hepatocyte growth factor

Summary

Gene Symbol: hepatocyte growth factor
Description: hepatocyte growth factor
Alias: DFNB39, F-TCF, HGFB, HPTA, hepatocyte growth factor, fibroblast-derived tumor cytotoxic factor, hepatocyte growth factor (hepapoietin A; scatter factor), hepatopoietin-A, lung fibroblast-derived mitogen
Species: human

Top Publications

  1. pmc HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver
    Orit Kollet
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Clin Invest 112:160-9. 2003
  2. ncbi Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma
    Patrick W B Derksen
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Blood 99:1405-10. 2002
  3. ncbi Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2
    David C West
    School of Biological Sciences, Biosciences Building, University of Liverpool, Liverpool, L69 7ZB, United Kingdom
    J Biol Chem 280:13457-64. 2005
  4. doi Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction
    Ye Ji Lee
    Dept of Physiology, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 911 1 Mok 6 dong, Yangcheon Gu, Seoul 158 056, Korea
    Eur Respir J 40:424-35. 2012
  5. ncbi HGF induces fibronectin matrix synthesis in melanoma cells through MAP kinase-dependent signaling pathway and induction of Egr-1
    Cedric Gaggioli
    INSERM Unité 597, Biologie et Pathologies des cellules mélanocytaires, équipe labellisée la Ligue 2001, IFR 50, 06107 Nice Cedex 2, France
    Oncogene 24:1423-33. 2005
  6. doi Stabilization of hepatocyte growth factor mRNA by hypoxia-inducible factor 1
    Sheng Hua Chu
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mol Biol Rep 36:1967-75. 2009
  7. ncbi Hepatocyte growth factor enhances ovarian cancer cell invasion through downregulation of thrombospondin-1
    Wei Wei
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji nan 250012, Shandong, China
    Cancer Biol Ther 9:79-87. 2010
  8. doi Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart
    Georgina M Ellison
    The Stem Cell and Regenerative Biology Unit BioStem, RISES, Liverpool John Moores University, Liverpool, UK
    J Am Coll Cardiol 58:977-86. 2011
  9. ncbi Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development
    G Li
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, PA 19104, USA
    Oncogene 20:8125-35. 2001
  10. doi Hepatocyte growth factor induced up-regulations of VEGF through Egr-1 in hepatocellular carcinoma cells
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu 705 717, Republic of Korea
    Clin Exp Metastasis 26:685-92. 2009

Research Grants

  1. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
  2. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
  3. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
  4. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
  5. HGF/HGFR Axis and Fatty Liver Disease
    Reza Zarnegar; Fiscal Year: 2013
  6. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
  7. HGF Signaling in Kidney Repair
    Lloyd G Cantley; Fiscal Year: 2012
  8. Safety and efficacy of optimized AAV3 vectors in murine and NHP livers
    Arun Srivastava; Fiscal Year: 2013
  9. Reza Zarnegar; Fiscal Year: 2015
  10. Secreted Wnt Inhibitors in the Biology of Osteosarcoma
    Bang H Hoang; Fiscal Year: 2010

Detail Information

Publications260 found, 100 shown here

  1. pmc HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver
    Orit Kollet
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Clin Invest 112:160-9. 2003
    ..Our results suggest the potential of hematopoietic CD34+/CXCR4+cells to respond to stress signals from nonhematopoietic injured organs as an important mechanism for tissue targeting and repair...
  2. ncbi Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma
    Patrick W B Derksen
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Blood 99:1405-10. 2002
    ..For this purpose, the interaction was studied between syndecan-1 and hepatocyte growth factor (HGF), a putative paracrine and autocrine regulator of MM growth...
  3. ncbi Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2
    David C West
    School of Biological Sciences, Biosciences Building, University of Liverpool, Liverpool, L69 7ZB, United Kingdom
    J Biol Chem 280:13457-64. 2005
    ..The results show that fibroblast growth factor (FGF) 1, 2, 4, and 7, FGF receptor 1, hepatocyte growth factor/scatter factor (HGF/SF), FGF-binding protein, normal protease sensitive form of prion protein, ..
  4. doi Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction
    Ye Ji Lee
    Dept of Physiology, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 911 1 Mok 6 dong, Yangcheon Gu, Seoul 158 056, Korea
    Eur Respir J 40:424-35. 2012
    Apoptotic cell clearance by macrophages and neighbouring tissue cells induces hepatocyte growth factor (HGF) secretion. HGF plays a key role in alveolar epithelial regeneration and reconstruction after lung injury...
  5. ncbi HGF induces fibronectin matrix synthesis in melanoma cells through MAP kinase-dependent signaling pathway and induction of Egr-1
    Cedric Gaggioli
    INSERM Unité 597, Biologie et Pathologies des cellules mélanocytaires, équipe labellisée la Ligue 2001, IFR 50, 06107 Nice Cedex 2, France
    Oncogene 24:1423-33. 2005
    ..We report that hepatocyte growth factor/scatter factor (HGF) induces fibronectin expression and its extracellular assembly on the surface of ..
  6. doi Stabilization of hepatocyte growth factor mRNA by hypoxia-inducible factor 1
    Sheng Hua Chu
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mol Biol Rep 36:1967-75. 2009
    Hypoxia regulates expression of hepatocyte growth factor (HGF) by increasing its transcription and by stabilizing its mRNA...
  7. ncbi Hepatocyte growth factor enhances ovarian cancer cell invasion through downregulation of thrombospondin-1
    Wei Wei
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji nan 250012, Shandong, China
    Cancer Biol Ther 9:79-87. 2010
    b>Hepatocyte growth factor (HGF) plays an important role in stimulating tumor invasion and metastasis of tumor cells. However, the exact mechanisms of HGF regulation of cell invasion are largely unknown...
  8. doi Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart
    Georgina M Ellison
    The Stem Cell and Regenerative Biology Unit BioStem, RISES, Liverpool John Moores University, Liverpool, UK
    J Am Coll Cardiol 58:977-86. 2011
    The purpose of this study was to test the ability of insulin-like growth factor (IGF)-1/hepatocyte growth factor (HGF) to activate resident endogenous porcine cardiac stem/progenitor cells (epCSCs) and to promote myocardial repair through ..
  9. ncbi Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development
    G Li
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, PA 19104, USA
    Oncogene 20:8125-35. 2001
    ..This study investigated the regulation of cell adhesion by hepatocyte growth factor (HGF) in melanoma...
  10. doi Hepatocyte growth factor induced up-regulations of VEGF through Egr-1 in hepatocellular carcinoma cells
    Kyung Hee Lee
    Department of Hemato Oncology, College of Medicine, Yeungnam University, Daegu 705 717, Republic of Korea
    Clin Exp Metastasis 26:685-92. 2009
    The potential role of hepatocyte growth factor (HGF) in the regulation of angiogenesis factors in hepatoma cells is not widely appreciated...
  11. pmc Hepatocyte growth factor in lung repair and pulmonary fibrosis
    Ronald Allan M Panganiban
    Department of Pharmacology, Uniformed Services University of Health Sciences, Bethesda, MD 20852, USA
    Acta Pharmacol Sin 32:12-20. 2011
    ..b>Hepatocyte growth factor (HGF) is a pleiotropic factor, which induces cellular motility, survival, proliferation, and ..
