GSTP1

Summary

Gene Symbol: GSTP1
Description: glutathione S-transferase pi 1
Alias: DFN7, FAEES3, GST3, GSTP, HEL-S-22, glutathione S-transferase P, GST class-pi, GSTP1-1, deafness, X-linked 7, epididymis secretory protein Li 22, fatty acid ethyl ester synthase III
Species: human

Top Publications

  1. ncbi GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking
    Joachim Schneider
    Priv Doz Dr med Joachim Schneider, Institut und Poliklinik für Arbeits und Sozialmedizin, der Justus Liebig Universität, Aulweg 129 III, D 35385 Giessen, Germany
    Cancer Lett 208:65-74. 2004
  2. ncbi Polymorphisms of GSTT1 and related genes in head and neck cancer risk
    Adam J Evans
    Division of Hematology and Medical Oncology, Oregon Health and Science University, Mail Code L586, Portland, Oregon 97201, USA
    Head Neck 26:63-70. 2004
  3. ncbi Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway
    Halla Skuladottir
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Lung Cancer 48:187-99. 2005
  4. doi Glutathione S-transferase M1, T1, and P1 polymorphisms and ovarian cancer risk: a meta-analysis
    Konstantinos P Economopoulos
    School of Medicine, National University of Athens, Athens, Greece
    Int J Gynecol Cancer 20:732-7. 2010
  5. doi Potential risk modifications of GSTT1, GSTM1 and GSTP1 (glutathione-S-transferases) variants and their association to CAD in patients with type-2 diabetes
    Tharmarajan Ramprasath
    Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
    Biochem Biophys Res Commun 407:49-53. 2011
  6. ncbi Combined effects of isothiocyanate intake, glutathione S-transferase polymorphisms and risk habits for age of oral squamous cell carcinoma development
    Lee Peng Karen-Ng
    Oral Cancer Research and Coordinating Centre OCRCC, Kuala Lumpur, Malaysia
    Asian Pac J Cancer Prev 12:1161-6. 2011
  7. ncbi Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk
    Jordi To-Figueras
    Toxicology Unit, ORL Unit, Hospital Clinic, IDIBAPS, Ciutat Sanitaria de Bellvitge, Departament de Salut Publica, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Cancer Lett 187:95-101. 2002
  8. ncbi A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinoma
    Seamus J Murphy
    Department of Medical Genetics, Queen s University Belfast, Royal Group of Hospitals, Grosvenor Road, Belfast, Ireland
    Carcinogenesis 28:1323-8. 2007
  9. doi A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers
    Shanbeh Zienolddiny
    Section of Toxicology, Department of Biological and Chemical Work Environment, National Institute of Occupational Health N 0033, Oslo, Norway
    Carcinogenesis 29:1164-9. 2008
  10. ncbi Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus
    T Wang
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 276:20999-1003. 2001

Research Grants

  1. FGF: A Mechanism of Acquired Multidrug Resistance
    JESSIE AU; Fiscal Year: 2005
  2. Ozone Cardiovascular Effects in Genetically Susceptible People
    MARK WALTER FRAMPTON; Fiscal Year: 2012
  3. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
  4. Influence of human gene variants on the effects of developmental MeHg exposure
    Michael J Carvan; Fiscal Year: 2010
  5. Beverly H Koller; Fiscal Year: 2014
  6. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010
  7. Cardioprotective Mechanisms of Glutathione S-transferase P
    DANIEL JOSEPH CONKLIN; Fiscal Year: 2012
  8. Mohammad H Rahbar; Fiscal Year: 2016
  9. Albert van Der Vliet; Fiscal Year: 2016
  10. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    WILLIAM GEORGE NELSON; Fiscal Year: 2012

Detail Information

Publications343 found, 100 shown here

  1. ncbi GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking
    Joachim Schneider
    Priv Doz Dr med Joachim Schneider, Institut und Poliklinik für Arbeits und Sozialmedizin, der Justus Liebig Universität, Aulweg 129 III, D 35385 Giessen, Germany
    Cancer Lett 208:65-74. 2004
    The impact of genetic polymorphisms in GSTM1, GSTP1 or GSTT1 on susceptibility to lung cancer has received particular interest since these enzymes play a central role in detoxification of major classes of tobacco carcinogens...
  2. ncbi Polymorphisms of GSTT1 and related genes in head and neck cancer risk
    Adam J Evans
    Division of Hematology and Medical Oncology, Oregon Health and Science University, Mail Code L586, Portland, Oregon 97201, USA
    Head Neck 26:63-70. 2004
    ..We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC)...
  3. ncbi Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway
    Halla Skuladottir
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Lung Cancer 48:187-99. 2005
    ..demographic and lifestyle characteristics, and polymorphisms in following genotypes were determined GSTM1, GSTM3, GSTP1, GSTT1, GPX1, MPO, NQO1 and NAT2...
  4. doi Glutathione S-transferase M1, T1, and P1 polymorphisms and ovarian cancer risk: a meta-analysis
    Konstantinos P Economopoulos
    School of Medicine, National University of Athens, Athens, Greece
    Int J Gynecol Cancer 20:732-7. 2010
    ..studies have examined whether GST polymorphisms (GSTM1 null/present genotype, GSTT1 null/present genotype, and GSTP1 Ile105Val) represent risk factors for ovarian cancer, as they all may denote reduced enzyme activity...
  5. doi Potential risk modifications of GSTT1, GSTM1 and GSTP1 (glutathione-S-transferases) variants and their association to CAD in patients with type-2 diabetes
    Tharmarajan Ramprasath
    Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
    Biochem Biophys Res Commun 407:49-53. 2011
    ..Glutathione S-transferases (GSTM1, GSTT1 and GSTP1) are known for their broad range of detoxification and in the metabolism of xenobiotics...
  6. ncbi Combined effects of isothiocyanate intake, glutathione S-transferase polymorphisms and risk habits for age of oral squamous cell carcinoma development
    Lee Peng Karen-Ng
    Oral Cancer Research and Coordinating Centre OCRCC, Kuala Lumpur, Malaysia
    Asian Pac J Cancer Prev 12:1161-6. 2011
    ..Peripheral blood lymphocytes were obtained for genotyping of GSTM1, GSTT1 and GSTP1 using PCR multiplex and PCR-RFLP...
  7. ncbi Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk
    Jordi To-Figueras
    Toxicology Unit, ORL Unit, Hospital Clinic, IDIBAPS, Ciutat Sanitaria de Bellvitge, Departament de Salut Publica, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Cancer Lett 187:95-101. 2002
    ..gene (EPHX1, 113Tyr-->113His, 139His-->139Arg) and four glutathione S-transferase genes (GSTM1, GSTM3, GSTP1, GSTT1) were genotyped in a group of patients with larynx cancer (N=204) and in a group of healthy controls (N=203)..
  8. ncbi A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinoma
    Seamus J Murphy
    Department of Medical Genetics, Queen s University Belfast, Royal Group of Hospitals, Grosvenor Road, Belfast, Ireland
    Carcinogenesis 28:1323-8. 2007
    ..Several SNPs spanning the genes for glutathione S-transferase P1 (GSTP1), manganese superoxide dismutase (MnSOD) and glutathione peroxidase 2 (GPX2) were genotyped using multiplex ..
