GRIP1

Summary

Gene Symbol: GRIP1
Description: glutamate receptor interacting protein 1
Alias: GRIP, glutamate receptor-interacting protein 1
Species: human

Top Publications

  1. ncbi Blood pressure and isometric exercise. Correlation with anthropometric data and electrolyte urinary excretion in two groups of trained and untrained young men
    G Maiorano
    Istituto di Clinica Medica I, , Italy
    Am J Hypertens 2:65S-69S. 1989
  2. ncbi The effects of exercise on ligamentous stiffness in the wrist
    J J Crisco
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven CT, USA
    J Hand Surg Am 22:44-8. 1997
  3. ncbi Intrinsic balancing in reconstruction of the tetraplegic hand
    C K McCarthy
    Department of Surgery, University of Minnesota School of Medicine, Minneapolis 55455, USA
    J Hand Surg Am 22:596-604. 1997
  4. ncbi Continuous passive motion following metacarpophalangeal joint arthroplasty
    D Ring
    Department of Orthopedics, the Hand Surgery Service, Brigham and Women s Hospital, Boston, MA, USA
    J Hand Surg Am 23:505-11. 1998
  5. ncbi Responsiveness of the short form-36, disability of the arm, shoulder, and hand questionnaire, patient-rated wrist evaluation, and physical impairment measurements in evaluating recovery after a distal radius fracture
    J C MacDermid
    Hand and Upper Limb Centre, St Joseph s Health Centre, London, Ontario, Canada
    J Hand Surg Am 25:330-40. 2000
  6. pmc Surface-scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function
    David Y Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    Mol Endocrinol 21:1381-93. 2007
  7. ncbi Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen
    Dieter Kressler
    Division of Biochemistry, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 282:26897-907. 2007
  8. doi Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase
    Ingvild S Fenne
    Institute of Medicine, Section for Endocrinology, University of Bergen, Bergen, Norway
    Endocrinology 149:4336-45. 2008
  9. pmc Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism
    Rebeca Mejias
    McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, The Howard Hughes Medical Institute, Predoctoral Training Program in Human Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:4920-5. 2011
  10. pmc Gephyrin interacts with the glutamate receptor interacting protein 1 isoforms at GABAergic synapses
    Wendou Yu
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269 3156, USA
    J Neurochem 105:2300-14. 2008

Detail Information

Publications273 found, 100 shown here

  1. ncbi Blood pressure and isometric exercise. Correlation with anthropometric data and electrolyte urinary excretion in two groups of trained and untrained young men
    G Maiorano
    Istituto di Clinica Medica I, , Italy
    Am J Hypertens 2:65S-69S. 1989
    Blood pressure (BP) and heart rate (HR) at rest and at the third minute of hand grip exercise (HG), body weight (W), height (H), body index (BI), triceps skinfold (TS), arm circumference (AC), and 24-hour excretion of Na, K, and ..
  2. ncbi The effects of exercise on ligamentous stiffness in the wrist
    J J Crisco
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven CT, USA
    J Hand Surg Am 22:44-8. 1997
    ..the palmar-dorsal direction in both wrists of 7 healthy volunteers (n = 14) before and after 2 exercise protocols (grip and push-up)...
  3. ncbi Intrinsic balancing in reconstruction of the tetraplegic hand
    C K McCarthy
    Department of Surgery, University of Minnesota School of Medicine, Minneapolis 55455, USA
    J Hand Surg Am 22:596-604. 1997
    ..Patients who underwent reconstructions with intrinsic balancing had more grip strength, by an average of 13-26 N, than those who did not undergo intrinsic balancing...
  4. ncbi Continuous passive motion following metacarpophalangeal joint arthroplasty
    D Ring
    Department of Orthopedics, the Hand Surgery Service, Brigham and Women s Hospital, Boston, MA, USA
    J Hand Surg Am 23:505-11. 1998
    ..Residual ulnar deviation 8 degrees vs 12 degrees and grip strength (2.3 kgf v 3.7 kgf) were both lower in the continuous passive motion cohort...
  5. ncbi Responsiveness of the short form-36, disability of the arm, shoulder, and hand questionnaire, patient-rated wrist evaluation, and physical impairment measurements in evaluating recovery after a distal radius fracture
    J C MacDermid
    Hand and Upper Limb Centre, St Joseph s Health Centre, London, Ontario, Canada
    J Hand Surg Am 25:330-40. 2000
    ..At 3 and 6 months grip strength, range of motion, and dexterity were analyzed...
  6. pmc Surface-scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function
    David Y Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    Mol Endocrinol 21:1381-93. 2007
    ..involves its ability to bind to other coactivators, such as glucocorticoid receptor-interacting protein 1 (GRIP1), as well as its ability to methylate histone H4 and coactivators such as peroxisome proliferator-activated ..
  7. ncbi Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen
    Dieter Kressler
    Division of Biochemistry, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 282:26897-907. 2007
    ..Our findings suggest that tamoxifen-induced changes in the ERalpha LBD promote interactions with the coactivator PGC-1beta, which then cooperates with SRC-1 to enable tamoxifen agonism...
  8. doi Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase
    Ingvild S Fenne
    Institute of Medicine, Section for Endocrinology, University of Bergen, Bergen, Norway
    Endocrinology 149:4336-45. 2008
    Steroid receptor coactivators (SRCs), such as glucocorticoid receptor interacting protein 1 (GRIP1) are recruited to the DNA-bound nuclear receptors (NRs) and are also shown to enhance the gene transactivation by other transcription ..
  9. pmc Gain-of-function glutamate receptor interacting protein 1 variants alter GluA2 recycling and surface distribution in patients with autism
    Rebeca Mejias
    McKusick Nathans Institute of Genetic Medicine and Department of Pediatrics, The Howard Hughes Medical Institute, Predoctoral Training Program in Human Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:4920-5. 2011
    b>Glutamate receptor interacting protein 1 (GRIP1) is a neuronal scaffolding protein that interacts directly with the C termini of glutamate receptors 2/3 (GluA2/3) via its PDZ domains 4 to 6 (PDZ4-6). We found an association (P<0...
  10. pmc Gephyrin interacts with the glutamate receptor interacting protein 1 isoforms at GABAergic synapses
    Wendou Yu
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269 3156, USA
    J Neurochem 105:2300-14. 2008
    We have previously shown that the glutamate receptor interacting protein 1 (GRIP1) splice forms GRIP1a/b and GRIP1c4-7 are present at the GABAergic post-synaptic complex...
  11. ncbi GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex
    B Ye
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 26:603-17. 2000
    The PDZ domain-containing proteins, such as PSD-95 and GRIP, have been suggested to be involved in the targeting of glutamate receptors, a process that plays a critical role in the efficiency of synaptic transmission and plasticity...
  12. ncbi Estrogen receptor activation function 1 works by binding p160 coactivator proteins
    P Webb
    Metabolic Research Unit, University of California School of Medicine, San Francisco 94143 0540, USA
    Mol Endocrinol 12:1605-18. 1998
    ..We propose that the ability of AF-1 and AF-2 to interact with separate surfaces of the same coactivator is important for the ability of these transactivation functions to synergize...
  13. ncbi The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1
    Noora Kotaja
    Biomedicum Helsinki, Institute of Biomedicine, University of Helsinki and Helsinki University Central Hospital, FIN 00014 Helsinki, Finland
    J Biol Chem 277:30283-8. 2002
    ..We have recently shown that the SRC family member GRIP1 interacts with a class of SUMO-1 (small ubiquitin-like modifier 1) E3 ligases, the PIAS proteins, and that the ..
