HBA1

Summary

Gene Symbol: HBA1
Description: hemoglobin subunit alpha 1
Alias: HBA-T3, HBH, hemoglobin subunit alpha, alpha one globin, alpha-2 globin chain, delta globin, hemoglobin alpha 1 globin chain, hemoglobin, alpha 1
Species: human

Top Publications

  1. ncbi Structure of human oxyhaemoglobin at 2.1 A resolution
    B Shaanan
    J Mol Biol 171:31-59. 1983
  2. pmc Heterogeneous behavior of lipids according to HbA1c levels undermines the plausibility of metabolic syndrome in type 1 diabetes: data from a nationwide multicenter survey
    Fernando M A Giuffrida
    Centro de Endocrinologia do Estado da Bahia, Salvador, Brazil
    Cardiovasc Diabetol 11:156. 2012
  3. ncbi Homology and concerted evolution at the alpha 1 and alpha 2 loci of human alpha-globin
    S A Liebhaber
    Nature 290:26-9. 1981
  4. doi Use of confirmatory factor analysis for the identification of new components of the metabolic syndrome: the role of plasminogen activator inhibitor-1 and Haemoglobin A1c
    M Boronat
    Section of Endocrinology and Nutrition, Hospital Universitario Insular, Avda Maritima del Sur s n, Las Palmas de Gran Canaria, Spain
    Nutr Metab Cardiovasc Dis 19:271-6. 2009
  5. doi GLP-1 receptor agonists and HBA1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials
    K Esposito
    Department of Cario Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
    Curr Med Res Opin 27:1519-28. 2011
  6. doi PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin
    Tao Hu
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biochemistry 48:608-16. 2009
  7. ncbi A third quaternary structure of human hemoglobin A at 1.7-A resolution
    M M Silva
    Department of Biochemistry, University of Iowa, Iowa City 52242
    J Biol Chem 267:17248-56. 1992
  8. ncbi Hb Hekinan observed in three Chinese from Macau; identification of the GAG----GAT mutation in the alpha 1-globin gene
    W Zhao
    Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912 2100
    Hemoglobin 14:627-35. 1990
  9. pmc Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c
    Robert M Cohen
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Cincinnati College of Medicine, Vontz Center for Molecular Studies, 3125 Eden Avenue, Cincinnati, OH 45267 0547, USA
    Blood 112:4284-91. 2008
  10. pmc Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Genet 4:e1000312. 2008

Research Grants

  1. Seyedtaghi Takyar; Fiscal Year: 2015
  2. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2012
  3. Interaction of thrombospondin-1 with alpha9beta1 integrin in glioma angiogenesis
    Cezary Marcinkiewicz; Fiscal Year: 2012
  4. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
  5. JAMES MICHAEL DUNLEAVEY; Fiscal Year: 2015
  6. Christopher D Kontos; Fiscal Year: 2014
  7. Peter J Newman; Fiscal Year: 2016
  8. Fatal Attration: T lymphocytes and liver endothelial cell during sepsis.
    NOELLE A HUTCHINS; Fiscal Year: 2012
  9. The role of endothelial Notch signaling in murine lung branching morphogenesis
    Eric Jelin; Fiscal Year: 2010
  10. William A Muller; Fiscal Year: 2016

Detail Information

Publications713 found, 100 shown here

  1. ncbi Structure of human oxyhaemoglobin at 2.1 A resolution
    B Shaanan
    J Mol Biol 171:31-59. 1983
    ....
  2. pmc Heterogeneous behavior of lipids according to HbA1c levels undermines the plausibility of metabolic syndrome in type 1 diabetes: data from a nationwide multicenter survey
    Fernando M A Giuffrida
    Centro de Endocrinologia do Estado da Bahia, Salvador, Brazil
    Cardiovasc Diabetol 11:156. 2012
    ....
  3. ncbi Homology and concerted evolution at the alpha 1 and alpha 2 loci of human alpha-globin
    S A Liebhaber
    Nature 290:26-9. 1981
    ....
  4. doi Use of confirmatory factor analysis for the identification of new components of the metabolic syndrome: the role of plasminogen activator inhibitor-1 and Haemoglobin A1c
    M Boronat
    Section of Endocrinology and Nutrition, Hospital Universitario Insular, Avda Maritima del Sur s n, Las Palmas de Gran Canaria, Spain
    Nutr Metab Cardiovasc Dis 19:271-6. 2009
    ..This study was aimed to identify additional components of metabolic syndrome from a set of cardiovascular risk markers...
  5. doi GLP-1 receptor agonists and HBA1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials
    K Esposito
    Department of Cario Thoracic and Respiratory Sciences, Second University of Naples, Naples, Italy
    Curr Med Res Opin 27:1519-28. 2011
    ..Glucagon-like peptide-1 (GLP-1) receptor agonists are available for the treatment of type 2 diabetes. We assessed the efficacy of exenatide and liraglutide to reach the HbA(1c) target of <7% in people with type 2 diabetes...
  6. doi PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin
    Tao Hu
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Biochemistry 48:608-16. 2009
    ..In contrast, PEGylation of Hb at Val-1(beta) gives rise to less pronounced structural alteration and different functional change...
  7. ncbi A third quaternary structure of human hemoglobin A at 1.7-A resolution
    M M Silva
    Department of Biochemistry, University of Iowa, Iowa City 52242
    J Biol Chem 267:17248-56. 1992
    ....
  8. ncbi Hb Hekinan observed in three Chinese from Macau; identification of the GAG----GAT mutation in the alpha 1-globin gene
    W Zhao
    Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912 2100
    Hemoglobin 14:627-35. 1990
    ..Dot-blot analysis of amplified DNA with 32P-labeled probes located the mutation in codon 27 of the minor alpha 1-globin gene; the change involved a GAG (coding for glutamic acid) to GAT (coding for aspartic acid) mutation...
  9. pmc Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c
    Robert M Cohen
    Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, University of Cincinnati College of Medicine, Vontz Center for Molecular Studies, 3125 Eden Avenue, Cincinnati, OH 45267 0547, USA
    Blood 112:4284-91. 2008
    ..HbA1c synthesis was linear and correlated with mean whole blood HbA1c (R(2) = 0.91). The observed variation in RBC survival was large enough to cause clinically important differences in HbA1c for a given mean blood glucose...
  10. pmc Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study
    Guillaume Pare
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Genet 4:e1000312. 2008
    ..This observed genetic association between glycated hemoglobin levels and HK1 polymorphisms paves the way for further studies of the role of HK1 in hemoglobin glycation, glucose metabolism, and diabetes...
  11. pmc Glycosylated hemoglobin (HbA1c) levels and clinical outcomes in diabetic patients following coronary artery stenting
    Seyed Ebrahim Kassaian
    Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
    Cardiovasc Diabetol 11:82. 2012
    ..The aim of the present study was to investigate whether a pre- and post-procedural glycaemic control in diabetic patients was related to major advance cardiovascular events (MACE) during follow up...
  12. pmc High HbA1c levels correlate with reduced plaque regression during statin treatment in patients with stable coronary artery disease: results of the coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese
    Hiroyuki Daida
    Department of Cardiology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Cardiovasc Diabetol 11:87. 2012
    ..5 mg once daily, up-titrated to a maximum of 20 mg/day to achieve LDL cholesterol <80 mg/dl)...
  13. ncbi A review of the molecular genetics of the human alpha-globin gene cluster
    D R Higgs
    Nuffield Department of Clinical Medicine, John Radcliff Hospital, Oxford, England
    Blood 73:1081-104. 1989
  14. pmc Glycated hemoglobin and associated risk factors in older adults
    Raul A Martins
    Faculty of Sport Sciences and Physical Education, University of Coimbra, Estádio Universitário, Pavilhão 3, 3040 156 Coimbra, Portugal
    Cardiovasc Diabetol 11:13. 2012
    ..Age is associated with several risk factors as increased body fat and abdominal fat, deterioration of the lipid profile, diabetes, raising in inflammatory activity, or decreased functional fitness...