  9. doi A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers
    Shanbeh Zienolddiny
    Section of Toxicology, Department of Biological and Chemical Work Environment, National Institute of Occupational Health N 0033, Oslo, Norway
    Carcinogenesis 29:1164-9. 2008
    ..significant associations with multiple SNPs in the phase II genes ALDH2, COMT, EPHX1, SOD2, NAT1, NAT2, GSTM3, GSTP1, GSTT2 and MPO were also found...
  10. ncbi Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus
    T Wang
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 276:20999-1003. 2001
    ..pathways are regulated endogenously in part by protein-protein interactions with glutathione S-transferase P1-1 (GSTP1-1) ()...
  11. pmc Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties
    B Mannervik
    Proc Natl Acad Sci U S A 82:7202-6. 1985
    ..It is suggested that the similarities of the isoenzymes in a class reflect evolutionary relationships and that the classification applies generally...
  12. ncbi Relationship between glutathione S-transferase M1, P1 and T1 polymorphisms and early onset prostate cancer
    Z Kote-Jarai
    Section of Cancer Genetics, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK
    Pharmacogenetics 11:325-30. 2001
    ..The GSTP1 gene has a polymorphism at codon 105 resulting in an Ile to Val substitution which consequently alters the ..
  13. ncbi Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer
    Mia Hashibe
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 12:1509-17. 2003
    Sequence variation in the GSTM1, GSTT1, GSTP1, and CYP1A1 genes may potentially alter susceptibility to head and neck cancers, although evidence from previous studies has not been consistent...
  14. pmc Association of GSTP1 Ile105Val polymorphism and risk of head and neck cancers: a meta-analysis of 28 case-control studies
    Juntian Lang
    Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China
    PLoS ONE 7:e48132. 2012
    The Glutathione S-transferase P1 (GSTP1) polymorphism have been considered a risk modifier for developing head and neck cancer (HNC) in many studies; however, the results of such studies are inconsistent...
  15. ncbi Polymorphisms of the glutathione S-transferase P1 gene and head and neck cancer susceptibility
    Michael B Oude Ophuis
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Head Neck 25:37-43. 2003
    ..Genetic polymorphisms in glutathione S-transferases (GSTs) often result in altered detoxification, which may contribute to individual susceptibility to HNSCC...
  16. ncbi [Polymorphism of glutathione-S-transferase M1 and P1 genes in patients with cystic fibrosis and chronic respiratory tract diseases]
    G F Korytina
    Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, 45054 Russia
    Genetika 40:401-8. 2004
    Polymorphism of GSTM1 and GSTP1 genes was studied in patients with cystic fibrosis (CF) and chronic bronchopulmonary diseases (CBPD) living in Bashkortostan...
  17. ncbi Lung cancer susceptibility and polymorphisms of glutathione-S-transferase genes in Hong Kong
    Moira Chan-Yeung
    Department of Medicine, Queen Mary Hospital, The University of Hong Kong, SAR, PR China
    Lung Cancer 45:155-60. 2004
    To study the potential role of genetic polymorphisms of glutathione-S-transferases GSTM1, GSTT1 and GSTP1 in susceptibility to lung cancer in Hong Kong Chinese.
  18. ncbi [Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China]
    Ge Yu Liang
    School of Public Health, Southeast University, Nanjing 210009, China
    Yi Chuan 26:584-8. 2004
    ..The polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1, mEH and NQO1 genes were analyzed by PCRjRFLP assay...
  19. ncbi Polymorphisms in glutathione-related genes affect methylmercury retention
    Hipolito M Custodio
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Arch Environ Health 59:588-95. 2004
    ..concentration (EryHg), plasma polyunsaturated fatty acids (PPUFA), and genotype for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 365 individuals...
  20. ncbi Glutathione S-transferase polymorphisms and oral cancer: a case-control study in Rio de Janeiro, Brazil
    Ana Hatagima
    Departamento de Genetica, Laboratório de Genética Humana IOC FIOCRUZ, Pavilhão Leônidas Deane 6 Andar Sala 611, Avenida Brasil, 4365 Manguinhos, Rio de Janeiro, Rio de Janeiro 21045 900, Brazil
    Oral Oncol 44:200-7. 2008
    This study evaluates the influence of genetic polymorphisms at GSTM1, GSTT1 and GSTP1 gene loci on oral cancer susceptibility among Brazilians from Rio de Janeiro...
  21. pmc Polymorphisms in glutathione S-transferase genes increase risk of prostate cancer biochemical recurrence differentially by ethnicity and disease severity
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    Cancer Causes Control 20:1915-26. 2009
    ....
  22. doi Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer
    Mu Kuan Chen
    Department of Otorhinolaryngology Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan
    Head Neck 32:1079-87. 2010
    ..The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk...
  23. ncbi No association between the I105V polymorphism of the glutathione S-transferase P1 gene (GSTP1) and prostate cancer risk: a prospective study
    T F Shepard
    The Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 9:1267-8. 2000
  24. ncbi Polymorphisms of GSTP1 and related genes and prostate cancer risk
    T M Beer
    Division of Hematology and Medical Oncology, Oregon Health Sciences University, Oregon, USA
    Prostate Cancer Prostatic Dis 5:22-7. 2002
    Glutathione S-transferase P1 (GSTP1) is markedly downregulated in prostate cancer and prostatic intraepithelial neoplasia compared to normal prostate tissue...
  25. pmc Associations of tumor necrosis factor G-308A with childhood asthma and wheezing
    Yu Fen Li
    Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 173:970-6. 2006
    ..produces oxidative stress, increased airway TNF, and inflammation, the associations of the -308 TNF polymorphism with asthma may vary by ozone exposure and variants of oxidant defense genes glutathione-S-transferase (GST) M1 and GSTP1.
  26. ncbi Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk
    Sang Ah Lee
    Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Clin Nutr 87:753-60. 2008
    ..Cruciferous vegetables are the primary source of isothiocyanates and other glucosinolate derivatives that are known to induce phase II detoxifying enzymes, including glutathione S-transferases (GSTs)...
  27. pmc Associations between multiple environmental exposures and Glutathione S-Transferase P1 on persistent wheezing in a birth cohort
    Kathy T Schroer
    Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Pediatr 154:401-8, 408.e1. 2009
    ....
  28. doi Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinoma
    Yen Chung Chen
    National Yang Ming University School of Medicine, Taipei, Taiwan
    Cancer Sci 101:530-5. 2010
    Glutathione S-transferase P1 (GSTP1) participates in detoxification of potentially genotoxic compounds that may alter the efficacy and toxicity of platinum-based chemotherapy...
  29. doi Dietary glucosinolate intake, polymorphisms in selected biotransformation enzymes, and risk of prostate cancer
    Astrid Steinbrecher
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 19:135-43. 2010
    ..between glucosinolate intake and prostate cancer risk is modified by polymorphisms in GSTT1, GSTM1, GSTA1, GSTP1, or NOQ1 genes...
  30. doi Polymorphisms of glutathione-S-transferase genes and the risk of aerodigestive tract cancers in the Northeast Indian population
    Dhirendra Singh Yadav
    Institute of Pathology, Indian Council of Medical Research ICMR, New Delhi, India
    Genet Test Mol Biomarkers 14:715-23. 2010
    ..This study was done to explore the possibility of phase II metabolic enzymes being responsible for the high prevalence of cancers in this region of India...
  31. doi Methylation of tumor associated genes in tissue and plasma samples from liver disease patients
    Hong Chang
    Laboratory of Molecular and Experimental Pathology, Key Laboratory of Animal Models and Human Disease Mechanism, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    Exp Mol Pathol 85:96-100. 2008
    ..The hypermethylation frequency of GSTP1 and RASSF1A showed significant difference between HCCs and liver cirrhosis with or without HBV infection (P<0...