  12. doi Hepatocyte growth factor suppresses transforming growth factor-beta-1 and type III collagen in human primary renal fibroblasts
    Shan Mou
    Renal Division, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Kaohsiung J Med Sci 25:577-87. 2009
    ..In contrast, hepatocyte growth factor (HGF) has shown therapeutic effects on injured renal tubules in animal models...
  13. doi Alteration of HGF and TSP-1 expression in ovarian carcinoma associated with clinical features
    Wei Wei
    Departments of Obstetrics and Gynecology Basic Medicine, Qilu Hospital of Shandong University Department of Obstetrics and Gynecology, Provincial Hospital affiliated to Shandong University, Shandong, China
    J Obstet Gynaecol Res 38:57-64. 2012
    The aim of this study was to investigate the expression levels of hepatocyte growth factor (HGF) and thrombospondin-1 (TSP-1) with the clinical pathological factors in ovarian cancer, and the correlation between HGF and TSP-1 expression ..
  14. ncbi SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism
    Takao Toyoda
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Biochem Biophys Res Commun 360:715-20. 2007
    ..Transforming growth factor-beta (TGFbeta) isoforms play an important role in neuronal survival, and the hepatocyte growth factor (HGF) has been shown to exhibit neurotrophic activity...
  15. doi AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor
    Stephanie Schnickmann
    Institute of Pathology, University Hospital of Heidelberg, Heidelberg, Germany
    J Invest Dermatol 129:1140-8. 2009
    ..Mesenchymal cell-derived hepatocyte growth factor (HGF) is a central regulator of this process...
  16. pmc Hepatocyte growth factor and keratinocyte growth factor enhance IL-1-induced IL-8 secretion through different mechanisms in Caco-2 epithelial cells
    Benjamin L Unger
    Department of Biological Sciences, Binghamton University SUNY, Binghamton, NY 13902 6000, USA
    In Vitro Cell Dev Biol Anim 47:173-81. 2011
    ..Previously, we have shown that hepatocyte growth factor (HGF) could significantly enhance IL-1-stimulated IL-8 secretion by the Caco-2 colonic epithelial cell ..
  17. doi Differential gene expression of MMP-1, TIMP-1 and HGF in clinically involved and uninvolved skin in South Africans with SSc
    Jacqueline Frost
    Division of Rheumatology, Faculty of Health Sciences, Chris Hani Baragwanath Academic Hospital, P O Bertsham 2013, South Africa
    Rheumatology (Oxford) 51:1049-52. 2012
    To investigate the differential expression of MMP-1, tissue inhibitor of metalloproteinase-1 (TIMP-1) and hepatocyte growth factor (HGF) in clinically involved (affected) and uninvolved (unaffected) skin in patients with SSc.
  18. ncbi Hepatocyte growth factor regulates E box-dependent plasminogen activator inhibitor type 1 gene expression in HepG2 liver cells
    Shogo Imagawa
    The Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kitaku, Sapporo, Japan 060 8638
    Arterioscler Thromb Vasc Biol 26:2407-13. 2006
    We sought to determine the etiologic mechanism of pleiotropic growth factor, hepatocyte growth factor (HGF), as a regulator of hepatic synthesis of plasminogen activator inhibitor (PAI)-1, the physiological inhibitor of fibrinolysis and a ..
  19. pmc DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1
    Alice Ly
    Department of Molecular, Cellular, and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA
    Cell 133:1241-54. 2008
    ..These results show that DSCAM is a receptor that can mediate turning responses to netrin-1 and support a key role for netrin/DSCAM signaling in commissural axon guidance in vertebrates...
  20. pmc Evidence for the identity of human scatter factor and human hepatocyte growth factor
    K M Weidner
    Institut für Zellbiologie Tumorforschung, Medical School, Essen, Federal Republic of Germany
    Proc Natl Acad Sci U S A 88:7001-5. 1991
    ..b>Hepatocyte growth factor (HGF), a protein isolated from serum of patients with liver failure, is a potent mitogen for hepatocytes ..
  21. pmc Hepatocyte growth factor promotes lymphatic vessel formation and function
    Kentaro Kajiya
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    EMBO J 24:2885-95. 2005
    ..versus blood vascular endothelial cells (BVEC) revealed that LEC express significantly higher levels of hepatocyte growth factor receptor (HGF-R)...
  22. pmc HGF and MET mutations in primary and secondary lymphedema
    David N Finegold
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Lymphat Res Biol 6:65-8. 2008
    ..Recent observations suggested that hepatocyte growth factor/high affinity hepatocyte growth factor receptor (HGF/MET) were new candidate lymphedema genes.
  23. pmc HGF-induced PKCζ activation increases functional CXCR4 expression in human breast cancer cells
    Songyin Huang
    Department of Laboratory, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 7:e29124. 2012
    ..Interaction between hepatocyte growth factor (HGF) and the Met receptor tyrosine kinase mediates development and progression of cancers...
  24. ncbi Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair
    Lorraine B Ware
    Division of Pulmonary and Critical Care, Department of Medicine, University of California, Los Angeles 90024, USA
    Am J Physiol Lung Cell Mol Physiol 282:L924-40. 2002
    ..growth factors keratinocyte growth factor (KGF), fibroblast growth factor (FGF)-10, and hepatocyte growth factor (HGF) play important roles in lung development, lung inflammation, and repair...
  25. ncbi Activation of the hepatocyte growth factor (HGF)-Met system in papillary thyroid cancer: biological effects of HGF in thyroid cancer cells depend on Met expression levels
    Rossana Mineo
    Dipartimento di Medicina Sperimentale e Clinica, Policlinico Mater Domini, University of Catanzaro Magna Graecia, Via Tommaso Campanella 115, 88100 Catanzaro, Italy
    Endocrinology 145:4355-65. 2004
    Met, the receptor for hepatocyte growth factor (HGF), is overexpressed in approximately 90% papillary thyroid carcinomas...
  26. ncbi Co-elevated expression of hepatocyte growth factor and Interleukin-8 contributes to poor prognosis of patients with primary nasopharyngeal carcinoma
    Li Qiong Xie
    Department of Pathology, 1st Affiliated Hospital, Sun Yat Sen University, Guangzhou, P R China
    Oncol Rep 23:141-50. 2010
    b>Hepatocyte growth factor (HGF) related tumor angiogenesis and prognosis of patients with nasopharyngeal carcinoma (NPC) has not been identified...
  27. pmc The association of hepatocyte growth factor (HGF) gene with primary angle closure glaucoma in the Nepalese population
    Mona S Awadalla
    Department of Ophthalmology, Flinders University, Flinders Medical Centre Adelaide, South Australia
    Mol Vis 17:2248-54. 2011
    Genetic variation in the hepatocyte growth factor (HGF) gene has recently been associated with hyperopia, which is a known risk factor for primary angle closure glaucoma (PACG)...
  28. ncbi The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner
    Magda Kucia
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, 529 South Jackson Street, Louisville, KY 40202, USA
    Arch Immunol Ther Exp (Warsz) 54:121-35. 2006
    ..In this study we evaluated whether TCSCs respond to other motomorphogens, such as hepatocyte growth factor (HGF) and leukemia inhibitory factor (LIF).
  29. ncbi Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression
    Qinghua Zeng
    Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, School of Dentistry and Medicine, University of Michigan, 1011 N University Avenue, Ann Arbor, MI 48109 1078, USA
    J Biol Chem 277:50137-42. 2002
    ..Recently we found that hepatocyte growth factor (HGF) inhibited anoikis of human head and neck squamous cell carcinoma (HNSCC) cells by activating the ..
