GRM5

Summary

Gene Symbol: GRM5
Description: glutamate metabotropic receptor 5
Alias: GPRC1E, MGLUR5, PPP1R86, mGlu5, metabotropic glutamate receptor 5, glutamate receptor, metabotropic 5, protein phosphatase 1, regulatory subunit 86
Species: human

Top Publications

  1. pmc Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, USA
    Anat Rec (Hoboken) 294:1635-45. 2011
  2. ncbi Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins
    Jun Kitano
    Department of Biological Sciences, Faculty of Medicine, Graduate School of Biostudies, Kyoto University, Kyoto, 606 8501, Japan
    J Neurosci 22:1280-9. 2002
  3. ncbi Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins
    B Xiao
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:707-16. 1998
  4. ncbi A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated so
    Arne Heydorn
    Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:54291-303. 2004
  5. ncbi Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus
    M Le Vasseur
    Departement de Physiologie, Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Neuroscience 151:28-42. 2008
  6. ncbi Heterogeneity of metabotropic glutamate receptors in autonomic cell groups of the medulla oblongata of the rat
    M Hay
    Dalton Cardiovascular Research Center, Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211, USA
    J Comp Neurol 403:486-501. 1999
  7. ncbi Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
    Y M Lu
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Neurosci 17:5196-205. 1997
  8. ncbi Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
    A Pisani
    Clinica Neurologica, Dipartmento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuroscience 106:579-87. 2001
  9. ncbi Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5
    Simon M Ametamey
    Center for Radiopharmaceutical Science of ETH, PSI and USZ and Department of Chemistry and Applied Biosciences of ETH, CH 8093 Zurich, Switzerland
    J Nucl Med 47:698-705. 2006
  10. pmc Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei
    Silvarosa Grassi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, Perugia I 06100, Italy
    J Physiol 543:795-806. 2002

Research Grants

  1. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2010
  2. The Role of Intracellular Metabotropic Glutamate Receptor 5 at the Synapse
    CAROLYN ANN PURGERT; Fiscal Year: 2012
  3. FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPES
    Jeffrey P Conn; Fiscal Year: 2013
  4. Hui Chen Lu; Fiscal Year: 2015
  5. Jelena Radulovic; Fiscal Year: 2016
  6. HING HUNG HENRY LAI; Fiscal Year: 2016
  7. Kimberly Huber; Fiscal Year: 2015
  8. PDZ scaffold regulation of astrocytic glutamate receptors and transporters
    Randy A Hall; Fiscal Year: 2012
  9. Targeting Glial mGluR5 in Schizophrenia
    Francesca Cicchetti; Fiscal Year: 2013
  10. Role of mGluR5 positive allosteric modulators in schizophrenia
    ALEXIS SHEA HAMMOND; Fiscal Year: 2011

Detail Information

Publications476 found, 100 shown here

  1. pmc Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, USA
    Anat Rec (Hoboken) 294:1635-45. 2011
    ..Additionally, we found that levels of metabotropic glutamate receptor 5 (mGluR5) protein were significantly increased in vermis of children with autism versus age and ..
  2. ncbi Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins
    Jun Kitano
    Department of Biological Sciences, Faculty of Medicine, Graduate School of Biostudies, Kyoto University, Kyoto, 606 8501, Japan
    J Neurosci 22:1280-9. 2002
    ..of tamalin and dominant-negative tamalin facilitated and reduced the neuritic distribution of endogenous mGluR5 in cultured hippocampal neurons, respectively...
  3. ncbi Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins
    B Xiao
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:707-16. 1998
    ..These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties...
  4. ncbi A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated so
    Arne Heydorn
    Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:54291-303. 2004
    ..It is concluded that the tail library provides useful information on the general importance of certain adaptor proteins, for example, in this case, ruling out EBP50 as being a broad spectrum-recycling adaptor...
  5. ncbi Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus
    M Le Vasseur
    Departement de Physiologie, Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Neuroscience 151:28-42. 2008
    ..However these interneurons also express mGluR5 and the contribution of this receptor subtype in interneuron synaptic plasticity remains unexplored...
  6. ncbi Heterogeneity of metabotropic glutamate receptors in autonomic cell groups of the medulla oblongata of the rat
    M Hay
    Dalton Cardiovascular Research Center, Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211, USA
    J Comp Neurol 403:486-501. 1999
    ..of the present study was to examine the localization and expression of four types of mGluRs: mGluRla, mGluR2/3, mGluR5, and mGluR7 in the dorsal and ventral autonomic nuclei of the medulla of the rat...
  7. ncbi Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
    Y M Lu
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Neurosci 17:5196-205. 1997
    ..To test the involvement of one member of this class, we have recently generated mutant mice that express no mGluR5 but normal levels of other glutamate receptors. The CNS revealed normal development of gross anatomical features...
  8. ncbi Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
    A Pisani
    Clinica Neurologica, Dipartmento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuroscience 106:579-87. 2001
    ..were potentiated in the presence of both the group I mGluR agonist 3,5-dihydroxyphenylglycine (3,5-DHPG) and the mGluR5 selective agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG)...
  9. ncbi Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5
    Simon M Ametamey
    Center for Radiopharmaceutical Science of ETH, PSI and USZ and Department of Chemistry and Applied Biosciences of ETH, CH 8093 Zurich, Switzerland
    J Nucl Med 47:698-705. 2006
    ..3-(6-methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-(11)C-methyl-oxime), a noncompetitive and highly selective antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), was evaluated for its potential as a PET agent.
  10. pmc Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei
    Silvarosa Grassi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, Perugia I 06100, Italy
    J Physiol 543:795-806. 2002
    ..role of group II and III metabotropic glutamate receptors (mGluRs) and of the subtypes of group I mGluRs: mGluR1, mGluR5, was investigated in basal synaptic transmission and in the induction and maintenance of long-term potentiation (..
  11. doi Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex
    K Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Neuroscience 156:203-15. 2008
    ..In the present study, we have investigated the expression and cell-specific distribution of group I (mGluR1, mGluR5), group II (mGluR2/3) and group III (mGluR4 and mGluR8) mGluR subtypes in human TSC specimens of both cortical ..
  12. doi ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities
    Feng Liu
    Wyeth Neuroscience Discovery Research, Princeton, New Jersey, USA
    J Pharmacol Exp Ther 327:827-39. 2008
    Positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGlu5) enhance N-methyl-d-aspartate receptor function and may represent a novel approach for the treatment of schizophrenia...
  13. ncbi Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction
    T Abe
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    J Biol Chem 267:13361-8. 1992
    A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic glutamate receptor (mGluR) family and by ..
  14. ncbi Expression of a functional metabotropic glutamate receptor 5 on enteric glia is altered in states of inflammation
    Yasmin Nasser
    Institute for Infection, Immunity and Inflammation, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Glia 55:859-72. 2007
    The metabotropic glutamate receptor 5 (mGluR5) is expressed by astrocytes and its expression is modulated by inflammation...
  15. pmc Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration
    M Behnam Ghasemzadeh
    Department of Biomedical Sciences, Integrative Neuroscience Research Center, Marquette University, Milwaukee, WI 53201, United States
    Neurosci Lett 452:167-71. 2009
    This study examined the role of group1 metabotropic glutamate receptor mGluR5 and associated postsynaptic scaffolding protein Homer1b/c in behavioral plasticity after three withdrawal treatments from cocaine self-administration...
