H3F3B

Summary

Gene Symbol: H3F3B
Description: H3 histone family member 3B
Alias: H3.3B, histone H3.3, H3 histone, family 3B (H3.3B)
Species: human

Top Publications

  1. pmc Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain
    Junji Otani
    Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto Daigaku Katsura, Nishikyo ku, Kyoto 615 8510, Japan
    EMBO Rep 10:1235-41. 2009
  2. pmc A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes
    Radhika A Varier
    Department of Physiological Chemistry and Netherlands Proteomics Center, University Medical Centre Utrecht, Utrecht, The Netherlands
    EMBO J 29:3967-78. 2010
  3. doi Discovery, identification and sequence analysis of RNAs selected for very short or long poly A tail in immature bovine oocytes
    Maella Gohin
    Centre de Recherche en Biologie de la Reproduction, Faculté des sciences de l agriculture et de l alimentation, Departement des Sciences Animales, 2440 Bl Hochelaga, Pavillon INAF, Universite Laval, Quebec, QC, Canada G1V 0A6
    Mol Hum Reprod 20:127-38. 2014
  4. pmc ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression
    Hong Wen
    1 Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA 2 Center for Cancer Epigenetics, Center for Genetics and Genomics, and Center for Stem Cell and Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA 3
    Nature 508:263-8. 2014
  5. pmc The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
    Robert Huether
    1 Department of Computational Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA 2
    Nat Commun 5:3630. 2014
  6. doi Giant cell tumor of bone: current treatment options
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, and the Masonic Cancer Center, Box 286, University Hospital, Minneapolis, MN, USA
    Curr Treat Options Oncol 15:507-18. 2014
  7. pmc Histone H3.3 regulates dynamic chromatin states during spermatogenesis
    Benjamin T K Yuen
    Department of Cell Biology and Human Anatomy, Shriners Hospital for Children Northern California, Sacramento, CA 95817, USA Genome Center, University of California Davis School of Medicine, Shriners Hospital for Children Northern California, Sacramento, CA 95817, USA Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, Sacramento, CA 95817, USA
    Development 141:3483-94. 2014
  8. doi Genetic Analysis of Diffuse High-Grade Astrocytomas in Infancy Defines a Novel Molecular Entity
    Gerrit H Gielen
    Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Brain Pathol 25:409-17. 2015
  9. doi The highly prevalent H3F3A mutation in giant cell tumours of bone is not shared by sporadic central giant cell lesion of the jaws
    Carolina Cavalieri Gomes
    Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol 118:583-5. 2014
  10. doi Diagnostic, prognostic and predictive relevance of molecular markers in gliomas
    Sebastian Brandner
    Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, UK
    Neuropathol Appl Neurobiol 41:694-720. 2015

Scientific Experts

  • Fausto J Rodriguez
  • D Capper
  • Sumihito Nobusawa
  • U Herrlinger
  • Alberto Broniscer
  • Keith M Skubitz
  • Kenneth Aldape
  • Kenichi Ishibashi
  • Yi Shing Lisa Cheng
  • Sriram Venneti
  • Akitake Mukasa
  • Helena Caren
  • Gerrit H Gielen
  • W Wick
  • Paul S Knoepfler
  • Lee H Wong
  • Ard M Nijhof
  • Wolfgang Mann
  • David T W Jones
  • Stefan M Pfister
  • Andrey Korshunov
  • Volker Hovestadt
  • Andreas von Deimling
  • Guido Reifenberger
  • Marcel Kool
  • Dominik Sturm
  • Nada Jabado
  • Adam M Fontebasso
  • Jeremy Schwartzentruber
  • Prerana Jha
  • Zhiguo Zhang
  • Jacek Majewski
  • Damien Faury
  • Xiao Yang Liu
  • Peter W Lewis
  • Kenta Masui
  • David E Reuss
  • Dong Fang
  • Pankaj Pathak
  • David Castel
  • Christina L Appin
  • Chris Jones
  • Christel Herold-Mende
  • Andreas Unterberg
  • Robert Huether
  • Benedikt Wiestler
  • Jinghui Zhang
  • Kui Ming Chan
  • Gang Wu
  • Sebastian Bender
  • Olaf Witt
  • Jörg Felsberg
  • V Peter Collins
  • Till Milde
  • Marc Zapatka
  • Hendrik Witt
  • Marina Ryzhova
  • Martin Ebinger
  • Peter Lichter
  • Christoph Plass
  • Steffen Albrecht
  • C David Allis
  • Marc Zanello
  • Pascale Varlet
  • Jens Schittenhelm
  • M Fernanda Amary
  • Sebastian Brandner
  • Ashish Suri
  • Alan Mackay
  • Jacques Grill
  • Stephanie Puget
  • Vaishali Suri
  • Chitra Sarkar
  • Haiyun Gan
  • Michael Platten
  • Michael Weller
  • Kelly M Bush
  • Charles G Mullighan
  • Richard J Gilbertson
  • Elaine R Mardis
  • Suzanne J Baker
  • Li Ding
  • Matthew Parker
  • David W Ellison
  • Richard K Wilson
  • James R Downing
  • Jared Becksfort
  • Laszlo Bognar
  • Miklos Garami
  • Pawel P Liberski

Detail Information

Publications115 found, 100 shown here

  1. pmc Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain
    Junji Otani
    Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto Daigaku Katsura, Nishikyo ku, Kyoto 615 8510, Japan
    EMBO Rep 10:1235-41. 2009
    ..These results indicate that de novo DNA methylation by DNMT3A requires the alteration of chromatin structure...