  30. ncbi Expression of hepatocyte growth factor and c-Met in the anterior horn cells of the spinal cord in the patients with amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS and familial ALS with superoxide dismutase 1 gene mutation
    Shinsuke Kato
    Department of Neuropathology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Nishi cho 36 1, 683 8504, Yonago, Japan
    Acta Neuropathol 106:112-20. 2003
    ..with superoxide dismutase 1 (SOD1) mutations, we investigated the immunohistochemical expression of hepatocyte growth factor (HGF), a novel neurotrophic factor, and its receptor, c-Met...
  31. ncbi Hepatocyte growth factor-activated NF-kappaB regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines
    L Tacchini
    Institute of General Pathology, University of Milan, Via Luigi Mangiagalli 31, 20133 Milan, Italy
    Carcinogenesis 25:2089-100. 2004
    b>Hepatocyte growth factor (HGF)-stimulated Met signaling influences tumor survival, growth and progression, all processes involving the transcription factor NF-kappaB...
  32. ncbi Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: evidence for the involvement of plasma IgG, complement C3 and beta2 integrin
    Y Takeda
    Japan Immunoresearch Laboratories, 351 1, Nishiyokote Cho, 370 0021, Takasaki, Gunma, Japan
    Inflamm Res 53:277-83. 2004
    ..This study was undertaken to obtain insights into mechanisms of anti-inflammatory actions of adsorptive GM apheresis with CA beads...
  33. pmc Reinke's edema: investigations on the role of MIB-1 and hepatocyte growth factor
    M Artico
    Department of Otorhinolaringology, Audiology and Phoniatry G Ferreri, University of Rome La Sapienza, Piazzale Aldo Moro 5, Rome, Italy
    Eur J Histochem 54:e30. 2010
    ..We analyzed, together with the hepatocyte growth factor (HGF), the expression level of MIB-1 in samples harvested from patients affected by Reinke's edema, in ..
  34. pmc Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor
    L Naldini
    Department of Biomedical Sciences and Oncology, University of Torino, School Medicine, Italy
    EMBO J 10:2867-78. 1991
    ..b>Hepatocyte Growth Factor (HGF) is a powerful mitogen for hepatocytes and other epithelial tissues...
  35. ncbi Structural organization and the transcription initiation site of the human hepatocyte growth factor gene
    K Miyazawa
    Institute for Liver Research, Kansai Medical University, Osaka, Japan
    Biochemistry 30:9170-6. 1991
    The structural organization of the gene coding for human hepatocyte growth factor (hHGF) has been determined by seven overlapping lambda phage genomic clones including three clones that were previously characterized...
  36. ncbi Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
    D P Bottaro
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Science 251:802-4. 1991
    b>Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration...
  37. ncbi Cooperative actions of hepatocyte growth factor and 1,25-dihydroxyvitamin D3 in osteoblastic differentiation of human vertebral bone marrow stromal cells
    G D'Ippolito
    Geriatric Research, Education, and Clinical Center and Research Service, Veterans Affairs Medical Center, and Department of Medicine, University of Miami School of Medicine, Miami, FL 33125, USA
    Bone 31:269-75. 2002
    ..We previously reported that these factors, hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D(3) (vitD(3)), act together to increase alkaline phosphatase in ..
  38. pmc Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation
    Yu wen Zhang
    Laboratory of Molecular Oncology, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 100:12718-23. 2003
    b>Hepatocyte growth factor/scatter factor (HGF/SF), acting through the Met receptor, plays an important role in most human solid tumors, and inappropriate expression of this ligand-receptor pair is often associated with poor prognosis...
  39. ncbi Hepatocyte growth factor plays roles in the induction and autocrine maintenance of bone marrow stromal cell IL-11, SDF-1 alpha, and stem cell factor
    Yoshiko Matsuda-Hashii
    Department of Developmental Medicine, Osaka University, Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Exp Hematol 32:955-61. 2004
    ..In a previous study, we demonstrated that hepatocyte growth factor (HGF) is one of the cytokines constitutively produced from BM stromal cells, promoting hematopoiesis ..
  40. ncbi Activation of PI3K-Akt-GSK3beta pathway mediates hepatocyte growth factor inhibition of RANTES expression in renal tubular epithelial cells
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, Brown University Medical School, Providence, RI 02903, USA
    Biochem Biophys Res Commun 330:27-33. 2005
    b>Hepatocyte growth factor (HGF) was recently reported to ameliorate renal inflammation in a rat model of chronic renal failure. HGF exerted its action through suppression of RANTES expression in renal tubules...
  41. ncbi Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells
    Junhong Han
    Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    J Biol Chem 280:31548-56. 2005
    b>Hepatocyte growth factor (HGF) has an anti-proliferative effect on many types of tumor cell lines and tumors in vivo...
  42. ncbi Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors
    L E Kemp
    MRC Centre, Hills Road, Cambridge, UK
    Biochem Soc Trans 34:414-7. 2006
    The receptor tyrosine kinase Met and its ligand HGF/SF (hepatocyte growth factor/scatter factor) are essential in the signalling pathways required for embryogenesis and tissue regeneration...
  43. pmc HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway
    Maria E Ramos-Nino
    University of Vermont College of Medicine, Department of Pathology, 89 Beaumont Avenue HSRF 216, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 38:209-17. 2008
    The ligand hepatocyte growth factor/scatter factor (HGF) and its receptor tyrosine kinase, c-Met, are highly expressed in most human malignant mesotheliomas (MMs) and may contribute to their increased growth and viability...
  44. pmc Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor
    Thomas E Reznik
    The Kennedy Krieger Research Institute, Baltimore, MD 21205, USA
    Mol Cancer Res 6:139-50. 2008
    ..factor receptor (EGFR) and c-Met are frequently coexpressed in cancers, including those associated with hepatocyte growth factor (HGF) overexpression, such as malignant astrocytoma...
  45. pmc Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer
    Jihong Ma
    Division of Experimental Pathology, Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Invest 119:478-91. 2009
    ..We also suggest that DATE may be used as a potential genetic marker to identify individuals with a higher risk of developing breast cancer...
  46. pmc Alternative proteolytic processing of hepatocyte growth factor during wound repair
    Nils Buchstein
    Professor of Dermatology, Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Am J Pathol 174:2116-28. 2009
    ..We examined expression, integrity, and function of the proteins in the hepatocyte growth factor (HGF)/c-Met signaling pathway in normally healing and non-healing human skin wounds...
  47. pmc Hepatocyte growth factor protects endothelial cells against gamma ray irradiation-induced damage
    Shun Ying Hu
    Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China
    Acta Pharmacol Sin 30:1415-20. 2009
    ..To investigate the effect of HGF on proliferation, apoptosis and migratory ability of human vascular endothelial cells against gamma ray irradiation...
  48. doi Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA
    Kate A Owen
    Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, U K
    Biochem J 426:219-28. 2010
    HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity...
  49. pmc Co-overexpression of Met and hepatocyte growth factor promotes systemic metastasis in NCI-H460 non-small cell lung carcinoma cells
    Roya Navab
    Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Ontario, Canada
    Neoplasia 11:1292-300. 2009
    ..Met, the receptor for hepatocyte growth factor (HGF) is a receptor tyrosine kinase with demonstrated roles in regulating cellular proliferation, ..