  16. ncbi Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo
    Anthony C Vernon
    Department of Cellular and Molecular Neuroscience, Faculty of Medicine, Imperial College London, Charing Cross Campus, London, UK
    J Neurochem 103:1075-91. 2007
    ..neurones is regulated by the activation of Group I metabotropic glutamate receptors (mGluR), comprising mGluR1 and mGluR5 subtypes...
  17. ncbi Effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors
    Mark H Pitcher
    Department of Anesthesia, McGill University, Montreal, Quebec, Canada
    J Comp Neurol 505:412-23. 2007
    ..Plasticity of group I metabotropic glutamate receptors (mGluR1 and mGluR5) is important in various neuronal systems, and these receptors are also known to modulate nociceptive ..
  18. ncbi Radiolabeling and in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET radioligand for the metabotropic glutamate receptor subtype 5
    Michael Honer
    Animal Imaging Center PET, Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Hoenggerberg, CH 8093 Zurich, Switzerland
    Nucl Med Biol 34:973-80. 2007
    ..FE-DABP688 was radiolabeled with fluorine-18 and characterized as a PET imaging agent for the metabotropic glutamate receptor subtype 5 (mGluR5).
  19. pmc Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake
    Joyce Besheer
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biol Psychiatry 67:812-22. 2010
    ..This study sought to evaluate the functional role of Group I (mGluR5) and Group II (mGluR2/3) in mesocorticolimbic brain regions in ethanol self-administration.
  20. pmc Metabotropic glutamate receptors in the main olfactory bulb drive granule cell-mediated inhibition
    Thomas Heinbockel
    Department of Anatomy, Howard University College of Medicine, 520 W Street NW, Washington, DC 20059, USA
    J Neurophysiol 97:858-70. 2007
    ..bulb (MOB) granule cells (GCs) express high levels of the group I metabotropic glutamate receptor (mGluR), mGluR5. We investigated the role of mGluRs in regulating GC activity in rodent MOB slices using whole cell patch-clamp ..
  21. ncbi Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses
    Yelin Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232 6600, USA
    Mol Pharmacol 71:1389-98. 2007
    ..made in the discovery of selective positive allosteric modulators of the metabotropic glutamate receptor (mGluR) mGluR5. These compounds may provide a novel approach that could be useful in the treatment of certain central nervous ..
  22. ncbi Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5
    Richard L Young
    Nerve Gut Research Laboratory, Level 1 Hanson Institute, Adelaide, SA, Australia
    Am J Physiol Gastrointest Liver Physiol 292:G501-11. 2007
    Metabotropic glutamate receptors (mGluR) are classified into group I, II, and III mGluR. Group I (mGluR1, mGluR5) are excitatory, whereas group II and III are inhibitory...
  23. ncbi Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices
    Angela C Lee
    Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
    J Neurophysiol 88:1625-33. 2002
    ..The mGluR1 antagonist (S)-(+)-alpha-amino-4-carboxy-2-methylbenzeneacetic acid (LY 367385; 25-100 microM) and the mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP; 10-50 microM), applied separately, significantly reduced the ..
  24. ncbi Role of metabotropic glutamate receptor subtype 5 (mGluR5) in the maintenance of cold hypersensitivity following a peripheral mononeuropathy in the rat
    M O Urban
    Department of Behavioral Pharmacology, Merck Research Laboratories, San Diego, CA 92121, USA
    Neuropharmacology 44:983-93. 2003
    ..series of experiments were designed to examine the contribution of metabotropic glutamate receptor subtype 5 (mGluR5) to neuropathic pain by determining the effects of the selective mGluR5 antagonist MPEP (2-methyl-6-(phenylethynyl)..
  25. pmc Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking
    Vidhya Kumaresan
    Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, United States
    Behav Brain Res 202:238-44. 2009
    ..Results indicated that systemic administration of the mGluR5 antagonists 2-methyl-6-(phenylethynyl)pyridine (MPEP: 1 and 3mg/kg i.p...
  26. doi Pretreatment with group I metabotropic glutamate receptors antagonists attenuates lethality induced by acute cocaine overdose and expression of sensitization to hyperlocomotor effect of cocaine in mice
    Jolanta Kotlinska
    Department of Pharmacology and Pharmacodynamics, Medical University, Staszica 4, 20 081 Lublin, Poland
    Neurotox Res 19:23-30. 2011
    ..the present study was to test, whether group I metabotropic glutamate receptors (mGluRs) antagonists (mGluR1 and mGluR5) differentially regulate toxic versus behavioral effects of cocaine, both phenomena relevant to the ..
  27. ncbi [Expression of metabotropic glutamate receptor 5 in spinal cord of morphine tolerant rats]
    Jin bian Liu
    Department of Anesthesiology, Shanghai Sixth People s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
    Zhonghua Yi Xue Za Zhi 89:2221-4. 2009
    To investigate the expression of metabotropic glutamate receptor 5 (mGluRS) in spinal cord of morphine tolerant rats and understand the influence of mGluR5 antagonist MPEP upon the expression of mGluRS.
  28. ncbi Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus
    Olga V Poisik
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 23:122-30. 2003
    ..Here, we report that group I mGluR1 and mGluR5 have distinct functional roles in type II neurons of the rat globus pallidus (GP)...
  29. ncbi N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors
    Yelin Chen
    Department of Pharmacology, Vanderbilt University Medical Center, 23rd Avenue South at Pierce, 417 D Preston Research Building, Nashville, TN 37232 6600, USA
    Mol Pharmacol 73:909-18. 2008
    ..studies suggest that a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor (mGluRs), mGluR5, termed 4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (VU-29), potentiates mGluR5 responses by actions at a ..
  30. ncbi The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons
    Limin Mao
    Department of Basic Medical Science, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri 64108, USA
    J Neurosci 25:2741-52. 2005
    ..We found that selective activation of mGluR5, but not mGluR1, increased ERK1/2 phosphorylation...
  31. pmc Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro
    Sergey Neyman
    Institute for Physiology of the Charite, Synaptic Plasticity Research Group, Humboldt University, Berlin, Germany
    Eur J Neurosci 27:1345-52. 2008
    The group I metabotropic glutamate receptors, mGluR1 and mGluR5, exhibit differences in their regulation of synaptic plasticity, suggesting that these receptors may subserve separate functional roles in information storage...
  32. ncbi SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5
    M A Varney
    SIBIA Neurosciences, Inc, La Jolla, California, USA
    J Pharmacol Exp Ther 290:170-81. 1999
    ..This functional screen was used to identify the mGluR5-selective antagonist, SIB-1757 [6-methyl-2-(phenylazo)-3-pyridinol], which inhibited the glutamate-induced [Ca2+]i ..
  33. ncbi The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles
    Geoffrey B Varty
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Psychopharmacology (Berl) 179:207-17. 2005
    ..Modulation of metabotropic glutamate receptor (mGluR) subtypes represents a novel approach for the treatment of neurological and psychiatric disorders...