  14. pmc Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells
    Reena Bhandare
    Department of Pharmaceutical Sciences, Thomas Jefferson University, Jefferson School of Pharmacy, 130 South 9th Street, Philadelphia, PA 19107 5233, USA
    Am J Respir Cell Mol Biol 42:9-15. 2010
    ..of GR function by IRF-1 involves its interaction with the transcriptional co-regulator GR-interacting protein 1 (GRIP-1), a known GR transcriptional co-activator...
  15. pmc Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators
    Stephen S Koh
    Department of Pathology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 277:26031-5. 2002
    ..The synergistic coactivator function of beta-catenin and CARM1 is not restricted to steroid receptors because these two coactivators can also act synergistically with another type of DNA binding transcriptional activator, LEF-1/TCF-4...
  16. pmc Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    Mol Cell Biol 22:3621-32. 2002
    ..The p160 coactivators (e.g., SRC-1, GRIP1, and ACTR) bind directly to activated NR and can recruit a variety of secondary coactivators...
  17. pmc Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity
    Young Ho Lee
    Department of Pathology, University of Southern California, Los Angeles, California 90089 9092, USA
    Mol Cell Biol 24:2103-17. 2004
    ..One important coactivator complex includes a p160 coactivator (e.g., GRIP1, SRC-1, or ACTR) that binds directly to activated NR, the histone acetyltransferase p300 or CBP, and the arginine-..
  18. pmc Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination
    Young Ho Lee
    Department of Pathology, University of Southern California, 2011 Zonal Avenue, HMR 301, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 102:3611-6. 2005
    ..synergy of the p160 coactivators [steroid receptor coactivator-1, glucocorticoid receptor interacting protein (GRIP1), or the activator for thyroid hormone and retinoid receptors], the histone acetyltransferases cAMP response ..
  19. doi Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project
    N Perroud
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Pharmacogenomics J 12:68-77. 2012
    ..within genes previously associated with psychiatric phenotypes indirectly linked to suicidal behavior, that is, GRIP1, NXPH1 and ANK3...
  20. ncbi ECOs, FOBs, and UFOs: making sense of observational data
    J F Ross Ross
    The Procter and Gamble Co, Miami Valley Laboratories, Human and Environmental Safety Division, Cincinnati, Ohio 45253 8707, USA
    Toxicol Pathol 28:132-6. 2000
    ..Measurement of forelimb/hind limb grip strength, landing foot splay, and locomotor activity are also required...
  21. ncbi Iliac crest bone grafting and Herbert screw fixation of nonunions of the scaphoid with avascular proximal poles
    R R Robbins
    Department of Orthopaedics, University of Texas Southwestern Medical Center, Dallas, USA
    J Hand Surg Am 20:818-31. 1995
    ..The average range of motion of the wrist did not significantly improve after surgery, but the average grip strength of the injured hand increased by 29 lbs. There were no intraoperative complications...
  22. ncbi Outcome after Colles fracture: the relative responsiveness of three questionnaires and physical examination measures
    P C Amadio
    Department of Orthopedics, Mayo Clinic, Rochester, MN 55905, USA
    J Hand Surg Am 21:781-7. 1996
    ..Impact Measurement Scale (AIMS2), the Brigham and Women's Hospital carpal tunnel questionnaire; pinch strength, grip strength, pressure sensibility, range of motion, and dexterity...
  23. ncbi [Prevention of Lyme borreliosis infection after tick bites]
    K Miyamoto
    Department of Parasitology, Asahikawa Medical College
    Kansenshogaku Zasshi 72:512-6. 1998
    ..Then, the authors recommended that fine tweezers has a firm grip around the mouth part of infested tick and pull out within 24 hours and/or trials to surgical operation for tick ..
  24. ncbi The effects of tendon load and posture on carpal tunnel pressure
    P J Keir
    Department of Kinesiology, University of Waterloo, Ontario, Canada
    J Hand Surg Am 22:628-34. 1997
    ..ulnar) while CTPs were measured under 4 muscle loading conditions with the thumb, index, and long finger in a pinch-grip posture. The first of these was zero load...
  25. ncbi How to study sympatho-vagal balance in arterial hypertension and the effect of antihypertensive drugs?
    B Presciuttini
    Department of Internal Medicine, University Hospital, Verona, Italy
    Acta Cardiol 53:143-52. 1998
    ..Other reflex manoeuvres are hand-grip, cold pressure test, Valsalva manoeuvre, mental arithmetics and microneurography, providing information about the ..
  26. ncbi Wrist arthroplasty with a new generation of prostheses in patients with rheumatoid arthritis
    S Radmer
    Department of Rheumatic Surgery, Immanuel Hospital, Berlin, Germany
    J Hand Surg Am 24:935-43. 1999
    ..At the 18-month follow-up visit, the following parameters were examined: x-ray, grip strength, range of motion, and the patient's subjective satisfaction...
  27. ncbi Anthropometric and health-related fitness characteristics in middle-aged obese women
    T Jurimae
    Institute of Sport Pedagogy, University of Tartu, Estonia
    Coll Antropol 22:97-106. 1998
    ..The following health-related fitness tests used were: dynamic sit-up, hand grip, sit-and-reach, single leg balance and plate tapping...
  28. ncbi Early mobilization following carpal tunnel release. A prospective randomized study
    A C Cook
    Kaiser Permenente, Davis, Sacramento, California, USA
    J Hand Surg Br 20:228-30. 1995
    ..date of return to activities of daily living, dates of return to work at light duty and at full duty, pain level, grip strength, key pinch strength, and occurrence of complications...
  29. ncbi Steindler and pectoralis major flexorplasty: a comparative analysis
    D E Beaton
    Upper Extremity Reconstructive Service, St Michael s Hospital, Toronto, Ontario, Canada
    J Hand Surg Am 20:747-56. 1995
    ..pain, function) and underwent an objective assessment of range of motion, isometric strength, isotonic power, grip, and pinch strength...
  30. ncbi Wide excision of the distal ulna: a multicenter case study
    S W Wolfe
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06520 8071, USA
    J Hand Surg Am 23:222-8. 1998
    ..an average of 22 months after surgery for radiocarpal and radioulnar instability, functional outcome, pain relief, grip strength, and range of motion...
  31. ncbi Comparison of spirapril, isradipine, or combination in hypertensive patients with left ventricular hypertrophy: effects on LVH regression and arrhythmogenic propensity
    A J Manolis
    Tzanio Hospital, Piraeus, Greece
    Am J Hypertens 11:640-8. 1998
    ..effect and spirapril had the least, as assessed by office resting pressures, ambulatory monitoring, and isometric grip testing. There was no correlation between magnitude of blood pressure lowering and degree of LVH regression...
  32. ncbi The Sauvé-Kapandji procedure for osteoarthritis of the distal radioulnar joint
    A Minami
    Department of Othopaedic Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    J Hand Surg Am 20:602-8. 1995
    ..Although all wrists also showed an increased grip strength and improved range of motion over preoperative values, these did not have statistical significance...
  33. ncbi Outcome assessment for carpal tunnel surgery: the relative responsiveness of generic, arthritis-specific, disease-specific, and physical examination measures
    P C Amadio
    Division of Hand Surgery, Mayo Clinic, Rochester, MN 55905, USA
    J Hand Surg Am 21:338-46. 1996
    ..Measurement Scale, the Brigham and Women's Hospital carpal tunnel questionnaire, wrist range of motion, power pinch grip strength, pressure sensibility, and dexterity...
