GPS2

Summary

Gene Symbol: GPS2
Description: G protein pathway suppressor 2
Alias: AMF-1, G protein pathway suppressor 2, GPS-2
Species: human

Top Publications

  1. pmc Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells
    B H Spain
    Department of Biological Chemistry and Molecular Biology Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    Mol Cell Biol 16:6698-706. 1996
  2. pmc G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation
    Xiwen Cheng
    Department of Biochemistry, School of Medicine, Case Western Reserve University, The Case Comprehensive Cancer Center, and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Biol Chem 284:36395-404. 2009
  3. doi GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus
    Tomas Jakobsson
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    Mol Cell 34:510-8. 2009
  4. pmc Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis
    Sabyasachi Sanyal
    Department of Biosciences and Nutrition, Karolinska Institutet, Karolinska University Hospital, S 14157 Huddinge, Sweden
    Proc Natl Acad Sci U S A 104:15665-70. 2007
  5. pmc GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response
    Nicolas Venteclef
    Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, S 14157 Huddinge Stockholm, Sweden
    Genes Dev 24:381-95. 2010
  6. ncbi Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment
    Tai Hsien Lee
    School of Molecular Biosciences and Center for Reproductive Biology, PO Box 644660, Washington State University, Pullman, WA 99164 4660, USA
    DNA Repair (Amst) 5:32-42. 2006
  7. ncbi Identification of interaction partners and substrates of the cyclin A1-CDK2 complex
    Sven Diederichs
    Department of Medicine, Hematology Oncology, University of Munster, D 48129 Munster, Germany
    J Biol Chem 279:33727-41. 2004
  8. pmc AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins
    Y C Peng
    Department of Dermatology, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    J Virol 74:5872-9. 2000
  9. pmc AMF1 (GPS2) modulates p53 transactivation
    Y C Peng
    Department of Dermatology, New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA
    Mol Cell Biol 21:5913-24. 2001
  10. ncbi The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2
    Jinsong Zhang
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Mol Cell 9:611-23. 2002

Research Grants

  1. Role of the NCoR corepressor complex in the development of insulin resistance
    Valentina Perissi; Fiscal Year: 2012
  2. Christopher K Glass; Fiscal Year: 2016

Scientific Experts

  • Diana M Mitrea
  • Peter Walden
  • Ganpati B Jagdale
  • Eugenio Brambilla
  • A Vieira
  • Szymon Zubek
  • Valentina Perissi
  • M Dafne Cardamone
  • Christopher K Glass
  • Nicolas Venteclef
  • Eckardt Treuter
  • Carly T Cederquist
  • Claudia Lentucci
  • Rongrong Fan
  • Michelle Chan
  • Bogdan Tanasa
  • Amine Toubal
  • Tomas Jakobsson
  • Jan Ake Gustafsson
  • Sabyasachi Sanyal
  • Ho Geun Yoon
  • Lijian Yu
  • Shinji Ohki
  • Xiao Dong Huang
  • Marcel Dreer
  • Menon K Divya
  • Hamid D Ismail
  • Devi Thiagarajan
  • HOLLY E JOHNSON
  • Jiawen Huang
  • Chun Guo
  • Patricia Ancel
  • Jinsong Zhang
  • Ji Feng Feng
  • Hailian Bi
  • Anbu Karani Adikesavan
  • Pakkakul Sangsuriya
  • Gad Getz
  • Elaine O'Meara
  • Xiaowen Wang
  • Michael G Rosenfeld
  • Anastasios Damdimopoulos
  • Guodong Xu
  • Malini Natarajan
  • Xiu Fen Liu
  • Y Y Degenhardt
  • Trevor J Pugh
  • Y C Peng
  • Jasmeen Oberoi
  • Saulius Jarmalavicius
  • Sarah E Wyatt
  • Yuta Komoike
  • Anna Ehrlund
  • Knut R Steffensen
  • A C V Krepischi-Santos
  • Xiwen Cheng
  • Lisa Mari Nilsson
  • Donghui Zhang
  • D E Breiding
  • Lulu Farhana
  • James M Holaska
  • Maria Eriksson
  • M Jeyakumar
  • S Walsh
  • Vijayanand Nadella
  • Tai Hsien Lee
  • Sandrine Jayne
  • E J Androphy
  • Matthew J Shipp
  • Sven Diederichs
  • Gloria K Muday
  • Susan K Fried
  • DAVID GUERTIN
  • Vanessa Hayashi
  • Joseph Orofino
  • Mi Jeong Lee
  • Camila Martinez-Calejman
  • Jean Francois Gautier
  • Dukka B Kc
  • Na Liu
  • Tomoyuki Monma
  • Reina Improgo
  • Wei Du
  • Charles Lee
  • Sasidharan Salini
  • Can Rong Lu
  • Parul Benien
  • Saskia van de Poel
  • Stacey M Fernandes
  • Barbara S Nikolajczyk

