hBD-2

Summary

Gene Symbol: hBD-2
Description: defensin beta 4A
Alias: BD-2, DEFB-2, DEFB102, DEFB2, DEFB4, HBD-2, SAP1, beta-defensin 4A, beta defensin-2, defensin, beta 2, defensin, beta 4, skin-antimicrobial peptide 1
Species: human

Top Publications

  1. ncbi Human beta-defensin-2
    J M Schroder
    Department of Dermatology, University of Kiel, Germany
    Int J Biochem Cell Biol 31:645-51. 1999
  2. ncbi A novel murine beta -defensin expressed in tongue, esophagus, and trachea
    H P Jia
    Departments of Pediatrics, Genetics Ph D Program, and Microbiology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 275:33314-20. 2000
  3. ncbi Production of beta-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural protein
    A Takahashi
    Department of Nutrition, School of Medicine, University of Tokushima, Japan
    FEBS Lett 508:484-8. 2001
  4. doi Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis
    Minhao Wu
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 183:8054-60. 2009
  5. ncbi The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    J Immunol 175:1776-84. 2005
  6. pmc Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells
    Haa Yung Lee
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 8:87. 2008
  7. doi Toll-like receptor-4 (TLR4) mediates human beta-defensin-2 (HBD-2) induction in response to Chlamydia pneumoniae in mononuclear cells
    Caterina Romano Carratelli
    Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy
    FEMS Immunol Med Microbiol 57:116-24. 2009
  8. ncbi Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of beta-defensin 2 via TLR2 and TLR4
    Silvia Gariboldi
    Mucosal Immunity Laboratory, Department of Human Morphology, Universita degli Studi di Milano, Milan, Italy
    J Immunol 181:2103-10. 2008
  9. doi Modulation of human beta-defensin-2 expression by 17beta-estradiol and progesterone in vaginal epithelial cells
    June Hyun Han
    Department of Urology, KEPCO Medical Foundation Hanil General Hospital, Seoul, Republic of Korea
    Cytokine 49:209-14. 2010
  10. doi Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2
    Johann Röhrl
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Division of Basic Science, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 184:6688-94. 2010

Research Grants

  1. GINGIVAL EPITHELIAL CELL ANTIMICROBIAL PEPTIDES
    Aaron Weinberg; Fiscal Year: 2002
  2. C.ALBICANS REGULATION BETA-DEFENSINS IN ORAL EPITHELIA
    Aaron Weinberg; Fiscal Year: 2002
  3. FUNCTION OF B-DEFENSINS IN COMMON ORAL INFECTIONS
    Janet Guthmiller; Fiscal Year: 2002
  4. MODULATION OF BETA-DEFENSINS BY MATRILYSIN
    Carole Wilson; Fiscal Year: 2001
  5. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
  6. HIGH-DOSE VITAMIN D AND ANTIMICROBIAL PEPTIDE EXPRESSION IN LUNG FAILURE
    Thomas R Ziegler; Fiscal Year: 2012
  7. Roles of IL-17-induced gene expression in airway epithelial host defense
    Reen Wu; Fiscal Year: 2013
  8. Sharof M Tugizov; Fiscal Year: 2016
  9. Innate Immunity in Otitis Media Pathogenesis
    David J Lim; Fiscal Year: 2013
  10. IMMUNITY TO STDS IN THE HUMAN MALE GENITAL TRACT
    Deborah Anderson; Fiscal Year: 2004

Detail Information

Publications214 found, 100 shown here

  1. ncbi Human beta-defensin-2
    J M Schroder
    Department of Dermatology, University of Kiel, Germany
    Int J Biochem Cell Biol 31:645-51. 1999
    ....
  2. ncbi A novel murine beta -defensin expressed in tongue, esophagus, and trachea
    H P Jia
    Departments of Pediatrics, Genetics Ph D Program, and Microbiology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 275:33314-20. 2000
    ..Identification of murine beta-defensins provides an opportunity to understand further the role of these peptides in host defense through animal model studies and the generation of beta-defensin-deficient animals by gene targeting...
  3. ncbi Production of beta-defensin-2 by human colonic epithelial cells induced by Salmonella enteritidis flagella filament structural protein
    A Takahashi
    Department of Nutrition, School of Medicine, University of Tokushima, Japan
    FEBS Lett 508:484-8. 2001
    ..We conclude that FliC increased [Ca(2+)](in) via inositol 1,4,5-trisphosphate, which was followed by up-regulating hBD-2 mRNA expression via an NF-kappaB-dependent pathway...
  4. doi Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis
    Minhao Wu
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 183:8054-60. 2009
    ..Collectively, the data provide evidence that mBD2 and mBD3 together promote resistance against corneal infection...
  5. ncbi The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    J Immunol 175:1776-84. 2005
    ..Thus, the ability of hBDs and LL-37 to induce IL-18 secretion by keratinocytes provides a new mechanism for these peptides in innate immunity and an understanding of their role in the pathogenesis of skin disorders...
  6. pmc Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells
    Haa Yung Lee
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 8:87. 2008
    ..We believe that this report is the first attempt to elucidate NTHi induced beta-defensin expression in airway mucosa, which includes the middle ear...
  7. doi Toll-like receptor-4 (TLR4) mediates human beta-defensin-2 (HBD-2) induction in response to Chlamydia pneumoniae in mononuclear cells
    Caterina Romano Carratelli
    Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy
    FEMS Immunol Med Microbiol 57:116-24. 2009
    ..An understanding of the importance of the TLR-mediated antimicrobial mechanisms may provide new avenues for the development of therapeutic regimens aimed at activating the body's own defenses by stimulating TLR-dependent pathways...
