. ncbi Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92093 0412, USA
    Shock 23:549-55. 2005
    ..3% or 0.6% (w/v) alginate (groups HES7 and HES10, respectively) leading to solutions with a uniform colloidal oncotic pressure (84-87 mmHg) and ..
  48. ncbi Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of Notch activity
    Yumiko Saga
    Division of Mammalian Development, National Institute of Genetics, and Department of Genetics, SOKENDAI, Mishima, Japan
    Dev Dyn 236:1450-5. 2007
    ..In the posterior PSM, the basic helix-loop-helix (bHLH) protein Hes7 plays a central role in generating a traveling wave of gene expression by negatively regulating the transcription ..
  49. ncbi Identification and characterization of human HESL, rat Hesl and rainbow trout hesl genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:747-51. 2004
    ..with ORANGE domain were classified into the following three groups: (group I) HES1, HES2, HES4 and HES6 orthologs; (group II) HESL, HES5, HES7, HEY1, HEY2 and HEYL orthologs; (group III) HES3, DEC1/BHLHB2 and DEC2/BHLHB3 orthologs.
  50. ncbi The vertebrate segmentation clock
    Francois Giudicelli
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Curr Opin Genet Dev 14:407-14. 2004
    ..of these is based on direct autoinhibition of certain members of the hairy/E(spl) family of Notch target genes--Hes7 in the mouse, and her1 and her7 in the zebrafish...
  51. ncbi Identification and characterization of human HES2, HES3, and HES5 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 25:529-34. 2004
    ..Human HES1, HES4, HES6, and HES7 genes have been reported by other groups...
  52. ncbi Dll3 pudgy mutation differentially disrupts dynamic expression of somite genes
    Kenro Kusumi
    Divisions of Human Genetics and Orthopaedic Surgery, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Genesis 39:115-21. 2004
    ..In the mouse, notch pathway genes such as Lfng, Hes1, Hes7, and Hey2 display dynamic patterns of expression in paraxial mesoderm, cycling in synchrony with somite formation (..
  53. pmc Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock
    Yasumasa Bessho
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Dev 17:1451-6. 2003
    b>Hes7, a bHLH gene essential for somitogenesis, displays cyclic expression of mRNA in the presomitic mesoderm (PSM). Here, we show that Hes7 protein is also expressed in a dynamic manner, which depends on proteasome-mediated degradation...
  54. pmc Transcriptional oscillation of lunatic fringe is essential for somitogenesis
    Katrin Serth
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Genes Dev 17:912-25. 2003
    ..Similarly, dynamic expression of Hes7 was not abolished but abnormal expression patterns were obtained...
  55. pmc Dynamic expression and essential functions of Hes7 in somite segmentation
    Y Bessho
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Dev 15:2642-7. 2001
    The basic helix-loop-helix (bHLH) gene Hes7, a putative Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM)...
  56. pmc Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation
    Juliane Feller
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Hanover, Germany
    Genes Dev 22:2166-71. 2008
    ..Embryos expressing NICD formed up to 18 somites. Expression in the PSM of Hes7, Lfng, and Spry2 was no longer cyclic, whereas Axin2 was expressed dynamically...
  57. pmc Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis
    Michael Stauber
    Developmental Genetics Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    PLoS ONE 4:e7996. 2009
    ..segments normally in the complete absence of Lfng and shows a reduced requirement for another oscillating gene, Hes7, indicating that the architecture of the clock alters as segmentation progresses...
  58. ncbi Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm
    Y Bessho
    Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Genes Cells 6:175-85. 2001
    ....
  59. doi The role of Notch in patterning the human vertebral column
    Sally L Dunwoodie
    Developmental Biology Division, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW 2010 Sydney, Australia
    Curr Opin Genet Dev 19:329-37. 2009
    ..More specifically it describes that mutations in genes encoding Notch pathway components (DLL3, MESP2, LFNG and HES7) cause severe congenital vertebral defects in humans...