  2. pmc A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes
    Radhika A Varier
    Department of Physiological Chemistry and Netherlands Proteomics Center, University Medical Centre Utrecht, Utrecht, The Netherlands
    EMBO J 29:3967-78. 2010
    ..Based on our observations, we propose that a histone H3 phospho-methyl switch regulates TFIID-mediated transcription during mitotic progression of the cell cycle...
  3. doi Discovery, identification and sequence analysis of RNAs selected for very short or long poly A tail in immature bovine oocytes
    Maella Gohin
    Centre de Recherche en Biologie de la Reproduction, Faculté des sciences de l agriculture et de l alimentation, Departement des Sciences Animales, 2440 Bl Hochelaga, Pavillon INAF, Universite Laval, Quebec, QC, Canada G1V 0A6
    Mol Hum Reprod 20:127-38. 2014
    ..Moreover, we identified deadenylated RNAs in bovine oocytes that may be stored for the long-term process of early embryo development and described a conserved motif enriched in the 3'UTR of deadenylated RNAs...
  4. pmc ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression
    Hong Wen
    1 Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA 2 Center for Cancer Epigenetics, Center for Genetics and Genomics, and Center for Stem Cell and Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA 3
    Nature 508:263-8. 2014
    ..Together, this study identifies ZMYND11 as an H3.3-specific reader of H3K36me3 that links the histone-variant-mediated transcription elongation control to tumour suppression. ..
  5. pmc The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
    Robert Huether
    1 Department of Computational Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA 2
    Nat Commun 5:3630. 2014
    ..Collectively, our results help to define the landscape of mutations in epigenetic regulatory genes in paediatric cancer and yield a valuable new database for investigating the role of epigenetic dysregulations in cancer. ..
  6. doi Giant cell tumor of bone: current treatment options
    Keith M Skubitz
    Department of Medicine, University of Minnesota Medical School, and the Masonic Cancer Center, Box 286, University Hospital, Minneapolis, MN, USA
    Curr Treat Options Oncol 15:507-18. 2014
    ..The role of denosumab in the preoperative or adjuvant setting will require clinical trials. In some cases local radiation therapy may be useful, although long term effects should be considered...
  7. pmc Histone H3.3 regulates dynamic chromatin states during spermatogenesis
    Benjamin T K Yuen
    Department of Cell Biology and Human Anatomy, Shriners Hospital for Children Northern California, Sacramento, CA 95817, USA Genome Center, University of California Davis School of Medicine, Shriners Hospital for Children Northern California, Sacramento, CA 95817, USA Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, Sacramento, CA 95817, USA
    Development 141:3483-94. 2014
    ..Recently, we developed a knockout mouse model for the H3f3b gene, one of two genes encoding H3.3...
  8. doi Genetic Analysis of Diffuse High-Grade Astrocytomas in Infancy Defines a Novel Molecular Entity
    Gerrit H Gielen
    Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Brain Pathol 25:409-17. 2015
    ..Our findings indicate that infant high-grade gliomas appear to represent a distinct genetic entity suggesting a different pathogenesis and biological behavior. ..
  9. doi The highly prevalent H3F3A mutation in giant cell tumours of bone is not shared by sporadic central giant cell lesion of the jaws
    Carolina Cavalieri Gomes
    Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol 118:583-5. 2014
    ..Gly34 Trp or p.Gly34 Leu in H3F3A, one of two genes for histone H3.3 located on chromosome 1. We aimed to test whether sporadic CGCL of the jaws share the H3F3A mutations reported in GCT of other bones...
  10. doi Diagnostic, prognostic and predictive relevance of molecular markers in gliomas
    Sebastian Brandner
    Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, UK
    Neuropathol Appl Neurobiol 41:694-720. 2015
    ..In a tumour-specific topic, the role of mitogen-activated protein kinase pathway mutations in the pathogenesis of pilocytic astrocytomas will be covered. ..
  11. doi Biomarker-driven diagnosis of diffuse gliomas
    Christina L Appin
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Mol Aspects Med 45:87-96. 2015
    ..These gliomas often harbor mutations or activating gene rearrangements in BRAF. ..
  12. doi Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities
    David E Reuss
    Department of Neuropathology, Institute of Pathology, University of Heidelberg, INF 224, 69120, Heidelberg, Germany
    Acta Neuropathol 130:407-17. 2015
    ..The diagnosis of IDHwt diffuse astrocytoma or anaplastic astrocytoma should be used with caution. ..
  13. pmc Detecting the H3F3A mutant allele found in high-grade pediatric glioma by real-time PCR
    Ray Zhang
    Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 1st SW, Rochester, MN, 55905, USA
    J Neurooncol 126:27-36. 2016
    ..These results demonstrate that we have developed a new reliable procedure for detecting the H3F3A K27M mutation in pediatric glioblastoma patient samples...