  34. ncbi Wrist arthrodesis using an embedded iliac crest bone graft
    E Lenoble
    Department of Orthopaedic Surgery and Traumatology, , , France
    J Hand Surg Br 18:595-600. 1993
    ..Pronation and supination returned to normal 5 months post-operatively. Grip strength was increased in 80% of the cases. The carpometacarpal joints remained pain-free even when not fused...
  35. ncbi Replantation-revascularization and primary amputation in major hand injuries. Resources spent on treatment and the indirect costs of sick leave in Sweden
    J Holmberg
    Department of Hand Surgery, University Hospital, , Sweden
    J Hand Surg Br 21:576-80. 1996
    ..Mobility, power and performance of a standardized grip test were better for the successfully replanted or revascularized patients...
  36. ncbi Intra-articular fractures of the distal end of the radius treated with an adjustable fixator system
    R M Zanotti
    Section of Orthopaedic Surgery, University of Michigan Hospitals, Ann Arbor 48109 0328, USA
    J Hand Surg Am 22:428-40. 1997
    ..b>Grip strength averaged 80% of the unaffected limb...
  37. ncbi Outcome following nonoperative treatment of displaced distal radius fractures in low-demand patients older than 60 years
    B T Young
    Department of Orthopaedic Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    J Hand Surg Am 25:19-28. 2000
    ..Objective assessment included neuromuscular evaluation and measurements of range of motion and grip strength...
  38. ncbi Degenerative arthritis of the wrist: proximal row carpectomy versus scaphoid excision and four-corner arthrodesis
    M S Cohen
    Hand and Elbow Program, The Department of Orthopaedic Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Hand Surg Am 26:94-104. 2001
    ..b>Grip strength averaged 71% for the PRC group compared with 79% for the 4-corner arthrodesis patients...
  39. ncbi Early results with osseointegrated proximal interphalangeal joint prostheses
    K Moller
    Department of Hand Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    J Hand Surg Am 24:267-74. 1999
    ..satisfaction was high (20 of 22 joints), with significantly improved range of motion and hand function, increased grip strength, good pain relief, and satisfactory appearance...
  40. ncbi Wrist arthrodesis for traumatic conditions: a study of plate and local bone graft application
    A P Weiss
    Department of Orthopaedics, Brown University School of Medicine, Rhode Island Hospital, Providence 02903, USA
    J Hand Surg Am 20:50-6. 1995
    ..The average followup examination period was 2 years. Grip strength, x-ray films, and range of motion were evaluated...
  41. ncbi Factors affecting functional outcome of displaced intra-articular distal radius fractures
    T E Trumble
    Harborview Medical Center, University of Washington School of Medicine, Seattle 98195
    J Hand Surg Am 19:325-40. 1994
    ..b>Grip strength averaged 69 +/- 22% of the contralateral side, and range of motion averaged 75 +/- 18% of the ..
  42. pmc Internal fixation of pilon fractures of the distal radius
    T E Trumble
    Harborview Medical Center, University of Washington School of Medicine, Seattle 98195
    Yale J Biol Med 66:179-91. 1993
    ..01). Grip strength averaged 69% +/- 22% of the contralateral side, and the range of motion averaged 75% +/- 18% of the ..
  43. ncbi Augmentation of distal radius fracture fixation with coralline hydroxyapatite bone graft substitute
    S W Wolfe
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06520 8071, USA
    J Hand Surg Am 24:816-27. 1999
    ..Wrist motion averaged 90% of the uninjured wrist and grip strength measured 75% of the uninjured side...
  44. ncbi Clinical disorders and pressure-pain threshold of the forearm and hand among automobile assembly line workers
    S Bystrom
    Division of Applied Work Physiology, National Institute of Occupational Health, Stockholm, Sweden
    J Hand Surg Br 20:782-90. 1995
    ..The pressure-pain threshold, hand grip force and hand anthropometry were also studied...
  45. ncbi Distal radial metaphyseal forces in an extrinsic grip model: implications for postfracture rehabilitation
    M D Putnam
    Hand Surgical Service, Department of Orthopaedic Surgery, University of Minnesota, Minneapolis 55455, USA
    J Hand Surg Am 25:469-75. 2000
    The purpose of this study was to establish the relationship between force at the distal radius and power grip force of the hand, a common functional and rehabilitation maneuver...
  46. ncbi The value of diagnostic testing in carpal tunnel syndrome
    R M Szabo
    Department of Orthopaedic Surgery, University of California, Davis, Sacramento 95817, USA
    J Hand Surg Am 24:704-14. 1999
    ..b>Grip and pinch strengths were measured...
  47. pmc Multiple receptor interaction domains of GRIP1 function in synergy
    S Schmidt
    , Heinrich-Buff-Ring 58-62, D-35392 Giessen, Germany
    Nucleic Acids Res 26:1191-7. 1998
    ..basal factors of the transcription machinery and/or by recruiting intermediary factors, such as the mouse protein GRIP1. GRIP1 is one of the recently identified coactivators for nuclear hormone receptors...
  48. ncbi Giant cell tumor of the hand: superior results with curettage, cryosurgery, and cementation
    J C Wittig
    Department of Orthopedic Oncology, Washington Cancer Institute at the Washington Hospital Center, Washington, DC 20010, USA
    J Hand Surg Am 26:546-55. 2001
    ..No patient complained of pain. Digital range of motion and grip strength were within normal limits for all 3 patients...
  49. ncbi Noninvasive ambulatory 24 h blood pressures and basal blood pressures predict development of sustained hypertension from a borderline state
    U de Faire
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden
    Am J Hypertens 6:149-55. 1993
    ..4 +/- 7.0 mm Hg, P < .01. They had also somewhat higher BP values during mental arithmetic exercises and hand-grip work (peak DBP 101.1 +/- 8.8 v 96.8 +/- 8.7 mm Hg, P < .05, and 131.4 +/- 14.8 v 123.5 +/- 12.9 mm Hg, P < ...
  50. ncbi Biomechanical changes of cadaveric finger flexion: the effect of wrist position and of the transverse carpal ligament and palmar and forearm fasciae
    H J Kang
    Department of Surgery, University of Chicago, IL 60637, USA
    J Hand Surg Am 21:963-8. 1996
    ..Any increase in the excursion of the flexor tendons could clinically result in decreased grip strength when the wrist is flexed...
  51. ncbi Digital replantation in children: a long-term follow-up study
    G L Cheng
    Department of Hand and Microsurgery, The 401st Hospital of CPLA and The Microsurgery and Hand Surgery Center of CPLA, Qingdao, People s Republic of China
    J Hand Surg Am 23:635-46. 1998
    ..A mean of 19 of 20 preselected activities of daily living could be accomplished. Relative grip strength was 79% that of the normal side and the relative pinch strength was 88%...
  52. ncbi Minimally invasive carpal tunnel decompression using the KnifeLight
    Peter Y K Hwang
    Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore
    Neurosurgery 60:ONS162-8; discussion ONS168-9. 2007
    ....
  53. ncbi Tendon suspension sling arthroplasty for thumb trapeziometacarpal arthritis
    W B Kleinman
    Indiana Hand Center, Indianapolis
    J Hand Surg Am 16:983-91. 1991
    ..At final follow-up, 85% of the patients had minimal symptoms; key pinch and grip strengths measured 76% and 81% of the contralateral uninvolved side, respectively...
