HAMP

Summary

Gene Symbol: HAMP
Description: hepcidin antimicrobial peptide
Alias: HEPC, HFE2B, LEAP1, PLTR, hepcidin, liver-expressed antimicrobial peptide 1
Species: human

Top Publications

  1. ncbi IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism
    Irina Stoian
    Department of Biochemistry, Carol Davila, Faculty of Medicine, University of Medicine and Pharmacy, Bucharest, Romania
    Rom J Intern Med 45:305-9. 2007
  2. doi [Role of iron metabolism-regulator hepcidin in perinatal iron homeostasis]
    Adam Balogh
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Gyermekgyógyászati Klinika, Budapest
    Orv Hetil 151:83-91. 2010
  3. doi Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin
    Satoshi Kono
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biochim Biophys Acta 1802:968-75. 2010
  4. doi Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations
    Luca Valenti
    Centro Malattie Metaboliche del Fegato, Department of Internal Medicine, Universita degli Studi, Ospedale Maggiore Policlinico Ca Granda IRCCS, Milano, Via F Sforza 35, 20122 Milano, Italy
    Arterioscler Thromb Vasc Biol 31:683-90. 2011
  5. pmc Hepcidin and iron regulation, 10 years later
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Blood 117:4425-33. 2011
  6. doi Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload
    Donatella Barisani
    Department of Experimental Medicine, University of Milano Bicocca, Via Cadore 48, Monza 20052, Milan, Italy
    J Hepatol 49:123-33. 2008
  7. doi Divalent metal-dependent regulation of hepcidin expression by MTF-1
    Sara Balesaria
    Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom
    FEBS Lett 584:719-25. 2010
  8. ncbi Hepcidin inhibits apical iron uptake in intestinal cells
    Natalia P Mena
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Santiago, Chile
    Am J Physiol Gastrointest Liver Physiol 294:G192-8. 2008
  9. doi Elevated systemic hepcidin and iron depletion in obese premenopausal females
    Lisa M Tussing-Humphreys
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:1449-56. 2010
  10. ncbi Hepcidin, an acute-phase protein and a marker of inflammation in kidney transplant recipients with and without coronary artery disease
    J Malyszko
    Department of Nephrology and Transplantology, Bialystok Medical University, Bialystok, Poland
    Transplant Proc 38:2895-8. 2006

Research Grants

  1. Hepcidin Expression in the Anemia of Chronic Disease
    David Weinstein; Fiscal Year: 2007
  2. Jodie L Babitt; Fiscal Year: 2016
  3. Donald A McClain; Fiscal Year: 2016
  4. Hemochromatosis - Epidemiology and Molecular Mechanisms
    Pauline L Lee; Fiscal Year: 2010
  5. BMP Signaling and Iron Metabolism
    Jodie L Babitt; Fiscal Year: 2010
  6. Herbert Y Lin; Fiscal Year: 2014
  7. CAROLINE ENNS; Fiscal Year: 2016
  8. CAROLINE ENNS; Fiscal Year: 2016
  9. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
  10. Stefano Rivella; Fiscal Year: 2014

Detail Information

Publications231 found, 100 shown here

  1. ncbi IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism
    Irina Stoian
    Department of Biochemistry, Carol Davila, Faculty of Medicine, University of Medicine and Pharmacy, Bucharest, Romania
    Rom J Intern Med 45:305-9. 2007
    Recently discovered peptide hormone hepcidin is the key regulator of systemic iron homeostasis. Iron metabolism is regulated in response to variations in hepcidin plasma levels...
  2. doi [Role of iron metabolism-regulator hepcidin in perinatal iron homeostasis]
    Adam Balogh
    Semmelweis Egyetem, Általános Orvostudományi Kar, I Gyermekgyógyászati Klinika, Budapest
    Orv Hetil 151:83-91. 2010
    b>Hepcidin is a recently recognized defensin-like peptide, which is considered to be the central regulator of iron metabolism. Hepcidin decreases the expression of iron transporting molecules...
  3. doi Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin
    Satoshi Kono
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biochim Biophys Acta 1802:968-75. 2010
    ..Ferroportin is posttranslationally regulated through internalization triggered by hepcidin binding...
  4. doi Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations
    Luca Valenti
    Centro Malattie Metaboliche del Fegato, Department of Internal Medicine, Universita degli Studi, Ospedale Maggiore Policlinico Ca Granda IRCCS, Milano, Via F Sforza 35, 20122 Milano, Italy
    Arterioscler Thromb Vasc Biol 31:683-90. 2011
    Increased body iron stores and hepcidin have been hypothesized to promote atherosclerosis by inducing macrophage iron accumulation and release of cytokines, but direct demonstration in human cells is lacking...
  5. pmc Hepcidin and iron regulation, 10 years later
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Blood 117:4425-33. 2011
    ..The iron-regulatory hormone hepcidin, first described 10 years ago, and its receptor and iron channel ferroportin control the dietary absorption, ..
  6. doi Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload
    Donatella Barisani
    Department of Experimental Medicine, University of Milano Bicocca, Via Cadore 48, Monza 20052, Milan, Italy
    J Hepatol 49:123-33. 2008
    ..Since the pathophysiology of Dysmetabolic Hepatic Iron Overload (DHIO) is still obscure, the aim of this study was to evaluate, in these patients, possible alterations in iron-related molecule expression...
  7. doi Divalent metal-dependent regulation of hepcidin expression by MTF-1
    Sara Balesaria
    Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom
    FEBS Lett 584:719-25. 2010
    b>Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia...
  8. ncbi Hepcidin inhibits apical iron uptake in intestinal cells
    Natalia P Mena
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Santiago, Chile
    Am J Physiol Gastrointest Liver Physiol 294:G192-8. 2008
    b>Hepcidin (Hepc) is considered a key mediator in iron trafficking. Although the mechanism of Hepc action in macrophages is fairly well established, much less is known about its action in intestinal cells, one of the main targets of Hepc...
  9. doi Elevated systemic hepcidin and iron depletion in obese premenopausal females
    Lisa M Tussing-Humphreys
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA
    Obesity (Silver Spring) 18:1449-56. 2010
    b>Hepcidin, the body's main regulator of systemic iron homeostasis, is upregulated in response to inflammation and is thought to play a role in the manifestation of iron deficiency (ID) observed in obese populations...
  10. ncbi Hepcidin, an acute-phase protein and a marker of inflammation in kidney transplant recipients with and without coronary artery disease
    J Malyszko
    Department of Nephrology and Transplantology, Bialystok Medical University, Bialystok, Poland
    Transplant Proc 38:2895-8. 2006
    ..Iron metabolism is disturbed in chronic inflammatory diseases such as atherosclerosis. Hepcidin, the liver-expressed antimicrobial peptide, LEAP-1, is an acute-phase reactant produced in the liver that ..
