GSTM1

Summary

Gene Symbol: GSTM1
Description: glutathione S-transferase mu 1
Alias: GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, MU-1, glutathione S-transferase Mu 1, GST HB subunit 4, GST class-mu 1, HB subunit 4, S-(hydroxyalkyl)glutathione lyase, glutathione S-alkyltransferase, glutathione S-aralkyltransferase, glutathione S-aryltransferase, glutathione S-transferase M1
Species: human

Top Publications

  1. pmc Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study
    Nicole A Lavender
    Department of Pharmacology and Toxicology, University of Louisville UofL, School of Medicine, 500 South Preston Street, Room 1319 Research Tower, UofL Health Science Center, Louisville, KY 40202, USA
    BMC Cancer 9:397. 2009
  2. pmc Polymorphisms of glutathione-S-transferase M1, T1, P1 and the risk of prostate cancer: a case-control study
    Monika Sivoňová
    Department of Medical Biochemistry, Comenius University, Jessenius School of Medicine, Martin, Slovakia
    J Exp Clin Cancer Res 28:32. 2009
  3. doi Association of glutathione S-transferases polymorphisms (GSTM1 and GSTT1) with senile cataract: a meta-analysis
    Lei Sun
    Department of Ophthalmology, Fourth Hospital of Harbin Medical University, Harbin, People s Republic of China
    Invest Ophthalmol Vis Sci 51:6381-6. 2010
  4. pmc NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Lancet 366:649-59. 2005
  5. ncbi Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 12:1429-37. 2003
  6. ncbi Polymorphism of GSTM1 and GSTT1 genes in prostate cancer: a study from North India
    R D Mittal
    Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Cancer 41:115-9. 2004
  7. ncbi Polymorphisms at GSTM1 and GSTP1 gene loci and risk of prostate cancer in a South Indian population
    K Vijayalakshmi
    Department of Human Genetics, Sri Ramachandra Medical College and Research Institute Deemed University, Chennai 600116, Tamil Nadu, India
    Asian Pac J Cancer Prev 6:309-14. 2005
  8. pmc Maternal smoking, GSTM1 and GSTT1 polymorphism and susceptibility to adverse pregnancy outcomes
    Regina Grazuleviciene
    Vytautas Magnus University, K Donelaicio g 58, LT 44248, Kaunas, Lithuania
    Int J Environ Res Public Health 6:1282-97. 2009
  9. doi Polymorphisms of glutathione-S-transferase M1 and T1 and prostate cancer risk in a Tunisian population
    Yousra Souiden
    Laboratory of Molecular Biology, Hospital of Ibn Eljazzar of Kairouan, avenue Ibn ElJazzar, Kairouan 3140, Tunisia
    Cancer Epidemiol 34:598-603. 2010
  10. doi Association of GSTM1T1 genes with COPD and prostate cancer in north Indian population
    Hitender Thakur
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Biol Rep 38:1733-9. 2011

Research Grants

  1. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
  2. Ozone Cardiovascular Effects in Genetically Susceptible People
    MARK WALTER FRAMPTON; Fiscal Year: 2012
  3. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
  4. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2009
  5. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
  6. Thu H Le; Fiscal Year: 2015
  7. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
  8. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010
  9. Mohammad H Rahbar; Fiscal Year: 2016
  10. Beverly H Koller; Fiscal Year: 2014

Detail Information

Publications357 found, 100 shown here

  1. pmc Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study
    Nicole A Lavender
    Department of Pharmacology and Toxicology, University of Louisville UofL, School of Medicine, 500 South Preston Street, Room 1319 Research Tower, UofL Health Science Center, Louisville, KY 40202, USA
    BMC Cancer 9:397. 2009
    ..Thus, we evaluated the effects of polymorphic GSTs (M1, T1, and P1) alone and combined with cigarette smoking on PCA susceptibility...
  2. pmc Polymorphisms of glutathione-S-transferase M1, T1, P1 and the risk of prostate cancer: a case-control study
    Monika Sivoňová
    Department of Medical Biochemistry, Comenius University, Jessenius School of Medicine, Martin, Slovakia
    J Exp Clin Cancer Res 28:32. 2009
    ..A further aim of the study was to evaluate polymorphisms in GST also in patients with prostate cancer in order to compare the evaluated proportions with those found in the control subjects...
  3. doi Association of glutathione S-transferases polymorphisms (GSTM1 and GSTT1) with senile cataract: a meta-analysis
    Lei Sun
    Department of Ophthalmology, Fourth Hospital of Harbin Medical University, Harbin, People s Republic of China
    Invest Ophthalmol Vis Sci 51:6381-6. 2010
    ..However, the results are not consistent. In this study, the authors conducted a meta-analysis to assess the association between GSTM1 and GSTT1 null genotypes and the risk for senile cataract.
  4. pmc NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Lancet 366:649-59. 2005
    ..An exception could be the association between NAT2 slow acetylation, GSTM1 null genotype, and bladder-cancer risk...
  5. ncbi Comprehensive assessment of candidate genes and serological markers for the detection of prostate cancer
    Robert K Nam
    Division of Urology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada
    Cancer Epidemiol Biomarkers Prev 12:1429-37. 2003
    ..The GST-T1 and IGF-I polymorphisms demonstrated modest associations with prostate cancer risk. IGF-I levels were not helpful in identifying patients with prostate cancer at the time of biopsy...
  6. ncbi Polymorphism of GSTM1 and GSTT1 genes in prostate cancer: a study from North India
    R D Mittal
    Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian J Cancer 41:115-9. 2004
    ..The genetic polymorphisms of GSTM1 and GSTT1 genes have been studied earlier to evaluate the relative risk of various cancers...
  7. ncbi Polymorphisms at GSTM1 and GSTP1 gene loci and risk of prostate cancer in a South Indian population
    K Vijayalakshmi
    Department of Human Genetics, Sri Ramachandra Medical College and Research Institute Deemed University, Chennai 600116, Tamil Nadu, India
    Asian Pac J Cancer Prev 6:309-14. 2005
    ..We here assessed the association of GSTM1 and GSTP1 polymorphisms with susceptibility to prostate cancer in a case-control study of 75 patients and 100 age-..
  8. pmc Maternal smoking, GSTM1 and GSTT1 polymorphism and susceptibility to adverse pregnancy outcomes
    Regina Grazuleviciene
    Vytautas Magnus University, K Donelaicio g 58, LT 44248, Kaunas, Lithuania
    Int J Environ Res Public Health 6:1282-97. 2009
    The objective of the study was to investigate the association between maternal smoking, GSTM1, GSTT1 polymorphism, low birth weight (LBW, < 2,500 g) and intra-uterine growth restriction (IUGR, < 2,500 g and gestation > or = 37 ..
  9. doi Polymorphisms of glutathione-S-transferase M1 and T1 and prostate cancer risk in a Tunisian population
    Yousra Souiden
    Laboratory of Molecular Biology, Hospital of Ibn Eljazzar of Kairouan, avenue Ibn ElJazzar, Kairouan 3140, Tunisia
    Cancer Epidemiol 34:598-603. 2010
    ..This study is focused on the polymorphic enzymes glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) that involved in the detoxification of many xenobiotics involved in the etiology of prostate cancer...
  10. doi Association of GSTM1T1 genes with COPD and prostate cancer in north Indian population
    Hitender Thakur
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Biol Rep 38:1733-9. 2011
    ..The objective of the present study was to investigate the role of GSTM1 and GSTT1 null genotypes as risk factors for chronic obstructive pulmonary disease (COPD) and prostate cancer...