  50. pmc Hepatocyte growth factor and the risk of ischemic stroke developing among postmenopausal women: results from the Women's Health Initiative
    Swapnil N Rajpathak
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Stroke 41:857-62. 2010
    b>Hepatocyte growth factor (HGF) is a potent angiogenic factor and may play a role in the development and progression of atherosclerotic lesions, the underlying mechanism of cardiovascular disease...
  51. doi Hepatocyte growth factor twenty years on: Much more than a growth factor
    Takahiro Nakamura
    Cancer Research Institute, Kanazawa University, Kakuma machi, Japan
    J Gastroenterol Hepatol 26:188-202. 2011
    ..1980s, the method for the cultivation of mature hepatocytes provided an opportunity for the discovery of hepatocyte growth factor (HGF) as a protein that is structurally and functionally different from other growth factors...
  52. pmc Identification of mannose receptor as receptor for hepatocyte growth factor β-chain: novel ligand-receptor pathway for enhancing macrophage phagocytosis
    Hiroyuki Ohnishi
    Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Biol Chem 287:13371-81. 2012
    b>Hepatocyte growth factor (HGF), a heterodimer composed of the α-chain and β-chain, exerts multifunctional actions for tissue repair and homeostasis via its receptor, MET...
  53. pmc Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
    L Naldini
    Department of Biomedical Sciences and Oncology, University of Torino, Italy
    EMBO J 11:4825-33. 1992
    ..b>Hepatocyte growth factor/scatter factor (HGF/SF) is a secretory product of stromal fibroblasts, sharing structural motifs with ..
  54. ncbi Regional localization of the hepatocyte growth factor (HGF) gene to human chromosome 7 band q21.1
    R Fukuyama
    Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan
    Genomics 11:410-5. 1991
    b>Hepatocyte growth factor (HGF) is a polypeptide involved in liver regeneration. Its amino acid sequence and gene structure are similar to those of coagulation-related serine proteases...
  55. ncbi Structure and function of hepatocyte growth factor
    T Nakamura
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Prog Growth Factor Res 3:67-85. 1991
    b>Hepatocyte growth factor (HGF), a potent mitogen for mature hepatocytes in primary culture, was first found in sera of partial hepatectomized rats and seems to be a hepatotrophic factor for liver regeneration which has not been purified ..
  56. ncbi Molecular cloning and expression of human hepatocyte growth factor
    T Nakamura
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Nature 342:440-3. 1989
    b>Hepatocyte growth factor (HGF) is the most potent mitogen for mature parenchymal hepatocytes in primary culture, and seems to be a hepatotrophic factor that acts as a trigger for liver regeneration after partial hepatectomy and liver ..
  57. ncbi Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants
    M Lyon
    Cancer Research Campaign, Christie Hospital, Manchester, United Kingdom
    J Biol Chem 269:11216-23. 1994
    We have demonstrated by affinity chromatography that hepatocyte growth factor (HGF) binds strongly to heparan sulfate (HS)...
  58. ncbi Hepatocyte growth factor and hepatocyte growth factor receptor in the lacrimal gland, tears, and cornea
    Q Li
    Department of Ophthalmology, University of Texas Southwestern Medical Center at Dallas, TX, USA
    Invest Ophthalmol Vis Sci 37:727-39. 1996
    The purpose of this study was to characterize the expression of hepatocyte growth factor (HGF) and HGF receptor proteins in lacrimal gland, tears, and cornea.
  59. ncbi Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity
    V Cioce
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:13110-5. 1996
    b>Hepatocyte growth factor/scatter factor (HGF/SF) stimulates cell proliferation, motility, and morphogenesis by activation of its receptor, the c-Met tyrosine kinase...
  60. ncbi Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease
    S L Lee
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Medical Center, Washington, DC 20007, USA
    J Biol Chem 275:36720-5. 2000
    ..81 and 4.89 microm, respectively. We further demonstrated that matriptase can convert hepatocyte growth factor/scattering factor to its active form, which can induce scatter of Madin-Darby canine kidney epithelial ..
  61. ncbi Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B
    Qinghua Zeng
    Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor 48109 1078, USA
    J Biol Chem 277:25203-8. 2002
    b>Hepatocyte growth factor (HGF), also known as a scatter factor, regulates a variety of biological activities including cell proliferation, survival, migration, and angiogenesis...
  62. ncbi Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4
    Michiyo Saimura
    Departments of Surgery and Oncology and Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka 812 8582, Japan
    Clin Cancer Res 8:3243-9. 2002
    NK4, composed of the N-terminal hairpin and subsequent four-kringle domains of hepatocyte growth factor (HGF), acts not only as a competitive antagonist of HGF but also as an inhibitor of angiogenesis...
  63. ncbi The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma
    P W B Derksen
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Leukemia 17:764-74. 2003
    ..An interesting candidate signal is hepatocyte growth factor/scatter factor (HGF), since its receptor Met is expressed on MM cells, while HGF is produced by BM ..
  64. ncbi Hepatocyte growth factor induces apoptosis through the extrinsic pathway in hepatoma cells: favouring role of hypoxia-inducible factor-1 deficiency
    Emanuela Matteucci
    Institute of General Pathology, School of Medicine, University of Milano, Via L Mangiagalli, 31 20133 Milano, Italy
    Oncogene 22:4062-73. 2003
    ..c4) lacking hypoxia-inducible factor-1 (HIF-1) activity, were differentially susceptible to apoptosis by hepatocyte growth factor (HGF). The c4 cells were 40% apoptotic 48 h after HGF treatment...
  65. pmc Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor
    Jennifer Stamos
    Department of Protein Engineering, Genentech Inc, South San Francisco, CA 94080, USA
    EMBO J 23:2325-35. 2004
    The Met tyrosine kinase receptor and its ligand, hepatocyte growth factor (HGF), play important roles in normal development and in tumor growth and metastasis...
  66. ncbi Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator
    Esther P M Tjin
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 104:2172-5. 2004
    ..A potential key signal in the evolution of MM is hepatocyte growth factor (HGF), which acts as a potent paracrine and/or autocrine growth factor and survival factor for MM cells...
  67. ncbi Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Am Soc Nephrol 15:2868-81. 2004
    b>Hepatocyte growth factor (HGF) has been shown to reduce renal injury in a variety of animal models of chronic renal disease...
  68. ncbi Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model
    Koushi Oh
    First Dept of Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G729-35. 2005
    b>Hepatocyte growth factor (HGF), a multifunctional cytokine, accelerates intestinal epithelial proliferation...
  69. ncbi Immunohistochemical expression of HGF, c-MET and transcription factor STAT3 in colorectal tumors
    M Trovato
    Dipartimento di Patologia Umana, Padiglione D, Policlinico Universitario G Martino, 98125 Messina, Italy
    Eur J Histochem 48:291-7. 2004
    By immunohistochemistry, we have investigated the expression of hepatocyte growth factor (HGF), HGF-R or c-met and the transcritor factor STAT3 in a series of 80 colorectal tumours (40 adenomas and 40 adenocarcinomas)...
  70. ncbi Hepatocyte growth factor; expression, concentration and biological activity in chronic leg ulcers
    Fariba Nayeri
    Division of Infectious Diseases, Faculty of Health Science, University Hospital, S 58185 Linkoping, Sweden
    J Dermatol Sci 37:75-85. 2005
    b>Hepatocyte growth factor (HGF) is a multifunctional cytokine that is involved in recovery process after organ injuries.
