growth hormone receptor

Summary

Gene Symbol: growth hormone receptor
Description: growth hormone receptor
Alias: GHBP, GHIP, growth hormone receptor, GH receptor, growth hormone binding protein, serum binding protein, somatotropin receptor
Species: human

Top Publications

  1. ncbi The binding of different biosynthetic and extracted human growth hormones to the growth hormone-binding protein of human serum: a comparative study
    A Aguirre
    Endocrinologia, Inst. Proagro, Sucre, Bolivia
    Horm Metab Res 23:281-4. 1991
  2. ncbi Regulation of human growth hormone receptor gene transcription by human growth hormone binding protein
    P E Mullis
    Department of Paediatrics, University Childrens Hospital, Inselspital, Bern, Switzerland
    Mol Cell Endocrinol 131:89-96. 1997
  3. ncbi Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate
    Evelien F Gevers
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    J Bone Miner Res 17:1408-19. 2002
  4. doi Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes
    Yong Yang
    Chinese Academy of Medical Sciences, Department of Orthopedics, Peking Union Medical College, Beijing, China
    Orthopedics 32:411. 2009
  5. ncbi Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1
    L S Argetsinger
    Department of Physiology, University of Michigan Medical School, Ann Arbor 48109 0622, USA
    J Biol Chem 270:14685-92. 1995
  6. pmc Alternative splicing of exon 3 of the human growth hormone receptor is the result of an unusual genetic polymorphism
    M L Stallings-Mann
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 93:12394-9. 1996
  7. ncbi Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
    Richard J Brown
    Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia
    Nat Struct Mol Biol 12:814-21. 2005
  8. ncbi The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor
    Peter van Kerkhof
    Department of Cell Biology, University Medical Center Utrecht and Institute of Biomembranes, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 282:20475-83. 2007
  9. doi Impact of the exon 3-deleted growth hormone (GH) receptor polymorphism on baseline height and the growth response to recombinant human GH therapy in GH-deficient (GHD) and non-GHD children with short stature: a systematic review and meta-analysis
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 94:3721-30. 2009
  10. doi The exon 3 deleted growth hormone receptor gene is associated with small birth size and early pubertal onset in healthy boys
    Kaspar Sørensen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:2819-26. 2010

Research Grants

  1. Fetal Postnatal Regulation of Expression of the GH Receptor
    Ram K Menon; Fiscal Year: 2010
  2. Cross-talk between growth hormone and inflammation pathways in kidney damage
    Karen T Coschigano; Fiscal Year: 2010
  3. Stuart J Frank; Fiscal Year: 2014
  4. Production &Crystallization of Membrane Protein for 3D Structure
    Lawrence J Delucas; Fiscal Year: 2013
  5. Dan M Cooper; Fiscal Year: 2016
  6. The Somatotropic Axis and Health Aging: A Search for Mechanisms
    Andrzej Bartke; Fiscal Year: 2013
  7. Neurodegeneration in Aging Retarded Mice
    Roger Albin; Fiscal Year: 2009
  8. GROWTH RETARDATION IN CHRONIC RENAL FAILURE
    Robert Mak; Fiscal Year: 2001
  9. MECHANISMS OF ORDERED BINDING OF LACTOGENS AND RECEPTORS
    Charles Brooks; Fiscal Year: 2002
  10. Hormonal signals, genome integrity and longevity
    Jan Vijg; Fiscal Year: 2009