  15. ncbi Effects of nitrendipine on blood pressure, renin-angiotensin-system and atrial natriuretic peptide in hypertensive type I diabetic patients
    H Lehnert
    III. Medizinische Klinik, , Germany
    Horm Metab Res 25:24-8. 1993
    ..natriuretic peptide (ANP), plasma renin activity (PRA) and active renin, aldosterone, glycosylated hemoglobin (HbA1) and fructosamines were determined at the beginning and the end of the study...
  16. ncbi Increased plasma levels of endothelin in diabetic patients with hypertension
    T Haak
    Department of Endocrinology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Am J Hypertens 5:161-6. 1992
    ..Glycosylated hemoglobin (HbA1) concentrations above 10% of total hemoglobin were measured in 62% of the patients...
  17. ncbi [Superoxide anion (O2-) production by polymorphonuclear leukocytes in insulin dependent diabetes mellitus (IDDM)]
    H Nakahata
    Third Department of Internal Medicine, Hirosaki University School of Medicine
    Kansenshogaku Zasshi 65:521-6. 1991
    ..001 at 10 and 30 min.). O2- production at 10 and 30 min. possessed a negative correlation with Hba1 and A1c value (HbA1: p less than 0.01 at 10 min. p less than 0.05 at 30 min., HbA1c: p less than 0...
  18. ncbi [Value of glucose, glycosylated hemoglobin and fructosamine in blood of patients with ischemic cerebral infarction without diabetes during the early stage of the disease]
    B Chmielewska
    Katedra i Klinika Neurologii Akademii Medycznej w Lublinie
    Ann Univ Mariae Curie Sklodowska Med 51:61-8. 1996
    Fasting blood glucose level, glycosylated haemoglobin (HBA1) and fructosamine (FA) were measured in 37 non-diabetic patients with a recent (48 h) brain infarction of the carotid territory...
  19. ncbi [The concentration of glucose, glycosylated hemoglobin and fructosamine in blood of patients with cerebral hemorrhage in the acute stage of the disease]
    B Chmielewska
    Katedra i Klinika Neurologii, Akademia Medyczna w Lublinie
    Ann Univ Mariae Curie Sklodowska Med 50:123-30. 1995
    The level of glucose, fructosamine (FA), glucosylated hemoglobin (HbA1) was determined for 21 patients with cerebral haemorrhage at an early stage of their illness...
  20. ncbi Patients' participation in medical care: effects on blood sugar control and quality of life in diabetes
    S Greenfield
    Department of Medicine, University of California, Los Angeles
    J Gen Intern Med 3:448-57. 1988
    ..The mean pre-intervention glycosylated hemoglobin (HbA1) values were 10.6 +/- 2.1% for 33 experimental patients and 10.3 +/- 2.0% for 26 controls...
  21. ncbi High dose supplementation of RRR-alpha-tocopherol decreases cellular hemostasis but accelerates plasmatic coagulation in type 2 diabetes mellitus
    P Ferber
    German Diabetes Research Institute at the Heinrich-Heine University,
    Horm Metab Res 31:665-71. 1999
    ..0; HbA1 at baseline 10.25+/-1.7). RESULTS: Average vitamin E levels increased 2.65-fold accompanied by a 1...
  22. ncbi Proteomic profiling of human retinal and choroidal endothelial cells reveals molecular heterogeneity related to tissue of origin
    David O Zamora
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Mol Vis 13:2058-65. 2007
    ..Because the proteome ultimately determines the behavior of any given cell, however, it is critical to determine whether molecular differences exist at the level of protein expression...
  23. ncbi Glycemic control and alveolar bone loss progression in type 2 diabetes
    G W Taylor
    School of Dentistry, University of Michigan, Ann Arbor, USA
    Ann Periodontol 3:30-9. 1998
    ..The PC group had glycosylated hemoglobin (HbA1) > or = 9%; the BC group had HbA1 < 9%...
  24. ncbi Hypoglycemia and the decision to drive a motor vehicle by persons with diabetes
    W L Clarke
    Department of Pediatrics, The University of Virginia Health Sciences Center, Charlottesville 22908, USA
    JAMA 282:750-4. 1999
    ..6 and 3.6 mmol/L (47-65 mg/dL). However, to our knowledge, no data exist examining subjects' decisions to drive at various BG levels during their daily routine...
  25. ncbi The effects of glibenclamide on glucose homeostasis and lipoprotein metabolism in poorly controlled type 2 diabetes
    C Baynes
    Unit of Metabolic Medicine, St. Mary's Hospital, London, United Kingdom
    Horm Metab Res 25:96-101. 1993
    ..in almost all the measured parameters of glucose homeostasis (plasma glucose, glycosylated haemoglobin (HbA1), hepatic glucose production and insulin-mediated glucose disposal) neither fasting serum triglycerides nor HDL ..
  26. doi Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year period
    Armita Bahrami
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 34:1504-13. 2010
    ..We conclude that true FS is exceedingly rare, accounting for <1% of approximately 10,000 adult soft tissue sarcomas seen at our institution during this time period, and should be diagnosed with great caution...
  27. ncbi Antibodies to GAD and glycemic control in recent-onset IDDM
    R D Hoeldtke
    Department of Medicine, West Virginia University, Morgantown 26506 9159, USA
    Diabetes Care 20:1900-3. 1997
    ..To analyze the effect of antibodies to glutamic acid decarboxylase (GAD65Ab) and islet cells (ICA512Ab) on glycemic control early in IDDM...
  28. ncbi Structure and expression of the human theta 1 globin gene
    S L Hsu
    Institute of Molecular Biology, Academia Sinica, Taiwan, Republic of China
    Nature 331:94-6. 1988
    ....
  29. pmc Suppression of human colon tumor growth by adenoviral vector-mediated NK4 expression in an athymic mouse model
    Jian Zheng Jie
    State Key Laboratory of Molecular Virology and Genetic Engineering, 9 Dong Dan San Tiao, Dong Cheng Qu, Beijing 100730, China
    World J Gastroenterol 13:1938-46. 2007
    ....
  30. ncbi Progression of diabetic retinopathy and changes in serum insulin-like growth factor I (IGF I) during continuous subcutaneous insulin infusion (CSII)
    S L Hyer
    Department of Medicine, Royal Postgraduate Medical School, St. Mary's Hospital, London, United Kingdom
    Horm Metab Res 21:18-22. 1989
    ..8 +/- 4.7 yrs, serum IGF I concentration, HbA1 and retinopathy score were estimated prospectively over twelve months following the institution of CSII therapy...
  31. ncbi the "Ulm Zucker Uhr System" and its consequences
    E F Pfeiffer
    , , Germany
    Horm Metab Res 26:510-4. 1994
    ..Likewise, over 48 hours, the hyperglycemic periods are transmitted and recorded which are not measured and reflected by the HbA1 and HbA1c conventional measurements.(ABSTRACT TRUNCATED AT 250 WORDS)
  32. doi Thalidomide attenuates tumor growth and preserves fast-twitch skeletal muscle fibers in cholangiocarcinoma rats
    Keng Hao Liu
    Department of Surgery, Xiamen Chang Gung and Hospital Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Surgery 143:375-83. 2008
    ..Cancer cachexia is associated with decreased survival and poor quality of life. Herein, we present a rat model of cholangiocarcinoma and demonstrate that thalidomide attenuates tumor growth and improves cachexia...
  33. ncbi Sinus histiocytosis with massive lymphadenopathy and Langerhans cell histiocytosis express the cellular adhesion molecule CD31
    Stephen P Slone
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Arch Pathol Lab Med 127:341-4. 2003
    ..CD31 may be a useful nonlysosomal marker of macrophages and their neoplastic counterparts (true histiocytic sarcomas). An immunohistochemical staining panel that includes CD31 and S100 facilitates the diagnosis of SHML and LCH...
  34. ncbi Vascular pathology in galactosialidosis
    Y Arai
    Department of Clinical Laboratory, National Center Hospital for Mental, Nervous and Muscular Disorders, Kodaira, Tokyo, Japan
    Ultrastruct Pathol 23:369-74. 1999
    ..Moreover, diffuse and various degrees of axonal damage, most likely caused by vascular disorder in cerebral or cerebellar white matter, was reported using the amyloid precursor protein (APP) immunohistochemical method...