  32. ncbi Glutathione S-transferase M1, T1, and P1 polymorphisms and survival among lung cancer patients
    Carol Sweeney
    Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Cancer Epidemiol Biomarkers Prev 12:527-33. 2003
    ..The presence of the GSTM1 and GSTT1 genes were assayed by multiplex PCR. Genotype at the GSTP1 Ile(105)Val substitution was determined by PCR and oligonucleotide ligation assay...
  33. ncbi Maternal and fetal single nucleotide polymorphisms in the epoxide hydrolase and gluthatione S-transferase P1 genes are not associated with pre-eclampsia in the Coloured population of the Western Cape, South Africa
    G S Gebhardt
    Department of Obstetrics and Gynaecology, University of Stellenbosch, South Africa
    J Obstet Gynaecol 24:866-72. 2004
    ..and control mother - infant pairs with uncomplicated pregnancy outcome (n = 45) were analysed for the EPHX and GSTP1 polymorphisms by polymerase chain reaction amplification and restriction enzyme digestion...
  34. ncbi Association of CYP17, GSTP1, and PON1 polymorphisms with the risk of prostate cancer
    Cinzia Antognelli
    Experimental Medicine Department, University of Perugia, Perugia, Italy
    Prostate 63:240-51. 2005
    ..We have undertaken a case-control study in order to elucidate the association between polymorphisms in some metabolizing genes with the risk of prostate cancer (PCa)...
  35. ncbi CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study
    A Leichsenring
    Laboratório de Citogenética Humana e Oncogenética, Departamento de Genetica, Universidade Federal do Parana, 81531 970 Curitiba, PR, Brazil
    Braz J Med Biol Res 39:1569-74. 2006
    CYP1A1 and GSTP1 polymorphisms have been associated with a higher risk to develop several cancers, including oral squamous cell carcinoma (OSCC), which is closely related to tobacco and alcohol consumption...
  36. pmc Association of the GSTP1 and NQO1 polymorphisms and head and neck squamous cell carcinoma risk
    Chang Gun Cho
    Department of Otorhinolaryngology Head and Neck Surgery, Dongguk University International Hospital, Goyang, Korea
    J Korean Med Sci 21:1075-9. 2006
    The GSTP1 and NQO1 have been reported to be associated with an increased risk for smoking related head and neck squamous cell carcinoma (HNSCC)...
  37. ncbi Association of genetic polymorphisms in glutathione S-transferases and susceptibility to head and neck cancer
    Madhu Singh
    Developmental Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Mutat Res 638:184-94. 2008
    Polymorphism in glutathione S-transferase (GST) genes (GSTM1, GSTT1 and GSTP1) and interaction with environmental factors such as tobacco (smoking or chewing) and alcohol on susceptibility to head and neck squamous cell carcinoma (HNSCC) ..
  38. ncbi Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells
    Jila Bakker
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    J Biol Chem 277:22573-80. 2002
    ..of human hepatocellular carcinoma (HCC), the CpG island encompassing the pi-class glutathione S-transferase gene (GSTP1) becomes hypermethylated...
  39. ncbi Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure
    P Piirilä
    Departments of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 11:437-45. 2001
    ..We examined whether polymorphisms in the GSTM1, GSTM3, GSTP1 and GSTT1 genes modify allergic responses to diisocyanate exposure...
  40. doi An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a HuGE review
    Zengnan Mo
    Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People s Republic of China
    Prostate 69:662-88. 2009
    It has been postulated that individuals with GSTM1, GSTT1 deficiency and, GSTP1 (105Ile/Val transition) have increased susceptibility to carcinogens and are more likely to develop prostate cancer...
  41. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19 and CYP2D6), glutathione S-transferase (GSTM1, GSTP1 and GSTT1), sulfotransferase (SULT1A1 and SULT1A2), N-acetyl transferase 2 (NAT2), NAD(P)H:quinone oxidoreductase (..
  42. doi GSTP1 determines cis-platinum cytotoxicity in gastric adenocarcinoma MGC803 cells: regulation by promoter methylation and extracellular regulated kinase signaling
    Ye Zhang
    Department of Medical Oncology bMedical Respiratory, The First Hospital, China Medical University, Shenyang, China
    Anticancer Drugs 20:208-14. 2009
    ..Glutathione S-transferase-pi (GSTP1) belongs to a supergene family of detoxifying enzymes involved in the prevention of DNA damage and subsequent ..
  43. doi Genetic background of lead and mercury metabolism in a group of medical students in Austria
    Claudia Gundacker
    Medical University of Vienna, Center for Public Health, Lab Ecotoxicology, Waehringer Strasse 10, A 1090 Vienna, Austria
    Environ Res 109:786-96. 2009
    ..There is increasing evidence that certain genetic polymorphisms modify lead and mercury toxicokinetics. This called for analysis of further candidate genes...
  44. ncbi Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population
    Baorui Liu
    Department of Oncology, Drum Tower Hospital Affiliated to Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, China
    Eur J Hum Genet 15:1049-53. 2007
    ..pigmentosum group D (XPD), X-ray repair cross complementing group 1 (XRCC1) and glutathione S-transferase P1 (GSTP1) predicted overall survival in gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese ..
  45. ncbi Association of GSTP1 polymorphism and survival for esophageal cancer
    Jang Ming Lee
    Department of Surgery and Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    Clin Cancer Res 11:4749-53. 2005
    ..The clinical significance of this variation is still puzzling. We investigated whether genetic polymorphisms of GST including GSTP1, GSTM1, and GSTT1 affect survival among esophageal cancer patients.
  46. ncbi Glutathione S-transferase M1, T1 and P1 polymorphisms: susceptibility and outcome in lung cancer patients
    Leelakumari Sreeja
    Division of Cancer Research, Regional Cancer Centre, Trivandrum 695011, India
    J Exp Ther Oncol 7:73-85. 2008
    ..We investigated whether genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes modulated lung cancer risk and affect survival among lung cancer patients...
  47. ncbi Lack of association between glutathione S-transferase P1 polymorphism and COPD in Koreans
    J J Yim
    Department of Internal Medicine and Lung Institute, Clinical Research Institute, Seoul National University College of Medicine, 28 Yongdon, Chongno Gu, Seoul 110 744, South Korea
    Lung 180:119-25. 2002
    ..The purpose of this study was to determine whether polymorphism of GSTP1 gene is linked to a genetic susceptibility to COPD...
  48. ncbi Polymorphism of glutathione S-transferase T1, M1 and P1 genes in a Shanghai population: patients with occupational or non-occupational bladder cancer
    Qing wen Ma
    Sino German Laboratory of Toxicology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 225 Chongqing Rd S, Shanghai 200025, China
    Biomed Environ Sci 15:253-60. 2002
    ....
  49. ncbi Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan
    Pinpin Lin
    Institute of Toxicology, Chung Shan Medical University, No 110, Sec 1, Chien Kuo N Rd, Taichung 402, Taiwan, ROC
    Lung Cancer 40:123-9. 2003
    ..association of three genetic polymorphisms, NAD(P)H quinone oxidoreductase (NQO1), Glutathione-S-transferase P1 (GSTP1), and manganese superoxide dismutase (MnSOD), with lung cancer risk in 198 cases and 332 controls in Taiwan...