Patents

  1. Methods for predicting therapeutic response to agents acting on the growth hormone receptor

Detail Information

Publications303 found, 100 shown here

  1. ncbi The binding of different biosynthetic and extracted human growth hormones to the growth hormone-binding protein of human serum: a comparative study
    A Aguirre
    Endocrinologia, Inst. Proagro, Sucre, Bolivia
    Horm Metab Res 23:281-4. 1991
    This study of the human growth hormone binding protein (GHBP) was undertaken using several samples of hGH, extractive or recombinant, from different origins...
  2. ncbi Regulation of human growth hormone receptor gene transcription by human growth hormone binding protein
    P E Mullis
    Department of Paediatrics, University Childrens Hospital, Inselspital, Bern, Switzerland
    Mol Cell Endocrinol 131:89-96. 1997
    The hypothesis that growth hormone binding protein (GHBP) has an effect on its own on the regulation of the GH-receptor/GHBP transcription was tested...
  3. ncbi Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate
    Evelien F Gevers
    Department of Pediatrics, Leiden University Medical Center, The Netherlands
    J Bone Miner Res 17:1408-19. 2002
    ..The dual effector theory suggests that GH would act primarily on the "stem cells." However, staining with a GH receptor (GHR) antibody is found in all layers of the growth plate in rabbits and humans...
  4. doi Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes
    Yong Yang
    Chinese Academy of Medical Sciences, Department of Orthopedics, Peking Union Medical College, Beijing, China
    Orthopedics 32:411. 2009
    ..A replicable study is vital for reliability. To determine the relationship of growth hormone receptor and IGF-1 genes with adolescent idiopathic scoliosis, a population-based association study was performed...
  5. ncbi Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1
    L S Argetsinger
    Department of Physiology, University of Michigan Medical School, Ann Arbor 48109 0622, USA
    J Biol Chem 270:14685-92. 1995
    ..The ability of GH receptor (GHR) to transduce the signal for IRS-1 tyrosyl phosphorylation is mediated by the intracellular region of GHR ..
  6. pmc Alternative splicing of exon 3 of the human growth hormone receptor is the result of an unusual genetic polymorphism
    M L Stallings-Mann
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 93:12394-9. 1996
    Two isoforms of the human growth hormone receptor (hGHR), which differ in the presence (hGHRwt) or absence (hGHRd3) of exon 3, are expressed in the placenta...
  7. ncbi Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
    Richard J Brown
    Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia
    Nat Struct Mol Biol 12:814-21. 2005
    Growth hormone is believed to activate the growth hormone receptor (GHR) by dimerizing two identical receptor subunits, leading to activation of JAK2 kinase associated with the cytoplasmic domain...
  8. ncbi The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor
    Peter van Kerkhof
    Department of Cell Biology, University Medical Center Utrecht and Institute of Biomembranes, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 282:20475-83. 2007
    ..We show that the same ligase drives endocytosis and degradation of the growth hormone receptor (GHR) in a ligand-independent fashion...
  9. doi Impact of the exon 3-deleted growth hormone (GH) receptor polymorphism on baseline height and the growth response to recombinant human GH therapy in GH-deficient (GHD) and non-GHD children with short stature: a systematic review and meta-analysis
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 94:3721-30. 2009
    The exon-3 deleted GH receptor (GHR(d3)) polymorphism is associated with an increased growth response to recombinant human GH (rhGH) therapy in some, but not all, studies in GH-deficient (GHD) and non-GHD children with short stature.
  10. doi The exon 3 deleted growth hormone receptor gene is associated with small birth size and early pubertal onset in healthy boys
    Kaspar Sørensen
    Department of Growth and Reproduction, GR 5064, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 95:2819-26. 2010
    The GH/IGF-I axis influences gonadal development and function. Recently, a deletion of exon 3 in the GH receptor gene (GHRd3) has been linked to increased responsiveness to GH.
  11. pmc The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels
    Mattias Vesterlund
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e25358. 2011
    ..GH actions are mediated by the Growth Hormone Receptor; a member of the cytokine receptor super family that signals chiefly through the JAK2/STAT5 pathway...
  12. pmc Human metastatic melanoma cell lines express high levels of growth hormone receptor and respond to GH treatment
    Elahu G Sustarsic
    Edison Biotechnology Institute, 1 Watertower Drive, Athens, OH, United States Department of Biological Sciences, Ohio University, Athens, OH, United States
    Biochem Biophys Res Commun 441:144-50. 2013
    Accumulating evidence implicates the growth hormone receptor (GHR) in carcinogenesis...
  13. pmc Multimeric growth hormone receptor complexes serve as signaling platforms
    Magdalena Sedek
    From the Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Biol Chem 289:65-73. 2014
    ..Phosphorylation and ubiquitylation regulate the GH receptor (GHR) at the cell surface: two ubiquitin ligases (SCF(βTrCP2) and CHIP) determine the GH responsiveness of ..
  14. ncbi Laron dwarfism and mutations of the growth hormone-receptor gene
    S Amselem
    Service de Biochimie and INSERM, C H U Henri MONDOR, Creteil, France
    N Engl J Med 321:989-95. 1989
    ..basis, we used genetic linkage to test whether the disorder results from a defect in the gene for the human GH receptor. Denaturing gradient gel electrophoresis and sequencing of specific GH-receptor-gene fragments allowed us to ..
  15. pmc Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism
    P J Godowski
    Department of Developmental Biology, Genentech, Inc, South San Francisco, CA 94080
    Proc Natl Acad Sci U S A 86:8083-7. 1989
    ..Several lines of evidence suggest that this disease is caused by a defect in the growth hormone receptor. In order to analyze the receptor gene in patients with Laron-type dwarfism and with other growth ..
  16. ncbi Expression of exon 3-retaining and exon 3-excluding isoforms of the human growth hormone-receptor is regulated in an interindividual, rather than a tissue-specific, manner
    R B Wickelgren
    Department of Internal Medicine, Sahlgrenska, Hospital, University of Goteborg, Sweden
    J Clin Endocrinol Metab 80:2154-7. 1995
    ..The human GH receptor (GHR) exists in two known isoforms; in one form exon 3 is present (GHR3+), and in the other, exon 3 is absent (..
  17. ncbi Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution
    J Pantel
    Institut National de la Sante et de la Recherche Medicale, Unité 468, Hopital Henri Mondor, 94010 Creteil Cedex, France
    J Biol Chem 275:18664-9. 2000
    In humans, growth hormone receptor (GHR) transcripts exist in two isoforms differing by the retention (GHRfl) or exclusion (GHRd3) of exon 3, whereas in mice GHRfl is solely expressed...
  18. ncbi Identification of a region critical for proteolysis of the human growth hormone receptor
    Françoise Conte
    Centre de Recherche sur la Croissance CRC, Pavillon Leriche, Hopital Purpan, Place du Dr Baylac, Toulouse Cedex, 31059, France
    Biochem Biophys Res Commun 290:851-7. 2002
    Release of soluble growth hormone binding protein (GHBP) corresponding to the extracellular domain of the GH receptor (GHR) occurs via distinct mechanisms depending on species...
  19. ncbi Growth hormone (GH) pharmacogenetics: influence of GH receptor exon 3 retention or deletion on first-year growth response and final height in patients with severe GH deficiency
    Alexander A L Jorge
    Hospital das Clinicas, Laboratorio de Hormonios, Avenida Dr Eneas de Carvalho Aguiar 155 PAMB, 2 Andar Bloco 6, 05403 900, Sao Paulo, Brazil
    J Clin Endocrinol Metab 91:1076-80. 2006
    ..A polymorphism in GHR gene, the presence or absence of exon 3, has been shown to influence the 1- and 2-yr growth responses to human recombinant GH (hGH) therapy in children without GH deficiency (GHD)...
  20. ncbi Exon 3-deleted/full-length growth hormone receptor polymorphism genotype frequencies in Spanish short small-for-gestational-age (SGA) children and adolescents (n = 247) and in an adult control population (n = 289) show increased fl/fl in short SGA
    Laura Audi
    Department of Pediatrics, Hospital Vall d Hebron, Autonmous University, Barcelona, Spain
    J Clin Endocrinol Metab 91:5038-43. 2006
    A polymorphism in the human GH receptor gene (d3/fl-GHR) resulting in genomic deletion of exon 3 has been associated with the degree of height increase in response to GH therapy.
