GPR85

Summary

Gene Symbol: GPR85
Description: G protein-coupled receptor 85
Alias: SREB, SREB2, seven transmembrane helix receptor, super conserved receptor expressed in brain 2
Species: human

Top Publications

  1. doi A novel albumin nanocomplex containing both small interfering RNA and gold nanorods for synergetic anticancer therapy
    Jin Ha Choi
    Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom Ro, Mapo gu, Seoul 121 742, Republic of Korea
    Nanoscale 7:9229-37. 2015
  2. doi Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain
    Toshihiro Yanai
    Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1 5 1 Tenjin cho, Kiryu, Gunma, 376 8515, Japan
    Genes Cells 21:717-27. 2016
  3. pmc Constitutive Activity among Orphan Class-A G Protein Coupled Receptors
    Adam L Martin
    Department of Biological Sciences, Missouri University of Science and Technology, Rolla, MO, United States of America
    PLoS ONE 10:e0138463. 2015
  4. pmc Fungal Morphology, Iron Homeostasis, and Lipid Metabolism Regulated by a GATA Transcription Factor in Blastomyces dermatitidis
    Amber J Marty
    Department of Medicine, University of Wisconsin, Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 11:e1004959. 2015
  5. pmc The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis
    Eriko Fujita-Jimbo
    Department of Pediatrics, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke shi, Tochigi 3290498 Japan Medical Research Center, International University of Welfare and Health, 2600 1 Kitakanemaru, Ohtawara, 3248501 Japan
    Mol Autism 6:17. 2015
  6. doi Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors
    Kavita Kumari Kakarala
    Centre for Biotechnology and Bioinformatics CBB, School of Life Sciences, Jawaharlal Nehru Institute of Advanced Studies JNIAS, 6th Floor, Buddha Bhawan, M G Road, Secunderabad 500003, Andhra Pradesh, India Electronic address
    Mol Phylogenet Evol 74:66-96. 2014
  7. ncbi Gpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex
    S Hellebrand
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Brain Res Gene Expr Patterns 1:13-6. 2001
  8. pmc miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration
    Tiziana Franceschetti
    From the Center for Molecular Medicine and
    J Biol Chem 288:33347-60. 2013
  9. doi Gene trees, species trees, and morphology converge on a similar phylogeny of living gars (Actinopterygii: Holostei: Lepisosteidae), an ancient clade of ray-finned fishes
    Jeremy J Wright
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Phylogenet Evol 63:848-56. 2012
  10. ncbi Proposed nurse educator competencies: development and validation of a model
    Debra Davis
    University of South Alabama College of Nursing, Mobile, 35294, USA
    Nurs Outlook 53:206-11. 2005

Research Grants

  1. Jeffrey E Pessin; Fiscal Year: 2016
  2. LIVER/INTESTINAL METABOLISM OF BILE ACIDS/CHOLESTEROL
    Phillip Hylemon; Fiscal Year: 2006

