GRN

Summary

Gene Symbol: GRN
Description: granulin precursor
Alias: CLN11, GEP, GP88, PCDGF, PEPI, PGRN, granulins, PC cell-derived growth factor, acrogranin, granulin-epithelin, proepithelin, progranulin
Species: human

Top Publications

  1. pmc The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice
    Wei Tang
    Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Science 332:478-84. 2011
  2. pmc Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL FL 32224, USA
    Hum Mol Genet 17:3631-42. 2008
  3. ncbi Structure and chromosomal location of the human granulin gene
    V Bhandari
    Royal Victoria Hospital McGill University, Department of Medicine, Montreal, Quebec, Canada
    Biochem Biophys Res Commun 188:57-63. 1992
  4. ncbi Role of progranulin as a biomarker for Alzheimer's disease
    Kristel Sleegers
    Department of Molecular Genetics, CIB, Antwerpen Belgium
    Biomark Med 4:37-50. 2010
  5. doi Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study
    Isabelle Le Ber
    1INSERM, UMR_S679 Neurologie and Thérapeutique Expérimentale, F 75013, Paris, France
    Brain 131:732-46. 2008
  6. doi GRN variability contributes to sporadic frontotemporal lobar degeneration
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 19:171-7. 2010
  7. doi Low serum progranulin predicts the presence of mutations: a prospective study
    Emma C Schofield
    Neuroscience Research Australia and the University of New South Wales, Randwick, Australia
    J Alzheimers Dis 22:981-4. 2010
  8. doi Progranulin (PGRN) expression in ALS: an immunohistochemical study
    D Irwin
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Neurol Sci 276:9-13. 2009
  9. pmc Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN
    J L Whitwell
    Department of Radiology Research, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 72:813-20. 2009
  10. pmc Serum progranulin as an independent marker of liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease
    Yusuf Yilmaz
    Department of Gastroenterology, Marmara University, School of Medicine, Istanbul, Turkey
    Dis Markers 31:205-10. 2011

Research Grants

  1. UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2016
  2. Novel Biomarkers for Aromatase Inhibitor Therapy
    Matthew J Ellis; Fiscal Year: 2013
  3. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine M Benes; Fiscal Year: 2011
  4. Leonard Petrucelli; Fiscal Year: 2014
  5. Lisa Rimsza; Fiscal Year: 2015
  6. Gene expression profiling vs MRD assessment in Myeloma
    Guido J Tricot; Fiscal Year: 2011
  7. Role of Progranulin in Frontotemporal Dementia
    Lauren D Herl; Fiscal Year: 2012
  8. Chuanju Liu; Fiscal Year: 2015
  9. Fenghuang Zhan; Fiscal Year: 2014
  10. Growth Control in Multiple Myeloma
    Bart Barlogie; Fiscal Year: 2013

Detail Information

Publications237 found, 100 shown here

  1. pmc The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice
    Wei Tang
    Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Science 332:478-84. 2011
    The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain unidentified...
  2. pmc Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL FL 32224, USA
    Hum Mol Genet 17:3631-42. 2008
    Loss-of-function mutations in progranulin (GRN) cause ubiquitin- and TAR DNA-binding protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive neurodegenerative disease affecting approximately 10% of early-onset ..
  3. ncbi Structure and chromosomal location of the human granulin gene
    V Bhandari
    Royal Victoria Hospital McGill University, Department of Medicine, Montreal, Quebec, Canada
    Biochem Biophys Res Commun 188:57-63. 1992
    b>Granulins are a family of cysteine rich polypeptides some of which have growth modulatory activity. We showed previously that the granulins are encoded within the same precursor consisting of seven granulin domains arranged in tandem...
  4. ncbi Role of progranulin as a biomarker for Alzheimer's disease
    Kristel Sleegers
    Department of Molecular Genetics, CIB, Antwerpen Belgium
    Biomark Med 4:37-50. 2010
    Serum or plasma progranulin (GRN) is a highly accurate of GRN-related frontotemporal lobar degeneration, which is caused by loss-of-function mutations in the GRN gene...
  5. doi Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study
    Isabelle Le Ber
    1INSERM, UMR_S679 Neurologie and Thérapeutique Expérimentale, F 75013, Paris, France
    Brain 131:732-46. 2008
    ..Since all the mutations cause a progranulin haploinsufficiency, additional factors probably explain the variable clinical presentation of the disease.
  6. doi GRN variability contributes to sporadic frontotemporal lobar degeneration
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 19:171-7. 2010
    Mutations in the progranulin gene (GRN) are responsible for familial FTLD with ubiquitin pathology (FTLD-U). However, there are controversial data regarding the contribution of GRN variability to sporadic FTLD...
  7. doi Low serum progranulin predicts the presence of mutations: a prospective study
    Emma C Schofield
    Neuroscience Research Australia and the University of New South Wales, Randwick, Australia
    J Alzheimers Dis 22:981-4. 2010
    Serum progranulin is decreased in frontotemporal dementia (FTD) patients with progranulin gene (PGRN) mutations. We investigate the utility of prospective serum screening as a surrogate diagnostic marker for progranulin mutations...
  8. doi Progranulin (PGRN) expression in ALS: an immunohistochemical study
    D Irwin
    Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Neurol Sci 276:9-13. 2009
    Mutations in the gene progranulin (PGRN) were recently identified as the cause of some forms of frontotemporal dementia with ubiquitin-positive intraneuronal inclusion pathology (FTLD-U)...
  9. pmc Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN
    J L Whitwell
    Department of Radiology Research, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 72:813-20. 2009
    To compare patterns of gray matter loss in subjects with mutations in the progranulin (PGRN) gene to subjects with mutations in the microtubule-associated protein tau (MAPT) gene.
  10. pmc Serum progranulin as an independent marker of liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease
    Yusuf Yilmaz
    Department of Gastroenterology, Marmara University, School of Medicine, Istanbul, Turkey
    Dis Markers 31:205-10. 2011
    Elevated progranulin levels are associated with visceral obesity, elevated plasma glucose, and dyslipidemia. Progranulin has not been previously investigated as a biomarker of nonalcoholic fatty liver disease (NAFLD)...
  11. pmc Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities
    Dmitri Tolkatchev
    Bio NMR and Protein Research Laboratory, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Protein Sci 17:711-24. 2008
    b>Progranulin is a secreted protein with important functions in several physiological and pathological processes, such as embryonic development, host defense, and wound repair...
  12. pmc Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration
    Alice S Chen-Plotkin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 17:1349-62. 2008
    ..pathway analyses, cluster and principal component analyses, and subgroup analyses based on brain region and progranulin (GRN) gene status...
  13. ncbi Granulins, a novel class of peptide from leukocytes
    A Bateman
    Royal Victoria Hospital McGill University, Department of Medicine, Montreal, Quebec, Canada
    Biochem Biophys Res Commun 173:1161-8. 1990
    ..and characterization of a novel class of leukocyte peptides with possible cytokine-like activities which we call granulins. They are cystine-rich with molecular weights of approximately 6 Kda, except for granulin D, which appears to be ..