  14. pmc Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes
    David Castel
    UMR8203 Vectorologie et Thérapeutiques Anticancéreuses, CNRS, Gustave Roussy, Univ Paris Sud, Université Paris Saclay, 94805, Villejuif, France
    Acta Neuropathol 130:815-27. 2015
    ..H3K27 alterations appear as the founding event in DIPG and the mutations in the two main histone H3 variants drive two distinct oncogenic programmes with potential specific therapeutic targets. ..
  15. doi Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma
    Arjen H G Cleven
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Surg Pathol 39:1576-83. 2015
    Specific H3F3A driver mutations and IDH2 mutations were recently described in giant cell tumor of bone (GCTB) and H3F3B driver mutations in chondroblastoma; these may be helpful as a diagnostic tool for giant cell-containing tumors of ..
  16. doi Molecular classification of gliomas
    Kenta Masui
    Department of Pathology, Tokyo Women s Medical University, Shinjku ku, Tokyo, Japan Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, USA
    Handb Clin Neurol 134:97-120. 2016
    ..Finally, we illustrate how advances in molecular diagnostics affect novel strategies of targeted therapy, thereby raising new challenges and identifying new leads for personalized treatment of glioma patients. ..
  17. doi [Molecular Genetics as Best Evidence in Glioma Diagnostics]
    Kenta Masui
    Department of Pathology, Tokyo Women s Medical University
    Brain Nerve 68:253-61. 2016
    ....
  18. ncbi Clinical, Imaging, Histopathological and Molecular Characterization of Anaplastic Ganglioglioma
    Marc Zanello
    From the Department of Neurosurgery MZ, ED, Bd, JP, Department of Neuropathology, Sainte Anne Hospital, Paris, France MP, AT E, FC, FA, PV, Department of Biochemistry, Paul Brousse Hospital, Paris, France RS Department of Pediatric Neurosurgery, Necker Enfants Malades Hospital, Paris, France SP, CS R, MZ, Paris Descartes University, Paris, France MZ, MP, AT E, SP, ED, Bd, FC, FA, CS R, MZ, J FM, JP, PV, Department of Medical Biology and Pathology LL, Department of Neurooncology, UK
    J Neuropathol Exp Neurol 75:971-980. 2016
    ..K27M H3F3A mutation (17%). AGGs are malignant neoplasms requiring aggressive oncological treatment. In the perspective of targeted therapies, AGGs should be screened for BRAF V600E, hTERT, ATRX, and mutations of histone genes...
  19. pmc Chronic periodontitis can affect the levels of potential oral cancer salivary mRNA biomarkers
    Y S L Cheng
    Department of Diagnostic Sciences, Texas A and M University College of Dentistry, Dallas, TX, USA
    J Periodontal Res . 2016
    ..The seven salivary mRNAs were interleukin (IL)-8, IL-1β, dual specificity phosphatase 1, H3 histone family 3A, ornithine decarboxylase antizyme 1, S100 calcium-binding protein P (S100P) and spermidine/spermine N1-acetyltransferase 1...
  20. doi Histone variant H3F3A promotes lung cancer cell migration through intronic regulation
    Seong Min Park
    Specific Organs Cancer Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi 10408, Republic of Korea
    Nat Commun 7:12914. 2016
    ..In summary, our results demonstrate that intronic regulation by H3F3A may be a target for the development of novel therapeutic strategies...
  21. pmc H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions
    Chunyuan Jin
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 41:941-5. 2009
    ..Other combinations of variants have different distributions, consistent with distinct roles for histone variants in the modulation of gene expression...
  22. pmc Distinct factors control histone variant H3.3 localization at specific genomic regions
    Aaron D Goldberg
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cell 140:678-91. 2010
    ..3 at telomeres and for the repression of telomeric RNA. Our data demonstrate that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells...
  23. pmc PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity
    Sujit S Nair
    Department of Obstetrics and Gynecology, University of Texas Health Science Center in San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    EMBO Rep 11:438-44. 2010
    ..These results suggest that PELP1 is a reader of H3 methylation marks and has a crucial role in modulating the histone code at the ERalpha target genes...
  24. pmc Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
    Peter W Lewis
    Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:14075-80. 2010
    ..These data demonstrate that Daxx functions as an H3.3-specific chaperone and facilitates the deposition of H3.3 at heterochromatin loci in the context of the ATRX-Daxx complex...
  25. doi Structures of human nucleosomes containing major histone H3 variants
    Hiroaki Tachiwana
    Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo 162 8480, Japan
    Acta Crystallogr D Biol Crystallogr 67:578-83. 2011
    ..1 nucleosome. Since the amino-acid residues specific for H3.2 and H3.3 are located on the accessible surface of the H3/H4 tetramer, they may be potential interaction sites for H3.2- and H3.3-specific chaperones...
  26. pmc Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN
    Lynn Bjerke
    Divisions of Molecular Pathology and Cancer Therapeutics The Institute of Cancer Research, Suttonn, Surrey, United Kingdom
    Cancer Discov 3:512-9. 2013
    ..This driving aberration is selectively targetable in this patient population through inhibiting kinases responsible for stabilization of the protein...
  27. doi Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
    Sebastian Bender
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany
    Cancer Cell 24:660-72. 2013
    ....