  21. ncbi An intronic growth hormone receptor mutation causing activation of a pseudoexon is associated with a broad spectrum of growth hormone insensitivity phenotypes
    A David
    Centre for Endocrinology, William Harvey Research Institute, University of London, London EC1M 6BQ, United Kingdom
    J Clin Endocrinol Metab 92:655-9. 2007
    Inherited GH insensitivity (GHI) is usually caused by mutations in the GH receptor (GHR)...
  22. ncbi The presence of the d3-growth hormone receptor polymorphism is negatively associated with fetal growth but positively associated with postnatal growth in healthy subjects
    Rikke Beck Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 92:2758-63. 2007
    A common polymorphism in the GH receptor (GHR) gene has been linked to increased growth response in GH-treated patients. No former study has focused on the association to prenatal growth.
  23. ncbi Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor
    Isabel Uyttendaele
    Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research, Ghent University, Faculty of Medicine and Health Sciences, A Baertsoenkaai 3, B 9000 Ghent, Belgium
    Mol Endocrinol 21:2821-31. 2007
    ..protein-protein interaction trap (MAPPIT), a mammalian two-hybrid method, we mapped the binding sites in the GH receptor for signal transducer and activator of transcription 5 (STAT5) a and b and for the negative regulators of ..
  24. ncbi The d3-growth hormone (GH) receptor polymorphism is associated with increased responsiveness to GH in Turner syndrome and short small-for-gestational-age children
    G Binder
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 91:659-64. 2006
    A protein polymorphism of the GH receptor (GHR) based on the genomic deletion of exon 3 (d3-GHR) has recently been linked to the magnitude of growth response to high-dose recombinant human GH (rhGH) therapy of short children without GH ..
  25. ncbi Structure and expression of the mouse growth hormone receptor/growth hormone binding protein gene
    J G Moffat
    Department of Biology, University of California, Santa Cruz, California 95060, USA
    J Mol Endocrinol 23:33-44. 1999
    The mouse growth hormone receptor/growth hormone-binding protein (GHR/BP) gene produces several distinct mRNA forms through alternative splicing, including mRNAs encoding the membrane-bound growth hormone receptor (GHR) and the soluble ..
  26. doi Growth hormone receptor, insulin-like growth factor (IGF)-1, and IGF-binding protein-2 expression in the reproductive tissues of early postpartum dairy cows
    M L Rhoads
    Division of Animal Sciences, University of Missouri, Columbia 65211, USA
    J Dairy Sci 91:1802-13. 2008
    ..In liver, growth hormone receptor (GHR) and IGF-1 are dynamically regulated by lactation and energy balance...
  27. ncbi Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones
    Soojin Yi
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Mol Biol Evol 19:1083-92. 2002
    ..In contrast, its functional counterpart, the human growth hormone receptor (hGHR), has evolved species specificity so that it responds only to Old World primate GHs...
  28. ncbi The insulin-like growth factor I generation test: resistance to growth hormone with aging and estrogen replacement therapy
    S A Lieberman
    Medical Service, Department of Veterans Affairs Medical Center, Palo Alto, California
    Horm Metab Res 26:229-33. 1994
    ..high-affinity circulating GH-binding protein (GHBP) has the same structure as the extracellular domain of the GH receptor and may reflect the sensitivity to GH in humans...
  29. ncbi Growth hormone-binding protein in patients with anorexia nervosa determined in two assay systems
    A Murata
    Department of Pediatrics, Chiba University School of Medicine, Japan
    Horm Metab Res 24:297-9. 1992
    ..serum GH-binding protein (BP) (GH-BP), which has been shown to be identical to the extracellular domain of GH receptor, and therefore might reflect peripheral GH receptor expression (i.e...
  30. ncbi [Effect of recombinant human growth hormone on growth of human Bel-7402 hepatic carcinoma xenografts in nude mice]
    Jian Ping Liu
    Department of General Surgery, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510120, P R China
    Ai Zheng 25:292-6. 2006
    ..Because most primary hepatic carcinoma could express human growth hormone receptor (GHR), this study was to explore the effects of rhGH on the growth of human Bel-7402 hepatic carcinoma (..
  31. ncbi Generation of epitope-specific antibodies to rat GHBP in the sheep using an interspecies switching strategy involving site-directed mutagenesis of ovine GHBP
    J H Shand
    Hannah Research Institute, Ayr, UK
    Eur J Biochem 266:917-23. 1999
    ..Using site-directed mutagenesis, we altered the two dominant linear epitopes in the ovine growth hormone binding protein to the analogous sequences in rat growth hormone binding protein...
  32. ncbi Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system
    Evert Van Garderen
    Department of Pathology, Utrecht University, Utrecht, The Netherlands
    Mol Cell Endocrinol 197:153-65. 2002
    ..The growth hormone receptor (GHR) is also expressed in normal and tumorous canine mammary tissues and in this concise overview we ..
  33. ncbi Growth hormone binding protein 2001
    G Baumann
    Department of Medicine, Northwestern University Medical School, Chicago, IL, USA
    J Pediatr Endocrinol Metab 14:355-75. 2001
    ..with particular emphasis on the high affinity GHBP, which represents the circulating ectodomain of the growth hormone receptor (GHR)...
  34. pmc The influence of gene-environment interactions on GHR and IGF-1 expression and their association with growth in brook charr, Salvelinus fontinalis (Mitchill)
    Guillaume Côté
    Departement de Biologie, Universite Laval, Quebec, Quebec, Canada
    BMC Genet 8:87. 2007
    ..saltwater), sex and genotypic (low vs. high estimated breeding value EBV) effects on the transcription level of insulin-like growth factor (IGF-1) and growth hormone receptor (GHR) in brook charr (Salvelinus fontinalis).
  35. ncbi Increase of serum growth hormone-binding protein in patients with ossification of the posterior longitudinal ligament of the spine
    S Ikegawa
    Department of Orthopedics, Faculty of Medicine, University of Tokyo, Japan
    Spine (Phila Pa 1976) 18:1757-60. 1993
    Serum growth hormone-binding protein (GHBP) was measured in 26 patients with ossification of the posterior longitudinal ligament of the spine (OPLL) and 19 age-matched controls...
  36. ncbi Caveolar and lipid raft localization of the growth hormone receptor and its signaling elements: impact on growth hormone signaling
    Ning Yang
    Department of Cell Biology, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    J Biol Chem 279:20898-905. 2004
    The growth hormone receptor (GHR) is a cell surface receptor that mediates the somatogenic and metabolic effects of the growth hormone (GH)...
  37. pmc Expression of growth hormone receptor and its mRNA in hepatic cirrhosis
    Hong Tao Wang
    Department of Hepato biliary Surgery, Sun Yat Sen Memorial Hospital, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, Guangdong Province, China
    World J Gastroenterol 9:765-70. 2003
    To investigate the expression of growth hormone receptor (GHR) and mRNA of GHR in cirrhotic livers of rats with the intension to find the basis for application of recombinant human growth hormone (rhGH) to patients with liver cirrhosis.
  38. ncbi Impact of growth hormone resistance on female reproductive function: new insights from growth hormone receptor knockout mice
    Denise Zaczek
    Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901 6512, USA
    Biol Reprod 67:1115-24. 2002
    We examined multiple aspects of reproductive function in growth hormone receptor gene knockout (GHR-KO) and normal mice to clarify the role of growth hormone in female reproduction...
  39. ncbi [Expression of growth hormone receptor in hepatocellular carcinoma and its significance]
    Jian Ping Liu
    Department of General Surgery, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, 510120, P R China
    Ai Zheng 22:298-301. 2003
    ..rhGH cannot work except that it combines to its own receptor growth hormone receptor (GHR)...
  40. ncbi Differential regulation of membrane associated-growth hormone binding protein (MA-GHBP) and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver
    L Gonzalez
    Instituto de Quimica y Fisicoquimica Biologicas, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, Buenos Aires, Argentina
    Growth Horm IGF Res 17:104-12. 2007
    ..humans and rabbits and alternative processing of the GHR transcript in rodents generates circulating growth hormone binding protein (GHBP)...