  11. ncbi Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    C H Park
    Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, California 90059, USA
    J Biol Chem 276:7806-10. 2001
    ..we characterized a cysteine-rich peptide with three forms differing by amino-terminal truncation, and we named it hepcidin (Hepc) because of its origin in the liver and its antimicrobial properties...
  12. ncbi A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    C Pigeon
    INSERM U522, CHRU Pontchaillou, Rennes, France
    J Biol Chem 276:7811-9. 2001
    ..an 83-amino acid protein presenting a strong homology in its C-terminal region to the human antimicrobial peptide hepcidin. In addition, we cloned the corresponding rat and human orthologue cDNAs...
  13. ncbi Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease
    David A Weinstein
    Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 100:3776-81. 2002
    ..role of the adenomas in the pathogenesis of the anemia and found that they produce inappropriately high levels of hepcidin mRNA. Hepcidin is a peptide hormone that has been implicated in controlling the release of iron from cells...
  14. pmc Hepcidin in iron overload disorders
    George Papanikolaou
    First Department of Medicine, National and Kapodistrian University of Athens, Greece
    Blood 105:4103-5. 2005
    b>Hepcidin is the principal regulator of iron absorption in humans. The peptide inhibits cellular iron efflux by binding to the iron export channel ferroportin and inducing its internalization and degradation...
  15. ncbi Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    Duygu Dee Harrison-Findik
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5820, USA
    J Biol Chem 281:22974-82. 2006
    ..b>Hepcidin, a circulatory peptide synthesized in the liver, is a key mediator of iron metabolism...
  16. pmc Increased hepcidin expression in colorectal carcinogenesis
    Douglas G Ward
    CRUK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Birmingham B15 2TH, United Kingdom
    World J Gastroenterol 14:1339-45. 2008
    To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anaemia and whether it might have a role in colorectal carcinogenesis.
  17. doi Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantation
    Junya Kanda
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Haematologica 93:1550-4. 2008
    The relationship between serum hepcidin, a key regulator of body iron homeostasis, and erythropoiesis was investigated before and after stem cell transplantation in 31 patients with hematopoietic malignancies...
  18. doi Mass spectrometry-based proteomic analysis of urine in acute kidney injury following cardiopulmonary bypass: a nested case-control study
    Julie Ho
    Section of Nephrology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Kidney Dis 53:584-95. 2009
    ..The early evolution of acute kidney injury (AKI) in humans is difficult to study noninvasively. We hypothesized that urine proteomics could provide insight into the early pathophysiology of human AKI...
  19. doi Hepcidin regulation by innate immune and infectious stimuli
    Andrew E Armitage
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Blood 118:4129-39. 2011
    b>Hepcidin controls the levels and distribution of iron, an element whose availability can influence the outcome of infections...
  20. ncbi Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin
    Hal Drakesmith
    Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, United Kingdom
    Blood 106:1092-7. 2005
    ..The peptide hormone hepcidin inhibits FPN as part of a homeostatic negative feedback loop...
  21. ncbi LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    A Krause
    Niedersächsisches Institut für Peptid Forschung, Hannover, Germany
    FEBS Lett 480:147-50. 2000
    ..The discovery of LEAP-1 extends the known families of mammalian peptides with antimicrobial activity by its novel disulfide motif and distinct expression pattern...
  22. ncbi Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, and the West Los Angeles Veterans Administration Hospital, University of California, Los Angeles 90095, USA
    Blood 101:2461-3. 2003
    b>Hepcidin is a liver-made peptide proposed to be a central regulator of intestinal iron absorption and iron recycling by macrophages...
  23. ncbi Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
    Antonella Roetto
    Department of Clinical and Biological Sciences, University of Torino, Azienda Ospedaliera San Luigi, 10043 Orbassano, Torino, Italy
    Nat Genet 33:21-2. 2003
    Animal models indicate that the antimicrobial peptide hepcidin (HAMP; OMIM 606464) is probably a key regulator of iron absorption in mammals...
  24. ncbi Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
    Sven G Gehrke
    Department of Internal Medicine IV, University Hospital Heidelberg, Bergheimer Strasse 58, 69115 Heidelberg, Germany
    Blood 102:371-6. 2003
    Experimental data suggest the antimicrobial peptide hepcidin as a central regulator in iron homeostasis...
  25. ncbi Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    Tomas Ganz
    Department of Medicine, David Geffen School of Medicine, 10833 Le Conte Ave, CHS 37 055, University of California, Los Angeles, CA 90095 1690, USA
    Blood 102:783-8. 2003
    Human hepcidin, a 25-amino acid peptide made by hepatocytes, may be a new mediator of innate immunity and the long-sought iron-regulatory hormone. The synthesis of hepcidin is greatly stimulated by inflammation or by iron overload...
  26. ncbi Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis
    Alison T Merryweather-Clarke
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Headley Way, Oxford OX3 9DS, UK
    Hum Mol Genet 12:2241-7. 2003
    ..of C282Y heterozygotes and homozygotes may be modified by heterozygosity for mutations which disrupt the function of hepcidin in iron homeostasis, with the severity of iron overload corresponding to the severity of the HAMP mutation.
  27. ncbi HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype
    Sandrine Jacolot
    INSERM, EMI 0115, Brest, France
    Blood 103:2835-40. 2004
    ..The non-HFE hereditary hemochromatosis forms include a juvenile onset form associated with mutations in HAMP. From a cohort of 392 C282Y homozygous patients, we found 5 carriers of an additional HAMP mutation at the ..
  28. pmc IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, California, USA
    J Clin Invest 113:1271-6. 2004
    ..In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin ..
  29. ncbi Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Science 306:2090-3. 2004
    b>Hepcidin is a peptide hormone secreted by the liver in response to iron loading and inflammation. Decreased hepcidin leads to tissue iron overload, whereas hepcidin overproduction leads to hypoferremia and the anemia of inflammation...
  30. ncbi Anemia of inflammation: the hepcidin link
    Cindy N Roy
    Children s Hospital, Boston, MA 02115, USA
    Curr Opin Hematol 12:107-11. 2005
    ..Recently hepcidin antimicrobial peptide has emerged as the hormone that links the type II acute phase response to iron handling and ..
  31. ncbi Hepcidin and iron-loading anemias
    Elizabeta Nemeth
    Haematologica 91:727-32. 2006
  32. pmc Interleukin-6 induces hepcidin expression through STAT3
    Diedra M Wrighting
    Graduate Program in Biological and Biomedical Sciences, Harvard University, Boston, MA, USA
    Blood 108:3204-9. 2006
    Iron homeostasis is maintained through meticulous regulation of circulating hepcidin levels. Hepcidin levels that are inappropriately low or high result in iron overload or iron deficiency, respectively...
  33. ncbi STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
    Maria Vittoria Verga Falzacappa
    Molecular Medicine Partnership Unit, University of Heidelberg, Heidelberg, Germany
    Blood 109:353-8. 2007
    b>Hepcidin is a key iron-regulatory hormone produced by the liver...