  34. ncbi mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: a developmental study
    A Valerio
    Department of Biomedical Sciences and Biotechnologies, Brescia University School of Medicine, Italy
    Neurosci Res 28:49-57. 1997
    ..A polyclonal antibody raised against the carboxy-terminal portion of mGluR5 was used to study the distribution of the receptor in rat foetal (Et15), neonatal (P8) and adult spinal cords and ..
  35. ncbi Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5
    Ji Quan Wang
    Experimental PET Laboratory, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Synapse 61:951-61. 2007
    The metabotropic glutamate receptor subtype 5 (mGluR5) has been reported to be implicated in various neurological disorders in the central nervous system...
  36. pmc Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity
    Alice L Rodriguez
    Department of Pharmacology, Vanderbilt Program in Drug Discovery, Vanderbilt University Medical Center, 2215 Garland Avenue, Nashville, TN 37232 0697, USA
    Mol Pharmacol 78:1105-23. 2010
    Modulators of metabotropic glutamate receptor subtype 5 (mGluR5) may provide novel treatments for multiple central nervous system (CNS) disorders, including anxiety and schizophrenia...
  37. ncbi Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice
    Giuseppe Battaglia
    Istituto Neurologico Mediterraneo Neuromed, 86077 Pozzilli, Italy
    J Neurosci 24:828-35. 2004
    ..MPEP) and (E)-2-methyl-6-(2-phenylethenyl)-pyridine (SIB1893)] to examine whether endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the pathophysiology of nigro-striatal damage in the 1-methyl-4-..
  38. ncbi Comparative analysis of the subcellular and subsynaptic localization of mGluR1a and mGluR5 metabotropic glutamate receptors in the shell and core of the nucleus accumbens in rat and monkey
    Darlene A Mitrano
    Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 500:788-806. 2007
    ..their effects in the ventral striatum, we studied the subcellular and subsynaptic localization of mGluR1a and mGluR5 in the shell and core of the nucleus accumbens in rat and monkey...
  39. ncbi Human PET studies of metabotropic glutamate receptor subtype 5 with 11C-ABP688
    Simon M Ametamey
    Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Department of Chemistry and Applied Biosciences of ETH, Zurich, Switzerland
    J Nucl Med 48:247-52. 2007
    3-(6-Methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-11C-methyl-oxime (11C-ABP688), a noncompetitive and highly selective antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), was evaluated for its potential as a PET agent.
  40. ncbi Regulator of G-protein signaling 4 interacts with metabotropic glutamate receptor subtype 5 in rat striatum: relevance to amphetamine behavioral sensitization
    Marek Schwendt
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 323:650-7. 2007
    ..In the brain, both RGS4 and mGluR5 receptors are enriched in the striatum, and their functions have been linked to psychostimulant-induced behavior ..
  41. ncbi Rapid direct excitation and long-lasting enhancement of NMDA response by group I metabotropic glutamate receptor activation of hypothalamic melanin-concentrating hormone neurons
    Hao Huang
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:11560-72. 2007
    The effect of group I metabotropic glutamate receptor (mGluR1 and mGluR5) activation on identified melanin-concentrating hormone (MCH) neurons was studied using patch-clamp recording in hypothalamic slices from green fluorescent protein-..
  42. doi Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the micro-opioid receptor
    H Schroder
    Dept of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Neuropharmacology 56:768-78. 2009
    ..of the micro-opioid receptor (MOR) in human embryonic kidney (HEK) 293 cells which co-express metabotropic glutamate receptor 5 (mGluR5)...
  43. pmc A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease
    C Keywood
    Addex Pharma SA, Plan les Ouates, CH 1228 Switzerland
    Gut 58:1192-9. 2009
    In preclinical models, antagonism of metabotropic glutamate receptor 5 (mGluR5) reduces transient lower oesophageal sphincter relaxations (TLOSRs) and increases LOS pressure...
  44. doi Modulation of intracellular calcium mobilization and GABAergic currents through subtype-specific metabotropic glutamate receptors in neonatal rat hippocampus
    M Taketo
    Department of Physiology 1, Faculty of Medicine, Kansai Medical University, 10 15 Fumizono cho Moriguchi, Osaka 570 8506, Japan
    Brain Res Bull 81:73-80. 2010
    ..In hippocampal interneurons, several subclasses of mGluRs including mGluR1 and mGluR5 have been immunohistochemically identified...
  45. pmc Regulation of group I metabotropic glutamate receptor expression in the rat striatum and prefrontal cortex in response to amphetamine in vivo
    Christopher Shaffer
    Department of Anesthesiology, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Brain Res 1326:184-92. 2010
    ..Group I mGluRs (mGluR1 and mGluR5 subtypes) are expressed in striatal medium spiny output neurons and are believed to play an important role in the ..
  46. ncbi Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: I. Metabotropic receptors
    M E Blue
    The Kennedy Krieger Research Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Comp Neurol 386:16-28. 1997
    ..Immunocytochemical studies of phosphoinositide-linked mGluRs, mGluR5 and mGluR1alpha, showed that the developmental expression of mGluR5 mirrored that of the pattern of ..
  47. ncbi Spinal axonal injury transiently elevates the level of metabotropic glutamate receptor 5, but not 1, in cord-projection central neurons
    Yueh Jan Wang
    Department of Anatomy, College of Medicine, Tzu Chi University, Taiwan
    J Neurotrauma 21:479-89. 2004
    ..metabotropic receptors, the expression of group I metabotropic glutamate receptors, mGluR1 and mGluR5, was examined following similar treatment...
  48. ncbi [Activation of mGluRI in neutrophils promotes the adherence of neutrophils to endothelial cells]
    Xue Yun Liu
    Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, China
    Sheng Li Xue Bao 62:219-24. 2010
    ..Immunocytochemistry and real-time quantitative RT-PCR were used to detect the expression of mGluRI (mGluR1 and mGluR5) in neutrophils...
  49. doi Receptor-receptor interactions within receptor mosaics. Impact on neuropsychopharmacology
    K Fuxe
    Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden
    Brain Res Rev 58:415-52. 2008
    ..Based on the likely existence of A(2A)/D(2)/mGluR5 RM located both extrasynaptically on striato-pallidal GABA neurons and on cortico-striatal glutamate terminals, ..
  50. ncbi An increased expression of the mGlu5 receptor protein following LTP induction at the perforant path-dentate gyrus synapse in freely moving rats
    D Manahan-Vaughan
    Synaptic Plasticity Research Group, Johannes Mueller Institute for Physiology, Humboldt University Medical Faculty Charité, Berlin, Germany
    Neuropharmacology 44:17-25. 2003
    ..An up-regulation of mGlu5 receptors was observed in the hippocampus both 24 and 48 h following LTP induction...
  51. ncbi The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms
    G Gegelashvili
    NeuroScience PharmaBiotec Research Center, Department of Pharmacology, Royal Danish School of Pharmacy, Copenhagen, Denmark
    Neurochem Int 37:163-70. 2000
    ..machinery for differential regulation of GLAST via the astroglial metabotropic glutamate receptors, mGluR3 and mGluR5. Thus, long-term treatment with the group I mGluR agonist, DHPG, causes down-regulation of GLAST, whereas the ..