  41. ncbi Characterization of the short isoform of the growth hormone receptor synthesized by rat adipocytes
    G P Frick
    Department of Physiology, University of Massachusetts Medical School, Worcester 01655
    Endocrinology 131:3083-90. 1992
    Two mRNA transcripts that are believed to be alternately spliced products of the GH receptor gene have been reported in a variety of rat tissues. The smaller (1...
  42. ncbi Cloning and characterization of chicken growth hormone binding protein (cGHBP)
    J S Lau
    Department of Zoology, 5N 12, Kadoorie Biological Sciences Building, The University of Hong Kong, Pokfulam Road, Hong Kong, HKSAR, China
    Domest Anim Endocrinol 33:107-21. 2007
    ..GH also binds to the growth hormone binding protein (GHBP) which is the soluble form of GHR extracellular domain existing in circulation...
  43. ncbi Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass meri
    E L Sherman
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2P5, Canada
    J Anim Sci 86:1-16. 2008
    ..In the current study, SNP in the bovine neuropeptide Y (NPY), growth hormone receptor (GHR), ghrelin (GHRL), uncoupling proteins 2 and 3 (UCP2 and UCP3), IGF2, corticotrophin-releasing ..
  44. doi Hepatic gene expression in multiparous Holstein cows treated with bovine somatotropin and fed n-3 fatty acids in early lactation
    M Carriquiry
    Department of Animal Science, University of Minnesota, St Paul 55108 6118, USA
    J Dairy Sci 92:4889-900. 2009
    ..Liver biopsies were collected on -12, 10, 24, and 136 DIM for gene expression analysis. Growth hormone receptor (GHR), insulin-like growth factor-I (IGF-I), IGF-binding protein-3 (IGFBP3), hepatic nuclear factor ..
  45. ncbi Studies of gene expression in liver of insulin-like growth factor (IGF)-I, IGF binding protein-3 and growth hormone (GH) receptor/GH binding protein in rats treated neonatally with monosodium glutamate
    A Kubota
    Department of Paediatrics, Hamamatsu University School of Medicine, Japan
    Horm Metab Res 26:497-503. 1994
    ..growth factor (IGF)-I, IGF binding protein (IGFBP)-3 and growth hormone (GH) receptor (GHR)/GH binding protein (GHBP) in liver of rats treated neonatally with monosodium glutamate (MSG)...
  46. ncbi Determinants of growth hormone receptor down-regulation
    Luqin Deng
    Department of Cell Biology, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 21:1537-51. 2007
    b>GH receptor (GHR) is a cytokine receptor family member that responds to GH by activation of the receptor-associated tyrosine kinase, JAK2 (Janus family of tyrosine kinase 2)...
  47. ncbi Effects of food deprivation on expression of growth hormone receptor and proximate composition in liver of black seabream Acanthopagrus schlegeli
    L Deng
    College of Life Science, Shenzhen University, Shenzhen 518060, PR China
    Comp Biochem Physiol B Biochem Mol Biol 137:421-32. 2004
    The effects of food deprivation on the hepatic level growth hormone receptor (GHR) were investigated in black seabream (Acanthopagrus schlegeli) both at the protein level (by radioreceptor assay) and at the mRNA level (by ribonuclease ..
  48. ncbi Involvement of hepatocyte nuclear factor-4 in the expression of the growth hormone receptor 1A messenger ribonucleic acid in bovine liver
    H Jiang
    Animal Sciences Research Center, Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Mol Endocrinol 15:1023-34. 2001
    The GH receptor 1A mRNA (GHR 1A mRNA) is one of the major GHR mRNA variants that differ in the 5'-untranslated region. The GHR 1A mRNA is unique because it is exclusively expressed in liver...
  49. pmc Divergent evolution in the cytoplasmic domains of PRLR and GHR genes in Artiodactyla
    Terhi Iso-Touru
    Biotechnology and Food Research, MTT Agrifood Research Finland, Jokioinen, Finland
    BMC Evol Biol 9:172. 2009
    Prolactin receptor (PRLR) and growth hormone receptor (GHR) belong to the large superfamily of class 1 cytokine receptors...
  50. ncbi Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse
    S J Hauck
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901 6512, USA
    Exp Biol Med (Maywood) 226:552-8. 2001
    ..Reductions in these parameters may be important to the underlying mechanisms of delayed aging in these animals...
  51. ncbi Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and hepatocyte nuclear factor 4gamma (HNF-4gamma) and HNF-4alpha regulate the bovine growth hormone receptor 1A promoter through a common DNA element
    Q Xu
    Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    J Mol Endocrinol 32:947-61. 2004
    The growth hormone receptor (GHR) 1A promoter is responsible for transcription of the liver-specific GHR mRNA variant 1A in several mammalian species...
  52. ncbi Evidence supporting dual, IGF-I-independent and IGF-I-dependent, roles for GH in promoting longitudinal bone growth
    J Wang
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA
    J Endocrinol 180:247-55. 2004
    ..To test this hypothesis, we compared long bone growth in mice with targeted deletions of Igf1 vs growth hormone receptor (Ghr)...
  53. pmc Lipopolysaccharide (LPS) directly suppresses growth hormone receptor (GHR) expression through MyD88-dependent and -independent Toll-like receptor-4/MD2 complex signaling pathways
    Prapai Dejkhamron
    Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
    Mol Cell Endocrinol 274:35-42. 2007
    ..in the intact animal the major surface component of the bacterial cell wall, lipopolysaccharide (LPS), inhibits GH receptor (GHR) gene expression...
  54. pmc Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects
    Louise Moller
    Medical Department M, Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Aarhus Sygehus, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 94:4524-32. 2009
    ..These models may not adequately reflect the selective effects of GH, and GH receptor (GHR) blockade offers a new model to define the metabolic role of GH.
  55. ncbi Plasma leptin in depressed patients and healthy controls
    M Deuschle
    Max Planck Institute of Psychiatry, Clinical Institute, , Germany
    Horm Metab Res 28:714-7. 1996
    ..suspected to be related to leptin, we also studied cortisol, insulin, growth hormone (GH) and GH-binding protein (GHBP). We found that leptin plasma concentrations did not differ between depressed patients and healthy controls...
  56. ncbi Variants of the 5'-untranslated region of the bovine growth hormone receptor mRNA: isolation, expression and effects on translational efficiency
    H Jiang
    Department of Animal Sciences, 164 Animal Science Research Center, University of Missouri, 65211 5300, Columbia MO, USA
    Gene 265:45-53. 2001
    The growth hormone receptor (GHR) gene in cattle is expressed as multiple GHR mRNA variants that differ in the 5'-untranslated region (5'-UTR). Three GHR mRNA 5'-UTR variants (named 1A, 1B, and 1C) were isolated in previous studies...
  57. ncbi Expression of growth hormone receptor 1A mRNA is decreased in dairy cows but not in beef cows at parturition
    H Jiang
    Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg 24061, USA
    J Dairy Sci 88:1370-7. 2005
    ....
  58. ncbi Cloning of Atlantic halibut growth hormone receptor genes and quantitative gene expression during metamorphosis
    Jon Hildahl
    Fish Endocrinology Laboratory, Department of Zoology Zoophysiology, Goteborg University, Box 436, S 40530 Göteborg, Sweden
    Gen Comp Endocrinol 151:143-52. 2007
    ..The cDNA of the full-length GH receptor (hhGHR) was cloned from adult liver and characterized...
  59. ncbi CIDE-A gene expression is decreased in white adipose tissue of growth hormone receptor/binding protein gene disrupted mice and with high-fat feeding of normal mice
    Bruce Kelder
    Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA
    Growth Horm IGF Res 17:346-51. 2007
    ..WAT) results in decreased body fat in giant GH transgenic mice and increased subcutaneous fat in dwarf growth hormone receptor/binding protein gene-disrupted mice (GHR -/-)...
  60. ncbi Regulation of human growth hormone receptor gene transcription by triiodothyronine (T3)
    P E Mullis
    Department of Paediatrics, Inselspital, Bern, Switzerland
    Mol Cell Endocrinol 147:17-25. 1999
    ..hormone (GH) may have some direct or indirect effect on the regulation of GH-receptor/GH-binding protein (GHR/GHBP) gene transcription was tested. Different concentrations of T3 (0, 0...
  61. ncbi Growth hormone receptor interaction with Jak proteins differs between tissues
    G Hellgren
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    J Interferon Cytokine Res 21:75-83. 2001
    ..The growth hormone receptor (GHR) is believed to interact predominantly with Jak2, but studies on cell lines have shown that it may ..