Detail Information

Publications60

  1. pmc Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells
    B H Spain
    Department of Biological Chemistry and Molecular Biology Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    Mol Cell Biol 16:6698-706. 1996
    We have isolated two novel human cDNAs, gps1-1 and gps2, that suppress lethal G-protein subunit-activating mutations in the pheromone response pathway of the yeast Saccharomyces cerevisiae...
  2. pmc G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation
    Xiwen Cheng
    Department of Biochemistry, School of Medicine, Case Western Reserve University, The Case Comprehensive Cancer Center, and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Biol Chem 284:36395-404. 2009
    We have identified G protein suppressor 2 (GPS2) as a stable component of the SMRT corepressor complexes...
  3. doi GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus
    Tomas Jakobsson
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    Mol Cell 34:510-8. 2009
    ..Here we address this issue in metabolic oxysterol receptor LXR pathways and describe the selective requirement of GPS2 for ABCG1 cholesterol transporter gene transcription and cholesterol efflux from macrophages...
  4. pmc Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis
    Sabyasachi Sanyal
    Department of Biosciences and Nutrition, Karolinska Institutet, Karolinska University Hospital, S 14157 Huddinge, Sweden
    Proc Natl Acad Sci U S A 104:15665-70. 2007
    ..Here we dissect the transcriptional network governing bile acid biosynthesis in human liver by identifying GPS2, a stoichiometric subunit of a conserved corepressor complex, as a differential coregulator of CYP7A1 and CYP8B1 ..
  5. pmc GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response
    Nicolas Venteclef
    Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, S 14157 Huddinge Stockholm, Sweden
    Genes Dev 24:381-95. 2010
    ..Finally, we provide evidence that the metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors ..
  6. ncbi Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment
    Tai Hsien Lee
    School of Molecular Biosciences and Center for Reproductive Biology, PO Box 644660, Washington State University, Pullman, WA 99164 4660, USA
    DNA Repair (Amst) 5:32-42. 2006
    ..basis underlying the roles of these two human MutS proteins, we have identified G-protein pathway suppressor 2 (GPS2) (i.e...
  7. ncbi Identification of interaction partners and substrates of the cyclin A1-CDK2 complex
    Sven Diederichs
    Department of Medicine, Hematology Oncology, University of Munster, D 48129 Munster, Germany
    J Biol Chem 279:33727-41. 2004
    ..Several novel proteins (INCA1, KARCA1, and PROCA1) as well as the known proteins GPS2 (G-protein pathway suppressor 2), Ku70, receptor for activated protein kinase C1/guanine nucleotide-binding protein ..
  8. pmc AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins
    Y C Peng
    Department of Dermatology, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    J Virol 74:5872-9. 2000
    The cellular protein AMF-1 (Gps2) positively modulates gene expression by the papillomavirus E2 protein (D. E. Breiding et al., Mol. Cell. Biol. 17:7208-7219, 1997)...
  9. pmc AMF1 (GPS2) modulates p53 transactivation
    Y C Peng
    Department of Dermatology, New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA
    Mol Cell Biol 21:5913-24. 2001
    ..that the papillomavirus E2 protein binds the nuclear factor AMF1 (also called G-protein pathway suppressor 2 or GPS2) and that their interaction is necessary for transcriptional activation by E2...
  10. ncbi The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2
    Jinsong Zhang
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Mol Cell 9:611-23. 2002
    ..We report here that GPS2, a protein involved in intracellular signaling, is an integral subunit of the N-CoR-HDAC3 complex...
  11. pmc G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator
    Donghui Zhang
    Laboratories of Respiratory Biology and Neurobiology, Office of Clinical Research, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 283:8580-90. 2008