  14. ncbi Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins
    D P Trinh
    Department of Biological Sciences, George Washington University, 332 Lisner Hall, 2023 G Street N W, Washington, DC 20052, USA
    Biochem Biophys Res Commun 256:299-306. 1999
    ....
  15. ncbi Clinicopathologic features of frontotemporal dementia with progranulin sequence variation
    S Spina
    Indiana Alzheimer Disease Center, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neurology 68:820-7. 2007
    ..Recently, mutations in Progranulin (PGRN), predicted to cause premature truncation of the PGRN coding sequence, were found in patients with ..
  16. ncbi PC cell-derived growth factor stimulates proliferation and confers Trastuzumab resistance to Her-2-overexpressing breast cancer cells
    Wes E Kim
    A and G Pharmaceutical, Inc, Columbia, Maryland 21045, USA
    Clin Cancer Res 12:4192-9. 2006
    ..PC cell-derived growth factor (PCDGF/GP88) is an 88-kDa glycoprotein growth factor overexpressed in 80% invasive ductal carcinomas...
  17. pmc Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK4 and inactivation of MMP-2
    Yulan Liu
    Cancer Biology Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
    BMC Cancer 7:22. 2007
    PC cell-derived growth factor (PCDGF), also called epithelin/granulin precursor (GEP), is an 88-kDa secreted glycoprotein with the ability to stimulate cell proliferation in an autocrine fashion...
  18. ncbi A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology
    J B Leverenz
    Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Brain 130:1360-74. 2007
    Mutations in the progranulin (GRN) gene have recently been reported as a cause of the frontotemporal dementia (FTD) syndrome...
  19. pmc Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
    Philip Van Damme
    Laboratory of Neurobiology, Flanders Interuniversity Institute for Biotechnology, Katholieke Universiteit Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium
    J Cell Biol 181:37-41. 2008
    Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently sporadic frontotemporal lobe dementia (FTLD)...
  20. doi Progranulin genetic screening in frontotemporal lobar degeneration patients from central Italy
    Silvia Bagnoli
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni, 85, 50134, Florence, Italy
    Cell Mol Neurobiol 32:13-6. 2012
    Recently, mutations in the progranulin gene (GRN) were reported to account for the vast majority of Frontotemporal lobar Degeneration (FTLD) and a growing number of reports describe the implication of this gene in the development of the ..
  21. ncbi Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo
    Z He
    Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    Cancer Res 59:3222-9. 1999
    b>Progranulin is a 593-amino acid glycoprotein, the mRNA of which is expressed by many epithelial cells both in vitro and in vivo, but the biological significance of this expression is unclear...
  22. ncbi The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer
    Monica Brown Jones
    Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892 1500, USA
    Clin Cancer Res 9:44-51. 2003
    ..We hypothesized that new growth factors may be identified through the molecular analysis of ovarian tumors as they exist in their native environment...
  23. pmc The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription
    Mainul Hoque
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07013 1709, USA
    Mol Cell Biol 23:1688-702. 2003
    ..The granulins, mitogenic growth factors containing repeats of a cysteine-rich motif, were reported previously to interact with ..
  24. ncbi Expression of PC-cell-derived growth factor in benign and malignant human breast epithelium
    Ginette Serrero
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy and Program in Oncology, Marlene and Stewart Greenebaum Cancer Center of the University of Maryland, Baltimore, Maryland, USA
    Hum Pathol 34:1148-54. 2003
    PC-cell-derived growth factor (PCDGF, progranulin) is a novel autocrine growth factor that is overexpressed in human breast cancer cell lines...
  25. ncbi A novel deletion in progranulin gene is associated with FTDP-17 and CBS
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Aging 29:427-35. 2008
    ..173) to chromosome 17 and defined a candidate region containing MAPT and PGRN genes. Recombination analysis assigned two different disease haplotypes to FAM047 and FAM071...
  26. pmc Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes
    J C Schymick
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, Maryland, USA
    J Neurol Neurosurg Psychiatry 78:754-6. 2007
    Mutations in the progranulin (PGRN) gene were recently described as the cause of ubiquitin positive frontotemporal dementia (FTD)...
  27. pmc Prominent phenotypic variability associated with mutations in Progranulin
    Brendan J Kelley
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurobiol Aging 30:739-51. 2009
    Mutations in progranulin (PGRN) are associated with frontotemporal dementia with or without parkinsonism...
  28. ncbi Mutations in progranulin gene: clinical, pathological, and ribonucleic acid expression findings
    Adolfo Lopez de Munain
    Servicio de Neurologia, Hospital Donostia, San Sebastian, Spain
    Biol Psychiatry 63:946-52. 2008
    There is an increasing interest in the clinico-pathological correlation of mutations in progranulin (PGRN) and frontotemporal lobar degeneration (FTLD) complex diseases...
  29. ncbi Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion
    Sunita S Shankaran
    Munich Center for Integrated Protein Science and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Schillerstrasse 44, 80336 Munich, Germany
    J Biol Chem 283:1744-53. 2008
    Loss of function mutations in progranulin cause tau-negative frontotemporal lobar degeneration with ubiquitin-positive inclusions...
  30. pmc A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series
    Jonathan Beck
    MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 131:706-20. 2008
    Mutations in the progranulin gene (GRN) are a major cause of frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions (FTLD-U) but the distinguishing clinical and anatomical features of this subgroup remain ..
  31. pmc In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17
    Bernardino Ghetti
    Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Ind 46202, USA
    Neurodegener Dis 5:215-7. 2008
    ..17 (FTDP-17) is associated with mutations in the Microtubule-Associated Protein Tau(MAPT) gene or the Progranulin(PGRN) gene. MAPT mutations lead to widespread deposition of hyperphosphorylated tau protein (FTDP-17T)...
  32. pmc Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN)
    Bradley F Boeve
    Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, Minnesota, 55905, USA
    Arch Neurol 65:460-4. 2008
    ..This conundrum was solved in 2006 with the identification of mutations in the gene encoding progranulin (PGRN; OMIM *138945), which is only 1.7 Mb centromeric to MAPT on chromosome 17...
  33. doi Granulin mutations associated with frontotemporal lobar degeneration and related disorders: an update
    I Gijselinck
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Institute for Biotechnology VIB, Antwerpen, Belgium
    Hum Mutat 29:1373-86. 2008
    Mutations in the gene encoding granulin (HUGO gene symbol GRN, also referred to as progranulin, PGRN), located at chromosome 17q21, were recently linked to tau-negative ubiquitin-positive frontotemporal lobar degeneration (FTLDU)...
  34. doi Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease
    N Brouwers
    VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp Campus CDE, Universiteitsplein 1, B 2610 Antwerpen, Belgium
    Neurology 71:656-64. 2008
    Loss-of-function mutations in the progranulin gene (PGRN) were identified in frontotemporal lobar degeneration (FTLD) with ubiquitin-immunoreactive neuronal inclusions (FTLD-U)...