  35. ncbi Cellular Ca2+ ATPase activity in diabetes mellitus
    C Spieker
    , , Germany
    Horm Metab Res 26:544-7. 1994
    ..There was no significant correlation of maximal Ca2+ ATPase activity to fasting serum glucose concentration and to HbA1 levels...
  36. ncbi Renal metabolism of uric acid in type I insulin-dependent diabetic patients: relation to metabolic compensation
    L Gonzalez-Sicilia
    Servicio de Medicina Interna, Hospital General Universitario, Murcia, Spain
    Horm Metab Res 29:520-3. 1997
    ..4 +/- 7.2 years) were studied under two situations, poor glycemic control (glycemia > 11 mmol/L and HbA1 c > 10%) and good glycemic control (glycemia < 6 mmol/L and HbA1 c < 8.5%)...
  37. ncbi [Influence of insulin-like growth factor 1 on PECAM-1 and ICAM-1 adhesion molecules expression in tumor necrosis factor alpha and hyperglycemia induced umbilical vein endothelial cells]
    Krzysztof Wnuczko
    Kliniki Neonatologii i Intensywnej Terapii Noworodka Uniwersyteckiego Szpitala Klinicznego w Białymstoku
    Wiad Lek 61:119-25. 2008
    ....
  38. ncbi Normal and neoplastic cells of brown adipose tissue express the adhesion molecule CD31
    Renato Rosso
    From the Department of Pathology, University of Pavia, IRCCS San Matteo Hospital, Pavia, Italy
    Arch Pathol Lab Med 130:480-2. 2006
    ..During the assessment of angiogenesis and vascular invasion in a thymic carcinoid tumor, we observed unexpected immunostaining for CD31 in perithymic brown fat nests...
  39. ncbi Assessment of risk for severe hypoglycemia among adults with IDDM: validation of the low blood glucose index
    B P Kovatchev
    University of Virginia Health Sciences Center, Charlottesville, 22908, USA
    Diabetes Care 21:1870-5. 1998
    ..To evaluate the clinical/research utility of the low blood glucose index (LBGI), a measure of the risk of severe hypoglycemia (SH), based on self-monitoring of blood glucose (SMBG)...
  40. ncbi Effect of different insulin administration modalities on vitamin D metabolism of insulin-dependent diabetic patients
    C Colette
    , , Montpellier, France
    Horm Metab Res 21:37-41. 1989
    ..in 3 groups of patients who were treated for several months with (i) conventional insulin therapy (group I, n = 17, HbA1 = 10.1 +/- 0.5%); (ii) continuous subcutaneous insulin infusion (CSII, group II, n = 11, HbA1 = 8.9 +/- 0...
  41. doi Increased lengthening rate decreases expression of fibroblast growth factor 2, platelet-derived growth factor, vascular endothelial growth factor, and CD31 in a rat model of distraction osteogenesis
    Jonathan R Schiller
    Department of Orthopaedics, Brown Medical School Rhode Island Hospital, Providence 02905, USA
    J Pediatr Orthop 27:961-8. 2007
    ....
  42. doi Vascular and lymphatic properties of the superficial and deep lamina propria in Barrett esophagus
    Hejin P Hahn
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 32:1454-61. 2008
    ..Further outcome studies are needed to evaluate the risk of vascular/lymphatic metastasis in BE patients with different levels of LP invasion...
  43. ncbi FasL-Fas interactions regulate neovascularization in the cornea
    Patrick M Stuart
    Departments of Ophthalmology and Visual Sciences, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Invest Ophthalmol Vis Sci 44:93-8. 2003
    ..Because Fas ligand (FasL) is highly expressed in the cornea, the role of this molecule in controlling corneal neovascularization was examined in this study...
  44. ncbi Quality control of intensified insulin therapy: HbA1 versus blood glucose
    F Bischof
    , Germany
    Horm Metab Res 26:574-8. 1994
    Since the measurement of HbA1 has become available to the diabetologists, the physicians and patients tend to rely exclusively on this parameter for the assessment of metabolic control...
  45. pmc Vascular density and phenotype around ductal carcinoma in situ (DCIS) of the breast
    N B Teo
    Pathology Department, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Br J Cancer 86:905-11. 2002
    ..The relationship between vascular density, grade, duct size and nuclear grade suggests that periductal angiogenesis increases with tumour growth rate but is unable to keep pace with the most rapidly growing lesions...
  46. ncbi [Usefulness of current and retrospective markers of glycemia for early prognostication of ischemic stroke in diabetics and non-diabetics]
    B Chmielewska
    Katedra i Klinika Neurologii, Akademii Medycznej w Lublinie
    Ann Univ Mariae Curie Sklodowska Med 54:261-7. 1999
    ..In the study we have assessed relations of fasting (1st-2nd day of illness) and pre-stroke glycaemia (measured as HbA1 and FA) with recent clinical manifestation and outcome within one month in 22 diabetics and 37 non-diabetics with ..
  47. pmc Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
    E Kriehuber
    Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, University of Vienna Medical School, Austria
    J Exp Med 194:797-808. 2001
    ..These results demonstrate that LECs and BECs constitute stable and specialized EC lineages equipped with the potential to navigate leukocytes and, perhaps also, tumor cells into and out of the tissues...
  48. ncbi Recipient cytokine genotypes for TNF-alpha and IL-10 and the minor histocompatibility antigens HY and CD31 codon 125 are not associated with occurrence or severity of acute GVHD in unrelated cord blood transplantation: a retrospective analysis
    Gesine Kogler
    José Carreras Eurocord Netcord Bank Germany, Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University, Moorenstrasse 5, Bldg 14 80, 40225 Dusseldorf, Germany
    Transplantation 74:1167-75. 2002
    ....
  49. ncbi Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours
    M Fukunaga
    Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan
    Histopathology 46:396-402. 2005
    ..D2-40 is a novel monoclonal antibody to a Mr 40 000 O-linked sialoglycoprotein that reacts with a fixation-resistant epitope in lymphatic endothelium...
  50. ncbi Insulin resistance in Fibrocalculous (tropical) pancreatic diabetes
    V Mohan
    Diabetes Research Centre, Madras, India
    Horm Metab Res 20:746-8. 1988
    ..001). There was no significant difference between the mean fasting plasma glucose or HbA1 between the FCPD and NIDDM patients...
  51. ncbi Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: the effect of improved glycemic control
    Chaiyasit Sittiwet
    Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland
    Atherosclerosis 194:465-72. 2007
    ..After the 2-6 months follow-up, the mean value of HbA1(c) decreased from 10.8% to 8.6% (p=0.001)...
  52. ncbi Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis
    Claus Cursiefen
    Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 45:1117-24. 2004
    ..This study was undertaken to investigate whether deficiencies of these factors altered developmental and inflammation-induced angiogenesis in the cornea and developmental angiogenesis of the iris of mice...
  53. doi Expression of adhesion molecules in first trimester spontaneous abortions and their role in abortion pathogenesis
    Gamze Yurdakan
    Department of Pathology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey
    Acta Obstet Gynecol Scand 87:775-82. 2008
    ..To the best of our knowledge, this is the first study to investigate adhesion molecules in spontaneous abortions...
  54. pmc Recombinant vascular basement-membrane-derived multifunctional peptide inhibits angiogenesis and growth of hepatocellular carcinoma
    You Hua Wu
    Laboratory of Medicine Engineering, Medical College, Hunan Normal University, Changsha, Hunan Province, China
    World J Gastroenterol 15:1744-50. 2009
    ..To investigate the anti-angiogenic and anti-tumor activities of recombinant vascular basement membrane-derived multifunctional peptide (rVBMDMP) in hepatocellular carcinoma (HCC)...
