GSPT2

Summary

Gene Symbol: GSPT2
Description: G1 to S phase transition 2
Alias: ERF3B, GST2, eukaryotic peptide chain release factor GTP-binding subunit ERF3B, eukaryotic peptide chain release factor subunit 3b
Species: human

Top Publications

  1. pmc Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
    Isao Kashima
    Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    Genes Dev 20:355-67. 2006
  2. pmc Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation
    Celine Chauvin
    Unite de Biochimie Cellulaire, UMR 7098 CNRS Université Paris 6, 9 quai Saint Bernard, 75252 Paris Cedex 05, France
    Mol Cell Biol 25:5801-11. 2005
  3. pmc Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase
    Guennadi Kozlov
    Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada
    EMBO J 23:272-81. 2004
  4. ncbi Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1
    S Hoshino
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 273:22254-9. 1998
  5. ncbi Insect glutathione S-transferases. Biochemical characteristics of the major forms from houseflies susceptible and resistant to insecticides
    D Fournier
    Institut National de la Recherche Agronomique, Antibes, France
    J Biol Chem 267:1840-5. 1992
  6. doi A Ve homologous gene from Gossypium barbadense, Gbvdr3, enhances the defense response against Verticillium dahliae
    Tianzi Chen
    Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China
    Plant Physiol Biochem 98:101-11. 2016
  7. ncbi GST2 is required for nitrogen starvation-induced filamentous growth in Candida albicans
    So Hyoung Lee
    Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul 151 921, Republic of Korea
    J Microbiol Biotechnol 24:1207-15. 2014
  8. pmc Characterization of affinity-purified isoforms of Acinetobacter calcoaceticus Y1 glutathione transferases
    Chin Soon Chee
    Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    ScientificWorldJournal 2014:750317. 2014
  9. doi In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants
    Valeria Righi
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 34:327-33. 2014
  10. doi The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor
    Yoshifumi Hashimoto
    Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Biochem Biophys Res Commun 445:639-44. 2014

Scientific Experts

  • Shinichi Hoshino
  • Kazumi Hoshino
  • Markus Perbandt
  • Anja Joachim
  • Lise Lotte Hansen
  • D A Dalton
  • U Mansmann
  • Kenneth Pfarr
  • G Zhouravleva
  • Julius Gudmundsson
  • Celine Chauvin
  • Tianzi Chen
  • Valeria Righi
  • Yoshifumi Hashimoto
  • Jin Xu
  • Chin Soon Chee
  • So Hyoung Lee
  • Man Li
  • S Sherif
  • Ruilin Xiao
  • Kai Lieh Huang
  • Ji Wang
  • Gezi Li
  • Hong Su
  • Paulina Kober
  • Hyun Sub Cheong
  • Jitao Wang
  • Xiu li Lin
  • Annabel C Whibley
  • Young Sang Kwon
  • Catherine Le Goff
  • Zhihong Cheng
  • Hyun Woo Ju
  • Guramrit Singh
  • Joyce E Royland
  • G A Zhuravleva
  • Mitra Mazarei
  • Krisztina Takács
  • Samia Salhi
  • Abdel Monem Abdalla
  • Olivier Jean-Jean
  • Isao Kashima
  • Joern Groene
  • Archana Thakur
  • J Höppner
  • Guennadi Kozlov
  • Xitie Ling
  • Youhong Chang
  • Baolong Zhang
  • Yuwen Yang
  • Jialiang Kan
  • Lei Yang
  • Yiorgos Apidianakis
  • Soon Chun Chung
  • Tingjin Chen
  • Nao Hosoda
  • Irene Kit Ping Tan
  • Lexun Wang
  • Qing Bao Tian
  • Chuanhuan Deng
  • Nikolaos Psychogios
  • Elizabeth A Veal
  • Ran Li
  • Xuchu Hu
  • Laurence G Rahme
  • Zhongdao Wu
  • Yingsong Wu
  • Dian wu Liu
  • Xuerong Li
  • Jian Wang
  • Jongheon Shin
  • A Aria Tzika
  • Ronald G Tompkins
  • Zazali Alias
  • Jocelyn R Grunwell
  • Naomichi Kumagai
  • Ping Gao
  • Ki Bong Oh
  • Xinbing Yu
  • Dan Ning
  • Yan Huang
  • Yonglong Li
  • Yanfei Zheng
  • Chyi Ying A Chen
  • Huimin Zhang
  • LingLing Yang
  • Liting Wei
  • Xiaoqi Peng
  • I El-Sharkawy
  • S Jayasankar

Detail Information

Publications59

  1. pmc Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
    Isao Kashima
    Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    Genes Dev 20:355-67. 2006
    ..Thus, the SMG-1-mediated phosphorylation of Upf1 occurs on the association of SURF with EJC, which provides the link between the EJC and recognition of PTCs and triggers NMD...