    ..Nine candidate interactors were identified, including GPS2 (G-protein pathway suppressor 2)...
  12. pmc Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery
    Jasmeen Oberoi
    Henry Wellcome Laboratories of Structural Biology, Department of Biochemistry, University of Leicester, Leicester, UK
    Nat Struct Mol Biol 18:177-84. 2011
    ..The core repression complex involves the recruitment of three proteins, HDAC3, GPS2 and TBL1, to a highly conserved repression domain within SMRT and NCoR...
  13. pmc Aldose Reductase Acts as a Selective Derepressor of PPARγ and the Retinoic Acid Receptor
    Devi Thiagarajan
    Diabetes Research Program, Department of Medicine, New York University Langone Medical Center, New York, NY 10016, USA
    Cell Rep 15:181-96. 2016
    ..AR also downregulates expression of nuclear corepressor complex cofactors including Gps2 and Tblr1, thus affecting activity of the nuclear corepressor complex itself...
  14. pmc Functional interaction of a novel cellular protein with the papillomavirus E2 transactivation domain
    D E Breiding
    Department of Dermatology, New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Cell Biol 17:7208-19. 1997
    ..We conclude that interaction with AMF-1 is necessary for the transcriptional activation function of the E2 AD in mammalian cells...
  15. ncbi [Risk Evaluation and Prognostic Prediction of Colorectal Cancer in Elderly Patients Over 80 Years of Age]
    Shinji Ohki
    Dept of Organ Regulatory Surgery, Fukushima Medical University
    Gan To Kagaku Ryoho 43:1532-1534. 2016
    ..Further analysis revealed that patients with GPS 0 or 1 had a significantly higher 5-year survival rate(84.9%)than those with GPS2(38.9%, p <0.05).
  16. ncbi Cryptic disorder: an order-disorder transformation regulates the function of nucleophosmin
    Diana M Mitrea
    St Jude Children s Research Hospital, Department of Structural Biology, Memphis, TN 38103, USA
    Pac Symp Biocomput . 2012
    ..0, SCRATCH, KinasePhos, GPS2.1, PONDR) and molecular mechanics energy calculations, to test the hypothesis that the polymorphic behavior of Npm-..
  17. doi Attenuation of DMBA/croton oil induced mouse skin papilloma by Apodytes dimidiata mediated by its antioxidant and antimutagenic potential
    Menon K Divya
    a Department of Biochemistry, Amala Cancer Research Centre, Amala Nagar Recognized Research Centre University of Calicut, Thrissur, Kerala, India
    Pharm Biol 54:1564-74. 2016
    ..Discussion and conclusion Antioxidant and antimutagenic activities of AMF might have contributed to its anticarcinogenic potential. ..
  18. pmc Interaction of zyxin, a focal adhesion protein, with the e6 protein from human papillomavirus type 6 results in its nuclear translocation
    Y Y Degenhardt
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Virol 75:11791-802. 2001
    ..Cotransfection of E6 from HPV ((6)E6) and zyxin results in the accumulation of zyxin in the nucleus where it can function as a transcriptional activator. (6)E6 can also mobilize endogenous zyxin to the nucleus...
  19. pmc Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue
    Carly T Cederquist
    Department of Biochemistry, Boston University School of Medicine, 72 E Concord St, Boston, MA 02118, USA
    Mol Metab 6:125-137. 2017
    ..The main aim of this study was to provide further insight into the regulatory mechanisms governing the insulin signaling pathway by investigating the role of non-proteolytic ubiquitination in insulin-mediated activation of AKT...
  20. pmc RF-Phos: A Novel General Phosphorylation Site Prediction Tool Based on Random Forest
    Hamid D Ismail
    Department of Computational Science and Engineering, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA
    Biomed Res Int 2016:3281590. 2016
    ..In side-by-side comparisons based on 10-fold cross validation and an independent dataset, RF-Phos 2.0 compares favorably to other popular mammalian phosphosite prediction methods, such as PhosphoSVM, GPS2.1, and Musite.
  21. doi Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes
    Rongrong Fan
    Karolinska Institutet, Department of Biosciences and Nutrition, Huddinge, Sweden
    Nat Med 22:780-91. 2016