  55. pmc Human embryonic stem cells hemangioblast express HLA-antigens
    Grzegorz Wladyslaw Basak
    Rebecca and John Moore s Cancer Center, University of California, La Jolla, CA 92093, USA
    J Transl Med 7:27. 2009
    ..We hypothesized that these cells with dual hematopoietic/endothelial potential could be used in future regenerative medicine...
  56. ncbi Limited joint mobility and lipodystrophy in children and adolescents with insulin-dependent diabetes mellitus
    T Kakourou
    First Department of Pediatrics, Athens University, Greece
    Pediatr Dermatol 11:310-4. 1994
    ..7 years, who had insulin-dependent diabetes mellitus (IDDM) for 4.5 +/- 3.7 years and glycosylated Hb values (HbA1) of 10.5% +/- 4.5%, were examined for limited joint mobility (LJM) and lipodystrophy...
  57. ncbi Epithelioid cell histiocytoma--histogenetic and kinetics analysis of dermal microvascular unit dendritic cell subpopulations
    Jeffrey S Silverman
    Southside Hospital, Department of Pathology, Bay Shore, NY, USA
    J Cutan Pathol 30:415-22. 2003
    ..Thought to arise from dermal dendrocytes, most ECH contain approximately 50% FXIIIa+ histiocytic dendrocytes, but not all lesional cells express FXIIIa. A putative fibroblastic component has not been characterized...
  58. ncbi [Correlative study of distribution of brain tumor stem cell with micro-vascular system]
    Ming Wu Li
    Department of Neurosurgery, Affiliated Provincial Hospital, Anhui Medical University, Hefei 230001, China
    Zhonghua Yi Xue Za Zhi 90:305-9. 2010
    ..The relationship of BTSC distribution with micro-blood vessels was analyzed using morphometry...
  59. ncbi Adjunctive use of tolazamide in newly-diagnosed diabetic children
    R Sanders
    University of Rochester Medical Center, Department of Pediatrics, New York
    Horm Metab Res 22:576-80. 1990
    ..Monthly comparison of the HbA1 values between groups revealed no statistical difference; likewise, the fasting serum C-peptide values were not ..
  60. ncbi Oligodendroglioma: HMB-45 positivity using catalyzed signal amplification method: an immunohistochemical (HMB-45, CD31, p53, Mib-1) and ultrastructural study
    G L Taddei
    Department of Human Pathology and Oncology, University of Florence, Italy
    Appl Immunohistochem Mol Morphol 9:35-41. 2001
    ..0213). Proliferation rate, evaluated with Mib-1, was unrelated to survival, but proved greater in recurrences (10 of 11 cases) than in primary tumors (7 of 19 lesions; P = 0.007)...
  61. ncbi Flexor tendon blood vessels
    M E Jones
    RAFT Institute, Mount Vernon Hospital Northwood, Middlesex, UK
    J Hand Surg Br 25:552-9. 2000
    ..We therefore recommend the use of hindpaw tendons when using the rabbit as a flexor tendon experimental model. This is because its vascular pattern is similar to that of the human flexor digitorum profundus...
  62. ncbi Evidence that CD31, CD49b, and CD62L are immunodominant minor histocompatibility antigens in HLA identical sibling bone marrow transplants
    E Maruya
    Department of Research, Kyoto Red Cross Blood Center, Kyoto, Japan the Department of Internal Medicine, Saku Central Hospital, Nagano, The Department of Transfusion Medicine, Yamaguchi University Hospital, Japan
    Blood 92:2169-76. 1998
    ..03) and CD62L + CD49b (P = . 004, Pcorrected = .078) was associated with acute GVHD. Therefore, CD31, CD49b, and CD62L might be candidates for immunodominant mHa...
  63. pmc Neoadjuvant multidrug chemotherapy including high-dose methotrexate modifies VEGF expression in osteosarcoma: an immunohistochemical analysis
    Barbara Rossi
    Department of Orthopaedics and Traumatology, Catholic University, Agostino Gemelli Hospital, Rome, Italy
    BMC Musculoskelet Disord 11:34. 2010
    ....
  64. ncbi Elevated plasma endothelial microparticles: preeclampsia versus gestational hypertension
    Victor H Gonzalez-Quintero
    Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, University of Miami School of Medicine, PO Box 016960 R 136, Miami, FL 33101, USA
    Am J Obstet Gynecol 191:1418-24. 2004
    ....
  65. pmc ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: implications for vascular repair
    Karthikeyan Mythreye
    Department of Medicine, Duke University Medical Center, 209 MSRB1 Research Drive, Durham, NC 27710, USA
    Biochim Biophys Acta 1781:703-9. 2008
    ..Our results provide the first evidence that exogenous free ApoA-I has the capacity to change the characteristics of progenitor cell populations and suggests a novel mechanism by which HDL may mediate its cardiovascular benefits...
  66. ncbi Expression of CD31, Met/hepatocyte growth factor receptor and bone morphogenetic protein in bone metastasis of osteosarcoma
    K Arihiro
    Second Department of Pathology, Hiroshima University School of Medicine, Hiroshima, Japan
    Pathol Int 51:100-6. 2001
    ....
  67. ncbi Significance of monocyte chemotactic protein-1 and thymidine phosphorylase in angiogenesis of human cardiac myxoma
    Tianshu Zhang
    Second Department of Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Circ J 67:54-60. 2003
    ..These results indicate that in cardiac myxoma, MCP-1 and TP may be regarded as important angiogenic signals accompanying growth...
  68. ncbi Absence of in vivo generalized pro-inflammatory endothelial activation in severe, early-onset preeclampsia
    Rogier B Donker
    Department of Obstetrics and Gynecology, Groningen University Institute for Drug Exploration, University Medical Center Groningen, Groningen, The Netherlands
    J Soc Gynecol Investig 12:518-28. 2005
    ..Therefore, this study aimed to investigate the presence of generalized proinflammatory endothelial activation in severe, early-onset preeclampsia in vivo...
  69. ncbi Multivariable analysis of serum 3,5,3'-L-triiodothyronine concentration in patients of diabetes mellitus by blood glucose level and body weight
    T Yagura
    Tenri Hospital, Japan
    Horm Metab Res 22:237-40. 1990
    ..Haemoglobin A1 (HbA1) was used as an index of hyperglycemia...
  70. ncbi Regulation of CD31 expression and interleukin-4 production by human cord blood CD4+ T cells with interleukin-4 and interleukin-7
    K Katamura
    Department of Pediatrics, Faculty of Medicine, Kyoto University, Japan
    Pediatr Int 42:126-33. 2000
    ....
  71. ncbi CD34-positive stromal cells and alpha-smooth muscle actin-positive stromal cells in the tumor capsule of skin sweat gland neoplasms
    Hirofumi Nakayama
    First Department of Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 52:25-30. 2002
    ....
  72. ncbi Endothelial microparticles released in thrombotic thrombocytopenic purpura express von Willebrand factor and markers of endothelial activation
    Joaquin J Jimenez
    Wallace H Coulter Platelet Laboratory, Division of Hematology Oncology, University of Miami School of Medicine, Miami, FL 33136, USA
    Br J Haematol 123:896-902. 2003
    ..The ratio of CD31+/42b- to CD62E+ EMP exhibited a pattern consistent with activation. In conclusion, our studies indicate endothelial activation in TTP. EMP that co-express VWF and CD62E could play a role in the pathogenesis of TTP...
  73. ncbi Angiogenic switching in the alveolar capillaries in primary lung adenocarcinoma and squamous cell carcinoma
    Chizuko Morishita
    Department of Molecular Pathology, Institute of Gerontology, Field of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kanagawa, Japan
    J Nihon Med Sch 74:344-54. 2007
    ..Suppression of angiogenic switching in SCC implies that factors other than VEGF-VEGFR interaction, such as physical contact and compression of tumor cells, might play a critical role in alveolar capillaries...
  74. pmc Interleukin-3 promotes hemangioblast development in mouse aorta-gonad-mesonephros region
    Wen Yan He
    Department of Cell Biology, Institute of Basic Medical Sciences, Beijing, China
    Haematologica 95:875-83. 2010
    ..In mouse E7.0-7.5 embryos, the hemangioblast can be identified by a clonal blast colony-forming cell (BL-CFC) assay or single cell OP9 co-culture. However, the ontogeny of the hemangioblast in mid-gestation embryos is poorly defined...