  62. ncbi Reduced serum insulin-like growth factor (IGF) I is associated with reduced liver IGF-I mRNA and liver growth hormone receptor mRNA in food-deprived cattle
    Ying Wang
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA
    J Nutr 133:2555-60. 2003
    ..mechanism by determining the effects of food deprivation on the levels of total IGF-I mRNA and total growth hormone receptor (GHR) mRNA, as well as the levels of individual IGF-I mRNA variants and GHR mRNA variants in the liver of ..
  63. ncbi Janus kinase 2 influences growth hormone receptor metalloproteolysis
    Kimberly Loesch
    Department of Cell Biology, University of Alabama, Birmingham, Alabama 35294 0012, USA
    Endocrinology 147:2839-49. 2006
    GH signals through the GH receptor (GHR), a cytokine receptor superfamily member that couples to the cytoplasmic tyrosine kinase, Janus kinase 2 (JAK2)...
  64. ncbi Uterine and hepatic gene expression in relation to days postpartum, estrus, and pregnancy in postpartum dairy cows
    M L Rhoads
    Division of Animal Sciences, University of Missouri, Columbia 65211, USA
    J Dairy Sci 91:140-50. 2008
    The somatotropic axis consisting of growth hormone, the growth hormone receptor (GHR) insulin-like growth factor (IGF)-I, and IGF binding proteins changes with the stage of lactation and nutrition of the cow and may be 1 mechanism ..
  65. doi Effects of a lone star tick (Amblyomma americanum) burden on performance and metabolic indicators in growing beef steers
    D R Tolleson
    The University of Arizona, V Bar V Ranch, School of Natural Resources and the Environment, 2657 S Village Dr, Cottonwood, AZ 86326 5875, United States
    Vet Parasitol 173:99-106. 2010
    ..1) glucose concentrations. Tick treatment did not significantly (P<0.1) affect growth hormone receptor (GHR) mRNA in liver, but liver tissue from treated animals had numerically lower GHR mRNA than did tissue ..
  66. ncbi Identification of novel sites in the ovine growth hormone receptor involved in binding hormone and conferring species specificity
    G J Allan
    Hannah Research Institute, Ayr, Scotland, UK
    Eur J Biochem 261:555-62. 1999
    Using site-directed mutagenesis we mutated the extracellular domain of the ovine growth hormone receptor (oGHR) to the corresponding amino acids in the rat GHR at two different sites: site A is between Thr28 and Leu34 and represents a ..
  67. ncbi Expression and molecular characterization of the growth hormone receptor in canine mammary tissue and mammary tumors
    E van Garderen
    Department of Pathology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
    Endocrinology 140:5907-14. 1999
    ..In the present report, the characteristics of the GH receptor (GHR) are studied in these tissues...
  68. ncbi Growth hormone receptor expression in human colorectal cancer
    Xiaodong Yang
    Medical College, Nanjing University, Nanjing, Jiangsu 210093, China
    Dig Dis Sci 49:1493-8. 2004
    The purpose of this study was to determine whether human colorectal cancer (CRC) expresses growth hormone receptor (GHR) and whether growth hormone plays an important role in the development and progression of human CRC...
  69. ncbi Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice
    Katie Robertson
    Fraser Laboratories for Diabetic Research, Department of Medicine, McGill University Health Center, Montreal, QC, Canada
    Am J Physiol Endocrinol Metab 291:E491-8. 2006
    ..These data demonstrate that GH signaling is not required for compensatory islet growth. Thus, in both muscle insulin responsiveness and islet growth compensation, normal levels of GH signals do not seem to play a dominant role...
  70. ncbi [Significance of the changes of growth hormone receptor mRNA in liver after cardiopulmonary bypass in a rat model]
    Yong An
    Cardiovascular Surgery Center of People s Liberation Army, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
    Zhonghua Wai Ke Za Zhi 45:1485-7. 2007
    To study the significance of the changes of growth hormone receptor mRNA (GHR mRNA) in liver after cardiopulmonary bypass (CPB) in a rat model.
  71. doi The extracellular domain of the growth hormone receptor interacts with coactivator activator to promote cell proliferation
    Becky L Conway-Campbell
    Institute for Molecular Bioscience, University of Queensland, St Lucia 4072, Australia
    Mol Endocrinol 22:2190-202. 2008
    The presence of GH receptor (GHR) in the cell nucleus correlates with cell division, and targeting the GHR to the nucleus results in constitutive proliferation and transformation because of increased sensitivity to autocrine GH...
  72. ncbi Stature in Ecuadorians heterozygous for growth hormone receptor gene E180 splice mutation does not differ from that of homozygous normal relatives
    A L Rosenbloom
    Department of Pediatrics, University of Florida College of Medicine, Gainesville 32608, USA
    J Clin Endocrinol Metab 83:2373-5. 1998
    Heterozygosity for certain mutations of the GH receptor (GHR) gene has been proposed as the cause of partial resistance to GH, and there has been a recent demonstration of a dominant-negative effect of such a mutation in a mother and ..
  73. ncbi Puberty is delayed in male growth hormone receptor gene-disrupted mice
    David E Keene
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901 6512, USA
    J Androl 23:661-8. 2002
    ..These results suggest that the absence of IGF-I secretion delays the normal course of sexual maturation in male GHR-KO mice, indicating that IGF-I plays an important role in the initiation of puberty in male mice...
  74. ncbi Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling
    Kai He
    Department of Medicine, University of Alabama, Birmingham, Alabama 35294 0012, USA
    Mol Endocrinol 17:2211-27. 2003
    GH signaling depends on functional interaction of the GH receptor (GHR) and the cytoplasmic tyrosine kinase, Janus kinase 2 (JAK2), which possesses a C-terminal kinase domain, a catalytically inactive pseudokinase domain just N-terminal ..
  75. pmc The role of the bovine growth hormone receptor and prolactin receptor genes in milk, fat and protein production in Finnish Ayrshire dairy cattle
    Sirja Viitala
    MTT Agrifood Research Finland, Biotechnology and Food Research, Jokioinen, Finland
    Genetics 173:2151-64. 2006
    ..the QTL effect on chromosome 20 in Finnish Ayrshire can be explained by variation in two distinct genes, growth hormone receptor (GHR) and prolactin receptor (PRLR)...
  76. ncbi Expression of somatotropin receptor messenger ribonucleic acid in bovine tissues
    M C Lucy
    Department of Animal Sciences, University of Missouri, Columbia 65211, USA
    J Dairy Sci 81:1889-95. 1998
    The somatotropin receptor mRNA is controlled by at least two different gene promoters that generate two variants with different exon 1 sequences (1A and 1B)...
  77. ncbi Expression of two variants of growth hormone receptor messenger ribonucleic acid in porcine liver
    J Liu
    Department of Animal Science, University of Missouri, Columbia 65211, USA
    J Anim Sci 78:306-17. 2000
    Transcription of GH receptor (GHR) mRNA is initiated from multiple promoters. Most GHR mRNA arise from GHR Promoter 1 (GHR P1) and GHR P2, which transcribe GHR 1A and GHR 1B mRNA, respectively...
  78. ncbi Growth hormone receptor deficiency in mice results in reduced systolic blood pressure and plasma renin, increased aortic eNOS expression, and altered cardiovascular structure and function
    E Egecioglu
    Departments of Physiology, Sahlgrenska Academy, Goteborg University, Gothenberg, Sweden
    Am J Physiol Endocrinol Metab 292:E1418-25. 2007
    To study the role of the growth hormone receptor (GHR) in the development of cardiovascular structure and function, female GHR gene-disrupted or knockout (KO) and wild-type (WT) mice at age 18 wk were used...
  79. ncbi Growth hormone stimulates hepatic expression of bovine growth hormone receptor messenger ribonucleic acid through signal transducer and activator of transcription 5 activation of a major growth hormone receptor gene promoter
    Honglin Jiang
    Department of Animal and Poultry Sciences, Large Animal Clinical Sciences, 3130 Litton Reaves Hall, Virginia Tech, Blacksburg, Virginia 24061 0306, USA
    Endocrinology 148:3307-15. 2007
    The objective of this study was to determine whether and how GH regulates hepatic expression of GH receptor (GHR) mRNA in cattle...
  80. doi A novel Y332C missense mutation in the intracellular domain of the human growth hormone receptor does not alter STAT5b signaling: redundancy of GHR intracellular tyrosines involved in STAT5b signaling
    Michael A Derr
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Horm Res Paediatr 75:187-99. 2011
    The growth hormone receptor (GHR), upon binding with GH, induces JAK2-mediated phosphorylation of GHR intracellular tyrosines, which then recruit STAT5b...