  2. pmc Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation
    Celine Chauvin
    Unite de Biochimie Cellulaire, UMR 7098 CNRS Université Paris 6, 9 quai Saint Bernard, 75252 Paris Cedex 05, France
    Mol Cell Biol 25:5801-11. 2005
    ..In mammals, two genes encode two distinct forms of eRF3, eRF3a and eRF3b, which differ in their N-terminal domains. Both bind eRF1 and stimulate its release activity in vitro...
  3. pmc Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase
    Guennadi Kozlov
    Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada
    EMBO J 23:272-81. 2004
    ..The results provide insight into the specificity of PABC in mediating PABP-protein interactions...
  4. ncbi Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1
    S Hoshino
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 273:22254-9. 1998
    ..we isolated two mouse GSPT genes, the counterpart of human GSPT1 and a novel member of the GSPT gene family, GSPT2. Both the mouse GSPTs had a two-domain structure characterized as an amino-terminal no-homologous region (..
  5. ncbi Insect glutathione S-transferases. Biochemical characteristics of the major forms from houseflies susceptible and resistant to insecticides
    D Fournier
    Institut National de la Recherche Agronomique, Antibes, France
    J Biol Chem 267:1840-5. 1992
    ..designated as GST1, migrates as a single band of 28 kDa in SDS-gel electrophoresis, and the second, designated as GST2, migrates as a 32-kDa band...
  6. doi A Ve homologous gene from Gossypium barbadense, Gbvdr3, enhances the defense response against Verticillium dahliae
    Tianzi Chen
    Provincial Key Laboratory of Agrobiology, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China
    Plant Physiol Biochem 98:101-11. 2016
    ..of Gbvdr3 in transgenic Arabidopsis, which significantly elevated the expression of the ethylene-regulated gene GST2, the ethylene- and jasmonic acid-regulated defense-related genes PR3 and PDF1...
  7. ncbi GST2 is required for nitrogen starvation-induced filamentous growth in Candida albicans
    So Hyoung Lee
    Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul 151 921, Republic of Korea
    J Microbiol Biotechnol 24:1207-15. 2014
    ..In this study, we identified a new function of GST2, whose expression was required for filamentous growth of C. albicans under nitrogen-limiting conditions...
  8. pmc Characterization of affinity-purified isoforms of Acinetobacter calcoaceticus Y1 glutathione transferases
    Chin Soon Chee
    Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
    ScientificWorldJournal 2014:750317. 2014
    ..2-dimensional (2-D) gel electrophoresis showed the presence of two isoforms, GST1 (pI 4.5) and GST2 (pI 6.2) with identical MW...
  9. doi In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants
    Valeria Righi
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 34:327-33. 2014
    ..We used a novel high-resolution magic angle-spinning (HRMAS) NMR method to investigate live Drosophila GST2 mutants using a conventional 14.1-T NMR spectrometer equipped with an HRMAS probe...
  10. doi The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor
    Yoshifumi Hashimoto
    Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Biochem Biophys Res Commun 445:639-44. 2014
    ..These results suggest that while p-eRF3 interacts with IAPs to promote apoptosis in the cytoplasm, p-eRF3 also has some roles in regulating cell death in the nucleus. ..