  75. doi Polychromatic flow cytometry analysis of CD34+ hematopoietic stem cells in cryopreserved early preterm human cord blood samples
    F D'Alessio
    CEINGE Biotecnologie Avanzate, Naples, Italy
    Cytometry A 79:14-24. 2011
    ..Taken together, these results evidence the hematopoietic peculiarity of hEPCB, potentially useful for highlighting early steps of human hematolymphopoiesis as well as for developing novel strategies of stem cell-based therapy...
  76. ncbi Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member
    S Deaglio
    Dipartimento di Genetica, Biologia e Chimica Medica, Universita di Torino, Italy
    J Immunol 160:395-402. 1998
    ..These results suggest that the interplay between CD38 and its ligand CD31 is an important step in the regulation of cell life and of the migration of leukocytes (and CD38+ cancer cells) through the endothelial cell wall...
  77. ncbi Angiogenesis during follicular development in the primate and its inhibition by treatment with truncated Flt-1-Fc (vascular endothelial growth factor Trap(A40))
    C Wulff
    Medical Research Council, Human Reproductive Sciences Unit, EH3 9ET Edinburgh, United Kingdom
    Endocrinology 142:3244-54. 2001
    ..The ability of VEGF trap treatment to severely restrict follicular angiogenesis establishes that VEGF is the major regulator of this process in the primate ovary...
  78. ncbi Association between intracranial plasmacytoma and multiple myeloma: clinicopathological outcome study
    T H Schwartz
    Department of Neurosurgery, Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, NY 10021, USA
    Neurosurgery 49:1039-44; discussion 1044-5. 2001
    ..Attention has recently been focused on the role of the cell adhesion molecules CD56 and CD31 in the pathogenesis of myeloma. No such information is available for intracranial plasmacytomas and myeloma-associated lesions...
  79. ncbi Does bromocriptine improve glycemic control of obese type-2 diabetics?
    Ashraf Aminorroaya
    Isfahan Endocrinology and Metabolism Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran
    Horm Res 62:55-9. 2004
    ..In recent years, bromocriptine has been tried with controversial results. In present study, the effect of bromocriptine on glycemic control was evaluated in obese type-2 diabetic patients...
  80. ncbi Mesenchymal stem cells participate in angiogenesis and improve heart function in rat model of myocardial ischemia with reperfusion
    Junming Tang
    Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, People s Republic of China
    Eur J Cardiothorac Surg 30:353-61. 2006
    ..The effect of transplanted mesenchymal stem cells (MSCs) on the left ventricular (LV) function and morphology in a rat myocardial infarct heart with reperfusion model were analyzed...
  81. ncbi Analysis of immunohistochemical markers in bone marrow sections to evaluate for myelodysplastic syndromes and acute myeloid leukemias
    Cherie H Dunphy
    Divisions of Hematopathology, Departments of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Appl Immunohistochem Mol Morphol 15:154-9. 2007
    ..We compare the usefulness of immunohistochemistry (IHC) [ie, CD34, CD117, myeloperoxidase (MPO), Hemoglobin A1 (HbA1), and terminal deoxynucleotidyl transferase (TdT)] of BM sections (IHC-BM) with BMA, bone marrow touch preparation (..
  82. doi Role and mechanism of vasculogenic mimicry in gastrointestinal stromal tumors
    Baocun Sun
    Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, People s Republic of China
    Hum Pathol 39:444-51. 2008
    ..033, respectively). We conclude that VM in GISTs is an unfavorable prognostic sign and that patients with VM-positive tumors are prone to suffer liver metastasis. Both MMP-2 and MMP-9 play an important role in VM formation in GISTs...
  83. doi Distribution of LYVE-1 and CD31 in postnatal rat masseter muscle
    Iwao Sato
    Department of Anatomy, School of Life Dentistry at Tokyo, Nippon Dental University, 1 9 20 Fujimi, Chiyoda ku, Tokyo, Japan
    Ann Anat 190:329-38. 2008
    ....
  84. pmc Lymphovascular invasion in colorectal cancer: an interobserver variability study
    Elizabeth I Harris
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Surg Pathol 32:1816-21. 2008
    ..This study was undertaken to examine such interobserver variability, and we hypothesized that the use of immunohistochemical markers for vascular and lymphatic channels could improve interobserver agreement...
  85. doi The role of thrombosis as a mechanism of exacerbation in venous and combined venous lymphatic vascular malformations of the orbit
    Ioannis Mavrikakis
    Department of Ophthalmology and Visual Sciences, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Ophthalmology 116:1216-24. 2009
    ....
  86. ncbi Sustained normoglycemia and remission phase in newly diagnosed type I diabetic subjects. Comparison between continuous subcutaneous insulin infusion and conventional therapy during a one year follow-up
    E Edelmann
    III. Medizinische Abteilung and Forschergruppe Diabetes, , , Germany
    Horm Metab Res 19:419-21. 1987
    ..b>HbA1, glycosylated serum proteins and mean blood glucose (MBG) as parameters of metabolic control were determined ..
  87. ncbi Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice
    B Nieswandt
    Department of Molecular Oncology, General Surgery, University of Witten Herdecke, Wuppertal, Germany
    Blood 96:2520-7. 2000
    ....
  88. pmc Comparative study of the cyclization reactions of three bacterial cyclomaltodextrin glucanotransferases
    Y Terada
    Biochemical Research Laboratory, Ezaki Glico Co, Ltd, 4 6 5 Utajima, Nishiyodogawa, Osaka 555 8502, Japan
    Appl Environ Microbiol 67:1453-60. 2001
    ..These three enzymes also differ in their hydrolytic activities, which seem to accelerate the conversion of larger cycloamyloses into smaller cycloamyloses...
  89. ncbi Luteal angiogenesis: prevention and intervention by treatment with vascular endothelial growth factor trap(A40)
    C Wulff
    Medical Research Council Human Reproductive Sciences Unit, Edinburgh, Scotland, United Kingdom EH3 9ET
    J Clin Endocrinol Metab 86:3377-86. 2001
    ..Luteal Flt mRNA expression is dependent upon VEGF, and VEGF inhibition results in abortive increases in expression of VEGF, angiopoietin-2, and Tie-2...
  90. ncbi Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells
    Patricia F Lalor
    Liver Research Laboratories, University of Birmingham Institute of Clinical Science, Medical Research Council Center for Immune Regulation, Edgbaston, Birmingham, United Kingdom
    J Immunol 169:983-92. 2002
    ..Moreover, since VAP-1 is induced on nonhepatic endothelium in response to inflammation, its ability to support lymphocyte transendothelial migration may be an important systemic function of VAP-1...
  91. ncbi Establishment and characterization of an angiosarcoma-derived cell line, AS-M
    Vera Krump-Konvalinkova
    Institute of Pathology, Johannes Gutenberg University Mainz, Germany
    Endothelium 10:319-28. 2003
    ..5 presented characteristics suggestive of tumor cells, they did not develop into tumors when inoculated subcutaneously into nude mice. The cell line AS-M.5 could be a useful model system to study endothelial pathobiology in vitro...
  92. ncbi Localization of marginal zone macrophages is regulated by C-C chemokine ligands 21/19
    Manabu Ato
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    J Immunol 173:4815-20. 2004
    ..Deficiency of CCL19 and CCL21, as also previously observed in mice infected with L. donovani, may thus account for the selective loss of MZM seen during this infection...
  93. ncbi Establishment of an immortalized PARP-1-/- murine endothelial cell line: a new tool to study PARP-1 mediated endothelial cell dysfunction
    Ana Carrillo
    Transplant Unit, University Hospital Virgen de la Arrixaca, Murcia, Spain
    J Cell Biochem 94:1163-74. 2005
    ..This cell line should provide, for the first time, a valuable tool to study PARP-1 pathways in endothelial cell dysfunction...