  11. doi Evaluation of the influence of polymorphic variants CYP1A1 2B, CYP1B1 2, CYP3A4 1B, GSTM1 0, and GSTT1 0 in prostate cancer
    Iara S Rodrigues
    Departamento de Biologia Geral, CCB, Londrina, Brazil
    Urol Oncol 29:654-63. 2011
    ..In the present study, 5 polymorphic variants were examined in 154 patients with prostate carcinoma and in 154 controls...
  12. doi Are GSTM1, GSTT1 and CAG repeat length of androgen receptor gene polymorphisms associated with risk of prostate cancer in Iranian patients?
    Zahra Ousati Ashtiani
    Department of Medical Genetics, School of Medicine, Tehran University of Medical Science, Tehran, Iran
    Pathol Oncol Res 17:269-75. 2011
    We conducted this study to investigate whether CAG repeat length in androgen receptor gene and GSTM1 and GSTT1 polymorphisms influence prostate cancer risk in Iranian newly diagnosed cancer patients compared to age-matched BPH group and ..
  13. doi Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran, Iran
    M R Safarinejad
    Prostate Cancer Prostatic Dis 14:105-13. 2011
    We evaluated the relationship between polymorphisms in the glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 genes and prostate cancer (PCa)...
  14. doi Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses
    Wen lei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, 400038 Chongqing, China
    J Cancer Res Clin Oncol 135:1081-90. 2009
    Previous evidence implicates CYP1A1 and GSTM1 polymorphisms as risk factors for various cancers...
  15. doi Null genotypes of GSTM1 and GSTT1 contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis
    Bin Wang
    The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
    J Hepatol 53:508-18. 2010
    ..Thus, a meta-analysis was performed to clarify the effects of GSTM1 and GSTT1 polymorphisms on HCC risk.
  16. ncbi Influence of glutathione S-transferase M1 and T1 genotypes on larynx cancer risk among Korean smokers
    Y J Hong
    Department of Clinical Pathology, Korea Cancer Center Hospital, Seoul
    Clin Chem Lab Med 38:917-9. 2000
    ..It is thus conceivable that deficiency in GST activity due to homozygous deletions of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers...
  17. ncbi Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
    ..between susceptibility to ATL and several polymorphisms: the three "decreased-detoxifying" polymorphisms in GSTM1, GSTT1, and CYP1A1, the "proapoptotic" polymorphism in BCL2, and the five "high-production" polymorphisms in tumor ..
  18. ncbi Relationship of tobacco smoking with GSTM1 gene polymorphism in laringeal cancer
    F Bardakci
    Department of Biology, Faculty of Science, Cumhuriyet University Hospital, Sivas, Turkey
    J Cell Mol Med 7:307-12. 2003
    This paper aimed to analyze the association of polymorphism of GSTM1 0/0 genotype with laryngeal cancer along a hospital based case-control study...
  19. ncbi Glutathione S-transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers
    Nilabja Sikdar
    Anthropology and Human Genetics Unit, Biological Sciences Division, Indian Statistical Institute, Kolkata, India
    Int J Cancer 109:95-101. 2004
    ..study consisting of 109 leukoplakia and 256 oral cancer patients and 259 controls, genotype frequencies at GSTM1, GSTT1, GSTM3 and GSTP1 loci were determined by polymerase chain reaction-restriction fragment length polymorphism ..
  20. ncbi Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway
    Halla Skuladottir
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Lung Cancer 48:187-99. 2005
    ..relevant demographic and lifestyle characteristics, and polymorphisms in following genotypes were determined GSTM1, GSTM3, GSTP1, GSTT1, GPX1, MPO, NQO1 and NAT2...
  21. ncbi Polymorphisms of CYP1A1, GSTM1, GSTT1, and prostate cancer risk in Turkish population
    Yavuz Silig
    Cumhuriyet University, Science and Art Faculty, Department of Biochemistry, Sivas, Turkey
    Cancer Invest 24:41-5. 2006
    ..study, association of the prostate cancer risk with genotype frequencies of the Phase I (CYP1A1) and Phase II (GSTM1 and GSTT1) biotransformation enzymes was investigated in 321 Turkish individuals (152 prostate cancer patients and ..
  22. ncbi Genetic polymorphism at GSTM1 and GSTT1 gene loci and susceptibility to oral cancer
    A Sharma
    Division of Molecular Genetics, Institute of Cytology and Preventive Oncology, ICMR, I 7, Noida 201301, Uttar Pradesh, India
    Neoplasma 53:309-15. 2006
    ..This study evaluates the influence of genetic polymorphisms of GSTM1 and GSTT1 gene loci on susceptibility to oral cancer...
  23. ncbi Evaluating polymorphic status of glutathione-S-transferase genes in blood and tissue samples of prostate cancer patients
    Rama Devi Mittal
    Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    Asian Pac J Cancer Prev 7:444-6. 2006
    ..The glutathione S-transferase (GST) enzymes detoxify several carcinogens and genetic polymorphisms in GSTM1, T1, and P1 (Ile105Val) have been reported to be associated with prostate cancer, mainly from blood samples...
  24. ncbi Comprehensive analysis of excision repair complementation group 1, glutathione S-transferase, thymidylate synthase and uridine diphosphate glucuronosyl transferase 1A1 polymorphisms predictive for treatment outcome in patients with advanced gastric cancer
    Bong Gun Seo
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Korea
    Oncol Rep 22:127-36. 2009
    ..1 months (95% CI, 0.1-6.1 months) and 13.9 months (95% CI, 12.2-15.6 months), respectively. Only the GSTM1 positive genotype exhibited a significantly better time to progression (P=0.023)...
  25. ncbi Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe
    P Soucek
    National Institute of Public Health, Prague, Czech Republic
    Neoplasma 57:415-21. 2010
    ..functional polymorphisms in enzymes metabolizing smoke constituents and/or alcohol (CYP2A13, CYP1B1, EPHX1, NQO1, GSTM1, GSTP1, GSTT1, ADH1B and ADH1C)...
  26. pmc Association of GSTM1 and GSTT1 polymorphism with lipid peroxidation in benign prostate hyperplasia and prostate cancer: a pilot study
    Vivek Kumar
    Department of Biochemistry, University College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad Garden, Delhi, India
    Dis Markers 30:163-9. 2011
    ..Based on genotyping, subjects were categorized into: GSTM1+/GSTT1+, GSTM1-/GSTT1+, GSTM1+/GSTT1- and GSTM1-/GSTT1-...
  27. doi GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis
    Konstantinos P Economopoulos
    School of Medicine, National University of Athens, Greece
    Eur J Cancer 46:1617-31. 2010
    ..Controversy exists about whether GST polymorphisms (GSTM1 null/present genotype, GSTT1 null/present genotype, GSTP1 Ile105Val and GSTA1 *A/*B) represent risk factors for ..
  28. doi Glutathione S-transferase M1, GSTT1 and GSTP1 genetic polymorphisms and the risk of age-related macular degeneration
    Mehmet Guven
    Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Ophthalmic Res 46:31-7. 2011
    ..To determine the possible effects of glutathione S-transferase (GST) M1, GSTT1 and GSTP1 genetic polymorphisms on the risk of developing age-related macular degeneration (AMD)...
  29. pmc GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma
    Ahmed Abbas
    GRECAN EA1772, UFR des Sciences Pharmaceutiques, Universite de Caen Basse Normandie et Centre Francois Baclesse, Avenue du General Harris, 14076 Caen Cedex 05, France
    World J Gastroenterol 10:3389-93. 2004
    ..To evaluate the association between CYP1A1 and GSTs genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma (SCC) and esophageal adenocarcinoma (ADC) in a high risk area of northwest of France...