  35. doi Brain magnetic resonance imaging structural changes in a pedigree of asymptomatic progranulin mutation carriers
    B Borroni
    Department of Neurology, University of Brescia, Brescia, Italy
    Rejuvenation Res 11:585-95. 2008
    Mutations in the progranulin (PGRN) gene have been recently demonstrated as a cause of frontotemporal lobar degeneration (FTLD) with ubiquitin-immunoreactive neuronal inclusion (FTD-U)...
  36. doi Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration
    R Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurology 71:1235-9. 2008
    Mutations in the progranulin gene (PGRN) were identified as the causal mechanism underlying frontotemporal lobar degeneration (FTLD)...
  37. pmc ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor
    Xiao Hui Bai
    Department of Orthopaedic Surgery, New York University School of Medicine, New York, NY 100031, USA
    Mol Cell Biol 29:4201-19. 2009
    ..ADAMTS-7 associates with granulin-epithelin precursor (GEP), an autocrine growth factor that has been implicated in tissue regeneration, tumorigenesis, and inflammation...
  38. pmc Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 18:603-12. 2009
    Mutations in the progranulin gene (GRN), causative for Frontotemporal Lobar Degeneration with ubiquitin-immunoreactive neuronal inclusions (FTLD-U), could also be associated with Alzheimer's disease (AD)...
  39. pmc Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
    Vivianna M Van Deerlin
    1 Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA 2 These authors contributed equally to this work
    Nat Genet 42:234-9. 2010
    ..FTLD-TDP is frequently familial, resulting from mutations in GRN (which encodes progranulin)...
  40. pmc MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia
    Jian Jiao
    Gladstone Institute of Neurological Disease, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e10551. 2010
    b>Progranulin deficiency is thought to cause some forms of frontotemporal dementia (FTD), a major early-onset age-dependent neurodegenerative disease. How progranulin (PGRN) expression is regulated is largely unknown...
  41. doi Phenotypic heterogeneity of the GRN Asp22fs mutation in a large Italian kindred
    Anna M Pietroboni
    Department of Neurological Sciences, University of Milan, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 24:253-9. 2011
    The Asp22fs(g.63_64insC) mutation in progranulin gene (GRN) has been so far reported in one patient who developed frontotemporal dementia (FTD) at the age of 65...
  42. pmc Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia
    Basar Cenik
    Department of Neuroscience, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9111, USA
    J Biol Chem 286:16101-8. 2011
    b>Progranulin (GRN) haploinsufficiency is a frequent cause of familial frontotemporal dementia, a currently untreatable progressive neurodegenerative disease...
  43. pmc Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients
    Paola Bossù
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Neuroinflammation 8:65. 2011
    The progranulin gene (PGRN) encodes a pleiotropic molecule with anti-inflammatory actions and neuronal protective effects...
  44. doi From genotype to phenotype: two cases of genetic frontotemporal lobar degeneration with premorbid bipolar disorder
    Chiara Cerami
    Neurorehabilitation Unit, Department of Clinical Neurosciences, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy
    J Alzheimers Dis 27:791-7. 2011
    ..Recently, the progranulin gene (GRN) was reported to be involved in the disease pathogenesis...
  45. pmc Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells
    Phyllis Fung Yi Cheung
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e28246. 2011
    ..We have previously demonstrated that granulin-epithelin precursor (GEP), a pluripotent growth factor, is upregulated in HCC but not in the adjacent non-tumor, and that GEP is a potential ..
  46. pmc Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage
    Katherine R Smith
    Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Am J Hum Genet 90:1102-7. 2012
    ..Unexpectedly, we found these siblings to be homozygous for a c.813_816del (p.Thr272Serfs∗10) mutation in the progranulin gene (GRN, granulin precursor) in the latter peak...
  47. pmc Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance
    Hua Qu
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    Mediators Inflamm 2013:360190. 2013
    ..In this study, we aim to investigate the concentrations of plasma progranulin in Chinese patients with obesity (OB) and type 2 diabetes mellitus (T2DM), and its relationship to IR...
  48. pmc Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains
    V Bhandari
    Endocrine Laboratory, Royal Victoria Hospital, Department of Medicine, McGill University, Montreal, Canada
    Proc Natl Acad Sci U S A 89:1715-9. 1992
    b>Granulins are candidate growth factors recently discovered in human and rat inflammatory leukocytes and bone marrow. Two granulin homologs, epithelin 1 and 2, occur in the rat kidney...
  49. ncbi The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth
    G D Plowman
    Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121
    J Biol Chem 267:13073-8. 1992
    ..The broad expression profile of epithelin transcripts, along with the opposing activities of the two mature protein products, implicates these factors as natural mediators of epithelial homeostasis...
  50. ncbi Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line
    J Zhou
    W Alton Jones Cell Science Center, Inc, Lake Placid, New York 12946
    J Biol Chem 268:10863-9. 1993
    ..b>Granulins are small polypeptides purified from granulocyte extracts with no apparent biological functions...
  51. pmc Structural and functional analysis of a promoter of the human granulin/epithelin gene
    V Bhandari
    Endocrine Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada
    Biochem J 319:441-7. 1996
    b>Granulins (grns) or epithelins (epis) are peptides with molecular masses of approx. 6 kDa that modulate the growth of cells...
  52. ncbi Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair
    Jing Zhu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell 111:867-78. 2002
    ..b>Proepithelin (PEPI), an epithelial growth factor, can be converted to epithelins (EPIs) in vivo by unknown mechanisms with ..
  53. ncbi Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis
    Ginette Serrero
    A and G Pharmaceutical Inc, Columbia, MD 21045, USA
    Biochem Biophys Res Commun 308:409-13. 2003
    PC-cell derived growth factor (PCDGF), also known as granulin precursor or progranulin, is the largest member of a family of growth modulators characterized by a unique cysteine-rich motif...
  54. ncbi Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma
    Siu Tim Cheung
    Centre for the Study of Liver Disease and Departments of Surgery and Pathology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Cancer Res 10:7629-36. 2004
    Granulin-epithelin precursor (GEP) is a novel growth factor. Our earlier cDNA microarray study indicated that GEP was overexpressed in hepatocellular carcinoma (HCC)...
  55. ncbi Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation
    Mainul Hoque
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103 2714, USA
    J Biol Chem 280:13648-57. 2005
    ..The interactions of granulins with Tat and cyclin T1 differ with respect to their binding sites and divalent cation requirements, and we ..
  56. ncbi Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Nature 442:920-4. 2006
    ..Here we demonstrate that FTDU-17 is caused by mutations in the gene coding for progranulin (PGRN), a growth factor involved in multiple physiological and pathological processes including tumorigenesis...