  94. ncbi A case of primary uterine angiosarcoma: magnetic resonance imaging and computed tomography findings
    Y Konishi
    Division of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Int J Gynecol Cancer 17:280-4. 2007
    ..In addition, findings of a strongly enhanced lesion on gadolinium-enhanced T1-weighted MRI and contrast-enhanced CT also support the diagnosis of angiosarcoma...
  95. doi Immunohistochemical analysis of P-Selectin as a possible marker of vitality in human cutaneous wounds
    J A Ortiz-Rey
    Department of Pathology, POVISA Hospital, Vigo, Spain
    J Forensic Leg Med 15:368-72. 2008
    ..Moreover, P-Selectin has been detected in post-mortem injuries and it is not specific to vital injuries. Microscopic evaluation becomes difficult after autolysis/putrefaction...
  96. doi Further identification of the hyperunstable alpha-globin chain variant Hb Heraklion [codons 36/37 (-CCC); Pro-->0 (alpha1)] in Greek cases with co-inherited alpha+-thalassemia mutations
    Varvara Douna
    Hematology Laboratory, P and A Kyriakou Children s Hospital, Athens, Greece
    Hemoglobin 32:379-85. 2008
    ..Clinical, hematological and biochemical findings in all cases, including a follow-up evaluation of the original case, are described. All the cases originated from the Greek island of Crete...
  97. doi Angiogenic response to extracorporeal shock wave treatment in murine skin isografts
    Alexander Stojadinovic
    Combat Wound Initiative Program, Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
    Angiogenesis 11:369-80. 2008
    ..These findings suggest that early pro-angiogenic and anti-inflammatory effects of ESWT promote tissue revascularization and wound healing by augmenting angiogenesis and dampening inflammation...
  98. doi Transcriptional profiling of CD31(+) cells isolated from murine embryonic stem cells
    Devi Mariappan
    Center of Physiology and Pathophysiology, Institute of Neurophysiology, and Center of Molecular Medicine, University of Cologne, Germany
    Genes Cells 14:243-60. 2009
    ..The transcriptomic characterization of CD31(+) cells enables an in vitro functional genomic model to identify genes required for angiogenesis...
  99. pmc Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance
    Michele Dal-Bo
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano PN, Italy
    J Transl Med 7:76. 2009
    ..g. specific receptor/ligand interactions, such as CD38/CD31 or CD49d/VCAM-1. A putative final model, discussing the pathogenesis and the clinicobiological features of CLL in relationship of these factors, is also provided...
  100. pmc Localization of vascular adhesion protein-1 (VAP-1) in the human eye
    Lama Almulki
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 325 Cambridge Street, 3rd Floor, Boston, MA 02114, USA
    Exp Eye Res 90:26-32. 2010
    ..Furthermore, VAP-1 expression in the ocular vasculature is heterogeneous, with the vessels of the optic nerve and the retina showing highest expressions. These results characterize VAP-1 expression in human ocular tissues...

Research Grants98

  1. Seyedtaghi Takyar; Fiscal Year: 2015
    ....
  2. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2012
    ....
  3. Interaction of thrombospondin-1 with alpha9beta1 integrin in glioma angiogenesis
    Cezary Marcinkiewicz; Fiscal Year: 2012
    ..Investigation of this receptor may be beneficial for cancer as well as for cardiovascular disease having patients, because regulation of vascularization process is important in these pathologies. ..
  4. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    ..These results have implications for understanding the possibility to use trophic factors as ADT in MDD. ..
  5. JAMES MICHAEL DUNLEAVEY; Fiscal Year: 2015
    ..Overall this study should provide novel therapeutic targets which could be used in conjunction with current anti-angiogenic therapies to improve cancer outcomes. ..
  6. Christopher D Kontos; Fiscal Year: 2014
    ..Furthermore, these studies may lead to effective therapies for the treatment of PAD. ..
  7. Peter J Newman; Fiscal Year: 2016
    ..The goal of this proposal is to improve our understanding of the function of this novel vascular cell adhesion and signaling molecule in the blood and vascular cells in which it is expressed. ..
  8. Fatal Attration: T lymphocytes and liver endothelial cell during sepsis.
    NOELLE A HUTCHINS; Fiscal Year: 2012
    ..There are approximately 700,000 septic cases annually, and it has a mortality of 30%. We plan to use our proposed research strategies to discover a novel therapeutic target to understand and treat septic patients. ..
  9. The role of endothelial Notch signaling in murine lung branching morphogenesis
    Eric Jelin; Fiscal Year: 2010
    ..This project seeks to define the relationship between signaling in growing lung blood vessels and the associated coordinated development of airways. ..
  10. William A Muller; Fiscal Year: 2016
    ..The results of these studies will contribute significantly to our understanding of the regulation of diapedesis and provide new targets for anti-inflammatory therapy. ..
  11. INDER MOHAN VERMA; Fiscal Year: 2014
    ..We believe that the proposed experiments will allow us to understand the initiation, progression and maintenance of GBMs. We hope that our efforts to identify the targets will allow therapeutic intervention of this deadly disease. ..
  12. Identification of Novel Endothelial Progenitor Cells
    Young Sup Yoon; Fiscal Year: 2010
    ..In this proposal, we propose to identify genuine EPCs which have vasculogenic and/or angiogenic properties by narrow downing the CD31 subfractions. ..
  13. Endothelial Progenitor Cells for Assessing Toxicological Response Variability in
    JOHN WILLIAM LUDLOW; Fiscal Year: 2013
    ..ECFC-based toxicological assays can become an invaluable tool for functional assessment of human genetic diversity and identification of population subgroups most vulnerable to chemical hazards. ..
  14. Imad Shureiqi; Fiscal Year: 2014
    ..Confirmation of the tested hypothesis could lead to developing PPAR-d-targeted therapy to inhibit tumorigenesis. ..
  15. Tissue Factor/Vlla modulation in Ocular angiogenesis
    PATRICIA PHILLIPS; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  16. Michael J Zigmond; Fiscal Year: 2014
    ....
  17. Shehla Pervin; Fiscal Year: 2015
    ..Increased understanding of the critical role of ERK1/2 signaling in MCSCs from AA patients and may provide novel targets for therapeutic drug design. ..
  18. NEUTROPHILS TRANSENDOTHELIAL MIGRATION: MOLECULAR EVENTS
    Alan Burns; Fiscal Year: 2004
    ..The proposed research will provide new data and insights for the design of anti-inflammatory therapies that target the multistep process of leukocyte migration. ..
  19. Intervention models for thyroid proliferative disease using a bioactive food comp
    Raj K Tiwari; Fiscal Year: 2013
    ..This basic translational research is directed to reduce possible unnecessary surgery in TPD using bioactive food component, DIM, and determining the cellular and molecular basis of the gender bias of TPD. ..
  20. Urokinase, Neutrophil Activation and Acute Lung Injury.
    Gang Liu; Fiscal Year: 2013
    ....
  21. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2011
    ....
  22. HUCBC modulation of Alzheimer's-like pathology and behavioral changes
    Jun Tan; Fiscal Year: 2012
    ..Because it is our long-term goal to move U-CORD-CELL" into human trials for patients with mild to moderate AD, the proposal culminates in a completed investigational new drug (IND) application for submission to the FDA. ..
  23. Charlotte A Peterson; Fiscal Year: 2016
    ....
  24. Negative regulation of platelet activity
    DEBRA KAY NEWMAN; Fiscal Year: 2010
    ..We expect that information derived from this investigation has the potential to lead to improved diagnosis and treatment of bleeding disorders, myocardial infarction and stroke. ..
  25. Functional dissection of human adipose and bone marrow-derived MSC phenotypes
    Jan A Nolta; Fiscal Year: 2010
    ..abstract_text> ..
  26. Cell Specific Localization of Altered Gene Expression in Pulmonary Hypertension
    Marlene Rabinovitch; Fiscal Year: 2012
    ..abstract_text> ..
  27. Integrating Quantitative Histological Image and Vascular Density Patterns for Pro
    Anant Madabhushi; Fiscal Year: 2010
    ..Data accrual will be done at UPENN while algorithmic development for computerized image analysis and classification will be carried out at RU. ..