  71. pmc Hepatocyte growth factor gene therapy prevents radiation-induced liver damage
    Chau Hua Chi
    Department of Radiation Therapy and Oncology, Shin Kong Wu Ho Su Memorial Hospital, 95 Wen Chang Road, Shih Lin, Taipei, Taiwan, China
    World J Gastroenterol 11:1496-502. 2005
    ..To transfer human HGF gene into the liver of rats by direct electroporation as a means to prevent radiation-induced liver damage...
  72. ncbi Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction
    Munehisa Shimamura
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Osaka, Japan
    Hypertension 47:742-51. 2006
    ..To provide the new therapeutic options, we examined the effect of overexpression of hepatocyte growth factor (HGF) in the chronic stage of cerebral infarction by transferring the HGF gene into the brain using ..
  73. ncbi Family-based association analysis of hepatocyte growth factor (HGF) gene polymorphisms in high myopia
    Wei Han
    Department of Ophthalmology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China
    Invest Ophthalmol Vis Sci 47:2291-9. 2006
    To investigate the association of high myopia with polymorphisms in the hepatocyte growth factor (HGF) gene, a potential candidate for myopia development.
  74. ncbi Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines
    Takuya Watanabe
    Laboratory of Molecular and Cellular Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Cancer Res 4:499-510. 2006
    Activation of the c-Met receptor tyrosine kinase through its ligand, hepatocyte growth factor (HGF), promotes mitogenic, motogenic, and morphogenic cellular responses...
  75. ncbi Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue
    K Lindemann
    Department of Obstetrics and Gynaecology, Technical University, Munich, Germany
    Histopathology 51:54-62. 2007
    ..Our aim was to determine the expression of c-Met, its ligand hepatocyte growth factor/scatter factor (HGF/SF) and Her2/neu in ductal carcinoma in situ (DCIS) lesions of the breast (n = 39) by ..
  76. ncbi CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin
    Patrick A Singleton
    Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:30643-57. 2007
    ..In this study, we explored the regulation of hepatocyte growth factor (HGF)-mediated enhancement of EC barrier function via CD44 isoforms...
  77. ncbi Radiation-enhanced hepatocyte growth factor secretion in malignant glioma cell lines
    Chu Sheng-Hua
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University College of Medicine, Shanghai 201900, ROC China
    Surg Neurol 68:610-3; discussion 613-4. 2007
    ..The scope of this study is to investigate HGF secretion by malignant glioma cells with different radiosensitivity after irradiation...
  78. ncbi Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma
    Yunqing Li
    Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Lab Invest 88:98-111. 2008
    The growth factor hepatocyte growth factor (HGF), also known as scatter factor, and its tyrosine kinase receptor c-Met play important roles in medulloblastoma malignancy...
  79. doi Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer
    Yoshihiko Kitajima
    Department of Surgery, Saga University Faculty of Medicine, Saga, B49 8501 Japan
    Cancer Sci 99:1341-7. 2008
    Hepatocyte growth facor activator (HGFA) is a serine protease that converts hepatocyte growth factor (HGF) into its active form...
  80. doi Predictive value of plasma hepatocyte growth factor/scatter factor levels in patients with clinically localized prostate cancer
    Amit Gupta
    Department of Urology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Clin Cancer Res 14:7385-90. 2008
    b>Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional cytokine that is involved in cancer growth, motility, invasion, and angiogenesis...
  81. doi High myopia is not associated with the SNPs in the TGIF, lumican, TGFB1, and HGF genes
    Panfeng Wang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Invest Ophthalmol Vis Sci 50:1546-51. 2009
    ..This study was conducted to verify the reported positive association results by analysis of subjects from the same region...
  82. doi Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells
    Eric Sulpice
    Institut des Vaisseaux et du Sang, INSERM U965, Universite Paris 7, Hopital Lariboisiere, Paris, France
    Biol Cell 101:525-39. 2009
    ..HGF (hepatocyte growth factor) is a pleiotropic cytokine that may promote VEGF-A-driven angiogenesis, although the signalling ..
  83. doi Serum hepatocyte growth factor is increased in Hashimoto's thyroiditis whether or not it is associated with nodular goiter as compared with healthy non-goitrous individuals
    R M Ruggeri
    Unit of Endocrinology, Clinical Experimental Department of Medicine and Pharmacology, University of Messina, Messina, Italy
    J Endocrinol Invest 32:465-9. 2009
    ..Some growth factors and cytokines are known to cooperate with TSH in thyroid nodular growth, but few data are available on their circulating levels in Hashimoto's thyroiditis (HT)...
  84. pmc Hepatocyte growth factor and myopia: genetic association analyses in a Caucasian population
    Tammy Yanovitch
    Duke University Center for Human Genetics, 595 La Salle Street, Durham, NC 27710, USA
    Mol Vis 15:1028-35. 2009
    b>Hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (C-MET) genes have previously been reported to be associated with myopia in Asian family-based and case-control association studies, respectively...
  85. doi Low-dose simultaneous delivery of adenovirus encoding hepatocyte growth factor and vascular endothelial growth factor in dogs enhances liver proliferation without systemic growth factor elevation
    Hussein M Atta
    Department of Surgery, Faculty of Medicine, Minia University, Minia, Egypt
    Liver Int 29:1022-30. 2009
    b>Hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) gene transfer proved to enhance liver regeneration...
  86. pmc Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association
    Katsuya Sakai
    Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 284:22491-9. 2009
    NK4, a fragment of hepatocyte growth factor (HGF), exerts bifunctional action as a competitive antagonist against HGF and its receptor c-Met and an angiogenesis inhibitor. Here we studied the anti-angiogenic mechanism of NK4...
  87. doi Hepatocyte growth factor suppresses tumor cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 protein expression
    Bian Li-juan
    Department of Pathology, 1st Affiliated Hospital, Sun Yat Sen University, 58, Zhongshan Road II, Guangzhou 510080, China
    Pathol Res Pract 205:828-37. 2009
    b>Hepatocyte growth factor (HGF) is a multifunctional cytokine, but cell apoptosis related to HGF in nasopharyngeal carcinoma (NPC) and the potential mechanisms involved have not yet been identified...
  88. doi Role of the hepatocyte growth factor gene in refractive error
    Sundar Veerappan
    Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Australia
    Ophthalmology 117:239-45.e1-2. 2010
    ..Several genetic loci have been associated with myopia but none to date have been reported for hypermetropia. We investigated the hepatocyte growth factor (HGF) as a candidate gene influencing these 2 refractive error states.
  89. doi Altered expression of E-cadherin by hepatocyte growth factor and effect on the prognosis of nasopharyngeal carcinoma
    Li Qiong Xie
    Department of Pathology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Ann Surg Oncol 17:1927-36. 2010
    b>Hepatocyte growth factor (HGF)-related E-cadherin expression and prognosis of patients with nasopharyngeal carcinoma (NPC) are not fully understood...
  90. doi Inhibition of HGF/cMET expression prevents distant recurrence of rectal cancer after preoperative chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Int J Oncol 40:583-91. 2012
    b>Hepatocyte growth factor (HGF) and its receptor cMET play an important role in tumor proliferation, invasion and metastasis...