  54. ncbi The rationale for and efficacy of surgical intervention for electrodiagnostic-negative cubital tunnel syndrome
    M M Tomaino
    Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Hand Surg Am 26:1077-81. 2001
    ..Paresthesias resolved in all cases, and both elbow range of motion and grip strength returned to normal in 17 of 18 elbows...
  55. ncbi Early dynamic motion versus postoperative immobilization in patients with extensor indicis proprius transfer to restore thumb extension: a prospective randomized study
    G Germann
    Department of Hand, Plastic, and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Germany
    J Hand Surg Am 26:1111-5. 2001
    ..Evaluation included postoperative range of motion, grip strength, duration of treatment, and time off work...
  56. ncbi Scapholunate advanced collapse wrist: proximal row carpectomy or limited wrist arthrodesis with scaphoid excision?
    M M Tomaino
    Department of Orthopaedic Surgery, University of Pittsburgh, PA
    J Hand Surg Am 19:134-42. 1994
    ..5 years postoperatively. At follow-up evaluation, satisfactory pain relief, grip strength, and functional performance were observed except in three patients with PRC, one of whom had developed ..
  57. ncbi Isoelastic arthroplasty of the metacarpophalangeal joints in rheumatoid arthritis: a preliminary report
    J A Vermeiren
    Department of Orthopaedics, Sint Maartenskliniek, Nijmegen, The Netherlands
    J Hand Surg Am 19:319-24. 1994
    ..b>Grip strength improved only slightly...
  58. ncbi Hand function after digital amputation
    S P Chow
    Hong Kong Society for Surgery of the Hand
    J Hand Surg Br 18:125-8. 1993
    ..Although pronation and supination improved to 70% only a few months after injury, it took a year for power grip and key pinch to regain 70%...
  59. ncbi Ulnar shortening for triangular fibrocartilage complex tears associated with ulnar positive variance
    A Minami
    Department of Orthopedic Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    J Hand Surg Am 23:904-8. 1998
    ..All patients complained of pain, restricted forearm rotation, and weakness of grip. Arthroscopy was performed in 23 of 25 wrists to assess the status of the TFCC and the degree of the degenerative ..
  60. ncbi The effect of the additional use of grommets in silicone implant arthroplasty of the metacarpophalangeal joints
    K Schmidt
    Department of Orthopaedic Rheumatology, Ruhr University Bochum, St Josef Hospital, Bochum and St Josef Stift, Sendenhorst, Germany
    J Hand Surg Br 24:561-4. 1999
    ..in the clinical outcomes with respect to swelling, correction of ulnar deviation, range of active movement and grip strength...
  61. ncbi Intercarpal arthrodesis for static and dynamic volar intercalated segment instability
    T Trumble
    Department of Orthopaedics, Yale University School of Medicine, Orthopaedic Section, New Haven, CT 06510
    J Hand Surg Am 13:384-90. 1988
    ..The grip strength postoperatively averaged 58 pounds (74% of the normal contralateral side).
  62. ncbi Basal joint arthritis: trapeziectomy with ligament reconstruction and tendon interposition arthroplasty
    R E Lins
    Massachusetts General Hospital, Department of Orthopaedic Surgery, Boston 02114, USA
    J Hand Surg Am 21:202-9. 1996
    ..Significant improvements were noted in web space measurements and in grip and pinch strength determination. X-ray film assessment using the trapezial space ratio averaged 0.33 +/- 0...
  63. ncbi Perilunate dislocation and fracture dislocation: a critical analysis of the volar-dorsal approach
    D G Sotereanos
    Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, PA, USA
    J Hand Surg Am 22:49-56. 1997
    ..Outcome was assessed after an average of 30 months. Results were based on measurements of grip strength, range of motion, radiographs, and patient satisfaction. Patient satisfaction was high in 9 of 11 patients...
  64. ncbi Outcome of avulsion fractures of the ulnar base of the proximal phalanx of the thumb treated nonsurgically
    J E Kuz
    Park Nicollet Hand Clinic, St Louis Park, MN, USA
    J Hand Surg Am 24:275-82. 1999
    ..Of the 20 patients (67%) who agreed to a follow-up examination, key pinch and grip strength were not statistically different between the injured and noninjured sides...
  65. ncbi Volar A1 pulley approach for fixation of avulsion fractures of the base of the proximal phalanx
    K M Kuhn
    Department of Orthopedic Surgery, Division of Hand and Microvascular Surgery, Naval Medical Center San Diego, San Diego, CA, USA
    J Hand Surg Am 26:762-71. 2001
    ..period all patients had full range of motion of the metacarpophalangeal joint, collateral ligament stability, and grip strength of at least 90% of the uninjured hand. No perioperative complications occurred...
  66. ncbi Ultrasonographically assisted carpal tunnel release
    K Nakamichi
    Department of Orthopaedic Surgery, Toranomon Hospital, Tokyo, Japan
    J Hand Surg Am 22:853-62. 1997
    ..group had better outcomes regarding pain, tenderness of the scar, and key-pinch strength at 3, 6, and 13 weeks, and grip strength at 3 and 6 weeks after surgery. The scar was more aesthetic in this group...
  67. ncbi Dorsal perilunate dislocations and fracture-dislocations: questionnaire, clinical, and radiographic evaluation
    K A Hildebrand
    Department of Surgery, University of Calgary, Calgary, Canada
    J Hand Surg Am 25:1069-79. 2000
    ..The average follow-up period was 37 months (range, 13-65 months). Average flexion-extension motion arc and grip strength in the injured wrist were 57% and 73%, respectively, compared with the contralateral wrist...
  68. ncbi The sequelae of reflex sympathetic dystrophy
    A Zyluk
    Department of General and Hand Surgery, Pomeranian Medical University, Szczecin, Poland
    J Hand Surg Br 26:151-4. 2001
    ..loss of movement in the shoulder joint and hand swelling after use, and 78% of patients had significantly reduced grip strength...
  69. ncbi The importance of the pronated grip x-ray view in evaluating ulnar variance
    M M Tomaino
    Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Hand Surg Am 25:352-7. 2000
    ..Such a view may underestimate variance in wrists in which power grip and pronation result in significant proximal migration of the radius...
  70. ncbi Fracture of the hamate hook
    A T Bishop
    Department of Orthopedics, Mayo Clinic, Rochester, MN 55905
    J Hand Surg Am 13:135-9. 1988
    ..Tenderness directly over the hamulus is always present, and grip strength typically is diminished...
  71. ncbi Hand function following Silastic arthroplasty of the metacarpophalangeal joints in the rheumatoid hand
    A G Rothwell
    Hand Unit, Burwood Hospital, Christchurch, New Zealand
    J Hand Surg Br 22:90-3. 1997
    ..Most improvement occurred in functions requiring pinch span or hook grip and could be attributed largely to correction of ulnar drift and the change of metacarpophalangeal arc of motion...
  72. ncbi First metacarpal subsidence during pinch after ligament reconstruction and tendon interposition basal joint arthroplasty of the thumb
    S S Yang
    Department of Orthopedic Surgery, The Lenox Hill Hospital, New York, NY 10021, USA
    J Hand Surg Am 23:879-83. 1998
    ..Tip-to-tip pinch strength improved 17% from the preoperative measurement. Grip strength improved 17% from the preoperative measurement...
  73. ncbi A comparison of metacarpophalangeal joint silastic arthroplasty with or without crossed intrinsic transfer
    J A Pereira
    Department of Plastic Surgery, The Queen Victoria Hospital, East Grinstead, West Sussex, UK
    J Hand Surg Br 26:229-34. 2001
    ..b>Grip strength and pulp to pulp pinch were significantly and comparably improved in both groups...