  57. ncbi Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
    Matt Baker
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Nature 442:916-9. 2006
    ..Here we demonstrate that in these families, FTD is caused by mutations in progranulin (PGRN) that are likely to create null alleles. PGRN is located 1.7 Mb centromeric of MAPT on chromosome 17q21...
  58. ncbi Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration
    Jennifer Gass
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Hum Mol Genet 15:2988-3001. 2006
    Null mutations in the progranulin gene (PGRN) were recently reported to cause tau-negative frontotemporal dementia linked to chromosome 17...
  59. pmc HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin
    Odity Mukherjee
    Washington University Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 60:314-22. 2006
    ..inclusions in the brain linked to 17q21-22 recently has been reported to carry null mutations in the progranulin gene (PGRN)...
  60. ncbi Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center and Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 64:43-7. 2007
    ..Primary progressive aphasia (PPA) is a language-based dementia characterized by fluent or nonfluent language disorder as its principal feature...
  61. ncbi Progranulin mutations in Dutch familial frontotemporal lobar degeneration
    Iraad F Bronner
    Department of Human Genetics, Section Medical Genomics, VU University Medical Center and VU University, Amsterdam, The Netherlands
    Eur J Hum Genet 15:369-74. 2007
    Mutations in the progranulin (PGRN) gene have recently been identified in frontotemporal lobar degeneration with ubiquitin inclusions linked to chromosome 17q21...
  62. ncbi Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    J Neuropathol Exp Neurol 66:142-51. 2007
    ..ubiquitin-positive neuronal inclusions are the most common, and some have mutations in the gene for progranulin (PGRN)...
  63. pmc Progranulin in frontotemporal lobar degeneration and neuroinflammation
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    J Neuroinflammation 4:7. 2007
    b>Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries of mutations in the gene for PGRN that cause frontotemporal lobar degeneration (FTLD)...
  64. pmc Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations
    Jennifer L Whitwell
    Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 64:371-6. 2007
    Mutations in the progranulin gene (PGRN) have recently been identified as a cause of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) in some families.
  65. ncbi Progranulin null mutations in both sporadic and familial frontotemporal dementia
    Isabelle Le Ber
    INSERM, UMR679, Paris, France
    Hum Mutat 28:846-55. 2007
    Frontotemporal dementia (FTD) is the second most frequent type of neurodegenerative dementias. Mutations in the progranulin gene (GRN, PGRN) were recently identified in FTDU-17, an FTD subtype characterized by ubiquitin-immunoreactive ..
  66. ncbi The neuropathology and clinical phenotype of FTD with progranulin mutations
    Ian R A Mackenzie
    Department of Pathology, Vancouver General Hospital, 855 West 12th Avenue, Vancouver, BC, Canada
    Acta Neuropathol 114:49-54. 2007
    Mutations in the progranulin gene (PGRN), on chromosome 17q21, have recently been identified as a major cause of familial frontotemporal dementia (FTD)...
  67. ncbi Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations
    Vivianna M Van Deerlin
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1148-53. 2007
    Patients with frontotemporal dementia due to mutation of progranulin may have a distinct phenotype.
  68. ncbi Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Lancet Neurol 6:857-68. 2007
    The progranulin gene (GRN) is mutated in 5-10% of patients with frontotemporal lobar degeneration (FTLD) and in about 20% of patients with familial FTLD. The most common mutation in GRN is Arg493X...
  69. ncbi Progranulin locus deletion in frontotemporal dementia
    I Gijselinck
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Institute for Biotechnology VIB, University of Antwerp, Antwerpen, Belgium
    Hum Mutat 29:53-8. 2008
    Ubiquitin-positive, tau-negative, frontotemporal dementia (FTD) is caused by null mutations in progranulin (PGRN; HUGO gene symbol GRN), suggesting a haploinsufficiency mechanism...
  70. pmc Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia
    Odity Mukherjee
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Hum Mutat 29:512-21. 2008
    ..characterized cases of FTLD-U with or without motor neuron disease (MND) were screened for mutations in the progranulin gene (GRN; also PGRN)...
  71. doi Progranulin genetic variability contributes to amyotrophic lateral sclerosis
    K Sleegers
    Neurodegenerative Brain Diseases Group, VIB Department of Molecular Genetics, University of Antwerp, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Neurology 71:253-9. 2008
    Null mutations in progranulin (PGRN) cause ubiquitin-positive frontotemporal dementia (FTD) linked to chromosome 17q21 (FTDU-17)...
  72. doi Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations
    Stuart M Pickering-Brown
    Clinical Neuroscience Research Group, Faculty of Medical and Human Sciences, University of Manchester, Oxford Rd, Manchester M13 9PT, UK
    Brain 131:721-31. 2008
    ..MND), for whom genomic DNA was available, were investigated for the presence of mutations in tau (MAPT) and progranulin (PGRN) genes...
  73. doi Progranulin genetic variations in frontotemporal lobar degeneration: evidence for low mutation frequency in an Italian clinical series
    Barbara Borroni
    Department of Neurology, University of Brescia, Brescia, Italy
    Neurogenetics 9:197-205. 2008
    ..It has been reported that mutations within progranulin (PGRN) gene are a major cause of FTLD in the USA and worldwide, counting for 5-10% of FTLD and for 20-25% of ..
  74. doi Deletion of the progranulin gene in patients with frontotemporal lobar degeneration or Parkinson disease
    Anne Rovelet-Lecrux
    INSERM U 614, Faculty of Medicine, Institute for Biomedical Research, 76000 Rouen, France
    Neurobiol Dis 31:41-5. 2008
    b>Progranulin gene (PGRN) mutations cause ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17 (FTLDU-17)...
  75. pmc Gene expression study on peripheral blood identifies progranulin mutations
    Giovanni Coppola
    Department of Neurology, Program in Neurogenetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Ann Neurol 64:92-6. 2008
    ..We screened total-blood progranulin (PGRN) levels in 107 patients with neurodegenerative dementias and related conditions, and 36 control subjects, ..
  76. doi Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia
    John C van Swieten
    Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands
    Lancet Neurol 7:965-74. 2008
    ..20-30% of cases of FTD follow an autosomal dominant pattern of inheritance, and half of which are caused by defects in MAPT, CHMP2B, and VCP...
  77. doi Cortical atrophy and language network reorganization associated with a novel progranulin mutation
    Carlos Cruchaga
    Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, 31008 Spain
    Cereb Cortex 19:1751-60. 2009
    ..We identified a novel Cys521Tyr progranulin gene variant in a PNFA family that potentially disrupts disulphide bridging causing protein misfolding...
  78. doi Low prevalence of progranulin mutations in Finnish patients with frontotemporal lobar degeneration
    J Kruger
    Department of Neurology, University of Oulu, Oulu, Finland
    Eur J Neurol 16:27-30. 2009
    Mutations in the progranulin (PGRN) gene have recently been associated with frontotemporal lobar degeneration (FTLD). The frequency of these mutations varies between populations...
  79. pmc Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue
    Byung Soo Youn
    AdipoGen, College of Life Science and Biotechnology, Korea University, Seoul, Korea
    Diabetes 58:627-36. 2009
    b>Progranulin is an important molecule in inflammatory response...