  28. Myogenic Potential of Extraocular Muscle Satellite Cells
    Linda K McLoon; Fiscal Year: 2010
    ..If these hypotheses are true, ultimately we hope to exploit this by using identified myogenic precursor cells from EOM as a new source of donor cells in myoblast therapy in mice models of muscle injury and DMD. ..
  29. Imaging and Modifying Hypoxia in Head and Neck Squamous Cell Tumors
    Sydney M Evans; Fiscal Year: 2013
    ..The use of the hypoxia imaging agents EF5 (in tissue sections) and 18F-EF5 for PET scanning will define which patients and what therapies will be most effective in order to improve patient outcome and quality of life. ..
  30. Design of novel c-Met inhibitors inspired by olive phenolics
    Khalid A El Sayed; Fiscal Year: 2013
    ..Anticipated new information will facilitate important therapeutic advances for alleviation and prevention of c-Met dependent malignancies. ..
  31. The Identification and Study of a Lung Mesenchymal Stem Cell
    Ross S Summer; Fiscal Year: 2010
    ..abstract_text> ..
  32. Synergistic effects of HIV and age on naive CD4+ T-cell senescence
    BETH DEIRDRE JAMIESON-KARAVODIN; Fiscal Year: 2012
    ....
  33. Local Warming: Effects on Wound Infection and Healing
    JoAnne Whitney; Fiscal Year: 2007
    ..2.3. Perfusion (BF) in the surgical incision on postoperative days 3, 5 and 9 using Laser Doppler Flowmetry (LDF). ..
  34. Defects of Thymic Output in Wiskott-Aldrich Syndrome
    EILEEN REMOLD O DONNELL; Fiscal Year: 2006
    ....
  35. Aging, Angiogenesis, and the Neuropeptide Y (NPY) System
    Joanna Kitlinska; Fiscal Year: 2002
    ..abstract_text> ..
  36. Mechanism of Alcohol/Alcoholism-induced Liver Neoplasia
    CHRISTIAN MAXIMILLIAN SCHMIDT; Fiscal Year: 2010
    ..Such an animal model will be an invaluable tool for studying the mechanism by which alcohol exposure causes liver cancer and also further our understanding of the mechanisms by which alcohol causes cancer in general. ..
  37. REGULATION OF CELL DEATH IN EOSINOPHILOPOIESIS
    Kimm Hamann; Fiscal Year: 1999
    ..We anticipate that these studies will establish a novel strategy of examining eosinophilopoiesis and will elucidate mechanisms of matrix-mediated regulation of hematopoiesis. ..
  38. PROGNOSIS OF METASTATIC DISEASE IN EARLY BREAST CANCER
    Orhan Nalcioglu; Fiscal Year: 2005
    ..The successful outcome of the current proposal should enhance the accuracy of the prognostic factors and reduce the treatment-associated morbidity while also reducing the long-term mortality by selecting the "correct treatment." ..
  39. ENDOCAM/PECAM--A NOVEL VASCULAR CELL ADHESION MOLECULE
    Steven Albelda; Fiscal Year: 1999
    ....
  40. Biomarkers for protection against complicatios and beta-cell destruction
    George King; Fiscal Year: 2009
    ..Surprisingly, no significant correlations were found between the presence of complications and HbA1 c, duration of disease and the presence of C-peptide...
  41. Role of LIBC in Inflammatory Breast Cancer Phenotype
    Celina Kleer; Fiscal Year: 2007
    ..Also, understanding the role of WISP3 will shed light on the mechanisms of cancer development in general and serve as a model for other related CCN genes involved in carcinogenesis. ..
  42. Angioprevention of Lung Tumorigenesis by Silibinin
    Rajesh Agarwal; Fiscal Year: 2009
    ..Accordingly, completion of the studies proposed in this grant would position us for a pilot clinical trial with silibinin in lung cancer patients and in those suspected of being at high risk for lung cancer development. ..
  43. TOMOGRAPHIC/SPECTRAL IMAGING OF FGF-MED ANGIOGENESIS
    Dorothea Becker; Fiscal Year: 2001
    ..abstract_text> ..
  44. ESTROGEN-DEPENDENT TUMOR GROWTH AND ANGIOGENESIS
    Jack Gorski; Fiscal Year: 1999
    ..These new lines will be used to fine map these genes, leading to our third major aim; defining tumor growth and angiogenesis genes at the molecular level. We will map the genes with high resolution on the order of 1 centiMorgan. ..
  45. Preventive Health Care Use in Elderly Cancer Survivors
    ALEXANDER MCBEAN; Fiscal Year: 2006
    ..Association's recommended diabetes quality of care measures: the determination of serum hemoglobin Alc (HbA1 c) and low-density lipids (LDL-C), eye examination, and testing for diabetic nephropathy in persons who have ..
  46. STRUCTURE FUNCTION ANALYSIS OF PECAM 1
    Horace Delisser; Fiscal Year: 1999
    ....
  47. INVESTIGATION OF ANGIOGENIC FUNCTION IN CANCER BY MRI
    Orhan Nalcioglu; Fiscal Year: 2001
    ..All of these goals are major issues in health care of breast-cancer patients and the successful outcome of the proposed investigation will help reduce the human and economic costs of breast cancer. ..
  48. Matrix metalloproteinases and diabetic nephropathy
    KATHRYN THRAILKILL; Fiscal Year: 2005
    ..in MMPFl'lMP/IGFconcentrations and differences in glycemic control at the time of study, as indicated by HbA1 c measurements and concurrent (72 hour) Continuous Subcutaneous Glucose Monitoring (CGMS)...
  49. Phase 2 Study of Anti Vegf Antibody in Melanoma
    William Carson; Fiscal Year: 2002
    ..Information gained from this trial will help us to understand the mechanism of action of anti-angiogenic drugs and help us to plan future studies in melanoma and other solid tumors. ..
  50. PALM-TOP DIETARY MANAGER FOR CHILDREN WITH DIABETES
    SERGEY SIROTININ; Fiscal Year: 2003
    ..respect to: (a) its effectiveness to improve dietary self-management; (b) its impact on blood glucose regulation (HbA1 levels); and (c) user's satisfaction...
  51. Proteinase Modulation Diring T-Cell Endothelial Adhesion
    Joseph A Madri; Fiscal Year: 2010
    ..Specifically we will use WT, CD31 KO, MMP-2 KO, MMP-9 KO, MMP-14 and -/- and CD44 KO mice, and bone marrow chimeric mice generated from these mice. ..
  52. Contrast-Enhanced Ultrasound Detection of Angiogenesis
    Flemming Forsberg; Fiscal Year: 2004
    ..If successful, this project will permit non-invasive ultrasound evaluations of anti-angiogenic tumor therapies in animals as well as humans. ..
  53. Subharmonic Microbubble Signals for Pressure Estimation
    Flemming Forsberg; Fiscal Year: 2008
    ..This will allow potentially life-threatening diseases, such as increased pressure in the liver, to be diagnosed early. [unreadable] [unreadable] [unreadable]..
  54. Periodontal Therapy: Effects on Glycemic Control in Community Health Centers
    George Taylor; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. Diabetes Associations with Caries and Tooth Loss
    George Taylor; Fiscal Year: 2005
    ..Results may also impact on existing clinical practice protocols, and promote new public policy in matters related to diabetes. ..
  56. TREATING PERIODONTAL INFECTION: GLYCEMIC CONTROL
    George Taylor; Fiscal Year: 2002
    ..abstract_text> ..
  57. TUMOR OXYGENATION, VASCULARIZATION, AND RADIORESPONSE
    Bruce Fenton; Fiscal Year: 2009
    ..These results with lead to the more rational and optimal design of effective combined therapies, thereby ultimately accelerating their implementation into clinical protocols. ..