  8. ncbi Low molecular weight hyaluronic acid increases the self-defense of skin epithelium by induction of beta-defensin 2 via TLR2 and TLR4
    Silvia Gariboldi
    Mucosal Immunity Laboratory, Department of Human Morphology, Universita degli Studi di Milano, Milan, Italy
    J Immunol 181:2103-10. 2008
    ....
  9. doi Modulation of human beta-defensin-2 expression by 17beta-estradiol and progesterone in vaginal epithelial cells
    June Hyun Han
    Department of Urology, KEPCO Medical Foundation Hanil General Hospital, Seoul, Republic of Korea
    Cytokine 49:209-14. 2010
    ....
  10. doi Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2
    Johann Röhrl
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Division of Basic Science, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 184:6688-94. 2010
    ..Our data indicate that hBD2 and hBD3, together with their mouse orthologs (beta-defensin 4 and 14), are chemotactic for a broad spectrum of leukocytes in a CCR6- and CCR2-dependent manner...
  11. doi Interaction of human β-defensin 2 (HBD2) with glycosaminoglycans
    Emily S Seo
    EaStCHEM, School of Chemistry, The University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JJ, UK
    Biochemistry 49:10486-95. 2010
    ..The formation of FX-bridged HBD2 dimers exhibited features of a cooperative binding mechanism. In contrast, the complex with DSdp6 was found to be mostly monomeric...
  12. pmc Modulation of early β-defensin-2 production as a mechanism developed by type I Toxoplasma gondii to evade human intestinal immunity
    Vijay Morampudi
    Toxoplasmosis Laboratory, Operational Direction Communicable and Infectious Diseases, Scientific Institute of Public Health, 1180 Brussels, Belgium
    Infect Immun 79:2043-50. 2011
    ..These findings strongly support the modulation of early β-defensin 2 expression as a mechanism used by type I T. gondii parasites to mediate immune evasion...
  13. pmc Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin
    Miriam Schlee
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Infect Immun 75:2399-407. 2007
    ..coli strain ATCC 25922. H1 flagellin antiserum abrogated hBD-2 expression induced by flagellin as well as E. coli Nissle 1917 supernatant, confirming that flagellin is the major stimulatory factor of E. coli Nissle 1917...
  14. ncbi Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation
    L Liu
    Departments of Medicine and Pathology and the Will Rogers Institute for Pulmonary Research, UCLA School of Medicine, Los Angeles, CA, USA
    Gene 222:237-44. 1998
    ..The HBD-2 gene is the first member of the human defensin family that is locally inducible by inflammation...
  15. ncbi Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin
    R S Ali
    Center for Cutaneous Research, St Bartholomew s and The Royal London Hospital, School of Medicine and Dentistry, Whitechapel, London, UK
    J Invest Dermatol 117:106-11. 2001
    ..The localization of human beta defensins to the outer layer of the skin is consistent with the hypothesis that human beta defensins play an essential part in cutaneous innate immunity...
  16. pmc Keratinocyte expression of human beta defensin 2 following bacterial infection: role in cutaneous host defense
    James G H Dinulos
    Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Clin Diagn Lab Immunol 10:161-6. 2003
    Human beta defensin 2 (hbetaD-2) is thought to play an important role in cutaneous immune defense...
  17. ncbi In human epidermis, beta-defensin 2 is packaged in lamellar bodies
    A Oren
    Department of Medicine and Pathology, Geffen School of Medicine at University of California, at Los Angeles, Los Angeles, CA 90095, USA
    Exp Mol Pathol 74:180-2. 2003
    ..These findings suggest that HBD-2 is released with the contents of the LBs. Along with other investigations, our findings indicate that the lipid "permeability" barrier of the skin contains antimicrobial substances...
  18. ncbi Airway epithelia regulate expression of human beta-defensin 2 through Toll-like receptor 2
    Xiaorong Wang
    Department of Medicine, Medical Genetics Division, University of Pennsylvania School of Medicine, Philadelphia, USA
    FASEB J 17:1727-9. 2003
    ..These data provide convincing evidence that up-regulation of hBD2 can be induced through hTLR2-mediated NFkappaB/IkappaB pathway in the human airway epithelial cells...
  19. ncbi Malassezia furfur induces the expression of beta-defensin-2 in human keratinocytes in a protein kinase C-dependent manner
    Giovanna Donnarumma
    Department of Experimental Medicine Microbiology and Clinical Microbiology, Faculty of Medicine and Surgery, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Arch Dermatol Res 295:474-81. 2004
    ..Our results suggest that beta-defensins are integral components of innate host defenses. They play an essential part in the resistance of the human skin surfaces against M. furfur uptake and other microbial invasion...
  20. ncbi MEF up-regulates human beta-defensin 2 expression in epithelial cells
    Zhuo Lu
    Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    FEBS Lett 561:117-21. 2004
    ..The interaction between the EBS and MEF protein was further confirmed by electrophoretic mobility shift assay. Thus, our data indicate that MEF may play an important role in regulating HBD2 expression in epithelial cells...
  21. ncbi Human beta-defensin-2 in oral cancer with opportunistic Candida infection
    Jens Eduard Meyer
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    Anticancer Res 24:1025-30. 2004
    ..Malignant transformation induces alteration of hBD-2 expression and leads to a reduced hBD-2 expression and subsequentially to Candida colonization on oral SCCs...