  28. pmc A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly
    Junhong Han
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Cell 155:817-29. 2013
    ....
  29. doi Molecular analysis of diffuse intrinsic brainstem gliomas in adults
    Germán Reyes-Botero
    Service de neurologie 2, AP HP, Groupe Hospitalier Pitie Salpetriere, Paris, France
    J Neurooncol 116:405-11. 2014
    ..These data suggest that adult DIBG differ from adult supratentorial gliomas. In particular, histone genes (H3F3A (K27M) , HIST1H3B (K27M) ) mutations are frequent in adult DIBG whereas IDH1 (R132H) mutations are rare...
  30. doi Molecular genetics of gliomas
    Christina L Appin
    From the Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA
    Cancer J 20:66-72. 2014
    ..Other lower-grade gliomas of childhood, such as pilocytic astrocytoma and pleomorphic xanthoastrocytoma, are characterized by BRAF mutations or activating gene rearrangements involving BRAF. ..
  31. pmc Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas
    Liwei Zhang
    1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China 2
    Nat Genet 46:726-30. 2014
    ..These results define PPM1D as a frequent target of somatic mutation and as a potential therapeutic target in brainstem gliomas. ..
  32. pmc Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma
    Sama Ahsan
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 1800 Orleans St, 21287 Baltimore, MD, USA
    Acta Neuropathol Commun 2:59. 2014
    ..An H-score was derived by multiplying intensity (0-2) by percentage of positive tumor nuclei (0-100%)...
  33. pmc Genome-wide methylation profiling identifies an essential role of reactive oxygen species in pediatric glioblastoma multiforme and validates a methylome specific for H3 histone family 3A with absence of G-CIMP/isocitrate dehydrogenase 1 mutation
    Prerana Jha
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India P J, P P, VI S, VA S, M C S, C S Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India I R P P, S S, J P, S T, K S Department of Neuropathology, National Institute of Mental Health and Neuro Sciences, Bangalore, India VAI S Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India A A Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India A S, D G
    Neuro Oncol 16:1607-17. 2014
    ..The present study aims to validate these findings in an independent cohort of pediatric GBM, compare it with adult GBM, and evaluate the involvement of important functionally altered pathways...
  34. doi Identification of stably expressed reference genes for RT-qPCR data normalization in defined localizations of cyclic bovine ovaries
    K Schoen
    Department of Veterinary Medicine, Institute of Veterinary Anatomy, Freie Universitat Berlin, Koserstraße 20, 14195, Berlin, Germany
    Anat Histol Embryol 44:200-11. 2015
    ..profiles of twelve potential reference genes (GAPDH, ACTB, YWHAZ, HPRT1, SDHA, UBA52, POLR2C, RPS9, ACTG2, H3F3B, RPS18 and RPL19) were analysed...
  35. doi Molecular genetics of ependymomas and pediatric diffuse gliomas: a short review
    Sumihito Nobusawa
    Department of Human Pathology, Gunma University Graduate School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma, 371 8511, Japan
    Brain Tumor Pathol 31:229-33. 2014
    ..Moreover, in diffuse intrinsic pontine gliomas (DIPG), recurrent somatic mutations of ACVR1 were found in association with HIST1H3B mutations. ..
  36. doi ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma
    David E Reuss
    German Cancer Consortium DKTK, CCU Neuropathology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Acta Neuropathol 129:133-46. 2015
    ....
  37. doi Altered global histone-trimethylation code and H3F3A-ATRX mutation in pediatric GBM
    Pankaj Pathak
    Department of Pathology, All India Institute of Medical Sciences AIIMS, New Delhi, India
    J Neurooncol 121:489-97. 2015
    ..Hence therapies for patients with particular combinations of histone modifications present opportunity to design innovative patient-tailored treatment protocols...
  38. doi Evaluation of housekeeping genes for normalizing real-time quantitative PCR assays in pig skeletal muscle at multiple developmental stages
    Yueying Wang
    Key Lab of Swine Genetics and Breeding of Ministry of Agriculture, Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Central China Agricultural University, Wuhan, Hubei, PR China
    Gene 565:235-41. 2015
    ..This result provides a strong basis for similar studies in pigs that explore the molecular mechanisms underlying skeletal muscle development...
  39. doi Glioblastoma: pathology, molecular mechanisms and markers
    Kenneth Aldape
    Princess Margaret Cancer Centre and MacFeeters Hamilton Centre for Neuro Oncology Research, 101 College St, Toronto, ON, M5G 1L7, Canada
    Acta Neuropathol 129:829-48. 2015
    ....
  40. doi Genome-wide small noncoding RNA profiling of pediatric high-grade gliomas reveals deregulation of several miRNAs, identifies downregulation of snoRNA cluster HBII-52 and delineates H3F3A and TP53 mutant-specific miRNAs and snoRNAs
    Prerana Jha
    Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology, New Delhi, India
    Int J Cancer 137:2343-53. 2015
    ..The comparison of miRNA profiles of pediatric HGGs and adult GBM reiterates the overlaps and differences as also seen with their gene expression and methylation signatures...
  41. pmc Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres
    Maheshi Udugama
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Nucleic Acids Res 43:10227-37. 2015
    ..3K9 at telomeres. In H3f3a(-/-) and H3f3b(-/-) mouse embryonic stem cells (ESCs), H3...