  58. PECAM-1 and Alveolization
    Horace Delisser; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  59. Reciprocal regulation of SDF-1 between marrow and lung during acute lung injury
    Benjamin T Suratt; Fiscal Year: 2010
    ..The studies we propose are expected to improve our limited understanding of this phase of ALI, and could eventually lead to improved therapies for a condition that continues to be all too often fatal. ..
  60. Study of anti-angiogenesis enhanced radiotherapy
    Robert Griffin; Fiscal Year: 2008
    ..The information to be obtained in this study will be a vital part of design and implementation of large animal and human clinical trials. ..
  61. Gene therapy for treatment of craniofacial dysplasia
    Stephanos Kyrkanides; Fiscal Year: 2004
    ..Completion of this study will aid in the development of novel therapies for the management of genetic disorders. ..
  62. ENHANCEMENT OF PDT USING BIOLOGICAL RESPONSE MODIFIERS
    David A Bellnier; Fiscal Year: 2010
    ....
  63. Development of Digital SNP Analysis in Cancer Detection
    Ie Ming Shih; Fiscal Year: 2005
    ..Thus, the encouraging results from this study will ensure the detection of AI in plasma a promising cancer research direction for further exploration. ..
  64. Cell type gene delivery and alcoholic liver disease
    Michael Wheeler; Fiscal Year: 2006
    ..In addition, through didactic training, and interactions with his mentor and key faculty, the applicant will acquire new skills that will allow him to become a successful member of the alcohol research community. ..
  65. Translational Immunology Core's FACSAria Cell Sorter
    Frederic Preffer; Fiscal Year: 2008
    ..Advances in medicine based on similar past work today permit curative kidney and bone marrow transplantations as well as treatments for certain autoimmune and infectious disease. ..
  66. Recombinant FIV vectors for the delivery of siRNA therapy to joints
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  67. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2004
    ..In addition, this work has the potential to provide new biomarkers with which to assess lung cancer risk and its modulation. ..
  68. The Glycosylation Gap and Diabetic Complications
    Robert Cohen; Fiscal Year: 2005
    ..The proposal therefore has potentially important basic science, clinical and population implications. ..
  69. Chemo-prevention of UVB-induced Basal Cell Carcinomas+/*
    Mohammad Athar; Fiscal Year: 2004
    ....
  70. Heme oxygenase and cerebral vascular injury
    Helena Parfenova; Fiscal Year: 2008
    ..Better understanding of the mechanisms of postictal cerebral vascular dysfunction is needed to improve the long-term neurological outcome in human newborns. ..
  71. Behavioral intervention and adherence in hemodialysis
    Alan Christensen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  72. ADHERENCE AND ADJUSTMENT IN END-STAGE RENAL DISEASE
    Alan Christensen; Fiscal Year: 2003
    ..The knowledge generated will add to a growing body of literature that suggests psychosocial assessment information can be useful in the selection f the most beneficial renal treatment modality for a particular patient. ..
  73. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    Linda DiMeglio; Fiscal Year: 2004
    ..We will characterize the changes effected by oral bisphosphonate therapy and compare them to a regimen of intravenous bisphosphonate therapy in a group of children with OI. ..
  74. Transcription Factor Reporter Technology
    Alexei Bogdanov; Fiscal Year: 2006
    ..abstract_text> ..
  75. Differentiation of Glioma from Radiation Injury Using Cellular MRI
    Syed Ali; Fiscal Year: 2008
    ..This magnetic labeling technique will also help investigators to track the injected CTL in the body as well as in the targeted areas by magnetic resonance imaging (MRI). [unreadable] [unreadable] [unreadable]..
  76. Does peripheral localized chronic inflammation predispose to neurodegeneration?
    Stephanos Kyrkanides; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  77. Origin of HSC from Embryonic Stem Cells
    Elias Zambidis; Fiscal Year: 2008
    ..The success of these goals will lay the groundwork for characterizing human stem cells not available by any other means. ..
  78. Progesterone regulation of human luteal cell viability
    John Peluso; Fiscal Year: 2006
    ..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. [unreadable] [unreadable]..
  79. Protein Kinase G Regulation of Granulosa Cell Viability
    John Peluso; Fiscal Year: 2006
    ..We now propose to test this hypothesis using biochemical, genetic, imaging and cell biological techniques. [unreadable] [unreadable]..
  80. Cellular MRI in Glioma and Radiation Necrosis
    Ali Syed Arbab; Fiscal Year: 2010
    ..Early detection of recurrent or metastatic glioma as well as early differentiation of glioma from radiation necrosis will help clinician to tackle the devastating neurological disease. ..
  81. OSTEOCLASTIC PHOSPHOTYROSYL PHOSPHATASE AND RESORPTION
    KIN HING LAU; Fiscal Year: 2002
    ....
  82. VASO-OCCLUSIVE PROCESSES IN SICKLE CELL RETINOPATHY
    Gerard Lutty; Fiscal Year: 2006
    ..abstract_text> ..
  83. APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    Alan Verkman; Fiscal Year: 2006
    ..abstract_text> ..
  84. OXYGEN AND LIGHT DEPENDENCY OF PHOTODYNAMIC THERAPY
    Barbara Henderson; Fiscal Year: 2004
    ..Similarly, PDT destroyed tumor cells may provide tumor antigen to differentiating dendritic cells generated by preceding delivery of GM-CSF. ..
  85. Role of the chronic inflammatory mediator NO in early mammary tumorigenesis
    LESLEY ELLIES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  86. Department of Pathology LSR2 Cytometer
    Frederic Preffer; Fiscal Year: 2005
    ..The laboratory has the documented financial support of both the Department of Pathology and MGH administration. ..
  87. NEUTROPHIL HOMEOSTASIS IN LUNG INFLAMMATION
    BENJAMIN SURATT; Fiscal Year: 2005
    ..These studies will address fundamental questions of neutrophil biology as well as provide clues to the mechanisms of lung injury in bone marrow transplantation. ..
  88. Evaluation of Hypoxia by EF5 Binding in Cervix Cancer
    Sydney Evans; Fiscal Year: 2003
    ..This will allow conversion of binding to tumor pO2. Further analyses will incorporate the area of tissue involved at various binding levels. Patient follow-up and statistical evaluations will be provided by the GOG. ..
  89. Role of SV40 in Salivary Gland Tumorigenesis
    LESLEY ELLIES; Fiscal Year: 2003
    ..Analysis of molecular changes occurring during salivary gland tumorigenesis may lead to the development of therapeutic agents for the treatment of malignant disease. ..
  90. Role of airway submucosal glands in CF lung disease
    Alan S Verkman; Fiscal Year: 2010
    ..The data will provide a rigorous scientific rationale for use of small-molecules in CF therapy, and establish widely useful assays to prioritize small molecules for clinical development. ..
  91. NEURAL CIRCUITRY OF THE KIDNEY
    Mark Weiss; Fiscal Year: 2006
    ..abstract_text> ..
  92. NOVEL TYROSINASE MUTANTS AS IMAGING MARKER GENES
    Alexei Bogdanov; Fiscal Year: 2002
    ..The long-term goal of this research is to explore and develop novel and useful bifunctional "imaging/therapeutic marker genes" for in vivo use. ..
  93. Implications of Endothelial-Myocyte Uncoupling in Cardiac Arrhythmia
    Suresh C Tyagi; Fiscal Year: 2010
    ..These studies will delineate the mechanism of Hcy-dependent endothelial-myocyte uncoupling in cardiac arrhythmia and failure, and will have therapeutic ramifications for sudden cardiac death. ..
  94. PECAM-1'S INVOLVEMENT IN ANGIOGENESIS
    Horace Delisser; Fiscal Year: 2002
    ....
  95. The Role of PECAM in Models of Lung Injury
    Steven Albelda; Fiscal Year: 2005
    ..These studies will fill a gap in the basic understanding of lung and cell adhesion biology, as well as provide potentially useful therapeutic information. ..
  96. Role of VEGF in Testis Morphogenesis
    Andrea S Cupp; Fiscal Year: 2010
    ....
  97. Chemoprevention of murine urinary bladder carcinogenesis
    Ashish Kamat; Fiscal Year: 2005
    ..abstract_text> ..