  52. pmc Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function
    Sergi Ferre
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, U SA
    Proc Natl Acad Sci U S A 99:11940-5. 2002
    ..and in vivo evidence for a synergism between adenosine and glutamate based on subtype 5 metabotropic glutamate (mGluR5) and adenosine A2A (A2AR) receptor/receptor interactions...
  53. ncbi 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity
    Nicholas D P Cosford
    Merck Research Laboratories, MRLSDB2, 3535, General Atomics Court, San Diego, California 92121, USA
    J Med Chem 46:204-6. 2003
    2-Methyl-6-(phenylethynyl)pyridine (3), a potent noncompetitive mGlu5 receptor antagonist widely used to characterize the pharmacology of mGlu5 receptors, suffers from a number of shortcomings as a therapeutic agent, including off-target ..
  54. ncbi Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer
    Noah W Gray
    Molecular Neuroscience Program and Graduate School, Mayo Clinic, 200 First Street, S W, Rochester, MN 55905, USA
    Curr Biol 13:510-5. 2003
    ..These data suggest that Dyn3 is a postsynaptic dynamin and, like its binding partner Homer, plays a significant role in dendritic spine morphogenesis and remodeling...
  55. ncbi Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats
    Volker Herzig
    Neuropharmacology, Zoological Institute, Faculty of Biology, University of Tubingen, Germany
    Addict Biol 10:243-9. 2005
    ..MPEP), a highly selective antagonist of metabotropic glutamate receptors subtype 5 (mGluR5), in conditioned drug reward...
  56. pmc Alpha1-adrenergic receptor-induced heterosynaptic long-term depression in the bed nucleus of the stria terminalis is disrupted in mouse models of affective disorders
    Zoe A McElligott
    Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neuropsychopharmacology 33:2313-23. 2008
    ..In addition, alpha(1)-AR LTD was induced independently of the activation of mGluR5 which can also induce LTD in this region...
  57. doi Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice
    Ming Huan Chan
    Institute of Pharmacology and Toxicology, Tzu Chi University, 701, Section 3, Chung Yang Road, Hualien, 970, Taiwan
    Psychopharmacology (Berl) 198:141-8. 2008
    Recent studies have shown that metabotropic glutamate receptor 5 (mGluR5) can modulate N-methyl-D-aspartate receptor function...
  58. pmc Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine
    Donna M Platt
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 200:167-76. 2008
    The mGluR5 antagonist MPEP has effects that suggest potential as a pharmacotherapy for cocaine addiction...
  59. doi Focal degeneration of astrocytes in amyotrophic lateral sclerosis
    D Rossi
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Cell Death Differ 15:1691-700. 2008
    ..astrocytes are highly vulnerable to glutamate and undergo cell death mediated by the metabotropic type-5 receptor (mGluR5)...
  60. doi Ca2+ oscillation induced by P2Y2 receptor activation and its regulation by a neuron-specific subtype of PKC (gammaPKC)
    Noriaki Ashida
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Rokkodai cho 1 1, Nada Ku, Kobe 657 8501, Japan
    Neurosci Lett 446:123-8. 2008
    ..This [Ca2]i oscillation was distinct from that induced by metabotropic glutamate receptor 5 (mGluR5) stimulation in the frequency (72.3 +/- 5.3 mHz) and in the regulatory mechanism.
  61. doi Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease
    Tom H Johnston
    Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Ontario, Canada
    J Pharmacol Exp Ther 333:865-73. 2010
    ..pharmacodynamic effects on behavior of the orally active, selective metabotropic glutamate receptor type 5 (mGlu5) antagonist, 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) (as the hydrochloride salt) in the 1-methyl-4-..
  62. doi Analysis of gene expression changes associated with long-lasting synaptic enhancement in hippocampal slice cultures after repetitive exposures to glutamate
    Katsuhiro Kawaai
    Department of Chemistry and Biological Science, School of Science and Engineering, Aoyama Gakuin University, Kanagawa, Japan
    J Neurosci Res 88:2911-22. 2010
    ..were identified, 1) genes previously reported to be induced by physiological as well as epileptic activity (bdnf, grm5, rgs2, syt4, ania4/carp/dclk) and 2) genes involved in cofilin-based regulation of actin filament dynamics (ywhaz, ..
  63. pmc Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:1489-98. 2010
    ..For example, group I metabo-tropic glutamate receptors (mGluR1α, mGluR5) modulate both GABA and gluta-mate systems...
  64. pmc Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5)
    Christopher M Olsen
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e15085. 2010
    Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food...
  65. doi Phencyclidine treatment increases NR2A and NR2B N-methyl-D-aspartate receptor subunit expression in rats
    Sylwia Owczarek
    Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, University of Copenhagen, Denmark
    Neuroreport 22:935-8. 2011
    ..In this study, expression of different NMDAR subunits, the postsynaptic mGlu5 receptor and the connecting NMDAR-mGluR5 intracellular postsynaptic density proteins have been measured in adult rats after treatment with phencyclidine on ..
  66. doi Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression
    Z A Hughes
    Neuroscience Research Unit, Pfizer Global Research, 700 Main Street, Cambridge, MA 02139, USA
    Neuropharmacology 66:202-14. 2013
    ..describe the in vitro and in vivo profile of GRN-529, a novel negative allosteric modulator (NAM) of metabotropic glutamate receptor 5 (mGluR5). In cell based pharmacology assays, GRN-529 is a high affinity (Ki 5.4 nM), potent (IC50 3...
  67. doi Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine
    Nicholas E Clifton
    Neuroscience Research and Development Unit, Institut de Recherches Servier, 125 Chemin de Ronde, Croissy sur Seine, Paris, France
    Psychopharmacology (Berl) 225:579-94. 2013
    Metabotropic glutamate-5 receptors (mGluR5), which physically and functionally interact with N-methyl-D-Aspartate (NMDA) receptors, likewise control cognitive processes and have been proposed as targets for novel classes of antipsychotic ..
  68. doi Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats
    Kieran Rea
    Pharmacology and Therapeutics, School of Medicine, University Road, National University of Ireland, Galway, Ireland
    Pain 154:576-85. 2013
    ..and interactions with GABAergic (GABAA receptor) and glutamatergic (metabotropic glutamate receptor type 5; mGluR5) signalling in the BLA in formalin-evoked nociceptive behaviour and FCA in rats...
  69. doi β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors
    Amulya Nidhi Shrivastava
    Biologie Cellulaire de la Synapse, Institut de Biologie de l Ecole Normale Supérieure, INSERM U1024 CNRS 8197, Paris 75005, France
    Glia 61:1673-86. 2013
    ..Thus, Aβ oligomer- and mGluR5-dependent ATP release by astrocytes may contribute to the overall deleterious effect of mGluR5s in Alzheimer's ..
  70. pmc mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matching/non-matching-to-sample task
    Amber L Lacrosse
    Department of Psychology, Arizona State University, Tempe, AZ, USA
    Psychopharmacology (Berl) 232:251-8. 2015
    Positive allosteric modulators (PAMs) of type 5 metabotropic glutamate receptors (mGluR5) exert pro-cognitive effects in animal models of various neuropsychiatric diseases...