  81. doi The growth hormone receptor (GHR) exon 3 polymorphism and its correlation with metabolic profiles in obese Chinese children
    Lingling Gao
    Children s Hospital of Fudan University, Pediatric Endocrinology and Inborn Metabolic Diseases, Shanghai, China
    Pediatr Diabetes 12:429-34. 2011
    We investigated the correlation between the growth hormone receptor (GHR) exon 3 polymorphism and the metabolic profiles of Chinese children with obesity.
  82. ncbi Evaluation of the somatogenic activity of bovine placental lactogen with cell lines transfected with the bovine somatotropin receptor
    W C Warren
    Agricultural Sector, Monsanto Company, St Louis, MO 63198, USA
    Life Sci 65:2755-67. 1999
    ..in vivo even though binding results clearly indicate bPL does not cause homodimerization of the bovine somatotropin receptor (bST-R)...
  83. doi Characterization of the GHR gene genetic variation in Chinese indigenous goat breeds
    W L Bai
    College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110161, China
    Mol Biol Rep 38:471-9. 2011
    The aim of the present work was to investigate single nucleotide polymorphism (SNP) of growth hormone receptor (GHR) gene exon 10, characterize the genetic variation in three Chinese indigenous goat breeds, and search for its potential ..
  84. ncbi Extracellular domain of prolactin receptor from bovine mammary gland: expression in Escherichia coli, purification and characterization of its interaction with lactogenic hormones
    A Tchelet
    Department of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel
    J Endocrinol 144:393-403. 1995
    ....
  85. ncbi One class of growth hormone (GH) receptor and binding protein messenger ribonucleic acid in rat liver, GHR1, is sexually dimorphic and regulated by GH
    W R Baumbach
    Agricultural Research Division, American Cyanamid Company, Princeton, New Jersey 08543
    Endocrinology 136:749-60. 1995
    In the rat, alternatively spliced messenger RNA (mRNA) species encode GH receptor (GHR) and GH-binding protein (GHBP)...
  86. pmc A single arginine residue determines species specificity of the human growth hormone receptor
    S C Souza
    Faculdade de Medicina de Ribeirao Preto Universidade de Sao Paulo, Brazil
    Proc Natl Acad Sci U S A 92:959-63. 1995
    ..that changed Leu43 to Arg were introduced into the cDNAs encoding the bovine (b) GHR or the rat GH binding protein (GHBP) and these mutants or their wild-type (WT) counterparts were expressed in mouse L cells...
  87. ncbi The structure and regulation of expression of the mouse growth hormone receptor and binding protein
    F Talamantes
    Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz 95064
    Proc Soc Exp Biol Med 206:254-6. 1994
    The mouse growth hormone receptor (mGHR) and the mouse growth hormone-binding protein (mGHBP) are products of a single gene which are generated by alternative splicing...
  88. ncbi Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase
    W Yi
    Department of Medicine, University of Alabama, Birmingham, USA
    Mol Endocrinol 10:1425-43. 1996
    GH-induced activation of JAK2, a GH receptor (GHR)-associated tyrosine kinase, leads to tyrosine phosphorylation and activation of STATs (signal transducers and activators of transcription) 1, 3, and 5...
  89. ncbi Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced diabetic animals: effect of a growth hormone receptor antagonist
    Ana C P Thirone
    Department of Internal Medicine, FCM, State University of Campinas, 13080 970 Campinas, Sao Paulo, Brazil
    Diabetes 51:2270-81. 2002
    ..The implicated effect of GH in diabetic end-stage organ damage may be mediated by growth hormone receptor (GHR) or postreceptor events in GH signal transduction...
  90. ncbi Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins
    Liora Ben-Yair
    Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, The Hebrew University, Rehovot 76100, Israel
    Protein Expr Purif 25:456-64. 2002
    ..Cells transfected with eight of these tagged constructs expressed the fluorescent proteins in both the nucleus and cytosol; the tagged SOCS2 was localized mostly in the latter compartment...
  91. ncbi Growth hormone in the nervous system: autocrine or paracrine roles in retinal function?
    S Harvey
    Perinatal Research Center, 7 41 Medical Sciences Building, University of Alberta, Edmonton, AB T6G 2H7, Canada
    Can J Physiol Pharmacol 81:371-84. 2003
    ..This immunoreactivity is also associated with the presence of GH receptor (GHR) immunoreactivity and GHR mRNA in ocular tissues of chick embryos...
  92. ncbi Levels of plasma insulin-like growth factor I (IGF I), IGF II, IGF binding proteins, type 1 IGF receptor and growth hormone binding protein in community-dwelling elderly subjects with no malnutrition and no inflammation
    A Raynaud-Simon
    Unité de Nutrition Gériatrique, hôpital Charles Foix AP HP, F 94205 Ivry sur Seine, France
    J Nutr Health Aging 7:267-73. 2003
    ..Concentrations of IGF I, IGF II and IGFBP3 significantly decreased, and those of GHBP slightly increased with age from 20 to 92 years (n=327 r=-0.64 p<0.0001; n=45 r=-0.44 p<0.003; n=91 r=-0...
  93. ncbi Analysis of the human growth hormone receptor and IGF-I coding sequences in children with growth disorders
    Aleksandra Obrepalska-Steplowska
    Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland
    J Pediatr Endocrinol Metab 16:819-25. 2003
    ..This suggests that the growth disorders in this group of children might be due to a defect in a DNA region regulating expression of the GHR and IGF1 genes or genes involved in their regulation...
  94. ncbi Genetic analysis of short stature
    S G Kant
    CHCG Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Horm Res 60:157-65. 2003
    ..Important options are UPD7 and the FGFR3, SHOX, GH1 and GHR genes. Furthermore, analysis of the IGF and IGF1R genes should be considered. We propose a flow chart for molecular analysis in short stature...
  95. ncbi Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice
    Yubin Guo
    Fraser Laboratories, Room M3 15, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Endocrinology 146:2602-9. 2005
    ..b>GH receptor gene deficiency (GHR(-/-)) caused diminished pancreatic islet cell mass and serum insulin level and elevated ..
  96. pmc The evolutionary radiation of Arvicolinae rodents (voles and lemmings): relative contribution of nuclear and mitochondrial DNA phylogenies
    Thomas Galewski
    Laboratoire de Paléontologie, Phylogénie et Paléobiologie CC064, Institut des Sciences de l Evolution UMR 5554 CNRS, Universite Montpellier II, France
    BMC Evol Biol 6:80. 2006
    ..Here, we compare the relative contribution of a nuclear marker--the exon 10 of the growth hormone receptor (GHR) gene--to the one of the mitochondrial CYB for inferring phylogenetic relationships among the major ..
  97. ncbi Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken
    X Wang
    Department of Animal and Food Sciences, University of Delaware, Newark, DE 19717, USA
    Cytogenet Genome Res 117:174-88. 2007
    ..In conclusion, this study provides the first global analysis of endocrine (T3 and GH) regulation of hepatic gene transcription in the chicken...
  98. pmc Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging
    William R Swindell
    Department of Pathology, University of Michigan, 3118 BSRB, Ann Arbor, MI, USA
    BMC Genomics 8:353. 2007
    ..Points of overlap with the effects of calorie restriction (CR), CR mimetic compounds, low fat diets, gender dimorphism and aging were also examined...
  99. doi Influence of the d3-growth hormone (GH) receptor isoform on short-term and long-term treatment response to GH replacement in GH-deficient adults
    Agatha A van der Klaauw
    Department of Endocrinology and Metabolic Diseases C4 R, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Endocrinol Metab 93:2828-34. 2008
    ..In children, a common polymorphism of the GH receptor (exon-3 deletion, d3GHR) increases the response to rhGH replacement...
  100. pmc The genome response to artificial selection: a case study in dairy cattle
    Laurence Flori
    INRA, UMR de Génétique Animale et Biologie Intégrative, Jouy en Josas, France
    PLoS ONE 4:e6595. 2009
    ..Altogether, these observations shed light on the antagonism, at the genome level, between milk production and reproduction traits in highly producing dairy cows...
  101. doi Further evidence for an association between mandibular height and the growth hormone receptor gene in a Japanese population
    Yoko Tomoyasu
    Department of Orthodontics, School of Dentistry, Showa University, Tokyo, Japan
    Am J Orthod Dentofacial Orthop 136:536-41. 2009
    ..It has recently been reported that single nucleotide polymorphisms (SNPs) in the growth hormone receptor gene (GHR) are associated with mandibular height...