  34. ncbi Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH
    Soumeya Bekri
    Laboratoire d Hépato Gastroentérologie, EA1186, Faculté Médecine de Nice, Nice, France
    Gastroenterology 131:788-96. 2006
    b>Hepcidin is an acute-phase response peptide. We have investigated the possible involvement of hepcidin in massive obesity, a state of chronic low-grade inflammation...
  35. ncbi Hepcidin is down-regulated in alcohol loading
    Takaaki Ohtake
    Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa 078 8510, Japan
    Alcohol Clin Exp Res 31:S2-8. 2007
    ..However, the mechanism of hepatic iron uptake in ALD is still obscure. Recently, a novel iron-regulatory hormone hepcidin was found that suppresses the absorption of iron from the small intestine and the release of iron from ..
  36. ncbi High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
    Toshihiko Tanno
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 13:1096-101. 2007
    ..in the absence of blood transfusions may result from inappropriate suppression of the iron-regulating peptide hepcidin by an erythropoietic mechanism...
  37. ncbi Elevated basal hepcidin levels in the liver may inhibit the development of malaria infection: another piece towards solving the malaria puzzle?
    Albert Oliveras-Vergés
    Department of Signal Theory and Communications, Technical University of Catalonia UPC, Jordi Girona 1 3, 08034 Barcelona, Spain
    Med Hypotheses 70:630-4. 2008
    ..IL-6 controls systemic iron homeostasis through hepcidin, which is produced mainly by hepatocytes...
  38. pmc Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin
    Erika V Valore
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1690, USA
    Blood Cells Mol Dis 40:132-8. 2008
    b>Hepcidin is encoded as an 84 amino acid prepropeptide containing a typical N-terminal 24 amino acid endoplasmic reticulum targeting signal sequence, and a 35 amino acid proregion (pro) with a consensus furin cleavage site immediately ..
  39. ncbi Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells
    Bomee Chung
    Nutritional Sciences Division, King s College London, London SE1 9NH, UK
    J Nutr 137:2366-70. 2007
    ..of chronic disease via its stimulatory actions on the production and release of the iron regulatory hormone hepcidin. To test this hypothesis, we exposed HuH7 human hepatoma cells to leptin and measured hepcidin mRNA expression by ..
  40. ncbi Regulation of hepcidin: insights from biochemical analyses on human serum samples
    Erwin H J M Kemna
    Department of Clinical Chemistry 441, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood Cells Mol Dis 40:339-46. 2008
    Knowledge of hepcidin regulation is foremost gained by in vitro studies. We aimed to translate this knowledge into the human in vivo situation...
  41. doi A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells
    Maria Vittoria Verga Falzacappa
    Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    J Mol Med (Berl) 86:531-40. 2008
    The precise regulation of the iron-regulatory hormone hepcidin is essential to maintain body iron homeostasis: Hepcidin deficiency induces iron overload, and hepcidin excess results in anaemia...
  42. pmc Expression of hepcidin mRNA is uniformly suppressed in hepatocellular carcinoma
    Hiroaki Kijima
    Second Department of Surgery, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    BMC Cancer 8:167. 2008
    The present study evaluated the expression of hepcidin mRNA in hepatocellular carcinoma (HCC).
  43. doi Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity
    Kouichi Miura
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Hepatology 48:1420-9. 2008
    ..However, the mechanism by which hepatitis C virus (HCV) regulates iron metabolism is poorly understood. Hepcidin plays a pivotal role as a negative regulator of iron absorption...
  44. doi Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection
    Quirijn de Mast
    Department of General Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 199:253-62. 2009
    ..explanation for observed alterations in iron distribution, we studied the course of the iron regulatory hormone hepcidin in anemic Tanzanian children with febrile Plasmodium falciparum malaria...
  45. pmc Investigation of the biophysical and cell biological properties of ferroportin, a multipass integral membrane protein iron exporter
    Adrian E Rice
    Graduate Option in Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, CA 91125, USA
    J Mol Biol 386:717-32. 2009
    ..Ferroportin-mediated iron export is controlled by the hormone hepcidin, which binds ferroportin, causing its internalization and degradation...
  46. pmc Iron in innate immunity: starve the invaders
    Tomas Ganz
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, United States
    Curr Opin Immunol 21:63-7. 2009
    ..Specialized inflammation-regulated proteins chelate iron, trap siderophores, and transport iron or modulate its transport to alter its tissue distribution during infections...
  47. pmc BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    Billy Andriopoulos
    Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Nat Genet 41:482-7. 2009
    ..is an iron-overload disorder caused by mutations in the genes encoding the major iron regulatory hormone hepcidin (HAMP) and hemojuvelin (HFE2)...
  48. pmc Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
    Junwei Gao
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Cell Metab 9:217-27. 2009
    ..They have lower levels of hepcidin than unaffected individuals...
  49. pmc Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells
    Toshihiko Tanno
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 114:181-6. 2009
    ..molecules are thought to cause inappropriate suppression of a small peptide produced by hepatocytes named hepcidin. Previously, it was reported that the erythrokine GDF15 is expressed at very high levels in thalassemia and ..
  50. doi Activation and inactivation of the iron hormone hepcidin: Biochemical characterization of prohepcidin cleavage and sequential degradation to N-terminally truncated hepcidin isoforms
    Melanie Schranz
    Medical University of Innsbruck, Department of Medicine II Gastroenterology and Hepatology, Austria
    Blood Cells Mol Dis 43:169-79. 2009
    The hormone hepcidin is produced mainly in the liver in response to iron loading and inflammation and secreted into the circulation as a 25-amino acid peptide...
  51. pmc HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients
    Luca Valenti
    Center for Metabolic and Liver Diseases, Department of Internal Medicine, Universita degli Studi di Milano, Fondazione Ospedale Maggiore Policlinico MaRE IRCCS, Via F Sforza 35, 20122 Milano, Italy
    Clin J Am Soc Nephrol 4:1331-7. 2009
    Increased serum hepcidin has been reported in patients receiving chronic hemodialysis, and hypothesized to contribute to the alterations of iron metabolism of end-stage renal disease...
  52. pmc Hepcidin revisited, disulfide connectivity, dynamics, and structure
    John B Jordan
    Department of Molecular Structure, Amgen, Inc, Thousand Oaks, California 91320, USA
    J Biol Chem 284:24155-67. 2009
    b>Hepcidin is a tightly folded 25-residue peptide hormone containing four disulfide bonds, which has been shown to act as the principal regulator of iron homeostasis in vertebrates...
  53. doi Cholestasis downregulate hepcidin expression through inhibiting IL-6-induced phosphorylation of signal transducer and activator of transcription 3 signaling
    Ying Hsien Huang
    Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC
    Lab Invest 89:1128-39. 2009
    b>Hepcidin is downregulated during progressive cholestasis in biliary atresia, but the mechanism is unknown...