  71. ncbi Activation of group I metabotropic glutamate receptors regulates the excitability of rat retinal ganglion cells by suppressing Kir and I h
    Qian Li
    Institutes of Brain Science, Fudan University, 138 Yixueyuan Rd, Shanghai, 200032, China
    Brain Struct Funct . 2016
    ..Extracellular application of LY367385 (10 µM)/MPEP (10 µM), selective mGluR1 and mGluR5 antagonists, respectively, significantly reduced the firing frequency, suggesting that glutamate endogenously ..
  72. pmc mGluR1 and mGluR5 Synergistically Control Cholinergic Synaptic Transmission in the Thalamic Reticular Nucleus
    Yan Gang Sun
    Department of Neurobiology and Anatomy, McGovern Medical School, Houston, Texas 77030, Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 36:7886-96. 2016
    ..Both the induction and the maintenance of mGluR-nLTP require synergistic activation of mGluR1 and mGluR5. Together, our results show that postsynaptic Group I mGluRs are critically involved in the regulation of ..
  73. ncbi SIRT1 attenuates neuropathic pain by epigenetic regulation of mGluR1/5 expressions in type 2 diabetic rats
    Cheng Hua Zhou
    Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China
    Pain 158:130-139. 2017
    ..Furthermore, the expressions of metabotropic glutamate receptor (mGluR1) and mGluR5, which play a key role in central sensitization and neuropathic pain, and H3 acetylation levels at Grm1/5 (..
  74. ncbi Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity
    G Mannaioni
    Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, Italy
    Neuropharmacology 38:917-26. 1999
    ..DHPG (3-100 microM), an agonist of both mGlu1 and mGlu5 receptors, and CHPG (1000 microM), a low affinity mGlu5 agonist, produced qualitatively similar effects...
  75. ncbi Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia
    Lindsey J Hudson
    Oxford GlycoSciences Ltd, Abingdon, OX14 4RY, United Kingdom
    J Neurosci 22:2660-8. 2002
    b>Metabotropic glutamate receptor 5 (mGluR5) protein increased after sciatic nerve section in ipsilateral L4 and L5 DRG neuronal profiles, with most of the increase occurring in myelinated A-fiber somata...
  76. ncbi Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus
    Masahiko Tomiyama
    Third Department of Medicine, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki 036 8216, Japan
    Brain Res Mol Brain Res 136:275-81. 2005
    ..In diabetic (STZ-induced) rats, the levels of expression of mGluR1 mRNA and mGluR5 mRNA were significantly increased in all layers of the dorsal horn...
  77. ncbi Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats
    Anton Y Bespalov
    Institute of Pharmacology, Pavlov Medical University, St Petersburg, Russia
    Neuropharmacology 49:167-78. 2005
    Previous studies suggested that metabotropic glutamate 5 (mGlu5) receptors play an important role in the reinforcing effects of abused drugs...
  78. ncbi Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment
    David H Overstreet
    Bowles Center for Alcohol Studies and Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    Addict Biol 11:356-73. 2006
    ..decrease alcohol intake in the FH/Wjd rats include the 5-hydroxytryptamine-2A receptor antagonist, amperozide, the mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) and herbal derivatives such as ibogaine, ..
  79. ncbi Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists
    Jared B J Milbank
    Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Bioorg Med Chem Lett 17:4415-8. 2007
    Rational replacement of the alkyne linker of mGluR5 antagonist MPEP gave 7-arylquinolines. SAR optimization gave an orally active compound with high affinity for the MPEP binding site.
  80. pmc Tonic activation of GLUK5 kainate receptors decreases neuroblast migration in whole-mounts of the subventricular zone
    Jean Claude Platel
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, FMB 422, New Haven, CT 06520 8082, USA
    J Physiol 586:3783-93. 2008
    ..AMPA/kainate receptors as well as metabotropic glutamate receptors subtype 5 (mGluR5) are expressed in SVZ cells...
  81. doi Open-label treatment trial of lithium to target the underlying defect in fragile X syndrome
    Elizabeth Berry-Kravis
    Department of Pediatrics, Rush University Medical Center, University of Illinois at Chicago, IL 60612, USA
    J Dev Behav Pediatr 29:293-302. 2008
    ..X mental retardation protein (FMRP) disrupts regulation of group 1 metabotropic glutamate receptor (mGluR and mGluR5)-dependent translation in dendrites...
  82. doi Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability
    J P Clement
    Department of Anatomy, Wyeth Applied Neurophysiology Group, University of Bristol School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Eur J Neurosci 29:2347-62. 2009
    ..acid (LY367385), an antagonist of mGluR1, but not 2-methyl-6-(phenylethynyl)pyridine hydrochloride (MPEP), an mGluR5 inhibitor...
  83. doi The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function
    Laia Canela
    IDIBAPS, CIBERNED and Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 111:555-67. 2009
    ..Overall, these findings indicate that NECAB2 by its physical interaction with mGlu(5b) receptor modulates receptor function...
  84. pmc Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and colocalization with the metabotropic glutamate receptor 5 in the striatum
    James W Bogenpohl
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    J Comp Neurol 520:570-89. 2012
    ..rodents, the therapeutic efficacy of A(2A) R modulation is improved by concomitant modulation of the metabotropic glutamate receptor 5 (mGluR5)...
  85. doi Glutamate receptors in tendinopathic patients
    Nikos Schizas
    Orthopedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    J Orthop Res 30:1447-52. 2012
    ..Moreover, we examined the presence of metabotropic receptors that increase (mGluR1 and mGluR5) or decrease (mGluR6 and mGluR7) NMDAR1 excitability...
  86. doi Targeting glutamate system for novel antipsychotic approaches: relevance for residual psychotic symptoms and treatment resistant schizophrenia
    Andrea de Bartolomeis
    Laboratory of Molecular Psychiatry and Psychopharmacotherapeutics, Department of Neuroscience, University School of Medicine Federico II, Naples, Italy
    Eur J Pharmacol 682:1-11. 2012
    ..N-methyl-D-aspartate (NMDA) receptor activity by NMDA-Rs co-agonists, glycine transporters inhibitors, AMPAkines, mGluR5 agonists, NMDA-Rs partial agonists...
  87. doi Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression
    C F Cavarsan
    Department of Physiology, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Epilepsy Res 101:253-60. 2012
    Homer1a regulates expression of group I metabotropic glutamate receptors type I (mGluR1 and mGluR5) and is involved in neuronal plasticity...
  88. doi Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits
    Emilie Campanac
    INSERM, UMR_S 1072, F 13344 Marseille, France Aix Marseille Université, UNIS, F 13344 Marseille, France
    Neuron 77:712-22. 2013
    ..LTP-IE(PV-BC) is induced by synaptic activation of metabotropic glutamate receptor subtype 5 (mGluR5) and mediated by the downregulation of Kv1 channel activity...
  89. pmc Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?
    Talakad G Lohith
    Molecular Imaging Branch, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892 1026, USA
    Mol Autism 4:15. 2013
    ..Recent animal studies suggest that upregulated downstream signaling by metabotropic glutamate receptor 5 (mGluR5) might be an important mechanism for cognitive and behavioral abnormalities associated with ..
  90. pmc Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model
    Branden A Smeester
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, United States
    Eur J Pharmacol 743:48-52. 2014
    ..Recently we reported on a bivalent ligand (MMG22) containing both mu agonist and mGluR5 antagonist pharmacophores that produced potent antinociception in mice with LPS-induced acute inflammatory pain ..