  30. ncbi Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk
    Jordi To-Figueras
    Toxicology Unit, ORL Unit, Hospital Clinic, IDIBAPS, Ciutat Sanitaria de Bellvitge, Departament de Salut Publica, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Cancer Lett 187:95-101. 2002
    ..epoxide hydrolase gene (EPHX1, 113Tyr-->113His, 139His-->139Arg) and four glutathione S-transferase genes (GSTM1, GSTM3, GSTP1, GSTT1) were genotyped in a group of patients with larynx cancer (N=204) and in a group of healthy ..
  31. ncbi Glutathione S-transferase M1 gene but not insulin-like growth factor-2 gene or epidermal growth factor gene is associated with prostate cancer
    Ming Tsung Lai
    Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
    Urol Oncol 23:225-9. 2005
    ..This study suggests that the GST M1 gene, but not the IGF-2 or the EGFR genes, may be a risk factor of developing prostate cancer in Taiwan...
  32. doi Association of common copy number variants at the glutathione S-transferase genes and rare novel genomic changes with schizophrenia
    B Rodriguez-Santiago
    Unitat de Genètica, Universitat Pompeu Fabra, and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, Barcelona, Spain
    Mol Psychiatry 15:1023-33. 2010
    ..and controls, the combined analysis of gene copy number genotypes at two glutathione S-transferase (GST) genes, GSTM1 (glutathione S-transferase mu 1) (1p13.3) and GSTT2 (glutathione S-transferase theta 2) (22q11...
  33. doi Mitochondrial damage in the trabecular meshwork of patients with glaucoma
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Arch Ophthalmol 128:724-30. 2010
    ..Oxidative damage plays a major role in glaucoma pathogenesis. Since no environmental risk factor for glaucoma is recognized, we focused our attention on mitochondria, the main endogenous source of reactive oxygen species...
  34. doi CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations
    Kyoung Mu Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    Cancer Epidemiol Biomarkers Prev 17:1120-6. 2008
    To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic ..
  35. pmc Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties
    B Mannervik
    Proc Natl Acad Sci U S A 82:7202-6. 1985
    ..It is suggested that the similarities of the isoenzymes in a class reflect evolutionary relationships and that the classification applies generally...
  36. ncbi Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer
    Mia Hashibe
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 12:1509-17. 2003
    Sequence variation in the GSTM1, GSTT1, GSTP1, and CYP1A1 genes may potentially alter susceptibility to head and neck cancers, although evidence from previous studies has not been consistent...
  37. ncbi Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype
    Christine B Ambrosone
    Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Nutr 134:1134-8. 2004
    ..of cruciferous vegetables, sources of ITCs, and breast cancer risk, and potential modification of relations by GSTM1 and GSTT1 genotypes...
  38. ncbi CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma
    Marzena Gajecka
    Institute of Human Genetics, Polish Academy of Sciences, 32 Strzeszynska, 60 479 Poznan, Poland
    Mutat Res 574:112-23. 2005
    Polymorphisms in the selected genes controlling carcinogen metabolism (CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1, GSTT1) considered separately or in different combinations, were investigated for an association with tobacco smoke-associated ..
  39. pmc Phase I and II enzyme polymorphisms as risk factors for Barrett's esophagus and esophageal adenocarcinoma: a systematic review and meta-analysis
    L M Bull
    Baylor College of Medicine, Houston, Texas, USA
    Dis Esophagus 22:571-87. 2009
    ..50, 95% confidence interval [CI] 1.16-1.95; OR(EAC)= 1.20, 95% CI 0.94-1.54). No excess risk was observed with GSTM1 null (OR(BE)= 0.77, 95% CI: 0.56-1.08; OR(EAC)= 1.08, 95% CI: 0.79-1.48), GSTT1 null (OR(BE)= 1.35, 95% CI: 0.91-2...
  40. pmc The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer
    Dongping Li
    International Centre for Genetic Engineering and Biotechnology ICGEB, UCT Campus, Anzio Road Observatory 7925, Cape Town, South Africa
    BMC Genet 11:47. 2010
    ..Genetic polymorphisms in GSTs were investigated in 245 patients and 288 controls samples by PCR-RFLP analysis...
  41. ncbi Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore
    B Zhao
    Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore 117597
    Cancer Epidemiol Biomarkers Prev 10:1063-7. 2001
    ..We evaluated the association between dietary isothiocyanate intake, GSTM1 and GSTT1 polymorphisms, and lung cancer risk in 420 Chinese women: 233 histologically confirmed lung cancer ..
  42. ncbi Genetic polymorphisms of cytochrome p450 2E1, glutathione S-transferase M1 and T1, and susceptibility to gastric carcinoma in Taiwan
    Ming Shiang Wu
    Department of Internal Medicine, National Taiwan University Hospital, No 7 Chung Shan S Rd, Taipei, Taiwan
    Int J Colorectal Dis 17:338-43. 2002
    ..and detoxification of N-nitrosamines and related compound, studies on the relationship between genetic polymorphisms of CYP2E1, GSTT1, and GSTM1 and the risk of gastric carcinoma (GC) are few, and the results have been conflicting.
  43. ncbi Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer
    Shioto Suzuki
    Department of Molecular and Cellular Pathology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Gastroenterol 39:220-30. 2004
    ..Therefore, we studied the relationship between the genetic polymorphisms of drug-metabolizing enzymes, drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer...
  44. ncbi Polymorphisms of GSTP1 and related genes and prostate cancer risk
    T M Beer
    Division of Hematology and Medical Oncology, Oregon Health Sciences University, Oregon, USA
    Prostate Cancer Prostatic Dis 5:22-7. 2002
    ..Genotyping of the GSTP1 (Ile105Val), GSTM1 (null), GSTT1 (null) and CYP1A1 (Ile462Val) genes was performed using polymerase chain reaction (PCR) based ..
  45. ncbi [Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China]
    Ge Yu Liang
    School of Public Health, Southeast University, Nanjing 210009, China
    Yi Chuan 26:584-8. 2004
    ..The polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1, mEH and NQO1 genes were analyzed by PCRjRFLP assay...
  46. ncbi [Association of genetic polymorphisms in glutathione S-transferases M1 with hepatitis beta-related hepatocellular carcinoma]
    Man hua Zhu
    Institute of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 34:126-30. 2005
    ..To investigate the association of genetic polymorphisms in glutathione S-transferases(GST) M1 with hepatitis beta-related hepatocellular carcinoma (HCC)...
  47. ncbi Polymorphisms in glutathione-related genes affect methylmercury retention
    Hipolito M Custodio
    Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
    Arch Environ Health 59:588-95. 2004
    ..mercury concentration (EryHg), plasma polyunsaturated fatty acids (PPUFA), and genotype for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 365 individuals...
  48. ncbi Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator
    Devasena Anantharaman
    Cancer Research Institute, Advanced Center for Treatment, Research and Education in Cancer, Tata Memorial Center, Kharghar, Navi Mumbai 410 208, India
    Carcinogenesis 28:1455-62. 2007
    ..This study investigates the role of polymorphisms at CYP1A1, GSTM1 and GSTT1 to oral squamous cell carcinoma (OSCC) in a case-control study involving 155 patients with precancerous ..
  49. doi A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction
    Ali Delpisheh
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, UK
    Eur J Obstet Gynecol Reprod Biol 143:38-42. 2009
    To determine the role of maternal CYP1A1, GSTT1, and GSTM1 metabolic gene polymorphisms in modulating the association between pregnancy smoking exposure and fetal growth restriction.