  11. pmc eRF3b, a biomarker for hepatocellular carcinoma, influences cell cycle and phosphoralation status of 4E-BP1
    Man Li
    Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang, Hebei Province, China
    PLoS ONE 9:e86371. 2014
    ..Hepatitis B virus (HBV) infection and its sequelae are now recognized as serious problems globally. Our aime is to screen hepatocellular carcinoma (HCC) from chronic hepatitis B (CHB) and identify the characteristics of proteins involved...
  12. doi Polypeptide chain release factor eRF3 is a novel molecular partner of survivin
    Ruilin Xiao
    Key Laboratory of Chemical Biology and Molecular Engineering, Ministry of Education, China Institute of Biotechnology, Shanxi University, Taiyuan 030006, China
    Cell Biol Int 37:359-69. 2013
    ..Interaction between survivin and eRF3a-F3 or eRF3b, encoded by the GSPT1 and GSPT2 genes, respectively, was confirmed using yeast two-hybrid (Y2H) and pull-down ..
  13. pmc Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate
    Kai Lieh Huang
    Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, Texas 77030, USA
    RNA 19:295-305. 2013
    ..Taken together, these results provide a new framework for understanding the roles of intrinsically disordered proteins in the dynamic and signal-dependent control of cytoplasmic mRNA functions...
  14. doi The serological diagnosis of human clonorchiasis by time-resolved fluoroimmunoassay based on GST2-specific IgG4 detection
    Jin Xu
    Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    Parasitol Res 113:149-55. 2014
    ..Kappa score of agreement between TRFIA and microscopic examination of stools was 0.892, P < 0.05. These combined results showed that our method is feasible and could be used for the clinical determination of clonorchiasis...
  15. ncbi [Conservation of the MC domains in eukaryotic termination factor eRF3]
    G A Zhuravleva
    Genetika 43:38-44. 2007
    ..The MC domains of Homo sapiens eRF3a (hGSPT I), Xenopus laevis eRF3 (XSup35), and Mus musculus eRF3a (mGSPTI) and eRF3b (mGSPT2) were found to compensate for the sup35-21(ts) temperature-sensitive mutation and lethal disruption of the ..
  16. ncbi The human glutathione S-transferases: studies on the tissue distribution and genetic variation of the GST1, GST2 and GST3 isozymes
    R C Strange
    Ann Hum Genet 48:11-20. 1984
    ..The GST2 isozymes also exhibit variant patterns but these are probably due to post-synthetic modification rather than ..
  17. ncbi [Immunochemical properties and immunohistological localization of human liver glutathione S-transferase isozymes]
    M Abei
    Nihon Shokakibyo Gakkai Zasshi 86:2728-34. 1989
    The products of three human glutathione S-transferase (GST) loci (GST1, GST2 and GST3) were purified and their immunochemical properties as well as immunohistological localization in liver were studied...
  18. ncbi Crystallization of the major cytosolic glutathione S-transferase from Onchocerca volvulus
    J Höppner
    Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Acta Crystallogr D Biol Crystallogr 60:1496-7. 2004
    ..The recombinant Onchocerca volvulus GST2 has been expressed in Escherichia coli, purified and crystallized by the hanging-drop vapour-diffusion technique...
  19. ncbi Development of the gerotranscendence scale type 2: Japanese version
    Kazumi Hoshino
    Institute of Personality and Social Research, University of California, Berkeley, CA 94720 5050, USA
    Int J Aging Hum Dev 75:217-37. 2012
    This study developed the Japanese version of the gerotranscendence scale type 2 (the GST2) and examined reliability and validity of the scale...
  20. ncbi Human genes for glutathione S-transferases
    V Laisney
    Hum Genet 68:221-7. 1984
    ..The existence of GST"e" (erythrocyte), GST3, GST1, and GST2 is confirmed...
  21. pmc Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing
    Hong Su
    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA
    Mol Cell 43:97-109. 2011
    ..Among the PABC-interactors, DDX6 and Tob1/2 are both required and sufficient for silencing mRNA targets. Taken together, these data demonstrate a critical function for EDD in miRNA silencing...