    ..Here we demonstrate that a co-repressor complex containing G protein pathway suppressor 2 (GPS2) crucially controls the macrophage epigenome during activation by metabolic stress...
  22. pmc G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma
    Xiao Dong Huang
    Department of General Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China
    Tumour Biol 37:13333-13343. 2016
    ..However, the molecular pathogenesis of this malignancy is still poorly understood. Here, we showed that GPS2 expression was downregulated in LPS and correlated with the prognosis of this disease...
  23. doi Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation
    Lijian Yu
    Department of Medical Oncology, Dana Farber Cancer Institute
    Clin Cancer Res . 2016
    ..We hypothesize that other concomitant genetic abnormalities underlie the clinical heterogeneity of del(17p) CLL...
  24. pmc Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development
    Claudia Lentucci
    Boston University, United States
    J Biol Chem . 2016
    ..Our previous work indicates that G-Protein Suppressor 2 (GPS2) is a multi-functional protein regulating TNFα signaling and lipid metabolism in the adipose tissue through ..
  25. pmc Interaction of NCOR/SMRT Repressor Complexes with Papillomavirus E8^E2C Proteins Inhibits Viral Replication
    Marcel Dreer
    University Hospital Tuebingen, Institute for Medical Virology and Epidemiology of Viral Diseases, Division of Experimental Virology, Tuebingen, Germany
    PLoS Pathog 12:e1005556. 2016
    ..Proteomic analyses identified all NCoR/SMRT corepressor complex components (HDAC3, GPS2, NCoR, SMRT, TBL1 and TBLR1) as co-precipitating host cell proteins for HPV16 and 31 E8^E2C proteins...
  26. doi Knockdown of a novel G-protein pathway suppressor 2 (GPS2) leads to shrimp mortality by exuvial entrapment during ecdysis
    Pakkakul Sangsuriya
    Center of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok 10330, Thailand Center of Excellence for Shrimp Molecular Biology and Biotechnology Centex Shrimp, Mahidol University, Rama VI Rd, Bangkok 10400, Thailand National Center for Genetic Engineering and Biotechnology BIOTEC, National Science and Technology Development Agency, Pathum Thani 12120, Thailand
    Fish Shellfish Immunol 37:46-52. 2014
    A novel G-protein pathway suppressor 2 (GPS2) has been identified from hemocytes of the whiteleg shrimp Penaeus vannamei (Pv) and appears to play a role in ecdysis...
  27. pmc Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor
    Anbu Karani Adikesavan
    Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Mol Cell Biol 34:1246-61. 2014
    ..SMRT bound directly to p53 and was recruited to p53 binding sites within the p21 promoter. Depletion of GPS2 and TBL1, components of the SMRT corepressor complex, but not histone deacetylase 3 (HDAC3) decreased p21-..
  28. pmc Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation
    Jiawen Huang
    From the Biochemistry Department, Boston University School of Medicine, Boston, Massachusetts 02118
    J Biol Chem 290:19044-54. 2015
    b>G protein pathway suppressor 2 (GPS2) is a multifunctional protein involved in the regulation of a number of metabolic organs...
  29. pmc Prognostic significance of Glasgow prognostic score in patients undergoing esophagectomy for esophageal squamous cell carcinoma
    Ji Feng Feng
    Department of Thoracic Surgery, Zhejiang Cancer Hospital, No 38 Guangji Road, Banshan Bridge Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang Province, Hangzhou, China
    Saudi J Gastroenterol 20:48-53. 2014
    ..The aim of this study was to determine whether the GPS is useful for predicting cancer-specific survival (CSS) of patients for esophageal squamous cell carcinoma (ESCC)...
  30. pmc SUMOylation of GPS2 protein regulates its transcription-suppressing function
    Hailian Bi
    School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China
    Mol Biol Cell 25:2499-508. 2014
    G-protein pathway suppressor 2 (GPS2) is a human suppressor of G protein-activated mitogen-activated protein kinase signaling...
  31. pmc GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARγ
    M Dafne Cardamone