  50. doi Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses
    Wen lei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Arch Med Res 40:169-79. 2009
    Previous studies have implicated cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) polymorphisms as risk factors for various cancers...
  51. doi Dietary glucosinolate intake, polymorphisms in selected biotransformation enzymes, and risk of prostate cancer
    Astrid Steinbrecher
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 19:135-43. 2010
    ..possible association between glucosinolate intake and prostate cancer risk is modified by polymorphisms in GSTT1, GSTM1, GSTA1, GSTP1, or NOQ1 genes...
  52. doi Genetic polymorphisms of glutathione S-transferase M1 and bladder cancer risk: a meta-analysis of 26 studies
    Ronggui Zhang
    Department of Urology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China
    Mol Biol Rep 38:2491-7. 2011
    Studies investigating the association between glutathione S-transferase M1 (GSTM1) polymorphism and bladder cancer risk report conflicting results...
  53. pmc Is the GSTM1 null polymorphism a risk factor in primary open angle glaucoma?
    Auta Viviane Rocha
    Universidade Estadual de Santa Cruz, Departamento de Ciências da Saúde, Laboratório de Farmacogenômica e Epidemiologia Molecular, Ilheus, Bahia, Brazil
    Mol Vis 17:1679-86. 2011
    To investigate the association of glutathione S-transferase (GST) GSTM1, GSTT1, and GSTP1 genes with the risk of primary open angle glaucoma (POAG) and clinical features of the disease.
  54. pmc GST polymorphisms are associated with hepatocellular carcinoma risk in Chinese population
    Lei Yu
    Department of Infectious Disease, the Fourth Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
    World J Gastroenterol 17:3248-56. 2011
    To investigate the association between GSTM1 and GSTT1 polymorphisms and the risk of hepatocellular carcinoma (HCC) in Chinese population.
  55. ncbi Polymorphisms at GSTM1 and GSTT1 gene loci and susceptibility to cervical cancer in Indian population
    A Sharma
    Division of Molecular Genetics, Institute of Cytology and Preventive Oncology, Bahadur Shah Zafar Marg, New Delhi, India
    Neoplasma 51:12-6. 2004
    ..A multiplex polymerase chain reaction method was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA isolated from cases with cervical cancer (n=142) and normal controls (n=96)...
  56. ncbi Genetic polymorphisms of GSTM1, p21, p53 and HPV infection with cervical cancer in Korean women
    Sang Ah Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Gynecol Oncol 93:14-8. 2004
    The aim of this study was to determine whether GSTM1 or GSTT1 might be associated with risk of cervical cancer development in Korean women...
  57. ncbi Glutathione-S-transferase and p53 polymorphisms in cervical carcinogenesis
    Masatsugu Ueda
    Department of Obstetrics and Gynecology, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka 569 8686, Japan
    Gynecol Oncol 96:736-40. 2005
    To investigate the clinical significance of glutathione-S-transferase GSTM1, GSTT1 and p53 codon 72 polymorphisms in cervical carcinogenesis.
  58. ncbi Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection
    Thomas Joseph
    Department of Molecular Medicine, Regional Cancer Centre, Trivandrum, India
    Gynecol Oncol 101:411-7. 2006
    ..This study looked into possible relationships among these factors...
  59. ncbi Interaction of passive smoking with GST (GSTM1, GSTT1, and GSTP1) genotypes in the risk of cervical cancer in India
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Cancer Genet Cytogenet 166:117-23. 2006
    ..Thus, it is quite possible that polymorphism at detoxifying enzyme coding loci such as GSTM1, GSTT1, and GSTP1 may determine susceptibility to cervix cancer...
  60. ncbi Glutathione-S-transferase M1 and T1 genetic polymorphisms and the risk of cataract development: a study in the Turkish population
    Mehmet Guven
    Department of Medical Biology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Curr Eye Res 32:447-54. 2007
    In this study, we aimed to determine the effects of genetic polymorphisms of glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) on risk of developing different subtypes of age-related cataract in the Turkish ..
  61. ncbi Glutathione-S-transferase polymorphism, metallothionein expression, and mercury levels among students in Austria
    Claudia Gundacker
    Medical University of Vienna, Center for Public Health, Dept of Ecotoxicology, Waehringer Strasse 10, A 1090 Vienna, Austria
    Sci Total Environ 385:37-47. 2007
    ..Humans accumulate heavy metals primarily as a result of lifestyle and environmental contamination. However, not all humans experience the estimated individual exposure. This suggests the presence of genetic regulatory mechanisms...
  62. ncbi Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia
    Carlos H Sierra-Torres
    Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555, USA
    Environ Mol Mutagen 41:69-76. 2003
    ..that environmental exposure to cigarette smoke and inheritance of polymorphic chemical metabolizing genes (CYP2E1, GSTM1, and mEH) significantly increase the risk for neoplasia...
  63. pmc Glutathione S-transferase M1 and T1 polymorphisms in Arab glaucoma patients
    Khaled K Abu-Amero
    Genetics Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Mol Vis 14:425-30. 2008
    ..In humans, GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) are associated with a variety of pathologic processes including certain ..
  64. doi Cigarette smoking and glutathione S-transferase M1 polymorphism associated with risk for uterine cervical cancer
    Koji Nishino
    Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Obstet Gynaecol Res 34:994-1001. 2008
    ..To elucidate the role of tobacco smoking and polymorphisms of carcinogen metabolism genes in cervical carcinogenesis...
  65. doi Glutathione S-transferase M1 polymorphism and sporadic colorectal cancer risk: An updating meta-analysis and HuGE review of 36 case-control studies
    Yong Gao
    Department of Urology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People s Republic of China
    Ann Epidemiol 20:108-21. 2010
    ..The glutathione S-transferase M1 gene (GSTM1) is a particularly attractive candidate for CRC susceptibility because it codes an enzyme involved in the ..
  66. ncbi Analysis of the Glutathione S-transferase M1 gene using pyrosequencing and multiplex PCR--no evidence of association to glaucoma
    Mattias Jansson
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala SE 751 85, Sweden
    Exp Eye Res 77:239-43. 2003
    The Glutathione S-transferase M1 (GSTM1) gene is reported to be involved in glaucoma, an eye disease with a largely unknown mechanism. The gene is polymorphic and three alleles have been characterized...
  67. ncbi Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men
    Varinderpal S Dhillon
    CSIRO Human Nutrition, Adelaide, Australia
    Mol Hum Reprod 13:213-22. 2007
    Methylenetetrahydrofolate (MTHFR) and DNMT3b play imperative roles in DNA synthesis and de novo methylation. GSTM1 is involved in detoxification of carcinogens...
  68. doi An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a HuGE review
    Zengnan Mo
    Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People s Republic of China
    Prostate 69:662-88. 2009
    It has been postulated that individuals with GSTM1, GSTT1 deficiency and, GSTP1 (105Ile/Val transition) have increased susceptibility to carcinogens and are more likely to develop prostate cancer...
  69. pmc GSTM1, GSTT1, GSTP1, and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans
    Susan E Steck
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    J Nutr 137:904-9. 2007
    ..DNA was extracted from blood samples, and GSTM1 deletion, GSTT1 deletion, GSTP1 Ile105Val, and GSTA1*A/*B were genotyped by matrix-assisted laser desorption/..
  70. ncbi The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTM1 gene is a modifier of the GSTP1 gene
    Fumiaki Kamada
    Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
    Int Arch Allergy Immunol 144:275-86. 2007
    ..Several studies have shown that the GSTP1 geneis involved in the pathogenesis of asthma and a gene-gene interaction may occur within the GST gene superfamily...