  22. pmc High concentrations of human beta-defensin 2 in gastric juice of patients with Helicobacter pylori infection
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    World J Gastroenterol 11:4782-7. 2005
    ..Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori (H pylori). We sought to determine HBD-1 and HBD-2 concentrations in gastric juice during H pylori infection...
  23. ncbi Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1
    Kai Wehkamp
    Clinical Research Unit, Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Invest Dermatol 126:121-7. 2006
    ..We conclude that the activation of NF-kappaB (p50-p65) and AP-1 are crucial events for induction of hBD-2 in keratinocytes upon IL-1beta and PA stimulation...
  24. ncbi Involvement of phospholipase D in regulating expression of anti-microbial peptide human beta-defensin-2
    Suttichai Krisanaprakornkit
    Department of Odontology and Oral Pathology, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand
    Int Immunol 20:21-9. 2008
    ..In conclusion, these findings indicate the involvement of PLD activation in hBD-2 up-regulation in HGECs, which correlates with the state of epithelial differentiation...
  25. doi Human beta defensin 2 promotes intestinal wound healing in vitro
    Jan Michel Otte
    Department of Internal Medicine I, St Josef Hospital, Ruhr University, Bochum, Germany
    J Cell Biochem 104:2286-97. 2008
    ..Results of this in vitro study suggest, that hBD-2 expression may play a dual role in vivo, i.e. in impaired intestinal barrier function observed in patients with inflammatory bowel disease...
  26. doi Regulation of human beta-defensin-2 by Mycobacterium bovis bacillus Calmette-Guérin (BCG): involvement of PKC, JNK, and PI3K in human lung epithelial cell line (A549)
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, D F 11340 México, Mexico
    Peptides 29:1657-63. 2008
    ..These studies are the first to show that M. bovis BCG-induced HBD-2 mRNA expression in A549 cells is regulated at least in part through activation of signaling proteins of PKC, JNK and PI3K...
  27. doi Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production
    Nadege Decanis
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Pavillon de Medecine dentaire, Local 1728, 2420 Rue de la Terrasse, Universite Laval, Quebec, Que, Canada G1V 0A6
    Cytokine 45:132-40. 2009
    ..albicans growth. Overall results showed that exogenous farnesol promoted epithelial cell defense against C. albicans infection through the involvement of TLR2, IL-6, and human beta-defensin 2...
  28. pmc Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease
    Marian C Aldhous
    Gastrointestinal Unit, School of Clinical and Molecular Medicine, University of Edinburgh, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK
    PLoS ONE 4:e6285. 2009
    ..We investigated the colonic distribution of HBD2 mRNA expression, and the contributions of genetic and environmental factors on HBD2 protein production...
  29. ncbi A peptide antibiotic from human skin
    J Harder
    Nature 387:861. 1997
  30. pmc Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung
    R Bals
    Institute for Human Gene Therapy, Department of Medicine and Molecular and Cellular Engineering, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 102:874-80. 1998
    ..These data suggest the existence of a family of beta-defensin molecules on mucosal surfaces that in the aggregate contributes to normal host defense...
  31. pmc Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands
    M Mathews
    Department of Periodontics and Dows Institute for Dental Research, University of Iowa Colleges of Medicine and Dentistry, Iowa City, Iowa, USA
    Infect Immun 67:2740-5. 1999
    ..Human beta-defensins may play an important role in the innate defenses against oral microorganisms...
  32. ncbi Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6
    D Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702 1201, USA
    Science 286:525-8. 1999
    ..Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6...
  33. pmc Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells
    G Diamond
    Department of Anatomy, Cell Biology and Injury Sciences, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Infect Immun 68:113-9. 2000
    ..Together, these observations indicate that a strategy for the induction of peptide-based antimicrobial innate immunity is conserved among evolutionarily diverse organisms...
  34. ncbi Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia
    J Harder
    Department of Dermatology and Otolaryngology, University of Kiel, Kiel, Germany
    Am J Respir Cell Mol Biol 22:714-21. 2000
    ..Therefore, it might be important in lung infections caused by mucoid PA, including those seen in patients with CF...
  35. ncbi The structure of human beta-defensin-2 shows evidence of higher order oligomerization
    D M Hoover
    Macromolecular Crystallography Laboratory, Program in Structural Biology, NCI Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 275:32911-8. 2000
    ..The structural and electrostatic properties of the hBD2 octamer support an electrostatic charge-based mechanism of membrane permeabilization by beta-defensins, rather than a mechanism based on formation of bilayer-spanning pores...
  36. ncbi Regulation of human beta-defensin-2 in gingival epithelial cells: the involvement of mitogen-activated protein kinase pathways, but not the NF-kappaB transcription factor family
    Suttichai Krisanaprakornkit
    Department of Oral Biology, School of Dentistry, University of Washington, Seattle, WA 98195, USA
    J Immunol 168:316-24. 2002
    ..Studies of hBD-2 regulation provide insight into how its expression may be enhanced to control infection locally within the mucosa and thereby reduce microbial invasion into the underlying tissue...
  37. ncbi Epithelial cell-derived human beta-defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway
    Francois Niyonsaba
    Department of Biochemistry, School of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Int Immunol 14:421-6. 2002
    ..Thus, we suggest that hBD-2, which was originally believed to be involved in innate host defense, may participate in the recruitment of mast cells to inflammation foci...