  91. pmc Environmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5
    Emma L Burrows
    Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, Vic, Australia
    Neuropsychopharmacology 40:1947-56. 2015
    ..b>Metabotropic glutamate receptor 5 (mGlu5) has also been implicated in the disorder, and has been shown to physically interact with ..
  92. doi Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization
    Katalin Nógrádi
    Gedeon Richter Plc, Budapest 10, PO Box 27, H 1475, Hungary
    Bioorg Med Chem Lett 25:1724-9. 2015
    ..corporate compound library, and hit-to lead development resulted in thieno[2,3-b]pyridine derivative leads with mGluR5 negative allosteric modulator effects...
  93. doi Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy
    Vincent A Jourdain
    Neuroscience Research Unit, Centre Hospitalier Universitaire de Québec and
    J Neurosurg 123:1383-93. 2015
    ..The authors aimed to investigate the biochemical changes in glutamate receptors in striatal and pallidal regions of the basal ganglia after lesion of the STN in parkinsonian macaque monkeys...
  94. doi Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study
    Tomoteru Yamasaki
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Neurosci 36:375-84. 2016
    ..Group I metabotropic glutamate receptor subtypes 1 and 5 (mGluR1 and mGluR5, respectively) are important targets for investigation in several CNS disorders...
  95. pmc Novel Glutamatergic Treatments for Severe Mood Disorders
    Minkyung Park
    Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD U S A, 20892
    Curr Behav Neurosci Rep 2:198-208. 2015
    ..An oral analogue, NRX-1074, is currently under investigation; and 3) mGluR modulators targeting mGluR5 have demonstrated convincing preclinical results.
  96. doi Metabotropic glutamate receptors as therapeutic targets in Parkinson's disease: An update from the last 5 years of research
    Nadhir Litim
    Neuroscience Research Unit, Centre Hospitalier Universitaire de Quebec, CHUL, Quebec City, Canada Faculty of Pharmacy, Laval University, Quebec City, Canada
    Neuropharmacology . 2016
    ..Inhibition of group I (mGlu1 and mGlu5) receptors with NAMs and activation of group II (mGlu2 and 3 receptors) and group III (mGlu 4, 7 and 8 receptors) ..
  97. doi Structural and molecular determinants regulating mGluR5 surface expression
    Kai Chang
    Receptor Biology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 2C903, Bethesda, MD 20892, USA
    Neuropharmacology . 2016
    ..Group I mGluRs, including mGluR1 and mGluR5, have long intracellular C-terminal tails containing multiple protein binding domains and sites for ..
  98. ncbi Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia
    Craig W Lindsley
    Department of Medicinal Chemistry, Merck Research Laboratories, Merck and Co, PO Box 4, West Point, PA 19486, USA
    Curr Top Med Chem 6:771-85. 2006
    ..e., mglur5)...
  99. doi Interaction of blockers of ionotropic NMDA receptors and metabotropic glutamate receptors in a working memory test in rats
    Y A Novitskaya
    Department of Psychopharmacology, Valdman Institute of Pharmacology, Pavlov St Petersburg State Medical University, St Petersburg, Russia
    Neurosci Behav Physiol 40:807-11. 2010
    ..demonstrating tight interactions between ionotropic NMDA receptors and subtype 5 metabotropic glutamate receptors (mGlu5) have shown that blockade of mGlu5 receptors increases the behavioral effects of NMDA receptor antagonists...
  100. doi Endogenous hippocampal LTD that is enabled by spatial object recognition requires activation of NMDA receptors and the metabotropic glutamate receptor, mGlu5
    Jinzhong Jeremy Goh
    Department of Neurophysiology, Ruhr University Bochum, Bochum, Germany
    Hippocampus 23:129-38. 2013
    ..acid (CPP), or antagonism of metabotropic glutamate (mGlu) receptor, mGlu5, using 2-methyl-6-(phenylethynyl) pyridine (MPEP), completely prevented LTD under the novel learning conditions...
  101. ncbi Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord
    F J Alvarez
    Department of Anatomy, Wright State University, Dayton, Ohio 45435, USA
    J Comp Neurol 422:464-87. 2000
    ..by a third anti-mGluR1a antibody was competed by a peptide sequence obtained from a homologous region in mGluR5, suggesting possible cross reactivity in fixed tissue. Autonomic neurons did not express mGluR1a immunoreactivity...

Research Grants64

  1. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2010
    ..Group I mGluRs (mGluR1 and mGluR5) have been implicated in seizures and excitotoxicity...
  2. The Role of Intracellular Metabotropic Glutamate Receptor 5 at the Synapse
    CAROLYN ANN PURGERT; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The Role of Intracellular Metabotropic Glutamate Receptor 5 at the Synapse Project Summary By coupling to various intracellular cascades, metabotropic glutamate receptor 5 (mGluR5) plays an important ..
  3. FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPES
    Jeffrey P Conn; Fiscal Year: 2013
    ..The mGluR5 subtype of mGluR regulates NMDA receptor currents and both long-term potentiation (LTP) and long- term depression (..
  4. Hui Chen Lu; Fiscal Year: 2015
    ..Using mouse whisker-maps as a model system, we found that metabotropic glutamate receptor 5 (mGluR5) signaling is involved in sculpting the anatomical structures and in regulating synaptic ..
  5. Jelena Radulovic; Fiscal Year: 2016
    ..The glutamatergic and oxytocinergic systems, acting via metabotropic glutamate receptors 5 (mGluR5) and oxytocin receptors (Oxtr), respectively, are potently activated during social interactions and co-regulate ..
  6. HING HUNG HENRY LAI; Fiscal Year: 2016
    ..The role of metabotropic glutamate receptor 5 (mGluR5) in bladder pain Research Proposal: Dr...
  7. Kimberly Huber; Fiscal Year: 2015
    ..Accumulating evidence indicates that the Gq-coupled metabotropic glutamate receptor 5 (mGluR5) is dysfunctional and overactive in the mouse model of FXS, Fmr1 KO mice 26, 28, 29, 34, 56...
  8. PDZ scaffold regulation of astrocytic glutamate receptors and transporters
    Randy A Hall; Fiscal Year: 2012
    ..Astrocytes also express glutamate receptors, specifically the metabotropic glutamate receptor subtypes mGluR3 and mGluR5, which are activated by glutamate and known to regulate glutamate transporter activity...
  9. Targeting Glial mGluR5 in Schizophrenia
    Francesca Cicchetti; Fiscal Year: 2013
    ..Interestingly, recent studies have demonstrated that the glutamatergic metabotropic receptor type 5 (mGluR5) is associated with disrupted sensorimotor gating response and altered psychostimulant-induced locomotor activity...
  10. Role of mGluR5 positive allosteric modulators in schizophrenia
    ALEXIS SHEA HAMMOND; Fiscal Year: 2011
    ..First, a novel class of positive allosteric modulators (PAMs) of mGluR5 will be assessed to test the hypothesis that these compounds are binding to a novel site on the receptor...