    Biochemistry Department, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA
    Cell Rep 8:163-76. 2014
    ..function, of peroxisome proliferator-activator receptor γ (PPARγ) in adipocytes requires G protein suppressor 2 (GPS2) to prime the local chromatin environment via inhibition of the ubiquitin ligase RNF8 and stabilization of the H3K9 ..
  32. doi Identification of an MLL4-GPS2 fusion as an oncogenic driver of undifferentiated spindle cell sarcoma in a child
    Elaine O'Meara
    Cancer Genetics Program, The National Children s Research Centre, Crumlin, Dublin 12, Ireland
    Genes Chromosomes Cancer 53:991-8. 2014
    ..t(17;19)(p13;q13) in a pediatric UDS and have characterized this alteration to show rearrangement of the MLL4 and GPS2 genes, resulting in an in-frame fusion gene MLL4-GPS2, the expression of which promotes anchorage-independent ..
  33. pmc The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor γ requires G protein pathway suppressor 2
    Chun Guo
    From the Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, The Department of Cancer Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
    J Biol Chem 290:3666-79. 2015
    ..Here we show that NCoR acquires the ability to repress active PPARγ-mediated transcription via G protein pathway suppressor 2 (GPS2), a component of the NCoR corepressor complex...
  34. pmc GPS2 is required for the association of NS5A with VAP-A and hepatitis C virus replication
    Guodong Xu
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
    PLoS ONE 8:e78195. 2013
    ..It has been reported that G protein pathway suppressor 2 (GPS2) is a potential NS5A-binding factor, as identified in a yeast two-hybrid screens of human cDNA ..
  35. ncbi A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha
    D Y Jin
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 272:25816-23. 1997
    ..We isolated a novel human cell factor, G-protein pathway suppressor 2 (GPS2), by its ability to bind the HTLV-I oncoprotein, and we show that this factor can potently suppress Tax activation ..
  36. pmc Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription
    Malini Natarajan
    Immunology and Infectious Diseases, Integrated Biosciences Graduate Program, Penn State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 288:25995-6003. 2013
    ..In addition, we identify NCoR1-GPS2-HDAC3 as a NELF-interacting corepressor complex that is associated with repressed HIV long terminal repeats...
  37. pmc SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation
    Amine Toubal
    Institute of Cardiometabolism and Nutrition, Paris, France
    J Clin Invest 123:362-79. 2013
    ..Here, we report that expression of the transcriptional corepressor complex subunits GPS2 and SMRT was significantly reduced in obese adipose tissue, inversely correlated to inflammatory status, and was ..
  38. doi Contribution of a 300 kHz alternating magnetic field on magnetic hyperthermia treatment of HepG2 cells
    Xiaowen Wang
    Institute of Neurological Disorders, Yuquan Hospital, Tsinghua University, Beijing, China
    Bioelectromagnetics 34:95-103. 2013
    ..Also, AMF exposure itself might play a role in MHT, although these observations were made in vitro. These findings suggest a possible presence of an AMF effect during clinical magnetic hyperthermia...
  39. pmc ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells
    Xiu Fen Liu
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e38130. 2012
    ..by yeast two-hybrid and immunoprecipitation assays the triple functional domain protein (TRIO), the G protein pathway suppressor 2 (GPS2), the delta-interacting protein A (DIPA) and the hyaluronan-mediated motility receptor (HMMR) as ..
  40. pmc A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2
    M Dafne Cardamone
    Howard Hughes Medical Institute, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Cell 46:91-104. 2012
    ..Here, we report a critical, nontranscriptional role of GPS2 as a guardian against hyperstimulation of the TNF-α-induced gene program...
  41. pmc Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
    Trevor J Pugh
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 488:106-10. 2012