  54. ncbi Hepcidin expression in adipose tissue increases during cardiac surgery
    M Vokurka
    Institute of Pathological Physiology, Center of Experimental Hematology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Physiol Res 59:393-400. 2010
    b>Hepcidin, a key regulator of iron metabolism, plays a crucial role in the pathogenesis of anemia of chronic disease...
  55. pmc Reduced serum hepcidin levels in patients with chronic hepatitis C
    Domenico Girelli
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, Verona, Italy
    J Hepatol 51:845-52. 2009
    ..The hepatic hormone hepcidin is the major regulator of iron metabolism and inhibits iron absorption and recycling from erythrophagocytosis...
  56. doi Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency
    Emanuele Miraglia del Giudice
    Department of Pediatrics F Fede Seconda Università degli Studi di Napoli, Napoli, Italy
    J Clin Endocrinol Metab 94:5102-7. 2009
    ..Several studies found higher rates of iron deficiency in obese than in normal-weight children. Hepcidin represents the main inhibitor of intestinal iron absorption, and its expression is increased in adipose tissue of ..
  57. pmc The role of hepcidin in iron metabolism
    Elizabeta Nemeth
    David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Acta Haematol 122:78-86. 2009
    b>Hepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders...
  58. pmc Reduction of serum hepcidin by hemodialysis in pediatric and adult patients
    Joshua Zaritsky
    Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Clin J Am Soc Nephrol 5:1010-4. 2010
    b>Hepcidin, the principal regulator of iron homeostasis, may play a critical role in the response of patients with anemia to iron and erythropoiesis-stimulating agent therapy; however, the contribution of hepcidin to iron maldistribution ..
  59. pmc Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis
    Eric Bachman
    Department of Medicine, Boston University School of Medicine, 670 Albany Street, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:4743-7. 2010
    ..The mechanisms by which testosterone increases hemoglobin and hematocrit are unknown...
  60. pmc Hepcidin expression by human monocytes in response to adhesion and pro-inflammatory cytokines
    Xiaolan Zhang
    Department of Internal Medicine, Ohio State University, Columbus, OH, USA
    Biochim Biophys Acta 1800:1262-7. 2010
    A previous urine proteomic analysis from our laboratory suggested that hepcidin may be a biomarker for lupus nephritis flare...
  61. pmc Serum prohepcidin levels in chronic hepatitis C, alcoholic liver disease, and nonalcoholic fatty liver disease
    Sang Hyub Lee
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
    Korean J Hepatol 16:288-94. 2010
    ..Prohepcidin is an easily measurable precursor of hepcidin, which is a key regulator of iron homeostasis...
  62. doi The effect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exercise
    Paula Robson-Ansley
    Department of Sport and Exercise Science, Northumbria University, Newcastle, UK
    Cytokine 53:196-200. 2011
    The aim of our study was twofold, firstly to examine the relationship between plasma concentrations of IL-6, hepcidin and iron following prolonged exercise and secondly, to assess the effect of carbohydrate ingestion on circulating ..
  63. pmc Hepcidin induces HIV-1 transcription inhibited by ferroportin
    Min Xu
    Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC 20060, USA
    Retrovirology 7:104. 2010
    ..by the membrane protein, ferroportin, the expression of which is induced by iron and negatively modulated by hepcidin. We previously showed that iron chelation is associated with decreased HIV-1 transcription...
  64. doi Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project
    Alberto Piperno
    Department of Clinical Medicine and Prevention, University of Milano Bicocca and S Gerardo Hospital, Monza, Italy
    Blood 117:2953-9. 2011
    ..in hematocrit, serum iron indices, erythropoietin, markers of erythropoietic activity, interleukin-6, and serum hepcidin. Hepcidin decreased within 40 hours after acute hypoxia exposure (P < ...
  65. doi Role of decreased circulating hepcidin concentrations in the iron excess of women with the polycystic ovary syndrome
    Manuel Luque-Ramírez
    Department of Endocrinology, Hospital Universitario Ramon y Cajal and Universidad de Alcala, Carretera de Colmenar Viejo km 9 1, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 96:846-52. 2011
    b>Hepcidin inhibits the intestinal absorption of iron and its deficiency causes juvenile hemochromatosis.
  66. pmc Hepcidin is an antibacterial, stress-inducible peptide of the biliary system
    Pavel Strnad
    Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany
    PLoS ONE 6:e16454. 2011
    b>Hepcidin (gene name HAMP), an IL-6-inducible acute phase peptide with antimicrobial properties, is the key negative regulator of iron metabolism...
  67. doi Modulation of hepatitis C virus replication by iron and hepcidin in Huh7 hepatocytes
    Giody Bartolomei
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    J Gen Virol 92:2072-81. 2011
    ..We also found that RNAi-mediated knockdown of the key Fe modulator hepcidin increased intracellular ferritin and inhibited HCV replication...
  68. pmc Urinary hepcidin-25 and risk of acute kidney injury following cardiopulmonary bypass
    Julie Ho
    Sections of Nephrology and Biomedical Proteomics, Health Sciences Centre, GE421C, 820 Sherbrooke Street, Winnipeg, Manitoba, MB R3A 1R9, Canada
    Clin J Am Soc Nephrol 6:2340-6. 2011
    ..Urinary hepcidin-25 has been shown to be elevated in patients who do not develop AKI after CPB using semiquantitative mass ..
  69. pmc Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
    Andrew M Prentice
    Medical Research Council International Nutrition Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Blood 119:1922-8. 2012
    ..We investigated how the iron-regulatory hormone hepcidin and other inflammatory/iron-related indices, all measured on the day of isotope administration, correlated with ..
  70. ncbi The effects of 8 weeks of endurance running on hepcidin concentrations, inflammatory parameters, and iron status in female runners
    Irena Auersperger
    Faculty of Sport, University of Ljubljana, Ljubljana, Slovenia
    Int J Sport Nutr Exerc Metab 22:55-63. 2012
    ..The authors investigated the effects of long-term endurance exercise on hepcidin concentrations, inflammatory parameters, and iron status in moderately trained female long-distance runners...
  71. doi Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating serum hepcidin levels in Rwandese HIV-positive women
    Florence Masaisa
    Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University, Belgium
    Ann Hematol 91:911-6. 2012
    ..This mutation has been associated with resistance to hepcidin and therefore we hypothesized that iron-related parameters and the prevalence of opportunistic infections in HIV ..
  72. doi Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT
    Sandra L Ross
    Department of Oncology, Amgen Inc, Thousand Oaks, CA 91320, USA
    Cell Metab 15:905-17. 2012
    Ferroportin is the primary means of cellular iron efflux and a key component of iron metabolism. Hepcidin regulates Fpn activity by inducing its internalization and degradation...