  22. ncbi The role of X-linked genes in breast cancer
    Archana Thakur
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Breast Cancer Res Treat 93:135-43. 2005
    ..g., CENP-I and smc111) and, ribosomal biogenesis and translational control (e.g., Dkc1, Rpl44, Rpl39, Eif2s3x, Gspt2 and Rsk4)...
  23. doi Salicylic acid increases the contents of glutathione and ascorbate and temporally regulates the related gene expression in salt-stressed wheat seedlings
    Gezi Li
    The National Engineering Research Centre for Wheat, The Key Laboratory of Physiology, Ecology and Genetic Improvement of Food Crops in Henan Province, Henan Agricultural University, Zhengzhou 450002, China
    Gene 529:321-5. 2013
    ..DHAR) genes at 12h, glutathione reductase (GR) at 24h, 48h and 72h, glutathione-S-transferase 1 (GST1), 2 (GST2), monodehydroascorbate reductase (MDHAR) and glutathione synthetase (GS) at the 48h and 72h after salt stress, ..
  24. doi Phlegm-dampness constitution: genomics, susceptibility, adjustment and treatment with traditional Chinese medicine
    Ji Wang
    Center for Studies in Constitution Research of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
    Am J Chin Med 41:253-62. 2013
    ..Genomics studies found four upregulated genes: COPS8, GNPDA1, CD52 and ARPC3; and six downregulated genes: GSPT2, CACNB2, FLJ20584, UXS1, IL21R and TNPO in the phlegm-dampness constitution...
  25. doi PpERF3b, a transcriptional repressor from peach, contributes to disease susceptibility and side branching in EAR-dependent and -independent fashions
    S Sherif
    Department of Plant Agriculture, University of Guelph, 4890 Victoria Av N, PO Box 7000, Vineland Station, ON L0R 2E0, Canada
    Plant Cell Rep 32:1111-24. 2013
    Peach ERF3b is a potent transcriptional repressor for defense-related genes even in the presence of similar levels of transcriptional activators and can interfere with plant development through pathways independent of the EAR motif...
  26. doi Epigenetic modification of retinoic acid-treated human embryonic stem cells
    Hyun Sub Cheong
    Department of Genetic Epidemiology, SNP Genetics, Inc, Seoul 153 803, Korea
    BMB Rep 43:830-5. 2010
    ..19 genes (STAP2, VAMP8, C10orf26, WFIKKN1, ELF3, C1QTNF6, C10orf10, MRGPRF, ARSE, LSAMP, CENTD3, LDB2, POU5F1, GSPT2, THY1, ZNF574, MSX1, SCMH1, and RARB) were highly correlated with each other...
  27. pmc Structural insights into eRF3 and stop codon recognition by eRF1
    Zhihong Cheng
    Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research A STAR, Singapore, Singapore
    Genes Dev 23:1106-18. 2009
    ..An ATP molecule used as a crystallization additive was bound in eRF1's putative decoding area. Mutational analysis of the ATP-binding site shed light on the mechanism of stop codon recognition by eRF1...
  28. doi Proteome analysis of Arabidopsis seedlings exposed to bacterial volatiles
    Young Sang Kwon
    Department of Applied Biology and Research Institute of Life Science, Gyeongsang National University, Jinju, 660 701, South Korea
    Planta 232:1355-70. 2010
    ..that ethylene biosynthesis-related genes SAM-2, ACS4, ACS12, and ACO2 as well as ethylene response genes, ERF1, GST2, and CHIB were up-regulated by the exposure to bacterial volatiles...
  29. pmc Fine-scale survey of X chromosome copy number variants and indels underlying intellectual disability
    Annabel C Whibley
    Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge CB2 0XY, UK
    Am J Hum Genet 87:173-88. 2010
    ..analysis of rare variants in XLID families leads us to propose four additional genes, PTCHD1, WDR13, FAAH2, and GSPT2, as candidates for XLID causation and the identification of further deletions and duplications affecting X ..