  74. ncbi Long-term results of cemented Steffee arthroplasty of the thumb metacarpophalangeal joint
    R M McGovern
    Department of Orthopaedic Surgery, Division of Hand and Microsurgery, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    J Hand Surg Am 26:115-22. 2001
    ..Thumb axis length was maintained or increased in 98%. Although there was not a consistent long-term improvement in grip or pinch strength, 87% of the patients reported subjective improvement in strength and function as a result of ..
  75. ncbi Upper limb function after botulinum toxin A treatment in cerebral palsy: two years follow-up of six cases
    Heli Sätilä
    Tampere University Hospital, Tampere, Finland
    Pediatr Rehabil 9:247-58. 2006
    ..measures were spasticity (modified Ashworth, MAS), active and passive range of movement (ROM), grips (pinch, key grip, 3-finger grip, narrow cylinder grip, wide cylinder grip, pen grip and diagonal grip; grasping, releasing; ..
  76. ncbi Proximal row carpectomy: review of rheumatoid and nonrheumatoid wrists
    D C Ferlic
    Department of Orthopedic Surgery, University of Colorado Health Science Center, Denver
    J Hand Surg Am 16:420-4. 1991
    ..Follow-up ranged from 12 to 120 months and included x-ray films and assessment of pain, range of motion, balance, grip strength, and patient satisfaction...
  77. ncbi Scaphoid excision and capitolunate arthrodesis for radioscaphoid arthritis
    D Kirschenbaum
    Department of Orthopaedic Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA
    J Hand Surg Am 18:780-5. 1993
    ..b>Grip strength averaged 25 kg. Presence of an implant had no significant effect on motion or strength...
  78. ncbi Arthroscopic management of partial scapholunate and lunotriquetral injuries of the wrist
    D S Ruch
    Department of Orthopaedic Surgery, Bowman School of Medicine of Wake Forest University, Winston Salem, NC 27157 1070, USA
    J Hand Surg Am 21:412-7. 1996
    ..None of the patients had a statistically significant loss of grip or pinch strength. X-ray films and dynamic examination under fluoroscopy demonstrated no abnormalities...
  79. ncbi Control of grasp stability during pronation and supination movements
    R S Johansson
    Department of Physiology, Umea University, S 90187 Umea, Sweden
    Exp Brain Res 128:20-30. 1999
    ..We investigated the regulation of grip forces used to stabilize an object held by a precision grip between the thumb and index finger when subjects ..
  80. doi Prevalence of malformations of the hip joint and their relationship to sex, groin pain, and risk of osteoarthritis: a population-based survey
    Kasper Kjaerulf Gosvig
    Department of Orthopedic Surgery, Copenhagen University Hospital of Hvidovre, Hvidovre, Denmark
    J Bone Joint Surg Am 92:1162-9. 2010
    ....
  81. ncbi Soft tissue composition, axial bone mineral density, and grip strength in postmenopausal Turkish women with early rheumatoid arthritis: Is lean body mass a predictor of bone mineral density in rheumatoid arthritis?
    Gunsah Sahin
    Mersin University, Faculty of Medicine, Department of PMR, Mersin, Turkey
    Int J Fertil Womens Med 51:70-4. 2006
    To study bone mineral density and body composition in patients with early rheumatoid arthritis to determine the relationship of lean mass, fat mass and hand grip strength to bone mineral density.
  82. ncbi Associations between pain, grip strength, and manual tests in the treatment evaluation of chronic tennis elbow
    Tuomo Pienimaki
    Oulu Regional Institute of Occupational Health, Oulu, Finland
    Clin J Pain 18:164-70. 2002
    The objective was to assess the associations between changes in pain and grip strength and manual tests among patients with chronic tennis elbow.
  83. ncbi The effects of smiling or crying facial expressions on grip strength, measured with a hand dynamometer and the bi-digital O-ring test
    K N Ozerkan
    Department of Sports and Health Sciences, Istanbul University, School of Physical Education and Sports, Turkey
    Acupunct Electrother Res 26:171-86. 2001
    The effects of smiling or crying facial expressions on grip strength and the Bi-Digital O-Ring Test were evaluated in this study. Ten right-handed basketball players (age group 18-28) were included in the study...
  84. ncbi The short-term reliability of grip strength measurement and the effects of posture and grip span
    Tadayoshi Watanabe
    Department of Orthopaedic Surgery, Yamagata Comprehensive Rehabilitation and Education Center, Kaminoyama City, Yamagata, Japan
    J Hand Surg Am 30:603-9. 2005
    Because of the difficulty in verifying the reliability and validity of grip strength there is still no consensus regarding its measurement, particularly short-term reliability...
  85. ncbi Insights into the activation of brain serine racemase by the multi-PDZ domain glutamate receptor interacting protein, divalent cations and ATP
    Florian Baumgart
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, Spain
    FEBS J 274:4561-71. 2007
    ..racemase is also activated by a multi-PSD-95/discs large/ZO-1 (PDZ) domain glutamate receptor interacting protein (GRIP) that is usually coupled to the GluR2/3 subunits of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid Ca(..
  86. doi Circadian variations in the kinematics of handwriting and grip strength
    Isabelle Jasper
    Clinical Neuropsychology Research Group EKN, Clinic for Neuropsychology, Munchen Bogenhausen Hospital, Munich, Germany
    Chronobiol Int 26:576-94. 2009
    ..rhythm during writing tasks of high everyday relevance and analyzed the relationship to the circadian rhythm of grip strength...
  87. doi The immediate effect of orthotic management on grip strength of patients with lateral epicondylosis
    Fahimeh Sadat Jafarian
    Orthotics and Prosthetics Department, Welfare and Rehabilitaion Sciences University, Tehran, Iran
    J Orthop Sports Phys Ther 39:484-9. 2009
    ..Controlled laboratory study using a randomized crossover design...
  88. ncbi Muscle strength and body mass index as long-term predictors of mortality in initially healthy men
    T Rantanen
    Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Gerontol A Biol Sci Med Sci 55:M168-73. 2000
    ..The aim was to assess hand grip strength as a predictor of all-cause mortality within different levels of body mass index (BMI) in initially ..
  89. ncbi Precision grip deficits in cerebellar disorders in man
    S J Fellows
    Neurologische Klinik, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, D 52027, Aachen, Germany
    Clin Neurophysiol 112:1793-802. 2001
    To investigate the effect of a variety of cerebellar pathologies on a functional motor task (lifting an object in a precision grip).
  90. ncbi Effect of a splint on measures of sustained grip exertion under different forearm and wrist postures
    Yuh Chuan Shih
    Graduate Institute of Logistics Management, National Defense University, P O Box 90046 15, Chung Ho, Taipei 235, Taiwan
    Appl Ergon 36:293-9. 2005
    ..with CTS and that splints are gaining popularity as personal protective equipment, the influence of splints on grip performance has not been determined adequately...
  91. ncbi Lower median nerve block impairs precision grip
    Shouchen Dun
    Hand Research Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, E1641 Biomedical Science Tower, 210 Lothrop Street, Pittsburgh, PA 15213, USA
    J Electromyogr Kinesiol 17:348-54. 2007
    The purpose of this study was to investigate precision grip impairment caused by a lower median nerve block at the wrist...
  92. pmc GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors
    H Hong
    Department of Pathology, University of Southern California, Los Angeles 90033, USA
    Mol Cell Biol 17:2735-44. 1997
    ..for steroid hormone receptors resulted in identification of glucocorticoid receptor interacting protein 1 (GRIP1)...