  42. pmc Biomarker-based prognostic stratification of young adult glioblastoma
    Rui qi Zhang
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China
    Oncotarget 7:5030-41. 2016
    ..In summary, our study demonstrates the clinical values of stratifying young adult glioblastomas with BRAF, H3F3A and IDH1 mutations, which has important implications in refining prognostic classification of glioblastomas...
  43. pmc Gliomatosis cerebri in children shares molecular characteristics with other pediatric gliomas
    Alberto Broniscer
    Department of Oncology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA
    Acta Neuropathol 131:299-307. 2016
    ..Like in adults, the similarity of genetic and epigenetic characteristics with other infiltrative high-grade gliomas suggests that pediatric GC does not represent a distinct molecular entity. ..
  44. doi The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma
    M Fernanda Amary
    Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, UK
    Histopathology 69:121-7. 2016
    We recently reported that 95% of chondroblastomas harbour a p.K36M mutation in either H3F3A (chromosome 1) or H3F3B (chromosome 17), with the majority involving H3F3B...
  45. pmc Symplastic/pseudoanaplastic giant cell tumor of the bone
    Judy Sarungbam
    Department of Pathology, Memorial Sloan Kettering Cancer Center MSKCC, 1275 York Avenue, New York, NY, 10065, USA
    Skeletal Radiol 45:929-35. 2016
    ..Recently, somatic driver mutations of histone H3.3 exclusively in H3F3A have been described in GCTB. We report a series of 9 cases of GCTB with symplastic/pseudoanaplastic change, along with analysis of H3F3A variants...
  46. doi Pseudoprogression in children, adolescents and young adults with non-brainstem high grade glioma and diffuse intrinsic pontine glioma
    Fernando Carceller
    Children and Young People s Unit, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK
    J Neurooncol 129:109-21. 2016
    ..107-0.882; p = 0.028) in DIPG. PsP occurred in both pediatric HGG and DIPG patients at a comparable rate to adult HGG. PsP was associated with improved 1-yr PFS in HGG patients. PsP had a protective effect upon OS in DIPG patients. ..
  47. doi K27M mutation in H3F3A in ganglioglioma grade I with spontaneous malignant transformation extends the histopathological spectrum of the histone H3 oncogenic pathway
    Natacha Joyon
    Neuropathologie, Laboratoire Escourolle, Hôpitaux Universitaires Pitié Salpêtrière Charles Foix, AP HP, Paris, France
    Neuropathol Appl Neurobiol . 2016
    ..The most frequent genetic alterations in ganglioglioma are BRAF p.V600E mutation (40-60%), gain of chromosomes 7 (23%) and 5 (18%) (1-4). This article is protected by copyright. All rights reserved...
  48. doi In silico analysis of histone H3 gene expression during human brain development
    Megan Ren
    Program in Cell and Molecular Biology, Michigan State University, MI, USA
    Int J Dev Biol 60:167-73. 2016
    ..3s for the K27-AAG codon and the functional relationship between H3.3 and PRC2, whereas overrepresentation of K27M mutations in HIST1H3B may be a product of strong relative expression of this gene in the early developing brain. ..
  49. pmc ATRX immunostaining predicts IDH and H3F3A status in gliomas
    Azadeh Ebrahimi
    Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, Calwerstr 3, D 72076, Tuebingen, Germany
    Acta Neuropathol Commun 4:60. 2016
    ..Such classification is of great importance for further clinical decision making especially concerning the therapeutic options available for diffuse gliomas. ..
  50. ncbi Pediatric thalamic glioma with H3F3A K27M mutation, which was detected before and after malignant transformation: a case report
    Kenichi Ishibashi
    Department of Neurosurgery, Osaka City General Hospital, 2 13 22 Miyakojima Hondori, Miyakojima ku, Osaka, 534 0021, Japan
    Childs Nerv Syst 32:2433-2438. 2016
    ....
  51. ncbi Histologic Spectrum of Giant Cell Tumor (GCT) of Bone in Patients 18 Years of Age and Below: A Study of 63 Patients
    Alyaa Al-Ibraheemi
    Departments of Laboratory Medicine and Pathology Radiology Biomedical Statistics and Informatics Orthopedic Surgery, Mayo Clinic, Rochester, MN
    Am J Surg Pathol 40:1702-1712. 2016
    ..Clinical/radiologic records were reviewed when available. Analysis for H3F3A/H3F3B mutations was performed in a subset of cases...
  52. pmc Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma
    Scott Ryall
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol Commun 4:93. 2016
    ..Our data strongly supports the inclusion of targeted genetic testing in childhood thalamic tumours to most accurately stratify patients into appropriate risk groups. ..
  53. ncbi Study of hTERT and Histone 3 Mutations in Medulloblastoma
    Marta Viana-Pereira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Pathobiology . 2016
    ..On the other hand, histone 3 mutations do not seem to be present in medulloblastoma...
  54. doi H3F3 mutation status of giant cell tumors of the bone, chondroblastomas and their mimics: a combined high resolution melting and pyrosequencing approach
    Thibault Kervarrec
    Department of Pathology, University Hospital of Tours, avenue de la Republique, Chambray les Tours, France
    Mod Pathol . 2017
    ..H3F3A and H3F3B were found in 85% of giant cell tumors of the bone and 88% of chondroblastomas...