  38. ncbi Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells
    Sung Kyun Moon
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Biochim Biophys Acta 1590:41-51. 2002
    ..Moreover, we demonstrate that the transcriptional activation of hBD-2 gene by IL-1 alpha is mediated through an Src-dependent Raf-MEK1/2-ERK signaling pathway...
  39. ncbi Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2
    Arya Biragyn
    Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Science 298:1025-9. 2002
    ..These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens...
  40. pmc Increased expression of antimicrobial peptides and lysozyme in colonic epithelial cells of patients with ulcerative colitis
    A Fahlgren
    Department of Immunology, Umea University, 901 85 Umea, Sweden
    Clin Exp Immunol 131:90-101. 2003
    ..The high antimicrobial activity of epithelial cells in chronic colitis may be a consequence of changes in the epithelial lining, permitting adherence of both pathogenic bacteria and commensals directly to the epithelial cell surface...
  41. ncbi Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells
    Siobhan Griffin
    Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    FEBS Lett 546:233-6. 2003
    ..An increase in HBD-2 protein expression was observed in primary NHBE cells after incubation with NE as assessed by laser scanning cytometry. In conclusion, NE up-regulates HBD-2 expression in bronchial epithelial cells...
  42. pmc Innate immune response of oral and foreskin keratinocytes: utilization of different signaling pathways by various bacterial species
    Whasun O Chung
    Department of Oral Biology, University of Washington, Seattle, Washington 98195 7132, USA
    Infect Immun 72:352-8. 2004
    ....
  43. ncbi Different expression patterns of beta-defensins in human squamous cell carcinomas
    Tomohito Yoshimoto
    Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Dental School, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Anticancer Res 23:4629-33. 2003
    ..HBD-2 may lead to the death of normal keratinocytes adjacent to the SCCs, which might, in turn, indirectly assist in the multiplication of tumor cells...
  44. pmc Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms
    Sophie Joly
    Dows Institute for Dental Research, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Microbiol 42:1024-9. 2004
    ..Finally, the significant variability between strains underlies the importance of testing multiple strains when evaluating activities of antimicrobial peptides...
  45. ncbi Up-regulation of human beta-defensin 2 by interleukin-1beta in A549 cells: involvement of PI3K, PKC, p38 MAPK, JNK, and NF-kappaB
    Byeong Churl Jang
    Department of Microbiology, Chronic Disease Research Center, Institute for Medical Science, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, Daegu 700 712, Republic of Korea
    Biochem Biophys Res Commun 320:1026-33. 2004
    ....
  46. pmc NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium
    Jan Wehkamp
    Department of Internal Medicine I, Robert Bosch Hospital, Stuttgart, Germany
    Infect Immun 72:5750-8. 2004
    ..The induction of hBD-2 may contribute to an enhanced mucosal barrier to the luminal bacteria...
  47. ncbi Correlation between beta-defensin expression and induction profiles in gingival keratinocytes
    Sophie Joly
    Dows Institute for Dental Research, University of Iowa, Iowa City, IA 52242 1001, USA
    Mol Immunol 42:1073-84. 2005
    ....
  48. pmc Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide
    Ruth MacRedmond
    Department of Respiratory Research, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    Respir Res 6:116. 2005
    ..Here we provide evidence for the critical role of Toll-like receptor 4 (TLR4) in lipopolysaccharide (LPS)-induced HBD2 expression by human A549 epithelial cells...
  49. pmc Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells
    Ashok Kumar
    Department of Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, 4717 St Antoine, Detroit, MI 48201, USA
    Microbes Infect 8:380-9. 2006
    ..Thus, the epithelium might play a role in innate defense against bacterial infection by directly killing bacteria in the cornea...
  50. ncbi NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2
    Eske Voss
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
    J Biol Chem 281:2005-11. 2006
    ..Together, these data suggest that NOD2 serves as an intracellular pattern recognition receptor to enhance host defense by inducing the production of antimicrobial peptides such as hBD-2...
  51. pmc Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells
    Sung Kyun Moon
    The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
    BMC Infect Dis 6:12. 2006
    ..influenzae (NTHi) and that interleukin 1 alpha (IL-1 alpha) up-regulates the transcription of beta-defensin 2 (DEFB4 according to new nomenclature of the Human Genome Organization) in human middle ear epithelial cells via a Src-..
  52. pmc A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon
    Klaus Fellermann
    Department of Internal Medicine I, Robert Bosch Hospital, 70376 Stuttgart, Germany
    Am J Hum Genet 79:439-48. 2006
    ..033). In conclusion, a lower HBD-2 gene copy number in the beta-defensin locus predisposes to colonic CD, most likely through diminished beta-defensin expression...
  53. ncbi Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines
    Akiko Uehara
    Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Mol Immunol 44:3100-11. 2007
    ..These findings indicate that TLR and NOD in various epithelial cells are functional receptors that induce anti-bacterial responses in general without being accompanied by inflammatory responses...
  54. pmc Psoriasis is associated with increased beta-defensin genomic copy number
    Edward J Hollox
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Nat Genet 40:23-5. 2008
    ..Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis...
  55. pmc Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium
    Cheng Yuan Kao
    Center for Comparative Respiratory Biology and Medicine, University of California Davis, 451 Health Science Drive, Davis, CA 95616, USA
    J Biol Chem 283:15309-18. 2008
    ..This is the first demonstration of the involvement of two proximal NF-kappaB sites and IkappaB-zeta in the regulation of hBD-2 by IL-17A, two important genes responsible for host defense...