  71. ncbi Glutathione S-transferase M1, T1, and P1 genotypes and rheumatoid arthritis
    Bo Ra Yun
    Department of Internal Medicine, Division of Rheumatology, and the Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea
    J Rheumatol 32:992-7. 2005
    ..To determine the effects of genetic polymorphisms of glutathione S-transferase (GST) M1, GSTT1, and GSTP on risk and severity of rheumatoid arthritis (RA) in a Korean population...
  72. ncbi Glutathione S-transferase M1, T1 and P1 polymorphisms: susceptibility and outcome in lung cancer patients
    Leelakumari Sreeja
    Division of Cancer Research, Regional Cancer Centre, Trivandrum 695011, India
    J Exp Ther Oncol 7:73-85. 2008
    ..We investigated whether genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes modulated lung cancer risk and affect survival among lung cancer patients...
  73. ncbi Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility
    Noriaki Sunaga
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 11:730-8. 2002
    ..the metabolism of carcinogens or in the repair of damaged DNA in lung cells, NQO1-Pro187Ser, GSTT1-positive/null, GSTM1-positive/null, CYP1A1-Ile462Val, and OGG1-Ser326Cys, were examined for association with lung adenocarcinoma risk ..
  74. ncbi Urinary 1-hydroxypyrene level relative to vehicle exhaust exposure mediated by metabolic enzyme polymorphisms
    Chun Yu Chuang
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    J Occup Health 49:140-51. 2007
    ..05 vs. 0.07 +/- 0.03 micromol/mol creatinine). The subjects with the m1/m2 or m2/m2 genotype of CYP1A1 MspI or GSTM1 deficiency had significantly higher urinary 1-OHP levels than those with other CYP1A1 MspI and GSTM1 genotypes...
  75. doi Association study between glutathione S-transferase GST-M1, GST-T1, and GST-P1 polymorphisms and tardive dyskinesia
    Seung Gul Kang
    Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
    Hum Psychopharmacol 24:55-60. 2009
    ..In the present study, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes can influence susceptibility to TD in patients with schizophrenia...
  76. doi Influence of some detoxification enzyme polymorphisms on cytogenetic biomarkers between individuals exposed to very low doses of 1,3-butadiene
    Nenad Bukvic
    Department of Internal and Public Medicine, Section of Medical Genetics, University of Bari, Bari, Italy
    J Occup Environ Med 51:811-21. 2009
    ..To evaluate the variation of some biomarkers related to the level of enzymatic activity dependent on the different polymorphisms...
  77. doi Polymorphisms of glutathione S-transferase mu 1, theta 1, and pi 1 genes and prognosis in Hodgkin lymphoma
    Gustavo J Lourenco
    Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, Sao Paulo, Brazil
    Leuk Lymphoma 51:2215-21. 2010
    We examined the influence of the glutathione S-transferase mu 1 (GSTM1), theta 1 (GSTT1), and pi 1 (GSTP1) polymorphisms, which are involved in the metabolism of alkylating agents and anthracyclines, on the outcome of patients with ..
  78. pmc Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles: gene-by-drug-by-environment interaction
    Joel Schwartz
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Respir Crit Care Med 172:1529-33. 2005
    ..Air pollution by particulate matter (PM) has been associated with cardiovascular deaths, although the mechanism of action is unclear. One proposed pathway is through disturbances of the autonomic control of the heart...
  79. ncbi CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people
    L Quinones
    Faculty of Medicine, Laboratory of Environmental Toxicology and School of Public Health, University of Chile, Santiago, Chile
    Cancer Lett 174:35-44. 2001
    CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients...
  80. ncbi A population-based study of glutathione S-transferase M1, T1 and P1 genotypes and risk for lung cancer
    Valle Nazar-Stewart
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97201, USA
    Lung Cancer 40:247-58. 2003
    A deletion polymorphism for glutathione S-transferase M1 (GSTM1) has been related to risk for lung cancer among smokers in some studies but not in others...
  81. ncbi Genetic susceptibility and dietary patterns in lung cancer
    Ya Yu Tsai
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Lung Cancer 41:269-81. 2003
    ..16, 95%CI: 0.04-0.57). Among smokers who were GSTM1 null, persons with a healthy dietary pattern were at lower risk than persons with an unhealthy dietary pattern (OR:..
  82. ncbi Association of the NAD(P)H: quinone oxidoreductase C609T polymorphism and the risk of cervical cancer in Japanese subjects
    Yoshimitsu Niwa
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gynecol Oncol 96:423-9. 2005
    In this study, genetic polymorphisms, NQO1 C609T, GSTM1 positive/null, and GSTT1 positive/null, were examined with reference to cervical cancer risk in a population-based incident case-control study in Japanese.
  83. doi Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population
    Hariom Singh
    Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Am J Obstet Gynecol 198:303.e1-6. 2008
    The objective of the study was to evaluate the influence of genetic polymorphisms of GSTM1, GSTT1, and GSTM3 on the susceptibility of cervical cancer.
  84. doi High-throughput genotyping of copy number variation in glutathione S-transferases M1 and T1 using real-time PCR in 20,687 individuals
    Marianne S Nørskov
    Department of Clinical Biochemistry, KB 3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Clin Biochem 42:201-9. 2009
    ..We report an optimized method for the determination of copy number variation (CNV) in GST genes...
  85. doi Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China
    Dong Kui Song
    Department of Urology, First Affiliated Hospital, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China
    Cancer Detect Prev 32:416-23. 2009
    ....
  86. pmc GSTM1 and GSTT1 polymorphisms and nasopharyngeal cancer risk: an evidence-based meta-analysis
    Xianlu Zhuo
    Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, PR China
    J Exp Clin Cancer Res 28:46. 2009
    Previous evidence implicates polymorphisms of GSTM1 and GSTT1, candidates of phase II enzymes, as risk factors for various cancers...
  87. ncbi Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritis
    P Bohanec Grabar
    Institute of Biochemistry, Faculty of Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Clin Exp Rheumatol 27:229-36. 2009
    Glutathione S-transferases (GST); GST-mu1 (GSTM1), GST-pi1 (GSTP1) and GST-theta1 (GSTT1) have peroxidase activity towards cytotoxic metabolites produced in inflammatory reactions, the main feature of rheumatoid arthritis (RA)...
  88. doi Gene-smoking interaction on colorectal adenoma and cancer risk: review and meta-analysis
    Sara Raimondi
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy
    Mutat Res 670:6-14. 2009
    ..the evidence from the literature on the interaction of smoking with the five most studied gene polymorphisms (GSTM1, GSTT1, mEH3, mEH4, NAT2)...
  89. doi NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma
    Yu Fen Li
    Institute of Environmental Health, China Medical University, 91 Hsieh Shih Road, Taichung 404, Taiwan
    Mutat Res 678:53-8. 2009
    ..To investigate the genetic and environmental associations with asthma, GSTM1 and NQO1 functional polymorphisms and ETS were analyzed in a two-staged cross-sectional study among elementary ..
  90. pmc Genetic polymorphisms in genes encoding antioxidant enzymes are associated with diabetic retinopathy in type 1 diabetes
    Tinka Hovnik
    Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children s Hospital, University Medical Centre, Ljubljana, Slovenia
    Diabetes Care 32:2258-62. 2009
    ..We investigated polymorphic markers in genes encoding enzymes regulating production of reactive oxygen species in association with diabetic retinopathy or diabetic nephropathy...