  91. pmc Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus
    Kathryn P Burdon
    Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia
    Invest Ophthalmol Vis Sci 52:8514-9. 2011
    ..Although several genomic regions have been linked to rare familial forms of keratoconus, no genes have yet been definitively identified for common forms of the disease...
  92. pmc Hepatocyte growth factor (HGF) autocrine activation predicts sensitivity to MET inhibition in glioblastoma
    Qian Xie
    Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Proc Natl Acad Sci U S A 109:570-5. 2012
    ..We investigated in vivo glioblastoma models characterized by hepatocyte growth factor (HGF) autocrine or paracrine activation, or by MET or EGFR amplification, for their susceptibility to MET ..
  93. pmc Endophenotyping reveals differential phenotype-genotype correlations between myopia-associated polymorphisms and eye biometric parameters
    Jian Huan Chen
    Joint Shantou International Eye Center, Shantou University and The Chinese University of Hong Kong, Shantou, China
    Mol Vis 18:765-78. 2012
    ..in myopia-associated single nucleotide polymorphisms (SNPs) of the gap junction protein delta 2 (GJD2), insulin-like growth factor-1 (IGF1) and hepatocyte growth factor (HGF) genes in two geographically different Chinese cohorts.
  94. pmc Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
    Ravid Straussman
    The Eli and Edythe L Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 487:500-4. 2012
    ..Proteomic analysis showed that stromal cell secretion of hepatocyte growth factor (HGF) resulted in activation of the HGF receptor MET, reactivation of the mitogen-activated protein ..
  95. pmc Microvesicles derived from human Wharton's jelly mesenchymal stem cells promote human renal cancer cell growth and aggressiveness through induction of hepatocyte growth factor
    Tao Du
    Department of Urology, Henan Provincial People s Hospital, Zhengzhou, P R China
    PLoS ONE 9:e96836. 2014
    ..RNase pre-treatment abrogated all effects of MVs. In summary, induction of HGF synthesis via RNA transferred by MVs activating AKT and ERK1/2 signaling is one of crucial contributors to the pro-tumor effect. ..
  96. pmc Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding
    N A Lokker
    Department of Cell Genetics, Genentech, Inc, South San Francisco, CA 94080
    EMBO J 11:2503-10. 1992
    b>Hepatocyte growth factor (HGF) is a potent mitogen for parenchymal liver, epithelial and endothelial cells. Structurally, it has similarities to kringle-containing serine proteases, although it does not possess proteolytic activity...
  97. ncbi An alternatively processed mRNA generated from human hepatocyte growth factor gene
    K Miyazawa
    Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Eur J Biochem 197:15-22. 1991
    We recently reported the isolation and sequencing of cDNA for human hepatocyte growth factor (hHGF) [Miyazawa, K., Tsubouchi, H., Naka, D., Takahashi, K., Okigaki, M., Arakaki, N., Nakayama, H., Hirono, S., Sakiyama, O., Takahashi, K...
  98. ncbi Novel function of prostaglandins as inducers of gene expression of HGF and putative mediators of tissue regeneration
    K Matsumoto
    Division of Biochemistry, Osaka University Medical School
    J Biochem 117:458-64. 1995
    ..Addition of PGs to cultures of human skin fibroblasts led to a marked induction of the production of hepatocyte growth factor (HGF)...
  99. ncbi c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination
    Taher E I Taher
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 169:3793-800. 2002
    b>Hepatocyte growth factor/scatter factor (HGF) and its receptor tyrosine kinase Met are key regulators of epithelial motility and morphogenesis...
  100. ncbi Clinical significance of lymphocytes hepatocyte growth factor mRNA expression in patients after liver transplantation
    K Dudek
    Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland
    Transplant Proc 39:2788-92. 2007
    b>Hepatocyte growth factor (HGF) plays a key role in the regulation of liver regeneration after hepatocyte damage. Changes in HGF gene expression reflect the status of the regeneration process.
  101. ncbi Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils
    Alain Grenier
    Laboratoire de Biochimie, Hôpital de Montfermeil, Montfermeil, France
    Blood 99:2997-3004. 2002
    b>Hepatocyte growth factor (HGF), a heparin-binding factor, is synthesized as a single-chain inactive precursor (pro-HGF), which is converted by proteolysis to an active heterodimer (mature HGF)...

Research Grants69

  1. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hepatocyte growth factor (HGF) is a pleiotropic cytokine that promotes cell proliferation, motility, survival, and morphogenesis...
  2. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
    ..c-Met, also known as the hepatocyte growth factor receptor, is a receptor tyrosine kinase that regulates cell proliferation, differentiation, migration and ..
  3. Pilot Clinical Study in Renal Transplantation
    Weizhong Cai; Fiscal Year: 2010
    ..b>Hepatocyte growth factor (HGF), also known as scatter factor (CF), is a renotrophic growth factor that exerts tissue protective ..
  4. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
    ..Significant evidence suggests that scatter factor / hepatocyte growth factor (SF/HGF), exerts direct hepatoprotective effects and can potentially be used as a therapeutic in ALF...
  5. HGF/HGFR Axis and Fatty Liver Disease
    Reza Zarnegar; Fiscal Year: 2013
    ..data indicate that, in hepatocytes, the insulin receptor (IR) tyrosine kinase crosstalks with the Hepatocyte Growth Factor Receptor (HGFR) tyrosine kinase (also known as Met) through intermolecular tyrosine phosphorylation...
  6. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
    ..apoptosis by activating the phosphatidylinositol 3-kinase (PI3K) signal transduction pathway, and (d) hepatocyte growth factor (HGF), a growth factor with pleiotropic effects on tumor growth...
  7. HGF Signaling in Kidney Repair
    Lloyd G Cantley; Fiscal Year: 2012
    ..b>Hepatocyte growth factor is highly upregulated following acute tubular injury and has been shown in vitro to stimulate cell ..
  8. Safety and efficacy of optimized AAV3 vectors in murine and NHP livers
    Arun Srivastava; Fiscal Year: 2013
    ..AAV3 vectors also transduce primary human hepatocytes efficiently, as they utilize human hepatocyte growth factor receptor (HGFR) as a cellular co-receptor...
  9. Reza Zarnegar; Fiscal Year: 2015
    ..The Hepatocyte Growth Factor Receptor (HGFR) known as Met is a transmembrane receptor tyrosine kinase (RTK) that plays an important ..
  10. Secreted Wnt Inhibitors in the Biology of Osteosarcoma
    Bang H Hoang; Fiscal Year: 2010
    ..pro-invasive pathways in OS: (1) Transcriptional repressors Slug and Twist, (2) MMP-2 and 9, and (3) the hepatocyte growth factor receptor Met...
  11. FRANCISCO FERNANDEZ-LIMA; Fiscal Year: 2014
    ..g., expression of CD4 antigen and hepatocyte growth factor receptor (c-met) from Immune cells (Molt-3) and hepatocytes) to characterize the instrument performance (..
  12. Cellular Response to cMet Endocytosis
    Lisa A Elferink; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The Hepatocyte Growth Factor Receptor (cMet) is a receptor tyrosine kinase critical for normal cellular responses, such as cell growth, survival and motility...
  13. Anti-Fibrotic Therapy for Pulmonary Fibrosis
    Latha Paka; Fiscal Year: 2007
    ..Recent studies have identified hepatocyte growth factor (HGF) as an antifibrogenic agent that protects against transforming growth factor (TGFbeta) mediated ..