  73. pmc Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination
    Bo Qiao
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 15:918-24. 2012
    ..The hormone hepcidin controls cellular iron export and plasma iron concentrations by binding to ferroportin and causing its ..
  74. doi Interleukin-6 and lipopolysaccharide modulate hepcidin mRNA expression by HepG2 cells
    Pía Villarroel
    Micronutrient Laboratory, INTA, University of Chile, El Libano 5524, Macul, Santiago, Chile, 138 11
    Biol Trace Elem Res 150:496-501. 2012
    Iron homeostasis is controlled by hepcidin (Hpc) as well as other ways. Hpc expression is regulated by iron (Fe) storage and by inflammation, but the joint effect of both stimuli remains unclear...
  75. doi Circulatory hepcidin is associated with the anti-inflammatory response but not with iron or anemic status in childhood malaria
    Florence Burté
    Division of Parasitology, Medical Research Council National Institute for Medical Research, London, UK
    Blood 121:3016-22. 2013
    ..Increased levels of hepcidin have been associated with UM, but its level and role in severe malarial disease remains to be investigated...
  76. pmc Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya
    Tanja Jaeggi
    Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland
    PLoS ONE 8:e57513. 2013
    b>Hepcidin regulation by competing stimuli such as infection and iron deficiency has not been studied in infants and it's yet unknown whether hepcidin regulatory pathways are fully functional in infants...
  77. pmc Cellular catabolism of the iron-regulatory peptide hormone hepcidin
    Gloria Cuevas Preza
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e58934. 2013
    b>Hepcidin, a 25-amino acid peptide hormone, is the principal regulator of plasma iron concentrations...
  78. ncbi Serum hepcidin-20 is elevated during the acute phase of myocardial infarction
    Hiroshi Suzuki
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Tohoku J Exp Med 218:93-8. 2009
    b>Hepcidin, a key iron-regulator secreted from the liver, consists of 25 amino acids (hepcidin-25), blocks iron release from macrophages via internalization and degradation of cellular iron exporter ferroportin, and restrains the use of ..
  79. doi Serum pro-hepcidin levels in rheumatoid arthritis and systemic lupus erythematosus
    Suleyman Serdar Koca
    Department of Rheumatology, Faculty of Medicine, Firat University, Elazig, Turkey
    Inflammation 31:146-53. 2008
    b>Hepcidin is a principal iron regulatory hormone and its expression is stimulated by cytokines...
  80. pmc Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia major
    Marco Andreani
    Laboratorio di Immunogenetica e Biologia dei Trapianti, Fondazione IME, Policlinico Tor Vergata, Viale Oxford 81, Rome, Italy
    Haematologica 94:1293-6. 2009
    b>Hepcidin is a 25-amino acid peptide, derived from cleavage of an 84 amino acid pro-peptide produced predominantly by hepatocytes...
  81. ncbi Macrophage iron, hepcidin, and atherosclerotic plaque stability
    Jerome L Sullivan
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, College of Medicine, Gainesville, Florida 32610, USA
    Exp Biol Med (Maywood) 232:1014-20. 2007
    b>Hepcidin has emerged as the key hormone in the regulation of iron balance and recycling. Elevated levels increase iron in macrophages and inhibit gastrointestinal iron uptake...
  82. doi Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery
    Lisa M Tussing-Humphreys
    United States Department of Agriculture Agricultural Research Service, Southern Regional Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 18:2010-6. 2010
    ..is thought to be mediated by an inflammation-induced increase in the body's main regulator of iron homeostasis, hepcidin. Elevated hepcidin can result in iron depletion as it prevents the release of dietary iron absorbed into the ..
  83. ncbi [The effect of tobacco smoking during pregnancy on concentration of pro-hepcidin and some parameters of iron metabolism in matched-maternal cord pairs]
    Magdalena Chełchowska
    Zakład Badań Przesiewowych, Instytut Matki i Dziecka w Warszawie
    Przegl Lek 65:474-8. 2008
    Iron deficiency relatively observed in pregnant women is assumed to be enhanced by cigarette smoking. Hepcidin, a peptide hormone produced by the liver as pro-hepcidin, has recently emerged as a central mediator of iron metabolism...
  84. pmc Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
    Emilio Ramos
    Chemistry and Biochemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Hepatology 53:1333-41. 2011
    In response to iron loading, hepcidin synthesis is homeostatically increased to limit further absorption of dietary iron and its release from stores...
  85. doi The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes
    Xiao Hu Ge
    National Key Laboratory of Chinese Medicine and Molecular Pharmacology Shenzhen and Laboratory of Brain Iron Metabolism, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong
    J Nutr Biochem 20:860-5. 2009
    ..The presence of hepcidin, a recently discovered iron regulatory hormone, was also confirmed in the heart recently...
  86. ncbi [Molecular mechanisms of iron homeostasis]
    Carole Beaumont
    INSERM U 409, Faculte de Medecine Xavier Bichat, BP 416, 16, rue Henri Huchard, 75870 Paris 18, France
    Med Sci (Paris) 20:68-72. 2004
    ..hephaestin or ceruloplasmin) or ferri-reductase (Dcytb) activity or regulatory proteins like HFE and hepcidin. Furthermore, a new transferrin receptor has been identified, mostly expressed in the liver, and the ability of ..
  87. pmc Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
    Gael Nicolas
    Département de génétique, Developpement et Pathologie Moleculaire, Institut Cochin, Centre National de la Recherche Scientifique, et Université René Descartes, Faculté de Médecine Cochin Port Royal, 75014 Paris, France
    Proc Natl Acad Sci U S A 99:4596-601. 2002
    ..trait could be attributed to the absence, in the Usf2 knockout mice, of a secreted liver-specific peptide, hepcidin. We conjectured that the reverse situation, namely overexpression of hepcidin, might result in phenotypic traits ..
  88. doi Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis
    Claudia Bozzini
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    Blood Cells Mol Dis 40:347-52. 2008
    Insufficient production of hepcidin, the master regulator of iron metabolism, is recognized as the key pathogenetic feature of HFE-related hereditary hemochromatosis (HH)...
  89. doi Mass spectrometry measurement of plasma hepcidin for the prediction of iron overload
    Annarosa Floreani
    Department of Surgical and Gastroenterological Sciences, University of Padova, Padova, Italy
    Clin Chem Lab Med 49:197-206. 2011
    b>Hepcidin has emerged as the primary regulator of iron homeostasis. Previous studies on assessing urinary hepcidin are limited...
  90. pmc Is serum hepcidin causative in hemochromatosis? Novel analysis from a liver transplant with hemochromatosis
    Paul C Adams
    Department of Medicine, University of Western Ontario, London, Ontario
    Can J Gastroenterol 22:851-3. 2008
    b>Hepcidin is a circulating hepatic hormone that regulates iron balance. It has been speculated that hepcidin insufficiency or dysregulation may be the primary defect in genetic hemochromatosis.