  91. doi GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, National University of Athens, Athens, Greece
    Breast Cancer Res Treat 121:195-202. 2010
    Cytosolic glutathione S-transferase comprises multiple isoenzymes; studies have principally examined mu-1 (GSTM1: null/present), theta-1 (GSTT1: null/present) and pi-1 (GSTP1 Ile105Val) gene polymorphisms concerning breast cancer risk...
  92. doi Glutathione S-transferase M1 null genotype associated with gastric cancer among Asians
    Hong Wang
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    Dig Dis Sci 55:1824-30. 2010
    ..Studies investigating the association between Glutathione S-transferase M1 (GSTM1) null genotype and gastric cancer risk report conflicting results...
  93. pmc The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 124:1222-1228.e5. 2009
    The glutathione-S-transferase Mu 1 (GSTM1) null genotype has been reported to be a risk factor for acute respiratory disease associated with increases in ambient air ozone levels...
  94. ncbi Meta-analysis study of glutathione-S-transferases (GSTM1, GSTP1, and GSTT1) gene polymorphisms and risk of acute myeloid leukemia
    Prabhavathy Das
    Mahavir Hospital and Research Centre, Masab tank, Andhra Pradesh, India
    Leuk Lymphoma 50:1345-51. 2009
    ..Overall, the random-effects OR with GSTM1 null genotype, GSTP1 Val105 allele and GSTT1 null genotype were 1.30 (95% confidence intervals (CI) 1.04-1...
  95. doi Glutathione S-transferase M1 polymorphism and breast cancer susceptibility: a meta-analysis involving 46,281 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 121:703-8. 2010
    Published data on the association between present/null polymorphism of glutathione S-transferase M1 (GSTM1) and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed...
  96. doi Interaction between glutathione-S-transferase polymorphisms, smoking habit, and HPV infection in cervical cancer risk
    Selena Palma
    Section Toxicology and Biomedical Sciences, C R ENEA Casaccia, Via Anguillarese 301, 00123 Rome, Italy
    J Cancer Res Clin Oncol 136:1101-9. 2010
    ..The aim of this study was to investigate whether some GST polymorphisms could influence the risk to develop CC, either by themselves or in combination with smoking habit, in a cohort of high-risk HPV (HR-HPV) infected Italian women...
  97. doi Role of glutathione S-transferase Mu-1 (GSTM1) polymorphism in oligospermic infertile males
    G Tirumala Vani
    Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad, India
    Andrologia 42:213-7. 2010
    The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility...
  98. doi GSTM1 polymorphism, GSTT1 polymorphism, and cervical cancer risk: a meta-analysis
    Konstantinos P Economopoulos
    Department of Obstetrics and Gynecology, Aretaieio University Hospital, Athens, Greece
    Int J Gynecol Cancer 20:1576-80. 2010
    A debate exists about whether glutathione S-transferase (GST) polymorphisms (GST mu-1 [GSTM1] null/present genotype and GST theta-1 [GSTT1] null/present genotype) confer additional risk for cervical cancer...
  99. ncbi Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review
    Lawrence S Engel
    Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Am J Epidemiol 156:95-109. 2002
    Smoking is a known risk factor for bladder cancer. The product of the GSTM1 gene, glutathione S-transferase M1 (GSTM1), is involved in the detoxification of polycyclic aromatic hydrocarbons found in tobacco smoke; a homozygous deletion ..
  100. ncbi Association of NAT and GST polymorphisms with non-Hodgkin's lymphoma: a population-based case-control study
    Brian C H Chiu
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 4402, USA
    Br J Haematol 128:610-5. 2005
    ..4; 0.8-2.4). There was no association with the GSTM1 or GSTT1 null genotype in either sex, irrespective of histological subtypes...
  101. ncbi Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6 Canada
    Am J Respir Crit Care Med 166:323-8. 2002
    ..We hypothesized that polymorphisms of antioxidant genes glutathione S-transferase M1 (GSTM1), GSTT1, GSTP1, and heme oxygenase-1 (HMOX1) would be associated with susceptibility to accelerated decline of ..

Research Grants64

  1. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..We propose a randomized crossover feeding trial to identify effects of CYP1A2C734A genotypes and variants of GSTM1 and GSTT1 and cruciferous and apiaceous (i.e...
  2. Ozone Cardiovascular Effects in Genetically Susceptible People
    MARK WALTER FRAMPTON; Fiscal Year: 2012
    ..Further, subjects with genetic polymorphisms conferring reduced function in glutathione transferase M1 (GSTM1) or nuclear factor erythroid 2- related factor 2 (Nrf2), key regulators of antioxidant defenses, will show ..
  3. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
    ..M1 null-null or GSTT1 null-null genotype, and is particularly evident among those with the null genotypes of both GSTM1 and GSTT1. No protective effect was found among subjects with GSTM1-positive or GSTT1-positive genotype...
  4. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2009
    ..serum GST-[unreadable], and serum bilirubin (UGT1A1 activity);2) To compare the enzyme responses to diet by GSTM1 genotype (GSTM1+ and GSTM1null);3) To compare responses to diet between East Asian and Caucasian participants;and ..
  5. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
    ..DNA samples will be prepared from patients and controls and genotyped for specific CYP1A1, CYP1A2, CYP2E1, GSTM1 and GSTT1 polymorphisms, and the results analyzed as related to phenotype (e.g...
  6. Thu H Le; Fiscal Year: 2015
    ..We have identified the null variant of the GSTM1 gene, a member of the Nrf2 antioxidant pathway, as a modifier of hypertensive kidney disease progression...
  7. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
    ..Recruitment will initially be focused on the null and sufficient glutathione-S-transferase M1 (GSTM1) genotype and null vs...
  8. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010
    ..In addition, we will assess the role of select polymorphisms in glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1), and their potential interactions with these heavy metals in relation to ASD...
  9. Mohammad H Rahbar; Fiscal Year: 2016
    ..Furthermore, we will assess the role of select polymorphisms in GST genes (GSTM1, GSTT1, GSTP1), and their potential interactions with these OCs in relation to ASD...
  10. Beverly H Koller; Fiscal Year: 2014
    ..families, with the majority of genetic studies focused on polymorphisms in GSTP1, a member of the pi family and GSTM1 and GSTT1, members of the mu and theta families...
  11. Michelle Hernandez; Fiscal Year: 2014
    ..Healthy volunteers lacking the antioxidant enzyme, Glutathione S Transferase Mu 1 (GSTM1), suffered from increased neutrophilic airway inflammation after chamber exposure to 0...
  12. Glutathione S-Transferase Functions in Chemoprevention
    Alan Townsend; Fiscal Year: 2009
    ..these investigations with our existing single-and dual-transfected V79 cell lines that stably express human GSTP1, GSTM1, or GSTA1, alone and also in combination with human P450-1A1 or-1B1, with addition of -1A2...
  13. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
    ....
  14. GLUTATHIONE S-TRANSFERASE M AND CANCER SUSCEPTIBILITY
    MARGIE CLAPPER; Fiscal Year: 2000
    ..These findings will provide a basis for the development of new strategies for modulating detoxification enzyme activity and increasing cellular protection in individuals at increased risk for cancer. ..
  15. Polycyclic Aromatic Hydrocarbons And Male Reproductive Health
    HUEIWANG ANNA COOK JENG; Fiscal Year: 2010
    ..coke-oven workers'sperm quality, quantify PAH biomarker levels, and detect allelic variants in CYP1A1 and GSTM1 genes. Urine samples will be collected for determining PAH internal exposure levels...
  16. Pharmacogenetics of Tamoxifen and Chemotherapies and Risk of Contralateral Breast
    Jane C Figueiredo; Fiscal Year: 2010
    ..e., CYP3A5, GSTM1, GSTP1, GSTT1);anthracyclines (i.e., CYP3A5, MDR1, GSTM1, GSTP1, GSTT1) and antimetabolites (i.e...