  56. doi Leptin enhances human beta-defensin-2 production in human keratinocytes
    Naoko Kanda
    Department of Dermatology, Teikyo University School of Medicine, 11 1 Kaga 2 Itabashi Ku, Tokyo 173 8605, Japan
    Endocrinology 149:5189-98. 2008
    ..Leptin may promote cutaneous antimicrobial defense, inflammation, and wound repair via hBD-2...
  57. pmc CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells
    Rebecca A Vongsa
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 284:10034-45. 2009
    ..These findings expand the mechanistic role for chemokines and HBD2 in mucosal inflammation to include immunocyte trafficking and killing of microbes with the concomitant activation of restitutive migration and barrier repair...
  58. doi The antimicrobial peptide HBD-2 and the Toll-like receptors-2 and -4 are induced in synovial membranes in case of septic arthritis
    D Varoga
    Department of Orthopaedic Trauma Surgery, UKSH Campus Kiel, Kiel, Germany
    Virchows Arch 454:685-94. 2009
    ..The induction of anti-inflammatory pathways in infected synoviocytes suggests involvement in intra-articular defense mechanisms...
  59. doi Loss of human beta-defensin 1, 2, and 3 expression in oral squamous cell carcinoma
    S Joly
    Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA, USA
    Oral Microbiol Immunol 24:353-60. 2009
    ..The purpose of this study was to evaluate the regulation of HBD-1 (also published as DEFB1), HBD-2 (DEFB4) and HBD-3 (DEFB103A) (http://www.genenames.org/index...
  60. pmc Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, California 92161, USA
    J Invest Dermatol 130:985-94. 2010
    ..acnes and enhance the skin's innate antibacterial defense by inducing the expression of hBD-2 in sebocytes as well...
  61. pmc Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells
    Johann Röhrl
    Institute of Immunology, University of Regensburg, Regensburg D 93042, Germany
    J Biol Chem 285:7028-34. 2010
    ..Thus, the beta-defensin fusion proteins used in this study retained their biological activity and are a feasible tool to identify and analyze specific beta-defensin receptor interactions...
  62. doi Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease
    Wim Janssens
    Department of Human Genetics, Katholieke Universiteit Leuven, Gasthuisberg O and N1 602, Herestraat 49, B 3000, Leuven, Belgium
    Am J Respir Crit Care Med 182:163-9. 2010
    ..Controversy still exists on whether the beta-defensins genes determine susceptibility for chronic obstructive pulmonary disease (COPD)...
  63. pmc Differential and coordinated expression of defensins and cytokines by gingival epithelial cells and dendritic cells in response to oral bacteria
    Lei Yin
    Department of Oral Biology, School of Dentistry, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, Box 357132, USA
    BMC Immunol 11:37. 2010
    ..The present study was conducted to investigate whether their responses are coordinated and are bacteria-specific in the oral cavity...
  64. doi Human beta-defensin-1, -2, and -3 exhibit opposite effects on oral squamous cell carcinoma cell proliferation
    Jochen Winter
    Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
    Cancer Invest 29:196-201. 2011
    ..HBD-3 stimulation enhanced hBD-1 expression. HBDs profoundly impact on OSCC proliferation and hBD expression in vitro. Therefore, hBD-1 might function as a tumor suppressor gene in OSCCs, while hBD-2 and -3 might be protooncogenes...
  65. ncbi Human beta-defensin-2 controls cell cycle in malignant epithelial cells: in vitro study
    E Zhuravel
    R E Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine
    Exp Oncol 33:114-20. 2011
    ..In the present research we analyze the mechanism of human beta-defensin-2 (hBD-2) influence on cultured malignant epithelial cell growth...
  66. doi Reduced tonsillar expression of human β-defensin 1, 2 and 3 in allergic rhinitis
    Jesper Bogefors
    Laboratory of Clinical and Experimental Allergy Research, Department of Otorhinolaryngology, Skane University Hospital, Lund University, Malmo, Sweden
    FEMS Immunol Med Microbiol 65:431-8. 2012
    ..Together with the down-regulation of HBDs in epithelial cells in the presence of allergic mediators suggest that AR patients have an impaired antimicrobial defense that might make them more susceptible to respiratory tract infections...
  67. doi Human β-defensin 2 expression in ELBW infants with severe necrotizing enterocolitis
    Andreas C W Jenke
    Department of Neonatology, HELIOS Children s Hospital, Witten Herdecke University, Wuppertal, Germany
    Pediatr Res 72:513-20. 2012
    ..The aim of this study was to analyze whether the mucosal innate immune response of extremely-low-birth-weight (ELBW) infants might play a role in the development of necrotizing enterocolitis (NEC)...
  68. doi Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer
    Shuhei Abe
    Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Hum Genet 58:250-3. 2013
    The aim of this study was to investigate association between copy number variation of the defensin beta 4 gene (DEFB4) and susceptibility to cervical cancer in a population at high risk of persistent oncogenic human papillomavirus (HPV) ..
  69. ncbi The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus
    David J Schibli
    Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
    J Biol Chem 277:8279-89. 2002
    ....
  70. pmc Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation
    Timothy D Starner
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Infect Immun 70:5287-9. 2002
    ..In contrast, NTHI was more susceptible to HBD-3 and showed no changes in sensitivity as a result of lipooligosaccharide mutations in oligosaccharide and lipid A biosynthesis genes...
  71. ncbi Human beta-defensin-2 induction in Helicobacter pylori-infected gastric mucosal tissues: antimicrobial effect of overexpression
    N Uehara
    Division of Laboratory Diagnosis, Sapporo Medical University School of Medicine, South 1, West 16, Chuo ko, Sapporo 060 8543, Japan
    J Med Microbiol 52:41-5. 2003
    ..pylori completely. The results suggest that hBD-2 may be involved in the pathophysiology of H. pylori-induced gastritis...