  91. pmc A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis
    Domenico Girelli
    Department of Medicine, University of Verona, Policlinico GB Rossi, 37134 Verona, Italy
    Haematologica 96:500-6. 2011
    Inadequate hepcidin production leads to iron overload in nearly all types of hemochromatosis...
  92. ncbi Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis
    Alberto Piperno
    Department of Clinical Medicine and Prevention, Milano Bicocca University, San Gerardo Hospital, Monza, Italy
    Blood 110:4096-100. 2007
    Inadequate hepcidin synthesis leads to iron overload in HFE-related hemochromatosis...
  93. pmc Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis
    Elena Corradini
    Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 137:1489-97. 2009
    ..Levels of the main iron regulatory hormone, hepcidin, are inappropriately low in hereditary hemochromatosis mouse models and patients with HFE mutations, indicating ..
  94. doi Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis
    John D Ryan
    Centre for Liver Disease, Mater Misericordiae University Hospital, Dublin, Ireland
    Hepatology 52:1266-73. 2010
    ..The vast majority of patients carry the missense Cys282Tyr mutation of the HFE gene. Hepcidin, the central regulator of iron homeostasis, is deficient in HH, leading to unchecked iron absorption and ..
  95. pmc Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
    Sara Gardenghi
    Weill Cornell Medical College, New York, New York, USA
    J Clin Invest 120:4466-77. 2010
    ..Iron overload is associated with low levels of hepcidin, a peptide that regulates iron metabolism by triggering degradation of ferroportin, an iron-transport protein ..
  96. pmc Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    G Nicolas
    Institut National de la Santé et de la Recherche Médicale 129, Departement Genetique Developpement et Pathologie Moléculaire, Institut Cochin de Genetique Moleculaire, Faculté de Médecine Cochin Port Royal, 75014 Paris, France
    Proc Natl Acad Sci U S A 98:8780-5. 2001
    ..We isolated a cDNA encoding a peptide, hepcidin (also referred to as LEAP-1, for liver-expressed antimicrobial peptide), that was very recently purified from ..
  97. pmc Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
    Lan Lin
    Departments of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Blood 110:2182-9. 2007
    The peptide hormone hepcidin is the principal regulator of systemic iron homeostasis. We examined the pathway by which iron stimulates the production of hepcidin...
  98. ncbi Three different hepcidins from tilapia, Oreochromis mossambicus: analysis of their expressions and biological functions
    Pao Hsian Huang
    Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, 23 10 Dahuen Road, Jiaushi, Ilan 262, Taiwan, ROC
    Mol Immunol 44:1922-34. 2007
    ..Through hybridization of a phage library, the cDNA sequences of three hepcidin-like antimicrobial peptides (named TH1-5, TH2-2, and TH2-3) in tilapia, Oreochromis mossambicus, were determined...
  99. doi Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
    Daniel F Wallace
    Membrane Transport Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hepatology 50:1992-2000. 2009
    b>Hepcidin is a central regulator of iron homeostasis. HFE and transferrin receptor 2 (TFR2) are mutated in adult-onset forms of hereditary hemochromatosis and regulate the expression of hepcidin in response to iron...
  100. pmc Transferrin receptor 2 is crucial for iron sensing in human hepatocytes
    Chiara Rapisarda
    King s College London, UK
    Am J Physiol Gastrointest Liver Physiol 299:G778-83. 2010
    b>Hepcidin expression in vivo is regulated in proportion to iron status (i.e., increased by iron loading and decreased in iron deficiency)...

Research Grants65

  1. Hepcidin Expression in the Anemia of Chronic Disease
    David Weinstein; Fiscal Year: 2007
    The pathogenesis of the anemia of chronic disease is not understood. A recently identified peptide, hepcidin, has been found to be aberrantly expressed in hepatic adenomas in GSD (GSD), resulting in an iron-resistant iron-deficiency ..
  2. Jodie L Babitt; Fiscal Year: 2016
    ..pathway plays an important role in systemic iron balance by modulating expression of the iron regulatory hormone hepcidin. A soluble protein secreted by the liver, hepcidin acts by downregulating the cell- surface expression of the ..
  3. Donald A McClain; Fiscal Year: 2016
    ..These include: (1) Glucose regulation of hepcidin, the main regulator of systemic iron absorption and disposition, and (2) variation of circadian metabolic ..
  4. Hemochromatosis - Epidemiology and Molecular Mechanisms
    Pauline L Lee; Fiscal Year: 2010
    ..The major regulator of iron homeostasis is the 25 amino acid peptide hepcidin. Hemochromatosis caused by genetic mutations in HFE, TfR2 and HJV is due primarily to dysregulation of hepcidin ..
  5. BMP Signaling and Iron Metabolism
    Jodie L Babitt; Fiscal Year: 2010
    ..Although the function of HJV is unknown, hepcidin levels are depressed in persons with HJV mutations, suggesting that HJV positively regulates hepcidin expression...
  6. Herbert Y Lin; Fiscal Year: 2014
    ..The master regulator of overall iron balance is hepcidin, a key hormone secreted by the liver in response to several stimuli including systemic iron levels...
  7. CAROLINE ENNS; Fiscal Year: 2016
    ..It lowers iron uptake into the body, globally, by increasing the transcription of hepcidin, a hormone that negatively regulates iron efflux out of intestinal epithelial cells into the blood...
  8. CAROLINE ENNS; Fiscal Year: 2016
    ..TfR2-HFE complex provides a sensing mechanism to detect iron-loaded Tf and thereby regulates the transcription of hepcidin, a peptide hormone that negatively regulates the efflux of iron out of intestinal cells and macrophages...
  9. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
    ..The proposal involves the application of a novel assay for the iron metabolism hormone hepcidin in the approach to prevent, diagnose, and treat iron deficiency in infants...
  10. Stefano Rivella; Fiscal Year: 2014
    ..b>Hepcidin deficiency is the direct cause of iron overload in nearly all cases of hereditary hemochromatosis and in ?-..
  11. Hematopoietic Cell Transplantation and Iron Overload
    H Joachim Deeg; Fiscal Year: 2013
    ..indicate that transplantation of allogeneic (but not syngeneic) T lymphocytes results in altered expression of hepcidin and ferroportin 1, and dysregulation of iron homeostasis...
  12. Frank M Torti; Fiscal Year: 2016
    ..It is regulated by the peptide hormone hepcidin, which is made by the liver and circulates systemically...
  13. Identification of Novel Genes That Modulate Systemic Iron Homeostasis
    KARIN ELISABETH FINBERG; Fiscal Year: 2013
    ..b>Hepcidin, a small, circulating peptide produced by the liver, is a key regulator of iron homeostasis that decreases ..