  80. pmc Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members
    NiCole Finch
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain 132:583-91. 2009
    Mutations in the progranulin gene (GRN) are an important cause of frontotemporal lobar degeneration (FTLD) with ubiquitin and TAR DNA-binding protein 43 (TDP43)-positive pathology...
  81. pmc Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth
    Giada Monami
    Department of Urology, Thomas Jefferson University, 233 South 10th St, BLSB Room 620, Philadelphia, PA 19107, USA
    Am J Pathol 174:1037-47. 2009
    The growth factor proepithelin has recently emerged as an important regulator of transformation in several physiological and pathological systems...
  82. doi Progranulin expression in advanced human atherosclerotic plaque
    Yoji Kojima
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Atherosclerosis 206:102-8. 2009
    b>Progranulin (PGRN) is a unique growth factor that plays an important role in cutaneous wound healing. It has an anti-inflammatory effect and promotes cell proliferation...
  83. doi No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration
    Sara Rollinson
    Clinical Neurosciences Research Group, Faculty of Human and Medical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Neurobiol Aging 32:754-5. 2011
    ..It has been claimed that homozygosity of the SNP rs5848 located in the 3'UTR of progranulin increases risk for FTLD...
  84. doi GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease
    B Jasinska-Myga
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Eur J Neurol 16:909-11. 2009
    A single nucleotide polymorphism in the 3'-untranslated region of the progranulin gene (GRN; 3'UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)...
  85. doi The granulin gene family: from cancer to dementia
    Andrew Bateman
    Endocrine Research Laboratory, McGill University Health Centre, Royal Victoria Hospital, Montreal, Canada
    Bioessays 31:1245-54. 2009
    The growth factor progranulin (PGRN) regulates cell division, survival, and migration. PGRN is an extracellular glycoprotein bearing multiple copies of the cysteine-rich granulin motif...
  86. doi "Frontotemporoparietal" dementia: clinical phenotype associated with the c.709-1G>A PGRN mutation
    F Moreno
    Department of Neurology, Hospital Donostia, Paseo Dr Begiristain sn, CP 20014, San Sebastian, Gipuzkoa, Spain
    Neurology 73:1367-74. 2009
    Mutations in the progranulin gene (PGRN) are a major cause of frontotemporal lobar degeneration with tau-negative and ubiquitin-positive neuronal inclusions...
  87. doi Expression of progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in benign and malignant ovarian tumors and activation of MAPK signaling in ovarian cancer cell line
    R Cuevas-Antonio
    UMAE de Ginecologia y Obstetricia Luis Castelazo Ayala, IMSS, Mexico D F, Mexico
    Cancer Invest 28:452-8. 2010
    It has been recently demonstrated that progranulin is overexpressed in ovarian cancer and that this protein is involved in the stimulation of cell proliferation, malignancy, and chemoresistance in ovarian cancer...
  88. pmc Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes
    Milena De Riz
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122 Milan, Italy
    Neurosci Lett 469:234-6. 2010
    b>Progranulin has recently attracted attention due to the discovery of mutations in its encoding gene (GRN) in several cases of frontotemporal lobar degeneration, but also for a possible role in inflammatory processes...
  89. pmc Pathogenic cysteine mutations affect progranulin function and production of mature granulins
    Jun Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurochem 112:1305-15. 2010
    Frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U) can be caused by mutations in the progranulin gene (GRN)...
  90. pmc Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations
    Jonathan D Rohrer
    Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 53:1070-6. 2010
    ..Nine patients with progranulin (GRN) mutations and eleven patients with microtubule-associated protein tau (MAPT) mutations had T1 MR brain ..
  91. ncbi HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins
    Hanayuki Okura
    Department of Somatic Stem Cell Therapy, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation, Kobe 650 0047, Japan
    J Atheroscler Thromb 17:568-77. 2010
    ..We hypothesized that HDL suppresses the conversion of macrophage-secreted factors into proinflammatory factors via binding, and tried to identify the factor that could form a complex with HDL and/or apolipoprotein (apo) A-I...
  92. pmc miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease
    Wang Xia Wang
    Department of Pathology, Division of Neuropathology, and the Sanders Brown Center on Aging, Rm 311, Sanders Brown Center, 800 S Limestone, University of Kentucky, Lexington, KY 40536 0230, USA
    Am J Pathol 177:334-45. 2010
    Granulin (GRN, or progranulin) is a protein involved in wound repair, inflammation, and neoplasia. GRN has also been directly implicated in frontotemporal dementia and may contribute to Alzheimer's disease pathogenesis...
  93. doi Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance
    Siu Tim Cheung
    Department of Surgery, The University of Hong Kong, Hong Kong, China
    Gastroenterology 140:344-55. 2011
    ..Gene expression profiling studies have shown that hepatic cancer cells express granulin-epithelin precursor (GEP); we investigated its role in hepatic cancer stem cell functions and chemoresistance.
  94. pmc rs5848 polymorphism and serum progranulin level
    Ging Yuek R Hsiung
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada
    J Neurol Sci 300:28-32. 2011
    To assess the influence of rs5848 polymorphism in serum progranulin (PGRN) level in a cohort of subjects with Alzheimer and related dementias from a tertiary referral clinic.
  95. pmc Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Am J Hum Genet 87:890-7. 2010
    Recent studies suggest progranulin (GRN) is a neurotrophic factor...
  96. pmc TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers
    N Finch
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurology 76:467-74. 2011
    ..whether TMEM106B single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients with and without mutations in progranulin (GRN) and to determine whether TMEM106B modulates GRN expression.
  97. pmc Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β
    Xue Gao
    Department of Neurology, Lurie Cancer Center, Center for Genetic Medicine Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Protein Cell 1:552-62. 2010
    b>Progranulin (PGRN) has recently emerged as a key player in a subset of frontotemporal dementias (FTD)...
  98. doi Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia
    Carolina Alquezar
    Department of Cellular and Molecular Medicine, Centro de Investigaciones Biologicas CSIC, Madrid, Spain
    Neurobiol Aging 33:429.e7-20. 2012
    ..containing TAR DNA binding protein 43 (TDP-43) is associated in most cases with null-mutations in the progranulin gene (PGRN)...
  99. doi Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase
    Anja Capell
    German Center for Neurodegenerative Diseases, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurosci 31:1885-94. 2011
    Numerous loss-of-function mutations in the progranulin (GRN) gene cause frontotemporal lobar degeneration with ubiquitin and TAR-DNA binding protein 43-positive inclusions by reduced production and secretion of GRN...
  100. pmc Low plasma progranulin levels in children with autism
    Laila Y Al-Ayadhi
    Autism Research and Treatment Center, AL Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 8:111. 2011
    ..Local administration of recombinant progranulin, which is an anti-inflammatory neurotrophic factor, potently inhibit neutrophilic inflammation in vivo, ..