  55. pmc The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children
    Julieann Lee
    Division of Neuropathology, Department of Pathology, University of California, San Francisco, 505 Parnassus Ave, Room M 551, Box 0102, San Francisco, CA, 94143, USA
    J Neurooncol . 2017
    ..We present a review of these mutations affecting the histone code and telomere length, highlighting their importance in prognosis and as targets for novel therapeutics in the treatment of diffuse gliomas...
  56. doi Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells
    Dong Fang
    a Department of Pediatrics and Department of Genetics and Development, Institute for Cancer Genetics, Irving Cancer Research Center, Columbia University, 1130 St Nicholas Avenue, New York, NY, 10032, USA
    Cell Cycle . 2017
    ..Recent studies have identified a somatic and heterozygous mutation at the H3F3B gene in over 90% chondroblastoma cases, leading to a lysine 36 to methionine replacement (H3.3K36M)...
  57. ncbi Sexually dimorphic gene expression in the hypothalamus, pituitary gland, and cortex
    Yuichiro Nishida
    Functional Genomics Laboratory, Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, Department of Anatomy and Physiology, Laval University, 2705 Boulevard Laurier, Quebec, Quebec, Canada G1V 4G2
    Genomics 85:679-87. 2005
    ..Thus, the current study has characterized key sexual dimorphisms in the transcriptomes of the hypothalamus, pituitary, and cortex...
  58. ncbi [The structure of a conserved region of porcine genome, represented in human genome by chromosome 17]
    D M Larkin
    Genetika 40:961-7. 2004
    Radiation mapping of nine genes (H3F3B, HLR1, MYL4, STAT5B, THRA1, TOP2A, MCP1, NF1, and MPO) to porcine chromosome 12 was carried out...
  59. ncbi Localization of the human H3F3A histone gene to 1q41, outside of the normal histone gene clusters
    X Lin
    Department of Biology, University of Houston, Texas 77204, USA
    Genomics 46:526-8. 1997
  60. pmc Dietary zinc modulates gene expression in murine thymus: results from a comprehensive differential display screening
    J Bernadette Moore
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department and Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    Proc Natl Acad Sci U S A 100:3883-8. 2003
    ..Several genes involved in T cell development were identified as regulated by zinc and will be targets to evaluate the effects of zinc on immune function...
  61. doi HIV-1 Tat protein induces IL-10 production in monocytes by classical and alternative NF-kappaB pathways
    Kaoutar Leghmari
    Laboratoire d Immuno Virologie, EA 3038, Universite Paul Sabatier, 118, route de Narbonne, Bâtiment 4R3, F 31062 Toulouse Cedex, France
    Eur J Cell Biol 87:947-62. 2008
    ..As a whole, the study demonstrates that Tat activates at least three signaling pathways concurrently, including the classical, alternative and IKKalpha pathways, to promote production of IL-10...
  62. pmc Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt
    Clemens Grimm
    European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France
    EMBO J 28:1965-77. 2009
    ....
  63. pmc Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas
    Sriram Venneti
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Brain Pathol 23:558-64. 2013
    ..Our results indicate that H3F3A K27M mutant GBMs show decreased H3K27me3 that may be of both diagnostic and biological relevance. ..
  64. doi BRCA1 and p53 regulate critical prostate cancer pathways
    P De Luca
    Department of Biological Chemistry, School of Sciences FCEN, University of Buenos Aires UBA, IQUIBICEN CONICET, Buenos Aires, Argentina
    Prostate Cancer Prostatic Dis 16:233-8. 2013
    ..Considering that p53 is a crucial target in cancer therapy, in this work we investigated p53 role in the regulation of transcription of GADD153...
  65. pmc Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
    David T W Jones
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Nat Genet 45:927-32. 2013
    ..Our findings thus identify new potential therapeutic targets in distinct subsets of pilocytic astrocytoma and childhood glioblastoma. ..
  66. pmc A lesson learned from the H3.3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo?
    Kui Ming Chan
    Department of Biochemistry and Molecular Biology, Epigenomic Developmental Program, Center of Individualized Medicine, Mayo Clinic, Rochester, MN, USA
    Cell Cycle 12:2546-52. 2013
    ....
  67. pmc Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
    Sam Behjati
    1 Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK 2 Department of Paediatrics, University of Cambridge, Cambridge, UK 3
    Nat Genet 45:1479-82. 2013
    ..In 73 of 77 cases of chondroblastoma (95%), we found p.Lys36Met alterations predominantly encoded in H3F3B, which is one of two genes for histone H3.3...
  68. pmc Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas
    Christine G Joseph
    Ludwig Center, the Howard Hughes Medical Institutions, and the Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287
    Genes Chromosomes Cancer 53:15-24. 2014
    ..These results provide intriguing nucleotide-level information on these relatively uncommon neoplasms and highlight pathways that help explain their pathogenesis...