  11. A2AR/mGluR5 Antagonist Combination Antiparkinsonian Therapy in MPTP Monkeys
    James Bogenpohl; Fiscal Year: 2010
    ..light as a possible target for such a non-dopaminergic treatment is the metabotropic glutamate receptor subtype 5 (mGluR5)...
  12. Volker Neugebauer; Fiscal Year: 2015
    ..These include metabotropic glutamate receptor mGluR5 to activate mPFC neurons, cannabinoid receptor CB1 to release excessive synaptic inhibition of mPFC neurons, and ..
  13. KAREN L O'MALLEY; Fiscal Year: 2014
    ..Recent studies have shown that the metabotropic glutamate receptor, mGluR5, plays a role in the development and maintenance of chronic pain such that pharmacological antagonism of mGluR5 is ..
  14. Qiang Wang; Fiscal Year: 2016
    ..Recently, we found that synaptic ERK directly binds to group I metabotropic glutamate receptors (mGluR1 and mGluR5) and phosphorylates mGluR5a at a cluster of serine sites in the C-terminal region...
  15. Cell type-specific role of Homer proteins in synaptic plasticity
    Robert C Malenka; Fiscal Year: 2012
    ..will be performed to address the hypothesis that Homers regulate the function of the specific group I mGluR, mGluR5, in an isoform- and cell type-specific manner...
  16. Paul G Mermelstein; Fiscal Year: 2016
    ..ER[unreadable]) localized to the surface membrane of nucleus accumbens neurons activates metabotropic glutamate receptor 5 (mGluR5) signaling...
  17. mGluR5 antagonists for methamphetamine addiction
    M Foster Olive; Fiscal Year: 2012
    ..In recent years, animal studies have demonstrated that the type 5 metabotropic glutamate receptor (mGluR5) is involved in various aspects of experimental addiction...
  18. Amy F T Arnsten; Fiscal Year: 2016
    ..Jeffrey Conn, a world expert in mGluR pharmacology. We will examine how mGluR2/3 and mGluR5 agents influence prefrontal cortical (PFC) physiology and cognition in young vs. aged monkeys...
  19. Joyce Besheer; Fiscal Year: 2015
    ..Emerging evidence shows that metabotropic glutamate receptors, specifically subtype 5 (mGluR5) regulate the interoceptive effects of alcohol...
  20. In Vivo Characterization of mGluR5 Positive Allosteric Modulators
    JERRI MICHELLE ROOK; Fiscal Year: 2012
    ..by applicant): Preclinical and clinical studies suggest that ligands for metabotropic glutamate receptors (mGluR5) have exciting potential for treatment of a wide variety of neurological and psychiatric disorders, including ..
  21. Cheminformatics of Allosteric mGluR Modulation promotes Therapeutic Development
    Jens Meiler; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Selective potentiators of the metabotropic glutamate receptor subtype mGluR5 have exciting potential for development of novel treatment strategies for schizophrenia and other disorders that disrupt ..
  22. Christine DeLorenzo; Fiscal Year: 2014
    ..11C]ABP688), an antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), in humans. A large body of diverse evidence implicates mGluR5 in the pathophysiology of depression...
  23. Angelique Bordey; Fiscal Year: 2014
    ..GCPs) transiently express functional GluK2-containing kainate receptors (KAR) and group I metabotropic glutamate receptor 5 (mGlu5R) in the external germinal layer (EGL) when they exit the cell cycle and extend axons...
  24. Anna Liisa Brownell; Fiscal Year: 2014
    ..We have previously synthesized and radiolabeled several allosteric modulators for group I mGluR5 and characterized them as PET imaging ligands in preclinical studies...
  25. Reisa A Sperling; Fiscal Year: 2016
    ..We will employ a novel PET ligand (18-F-PEB) for the metabotropic glutamate receptor, mGluR5, which has been implicated in both learning and in excitotoxicity, in combination with 11-C-PiB amyloid imaging, ..
  26. The Role of Metabotropic Glutamate Receptor 5 in Bladder Pain
    LARA WILEY CROCK; Fiscal Year: 2012
    ..However, preliminary pharmacologic evidence from our lab indicates that activation of metabotropic glutamate receptor 5 (mGluR5) is important in inflammatory and non-inflammatory bladder pain...
  27. Peter W Kalivas; Fiscal Year: 2016
    ..aim #4 examines the effects of daily NAC on signaling via presynaptic mGluR2/3 and postsynaptic signaling on mGluR5. Moreover, in this aim it will be determined if mGluR agonists and antagonists can promote or inhibit the capacity ..
  28. Jin Y Ro; Fiscal Year: 2014
    ..We have previously shown that peripherally localized NMDA receptor (NMDAR) and metabotropic glutamate receptor 5 (mGluR5) are important components in evoking acute muscle nociception as well as mechanical ..
  29. P Jeffrey Conn; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Selective activators of the mGluR5 subtype metabotropic glutamate receptor (mGluR) have been proposed as a novel approach for treatment of schizophrenia...
  30. The Role of mGluR5 Receptors in Extinction Learning of Alcohol Cues
    Justin T Gass; Fiscal Year: 2012
    ..Preliminary evidence indicates that allosteric modulation of type 5 metabotropic glutamate receptors (mGluR5) can facilitate extinction of alcohol-seeking behavior...
  31. Justin T Gass; Fiscal Year: 2015
    ..Preliminary evidence indicates that allosteric modulation of type 5 metabotropic glutamate receptors (mGluR5) can facilitate extinction of alcohol-seeking behavior...
  32. Mark F Bear; Fiscal Year: 2014
    ..we tested the proposal that many psychiatric and neurological symptoms of FXS result from unchecked activation of mGluR5, a metabotropic glutamate receptor...
  33. Nicole Calakos; Fiscal Year: 2016
    ..mGluRs) drives compulsive-like behaviors in mice, (2) build upon our recent progress of defining a role for mGluR5 dysregulation by determining whether mGluR1 signaling is also dysregulated in mice with OCD-like behaviors, (3) ..
  34. Partial Antagonists of mGluR5 for Treatment of Cocaine Addiction
    Craig Lindsley; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The metabotropic glutamate receptor (mGluR) mGluR5 subtype plays a critical role in regulating the rewarding effects of drugs of abuse and recent studies suggest that selective mGluR5 antagonists may ..
  35. mGluR5 Regulation of METH Reward and Sensorimotor Gating
    AMY HERROLD; Fiscal Year: 2009
    ..Anti-dopamine treatments clearly are not sufficient. The metabotropic glutamate receptor group I subtype 5 (mGluR5) is critically ...
  36. Novel Schizophrenia Therapeutics By Virtual High-Throughput Screening
    Jens Meiler; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Selective potentiators of the metabotropic glutamate receptor subtype mGluR5 have exciting potential for development of novel treatment strategies for schizophrenia and other disorders that disrupt ..
  37. DEVELOPMENT OF PET AND SPECT LIGANDS FOR mGluR5 IMAGING
    Gilles Tamagnan; Fiscal Year: 2003
    The metabotropic glutamate receptor subtype 5 (mGluR5) is implicated in many psychiatric disorders, including schizophrenia, mood and anxiety disorders, and cocaine addition...