    ..helicase gene, DDX3X, often concurrent with CTNNB1 mutations, and in the nuclear co-repressor (N-CoR) complex genes GPS2, BCOR and LDB1...
  42. ncbi Functional analysis of zinc finger proteins that bind to the silencer element in the glutathione transferase P gene
    Atsuhiro Tanabe
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Yamada oka, Suita, Japan
    Biol Pharm Bull 25:970-4. 2002
    ..Recently, zinc finger proteins as candidates for SF-C, which binds to GST-P silencer 2 (GPS2), were isolated...
  43. pmc Mutations in the gravity persistence signal loci in Arabidopsis disrupt the perception and/or signal transduction of gravitropic stimuli
    Sarah E Wyatt
    Department of Botany, North Carolina State University, Raleigh 27695 7612, USA
    Plant Physiol 130:1426-35. 2002
    ..gps1-1 did not bend in response to the 4 degrees C gravity stimulus upon return to RT. gps2-1 responded to the 4 degrees C stimulus but bent in the opposite direction...
  44. ncbi Evidence for altered polar and lateral auxin transport in the gravity persistent signal (gps) mutants of Arabidopsis
    Vijayanand Nadella
    Department of Environmental and Plant Biology, Ohio University, 317 Porter Hall, Athens, OH 45701, USA
    Plant Cell Environ 29:682-90. 2006
    ..mutants respond abnormally after the cold gravistimulation: gps1 does not bend when returned to room temperature, gps2 bends the wrong way and gps3 over-responds, curving past the predicted angle...
  45. ncbi Caries-preventive effect of topical amine fluoride in children with high and low salivary levels of mutans streptococci
    E Brambilla
    Department of Pedodontics, School of Dentistry, University of Milan, Italy
    Caries Res 33:423-7. 1999
    ..The participants of the experimental group received application of an AmF 1% F(-) solution twice a year on the enamel surfaces of the first permanent molars for 5 years...
  46. pmc Gps2, a protein partner for human papillomavirus E6 proteins
    Y Y Degenhardt
    Departments of Pharmacology, Columbia University, New York, New York 10032, USA
    J Virol 75:151-60. 2001
    ..A clone that encoded Gps2 interacted with E6 proteins from HPVs of high and low oncogenic risk...
  47. pmc Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1
    Ho Geun Yoon
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    EMBO J 22:1336-46. 2003
    ..Together, our data reveal the roles of HDAC3 and TBL/TBLR1 and provide evidence for the functional importance of histone interaction in repression mediated by SMRT-N-CoR complexes...
  48. ncbi N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso
    Ho Geun Yoon
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 12:723-34. 2003
    ..Thus, our data demonstrate a critical role for a methyl CpG binding protein in mediating DNA methylation-dependent repression and reveal the mechanism by which it represses transcription...
  49. ncbi Effect of titanium tetrafluoride, amine fluoride and fluoride varnish on enamel erosion in vitro
    A Vieira
    Department of Dentistry and Oral Hygiene, Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands
    Caries Res 39:371-9. 2005
    ..The cumulative erosion depth (in mum) after 72 min was: TiF4 gel 1% 8.29 +/- 0.39; TiF4 gel 4% 8.27 +/- 0.55; AmF 1% 8.69 +/- 0.66; AmF 0.25% 8.86 +/- 0.33; FP 3.43 +/- 1.07; FP-blanco 14.86 +/- 1.59 and control 9.77 +/- 0.49...
  50. pmc Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex
    Sandrine Jayne
    Department of Physiological Chemistry, Stratenum STR 3 211, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem J 398:461-7. 2006
    ..Our results show that the SMRT/NCoR-HDAC3 complex is a cofactor of CNOT2-mediated repression and suggest that transcriptional regulation by the Ccr4-Not complex involves regulation of chromatin modification...
  51. ncbi Genetic variation and relationships between isolates and species of the entomopathogenic nematode genus Heterorhabditis deciphered through isozyme profiles
    Ganpati B Jagdale
    Department of Entomology, The Ohio State University, OARDC, Wooster 4469 4096, USA
    J Parasitol 92:509-16. 2006
    ..bacteriophora isolates with the average pairwise distance of 0.1507. GPS2 and GPS3 were the most closely related isolates with the average distance of only 0...