  101. pmc Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism
    Gabriel Frampton
    Department of Internal Medicine, Texas A and M Health Science Center College of Medicine, Temple, TX 76504, USA
    Gut 61:268-77. 2012
    Cholangiocarcinoma is a devastating cancer of biliary origin with limited treatment options. The growth factor, progranulin, is overexpressed in a number of tumours...

Research Grants80

  1. UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2016
    ..We will also perform gene expression profiling (GEP) of the carcinoma cells that I generate to determine if we can generate a signature that predicts antiestrogen ..
  2. Novel Biomarkers for Aromatase Inhibitor Therapy
    Matthew J Ellis; Fiscal Year: 2013
    ..is independent of pathological stage and grade and forms the basis for a preoperative endocrine prognostic index (PEPI)...
  3. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine M Benes; Fiscal Year: 2011
    ..We recently tested this hypothesis using gene expression profiling (GEP), together with a novel post hoc analysis of GenMapp biopathways/clusters...
  4. Leonard Petrucelli; Fiscal Year: 2014
    ..provided by applicant): We found that null mutations in the gene encoding the secreted growth factor progranulin (PGRN) are a frequent cause of frontotemporal dementia, particularly in patients affected with the pathological ..
  5. Lisa Rimsza; Fiscal Year: 2015
    ..The LLMPP is uniquely posed to accomplish this work by virtue of having performed the "gold standard" GEP experiments that define the diagnostic and prognostic distinctions in these lymphomas as well as holding matching ..
  6. Gene expression profiling vs MRD assessment in Myeloma
    Guido J Tricot; Fiscal Year: 2011
    ..In Aim 2, we will identify the gene expression profile (GEP) associated with high risk of early progression versus prolonged remission and describe its component genes and ..
  7. Role of Progranulin in Frontotemporal Dementia
    Lauren D Herl; Fiscal Year: 2012
    ..It is the second most common cause of dementia in persons under the age of 65. Recently, mutations in the progranulin gene (GRN) were discovered to cause tau-negative, ubiquitin-positive cases of FTD (1-5)...
  8. Chuanju Liu; Fiscal Year: 2015
    ..In a global screen for the binding proteins of progranulin (PGRN) growth factor, we found that PGRN bound to TNFR1 and TNFR2...
  9. Fenghuang Zhan; Fiscal Year: 2014
    ..Furthermore, gene expression profiling (GEP) will be performed on myeloma samples in remission and at relapse who also have GEP at baseline to identify genes ..
  10. Growth Control in Multiple Myeloma
    Bart Barlogie; Fiscal Year: 2013
    ..work will interrogate the MM-ME interaction and elucidate, through examination of serial gene expression profiling (GEP) samples, how this interaction affects growth control...
  11. Progranulin, TAR DNA binding protein-43 and Cell Death
    Leonard Petrucelli; Fiscal Year: 2009
    PROJECT/SUMMARY ABSTRACT We recently found that null mutations in the gene encoding the secreted growth factor progranulin (PGRN) are a frequent cause of frontotemporal dementia, particularly in patients affected with the pathological ..
  12. Susan D Reynolds; Fiscal Year: 2014
    ..We will use gene expression profiling (GEP) to determine if: 1) the normal human and mouse TBE is populated by molecularly-distinct subsets of basal cells;and ..
  13. S Sakura Minami; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Mutations in the progranulin gene cause frontotemporal dementia (FTD), the second most common age-related dementia after Alzheimer's disease...
  14. Bruce L Miller; Fiscal Year: 2016
    ..therapies for FTLD with ubiquitin-TDP-43 inclusions, FTLD with tau inclusions, and FTLD associated with progranulin mutations...
  15. Molecular mechanism underlying Frontotemporal Lobar Regeneration
    David Medina; Fiscal Year: 2013
    ..Loss-of-function mutations in the progranulin (PGRN) gene have been shown to be one of the leading causes of FTLD...
  16. Alice S Chen-Plotkin; Fiscal Year: 2016
    ..be either sporadic or familial, with a substantial proportion of cases (~10%) attributable to mutations in the progranulin gene (GRN)...
  17. Personalized Medicine for Colorectal and Breast Cancer
    Kathryn A Phillips; Fiscal Year: 2010
    ..of genomic risk stratification and targeted treatment by using the examples of gene expression profiling (GEP) and HER2/neu testing for trastuzumab (Herceptin(r)) for breast cancer...
  18. Michael Emmerson Ward; Fiscal Year: 2015
    ..We observed a similar phenotype in a mouse model of familial FTLD caused by loss of expression of the protein progranulin (PGRN)...
  19. Ginette Serrero; Fiscal Year: 2014
    ..It has been demonstrated recently that 5-10% of all FTD in the US are caused by mutations in the Progranulin (PGRN) gene. This is accompanied with a 50% reduction of PGRN level in patients'biological fluids...
  20. Enhancing Progranulin Expression - a Therapy for Frontotemporal Dementia
    JOACHIM J contact HERZ; Fiscal Year: 2010
    ..Loss-offunction mutations in the human progranulin gene (GRN) account for ~20% of cases of familial FTD via a disease mechanism of GRN haploinsufficiency (loss of ..
  21. Stephen M Strittmatter; Fiscal Year: 2015
    ..Amongst FTD cases, the most common cause has been recognized recently to be inherited mutation in the Progranulin (PGRN) gene. This genetic insight has the potential to lead to rational and effective therapies for FTD...
  22. Andrew Nguyen; Fiscal Year: 2014
    ..I propose to focus on a new candidate for mediating HDL's anti-inflammatory property. Progranulin is a secreted growth factor that is expressed in many tissues and circulates in the blood...
  23. Carlos Cruchaga; Fiscal Year: 2016
    ..from 27 families with three or more affected individuals each and no mutations in APP, PSEN1, PSEN2, MAPT, GRN and C9ORF72. Sequencing data for additional 20 families will be included...
  24. Christopher D Link; Fiscal Year: 2016
    ..TDP-43-positive inclusions occur in FTLD cases caused by loss-of-function mutations in progranulin but the biological connection between TDP-43 and progranulin has not been established...
  25. Bruce L Miller; Fiscal Year: 2016
    ..from FTD patients carrying common mutations in the genes currently known to cause FTD: tau (MAPT), C9ORF72, and progranulin (GRN). In Aim 1, we will recruit both FTD patients with defined genetic mutations and control subjects...
  26. Richard B Lipton; Fiscal Year: 2016
    ..Project 4 will assess the role of progranulin (GRN) deficiency in the development of hippocampal pathology in humans and in transgenic mice subjected to ..
  27. Ronald C Petersen; Fiscal Year: 2016
    ..research projects: 1) Identifying Multi-modality Imaging Correlates of Dementia with Lewy Bodies and AD, 2) The PGRN/TDP-43 Axis in Alzheimer's Disease and Neurodegeneration, and 3) Identification of AD Risk Variants by Genome ..