  14. LIVER REGENERATION AND GROWTH FACTORS
    SANDRA DEGEN; Fiscal Year: 2000
    ..a human and rodent gene for which the cDNA codes for a protein with a domain structure similar to hepatocyte growth factor (HGF)...
  15. Small Molecule Therapeutics for Renal Disease
    Prakash Narayan; Fiscal Year: 2010
    ..Scatter factor/hepatocyte growth factor (SF/HGF) is a renotrophic factor that is mitogenic for renal epithelial cells, exerts antifibrotic ..
  16. Regulating HGF Receptor Internalization
    LISA ELFERINK; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The importance of Hepatocyte Growth Factor Receptor signaling in normal and pathological conditions is well established...
  17. Namita Roy-Chowdhury; Fiscal Year: 2016
    ..hepatic irradiation and mitotic stimulation by a single injection of an adenovector, expressing hepatocyte growth factor to induce repopulation of the liver with the transplanted hepatocytes...
  18. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..Recent studies suggest that hepatocyte growth factor (HGF), a pleiotropic cytokine, has multiple activities that lead to lung regeneration...
  19. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..b>Hepatocyte growth factor (HGF) increases 2-cell proliferation and promotes revascularization of islets, while interleukin-1 ..
  20. Bombesin-Activated Carcinoma Associated Fibroblasts in Colorectal Cancer
    Celia Chao; Fiscal Year: 2013
    ..activation of the MEK/ERK pathway, regulation of COX-2 promoter activity and upregulation of Hepatocyte Growth Factor in CAFs...
  21. Novel Anti-fibrotic Therapy for Diabetic Nephropathy
    Susan C Wright; Fiscal Year: 2013
    ..a heterodimeric fusion protein consisting of the CTGF antagonist, CCN3, and the alpha chain fragment of hepatocyte growth factor (HGF) both fused to the N-terminus if the Fc portion of IgG...
  22. Hepatocyte Growth Factor and the Pancreatic Beta Cell
    Adolfo Garcia-Ocana; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have previously shown that hepatocyte growth factor (HGF) has beneficial effects in beta cell proliferation, function and islet transplantation...
  23. The role of c-Met expression in melanoma growth and migration
    AMBER LEIGH SHADA; Fiscal Year: 2010
    ..c-Met and its ligand, hepatocyte growth factor (HGF), may be upregulated in metastatic melanoma and are implicated in invasion and clinical disease ..
  24. STEVEN HERBERT ABMAN; Fiscal Year: 2015
    ..data, we further hypothesize that the effects of VEGF on lung structure are dependent upon stimulation of hepatocyte growth factor and enhanced retinoic acid production by vascular endothelium ("angiocrine factors")...
  25. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..include tumor necrosis factor (TNF)-??and interleukin (IL)-6, which are produced by Kupffer cells, and hepatocyte growth factor (HGF), which is produced primarily by stellate cells...
  26. Extracellular Proteinases in Ocular Neovascularization
    Arup Das; Fiscal Year: 2010
    ..Other factors may play important roles during this process including the hepatocyte growth factor (HGF) which has received little attention in terms of its function in ocular angiogenesis...
  27. Mechanisms of Forebrain Development
    Elizabeth M Powell; Fiscal Year: 2010
    ..The hepatocyte growth factor/scatter factor (HGF/SF) signaling system via its receptor, MET, possesses multiple activities in cellular ..
  28. CYTOSKELETAL REGULATION OF LUNG ENDOTHELIAL PATHOBIOLOGY
    Joe G N Garcia; Fiscal Year: 2012
    ..of signaling to the actomyosin cytoskeleton evoked when c-Met, a tyrosine kinase receptor, is ligated by hepatocyte growth factor, a major barrier-regulatory pathway with strong potential for receptor transactivation...
  29. Shahin Rafii; Fiscal Year: 2016
    ..kinase receptor (VEGFR2) and Id1 pathway in LSECs upregulated the angiocrine expression of Wnt2 and hepatocyte growth factor (HGF) stimulating hepatic proliferation...
  30. Targeting RON Receptor Signaling in Pancreatic Cancer
    Andrew M Lowy; Fiscal Year: 2010
    ..We have shown that activation of RON receptor signaling by its specific ligand, hepatocyte growth factor-like protein (HGFL), induces apoptotic resistance, migration, invasion, association with EGFR, and VEGF ..
  31. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2010
    ..Am 3 will study hepatocyte growth factor (HGF) regulation of CYP7A1 gene transcription to identify signaling pathway and crosstalk with insulin ..
  32. SHELLY CHI LOO LU; Fiscal Year: 2016
    ..Examine SAMe's regulation of HGF-mediated hepatocyte proliferation. Hepatocyte growth factor (HGF) activates AMP kinase (AMPK), which is required for hepatocyte proliferation...
  33. Serpil C Erzurum; Fiscal Year: 2016
    ..data show that the PAH PAEC secrete the potent growth- stimulatory &bone marrow-mobilizing hepatocyte growth factor (HGF)...
  34. Georgios I Papachristou; Fiscal Year: 2014
    ..48 hours from admission to measure the 5 biomarkers (tumor necrosis factor-a receptor-1, interleukin-8, hepatocyte growth factor, angiopoietin-2, resistin) using Luminex technology...
  35. Pat Levitt; Fiscal Year: 2016
    ..MET and its ligand, hepatocyte growth factor (HGF), have been implicated in the development and maturation of neuronal circuits in vitro...
  36. Alex Kentsis; Fiscal Year: 2015
    ..I discovered that shRNA mediated depletion of hepatocyte growth factor (HGF), ligand of the receptor tyrosine kinase MET, specifically inhibits growth of AML but not other ..
  37. MICAH TAUBE WEBSTER; Fiscal Year: 2015
    ..c-Met encodes a receptor tyrosine kinase. Activation by its ligand, Hepatocyte Growth Factor (HGF), triggers multiple signaling cascades that modulate cell survival, proliferation, and migration of ..
  38. Steven N Steinway; Fiscal Year: 2015
    ..Recently, we have demonstrated that Hepatocyte Growth Factor (HGF) is a primary initiator of EMT in multiple liver cancer models...
  39. Regulation of hepcidin and iron metabolism in liver disease
    Julia Goodnough; Fiscal Year: 2011
    ..Candidates for the suppressor of hepcidin include hepatocyte growth factor (HGF) and growth and differentiation factor 15 (GDF15)...
  40. Susan E Waltz; Fiscal Year: 2016
    ..However, the degree of dependency of the Ron ligand, hepatocyte growth factor-like protein (HGFL), in this model remains unknown...
  41. Hepatocyte - Based Therapies of Primary Hyperoxaluria 1
    Namita Roy Chowdhury; Fiscal Year: 2010
    ..advantage to transplanted hepatocytes, using preparative hepatic X-irradiation (HIR) and expressing hepatocyte growth factor (HGF) as a mitotic stimulant...
  42. Discovering Microenvironments Promoting Pathological EMT using Array Technology
    Naira Serobyan; Fiscal Year: 2012
    ..epidermal growth factor (EGF), CTGF, insulin-like growth factor-2 (IGF-II), interleukin-1 (IL-1), hepatocyte growth factor (HGF), and Wnt ligands...
  43. Anna Birukova; Fiscal Year: 2016
    ..Our novel data show that MT-mediated signaling is directly involved in the EC barrier preservation by hepatocyte growth factor (HGF), a circulating molecule with proven protective effects in the models of acute ling injury (ALI)...