Research Grants70

  1. Fetal Postnatal Regulation of Expression of the GH Receptor
    Ram K Menon; Fiscal Year: 2010
    Expression and function of the growth hormone receptor (GHR) is essential for the action of pituitary growth hormone (GH)...
  2. Cross-talk between growth hormone and inflammation pathways in kidney damage
    Karen T Coschigano; Fiscal Year: 2010
    ..To test the first hypothesis, we will induce diabetes in growth hormone receptor/binding protein knock-out (GHR/BP KO) mice, which lack GH signaling, and their non-transgenic (NT) ..
  3. Stuart J Frank; Fiscal Year: 2014
    ..These studies of the growth hormone receptor investigate the determinants of growth hormone sensitivity at the cellular level...
  4. Production &Crystallization of Membrane Protein for 3D Structure
    Lawrence J Delucas; Fiscal Year: 2013
    ..protein, CFTR), two GPCRs (chemokine receptor-1, CCR1 and sphingosine- 1 phosphate receptor, S1P) and growth hormone receptor, GHR...
  5. Dan M Cooper; Fiscal Year: 2016
    ..intervention on the balance between circulating anabolic mediators (insulin-like growth factor-I and growth hormone binding protein) and inflammation-associated cytokines (interleukin-6, and interleukin-1 receptor antagonist), which ..
  6. The Somatotropic Axis and Health Aging: A Search for Mechanisms
    Andrzej Bartke; Fiscal Year: 2013
    ..Project 2 will produce novel animals lacking the GHR/GHBP gene only in the liver, white adipose tissue or muscle...
  7. Neurodegeneration in Aging Retarded Mice
    Roger Albin; Fiscal Year: 2009
    ..responsible for a moderately aggressive phenotype and 2 copies of a null mutation mutation at the Growth Hormone receptor (GHR) locus...
  8. GROWTH RETARDATION IN CHRONIC RENAL FAILURE
    Robert Mak; Fiscal Year: 2001
    ..Two specific molecular defects in the GH-IGF-I axis have been identified in CRF chondrocytes. Growth hormone receptor(GHR) mRNA (Northern blot) and protein (immunoblot) are both decreased in CRF chondrocytes and may account ..
  9. MECHANISMS OF ORDERED BINDING OF LACTOGENS AND RECEPTORS
    Charles Brooks; Fiscal Year: 2002
    ..Current information suggests lactogens may be similar to hGH and the somatotropin receptor where binding is an ordered process...
  10. Hormonal signals, genome integrity and longevity
    Jan Vijg; Fiscal Year: 2009
    ..we will compare the lacZ mutation accumulation pattern in cells and tissues of these mice with that in Growth Hormone Receptor (GHR)- and IGF-1 receptor (IGF-1 R)- defective mice...
  11. FETAL/POSTNATAL REGULATION OF GH RECEPTOR EXPRESSION
    Ram Menon; Fiscal Year: 2000
    ..At the cellular level GH elicits its actions by initially binding to a cell surface protein termed the growth hormone receptor (GHR)...
  12. GROWTH HORMONE RECEPTORS AND ACTIONS
    Christin Carter Su; Fiscal Year: 2000
    ..applicant's abstract): The main purpose of these studies will be to analyze in detail the regions of the growth hormone receptor (GHR) and the JAK2 kinase that are activated in response to growth hormone binding, to identify signaling ..
  13. GROWTH HORMONE RECEPTOR SIGNAL TRANSDUCTION
    Gerhard Baumann; Fiscal Year: 1992
    ..2) The intracellular domain of the GH receptor will be expressed in both monomeric and dimeric form. It will then be used as an affinity reagent to...
  14. TYROSINE PHOSPHORYLATION AND GROWTH HORMONE SIGNALING
    Stuart J Frank; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Growth hormone (GH) initiates biological actions by interacting with GH receptor (GHR), which activates the cytoplasmic tyrosine kinase, JAK2, and signaling molecules including signal transducer and ..
  15. Thomas L Clemens; Fiscal Year: 2014
    ..These aims employ complementary genetic mouse models and their myoblasts to identify the mechanisms and of action of GH in skeletal muscle and distinguish effects of GH from those mediated by IGF-1. ..
  16. Tyrosine Phosphyorylation and Growth Hormone Signaling
    STUART FRANK; Fiscal Year: 2005
    ..These studies will significantly expand knowledge of GH and cytokine signaling and of biologicallyrelevant crosstalk between cytokine and growth factor signaling systems. ..
  17. Stuart J Frank; Fiscal Year: 2016
    ....
  18. Growth Hormone Regulation of SH2-B1
    Christin Carter Su; Fiscal Year: 2009
    ..abstract_text> ..
  19. GROWTH HORMONE RECEPTORS AND ACTIONS
    Christin Carter Su; Fiscal Year: 2010
    ..was the identification of the tyrosine (Tyr) kinase JAK2 as a receptor-associated signaling molecule for the GH receptor (GHR)...
  20. THOMAS STERLING SCANLAN; Fiscal Year: 2014
    ..Circulating T1AM is tightly bound to a unique serum binding protein which we have recently identified as apoB-100, the major protein component of low density lipoprotein (LDL)..
  21. Thyroid Hormone Action
    Thomas Scanlan; Fiscal Year: 2009
    ..Circulating T1AM is tightly bound to a unique serum binding protein and total T1AM levels are on par with those of total T4...
  22. GROWTH HORMONE IN PITUITARY AND TESTICULAR FUNCTION
    Varadaraj Chandrashekar; Fiscal Year: 2000
    ..To address this issue, pituitary and testicular functions will be evaluated in GH receptor knockout (GHR-KO mice; a model for Laron syndrom) and transgenic mice expressing the human GHRH gene (GHRH mice;..
  23. MICHAL MATEUSZ MASTERNAK; Fiscal Year: 2014
    ..Aim 3: Determine the function of visceral fat developed in the absence of GH action on insulin signaling in vivo by transplanting visceral fat from GHRKO into normal mice. ..
  24. Cytokine Regulation of Liver Growth Hormone Signaling
    Lee Denson; Fiscal Year: 2004
    ..an acquired growth hormone (GH) resistance, in which GH secretion is normal, but hepatic expression of the GH receptor (GHR) and synthesis of anabolic target genes including IGF-I is reduced...
  25. MECHANISMS OF GH RESISTANCE IN SEPSIS
    Robert Cooney; Fiscal Year: 2001
    ..GH insensitivity may be caused by alterations in GH bioavailability, quantitative or qualitative defects in the GH receptor (GHR), postreceptor defects in GHR signal transduction, or by altered expression of GH responsive genes...
  26. Identification of JAK2 Binding Proteins
    Todd Davies; Fiscal Year: 2005
    DESCRIPTION (provided by candidate): The binding of growth hormone (GH) to GH receptor (GHR) activates JAK2, which phosphorylates itself, GHR, and induces the activation of signaling pathways...
  27. Cytokine Regulation of Growth Hormone Signaling
    LEE ARMISTEAD DENSON; Fiscal Year: 2010
    ..We hypothesize that down regulation of the GH receptor (GHR) by TNF inhibits GH signaling in colitis...
  28. Aging:Mechanisms & Prevention:34th Annual Meeting of AGE
    Andrzej Bartke; Fiscal Year: 2005
    ..Financial assistance will be provided to those in training to encourage their participation in the meeting. ..
  29. 7th Intl Symposium-Neurobiology/Neuroendocrinology/Aging
    Andrzej Bartke; Fiscal Year: 2004
    ..We are also seeking support for the presenters of the Special Lecture and the Keynote Lecture who will be traveling to Bregenz from the United States. ..