  52. pmc Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor
    Lulu Farhana
    John D Dingell Veterans Affairs Medical Center, 4646 John R Street, Detroit, MI 48201, USA
    Cancer Res 67:318-25. 2007
    ..These results suggest that AHPN/3-Cl-AHPC and their analogues are SHP ligands and their induction of apoptosis is mediated by their binding to the SHP receptor...
  53. ncbi Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity
    M Jeyakumar
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 282:9312-22. 2007
    ..Collectively, our results indicated that DNA-PK promotes the establishment of a repressive chromatin at a TR target promoter by enhancing the HDAC activity of the receptor-bound NCoR/SMRT corepressor complex...
  54. ncbi On the role of NR3A in human NMDA receptors
    Maria Eriksson
    Karolinska Institutet, Division of Neurodegeneration and Neuroinflammation, Department of Neurobiology, Care Sciences and Society, Novum, S 141 86 Huddinge, Sweden
    Physiol Behav 92:54-9. 2007
    ..signaling pathways for NR3A-containing NMDA receptors, we screened for proteins interacting with hNR3A and identified three proteins: plectin, CARP-1 and GPS2. The possible physiological roles of these interactions are discussed.
  55. pmc An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture
    James M Holaska
    Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Biochemistry 46:8897-908. 2007
    ..When expressed in HeLa cells, FLAG-tagged NCoR subunits Gps2, HDAC3, TBLR1, and NCoR each co-immunoprecipitated emerin, validating one putative complex...
  56. ncbi Effects of breed, feeding system, and parity on udder health and milking characteristics
    S Walsh
    Teagasc, Dairy Production Research Centre, Moorepark, Fermoy, Co Cork, Ireland
    J Dairy Sci 90:5767-79. 2007
    ..The differences expressed by the divergent breeds may reflect differences in the past breeding goals among the breeds, namely the inclusion of traits aimed at maintaining or improving udder health...
  57. pmc Constitutional haploinsufficiency of tumor suppressor genes in mentally retarded patients with microdeletions in 17p13.1
    A C V Krepischi-Santos
    Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of Sao Paulo, Sao Paulo, Brazil
    Cytogenet Genome Res 125:1-7. 2009
    ..1. This segment encompasses 18 genes, including 3 involved in cancer, namely KCTD11/REN, DLG4/PSD95, and GPS2. Furthermore, in 2 of the patients, the deletions also included TP53, the most frequently inactivated gene in human ..
  58. doi Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma
    Saulius Jarmalavicius
    Department of Dermatology, Charite Universitatsmedizin Berlin, Humboldt University, Chariteplatz 1, 10117 Berlin, Germany
    FASEB J 24:937-46. 2010
    ..Jarmalavicius, S., Trefzer, U., Walden, P. Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma...
  59. doi A functional analysis of GABARAP on 17p13.1 by knockdown zebrafish
    Yuta Komoike
    International Research and Educational Institute for Integrated Medical Sciences IREIIMS, Tokyo Women s Medical University, Tokyo, Japan
    J Hum Genet 55:155-62. 2010
    ..Among them, DLG4/PSD95, GPS2, GABARAP and KCTD11 have a function in neuronal development...
  60. doi Arbuscular mycorrhizal fungi alter thymol derivative contents of Inula ensifolia L
    Szymon Zubek
    Mycology Unit, Institute of Botany, Jagiellonian University, Lubicz 46, 31 512 Kraków, Poland
    Mycorrhiza 20:497-504. 2010
    ..The mechanisms by which AMF trigger changes in phytochemical concentration in plant tissues and their consequences for practice are discussed...

Research Grants2

  1. Role of the NCoR corepressor complex in the development of insulin resistance
    Valentina Perissi; Fiscal Year: 2012
    b>GPS2 has been recently reported as an intrinsic component of one of the major represser complexes in transcription, the NCoR/SMRT nuclear receptor corepressor complex...
  2. Christopher K Glass; Fiscal Year: 2016
    ..We will capitalize on our recent discoveries of unexpected roles of GPS2 and the nuclear receptor co-repressors NCoR and SMRT in regulation of inflammatory signaling pathways in ..