  14. PAULA GOODMAN FRAENKEL; Fiscal Year: 2015
    ..Both thalassemia and hereditary hemochromatosis are associated with inappropriately low levels of hepcidin, the key regulator of intestinal iron absorption and cellular iron storage, resulting in excessive dietary iron ..
  15. Retinal Iron Homeostasis in Health and Disease
    Vadivel Ganapathy; Fiscal Year: 2013
    ..The remaining cases arise from mutations in four other genes (hemojuvelin, hepcidin, transferrin receptor 2, and ferroportin), also coding for iron-regulatory proteins...
  16. Tomas Ganz; Fiscal Year: 2016
    ..Studies by our lab and others indicate that hepcidin is suppressed by factor(s) secreted by the bone marrow in response to erythropoietic stimulation, which then act ..
  17. Hepcidin Replacement Therapy for Iron Overload Disorders
    James W Larrick; Fiscal Year: 2013
    ..Most types of iron overload are associated with low levels of hepcidin, a peptide that regulates iron metabolism by triggering degradation of ferroportin, an iron-transport protein ..
  18. Bioiron 2011: From basic science to medicine
    Tomas Ganz; Fiscal Year: 2011
    ..in our understanding of molecular iron sensing, intracellular iron transport, iron regulation including by hepcidin, ferroportin and microRNAs, pathogenesis of iron overload in iron-loading anemias, genetics of hereditary ..
  19. DERMATOREMEDIATION OF IRON OVERLOAD
    Leonard M Milstone; Fiscal Year: 2010
    ..by characterizing expression and function of iron export protein ferroportin in epidermis; 2. by using hepcidin to regulate expression of ferroportin; B...
  20. BOBBY JOSEPH CHERAYIL; Fiscal Year: 2016
    ..as well as Hfe KO mice, have abnormally low circulating levels of the hepatocyte-derived, iron-regulatory peptide hepcidin. As a result, there is a reduction of intra-macrophage iron concentrations accompanied by elevation of serum iron,..
  21. Serum Biomarkers Associated With Phenotypic Expression of Hemochromatosis.
    Kris Kowdley; Fiscal Year: 2013
    ..miRNA miR-122 was recently shown to be involved in mammalian iron homeostasis by repressing the expression of hepcidin and its activators, the Hfe and Hjv genes in a mouse model of hemochromatosis...
  22. Regulation of mammalian iron homeostasis by iron and transferrin
    THOMAS BENEDICT BARTNIKAS; Fiscal Year: 2010
    ..Fe homeostasis is largely regulated by hepcidin, a liver-derived peptide that inhibits dietary Fe absorption and macrophage Fe recycling...
  23. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012
    ..We have demonstrated that alcohol-induced oxidative stress down-regulates hepcidin transcription without causing changes in liver histology or an increase in triglycerides...
  24. Yelena Ginzburg; Fiscal Year: 2015
    ..erythropoiesis;iron overload in this disease results from transfusion and increased iron absorption from hepcidin deficiency...
  25. Genes that modify Iron loading in mice
    Nancy Catherine Andrews; Fiscal Year: 2012
    ..in iron homeostasis using mice lacking Tmprss6, a key inhibitor of production of the iron regulatory hormone hepcidin. These complementary approaches should enhance our understanding of iron homeostasis and, importantly, yield new ..
  26. JOHN DEARBORN PHILLIPS; Fiscal Year: 2014
    ..determine how iron leads to transcriptional activation and repression and determined the mechanism and consequences of the peptide hormone hepcidin as a transcriptional regulator of genes required for iron acquisition and distribution.
  27. Jerry Kaplan; Fiscal Year: 2014
    ..Systemic iron physiology is regulated by the binding of the peptide hormone hepcidin to Fpn leading to Fpn internalization and degradation...
  28. Stefano Rivella; Fiscal Year: 2015
    ..In particular, the hepatic hormone hepcidin has been identified as a central regulator of iron absorption and distribution...
  29. Modulation of Iron Deposition in SCD and Other Hemoglobinopathies
    ELLIOTT P contact VICHINSKY; Fiscal Year: 2010
    ..In particular, this project will explore the hypothesis that a chronic inflammatory state in SCD leads to hepcidin and cytokine mediated iron withholding within the RES, lower plasma NTBI levels and consequently reduced ..
  30. Mechanistic Characterization and Genetic Analysis of Systemic Iron Homeostasis
    Xin Du; Fiscal Year: 2011
    ..Specifically: 1. the normal function of TMPRSS6 is to inhibit the expression of hepcidin, the central regulator of iron homeostasis;2...
  31. Iron Acquisition by Mycobacterium tuberculosis Within Phagocytes
    Bradley E Britigan; Fiscal Year: 2013
    ..Whether other factors that regulate macrophage Fe metabolism (e.g. ferroportin, heme oxygenase 1 (HO-1), hepcidin) impact M.tb Fe acquisition is unknown. Similarly unknown is whether Fe acquisition by M...
  32. THOMAS BENEDICT BARTNIKAS; Fiscal Year: 2015
    ..Fe homeostasis is regulated by hepcidin, a largely liver-derived peptide that inhibits dietary Fe absorption and macrophage Fe recycling...
  33. Hepcidin and the pathogenesis of anemia in older adults.
    Richard D Semba; Fiscal Year: 2010
    ..b>Hepcidin, a recently discovered peptide hormone, may be a major modulator in the anemia of inflammation...
  34. Regulation of hepcidin and iron metabolism in liver disease
    Julia Goodnough; Fiscal Year: 2011
    ..Systemic iron metabolism is regulated by the peptide hormone hepcidin, which is expressed in the liver...
  35. Robert T Means; Fiscal Year: 2014
    ..b>Hepcidin is an antibacterial protein which is produced in the liver, circulates in the blood, and is excreted in the urine...
  36. Iron and malaria: the central role of hepciden and macarophage function
    ANDRE ANDRE VAN DER VEN; Fiscal Year: 2010
    The past decade has seen remarkable advances in our understanding of iron homeostasis, e.g. the discovery of hepcidin and other iron regulatory proteins, which may help to unravel the underlying mechanisms of the complex interaction ..
  37. The Hepcidin-Ferroportin Axis in Anemia of Inflammation: Mechanisms and Targets
    Elizabeta Nemeth; Fiscal Year: 2012
    ..The significance and timeliness of this area was recognized by a recent RFA (PAS-08-019). Hepcidin is the key regulator of systemic iron homeostasis and an acute phase reactant...
  38. MEREDITH ANN ATKINSON; Fiscal Year: 2015
    ..b>Hepcidin, an anti-microbial peptide produced by the liver, whose production is stimulated by inflammation, interferes with ..
  39. LAURA MARIE BYSTROM; Fiscal Year: 2014
    ..The iron biomarkers, hepcidin, ferroportin, transferrin receptor and the inflammatory cytokines, IL-1alpha and IL-6 are of particular interest ..