  93. ncbi A study of repeated lateral pinch grip in myotonic dystrophy
    J Nitz
    Department of Physiotherapy, University of Queensland, Australia
    Physiother Res Int 4:1-11. 1999
    ..If no difference was found, a similar response to a physiotherapy exercise programme as seen in normal subjects might be expected...
  94. ncbi Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:2396-405. 2002
    ..One of the p160 proteins (GRIP1) is tethered to the HIV-1 long terminal repeat (LTR) through kappaB-responsive elements, most likely via NF-kappaB,..
  95. ncbi The impact of gender, body dimension and body composition on hand-grip strength in healthy children
    A Sartorio
    Laboratory for Experimental Endocrinological Research, Instituto Auxologico Italiano, IRCCS, Milano
    J Endocrinol Invest 25:431-5. 2002
    Maximum hand-grip (HG) strength, body composition and main anthropometric variables were evaluated in 278 children with normal weight and growth, aged 5-15 yr divided into 3 age groups: group 1, age+/-SD: 7.6+/-0.9 yr 7.6+/-0...
  96. ncbi Effect of cellular environment on the selective activation of the vitamin D receptor by 1alpha,25-dihydroxyvitamin D3 and its analog 1alpha-fluoro-16-ene-20-epi-23-ene-26,27-bishomo-25-hydroxyvitamin D3 (Ro-26-9228)
    Ayesha Ismail
    Department of Endocrine Neoplasia and Hormonal Disorders, Unit 435, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Endocrinol 18:874-87. 2004
    ..Caco-2 cells for their abilities to interact with a p160 coactivator [glucocorticoid receptor-interacting protein (GRIP)] and with retinoid X receptor (RXR) by pull-down assays...
  97. ncbi The effect of menopause on grip and pinch strength: results from the Chicago, Illinois, site of the Study of Women's Health Across the Nation
    Lianne M Kurina
    Department of Health Studies, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637 1470, USA
    Am J Epidemiol 160:484-91. 2004
    ..the effects of menopausal status, age, race, and use of hormone replacement therapy (HRT) on 3-year changes in grip and pinch strength...
  98. ncbi GRIP1 in GABAergic synapses
    Rong Wen Li
    Department of Physiology and Neurobiology, University of Connecticut at Storrs, 06269, USA
    J Comp Neurol 488:11-27. 2005
    The glutamate receptor-interacting protein GRIP1 is present in glutamatergic synapses and interacts with the GluR2/3/4c subunits of the AMPA receptors...
  99. doi In vivo bite and grip forces, morphology and prey-killing behavior of North American accipiters (Accipitridae) and falcons (Falconidae)
    Diego Sustaita
    Department of Biology, California State University, Northridge, CA 91330 8303, USA
    J Exp Biol 213:2617-28. 2010
    ..Thus, bite and grip forces are ecologically important variables that have direct survival implications...
  100. ncbi Threshold position control of arm movement with anticipatory increase in grip force
    Jean François Pilon
    Department of Physiology, Neurological Science Research Center, Institute of Biomedical Engineering, University of Montreal, Montreal, QC, Canada
    Exp Brain Res 181:49-67. 2007
    The grip force holding an object between fingers usually increases before or simultaneously with arm movement thus preventing the object from sliding...
  101. ncbi Evaluation of the torque-velocity test of the BTE-Primus as a measure of sincerity of effort of grip strength
    Orit Shechtman
    Department of Occupational Therapy, University of Florida, Gainesville, Florida 32610, USA
    J Hand Ther 20:326-34; quiz 335. 2007
    ..study was to examine if differences exist in the linear torque-velocity relationship between maximal and submaximal grip strength effort...

Research Grants72

  1. Jennifer A Nichols; Fiscal Year: 2014
    ..However, current surgical treatments permanently decrease wrist range of motion and grip strength...
  2. ARTIFICIAL HAND FOR LIMB DEFICIENT CHILDREN, 2-8 YRS OLD
    ERNEST MEADOWS; Fiscal Year: 1999
    ..The major distinctions of this hand design are that it is cable and harness- free, and that it has a positive grip unrelated to the strength of the child, unlike the other devices now on the market...
  3. Interhemispheric transfer of grasp control after stroke
    Preeti Raghavan; Fiscal Year: 2010
    ..Psychophysical methods using a grip instrument will be used to examine the type of information necessary for planning of grasp, and quantitative ..
  4. Neural-Enabled Prosthesis with Sensorimotor Integration
    Ranu Jung; Fiscal Year: 2011
    ..implantable neural stimulation technology in a novel manner to elicit meaningful sensations of hand opening and grip force...
  5. NEURAL CONTROL OF MUSCLE ACTIVITY
    Eberhard E Fetz; Fiscal Year: 2012
    ..to forelimb motoneurons) and multiple muscles will be documented during multidirectional wrist movements and grip. This repertoire of movements will activate muscles in different synergistic combinations and test the degree to ..
  6. A Music-Based Rehabilitation Device for Training and Assessing Hand Function
    Nizan Friedman; Fiscal Year: 2012
    ..that the MusicGlove accurately measures clinical hand impairment level, inspires people to make over 1400 practice grip movements in 40 minute training sessions, and induces clinically significant improvements in hand function...
  7. Visual Augmentation Through Virtual Reality to Rehabiliate the Hand after Stroke
    Eugene Tunik; Fiscal Year: 2013
    ..Research project: Reinstating hand function (finger individuation, precision grip, &force production) is most daunting and least addressed after stroke...
  8. Biomimetic Tactile Sensor for Prosthetics
    NICHOLAS WETTELS; Fiscal Year: 2011
    ..Neurophysiologists have identified that rapid reflexive adjustment of grip is essential for handling objects and depends on tactile feedback via the spinal cord...
  9. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..status, and quality of life (Specific Aim #3: life space mobility, Short Physical Performance Battery, leg and hand grip strength, Short Form-36 Health Related Quality of Life, Impact of Weight on Quality of Life-Lite)...
  10. Clinical Significance of Short-term Change and Variability of Grip Strength
    Qian Li Xue; Fiscal Year: 2013
    ..Epidemiologically, muscle weakness defined based on a single measurement of hand grip strength has repeatedly proven to correlate with subsequent adverse health outcomes, even when measured in mid-life ..
  11. Monica A Perez; Fiscal Year: 2016
    ..We focus on bilateral elbow flexion/extension and precision grip, which are basic movements in our daily life activities...
  12. Paul M Macey; Fiscal Year: 2016
    ..heart rate measurements during three autonomic challenges, an inspiratory apnea, Valsalva maneuver, and static hand grip. We will localize the insular cortex subdivisions involved in sympathetic modulation from high-resolution MRI scans...
  13. Obesity, Muscle Strength, and Disability in Older Mexican Americans and Elders fr
    Soham Al Snih; Fiscal Year: 2010
    ..SABE database;4)The association between obesity and ADL disability will be mediated through muscle strength (hand grip strength) in the Hispanic EPESE and each of the six cities included in the SABE database...
  14. The role of CCR5 in HIV-1 Tat and morphine-mediated neurodegeneration.
    Elizabeth M Podhaizer; Fiscal Year: 2013
    ..immunohistochemistry, Golgi-Kopsch impregnation, microscopy, and behavioral assessments of rotarod performance, grip strength, and gait analysis to determine if CCR5 is a good therapeutic candidate to alleviate the consequences of ..