  69. pmc H3F3A K27M mutations in thalamic gliomas from young adult patients
    Koki Aihara
    Corresponding authors Akitake Mukasa, MD, PhD, Department of Neurosurgery, The University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan Hiroyuki Aburatani, MD, PhD, Genome Science Division, Research Center for Advanced Science and Technology RCAST, The University of Tokyo, 4 6 1 Komaba, Meguro ku, Tokyo 153 8904, Japan
    Neuro Oncol 16:140-6. 2014
    ..Here, we sought to determine the association between H3F3A mutations and adult thalamic glioma...
  70. pmc Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia
    Zeynep Kalender Atak
    Laboratory of Computational Biology, Center for Human Genetics, KU Leuven, Leuven, Belgium
    PLoS Genet 9:e1003997. 2013
    ....
  71. ncbi Identification of novel variant, 1484delG in the 3'UTR of H3F3B, a member of the histone 3B replacement family, in ovarian tumors
    Nadege Presneau
    Department of Human Genetics, McGill University, Montreal, H3A 1B1, Canada
    Int J Oncol 26:1621-7. 2005
    ..RT-PCR validation of Affymetrix GeneChip expression of H3F3B, a member of the 3B histone family that maps to 17q25...
  72. doi Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    Jeremy Schwartzentruber
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec H3A 1A4, Canada
    Nature 482:226-31. 2012
    ..This is, to our knowledge, the first report to highlight recurrent mutations in a regulatory histone in humans, and our data suggest that defects of the chromatin architecture underlie paediatric and young adult GBM pathogenesis...
  73. pmc Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
    Gang Wu
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 44:251-3. 2012
    ..3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration...
  74. pmc U7 small nuclear ribonucleoprotein represses histone gene transcription in cell cycle-arrested cells
    Takashi Ideue
    Functional RNomics Team, Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology AIST, Koutou, Tokyo 135 0064, Japan
    Proc Natl Acad Sci U S A 109:5693-8. 2012
    ..elevated levels of replication-dependent H1, H2A, H2B, H3, and H4 histone mRNAs but not of replication-independent H3F3B histone mRNA...
  75. pmc The good, the bad and the ugly: epigenetic mechanisms in glioblastoma
    Helena Caren
    UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, United Kingdom
    Mol Aspects Med 34:849-62. 2013
    ..3/H3F3A. These constitute the 'good, the bad and the ugly' of epigenetic mechanisms in cancer...
  76. doi Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
    Xiao Yang Liu
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Acta Neuropathol 124:615-25. 2012
    ..Combined alteration of these genes may contribute to drive the neoplastic growth in a major subset of diffuse astrocytomas in adults...
  77. pmc An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest
    Samuel G Cox
    Department of Cell and Neurobiology, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS Genet 8:e1002938. 2012
    ..3 in the broad potential of the ectoderm-derived CNC, including the ability to make the mesoderm-like ectomesenchymal precursors of the head skeleton...
  78. doi Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
    Dominik Sturm
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ Heidelberg, 69120 Heidelberg, Germany
    Cancer Cell 22:425-37. 2012
    ..We also demonstrate that the two H3F3A mutations give rise to GBMs in separate anatomic compartments, with differential regulation of transcription factors OLIG1, OLIG2, and FOXG1, possibly reflecting different cellular origins...
  79. doi CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches
    Saria El Haddad
    Department of Pediatric, American University of Beirut, Beirut, Lebanon
    Electrophoresis 33:3798-809. 2012
    ..We explore the role of the CLN5/CLN8 proteins in ceramide species specific sphingolipid de novo synthesis, and suggest that CLN5/CLN8 proteins are more closely related than previously believed...
  80. pmc Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
    Adam M Fontebasso
    Division of Experimental Medicine, McGill University and McGill University Health Centre, Montreal, QC, Canada
    Acta Neuropathol 125:659-69. 2013
    ..Taken together, our results suggest that mutations disrupting the histone code at H3K36, including H3.3 G34R/V, IDH1 and/or SETD2 mutations, are central to the genesis of hemispheric HGGs in older children and young adults...
  81. doi H3F3A K27M mutation in pediatric CNS tumors: a marker for diffuse high-grade astrocytomas
    Gerrit H Gielen
    Institute of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Am J Clin Pathol 139:345-9. 2013
    ..Because H3F3A K27M mutations occur exclusively in pediatric diffuse high-grade astrocytomas, analysis of codon 27 mutational status could be useful in the differential diagnosis of these neoplasms...
  82. pmc Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
    Peter W Lewis
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Science 340:857-61. 2013
    ..We propose that K-to-M substitutions may represent a mechanism to alter epigenetic states in a variety of pathologies...
  83. pmc Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development
    Kelly M Bush
    Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, 4303 Tupper Hall, Davis, CA, 95616, USA
    Epigenetics Chromatin 6:7. 2013
    ..3 in mammalian cells and during development has been less thoroughly investigated. To address this gap, we report the production and phenotypic analysis of mice and cells with targeted disruption of the H3.3-encoding gene, H3f3b.
  84. pmc Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
    Jinghui Zhang
    Department of Computational Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 45:602-12. 2013
    ..Focusing on the therapeutically challenging diffuse LGGs, our study of 151 tumors has discovered genetic alterations and potential therapeutic targets across the entire range of pediatric LGGs and LGGNTs...