  44. Guy Howard; Fiscal Year: 2015
    ..proposed studies on human mesenchymal stem cell (MSC) differentiation and maturation catalyzed by hepatocyte growth factor (HGF) and 1,25-dihydroxyvitamin D (1,25OHD), the most active metabolite of vitamin D...
  45. Jamie L Renbarger; Fiscal Year: 2016
    ..adult population [interleukin-2- receptor-alpha, tumor-necrosis-factor-receptor-1, interleukin-8, hepatocyte growth factor, elafin, a skin-specific marker, regenerating islet-derived 3-alpha, a gastro-intestinal specific marker, ..
  46. Micromagnetic Aptamer PCR System for Ultrasensitive Multiplexed Protein Detection
    HYONGSOK TOM SOH; Fiscal Year: 2010
    ..will demonstrate simultaneous detection of three cancer markers, platelet derived growth factor (PDGF), hepatocyte growth factor (HGF), and thyroid transcription factor (TTF1), at femtomolar concentration levels directly from serum...
  47. Protease Pathways in the Gastrointestinal Tract
    Toni M Antalis; Fiscal Year: 2010
    ..protease zymogens, including urokinase plasminogen activator (uPA) and prostasin, and also activates pro-hepatocyte growth factor (HGF), which serves as a ligand for c-met, a receptor tyrosine kinase involved in gastrointestinal repair...
  48. Chen Yong Lin; Fiscal Year: 2014
    ..We have shown that in these tissues, Hepatocyte Growth factor Activator Inhibitor-1 (HAI-1), a kunitz-type protease inhibitor, is required for the normal regulation of ..
  49. The Role of Hepatocyte Growth Factor Signaling Airspace Homeostasis
    Enid R Neptune; Fiscal Year: 2011
    ..If successful, these studies will provide an extensive therapeutic armamentarium to support regenerative alveolarization for a wide range of pulmonary disorders. ..
  50. A Pilot Clinical Study in Acute STEMI
    Weizhong Cai; Fiscal Year: 2011
    ..Scatter factor / hepatocyte growth factor (SF/HGF) is an endogenous cell survival factor that exerts both acute and chronic cardioprotective ..
  51. Po Han Chen; Fiscal Year: 2016
    ..The overall goal of the proposal is to elucidate the molecular basis of recognition/activation between hepatocyte growth factor (HGF) and its receptor MET receptor tyrosine kinase (MET RTK)...
  52. Simltaneous recruitment of cardiac and bone marrow stem cells for cardiac repair
    Khawaja H Haider; Fiscal Year: 2012
    ..We anticipate that transplantation of Sca-1+ cells genetically modified to overexpress hepatocyte growth factor (HGF), stromal cell derived factor-11 (SDF-11) and insulin-like growth factor (IGF-1) will develop ..
  53. Cun Yu Wang; Fiscal Year: 2016
    ..During the last funding period, we have demonstrated that hepatocyte growth factor (HGF)/c-Met inhibits anoikis induced by a loss of cell-matrix interaction and promotes SCC progression...
  54. delta-Catenin and Cell-Cell Adhesion in Prostate Cancer
    Qun Lu; Fiscal Year: 2010
    ..Specific Aim 1 will determine how 8-catenin promotes cell growth/survival and motility in response to the hepatocyte growth factor and/or androgen using CWR22 tumor xenografts and their derived cell lines...
  55. Genetic Control of Ureter and Kidney Development
    FRANKLIN D COSTANTINI; Fiscal Year: 2013
    ..We therefore investigate the roles of several candidates, including fibroblast growth factors (FGFs) and hepatocyte growth factor (HGF), in these processes...
  56. Novel Neuroprotective/Restorative Therapy for Ischemic Stroke
    David E Smith; Fiscal Year: 2012
    ..b>Hepatocyte growth factor (HGF) a neurotrophic factor, reduces cerebral infarct size, augments cerebral blood flow and promotes ..
  57. Lisa M Curtis; Fiscal Year: 2015
    ..the applicant in the process used to study signaling pathways, particularly as applied to the study of hepatocyte growth factor (HGF) and stromal cell-derived factor 1 (SDF-1) , two known modulators of the pathophysiology of cellular ..
  58. Unique Clinical Study on DGF Using Paired Kidneys
    Weizhong Cai; Fiscal Year: 2012
    ..Angion Biomedica is developing BB3, a small molecule hepatocyte growth factor mimetic that exhibits significant tissue protective activity in numerous models of acute renal injury...
  59. Studies on the Post-translational processing of MUC1
    Michael A Hollingsworth; Fiscal Year: 2012
    ..In contrast to the results with PDGF-BB, stimulation of pancreatic tumor cells with hepatocyte growth factor (HGF) under conditions of MUC1 overexpression decreases cell invasive through a mechanism in which MUC1 ..
  60. Jennifer R Cochran; Fiscal Year: 2014
    ..agents we used the N- terminal and first Kringle domain (NK1) of the natural Met activating ligand, hepatocyte growth factor (HGF), as a basis for engineering potent Met receptor antagonists...
  61. Phase I Clinical Trial for BB3
    Weizhong Cai; Fiscal Year: 2009
    ..b>Hepatocyte growth factor (HGF), also know as scatter factor (SF), is an endogenous cell survival factor that exerts ..
  62. Development of Small Molecule Mimetics of hepatocyte Growth Factor (HGF)
    ANNE MUESCH; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The naturally-occurring cytokine hepatocyte growth factor (HGF), also known as scatter factor(SF), is active in numerous tissues throughout the body, participating in the regulation of angiogenesis, ..
  63. HGF receptor and renal cell survival and differentiation
    Youhua Liu; Fiscal Year: 2006
    ..renewal application is a continuation of our long-term effects to understand the role and mechanism of hepatocyte growth factor (HGF) and its c-met receptor in normal and diseased kidney...
  64. Renal Injury Prevention by SF/HGF-like Small Molecules
    Prakash Narayan; Fiscal Year: 2004
    ..Scatter factor, also known as hepatocyte growth factor (SF/HGF), is a pleiotropic growth factor that induces the activation and proliferation of diverse cell ..
  65. HGF RECEPTOR GENE REGULATION AND RENAL GROWTH
    Youhua Liu; Fiscal Year: 2003
    ..an independent molecular nephrology research program working on the regulation and functions of hepatocyte growth factor (HGF) receptor (c- met) in the kidney...
  66. Novel Immunoadhesin Molecule for Cancer Therapy
    JAMES LARRICK; Fiscal Year: 2007
    ..studies in preparation for conducting clinical trials in cancer of an immunoadhesin that neutralizes hepatocyte growth factor (HGF)...
  67. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..data show that the PAH PAEC secrete the potent growth- stimulatory &bone marrow-mobilizing hepatocyte growth factor (HGF)...
  68. IMPROVED METHODS FOR IN VIVO HEPATIC GENE THERAPY
    KATHERINE PONDER; Fiscal Year: 2006
    ..We have demonstrated during the previous funding period that hepatocyte growth factor (HGF) can efficiently induce hepatocyte replication in rodents...
  69. Protection from Atherosclerosis by c-Met Agonist
    Latha Paka; Fiscal Year: 2003
    ..Scatter factor (SF) also known as hepatocyte growth factor (HGF) has been identified as a powerful endothelial specific anti apoptotic and mitogenic factors...