  30. doi The different responses of glutathione-dependent detoxification pathway to fungicide chlorothalonil and carbendazim in tomato leaves
    Jitao Wang
    Department of Horticulture, Huajiachi Campus, Zhejiang University, Kaixuan Road 268, Hangzhou 310029, China
    Chemosphere 79:958-65. 2010
    ..and glutathione reductase (GR), as well as the transcriptional levels of glutathione S-transferase genes (GST1, GST2 and GST3), glutathione synthetase gene (GSH), glutathione reductase gene (GR) and glutathione peroxidase gene (GPX) ..
  31. ncbi Detection of lung adenocarcinoma using magnetic beads based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry serum protein profiling
    Xiu li Lin
    Department of Respiratory Medicine, Second Affiliated Hospital of Medical College of Xi an Jiao Tong University, Xi an, Shaanxi 710004, China
    Chin Med J (Engl) 123:34-9. 2010
    ....
  32. doi Cytosolic glutathione S-transferases of Oesophagostomum dentatum
    A Joachim
    Institute of Parasitology and Zoology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, A 1210 Vienna, Austria
    Parasitology 135:1215-23. 2008
    ..GST sequences of other nematodes for complete cDNA sequences (621 and 624 nt) of 2 isoforms, Od-GST1 and Od-GST2, with 72% nucleotide similarity and 75% for the deduced proteins...
  33. doi Methyl-CpG binding column-based identification of nine genes hypermethylated in colorectal cancer
    Paulina Kober
    Department of Molecular Biology, Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    Mol Carcinog 50:846-56. 2011
    ..41% of CRC patients), GPR101 (40%), CDH2 (45%), BARX1 (56%), CNTFR (22%), SYT6 (64%), SMO (21%), EPHA5 (43%), and GSPT2 (21%)...
  34. ncbi Immunocytochemical evidence for the expression of GST1, GST2, and GST3 gene loci for glutathione S-transferase in human lung
    Y C Awasthi
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550
    Lung 165:323-32. 1987
    ..of human liver and GST pi of human placenta indicating that the isoenzymes corresponding to three gene loci, GST1, GST2, and GST3 are present in human lung...
  35. ncbi Immunohistochemical localization of human liver glutathione S-transferase (GST) isozymes with special reference to polymorphic GST1
    M Abei
    Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan
    Biochim Biophys Acta 995:279-84. 1989
    ..However, none of the hepatic tissue showing GST1 0 phenotype was stained. Immunohistochemical staining of GST2 (basic isozyme) was distributed in the cytoplasm of hepatocytes homogeneously throughout the hepatic lobule in all ..
  36. pmc The contribution of the C-terminal sequence to the catalytic activity of GST2, a human alpha-class glutathione transferase
    P G Board
    Molecular Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra, A C T
    Biochem J 275:171-4. 1991
    A plasmid vector was constructed that encodes the expression in Escherichia coli of a truncated form of GST2, a human Alpha-class glutathione transferase...
  37. ncbi Purification and characterization of human muscle glutathione S-transferases: evidence that glutathione S-transferase zeta corresponds to a locus distinct from GST1, GST2, and GST3
    S S Singhal
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550
    Arch Biochem Biophys 285:64-73. 1991
    ..These studies suggest that GST zeta corresponds to a locus distinct from GST1, GST2, and GST3 and probably corresponds to the GST4 locus as suggested previously by Laisney et al. (1984, Human Genet...
  38. ncbi The human glutathione S-transferases: comparison of isoenzyme expression in normal and astrocytoma brain
    R C Strange
    Clinical Biochemistry Research Laboratory, School of Postgraduate Medicine and Biological Sciences, University of Keele, North Staffordshire Hospital Centre, Hartshill, Stoke on Trent, UK
    Biochim Biophys Acta 1139:222-8. 1992
    ..GST were sequentially resolved by chromatofocusing into the GST2, GST1, GST5, GST2 (5.5), GST3, GST6 sets and the contribution of each to total activity determined...