  72. ncbi Transcriptional regulation of beta-defensin-2 by lipopolysaccharide in cultured human cervical carcinoma (HeLa) cells
    Junji Mineshiba
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    FEMS Immunol Med Microbiol 45:37-44. 2005
    ..Our results suggest that the two NF-(kappa)B binding sites contribute to LPS-mediated hBD-2 transcription while the NF-IL6 binding site represses LPS-independent hBD-2 transcription in the HeLa cells...
  73. doi Expression of human beta-defensin-2 in intratumoral vascular endothelium and in endothelial cells induced by transforming growth factor beta
    Hameem I Kawsar
    Department of Biological Sciences, Case Western Reserve University School of Dental Medicine, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Peptides 31:195-201. 2010
    ....
  74. pmc Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells
    Alison M McDermott
    College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
    Invest Ophthalmol Vis Sci 44:1859-65. 2003
    ....
  75. ncbi Differential gene induction of human beta-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid
    Jurgen Harder
    Clinical Research Unit, Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstrasse7, D 24105 Kiel, Germany
    J Invest Dermatol 123:522-9. 2004
    ..We conclude that RA is a potent inhibitor of beta-defensin induction in keratinocytes and might downregulate the inducible innate chemical defense system of human skin...
  76. pmc Protease-activated receptor 2 mediates human beta-defensin 2 and CC chemokine ligand 20 mRNA expression in response to proteases secreted by Porphyromonas gingivalis
    Henrik Dommisch
    Department of Oral Biology, School of Dentistry, University of Washington, Box 357132, Seattle, WA 98195 7132, USA
    Infect Immun 75:4326-33. 2007
    ..GECs use PARs to recognize P. gingivalis and mediate cell responses involved in innate immunity...
  77. ncbi Localized antimicrobial peptide expression in human gingiva
    B A Dale
    Department of Oral Biology, School of Dentistry, University of Washington, Seattle 98195 7132, USA
    J Periodontal Res 36:285-94. 2001
    ..These findings show that defensins and other antimicrobial peptides are localized in specific sites in the gingiva, are synthesized in different cell types, and are likely to serve different roles in various regions of the periodontium...
  78. pmc Increased concentrations of human beta-defensins in plasma and bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis
    T Hiratsuka
    Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Thorax 58:425-30. 2003
    ..The aim of this study was to elucidate the role of these antimicrobial peptides in this disease...
  79. ncbi Ultraviolet A1-induced downregulation of human beta-defensins and interleukin-6 and interleukin-8 correlates with clinical improvement in localized scleroderma
    A Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    Br J Dermatol 155:600-7. 2006
    ..Ultraviolet (UV) A1 phototherapy, the most recent advance in the treatment of LS, targets T-cell dermal inflammatory infiltrates via induction of various cytokines and soluble factors besides well-known effects on collagen metabolism...
  80. ncbi Human defensins
    Josef Johann Schneider
    Klinik und Poliklinik fur Dermatologie und Allergologie, Ludwig Maximilians Universitat Munchen, Frauenlobstrasse 9 11, 80337 Munich, Germany
    J Mol Med (Berl) 83:587-95. 2005
    ..Its bactericidal activity against P. aeruginosa is stronger than that of the other known beta-defensins. Here we present an overview of human antimicrobial peptides with some emphasis on their antifungal properties...
  81. ncbi A newly discovered function of palatine tonsils in immune defence: the expression of defensins
    J B Weise
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Germany
    Otolaryngol Pol 56:409-13. 2002
    ..Thus, palatine tonsils have a potentially influence in the growth and control of the physiological mouth bacteria by their bactericidal activity...
  82. doi Antibacterial and lipopolysaccharide (LPS)-neutralising activity of human cationic antimicrobial peptides against periodontopathogens
    Sung Hoon Lee
    Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul, Republic of Korea
    Int J Antimicrob Agents 35:138-45. 2010
    ..These results suggest that AMPs may be considered as preventive and therapeutic agents against mixed bacterial infections such as periodontitis by eliminating the pathogens themselves as well as reducing the activity of LPS...
  83. ncbi Defence molecules in intestinal innate immunity against bacterial infections
    Lars Eckmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Curr Opin Gastroenterol 21:147-51. 2005
    ..Antimicrobial proteins are key effector molecules of innate immunity. The review discusses recent progress in understanding the function of these host defence molecules in intestinal physiology...
  84. ncbi Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins
    Axel Schulz
    IPF PharmaCeuticals GmbH, Feodor Lynen Strasse 31, D 30625 Hannover, Germany
    Biopolymers 80:34-49. 2005
    ..This might be due to the low positive net charge, which is significantly higher for hBD-2, hBD-3, and hBD-28...
  85. doi Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells
    Francois Niyonsaba
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 184:3526-34. 2010
    ....
  86. ncbi Expression of human beta-defensins HBD-1, HBD-2, and HBD-3 in cultured keratinocytes and skin substitutes
    Dorothy M Supp
    Research Department, Shriners Hospitals for Children, Cincinnati Burns Hospital, 3229 Burnet Avenue, Cincinnati, OH 45229, USA
    Burns 30:643-8. 2004
    ..We conclude that beta-defensins can potentially contribute to innate immunity in CSS, but their levels may be too low to prevent contamination after grafting...