  15. Zong Ming Li; Fiscal Year: 2014
    ..and pathokinetic performance using dexterous manual tasks of thumb opposition, reach-to-pinch, precision grip, and finger pressing...
  16. Increasing Animal Foods in Diets of HIV-Infected Kenyan Women and Their Children
    Judith A Ernst; Fiscal Year: 2011
    ..We will accomplish this aim by comparing bioimpedance (BIA) methodology and hand grip and finger pinch dynamometry measures with arm muscle area calculated from triceps skin fold and mid- arm ..
  17. Intensive Nutrition in ARDS: A Clinical Trial (INTACT)
    Carol L Braunschweig; Fiscal Year: 2012
    ..in fat free mass (measured by dual energy x-ray absorptiometry), weight, muscular weakness (measured as hand grip strength), fatigue (measured as distanced traveled in 6-minute walk assessed at discharge and changes in various ..
  18. Regulation of Force in Children with Prenatal Exposure to Alcohol
    ROGER WILLIAM SIMMONS; Fiscal Year: 2010
    ..One experiment will determine if grip force is excessive and delayed in the alcohol-exposed child, while a second experiment examines the ability to ..
  19. Richard T Moxley; Fiscal Year: 2015
    ..The symptoms of DM1 are widespread. Distal muscle weakness in the arms and legs, along with facial weakness and grip myotonia may occur along with impaired ambulation, unsteadiness on arising from a chair, difficulty with fine ..
  20. Sensorized Neural Prosthetic
    Miguel A L Nicolelis; Fiscal Year: 2010
    ..The experiments will be conducted in rhesus macaques trained to grip objects initially using a virtual-environment arm and then a robotic exoskeleton encasing the monkey's own arm...
  21. Glove and Tool Intervention to Reduce Hand-Arm Vibration
    MARTIN G CHERNIACK; Fiscal Year: 2012
    ..of vibration to the hand can be assessed over a full working day, while accounting for variation in grip and posture, work patterns, recovery, and multiple tools. 2...
  22. Marc H Schieber; Fiscal Year: 2016
    ..actions of the arm and hand are represented in the primary motor and premotor cortex;and 3) to determine how the grip forces and the load forces used in manipulation are represented and controlled...
  23. OMAR EL GHARBAWIE; Fiscal Year: 2014
    ..Each pathway node is further organized into modules that are specific to grip posture (precision and whole hand)...
  24. LEAH ANN KRUBITZER; Fiscal Year: 2015
    ..Cebus monkeys, like humans, have an opposable thumb, utilize a precision grip and engage in a variety of complex manual behaviors...
  25. CUTANEOUS CONTROL OF EXPLORATORY HAND MOVEMENT
    ALLAN SMITH; Fiscal Year: 2001
    ..Prehensile movements of the hand use cutaneous feedback to adjust grip forces to the weight and friction of a handled object to minimize slip on the skin...
  26. Encoding of Reach-to-Grasp in the Primary Motor Cortex
    TIMOTHY EBNER; Fiscal Year: 2006
    ..Second, early investigations into hand movements categorized prehension into two broad classes, power and precision grip and more elaborate classification systems followed...
  27. Virtual reality system for cancer patients'shoulder pain and psychosocial impact
    Grigore C Burdea; Fiscal Year: 2012
    ..These games will automatically adapt to arm range, grip strength and patient level of distress;3) Develop a secure web-accessible database module for game data storage and ..
  28. Evolution of Learned Nonuse in Stroke Hemiparesis
    VICTOR WILLIAM MARK; Fiscal Year: 2012
    ..Concurrent clinical evaluations of coordination, dexterity, tactile sensitivity, grip strength, limb tone, pain, depression, spatial attention, and general stroke impairment will determine whether ..
  29. David E Vaillancourt; Fiscal Year: 2016
    ..imaging (fMRI) to show that the functional activity of all basal ganglia nuclei are reduced in PD during specific grip force switching tasks...
  30. Motor impairments in Huntington's disease: mechanisms and outcome measures
    Ashwini K Rao; Fiscal Year: 2013
    ..the four-year award include specific training in 1) interval timing control, 2) kinetic analysis of precision grip, 3) biostatistics, particularly regression and analysis of longitudinal data, and 4) Neuroepidemiology and clinical ..
  31. David E Vaillancourt; Fiscal Year: 2016
    ..At the same time, we will measure human grip force, eye movements, and brain activation using state-of-the art BOLD fMRI...
  32. The Neurobehavioral Processes of Motor Inhibition
    KRISTINA ANNE NEELY; Fiscal Year: 2012
    ..Neely with a foundation for a career as an independent biomedical research scientist. We will use a novel grip force inhibition paradigm wherein we will simultaneously measure grip force and blood-oxygen-level-dependent (BOLD) ..
  33. Intravenous Protein Therapy for Treatment of Congenital Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..This will include assessment of more disease endpoints including weight gain, lifespan, locomotor activity and grip strength, creatine kinase, apoptosis, and histopathological changes...
  34. Development of novel therapies for aging-induced skeletal muscle atrophy.
    SCOTT MATTHEW EBERT; Fiscal Year: 2013
    ..Compound efficacy will be determined by measuring grip strength, skeletal muscle mass, skeletal muscle fiber size and molecular atrophy mediators...
  35. Biomimetic Tactile Sensor for Prosthetics
    NICHOLAS WETTELS; Fiscal Year: 2009
    ..Neurophysiologists have identified that rapid reflexive adjustment of grip is essential for handling objects and depends on tactile feedback via the spinal cord...
  36. NT-3 gene therapy to improve peripheral nerve function induced by genetic defect
    Zarife Sahenk; Fiscal Year: 2012
    ..Preliminary data using this approach demonstrates promising findings in the TrJ showing improved grip strength and nerve regeneration...
  37. Anti-oxidant treatment of muscle wasting and fatigue in tumor-bearing mice
    YVONNE YUMIKO CLARK; Fiscal Year: 2012
    ..to evaluate muscle wasting and muscle function in tumor-bearing mice, and measures of wheel running activity and grip strength to model behaviors of fatigue and weakness...
  38. NEURONAL FUNCTIONS OF FHFS
    Mitchell Goldfarb; Fiscal Year: 2007
    ..FHF1-/-FHF4 -/- double knockout mice are severely hyperactive and have very poor grip strength. Preliminary electromyography data indicate motor nerve and neuromuscular deficiencies in these animals...
  39. Ken R Smith; Fiscal Year: 2015
    ..sulfate (DHEAS &DHEA), fasting glucose and insulin resistance, telomere length, blood pressure, heart rate, grip strength, forced expiratory volume (FEV1), and BMI...
  40. Md Mizanur Rahman; Fiscal Year: 2014
    ..potential, respiratory rates, and electron transport complex activities to determine muscle activity;analyze grip strength and treadmill endurance capacity to determine muscle strength...
  41. Regulation of NFkappaB activity by the Estrogen Receptor
    Kendall W Nettles; Fiscal Year: 2012
    ..To investigate the importance of CBP and Grip1 in the molecular interactions required for ER-mediated suppression of NF-B, we will measure their recruitment to ..
  42. Francis Perry Wilson; Fiscal Year: 2016
    ..Aim 2: To characterize the within-individual reproducibility and reliability of grip strength dynamometry and bioelectrical impedance analysis (BIA) at the UPenn CRIC site...
  43. DEVELOPMENT OF AN ERGONOMIC MANUAL WHEELCHAIR PUSHRIM
    RONALD BONINGER; Fiscal Year: 2006
    Standard wheelchair handrims are too small to provide an ergonomic grip for the hand, there is no place to rest the thumb, and there are not separate propulsion and braking surfaces...