  38. DEVELOPMENT OF PET AND SPECT LIGANDS FOR mGluR5 IMAGING
    Gilles Tamagnan; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The metabotropic glutamate receptor subtype 5 (mGluR5) is implicated in many psychiatric disorders, including schizophrenia, mood and anxiety disorders, and cocaine addition...
  39. ROLE OF METABOTROPIC GLUTAMATE RECEPTORS IN PPI
    SUZANNE BRODY; Fiscal Year: 2003
    ..the gene responsible for the expression of a particular mGluR) to investigate the role of the mGluRs, specifically mGluR5, in the modulation of PPI and locomotor behavior...
  40. Metabotropic Receptors: Structure/Function/Regulation
    KAREN O MALLEY; Fiscal Year: 2006
    ..We discovered this phenomena, shown it is due to a homodisulfide between cys129 of two mGlu5 polypeptides, and have demonstrated that, surprisingly, covalent dimerization is not critically essential for ..
  41. Fragile X and Synaptic Plasticity
    Julie C Lauterborn; Fiscal Year: 2012
    ..Pilot studies have shown that treatment with the mGluR5 antagonist MPEP, or with a positive AMPA receptor modulator (ampakine), can restore stable LTP to Fmr1-KO ..
  42. METABOTROPIC GLUTAMATE RECEPTORS IN THE BASAL GANGLIA
    Yoland Smith; Fiscal Year: 2006
    ..The group I mGluRs, which comprises mGluR1 and mGluR5, are mostly expressed postsynaptically and produce slow depolarization through coupling with phospholipase C and ..
  43. Subroto Ghose; Fiscal Year: 2016
    ..In Aim 1, we will characterize expression profiles of genes involved in endocannabinoid signaling including CB1, mGluR5 and their associated proteins...
  44. Oxidative damage to receptor: G-protein coupling in the aged hippocampus
    JOSEPH ALOYSIUS MCQUAIL; Fiscal Year: 2012
    ..M1 muscarinic- and mGluR5 metabotropic glutmate receptor-mediated GTP-binding, a functional measure of receptor coupling, will be ..
  45. Allan I Pack; Fiscal Year: 2016
    ..groups this effect is mediated;the mechanism of action based on a specific hypothesis about interaction with mGLuR5;and how the pathway is altered by aging. Project 03 (A...
  46. Philip S Portoghese; Fiscal Year: 2015
    ..regard, the use of morphine, either with a chemokine receptor antagonist or a metabotropic glutamate-5 receptor (mGluR5) antagonist, are known to increase the efficacy of morphine and prevent the establishment of side effects such as ..
  47. ANDREW FORD SCHEYER; Fiscal Year: 2015
    ..in the NAc during "incubation" in addition to CP-AMPAR accumulation and gain of mGluR1-LTD, including loss of mGluR5-mediated synaptic depression and the development of type 1 cannabinoid receptor (CB1R) supersensitivity...
  48. Effector IEG, Homer and Drug Addiction
    Paul F Worley; Fiscal Year: 2010
    ..determine the cellular distribution of mGluRS expression that is sufficient to restore responses to cocaine in the mGluR5 knock out...
  49. Paul J Kammermeier; Fiscal Year: 2016
    ..the functional and pharmacological effects of interactions between two glutamate-activated GPCRs called mGluR1 and mGluR5, which are known to form homodimeric complexes (mGluR1-mGluR1 and mGluR5-mGluR5 dimers), are involved in many ..
  50. ROBERT GEREAU; Fiscal Year: 2014
    ..This pathway is initiated by mGlu5 activation of extracellular signal-regulated kinase (ERK1/2) signaling, leading to phosphorylation of a Kv4...
  51. Deborah A Finn; Fiscal Year: 2014
    ..Binge drinking with the SHAC procedure was decreased by a metabotropic receptor subtype 5 (mGluR5) antagonist, and it upregulated nucleus accumbens (NAc) mGluR5-Homer2-phosphatidylinositol 3-kinase (PI3K) ..
  52. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2011
    ..sites involved in glutamatergic regulation of intravenous nicotine self-administration in rats, by administering mGluR5, NMDA or AMPA/kainate receptor antagonists into the nucleus accumbens shell, the ventral tegmental area, the ..
  53. Mark A Geyer; Fiscal Year: 2015
    ..Aim 3 is to test the hypothesis that metabotropic glutamatergic mGlu2/3 and mGlu5 receptors modulate the behavioral effects of serotonergic hallucinogens, extending recent findings suggesting that ..
  54. ALAN IRA FADEN; Fiscal Year: 2016
    ..Pilot studies in our laboratory have indicated that inflammation may be inhibited by activation of mGluR5 receptors in microglia...
  55. David J Linden; Fiscal Year: 2015
    ..Glutamate also acts upon postsynaptic mGluRs, particularly mGluR1 and mGluR5. Activation of mGluR1/5 stimulates phospholipase C2 and triggers a slow EPSC mediated by TrpC cation channels...
  56. Control of Ethanol Intake by an mGluR5-PKCe Pathway
    M Foster Olive; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This is a competitive renewal application focused on the role of the mGluR5-PKC5 signaling pathway in ethanol self-administration and reinstatement of ethanol-seeking behavior...
  57. Karen Kathleen Szumlinski; Fiscal Year: 2014
    ..A significant body of functional data from my laboratory demonstrates that alcohol-induced increases in mGluR5/Homer2 pathway activity (via PI3K and PKC[unreadable]) within the nucleus accumbens (NAC) shell as important for ..
  58. [18F]FPEB Studies of the mGluR5 Receptor and Methamphetamine Abuse
    ROBERT MICHAEL KESSLER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The mGluR5 receptor is a Type I metabotropic glutamatergic receptor which is critically involved in a number of brain disorders including psychostimulant drug abuse, the Fragile X syndrome, Huntington&..
  59. Irina Esterlis; Fiscal Year: 2015
    ..proposed career training project will provide data on the distribution of the metabotropic glumatamatergic system (mGluR5) in the same BD subjects and will enable a unique investigation of a multi-receptor involvement in BD.
  60. Neurochemical Manipulation of Withdrawal-Induced Drinking
    DEBORAH ANN FINN; Fiscal Year: 2012
    ..Subsequent studies determined that systemic administration of baclofen (GABAB receptor agonist), MPEP (mGluR5 antagonist), and NBI 27914 (CRF1 receptor antagonist) significantly decreased the expression of WID...
  61. Christopher M Olsen; Fiscal Year: 2014
    ..The role of the glutamate mGluR5 receptor in OSS will be examined using novel pharmacological and genetic tools...
  62. Paul F Worley; Fiscal Year: 2016
    ..Aim 4 will examine the link between Shank3[unreadable]C expression and enhanced mGluR5 signaling, and test if inhibition of mGluR5 can reduce the severity of phenotypes...
  63. Mary Eileen Cain; Fiscal Year: 2014
    ..The effect of agonists and antagonists to mGluR2/3, mGluR5, and GLT1on the self-administration of amphetamine in differentially reared rats will be examined...
  64. Athina Markou; Fiscal Year: 2014
    ..transmission, by targeting either the AMPA or metabotropic glutamate 2 (mGlu2) or metabotropic glutamate 5 (mGlu5) receptors, on cue- induced reinstatement of nicotine seeking...