  87. pmc Pattern of mRNA expression of beta-defensins in basal cell carcinoma
    T Gambichler
    Department of Dermatology and Allergology, Ruhr University Bochum Gudrunstr, 56, D 44791 Bochum, Germany
    BMC Cancer 6:163. 2006
    ..The present work was aimed on the study of hBD gene expression in basal cell carcinoma (BCC) which is the most common cancer in humans...
  88. ncbi Significance of human beta-defensins in the epithelial lining fluid of patients with chronic lower respiratory tract infections
    S Yanagi
    Third Department of Internal Medicine, Miyazaki University School of Medicine, Miyazaki, Japan
    Clin Microbiol Infect 13:63-9. 2007
    ..The findings indicate that hBDs, especially hBD-2 and hBD-4, are pathophysiologically important in infections caused by mucoid strains of P. aeruginosa...
  89. doi Treponema denticola suppresses expression of human beta-defensin-2 in gingival epithelial cells through inhibition of TNFalpha production and TLR2 activation
    Ji Eun Shin
    Department of Oromaxillofacial Infection and Immunity, Brain Korea 21 CLS, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, 110 749, Korea
    Mol Cells 29:407-12. 2010
    ..Collectively, T. denticola suppresses the expression of HBD-2 in gingival epithelial cells by inhibiting the TLR2 axis and TNFalpha production, which may contribute to the pathogenesis of periodontitis by T. denticola...
  90. ncbi Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators
    S Claeys
    Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Belgium
    Clin Exp Allergy 35:467-72. 2005
    ..Innate defence markers and inflammatory mediators in NP from patients with CF were compared with non-cystic fibrosis nasal polyps (non-CF-NP) to determine a possible different immunological background in macroscopically similar tissue...
  91. pmc Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption
    Slavena Vylkova
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Antimicrob Agents Chemother 51:154-61. 2007
    ....
  92. pmc Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms
    Ludmila Alekseeva
    UMR 956, INRA, AFSSA, ENVA, Maisons Alfort Cedex, France
    BMC Microbiol 9:33. 2009
    ..The role of the airway epithelium involves a complex interaction with the inhaled pathogen. Antimicrobial peptides with direct antifungal and chemotactic activities may boost antifungal immune response...
  93. ncbi Differential gene expression of human beta-defensins (hBD-1, -2, -3) in inflammatory gingival diseases
    H Dommisch
    Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany
    Oral Microbiol Immunol 20:186-90. 2005
    ..016); however, hBD-2 expression was comparable to hBD-3. In conclusion, the results of the present study showed a differential expression of human beta-defensins (hBD-1, -2, -3) in tissues with inflammatory gingival disease...
  94. doi Concentrations of alpha- and beta-defensins in plasma of patients with inflammatory bowel disease
    N Yamaguchi
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Inflamm Res 58:192-7. 2009
    ..Impaired production/release of defensins, representative endogenous antimicrobial peptides, is associated with the pathogenesis of inflammatory bowel disease (IBD)...
  95. ncbi Expression of beta-defensins in human middle ear cholesteatoma
    Keehyun Park
    Department of Otolaryngology, Ajou University School of Medicine, Suwon, South Korea
    Acta Otolaryngol 123:236-40. 2003
    ..To establish the eventual presence of human beta-defensins (hBD) in middle ea r cholesteatoma and paired retroauricular skin samples obtained during surgical treatment...
  96. ncbi Intracellular calcium in signaling human beta-defensin-2 expression in oral epithelial cells
    S Krisanaprakornkit
    Department of Odontology Oral Pathology, Faculty of Dentistry, Chiang Mai University, Thailand
    J Dent Res 82:877-82. 2003
    ....
  97. pmc Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7)
    Carole L Wilson
    Department of Pathology and Center for Lung Biology, University of Washington, Seattle, Washington 98104, USA
    J Biol Chem 284:8301-11. 2009
    ....
  98. ncbi Discovery of new human beta-defensins using a genomics-based approach
    H P Jia
    Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Gene 263:211-8. 2001
    ..The discovery of these novel beta-defensin genes may allow further understanding of the role of defensins in host immunity at mucosal surfaces...
  99. pmc Expression of human beta-defensins in conjunctival epithelium: relevance to dry eye disease
    Srihari Narayanan
    College of Optometry, University of Houston, Houston, Texas 77204, USA
    Invest Ophthalmol Vis Sci 44:3795-801. 2003
    ....
  100. ncbi Human beta-defensin 2 is up-regulated during re-epithelialization of the cornea
    A M McDermott
    College of Optometry, University of Houston, Houston, TX 77044, USA
    Curr Eye Res 22:64-7. 2001
    ..Breach of the epithelium leaves the cornea vulnerable to infection so we sought to determine if there is an increase in defensin expression after injury...
  101. ncbi [Defensins as a mechanism of host defense and innate immunity]
    T Tomita
    Department of Geriatric Medicine, Faculty of Medicine, University of Tokyo
    Nihon Ronen Igakkai Zasshi 38:440-3. 2001
    ..Defensins may play a key role in the mechanism of host defense and innate immunity. These defensins, including hBD-2, might provide a new therapeutic approach to infectious diseases...

Research Grants27

  1. GINGIVAL EPITHELIAL CELL ANTIMICROBIAL PEPTIDES
    Aaron Weinberg; Fiscal Year: 2002
    ..abstract_text> ..