  50. ncbi GSTP1 and GSTA1 polymorphisms interact with cruciferous vegetable intake in colorectal adenoma risk
    Mariken J Tijhuis
    Division of Human Nutrition, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
    Cancer Epidemiol Biomarkers Prev 14:2943-51. 2005
    ..The GSTM1 and GSTT1 deletion polymorphisms, and the single nucleotide polymorphisms in GSTP1 (A313G) and in GSTA1 (C-69T) were assessed among 746 cases who developed colorectal adenomas and 698 endoscopy-..
  51. ncbi [A molecular epidemiological study on the relationship between the polymorphism of GSTP1 and susceptibility to gastric cancer in northern Chinese]
    Ye Zhang
    Cancer Institute of the First Affiliated Hospital of China Medical University, Shenyang, China
    Yi Chuan 29:293-300. 2007
    We analyzed the distribution of glutathione-S-transferase P1 gene (GSTP1) polymorphism in a population from northern China and the relationship between the polymorphic BsmAI site in its exon 5 and gastric cancer susceptibility and ..
  52. ncbi Ile105Val GSTP1 polymorphism and susceptibility to colorectal carcinoma in Bulgarian population
    Tatyana Vlaykova
    Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
    Int J Colorectal Dis 22:1209-15. 2007
    ..A member of the glutathione-S-transferase (GST) family, GSTP1, is an important candidate for involvement in susceptibility to carcinogen-associated CRC...
  53. doi Recombinant protein glutathione S-transferases P1 attenuates inflammation in mice
    Lan Luo
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China
    Mol Immunol 46:848-57. 2009
    We have reported that intracellular glutathione S-transferases P1 (GSTP1) suppresses LPS (lipopolysaccharide)-induced excessive production of pro-inflammatory factors by inhibiting LPS-stimulated MAPKs (mitogen-activated protein kinases) ..
  54. pmc MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer
    Ning Sun
    Clinical Medicine College of Southeast University, and Zhongda Hospital, 210009, Nanjing, Jiangsu, China
    Cancer Chemother Pharmacol 65:437-46. 2010
    ..We hypothesize that genetic polymorphisms in metabolising enzymes gene GSTP1 (glutathione S-transferase P1), and MRP2 (multidrug resistance-associated protein 2) (ABCC2), which result in ..
  55. doi Genetic polymorphisms of GSTP1 and XRCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC) patients
    Fei Zhou
    Department of Oncology, the Affiliated Hospital of Medical College, Qing Dao University, Qingdao, Shandong Province, China
    Swiss Med Wkly 141:w13275. 2011
    Platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of GSTP1 and XRCC1 involved in glutathione metabolic and DNA repair pathways may explain inter individual differences in chemosensitivity and clinical ..
  56. ncbi Promoter hypermethylation in circulating blood cells identifies prostate cancer progression
    Morgan Roupret
    Institute for Cancer Studies, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Int J Cancer 122:952-6. 2008
    ..more hypermethylation was detected in the diagnostic sample from the patients with cancer than in controls for GSTP1, RASSF1 alpha, APC and RAR beta (p < 0.0001)...
  57. doi Association study between glutathione S-transferase GST-M1, GST-T1, and GST-P1 polymorphisms and tardive dyskinesia
    Seung Gul Kang
    Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
    Hum Psychopharmacol 24:55-60. 2009
    ..In the present study, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes can influence susceptibility to TD in patients with schizophrenia...
  58. ncbi Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia
    Martin Yuille
    Academic Department of Haematology and Cytogenetics, and the Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Blood 99:4216-8. 2002
    ..GSTM1, GSTT1, and GSTP1 genotypes were determined in 138 patients and 280 healthy individuals...
  59. ncbi Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells
    Xiaohui Lin
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 63:498-504. 2003
    b>GSTP1, encoding the pi-class glutathione S-transferase, is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast...
  60. ncbi Genetic susceptibility and dietary patterns in lung cancer
    Ya Yu Tsai
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Lung Cancer 41:269-81. 2003
    ..Smokers who were not homozygous for the most common GSTP1 allele and had a healthy dietary pattern were at significantly lower risk than smokers who were homozygous for the ..
  61. doi Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial
    Michael S Braun
    Oncology and Clinical Research and Pathology and Tumour Biology Sections, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
    J Clin Oncol 27:5519-28. 2009
    ..Predicting efficacy and toxicity could potentially allow individualization of cancer therapy. We investigated putative pharmacogenetic markers of chemotherapy toxicity in a large randomized trial...
  62. pmc The COPD genetic association compendium: a comprehensive online database of COPD genetic associations
    Peter J Castaldi
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Hum Mol Genet 19:526-34. 2010
    ..Quantitative meta-analysis identified four variants in GSTM1, TGFB1, TNF and SOD3 that show statistically significant evidence of association with COPD susceptibility...
  63. ncbi Glutathione S-transferases mu 1, theta 1, pi 1, alpha 1 and mu 3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans
    Carmen Martinez
    Department of Pharmacology and Psychiatry, University of Extremadura, Badajoz, Spain
    Pharmacogenomics 7:711-8. 2006
    ..This study aimed to elucidate the influence of several GST polymorphisms on colorectal and gastric cancer risk...
  64. ncbi Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma
    C Steinhoff
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Arch Toxicol 74:521-6. 2000
    Genotype distributions for GSTP1, GSTM1, and GSTT1 were determined in 91 patients with prostatic carcinoma and 135 patients with bladder carcinoma and compared with those in 127 abdominal surgery patients without malignancies...
  65. pmc Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia
    J M Allan
    Molecular Epidemiology Unit, Academic Unit of Epidemiology and Health Services Research, School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom
    Proc Natl Acad Sci U S A 98:11592-7. 2001
    ..Functional polymorphisms exist in at least three genes that encode GSTs, including GSTM1, GSTT1, and GSTP1. We hypothesize, therefore, that polymorphisms in genes that encode GSTs alter susceptibility to chemotherapy-..
  66. pmc Simultaneous identification of GSTP1 Ile105-->Val105 and Ala114-->Val114 substitutions using an amplification refractory mutation system polymerase chain reaction assay: studies in patients with asthma
    A Hemmingsen
    Centre for Cell and Molecular Medicine, Keele University, North Staffordshire Hospital, Staffordshire, England, UK
    Respir Res 2:255-60. 2001
    The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress...
  67. ncbi N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk
    Harriet Wikman
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 12:227-33. 2002
    ..of diisocyanate-induced ill effects, both separately and in combination with the previously examined GSTM1, GSTM3, GSTP1 and GSTT1 genotypes...
  68. ncbi Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates
    Cristina E Mapp
    Department of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Ferrara, Ferrara, Italy
    J Allergy Clin Immunol 109:867-72. 2002
    Polymorphism at the pi class glutathione-S-transferase locus (GSTP1) is associated with allergen-induced asthma and related phenotypes.
  69. ncbi Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer
    Jan Stoehlmacher
    Department of Medical Oncology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA 90033, USA
    J Natl Cancer Inst 94:936-42. 2002
    ..study, we investigated associations between common polymorphisms in genes for several GST subclasses (GSTP1, GSTT1, GSTM1) and survival of patients with metastatic colorectal cancer receiving 5-fluorouracil (5-FU)/..
  70. ncbi Expression of glutathione s-transferase pi in benign mucosa, Barrett's metaplasia, and adenocarcinoma of the esophagus
    Rakesh K Chandra
    Department of Otolaryngology Head and Neck Surgery, Northwestern University Medical School, 303 E Chicago Ave, Searle Bldg 12 561, Chicago, Illinois 60611, USA
    Head Neck 24:575-81. 2002
    ..Glutathione s-transferase pi (GSTpi) is an enzyme that provides cellular protection against redox-mediated damage by free radicals, which have been implicated in carcinogenesis...