  28. Amanda J Myers; Fiscal Year: 2016
    ..to Chromosome 17 (FTDP-17), mutations in both the microtubule associated protein Tau gene (MAPT) as well as Progranulin (PRGN) have been found. Both MAPT and PRGN map within the same linkage peak on chromosome 17...
  29. Kelly A Birdwell; Fiscal Year: 2015
    ..through the Clinical and Translational Science Award (CTSA) group and the Pharmacogenomics Research Network (PGRN), as well as the collaborative milieu of Vanderbilt, to provide a comprehensive mentored educational and research ..
  30. Jason P Mulvenna; Fiscal Year: 2016
    ..O. viverrini granulin, termed Ov-GRN-1, is widely expressed in fluke tissues, including gut and tegument...
  31. Elaine R Mardis; Fiscal Year: 2014
    ..abstract_text> ..
  32. Jenny T Mao; Fiscal Year: 2015
    ..IL)-6, IL-10, IL-12 and C-reactive protein (CRP);5) cancer relevant, pathway specific gene expression profiles (GEP);and 6) epigenetic profiles assessed by micro(mi) RNA expression in BAL cells, bronchial brushing and biopsies...
  33. Impact of maternal HAART on HIV-infected breastfeeding infants: Malawi
    Susan H Eshleman; Fiscal Year: 2013
    ..This hypothesis will be tested using samples and data from the Post-Exposure Prophylaxis of Infants (PEPI) trial that was conducted in Blantyre, Malawi...
  34. Gene regulatory network evolution and the origin of biological novelties
    MARK MARTINDALE; Fiscal Year: 2013
    ..Gene regulatory networks (GRN) controlling the specification of endomesodermal cell fates have been constructed in a handful of model systems, ..
  35. Metabolomics Network for Drug Response Phenotype
    RIMA F KADDURAH DAOUK; Fiscal Year: 2010
    ..Network for Drug Response Phenotype and two centers of excellence within the Pharmacogenomics Research Network (PGRN)(both networks funded by NIGMS) for the purpose of gaining deeper understanding of mechanisms of variation in ..
  36. Muna I Naash; Fiscal Year: 2016
    ..We propose to accomplish this by first studying the epigenetic regulation of the pEPi-ABCA4 vector to understand the mechanisms that underlie gene silencing (Aim 1), then implement targeted vector ..
  37. ALBERTHA JOHANNA WALHOUT; Fiscal Year: 2016
    ..g. at the level of an organ, tissue or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators, e.g...
  38. Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin
    Xiaojing Ma; Fiscal Year: 2011
    ..The current project focuses on the cellular and molecular mechanisms whereby progranulin (PGRN) and secretory leukocyte protease inhibitor (SLPI), two host-derived anti-inflammatory proteins, regulate ..
  39. Xiuqian Mu; Fiscal Year: 2015
    ..cells (RPCs), progresses in a stepwise fashion, and is regulated by a hierarchical gene regulatory network (GRN)...
  40. Richard L Maas; Fiscal Year: 2016
    ..These studies provide mechanistic information about the gene regulatory network (GRN) that controls vertebrate lens development...
  41. GNOTOBIOTIC TRANSGENIC MODELS OF THE GASTRIC ECOSYSTEM
    JEFFREY IVAN GORDON; Fiscal Year: 2010
    ..and this potentially dangerous 'liaison'influence Hp genome evolution and gastric epithelial progenitor (GEP) biology: (1) Define Hp genome evolution as individual human hosts progress to ChAG and to cancer...
  42. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
    ..One such alternative is a long- known anti-inflammatory growth factor, progranulin (PGRN), which was only recently discovered to be a novel ligand of TNF receptors (TNFR) in our global genetic ..
  43. Ales Cvekl; Fiscal Year: 2016
    ..We have now identified a "core" gene regulatory network (GRN), comprised of Pax6, c-Maf and crystallin genes, which is responsible for lens-specific expression of all ..
  44. Progranulin: Mutation and Regulation in Neurodegenerative disease
    Rosa Rademakers; Fiscal Year: 2012
    ..We recently found that loss-of- function mutations in the gene encoding the secreted growth factor progranulin (PGRN) are an important cause of the most common pathological subtype of FTLD, characterized by neuronal ..
  45. Aaron M Zorn; Fiscal Year: 2016
    ..to play key roles in endoderm development, and how these TFs functionally interact in a gene regulatory network (GRN) is poorly understood and the extent to which they modulate endoderm patterning and early organogenesis is unknown...
  46. Gene Function Profiling of Neural Crest Cell Diversification
    Christine E Beattie; Fiscal Year: 2013
    ..Together, these results have identified a framework gene regulatory network (GRN) that initiates NC diversification...
  47. Satish Gopal; Fiscal Year: 2014
    ..These analyses will be used to define gene expression profiles (GEP) of diffuse large B-cell, Burkitt, and Hodgkin lymphoma specimens...
  48. Targeted Therapy for Non Small Cell Lung Carcinoma: In vivo Feasibility Studies
    Ginette Serrero; Fiscal Year: 2012
    ..These activities have led to the discovery of the 88 kDa granulin precursor (GP88), an autocrine growth factor preclinically validated as playing a role in NSCLC tumorigenesis...
  49. James C Mulloy; Fiscal Year: 2014
    ..The gene expression profiles (GEP) of these clones could be highly informative with regard to the specific signaling cascades that correlate with ..
  50. Andrea Morrione; Fiscal Year: 2016
    ..We have established that the growth factor progranulin plays a critical role in bladder cancer by regulating motility and invasion of malignant urothelial cells and ..
  51. JOSHUA PATRICK LEWIS; Fiscal Year: 2016
    ..324 mg) on 1-year survival in approximately 1,400 PCI patients recruited as part of the PGRN-funded Pharmacogenomics of Anti-Platelet Intervention 2 (PAPI-2) Study...
  52. Richard M Weinshilboum; Fiscal Year: 2014
    ..This proposal represents a request for continued funding of the Mayo Clinic Pharmacogenomics Research Network (PGRN) grant "Pharmacogenetics of Phase II Drug Metabolizing Enzymes"...
  53. Richard L Maas; Fiscal Year: 2016
    ..In the prior grant period, we developed important new methods for reconstructing the gene regulatory network (GRN) that underlies early molar tooth formation, and we identified a unique E-M Wnt-Bmp4 feedback circuit that controls ..
  54. Chuanju Liu; Fiscal Year: 2016
    ..Our genome-wide screen for novel, differentially expressed genes in OA led to the isolation of progranulin (PGRN) as a novel OA-associated growth factor...
  55. Gene regulatory study of pigment cell development in sea urchins
    Cristina Calestani; Fiscal Year: 2010
    ..regions of a differentiation gene will be used as a bottomup approach to uncover the structure of the GRN regulating the specification and differentiation processes of pigment cells...