  40. Dana M McTigue; Fiscal Year: 2016
    ..Also, expression of two key proteins, hepcidin and ferroportin (FP), is disproportionately regulated after SCI, most notably in mice with deficient TLR4 ..
  41. TARGETING BMP SIGNALING WITH TP-0413
    PH D WARNER; Fiscal Year: 2012
    ..Anemia of cancer is cytokine driven and results in the up-regulation of a liver hormone called hepcidin through the function of BMP receptors...
  42. Marianne Wessling-Resnick; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): We advance the hypothesis that hepcidin regulates manganese metabolism...
  43. Randall T Peterson; Fiscal Year: 2016
    ..most often caused by an increased expression of inflammatory cytokines leading to maladaptive over-expression of hepcidin, a peptide hormone and critical regulator of systemic iron balance...
  44. Acute vs. delayed iron therapy: effect on iron status, anemia and cognition
    Chandy C John; Fiscal Year: 2013
    ..iron status (ZnPP, ferritin, TfR), erythropoiesis (erythropoietin, reticulocyte count) and inflammation (hepcidin, ferritin, alphal-acid glycoprotein, cytokines) will then be measured at baseline and 1, 6 and 12 months later ..
  45. Mechanisms of anemia of chronic inflammation and aging in mice.
    CINDY NORENE ROY; Fiscal Year: 2013
    ..b>Hepcidin antimicrobial peptide (Hepc) has been implicated in the pathogenesis of AICD because it is a negative regulator ..
  46. MIGUEL MAURICIO CABADA; Fiscal Year: 2016
    ..of anemia will include iron studies and markers of inflammation (including a newly described marker called hepcidin that play a key role in anemia of chronic disease)...
  47. Map Kinase Pathways and Anemia in the Elderly
    Leonidas C Platanias; Fiscal Year: 2010
    ..of the effects of the pro-inflammatory cytokine tumor necrosis factor a (TNFa) and the iron-regulatory hormone hepcidin on normal erythropoiesis...
  48. Iron and Atherosclerosis
    Subha V Raman; Fiscal Year: 2013
    ..to investigate iron in CVD arises from recent evidence identifying the effects of inflammation and iron on hepcidin, the key regulator of macrophage iron uptake and release...
  49. Functional Testing of Conserved Regions in Eukaryotic Divalent Metal Transporters
    Lisa Ann Lambert; Fiscal Year: 2012
    ..The results may provide key pieces of information (i.e., hepcidin interactions and small molecule inhibition of Nramp2) toward a better understanding of iron transport and ..
  50. Mechanisms of neurodegeneration and brain iron accumulation
    Zhongmin Alex Ma; Fiscal Year: 2010
    ..We have identified that hepcidin, a hormone regula ing iron export, is activated by inhibition of iPL~ in a p53 dependent manner...
  51. The role of iron in atherosclerosis: application of new iron biology
    Elizabeta Nemeth; Fiscal Year: 2012
    ..diseases, systemic and local inflammation increases the production of the iron-regulatory peptide hormone hepcidin. Hepcidin functions by inhibiting the release of iron from macrophages, and would have the same effect in the ..
  52. Malaria and the safety of iron interventions: absorption and NTBI
    Gary M Brittenham; Fiscal Year: 2012
    ..of the appearance of plasma non-transferrin-bound Iron (NTBI) and measurements of the iron reguliatory hormone, hepcidin, and other proteins of iron metabolism...
  53. MARK EDWARD WESTERMAN; Fiscal Year: 2016
    ..The peptide hormone hepcidin has emerged as the master regulator of iron metabolism...
  54. PORPHYRIN BIOSYNTHESIS IN NORMAL AND DISEASE STATES
    JOHN DEARBORN PHILLIPS; Fiscal Year: 2012
    ..We will test the hypothesis that suppression of hepcidin expression is responsible for the excess liver iron stores...
  55. Iron Excess and Risk of Infection in Liver Transplant Recipients
    Jennifer K Chow; Fiscal Year: 2013
    ..Iron is a universal nutrient for nearly all pathogens. The iron hormone, hepcidin, is thought to be the central regulator of human iron metabolism, and consequently, controls host serum iron ..
  56. Influence of Iron on Murine Malaria
    David Joseph Sullivan; Fiscal Year: 2012
    ..the influence of iron supplementation and timing of malaria infection in genotypic iron defective mice for hepcidin or also erythroid, not hepatic, iron uptake and 3) to correlate malaria outcomes with hematologic biomarkers like ..
  57. Curry L Koening; Fiscal Year: 2016
    ..Molecular evidence supports that an infectious organism causes GCA. We showed hepcidin, an iron-regulatory hormone, is expressed in the temporal artery wall of patients with GCA...
  58. Marc J Semigran; Fiscal Year: 2016
    ..utilization during low level exercise, and relate changes in hemoglobin, iron stores, the iron-regulatory protein hepcidin, and novel iron-dependent metabolomic profiles to changes in exercise capacity in order to identify patients most ..
  59. Towards Measures of Lupus Nephritis Activity &Damage for Children
    Hermine I Brunner; Fiscal Year: 2012
    ..associated lipocalin, transferrin, ceruloplasmin, al-acid glycoprotein, chemokine ligand 2, adiponectin, hepcidin, liver-type fatty acid binding protein, and lipocalin-like prostaglandin-D synthetase, can noninvasively and ..
  60. Nancy Berliner; Fiscal Year: 2015
    ..sub-sample of the VITAL cohort, we will investigate whether vitamin D and/or ?-3 FA influence erythropoiesis via hepcidin- and/or erythropoietin (EPO)-dependent pathways...
  61. Inflammation, Anemia and Respiratory Distress in Mothers and Infants with Malaria
    WHITNEY ELIZABETH HARRINGTON; Fiscal Year: 2011
    ..related to resistant parasites also affects risk of maternal anemia, specifically by increasing IL-6 and hepcidin levels...
  62. The role of hemojuvelin in the regulation of iron metabolism
    Tomas Ganz; Fiscal Year: 2007
    ..The peptide hormone hepcidin emerged as the principal regulator of systemic iron homeostasis...
  63. Michael L Merchant; Fiscal Year: 2015
    ..and protein fragments classify EPO response with more sensitivity and specificity than C-reactive protein and hepcidin. We hypothesize that specific serum proteins and peptides are candidate surrogate biomarkers for EPO ..
  64. MARK EDWARD WESTERMAN; Fiscal Year: 2014
    ..stratification, earlier therapeutic interventions, and drug development for AKI Recently, we have shown that hepcidin is a small peptide (2...
  65. Fluorescence-based screen to probe hepcidin-ferroportin interactions
    Marianne Wessling Resnick; Fiscal Year: 2006
    ..The most important recent discovery has been the role of the liver-derived peptide hepcidin. Hepcidin is produced under iron- loading and inflammatory conditions to suppress dietary iron absorption and ..