  85. pmc Malignant astrocytomas of elderly patients lack favorable molecular markers: an analysis of the NOA-08 study collective
    Benedikt Wiestler
    German Cancer Consortium, Heidelberg, Germany
    Neuro Oncol 15:1017-26. 2013
    ....
  86. pmc The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
    Kui Ming Chan
    Department of Biochemistry and Molecular Biology, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 27:985-90. 2013
    ..These results indicate that H3.3K27M mutation reprograms epigenetic landscape and gene expression, which may drive tumorigenesis...
  87. pmc G34, another connection between MYCN and a pediatric tumor
    Miller Huang
    University of California San Francisco, San Francisco, CA, USA
    Cancer Discov 3:484-6. 2013
    ..In this issue of Cancer Discovery, Bjerke and colleagues identify mutations at G34 in H3F3A that result in elevated expression of MYCN as a potential mechanism in gliomagenesis...
  88. ncbi A Drosophila melanogaster H3.3 cDNA encodes a histone variant identical with the vertebrate H3.3
    S Fretzin
    Department of Biology, Washington University, St Louis, MO 63130
    Gene 107:341-2. 1991
    ..3 histone variant itself is an important structural component of chromatin, apart from the value of its replication-independent expression pattern...
  89. ncbi Structure and expression of histone H3.3 genes in Drosophila melanogaster and Drosophila hydei
    A S Akhmanova
    Department of Molecular and Developmental Genetics, Faculty of Sciences, Catholic University of Nijmegen, The Netherlands
    Genome 38:586-600. 1995
    ..However, in contrast to their vertebrate counterparts, which are highly conserved in their noncoding regions, the Drosophila genes display only limited sequence similarity in these regions...
  90. ncbi The human replacement histone H3.3B gene (H3F3B)
    W Albig
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat Gottingen, Germany
    Genomics 30:264-72. 1995
    ..The newly discovered human H3.3B gene (HGMW-approved symbol H3F3B) was mapped by fluorescence in situ hybridization to the telomeric region of chromosome 17 (17q25)...
  91. ncbi Transcriptional regulation of the human replacement histone gene H3.3B
    O Witt
    Institut fur Biochemie und Molekulare Zellbiologie, Universitat Gottingen, Germany
    FEBS Lett 408:255-60. 1997
    ..Band shift experiments identified binding proteins as Oct-1 and factors of the CREB/ATF and AP-1 family, respectively. The unexpected transcriptional regulation of this replacement histone gene is discussed...
  92. ncbi The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3
    A Palaparti
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 272:26604-10. 1997
    ....
  93. ncbi HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3
    P Magnaghi
    Molecular Medicine Unit, Institute of Child Health, London, UK
    Nat Genet 20:74-7. 1998
    ..HIRA was also found to interact with core histones. Thus, altered stoichiometry of complexes containing HIRA may be important for the development of structures affected in WS and DGS...
  94. ncbi Tip60 acetylates six lysines of a specific class in core histones in vitro
    A Kimura
    Department of Cellular Biology, University of Tokyo, Japan
    Genes Cells 3:789-800. 1998
    ....
  95. ncbi MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28
    S Zhong
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    J Biol Chem 276:12932-7. 2001
    ..These results suggest that UVB-induced H3 phosphorylation at serine 28 may be mediated by mitogen-activated protein kinases...
  96. ncbi [Use of PCR markers for mapping swine chromosome 12]
    D M Larkin
    Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia
    Genetika 37:358-64. 2001
    ..subchromosomal mapping of genes TOP2A, THRA, BRCA1, GAS, HLR1, MYL4, LIS1, MCP1, ENO3, CRYB1, P4HB, STAT5B, and H3F3B to pig chromosome 12 was carried out...
  97. pmc Methylation at arginine 17 of histone H3 is linked to gene activation
    Uta Maria Bauer
    Wellcome CRC Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    EMBO Rep 3:39-44. 2002
    ..Together these results demonstrate that CARM1 is recruited to an active promoter and that CARM1-mediated R17 methylation on histone H3 takes place in vivo during this active state...
  98. ncbi Differential expression of human replacement and cell cycle dependent H3 histone genes
    Derk Frank
    Institut fur Biochemie und Molekulare Zellbiologie, Abteilung Molekularbiologie, Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Gene 312:135-43. 2003
    ..3A gene expression. The possible functional relevance of the differences between the two H3.3 genes in structure and expression is discussed...
  99. pmc Histone modifications defining active genes persist after transcriptional and mitotic inactivation
    Antigone Kouskouti
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Herakleion, Crete, Greece
    EMBO J 24:347-57. 2005
    ..The findings suggest that histone modifications may function as molecular memory bookmarks for previously active locations of the genome, thus contributing to the maintenance of active chromatin states through cell division...
  100. ncbi Human Asf1 regulates the flow of S phase histones during replicational stress
    Anja Groth
    Institute of Cancer Biology, The Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Mol Cell 17:301-11. 2005
    ....
  101. ncbi PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation
    Mei Yu
    Abteilung Biochemie und Molekularbiologie, Institut fur Biochemie, Klinikum der RWTH, Pauwelsstrasse 30, 52057 Aachen, Germany
    Oncogene 24:1982-93. 2005
    ..Together, our findings define a novel PARP enzyme involved in the control of cell proliferation...