  17. Disruption of Glutathione S-Transferase M1 in Mice
    MARGIE CLAPPER; Fiscal Year: 2006
    ..The absence of the GSTM1 gene, a member of the n class of GSTs, in approximately half of the population has raised significant debate ..
  18. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..DNA samples from mother and infant will be used to type genetic polymorphisms (CYP1A1, GSTM1, GSTT1, GSTP1, Xrcc1, XPD) relevant to the hypothesized mechanisms...
  19. David B Peden; Fiscal Year: 2016
    ..production by airway cells, with both nutritional and genetically defined antioxidant deficiencies (such as the GSTM1 null genotype) being associated with increased risk for pollutant-induced asthma exacerbation...
  20. In vivo effects of sulforaphane supplementation on normal human prostate
    Daniel W Lin; Fiscal Year: 2013
    ..extract affects pathways associated with development and/or early progression of prostate cancer and (2) whether GSTM1 genotype modifies responses to the high- sulforaphane broccoli sprout extract...
  21. EPIDEMIOLOGY OF INFANT LEUKEMIA
    Julie Ross; Fiscal Year: 2007
    ..MLL infant leukemia; b) obtain DNA from infant cases to investigate genetic polymorphisms (including NQ01, MTHFR, GSTM1, GSTT1, GSTPi, MPO, COMT, IGF1) associated with infant leukemia; c) obtain DNA from case mothers and investigate ..
  22. DIET AND GENETIC RISKS FOR LUNG CANCER
    Ruth Patterson; Fiscal Year: 2002
    ..e., CYP2D6, CYP2El, CYP1Al, GSTM1, GSTT1, and EH)...
  23. GST, ENVIRONMENT FACTORS AND BREAST CANCER RISK
    Tongzhang Zheng; Fiscal Year: 2000
    ..proposed case-control study is to examine the association between genetic variability in three major GSTs, namely, GSTM1, GSTT1, and GSTP1 and the susceptibility to breast cancer...
  24. Molecular Analysis of Esophageal Cancer Survival
    Matthew Kulke; Fiscal Year: 2007
    ..of examining the association between overall survival and the presence of specific genetic polymorphisms (GSTP1, GSTM1, GSTT1, CYP1A1, CYP3A5, p53, XRCC1 and ERCC2) in patients with esophageal cancer...
  25. Genetic Susceptibilty to Cardiovascular Effects of Arsenic Exposure
    Yu Chen; Fiscal Year: 2013
    ..whether the cardiovascular effects of As exposure differ by polymorphisms in genes related to As methylation (GSTM1, GSTT1, GSTO1, GSTP1, MTHFR, and AS3MT genes) and genes related to oxidative stress (NOS3, SOD2, and CYBA) and ..
  26. Children's Environmental Health Center
    Frank D Gilliland; Fiscal Year: 2010
    ..airway inflammation? 4) Do levels of expression or polymorphic variants of genes in antioxidant pathways such as GSTM1 confer special airway sensitivity to air pollution? 5) Which pollutants are responsible for the effects we see? 6) ..
  27. Cardiovascular Effects of Ultrafine Particles in Genetically Susceptible Subjects
    Mark W Frampton; Fiscal Year: 2010
    ..We will study 3 groups of 12 subjects each, with differing genotypes as follows: 1) GSTM1 null, 2) Nrf2 -617A/C, and 3) "wild type" for both genes (GSTM1+ and Nrf2 -617C/C)...
  28. BISPHENOL A LEVELS and ENDOMETRIOSIS RISK IN REPRODUCTIVE-AGE WOMEN
    Victoria L Holt; Fiscal Year: 2012
    ..that collected in-person interview, dietary intake assessment, anthropometric measurement, polymorphic gene (GSTM1, COMT) data and the two-year ancillary study (V...
  29. Oxidative Stress, DNA Repair & Colorectal Adenoma Risk
    Michael Goodman; Fiscal Year: 2009
    ..of potentially pro- oxidant iron intake), and genotyping for polymorphisms of five antioxidant genes (GSTT1, GSTM1, MnSOD, EC-SOD, and GPX1) and five arachidonic acid-metabolizing genes (COX-2, LOX-5, LOX-12, LOX15 and PPAR-y)...
  30. GENE-ENVIRONMENT EFFECTS AND COLON ADENOMAS
    Henry Lin; Fiscal Year: 2000
    ..The project will characterize polymorphic genes for NAT1, NAT2, GSTM1, GSTM3, GSTT1, PGHS-1, PGHS-2, and cPLA2 in all subjects...
  31. Pharmacogenetics: Breast Cancer Treatment and Prognosis
    Christine Ambrosone; Fiscal Year: 2005
    ..to controlling cancer cell death, and those in the secondary line of defense against products of oxidative stress (GSTM1, GSTT1), may also impact disease-free survival after treatment for breast cancer...
  32. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2004
    ..and other chemicals into cancer-causing intermediates; 2) Glutathione S-transferase (GST) (GSTP1, GSTT1, and GSTM1), which code for Phase II enzymes that detoxify organochlorine pesticides, nitrosoureas, CYP-activated ..
  33. REPRODUCTIVE/CONTRACEPTIVE RISK FACTORS & ENDOMETRIOSIS
    Victoria Holt; Fiscal Year: 2005
    ..and other characteristics; dietary and anthropometric measurements; and values of 4 genetic polymorphisms (GSTM1, COMT, CYP1A1, CYP1A2) will be combined with additional interview information to be collected between 48-84 months ..
  34. Busulfan conditioning: optimization, kinetics, genomics
    Koen Van Besien; Fiscal Year: 2007
    ..3.To evaluate the effect of GSTA1 and GSTM1 polymorphisms and enzyme levels on kinetics and toxicity of BU...
  35. Metabolic Polymorphisms and Survival from Brain Tumors
    Melissa Bondy; Fiscal Year: 2004
    ..We will determine the frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in 350 cases by polymerase chain reaction and restriction fragment length ..
  36. ENDOMETRIAL CANCER AND CYP1A1, GSTM1 AND POLYMORPHISMS
    Noel Weiss; Fiscal Year: 1999
    ..The genes of interest are: cytochrome P450 1A1 (CYP1A1), glutathione-S-transferases M1 (GSTM1) and T1 (GSTT1), and catechol-O-methyltransferase (COMT)...
  37. Validation of Biomarkers in Humans Exposed to PAHs
    Qingshan Qu; Fiscal Year: 2004
    ..In addition, the polymorphisms of genes, including CYP1A1, microsomal epoxide hydrolase (mEH), GSTM1, and p53 genes, will be identified to assess gene-environment interactions...
  38. Adenocarinoma of the Lung in Women
    Ann Schwartz; Fiscal Year: 2005
    ..Several studies have shown that DNA adducts, p53 mutations, CYP1A1 expression in the lung, and GSTM1 null genotypes are more frequent in females than in males...
  39. ETS Exposure and Genetics: Youth at Risk for CV Disease
    Martha Tingen; Fiscal Year: 2006
    ..Specific candidate genes involved in these biotransformation reactions include CYP1A1, GSTM1, GSTT1, and CYP2A6...
  40. PHARMACOGENETIC DETERMINANTS OF FETAL SOMATIC MUTATION
    Marjorie Romkes; Fiscal Year: 2002
    ..polymorphic enzymes involved in the metabolism of chemicals found in cigarette smoke, specifically CYP1A1, CYP2E1, GSTM1, GSTT1, NAT1*, and NAT2*...