  39. ncbi Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and III
    Joern Groene
    Department of General, Vascular and Thoracic Surgery, Campus Benjamin Franklin, Charite Universitaetsmedizin, Berlin, Germany
    Int J Cancer 119:1829-36. 2006
    ..The most distinctive elements in this signature were the gene GSTP-binding elongation factor (GSPT2) and the transcription factor HOXA9...
  40. ncbi Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23-->p11.21 and of the distal marker DXS1039 by radiation hybrid mapping
    L L Hansen
    Institute of Human Genetics, Aarhus University, Aarhus, Denmark
    Cytogenet Cell Genet 86:250-1. 1999
  41. ncbi Distinct roles for glutathione S-transferases in the oxidative stress response in Schizosaccharomyces pombe
    Elizabeth A Veal
    School of Biochemistry and Genetics, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 277:35523-31. 2002
    We have identified three genes, gst1(+), gst2(+), and gst3(+), encoding theta-class glutathione S-transferases (GSTs) in Schizosaccharomyces pombe. The gst1(+) and gst2(+) genes encode closely related proteins (79% identical)...
  42. ncbi Mouse GSPT2, but not GSPT1, can substitute for yeast eRF3 in vivo
    Catherine Le Goff
    Universite de Rennes 1, CNRS UMR 6061, IFR 97, 2 av Pr Léon Bernard 35043 Rennes Cedex, France
    Genes Cells 7:1043-57. 2002
    The termination of protein synthesis in eukaryotes involves at least two polypeptide release factors (eRFs), eRF1 and eRF3. In mammals two genes encoding eRF3 structural homologues were identified and named GSPT1 and GSPT2.
  43. ncbi Characterization and mutagenesis of Gal/GlcNAc-6-O-sulfotransferases
    Jocelyn R Grunwell
    Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    Biochemistry 41:15590-600. 2002
    ..used these tools to perform the first site-directed mutagenesis study of a member of this sulfotransferase family, GST2. Using sequence alignments with other carbohydrate and cytosolic sulfotransferases, we selected residues within the ..
  44. pmc The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4
    P Thompson
    Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Virol 72:3751-61. 1998
    ..region in Escherichia coli fused to glutathione S-transferase and generated antibodies (Ab) in rabbits (anti-GST2 Ab)...
  45. ncbi Structure of the major cytosolic glutathione S-transferase from the parasitic nematode Onchocerca volvulus
    Markus Perbandt
    Institute of Biochemistry and Foodchemistry, Department of Biochemistry and MolecularBiology, University of Hamburg, Martin Luther King Platz 6, 20146 Hamburg, Germany
    J Biol Chem 280:12630-6. 2005
    ..We analyzed the three-dimensional x-ray structure of the major cytosolic GST from O. volvulus (Ov-GST2) in complex with its natural substrate glutathione and its competitive inhibitor S-hexylglutathione at 1.5 and 1...
  46. pmc Identification of the prfC gene, which encodes peptide-chain-release factor 3 of Escherichia coli
    O Mikuni
    Department of Tumor Biology, Institute of Medical Science, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 91:5798-802. 1994
    ..A completely null prfC mutation made by reverse genetics affected the cell growth under the limited set of physiological and strain conditions...
  47. ncbi Two glutathione S-transferase isoenzymes purified from Bulinus truncatus (Gastropoda: Planorbidae)
    Abdel Monem Abdalla
    Molecular Biology Department, National Research Centre, Dokki, Cairo, Egypt
    Comp Biochem Physiol B Biochem Mol Biol 143:76-84. 2006
    We purified and characterized two major glutathione S-transferase isoenzymes (GST2 and GST3) from snail Bulinus truncatus (Mollusca, Gastropoda, Planorbidae) tissue...
  48. ncbi A surface mutant (G82R) of a human alpha-glutathione S-transferase shows decreased thermal stability and a new mode of molecular association in the crystal
    K Zeng
    Department of Crystallography and Biological Sciences, University of Pittsburgh, Pennsylvania 15260
    Proteins 20:259-63. 1994
    A chimeric enzyme (GST121) of the human alpha-glutathione S-transferases GST1-1 and GST2-2, which has improved catalytic efficiency and thermostability from its wild-type parent proteins, has been crystallized in a space group that is ..