  60. doi Rhythmic gene expression in somite formation and neural development
    Ryoichiro Kageyama
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Mol Cells 27:497-502. 2009
    ..biological clock called the segmentation clock, which involves cyclic expression of the basic helix-loop-helix gene Hes7. Hes7 expression oscillates by negative feedback and is cooperatively regulated by Fgf and Notch signaling...
  61. pmc Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM
    Shinichi Hayashi
    Laboratory of Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan
    PLoS ONE 4:e5603. 2009
    ....
  62. pmc Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis
    William Sewell
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Dev Biol 329:400-9. 2009
    ..Null mutations of Dll3 disrupt cycling expression of Notch targets Hes1, Hes5, and Lfng, but not of Hes7. Compared with Dll1 or Notch1, the effects of Dll3 mutations are less severe for gene expression in the presomitic ..
  63. doi Hopf bifurcation in the presomitic mesoderm during the mouse segmentation
    Aitor Gonzalez
    Institute for Virus Research, Kyoto University, Japan
    J Theor Biol 259:176-89. 2009
    ..The pace of somite formation is controlled by gene products such as hairy and enhancer of split 7 (Hes7) whose expression oscillates in the PSM...
  64. doi Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis
    Duncan B Sparrow
    Developmental Biology Division, Victor ChangCardiac Research Institute, Darlinghurst, Sydney, NSW, Australia
    Hum Mol Genet 17:3761-6. 2008
    ..used autozygosity mapping to identify a mutation in a fourth Notch pathway gene, Hairy-and-Enhancer-of-Split-7 (HES7), in an autosomal recessive SCD family...
  65. pmc Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis
    Duncan B Sparrow
    Developmental Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia
    Eur J Hum Genet 18:674-9. 2010
    ..have been identified: DLL3 (SCDO1: MIM 277300), MESP2 (SCDO2: MIM 608681), LFNG (SCDO3: MIM609813) and HES7 (SCDO4)...
  66. doi Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7
    Akiko Ishii
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 372:142-6. 2008
    The basic helix-loop-helix (bHLH) gene Hes7 is expressed in an oscillatory manner and regulates the periodic somite formation...
  67. ncbi Oscillations of Hes7 caused by negative autoregulation and ubiquitination
    S Zeiser
    GSF, National Research Centre for Environment and Health, Institute of Biomathematics and Biometry, Ingolstadter Landstrasse 1, 85764 Oberschleissheim, Germany
    Comput Biol Chem 32:47-51. 2008
    Loss of Hes7 function leads to irregular somite formation demonstrating that Hes7 is a crucial component of the segmentation clock during somitogenesis...
  68. ncbi Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis
    Kristin K Biris
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, NCI Frederick, NIH, Frederick, Maryland 21702, USA
    Dev Dyn 236:3167-72. 2007
    ..Continued expression of Ripply2 in embryos lacking Hes7, a molecular oscillator in the Notch clock, indicates that Hes7 is not a major regulator of Ripply2...
  69. ncbi The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock
    Yasutaka Niwa
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Dev Cell 13:298-304. 2007
    Periodic formation of somites is controlled by the segmentation clock, where the oscillator Hes7 regulates cyclic expression of the Notch modulator Lunatic fringe...
  70. ncbi Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 31:461-6. 2007
    ..bHLH transcription factors with Orange domain were grouped into HES subfamily (HES1, HES2, HES3, HES4, HES5, HES6, HES7) and HEY subfamily (HEY1, HEY2, HEYL, HESL/HELT, DEC1/BHLHB2, DEC2/BHLHB3)...
  71. ncbi Cell-based simulation of dynamic expression patterns in the presomitic mesoderm
    Hendrik B Tiedemann
    Institute of Experimental Genetics, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    J Theor Biol 248:120-9. 2007
    ..The clock is realised through cycling expression of genes such as Hes1 and Hes7, whose gene products repress the transcription of their encoding genes in a negative feedback loop...

Research Grants1

  1. Scott A Holley; Fiscal Year: 2014
    ..In humans, mutation of HES7 results in spondylocostal dysostosis, a congenital disorder characterized by fusion or malformation of the ..