  71. ncbi Glutathione S-transferase polymorphisms in thyroid cancer patients
    Alba Hernandez
    Grup de Mutagenesi, Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Cancer Lett 190:37-44. 2003
    ..investigation has been conducted to detect the possible association between polymorphism at the GSTM1, GSTT1 and GSTP1 genes and thyroid cancer incidence...
  72. ncbi Association of genetic polymorphisms of glutathione-S-transferase genes (GSTM1, GSTT1 and GSTP1) with familial prostate cancer risk in a Japanese population
    Haruki Nakazato
    Department of Urology, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi, 371 8511, Japan
    Anticancer Res 23:2897-902. 2003
    ..The genetic polymorphisms of GSTM1, GSTT1 and GSTP1 genes have been studied to estimate the relative risk of various cancers...
  73. ncbi Glutathion S transferase pi indicates chemotherapy resistance in breast cancer
    Fengxi Su
    Department of Surgery, Sun Yat Sen Memorial Hospital, Sun Yat sen University of Medical Science, Guangzhou, People s Republic of China
    J Surg Res 113:102-8. 2003
    ....
  74. ncbi Glutathione pathway genes and lung cancer risk in young and old populations
    P Yang
    Division of Epidemiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Carcinogenesis 25:1935-44. 2004
    ..Using PCR amplification of genomic DNA, polymorphic markers for gammaGCS, GPX1, GSTP1 (I105V and A114V), GSTM1 and GSTT1 were genotyped...
  75. ncbi Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics
    Regislaine Valéria Burim
    Department of Genetics and Department of Internal Medicine, Faculty of Medicine of Ribeirao Preto, Sao Paulo University, Av Bandeirantes 3900, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Mutagenesis 19:291-8. 2004
    ..The enzymes GSTM1, GSTT1, GSTP1, CYP1A1 and CYP2E1 are involved in the bioactivation and detoxification of a variety of xenobiotics present in ..
  76. ncbi The relationship of the human glutathione S-transferase P1 polymorphism and chemotherapeutic sensitivity in head and neck squamous carcinoma
    Shinobu Kimura
    Department Otorhinolaryngology, Yokohama City University School of Medicine, Kanazawaku, Yokohama City, Kanagawa prefecture 236 0023, Japan
    Int J Mol Med 14:185-9. 2004
    b>GSTP1, which encodes GSTPi, has a polymorphic site at codon 105 (exon 5), where an adenosine-to-guanine (A-G) transition causes an isoleucine-to-valine substitution (I105V)...
  77. ncbi Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk
    E M J van der Logt
    Department of Gastroenterology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Carcinogenesis 25:2407-15. 2004
    ..enzymes UDP-glucuronosyltransferase UGT1A1, UGT1A6, UGT1A7 and UGT1A8, and glutathione S-transferase GSTA1, GSTM1, GSTP1 and GSTT1. Patients and controls were all of Caucasian origin...
  78. ncbi GSTM1, GSTT1 and GSTP1 polymorphisms, environmental tobacco smoke exposure and risk of lung cancer among never smokers: a population-based study
    A S Wenzlaff
    Population Studies and Prevention Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Carcinogenesis 26:395-401. 2005
    ..Polymorphisms within the GSTM1, GSTT1 and GSTP1 genes, coding for enzymes with deficient or reduced activity, have been studied as potential modifiers of lung ..
  79. ncbi Glutathione-S-transferase gene polymorphisms (GSTT1, GSTM1, GSTP1) as increased risk factors for asthma
    Lulufer Tamer
    Deparment of Biochemistry, Medical Faculty, Mersin University, Mersin, Turkey
    Respirology 9:493-8. 2004
    ..In the present study, the hypothesis that polymorphisms in the GSTT1, GSTM1 and GSTP1 genes are associated with atopic and nonatopic asthma was examined.
  80. ncbi Association of GSTM1, GSTT1, and GSTP1 gene polymorphisms with the risk of prostate cancer: a meta-analysis
    Christos Ntais
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Cancer Epidemiol Biomarkers Prev 14:176-81. 2005
    ..cases and 2,625 controls), 10 studies with GSTT1 genotyping (1,965 cases and 2,554 controls), and 12 studies with GSTP1 genotyping (2,528 cases and 3,076 controls). The random effects odds ratio was 1...
  81. ncbi Association of NAT and GST polymorphisms with non-Hodgkin's lymphoma: a population-based case-control study
    Brian C H Chiu
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 4402, USA
    Br J Haematol 128:610-5. 2005
    ..Individuals with GSTP1 Val homozygotes had non-significant excessive risk of marginal zone lymphoma (OR = 1.8; 0.6-5...
  82. ncbi Association study of Glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations
    Renate Nickel
    Department of Pediatric Pneumonology and Immunology, Charite, Humboldt University, Berlin, Germany
    Pediatr Allergy Immunol 16:539-41. 2005
    Glutathione S-Transferase P1 (GSTP1) is an important enzyme in the detoxification of products of oxidative stress...
  83. ncbi Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival
    A Beeghly
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Gynecol Oncol 100:330-7. 2006
    ..GSTM1, GSTT1, and GSTP1 genotypes were evaluated for their role in ovarian cancer treatment and survival.
  84. pmc Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)--novel predictors for response and survival in gastric cancer patients
    E Goekkurt
    Department of Haematology and Oncology, University Hospital Hamburg Eppendorf, University of Hamburg, Germany
    Br J Cancer 94:281-6. 2006
    ..9;8.1). Overall response rate was 26%. Patients possessing the glutathione S-transferase P1-105 Valine/Valine (GSTP1-105VV) genotype showed a response rate of 67% compared to 21% in patients harbouring at least one GSTP1-105 ..
  85. ncbi Cytogenetic damage and genetic variants in the individuals susceptible to arsenic-induced cancer through drinking water
    Pritha Ghosh
    Indian Institute of Chemical Biology, Kolkata, and West Bank Hospital, Howrah, India
    Int J Cancer 118:2470-8. 2006
    ..Identification of null mutations in GSTT1 and GSTM1 genes were carried out by PCR amplification. GSTP1 SNPs, implicated in susceptibility to various cancers, were assessed by PCR-RFLP method...
  86. ncbi Dietary selenium intake and genetic polymorphisms of the GSTP1 and p53 genes on the risk of esophageal squamous cell carcinoma
    Lin Cai
    Department of Epidemiology, School of Public Health, University of California at Los Angeles, 71 225 CHS, Box 951772, 650 Charles Young Drive, Los Angeles, California 90095 1772, USA
    Cancer Epidemiol Biomarkers Prev 15:294-300. 2006
    ..We studied the joint effects of dietary selenium and the GSTP1 and p53 polymorphisms on ESCC risk in a population-based case-control study with 218 ESCC cases and 415 controls ..
  87. ncbi [Transferase S-glutathione class pi gene (GSTP1) polymorphism in thyroid cancer patients]
    Paweł Marciniak
    Department of Biochemistry and Biotechnology, Agricultural University, Poznan, Poland
    Endokrynol Pol 57:509-15. 2006
    One of the potential genes which can increase the risk of cancer is GSTP1 gene. It encodes enzyme called glutathione S-transferase pi class, which is involved in the detoxification of a variety of potential carcinogenic compounds...