  44. Dawn Hershman; Fiscal Year: 2015
    ..Assessment of Cancer Therapy-Breast/Endocrine subscale (FACT-B/ES), 3) analgesic use, 4) functional testing (grip strength and [unreadable]timed get up and go[unreadable] for lower extremity[unreadable]) and 5) exploratory ..
  45. Symptomatic Hand OA in Chinese and Caucasians
    Yuqing Zhang; Fiscal Year: 2001
    ..All information, including hand x-ray reading, hand symptoms, grip strength, and functional limitation, has been collected...
  46. Hand Function in Multiple Sclerosis
    Slobodan Jaric; Fiscal Year: 2006
    Poor coordination of hand grip force with external loads during activities of daily living is characteristic of hand function impairment among neurological patients and the elderly...
  47. Transcutaneous vagus nerve stimulation in cerebral ischemia
    Ilknur Ay; Fiscal Year: 2013
    ..and ear tVNS on infarct size (as assessed by vital stain) and motor function (as assessed by behavioral tests and grip strength measurements). To determine their safety, we will monitor physiological parameters (e.g...
  48. Biopsychosocial approaches to healthy aging
    Terrie Vasilopoulos; Fiscal Year: 2012
    ..My proposed project will focus on measures of grip strength, pulmonary function, body mass index, gait, blood pressure, and medication use as indices of physical ..
  49. Treatment for Dysmyelination in PMD and SPG2
    Pamela E Knapp; Fiscal Year: 2013
    ..in transgenic mice that over-express normal PLP, assessing effects on longevity, and using behavioral (rotarod, grip strength) and histological/biochemical outcome measures...
  50. Richard L Huganir; Fiscal Year: 2016
    ..Several of these proteins, including GRIP1 and GRIP2 (Glutamate Receptor Interacting Proteins) and PICK1 (Protein Interactor with C Kinase), specifically ..
  51. Mechanisms of Immunosuppressive Actions of Glucocorticoids
    Inez Rogatsky; Fiscal Year: 2011
    ..Unexpectedly, a yeast 2-hybrid screen for GRIP1 Repression Domain interactors yielded Interferon Regulatory Factor (IRF)3, a key effector of innate immune ..
  52. Lisa Fredman; Fiscal Year: 2014
    ..stress, physical and psychological health status;performance- based measures of physical functioning (timed walk, grip strength, chair stands) and cognitive functioning (Digit Substitution Test and Hopkins Verbal Learning Test)...
  53. DONALD SIMONE; Fiscal Year: 2014
    ..Our preliminary data indicate that mice with SCD exhibit cutaneous (mechanical, heat and cold) and deep (decreased grip force) hyperalgesia similar to that observed in patients with SCD...
  54. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..strength, gait analyses, timed measures of sit-to-rise, functional reach, timed stair climb, timed 40 feet walk and grip/pinch strength measures, b) objective measures of osteoarthritis including x-ray and MRI, c) the SF-36 physical ..
  55. Nicholas M Boulis; Fiscal Year: 2014
    ..SOD1 rats will be evaluated using the grip strength, rotarod, and open field tests to evaluate several aspects of motor function...
  56. Assaying the Anthelmintic Potential of a Novel Flatworm-Specific GPCR Family
    Timothy A Day; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Helminth (worm) parasites maintain a powerful grip on the health and economy of the world...
  57. ELIZABETH MARY VENDITTI; Fiscal Year: 2016
    ..favorable anthropometric (weight, waist), cardio-metabolic (glucose, blood pressure, lipid), physical function (grip strength, balance, gait speed) and health related quality of life outcomes at months 12 and 24...
  58. Ocular and Health Trajectories: The SEE Study
    David J Lee; Fiscal Year: 2012
    ..g., grip strength) and depressive symptoms among SEE participants following adjustment for time-varying ocular conditions, ..
  59. Noreen Goldman; Fiscal Year: 2014
    ..The household protocol of the 2006 biomarker study included measures of grip strength, timed walks, chair stands, blood pressure, and lung capacity...
  60. Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)
    Anne B Newman; Fiscal Year: 2010
    ..cognition), kidney (creatinine), pulmonary (forced vital capacity), metabolic ( fasting glucose), musculoskeletal (grip strength) systems and to rank individuals with the least to greatest multisystem aging...
  61. Discovering Pathways of Functional Decline: A GWAS Approach
    Yongmei Liu; Fiscal Year: 2010
    ..show a strong, graded, and independent association with total mortality and the onset of mobility limitations: grip strength, usual gait speed, IL-6 levels, and forced expiratory volume in 1s (FEV1)...
  62. MICHAEL WILLIAM LAWLOR; Fiscal Year: 2014
    ..studies have shown that treatment of the more severe, Mtm144 mice causes an transient increase in weight, forelimb grip strength, and lifespan...
  63. Biodemography of Health, Social Factors &Life Challenge
    MAXINE A WEINSTEIN; Fiscal Year: 2013
    ..The household protocol of the 2006 biomarker study included measures of grip strength, timed walks, chair stands, blood pressure, and lung capacity...
  64. MRI-Based Modeling to Evaluate Surgical Efficacy for Reduced OA Risk
    Kenneth J Fischer; Fiscal Year: 2012
    ..These subjects will undergo screening for MRI safety and evaluation of pain level and grip strength prior to each MRI scanning session...
  65. Biomechanical Effects of Industrial Eccentric Exertions
    Robert Radwin; Fiscal Year: 2004
    ..resist forearm supination against a motor for simulating eccentric exertion levels representative of pistol grip power hand tool operation. Peak torque levels and build-up time will be experimentally controlled...
  66. Fetal Ethanol Effects on the Peripheral Nervous System
    Mary Johnson; Fiscal Year: 2004
    ..We have preliminary data that exposure of pregnant rats to ethanol results in reduced grip strength in female offspring...
  67. Wrist Flexion to Identify Carpal Tunnel Syndrome
    ROBERT TUCKETT; Fiscal Year: 2001
    ..initial stages, CTS often involves inflammation of tendons transversing the wrist that control finger movement and grip. As tendinitis progresses, there is a constellation of inflammatory events including swelling, vascular stasis, and ..
  68. PATHOPHYSIOLOGICAL TISSUE CHANGES IN RAT MODEL OF CTD
    ANN BARR; Fiscal Year: 2000
    ..ability of animals to maintain target repetition rate over time, their success in retrieving food pellets, maximum grip force, and forelimb movement patterns of reaching and grasping during food pellet retrieval...
  69. MUSCULOSKELETAL DISORDER IN AUTOMOBILE MANUFACTURING
    Laura Punnett; Fiscal Year: 2002
    ..Morbidity information is obtained by standardized interview, screening physical examination, grip and pinch strength, vibrometry, and pressure pain threshold testing...
  70. PKC-dependent GluR2 internalization in the spinal cord by persistent pain
    Yuan Xiang Tao; Fiscal Year: 2009
    ..AMPA receptor GluR2 subunit, through its binding to GRIP and PICK1, may function in the synaptic AMPA receptor trafficking that is critical for many forms of neuronal ..
  71. PACIFIC GENETIC EPIDEMIOLOGIC STUDY ON AGING
    J Curb; Fiscal Year: 2002
    ..Utilizing single nucleotide polymorphisms (SNPs) and existing HHP DNA samples linked with phenotypic data on grip strength and other factors measured over 35 years, we will identify 5 high frequency SNPs in each of 6 ..