  49. ncbi RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotype
    Kenneth Pfarr
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Int J Parasitol 36:661-9. 2006
    ..The knockdown of Ls-act was specific as Ls-hsp60 and Ls-gst2 showed no reduction in transcription...
  50. pmc Physiological roles of glutathione s-transferases in soybean root nodules
    David A Dalton
    Biology Department, Reed College, Portland, Oregon 97202, USA
    Plant Physiol 150:521-30. 2009
    ..GST8 was prevalent in stems and uninfected roots, whereas GST2/10 prevailed in leaves...
  51. ncbi Evolution of translation termination factor eRF3: is GSPT2 generated by retrotransposition of GSPT1's mRNA?
    G Zhouravleva
    Department of Genetics, St Petersburg State University, St Petersburg, Russia
    IUBMB Life 58:199-202. 2006
    ..Mammalian eRF3 exists in two isotypes, eRF3a and eRF3b, encoded by genes GSPT1 and GSPT2, respectively...
  52. ncbi Gene expressions and enzyme analyses in the Schizosaccharomyces pombe Deltapap1 transcription factor mutant exposed to Cd(2+)
    Krisztina Takács
    Department of General and Environmental Microbiology, University of Pecs, Hungary
    J Basic Microbiol 47:74-83. 2007
    ..The RT-PCR and Northern blot experiments proved that gst2 was not induced either by short-term or by long-term Cd(2+) treatment. The SPCC965...
  53. ncbi GmEREBP1 is a transcription factor activating defense genes in soybean and Arabidopsis
    Mitra Mazarei
    Department of Plant Pathology, Iowa State University, Ames 50011, USA
    Mol Plant Microbe Interact 20:107-19. 2007
    ..2 but not the ET-regulated GST2, and the SA-regulated gene PR1 but not the SA-regulated PR2 and PR5...
  54. pmc Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway
    Celine Chauvin
    Unite de Biochimie Cellulaire, UMR 7098 CNRS Université Pierre et Marie Curie, 9 quai Saint Bernard, 75252 Paris Cedex 05, France
    Mol Cell Biol 27:5619-29. 2007
    ..In mammals, two genes encode two distinct forms of eRF3, eRF3a and eRF3b, which differ in their N-terminal domains...
  55. pmc Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
    Julius Gudmundsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 40:281-3. 2008
    ..23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease...
  56. pmc A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay
    Guramrit Singh
    Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America
    PLoS Biol 6:e111. 2008
    ..We speculate that these have evolved to concentrate NMD-inhibiting factors, such as PABP, in spatial proximity of the termination codon...
  57. doi Glucosamine causes overproduction of reactive oxygen species, leading to repression of hypocotyl elongation through a hexokinase-mediated mechanism in Arabidopsis
    Hyun Woo Ju
    Department of Plant Biotechnology, Agricultural Plant Stress Research Center and Biotechnology Research Institute, College of Agriculture and Life Science, Chonnam National University, Gwangju, Korea
    J Plant Physiol 166:203-12. 2009
    ..GlcN treatment resulted in significant induction of expression of GST1, GST2 and GST6, which are marker genes for ROS production...
  58. doi Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s) of action
    Joyce E Royland
    Cellular and Molecular Toxicology Branch, Neurotoxicology Division, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, NC, USA
    Toxicol Appl Pharmacol 231:179-96. 2008
    ..Gucy1b3), aryl hydrocarbon receptor signaling (Nfia, Col1a2), and transcripts involved in cell proliferation (Gspt2, Cdkn1c, Ptk2b) and differentiation (Ifitm31, Hpca, Zfp260, Igsf4a, Hes5) leading to the development of nervous ..
  59. ncbi The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein
    S Hoshino
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 274:16677-80. 1999
    ..Thus, the present study is the first report showing that GSPT/eRF3 carries the translation termination signal to 3'-poly(A) tail ubiquitously present in eukaryotic mRNAs...