  88. ncbi Hypermethylation of the CpG islands in the promoter region flanking GSTP1 gene is a potential plasma DNA biomarker for detecting prostate carcinoma
    Cheng Keng Chuang
    Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Lin Kou, Taiwan
    Cancer Detect Prev 31:59-63. 2007
    ..To investigate the possibility of identifying DNA hypermethylation in the circulation of prostate cancer patients...
  89. ncbi ABCB1 and GST polymorphisms associated with TP53 status in breast cancer
    Silje H Nordgard
    Department of Genetics, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Pharmacogenet Genomics 17:127-36. 2007
    ..The goal of this study was to characterize the genetic variation in the ABCB1, GSTM1, GSTT1 and GSTP1 genes, as well as the haplotype structure in the ABCB1 gene.
  90. ncbi Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy
    Annamaria Ruzzo
    Institute of Biochemistry G Fornaini, University of Urbino, Urbino, Italy
    J Clin Oncol 25:1247-54. 2007
    ....
  91. ncbi Chromatin changes on the GSTP1 promoter associated with its inactivation in prostate cancer
    Steven T Okino
    Department of Urology, San Francisco Veterans Affairs Medical Center and the University of California San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 46:839-46. 2007
    ..In prostate tumors, expression of GST pi (encoded by GSTP1) is frequently lost because of promoter hypermethylation...
  92. ncbi Associations of glutathione S-transferase P1, M1, and environmental tobacco smoke with wheezing illness in school children
    Y L Lee
    Department of Occupational and Environmental Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Allergy 62:641-7. 2007
    ..We hypothesized that the GSTP1 and GSTM1 genotypes could modify the effects of household environmental tobacco smoke (ETS) on childhood wheezing ..
  93. ncbi Population pharmacokinetics of melphalan and glutathione S-transferase polymorphisms in relation to side effects
    A Kuhne
    Department of Clinical Pharmacology, Georg August University, Gottingen, Germany corrected
    Clin Pharmacol Ther 83:749-57. 2008
    ..In addition, we studied glutathione S-transferase GSTM1, GSTT1, and GSTP1 polymorphisms in relation to adverse events...
  94. ncbi Glutathione S-transferase genotype increases risk of progression from bronchial hyperresponsiveness to asthma in adults
    M Imboden
    IInstitutes of Social and Preventive Medicine and Surgical Pathology, Cancer Registry Molecular Epidemiology, University of Zurich, Zurich, Switzerland
    Thorax 63:322-8. 2008
    ..Bronchial hyperresponsiveness (BHR) and variation in glutathione S-transferase (GST) genes have been associated with asthma risk. The relationship of these two risk factors with adult onset asthma in the general population was investigated...
  95. pmc Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease
    Erik Melen
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 116:1077-84. 2008
    ..Air pollutants may induce airway inflammation and sensitization due to generation of reactive oxygen species. The genetic background to these mechanisms could be important effect modifiers...
  96. doi GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, National University of Athens, Athens, Greece
    Breast Cancer Res Treat 121:195-202. 2010
    ..isoenzymes; studies have principally examined mu-1 (GSTM1: null/present), theta-1 (GSTT1: null/present) and pi-1 (GSTP1 Ile105Val) gene polymorphisms concerning breast cancer risk...
  97. doi GSTP1 I105V polymorphism and susceptibility to colorectal cancer in Kashmiri population
    A Syed Sameer
    Department of Immunology and Molecular Medicine, Sher I Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India
    DNA Cell Biol 31:74-9. 2012
    The glutathione S-transferase (GST) enzyme encoded by the GSTP1 gene is one of the critical enzymes involved in detoxification of carcinogens...
  98. doi Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population
    Q Qadri
    Department of Immunology and Molecular Medicine, Sher I Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India
    Genet Mol Res 10:3038-45. 2011
    Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway...
  99. ncbi Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors
    J A Moscow
    Medicine Branch, National Cancer Institute, Bethesda, Maryland 20892
    Cancer Res 49:1422-8. 1989
    ..In addition, comparison of paired specimens from the same patient indicated that GST pi expression was increased in many tumors relative to matched normal tissue...
  100. ncbi The glutathione S-transferases: influence of polymorphism on cancer susceptibility
    R C Strange
    Clinical Biochemistry Research Group, School of Postgraduate Medicine, Keele University, North Staffordshire Hospital, Stoke on Trent, United Kingdom
    IARC Sci Publ . 1999
    ..have attracted particular interest, and recently identified allelic variants at the mu class GSTM3 and pi class GSTP1 loci are also putative susceptibility candidates...
  101. ncbi Eosinophil peroxidase oxidation of thiocyanate. Characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system
    M Arlandson
    Department of Internal Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 276:215-24. 2001
    ....

Research Grants63

  1. FGF: A Mechanism of Acquired Multidrug Resistance
    JESSIE AU; Fiscal Year: 2005
    ..3) Test the hytpothesis that FGF is an upstream event that triggers several known mechanisms of acquired MDR. (4) Test the hypothesis that suramin can reverse acquired MDR under in vitro and in vivo conditions. ..
  2. Ozone Cardiovascular Effects in Genetically Susceptible People
    MARK WALTER FRAMPTON; Fiscal Year: 2012
    ..Understanding the effects of ozone on the heart and circulation can help establish appropriate air pollution standards, and provide strategies to protect the most susceptible people. ..
  3. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
    ..Other common single nucleotide polymorphisms (SNPs) of interest exist in NF-E2, related factor 2 (NRF2), GSTP1, GSTT1, glutathione peroxdiase (GPX1), Heme oxygenase-1 (HO-1), and Superoxidase dismutase 2 (SOD2), theCD14 gene ..
  4. Influence of human gene variants on the effects of developmental MeHg exposure
    Michael J Carvan; Fiscal Year: 2010
    ..S-transferase pi 1, glutamate-cysteine ligase catalytic subunit, and glutamate-cysteine ligase modifier subunit (GSTP1, GCLC and GCLM, respectively) in susceptibility to MeHg-induced neurodevelopmental dysfunction using humanized ..
  5. Beverly H Koller; Fiscal Year: 2014
    ..can be grouped into eight different families, with the majority of genetic studies focused on polymorphisms in GSTP1, a member of the pi family and GSTM1 and GSTT1, members of the mu and theta families...
  6. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010
    ..In addition, we will assess the role of select polymorphisms in glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1), and their potential interactions with these heavy metals in relation to ASD...
  7. Cardioprotective Mechanisms of Glutathione S-transferase P
    DANIEL JOSEPH CONKLIN; Fiscal Year: 2012
    ..tests, transgenic (TG) and TG mice crossed with null mice with cardiac-restricted expression of human polymorphic GSTP1-1 genes will be exposed to I/R and infarction determined...
  8. Mohammad H Rahbar; Fiscal Year: 2016
    ..Furthermore, we will assess the role of select polymorphisms in GST genes (GSTM1, GSTT1, GSTP1), and their potential interactions with these OCs in relation to ASD...
  9. Albert van Der Vliet; Fiscal Year: 2016
    ..Also, based on recent studies indicating that acrolein is detoxified by glutathione S-transferase P1 (GSTP1) and by hydrogen sulfide (H2S), a newly recognized endogenous mediator produced by (homo)cysteine metabolism by ..
  10. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    WILLIAM GEORGE NELSON; Fiscal Year: 2012
    ..June 1, 2002, and renewed again April 1, 2004, has been the role of CpG island hypermethylation changes targeting GSTP1, encoding the p-class glutathione S-transferase, in the pathogenesis of prostate cancer (PCA)...