  41. BAYESIAN BIOMARKER MODELS FOR CANCER GENETICS STUDIES
    SARAH THURSTON; Fiscal Year: 2004
    ..biomarker of smoking exposure), and genes associated with adduct formation and DNA repair (including CYP1A1 MSP1, GSTM1 and XRCC1). Currently the study has 2800 subjects, approximately half of whom are cases...
  42. Chronic respiratory effects of early life PM exposure
    Kirk Smith; Fiscal Year: 2009
    ..Variation in the genotypes of key antioxidant enzymes (e.g., GSTM1 and GSTP1) may help to identify which children are more susceptible to the effects of inhaled PM on respiratory ..
  43. Pancreas cancer analysis-SF Bay Area case-control study
    ELIZABETH HOLLY; Fiscal Year: 2005
    ..PC; and 2) to evaluate the relationships between factors in Aim 1 and previously determined polymorphisms (GSTT1, GSTM1, CYPIA1, XRCC1). Detailed data were collected for this study about each factor of interest...
  44. Prostate Microenvironmental & Prostate Cancer Progression
    June Chan; Fiscal Year: 2009
    ..e. lycopene, total carotenoids, alpha- &gamma- tocopherol, and selenium) and genotypes (i.e. MnSOD, GPX1, GSTM1, GSTT1, XRCC1, OGG1) are associated with: (Aim 1) prostate cancer clinical phenotype: (Aim 2) prostate tumor ..
  45. Determinants of Breast Cancer Survival
    Melissa Bondy; Fiscal Year: 2006
    ..in genes that modulate host sensitivity to therapeutic agents, including the glutathione sulfotransferase (GSTpi, GSTM1, GSTT1); enzymes important in defending against chemical injury by catalyzing conjugation of reactive ..
  46. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
    ..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
  47. LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS
    Jenny Mao; Fiscal Year: 2007
    ..fluid, expression of Cox-2, EGFR, p27,p16, bcl-2, apoptosis index, cyclin D1 and E, GSTP1 methylation, GSTP1, GSTM1 and CYP1A1 polymorphisms, P53 polymorphisms and p16 methylation; 2) regulation of arachidonic acid metabolism; 3) ..
  48. Genes, OP Pesticides, and Reproductive Health
    Scott Venners; Fiscal Year: 2007
    ..both to metabolism of organophosphate pesticide and endocrine function including: CYP3A4, PON1, PON2, PON3, GSTM1, BCHE, ESR1, GnRHR LHCGR, and FSHR. Dr...
  49. Microarray-based genotyping for studying susceptibility to mesothelioma
    Stefano Landi; Fiscal Year: 2007
    ..For example, previous studies showed a higher risk for people with GSTM1 null genotype and NAT2 slow acetylators The aim of the present project is to dissect the influence of genes in the ..
  50. Using Tobacco Biomarkers to Improve Smoking Cessation Rates
    Stephen Wilson; Fiscal Year: 2009
    ..influence racial differences in DNA adducts, we will explore whether polymorphisms in 4 candidate genes (GSTM1, GSTT1, GSTP1, and NAT2) modify the relationship between African American race and WBC DNA adducts...
  51. COHORT STUDY OF GENETIC MARKERS IN COLON CANCER
    David Hunter; Fiscal Year: 2005
    ..genes the investigators will assay are N-acetyltransferase 2, N-acetyltransferase 1, glutathione S-transferase M1 (GSTM1) and CYP1A1...
  52. Drug Metabolism, DNA Repair & Second Cancers
    Debra Friedman; Fiscal Year: 2003
    ..chosen for study include methylenetetrahydrofolate reductase (MTHFR), Glutathione-S-transferase (GST), GSTT1, GSTM1, GSTM3, GSTP1, Cytochrome P-450 (CYP) CYP2C9, CYP2C19, CYP3A4, thiopurine methyltransferase, methylguanine DNA ..
  53. Molecular Epidemiology of Myelodysplastic Syndromes
    Sara Strom; Fiscal Year: 2002
    ..markers associated with activation and detoxification of chemical carcinogens (CYP2E1, CYP1A1, CYP1B1, GSTT1, GSTM1, GSTP1, NQO1, and MPO)...
  54. ENVIRONMENTAL RISK FACTORS AND BREAST CANCER IN MARYLAND
    Kathy Helzlsouer; Fiscal Year: 1993
    ..carcinogenic exposures (organochlorine compounds), a potential susceptibility factor (Glutathione S Transferase (GSTM1 genotype), and protective factors (antioxidants) on the risk of breast cancer...
  55. Gene-gene interaction in nasopharyngeal carcinoma
    YIN YAO; Fiscal Year: 2005
    ..stability and function of 5 CYP genes (CYP1A1, CYP1A2, CYP2D6, CYP2E1, CYP1B1) and a few other polymorphisms (GSTM1, GSTT1, NQO1, NAT1 and NAT2) contribute to the development of NPC and to test for the interaction with high risk ..
  56. MOLECULAR MARKERS OF ORAL CANCER RISK
    Philip Lazarus; Fiscal Year: 2000
    ..The most well-defined correlation for susceptibility to tobacco-induced cancers is the null GSTM1 genotype and lung cancer...
  57. GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS
    Brian Henderson; Fiscal Year: 2000
    ..Specifically, this proposal will investigate polymorphisms in candidate genes (NAT2, GSTM1, CYP1A1, SRD5A2, AR, EDH17B2, CYP17, and ER), that might alter metabolism of relevant endogenous or exogenous ..
  58. SUSCEPTIBILITY TO MOLECULAR ALTERATION: EPITHELIAL CELLS
    Charles Powell; Fiscal Year: 2003
    ..Polymorphisms of CYP1A1 and GSTM1 and dietary intake of vitamins and carotenoids will be characterized...
  59. Carcinogen Metabolism Enzyme Expression in Buccal Cells
    SIMON SPIVACK; Fiscal Year: 2003
    ..gene expression of a panel of carcinogen metabolizing enzymes in buccal mucosa, including Ahr, ER, CYP1B1, CYP1A1, GSTM1, GSTM3, GSTP1, GSTT1, NQO1...
  60. TOBACCO METABOLISM GENES AND GASTRIC CANCER
    Anna Wu; Fiscal Year: 1999
    ..we will test the hypotheses that the risk of gastric cancer is increased among individuals who: a) possess the GSTM1 null, the GSTT1 null and/or the GSTP1 GG genotypes; and b) carry mutant CYP1A1 alleles...
  61. GENE-ENVIRONMENT INTERACTIONS: THE ODYSSEY COHORT
    Sandra Hoffman; Fiscal Year: 2003
    ..metabolize nutrients and hormones (MTHFR, VDR, CYP17, CYP1B1, COMT, CYP3A4 ); 2) metabolize carcinogens (ADH, GSTM1, GSTT1, GSTP1, NAT1 and NAT2, NOS, CYP1A1, CYP1B1, EH); and 3) control DNA repair processes (XRCC1, XRCC3, XPD)...
  62. Genetic epidemiology of glutathione and CF lung disease
    EDWARD MCKONE; Fiscal Year: 2005
    ..abstract_text> ..
  63. A Genome-wide Association Study of Childhood Respiratory Outcomes
    WILLIAM GAUDERMAN; Fiscal Year: 2009
    ..with ozone, particulate matter, traffic exposure, or passive tobacco smoke), and gene-gene interaction (with GSTM1) in the search for new genetic variants...
  64. Alpha-1 AD Carriers and Lung Cancer Risk
    Ping Yang; Fiscal Year: 2009
    ..abstract_text> ..