  30. Eighth & Ninth International Symposia on Neurobiology & Neuroendocrinology Aging
    Andrzej Bartke; Fiscal Year: 2007
    ..We are also seeking partial support for the expenses of invited speakers from the United States. [unreadable] [unreadable] [unreadable]..
  31. Creation and characterization of GH binding protein gene disrupted mice
    John Kopchick; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): To date, the biological role of growth hormone binding protein (GHBP) remains largely unknown...
  32. The impact of growth hormone on adipose tissue
    Darlene Berryman; Fiscal Year: 2006
    ..Visits to the laboratories of the cosponsors will occur as needed. As a model system, I will study a GH receptor/binding protein gene-disrupted (GHR -/-) mouse line previously generated in the Kopchick laboratory...
  33. Role of KAP expression in the diabetic kidney
    Karen Coschigano; Fiscal Year: 2002
    ..Acceptance of the hypothesis could lead to the development of KAP as a therapeutic drug for the prevention of kidney damage. ..
  34. Growth hormone regulation of IGF-I gene expression
    Honglin Jiang; Fiscal Year: 2006
    ..The results of this research should provide a basis for further elucidating the molecular mechanism by which GH regulates IGF-I gene expression. ..
  35. MOLECULAR COEVOLUTION OF GROWTH HORMONE AND ITS RECEPTOR
    Wen Hsiung Li; Fiscal Year: 2002
    ..3. Express GH and GH binding protein (GHBP) cDNAs from various species. 4...
  36. ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*
    David Clemmons; Fiscal Year: 2005
    ....
  37. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David Clemmons; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  38. DIETARY & GENETIC CONTROL OF ROS DAMAGE TO THE LENS
    Norman S Wolf; Fiscal Year: 2010
    ..These will aid in the search for initiating events and the mechanisms leading up to the cataract formation. ..
  39. NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONES
    RHONDA KINEMAN; Fiscal Year: 2006
    ..The current application centers on the interrelationship between changes in metabolic function and the GH axis. ..
  40. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  41. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  42. WILD DERIVED MOUSE STOCKS--NEW MODELS FOR AGING RESEARCH
    Richard Miller; Fiscal Year: 2004
    ....
  43. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  44. Cis-regulatory motif variants and evolution of gene regulation in yeasts
    Wen Hsiung Li; Fiscal Year: 2009
    ....
  45. Genetics of Schizophrenia in Oceanic Palau.
    Marina Myles Worsley; Fiscal Year: 2009
    ..Molecular and fine-mapping studies will identify risk loci. We believe this study is unique among studies of Scz genetics for its population, sample, research team and the novelty of hypotheses and approach. ..
  46. HUMAN DNA POLYMORPHISM AND EVOLUTION
    Wen Hsiung Li; Fiscal Year: 2001
    ..The new methods and some existing methods will used to analyze the data to be obtained. The new methods will be accessible on the World Wide Web. ..
  47. Oleic Acid Effects on Transit and Absorption in SBS
    Charlene Compher; Fiscal Year: 2004
    ....
  48. Molecular Mechanisms of Aging: 33rd Ann. Mtg. of AGE
    Norman Wolf; Fiscal Year: 2004
    ..Dr. Bickford has investigated hotel accommodations there and has found that both the Radisson and the Hilton offer excellent accommodations for the meeting. She is negotiating with both. ..
  49. GENETICS OF AGE SENSITIVE TRAITS IN MICE
    Richard Miller; Fiscal Year: 2003
    ..At best, the program may permit the localization of loci that influence multiple age-sensitive domains and are thus plausible candidates for genes that regulate the rate of aging per se. ..
  50. PREGNANCY ASSOCIATED PROTECTION AGAINST BREAST CANCER
    Frank Talamantes; Fiscal Year: 2002
    ..All these experimental groups and untreated control groups will be injected with carcinogen and tumor incidence compared. ..
  51. IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONS
    David Clemmons; Fiscal Year: 2002
    ....
  52. Role of growth hormone in prostate cancer: rodent models
    Steven Swanson; Fiscal Year: 2002
    ..Our second aim is to determine whether a functional GH receptor is required for carcinogenesis in mice carrying a simian virus 40 (SV4O) large T antigen (Tag) transgene...
  53. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ....
  54. Role of GH deficiency on mitochondrial bioenergetics
    Holly Brown Borg; Fiscal Year: 2005
    ..Determining GH-dependent pathways and mechanisms may suggest potential therapeutic interventions to delay aging, treat aging-related disorders and extend life span in humans. ..
  55. FAMILY-GENETIC STUDY OF YOUTH AT RISK FOR SCHIZOPHRENIA
    Marina Myles Worsley; Fiscal Year: 2007
    ..abstract_text> ..
  56. Genetics of Longevity and Age-Sensitive Traits in Mice
    Richard Miller; Fiscal Year: 2008
    ..abstract_text> ..
  57. Chaperones, ROS systems, & IGF-1:Roles in vascular aging
    David Clemmons; Fiscal Year: 2008
    ..abstract_text> ..
  58. Alcohol: Direct and Indirect Effects in Drug Metabolism
    THOMAS BADGER; Fiscal Year: 2008
    ..abstract_text> ..
  59. MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLS
    David Clemmons; Fiscal Year: 2007
    ..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..
  60. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  61. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  62. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  63. Regulation of Stat Function in Breast Cancer
    CHARLES CLEVENGER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  64. Aldosterone in angiotensin II-induced hypertension
    Rudy Ortiz; Fiscal Year: 2005
    ..Unlike previous studies, the present study will provide a more comprehensive examination of the renal effects induced by aldo antagonism. ..
  65. Role of growth hormone in breast cancer
    Steven Swanson; Fiscal Year: 2006
    ..cross the C3(1)/Tag mouse, which spontaneously develops estrogen independent mammary cancers, with either the GH receptor/binding protein knockout mouse or the GH antagonist mouse...
  66. Function of the PRL Receptor Complex in Breast Cancer
    CHARLES CLEVENGER; Fiscal Year: 2006
    ..Such structure/function analysis of the PRLr isoforms may ultimately provide the basis for novel therapeutic strategies aimed at interrupting the function of the PRL/PRLr complex in human breast cancer. ..
  67. Evolution of Duplicate Genes at the Genomic Level
    Wen Hsiung Li; Fiscal Year: 2005
    ..5. To study the mechanisms of evolution of duplicate genes or how duplicate genes evolve following the duplication event. We shall examine various models for the retention and evolution of duplicate genes. ..

Patents1

  1. Methods for predicting therapeutic response to agents acting on the growth hormone receptor
    Patent Number: WO2004056864-A1; Date:2004-07-08