  11. Michelle Hernandez; Fiscal Year: 2014
    ..4 parts per million (ppm) ozone (O3). GSTM1 and numerous other phase II antioxidant enzymes (NQO1, GSTP1, HO-1) are regulated by the master transcription factor NF-E2- related factor 2 (NRF2)...
  12. Wen Hsiang Lee; Fiscal Year: 2014
    ..Recently, the pi isoform of glutathione S-transferase (GSTP1) has been identified as a zeaxanthin-binding protein in the human macula...
  13. Charles R Sanders; Fiscal Year: 2016
    ..Specific Aim 2b will elucidate the chemistry, kinetics, and divalent metal ion-dependence of the FosB enzymes with both BSH and the alternative substrate L-Cys. ..
  14. Protein Kinase C and GSTP1 interactions in glioma drug resistance
    Francis Ali-Osman; Fiscal Year: 2012
    ..crosstalk between a major Phase II drug metabolizing and cell signaling protein, the glutathione S-transferase P1 (GSTP1) and the serine/threonine protein kinase, PKC...
  15. Prostate Cancer Detection by Molecular Urinalysis
    Christian P Pavlovich; Fiscal Year: 2010
    ..form the cornerstones of this study: methylation of DNA at CpG islands of the pi-class glutathione-s transferase (GSTP1) promoter, a noncoding RNA "differential display 3" (DD3), and the protein alpha methylacyl CoA racemase (AMACR)...
  16. PETER WALLACE STACPOOLE; Fiscal Year: 2016
    ....
  17. Francis Ali-Osman; Fiscal Year: 2014
    ..Glutathione S-transferase P1, GSTP1, a multifunctional protein involved in phase II metabolism and in the regulation of cell signaling is frequently ..
  18. Directed evolution of fosfomycin resistance enzymes from a promiscuous progenitor
    Paul D Cook; Fiscal Year: 2010
    ....
  19. Kevin M Patrie; Fiscal Year: 2014
    ..Additionally, GSTP1-1 is the GST predominantly found in platelets...
  20. Glutathione S-Transferase Functions in Chemoprevention
    Alan Townsend; Fiscal Year: 2009
    ..these investigations with our existing single-and dual-transfected V79 cell lines that stably express human GSTP1, GSTM1, or GSTA1, alone and also in combination with human P450-1A1 or-1B1, with addition of -1A2...
  21. John A Gerlt; Fiscal Year: 2015
    ..In achieving this goal, the EFI will nucleate and enable a larger consortium of investigators working toward the goal of realizing the biomedical potential of the vast amount of sequence data provided by genome projects. ..
  22. METABOLISM AND TOXICITY OF HALOGENATED HYDROCARBONS
    MARION ANDERS; Fiscal Year: 2004
    ..Hence, DCA may also find use in the management of HT-1. It is, therefore, important to explore the mechanism by which DCA and other dihaloacetates inactivate GSTZ1-1. ..
  23. Reactivation of GSTP1 Gene by Green Tea Polyphenols
    Sanjay Gupta; Fiscal Year: 2005
    ..One such alteration is silencing of the expression of glutathione S-transferase-pi (GSTP1), a critical enzyme of carcinogen defense, through methylation of deoxycytidine residue in CpG islands in the 5'- ..
  24. ENZYME INDUCTION DEFECT--IMPLICATION FOR TOXICITY
    Robert Blouin; Fiscal Year: 1992
    ..FActors which influence the activation of foreign compounds, bear directly on risk of xenobiotic exposure to human health...
  25. GENE EXPRESSION INDICES ASSOCIATED WITH CHEMORESISTANCE
    James Willey; Fiscal Year: 2001
    ....
  26. LEUKOTRIENES--BIOCHEMICAL PHARMACOLOGY
    SISTER JAKSCHIK; Fiscal Year: 1990
    ..We hope to definitely demonstrate the difference of the LTC4-synthesizing enzyme from other glutathione transferases which would make it possible to design selective inhibitors of LTC4 biosynthesis...
  27. LUNG INJURY BY NAPHTHALENES
    Alan Buckpitt; Fiscal Year: 2009
    ..These studies are expected to identify appropriate biomarker targets and metabolic proteins where polymorphisms could be important in altering individual susceptibility. ..
  28. COLLABORATIVE PROJECT FOR AN ENZYME FUNCTION INITIATIVE
    JOHN GERLT; Fiscal Year: 2009
    ....
  29. Oxidant Stress and Allergic Asthma
    Ryszard Dworski; Fiscal Year: 2009
    ..Polymorphisms of the glutathione S transferase (GSTP1) gene predict airway hyperreactivity, asthma, and atopy...
  30. MECHANISM OF ANTICARCINOGENIC ACTIVITY--ORGANOSULFIDES
    Shivendra Singh; Fiscal Year: 2003
    ..Insights gained from these studies should help in devising practical dietary recommendation for humans. ..
  31. DNA Methylation and GSTP1 Gene Regulation in Gliomas
    Francis Ali Osman; Fiscal Year: 2007
    ..molecular alteration in brain and other human tumors is the over-expression of the glutathione S-transferase P1 (GSTP1) gene...
  32. Allergies, Genetic Susceptibility and Adult Glioma Risk
    Dominique S Michaud; Fiscal Year: 2011
    ..Studies have also reported associations with detoxification genes, especially GSTT1 and GSTP1. However, most epidemiologic studies reporting these associations have been case- control studies, which are ..
  33. Pharmacogenetics of Tamoxifen and Chemotherapies and Risk of Contralateral Breast
    Jane C Figueiredo; Fiscal Year: 2010
    ..e., CYP3A5, GSTM1, GSTP1, GSTT1);anthracyclines (i.e., CYP3A5, MDR1, GSTM1, GSTP1, GSTT1) and antimetabolites (i.e., DHFR, TS, MTHFR) ...
  34. Halogenated Alkenes and Microsomal GSH-transferases
    Michael J Kelner; Fiscal Year: 2010
    ..4] To determine the relative contribution of MGST1 and MGST2 to cellular antioxidant capacity through studies utilizing human MGST1 and MGST2 null cells. ..
  35. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..DNA samples from mother and infant will be used to type genetic polymorphisms (CYP1A1, GSTM1, GSTT1, GSTP1, Xrcc1, XPD) relevant to the hypothesized mechanisms...
  36. Genetic Susceptibilty to Cardiovascular Effects of Arsenic Exposure
    Yu Chen; Fiscal Year: 2013
    ..effects of As exposure differ by polymorphisms in genes related to As methylation (GSTM1, GSTT1, GSTO1, GSTP1, MTHFR, and AS3MT genes) and genes related to oxidative stress (NOS3, SOD2, and CYBA) and inflammation/endothelial ..
  37. GST, ENVIRONMENT FACTORS AND BREAST CANCER RISK
    Tongzhang Zheng; Fiscal Year: 2000
    ..study is to examine the association between genetic variability in three major GSTs, namely, GSTM1, GSTT1, and GSTP1 and the susceptibility to breast cancer...
  38. Molecular Analysis of Esophageal Cancer Survival
    Matthew Kulke; Fiscal Year: 2007
    ..aims of examining the association between overall survival and the presence of specific genetic polymorphisms (GSTP1, GSTM1, GSTT1, CYP1A1, CYP3A5, p53, XRCC1 and ERCC2) in patients with esophageal cancer...