  2. C.ALBICANS REGULATION BETA-DEFENSINS IN ORAL EPITHELIA
    Aaron Weinberg; Fiscal Year: 2002
    ..The PI states that this research direction may be significant in leading to future studies with potential application to oral disorders, therapeutic use, and technology development. ..
  3. FUNCTION OF B-DEFENSINS IN COMMON ORAL INFECTIONS
    Janet Guthmiller; Fiscal Year: 2002
    ....
  4. MODULATION OF BETA-DEFENSINS BY MATRILYSIN
    Carole Wilson; Fiscal Year: 2001
    ..The proposed experiments should provide insight into the role of MMP-7 in mucosal epithelium and how this metalloenzyme contributes to mechanisms of host defense. ..
  5. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..The long-range goal of our research is to understand the role of -defensins in the innate immune defense against viruses so that novel therapies can be developed from our findings. ..
  6. HIGH-DOSE VITAMIN D AND ANTIMICROBIAL PEPTIDE EXPRESSION IN LUNG FAILURE
    Thomas R Ziegler; Fiscal Year: 2012
    ....
  7. Roles of IL-17-induced gene expression in airway epithelial host defense
    Reen Wu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): During the last grant period, our lab has uncovered the stimulation of DEFB4 (previously called 2-defensin 2) or mBD3/4 (mouse equivalent to DEFB4), CCL20, and IL-19 in human and mouse airway ..
  8. Sharof M Tugizov; Fiscal Year: 2016
    ....
  9. Innate Immunity in Otitis Media Pathogenesis
    David J Lim; Fiscal Year: 2013
    ..Of the AIIMs tested to date, 2-defensin 2 (DEFB4) is the most effective antimicrobial molecule against OM pathogens...
  10. IMMUNITY TO STDS IN THE HUMAN MALE GENITAL TRACT
    Deborah Anderson; Fiscal Year: 2004
    ..abstract_text> ..
  11. Biofilm Formation And P. aeruginosa infection of the eye
    Michael Zegans; Fiscal Year: 2006
    ..abstract_text> ..
  12. Corneal hBD-2 Regulation by Pseudomonas Aeruginosa
    Inna Maltseva; Fiscal Year: 2007
    ..Furthermore, the knowledge provided by the investigation could suggest pharmacological intervention during corneal bacterial infection. ..
  13. Helper Phage Mobilization of Staphylococcal Enterotoxin Genes
    GAIL CHRISTIE; Fiscal Year: 2007
    ..b>SaP1 transducing particles resemble those of the helper phage but have heads about 1/3 the volume of the plaque-forming ..
  14. NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS
    Tomas Ganz; Fiscal Year: 2001
    ....
  15. Antimicrobial Gene Therapy
    George Huang; Fiscal Year: 2003
    ....
  16. Defensin Gene Cluster Variation & Candida Carriage
    RICHARD JUREVIC; Fiscal Year: 2009
    The goal of this application is to investigate the beta-defensin gene DEFB-1 and the beta-defensin gene cluster, DEFB4, DEFB103 and DEFB104, and the effect of genetic variations on susceptibility of fungal infection in immuno-..
  17. Regulation of Human Beta-Defensins in Epithelia
    WHASUN CHUNG; Fiscal Year: 2006
    ..Identifying specific routes pathogens take in stimulating beta-defensins may open the way for development of new therapeutic agents that stimulate the innate immune response. ..
  18. Epithelial Innate Immune Response to Oral Bacteria
    WHASUN CHUNG; Fiscal Year: 2008
    ..This work will lay the groundwork for identifying new therapeutic targets to prevent and treat periodontal diseases. [unreadable] [unreadable]..
  19. Regulation of Beta-Defensin Expression in Oral Epithelia
    WHASUN CHUNG; Fiscal Year: 2009
    ..These studies will lead to new insights on the role of innate immunity and new potential targets for therapeutic drug development for oral infections. ..
  20. Protease-activated receptor signaling in oral innate im*
    BEVERLY DALE CRUNK; Fiscal Year: 2005
    ..abstract_text> ..
  21. DENTIST SCIENTIST AWARD--INSTITUTIONAL
    BEVERLY DALE CRUNK; Fiscal Year: 2004
    ..Ultimately, understanding the body's capability of modulating pain sensitivity may lead to improved methods in the pharmacological management of pain. ..
  22. Structure based drug discovery
    STEPHEN BURLEY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  23. Beta-defensins and pulmonary host defense
    Timothy Starner; Fiscal Year: 2006
    ..This environment will maximize the potential for the principal investigator to establish himself in a basic science career as an academic independent investigator. ..
  24. Host-Pathogen Interactions in the Mammalian Airway
    Gill Diamond; Fiscal Year: 2006
    ..This would include strategies to modulate the endogenous antimicrobial peptide expression to prevent serious bacterial infections. ..
  25. Structural Genomics
    STEPHEN BURLEY; Fiscal Year: 2004
    ..Finally, this meeting is being held in conjunction with the 2004 Keystone Structural Biology Meeting, and features three joint sessions (including the Keynote). ..
  26. X-RAY STRUCTURES OF EUKARYOTIC TRANSLATION FACTORS
    STEPHEN BURLEY; Fiscal Year: 2003
    ..Specific Aim 6. Determine X-ray structures of PABP recognizing poly (A) RNA, and various binary and ternary complexes with a PABP-interacting protein and eIF4G. ..
  27. Bacteria-host cell interactions in periodontal disease
    Gill Diamond; Fiscal Year: 2005
    ..The result from this study will allow us to develop novel strategies to prevent attachment and colonization of disease-causing bacteria. ..