  56. STUART ALEXANDER SCOTT; Fiscal Year: 2016
    ..will be accomplished through Clinical and Translational Science Award (CTSA)/Pharmacogenomics Research Network (PGRN)- based co-mentorship, collaboration, and the practical and didactic mechanisms outlined in this application...
  57. Leonard Petrucelli; Fiscal Year: 2015
    ..RNA-immunoprecipitation studies in human HEK293T cells identified sortilin (SORT1), a neuronal progranulin (PGRN) receptor, as a TDP-43 target. Mutations in GRN are a major cause of FTLD-TDP...
  58. Pharmacogenomics of a Cytidine Analogue, Gemcitabine
    Liewei Wang; Fiscal Year: 2010
    ..of NIH-Mayo initiatives, including the NIH Comprehensive Cancer Center, the NIH Pharmacogenetics Research Network (PGRN) grant and the NIH Pancreatic Cancer SPORE...
  59. TNF SIGNALING IN THE ABSENCE OF FUNCTIONAL TNF RECEPTORS.
    EDOUARD M CANTIN; Fiscal Year: 2012
    ..nTNFR will characterized in term of its pattern of expression, ligand binding including LT-a and Progranulin, the newly identified ligand for p75 (TNFR2), structural relationship to p55 and p75, conservation in humans ..
  60. Pharmacogenomics of Breast Cancer Adjuvant Chemotherapy
    Richard M Weinshilboum; Fiscal Year: 2011
    ..breast cancer clinical trial group in Germany and the Mayo Clinic NIH Pharmacogenetics Research Network (PGRN) Center-a center with a commitment to pharmacogenomic studies of breast cancer...
  61. Building a Gene Regulatory Network for prdm1a During Zebrafish Craniofacial Devel
    KRISTI A LAMONICA; Fiscal Year: 2013
    ..Lastly, to further build the GRN of the posterior face, I am screening the F2 generation from an ENU mutagenesis screen to identify novel posterior ..
  62. Comparative Pharmaco-oncogenomics of Myeloma Drug Resistance
    Peter Leif Bergsagel; Fiscal Year: 2013
    ..We will identify the genetic (DNA copy and GEP) changes in paired samples from patients before and after relapse from drug treatment and compare to similarly ..
  63. Brianne Magouirk Bettcher; Fiscal Year: 2016
    ..Bettcher will also examine the role of an upstream regulator of inflammation (i.e. progranulin) in cognitive functions and its association with brain structure (Aim 3)...
  64. Julie C Baker; Fiscal Year: 2014
    ..Yet the gene regulatory networks (GRN) of these transcription factors and the transcriptional responses to them are still largely unexplored in any ..
  65. Iron Delivery Via hemodialysate in ESRD
    Ajay Gupta; Fiscal Year: 2005
    ..will be adjusted every 6 weeks, according to a protocol, with the goal of maintaining hemoglobin between 11 to 12 grn/dl. Safety parameters will be carefully monitored throughout the trial...
  66. ALBERTHA JOHANNA WALHOUT; Fiscal Year: 2016
    ..Many GRN studies focus either solely on physical TF interactions, whereas others focus primarily on regulatory interactions...
  67. Mark J Ratain; Fiscal Year: 2014
    ..Extensive collaborative clinical studies are proposed with CALGB, as well as other current PGRN Groups. Other ongoing collaborations will be continued, including studies of glucuronidation and LCLs...
  68. AIMEE KAO; Fiscal Year: 2014
    PROJECT SUMMARY Despite recent progress, it is unclear how progranulin deficiency leads to development of the neurodegenerative disease frontotemporal lobar degeneration (FTLD)...
  69. Establishing Therapeutic Efficacy in Frontotemporal Degeneration
    Howard J Rosen; Fiscal Year: 2013
    ..Recent advances in our understanding of the most common disease-causative genes for familial FTD (tau, progranulin, or C9ORF72) have led to targeted therapeutics that are entering early stage clinical trial pilot studies...
  70. Resistance in HIV-infected infants after extended ARV prophylaxis: PEPI-Malawi
    Susan H Eshleman; Fiscal Year: 2010
    ..test this hypothesis by analyzing samples and data from the Post-Exposure Prophylaxis of Infants in Malawi trial (PEPI-Malawi)...
  71. Guo Cheng Yuan; Fiscal Year: 2015
    ..developed systems biology-based approaches to integrate multiple data-types and construct gene regulatory networks (GRN) centered on GWAS candidates and from these, use the local network to predict functions of the uncharacterized ..
  72. NOVEL AGENT TO RESTORE SENSITIVITY TO ANTI-ESTROGEN THERAPY
    PH D SERRERO; Fiscal Year: 2012
    ..The PI has characterized a growth factor, GP88, and demonstrated its critical role in the development, proliferation and survival of cancer cells...
  73. Jonathon T Hill; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Deciphering the gene regulatory networks (GRN) that drive differentiation in the developing embryo is essential for identifying mutations that cause th disease and developing novel treatments for ..
  74. A novel signaling mechanism of Progranulin
    Fenghua Hu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mutations in Progranulin (PGRN), a gene encoding a secreted glycoprotein, are the major cause of Frontotemporal Lobar Degeneration with ubiquitin positive inclusions (FTLD-U)...
  75. Progestin Levels and Inflammation in Postmenopause
    Peifeng Hu; Fiscal Year: 2007
    ..data from 459 participants from the active treatment arms of the Postmenopausal Estrogen Progestin Intervention (PEPI) randomized clinical trial to assess how serum levels of progestins are related to inflammatory marker levels and ..
  76. Sex Steroids & Mammographic Density in the Postmenopause
    Gail Greendale; Fiscal Year: 2007
    ..This study is an outgrowth of the Postmenopausal Estrogen/Progestin Interventions (PEPI) trial, which randomly assigned postmenopausal women to placebo, estrogen-only, or one of three combination ..
  77. Phase I Application: Cleaning of Single Cell DNA Measurements In-Silico
    Matthew Rabinowitz; Fiscal Year: 2007
    ..As a member of the NIH Pharmacogenetics Research Network (PGRN), PharmGKB's database includes extensive pharmacokinetic and genomic records from cardiovascular, pulmonary, ..
  78. Estrogen, Inflammation and Cardiovascular Risk
    David Reuben; Fiscal Year: 2003
    ..This study will use data from the NHLBI-funded Postmenopausal Estrogen Progestin Intervention (PEPI) randomized clinical trial to assess the effect of conjugated equine estrogens (CEE) with or without progestins ..
  79. GERM LAYER SPECIFICATION
    DAVID MC CLAY; Fiscal Year: 2007
    ..into endoderm and mesoderm, and we collaborated in the assembly of a large provisional Gene Regulatory Network (GRN) model for endomesoderm cell specification...
  80. High Resolution Microarray Analysis of Cancer
    Cheng Ming Chuong; Fiscal Year: 2002
    ..We hope to achieve high resolution GEP using Laser Capture Micro-dissection microscopy to dissect histopathology sections...