  39. Shuji Kishi; Fiscal Year: 2014
    ..expression of most antioxidant enzymes including the Pi class glutathione S-transferases (GSTP1s);indeed, gstp1 is strongly induced upon Nrf2 activation in vertebrates when the animals are treated with electrophiles...
  40. Pesticide Exposure and DNA Methylation in Pesticide Applicators
    JENNIFER ANN RUSIECKI; Fiscal Year: 2010
    ..for four of the most commonly silenced genes in cancers of concern to this cohort, p16INK4, MGMT, CDH-1, and GSTp1. Our primary aim is to investigate whether exposure to specific pesticides and chemical classes of pesticides ..
  41. GSTP1 gene repression in prostate cancer
    Rakesh Singal; Fiscal Year: 2004
    ..Among the isoenzymes, the role of the pi class GSTP (GSTP1) in cancer has been studied extensively...
  42. Pharmacokinetic and Pharmacogenomic Determinants of Cisplatin Kidney Injury
    Melanie S Joy; Fiscal Year: 2013
    ..g. GSTP1 and GSTA1, and g-glutamyl transferase1, e.g...
  43. A novel mouse prostate carcinogenesis model for dietary cancer prevention researc
    Chung S Yang; Fiscal Year: 2013
    ..and TUNEL), inflammation (NF-kB and CD45), and oxidative stress (8-OHdG and -H2AX), as well as the expression of GSTP1, E-cadherin, COX-2, p63, p27, Pten, Nkx3.1, p16, and Bcl-2 by immunohistochemistry (IHC)...
  44. Spatial, High-Accuracy, Multiplexed Mapping of Genes in Human Tissue Sections
    Elisabeth Smela; Fiscal Year: 2012
    ..6 millimeter per spot). Our aims now are to Aim 1 (achieve DNA methylation): Map GSTP1 promoter methylation over whole tissue sections from prostates with cancer...
  45. Promoter Specific Hypermethylation Sensors for Early Cancer Detection
    Indraneel Ghosh; Fiscal Year: 2011
    ..2) designing and testing biosensors that target promoter regions of genes (BRCA1, CDH1, p15, p16, MGMT, GSTp1) implicated in cancer...
  46. Screen for Small Molecule Antagonists of MBD2
    WILLIAM GEORGE NELSON; Fiscal Year: 2013
    ..Using novel cell-based screens to detect small molecules capable of selective activation of a GSTP1 promoter/luciferase reporter construct carrying extensive CpG island methylation, a configuration known to cause ..
  47. Oxidant Stress and Gene Polymorphisms in Bronchopulmonary Dysplasia
    Karen K Mestan; Fiscal Year: 2013
    ..of oxidant stress and the development of BPD;and 2) To assess genetic associations of promising candidate genes (GSTP1, SOD3) with the risk of BPD, with adjustment for important clinical variables, population admixture, and multiple ..
  48. SPORE in Brain Cancer
    Darell Bigner; Fiscal Year: 2009
    ..In Project 1, novel therapeutics that target the GSTP1 protein, overexpressed and a poor prognostic indicator in malignant gliomas, will be rationally developed and ..
  49. Isothiocyanates in the Chemoprevention of Bladder Cancer
    Yuesheng Zhang; Fiscal Year: 2007
    ..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
  50. Pharmacogenetics: Breast Cancer Treatment and Prognosis
    Christine Ambrosone; Fiscal Year: 2005
    ..These hypotheses are supported by our pilot data, in which women with GSTP1 and GSTA1 variants encoding lower enzyme activity and those with gene deletions in GSTM1 and GSTT1 had ..
  51. Metabolism and Detoxification of Base Propenals
    Sanjay Srivastava; Fiscal Year: 2007
    ..Based on our preliminary data and literature evidence, we propose that glutathione S-transferase (GSTP1-1) and aldose reductase (AR) are the major enzymes that participate in the metabolism of base propenals and that ..
  52. Metabolic Polymorphisms and Survival from Brain Tumors
    Melissa Bondy; Fiscal Year: 2004
    ..We will determine the frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in 350 cases by polymerase chain reaction and restriction fragment length polymorphisms...
  53. CASA PIA STUDY OF DENTAL AMALGAMS IN CHILDREN
    Timothy Derouen; Fiscal Year: 2005
    ..abstract_text> ..
  54. INSECT SPECIES FOR ASSESSMENT OF PROXIDANT TOXICITY
    SAMI AHMAD; Fiscal Year: 1992
    ..oxidized glutathione). In turn, this will enable us to determine whether results obtained using a nonmammalian model species are applicable to studies of the oxidative stress in mammalian systems...
  55. Age-related epigenetic gene silencing in the RPE
    LEONARD HJELMELAND; Fiscal Year: 2007
    ..To test this hypothesis, we will focus our initial studies on TIMP3, BRCA1, IGF2, and GSTP1. We have shown that the expression at the mRNA level of all four genes is downregulated with age in the RPE/..
  56. Adenocarinoma of the Lung in Women
    Ann Schwartz; Fiscal Year: 2005
    ..2) To determine if genotype at the metabolic enzyme loci CYP1A1, CYP1B1, CYP17, CYP19, GSTM1, GSTP1, COMT, and NQO1 are associated with risk of adenocarcinoma of the lung in women...
  57. GENE EXPRESSION INDICES IN CHEMORESISTANT LUNG CANCER
    James Willey; Fiscal Year: 2003
    ..individual gene expression values when phenotypes for malignancy (c-myc x E2F-1/p21) and risk for lung cancer (GSTP1 x mGST x GSHPx)...
  58. DNA Methylation in Early Detection of Prostate Cancer
    Steven Smith; Fiscal Year: 2002
    ..Our hypothesis is that methylation status at the androgen receptor gene, pi-class glutathione-S transferase gene GSTP1, L1 repetitive, or subtelomeric DNA sequences, or subtelomeric DNA sequences coupled with telomerase component ..
  59. Chronic respiratory effects of early life PM exposure
    Kirk Smith; Fiscal Year: 2009
    ..Variation in the genotypes of key antioxidant enzymes (e.g., GSTM1 and GSTP1) may help to identify which children are more susceptible to the effects of inhaled PM on respiratory health...
  60. Molecular Detection of Prostate Cancer in Urine
    Paul Cairns; Fiscal Year: 2005
    ..Using the sensitive methylation specific PCR we have established that a new molecular target, GSTP1 gene hypermethylation which is well established as "early", frequent and cancer specific can be detected in a ..
  61. LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS
    Jenny Mao; Fiscal Year: 2007
    ..in bronchoalveolar lavage fluid, expression of Cox-2, EGFR, p27,p16, bcl-2, apoptosis index, cyclin D1 and E, GSTP1 methylation, GSTP1, GSTM1 and CYP1A1 polymorphisms, P53 polymorphisms and p16 methylation; 2) regulation of ..
  62. Drug Metabolism, DNA Repair & Second Cancers
    Debra Friedman; Fiscal Year: 2003
    ..study include methylenetetrahydrofolate reductase (MTHFR), Glutathione-S-transferase (GST), GSTT1, GSTM1, GSTM3, GSTP1, Cytochrome P-450 (CYP) CYP2C9, CYP2C19, CYP3A4, thiopurine methyltransferase, methylguanine DNA methyltransferase,..
  63. INFERTILITY TESTING OF RECOMBINANT SP-10 VACCINE
    John Herr; Fiscal Year: 1993
    ..The research aims outlined in this proposal follow the direct path to development of a contraceptive vaccine with potential use in human females...