Scientific Experts

  • Kavita Kumari Kakarala
  • Byung Keun Oh
  • Jeremy J Wright
  • Mitsuyuki Matsumoto
  • Ole K Olstad
  • Gregory M Gauthier
  • Deborah D Garbee
  • C D Hulsey
  • Alexandre G de Brevern
  • Masaki Kamakura
  • Phillip Hylemon
  • Jeffrey E Pessin
  • Toshihiro Yanai
  • Amber J Marty
  • Adam L Martin
  • Jin Ha Choi
  • Eriko Fujita-Jimbo
  • Thomas J Vassas
  • Tiziana Franceschetti
  • Eugenia Radulescu
  • Qian Chen
  • S Hellebrand
  • Masatoshi Yuri
  • Chuanmei You
  • Konstantin E Komolov
  • Junko Ito
  • Edmund Loh
  • P S Tsai
  • Debra Davis
  • So Youn Kim
  • Aya Kurosawa
  • Shigeki Takeda
  • Hiroyuki Osada
  • Tamio Saito
  • Hirokazu Hirai
  • Ayumu Konno
  • Yoshiaki Nikaido
  • Nozomi Nakajima
  • Aimee T Broman
  • Jeong Woo Choi
  • Seung Won Shin
  • Anissa Lounès-Hadj Sahraoui
  • Joel Fontaine
  • Masato Mori
  • Takanori Yamagata
  • Christina Kendziorski
  • Sunduz Keles
  • Soong Ho Um
  • Karin Kojima
  • Robert Zarnowski
  • Sadahiko Iwamoto
  • Michael A Steurer
  • Takashi Momoi
  • Yuko Tanabe
  • Laura M Bond
  • James M Ntambi
  • Teigan G Dwyer
  • Robert S Aronstam
  • Hai Jin Hwang
  • Zhiling Yu
  • Hong Li
  • Mariko Y Momoi
  • Jongrye Jeon
  • Vicki L Ellingrod
  • Kyle J Burghardt
  • Anne M Delany
  • Sun Kyeong Lee
  • Venkata S Mattay
  • Richard E Straub
  • Joseph H Callicott
  • Catherine B Kessler
  • Daniel R Weinberger
  • Stefano Marenco
  • Fabio Sambataro
  • Noah M Walton
  • Katsunori Tajinda
  • Shinichi Miyake
  • Rick Shin
  • Adam K Gross
  • Kouichi Tamura
  • Carrie L Heusner
  • Yuan Zhou
  • Jeffrey H Kogan
  • Keitaro Mori
  • Masashi Hiramoto
  • Fang Wang
  • Tao Dai
  • Shuji Morita
  • Toshio Teramura
  • Hiroyuki Yokota

Detail Information

Publications35

  1. doi A novel albumin nanocomplex containing both small interfering RNA and gold nanorods for synergetic anticancer therapy
    Jin Ha Choi
    Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom Ro, Mapo gu, Seoul 121 742, Republic of Korea
    Nanoscale 7:9229-37. 2015
    ..both Bcl-2-specific small interfering RNA (siRNA) and gold (Au) nanorods (siRNA and rods encapsulated in BSA; SREB) with the aim of developing a targeted breast cancer therapeutic...
  2. doi Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain
    Toshihiro Yanai
    Faculty of Science and Technology, Division of Molecular Science, Gunma University, 1 5 1 Tenjin cho, Kiryu, Gunma, 376 8515, Japan
    Genes Cells 21:717-27. 2016
    ..One of the orphan GPCR subfamilies, Super conserved Receptor Expressed in Brain (SREB), consists of GPR27, GPR85 and GPR173 and is expressed in the central nervous system...
  3. pmc Constitutive Activity among Orphan Class-A G Protein Coupled Receptors
    Adam L Martin
    Department of Biological Sciences, Missouri University of Science and Technology, Rolla, MO, United States of America
    PLoS ONE 10:e0138463. 2015
    ..GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87). Constitutive activity was observed in 75% of the orphan class-A receptors examined (30 of 40)...
  4. pmc Fungal Morphology, Iron Homeostasis, and Lipid Metabolism Regulated by a GATA Transcription Factor in Blastomyces dermatitidis
    Amber J Marty
    Department of Medicine, University of Wisconsin, Madison, Madison, Wisconsin, United States of America
    PLoS Pathog 11:e1004959. 2015
    ..In B. dermatitidis, we identified a GATA transcription factor, SREB, important for the transition to mold...
  5. pmc The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis
    Eriko Fujita-Jimbo
    Department of Pediatrics, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke shi, Tochigi 3290498 Japan Medical Research Center, International University of Welfare and Health, 2600 1 Kitakanemaru, Ohtawara, 3248501 Japan
    Mol Autism 6:17. 2015
    ..In the present study, we focused on GPR85 as a candidate gene for ASD because the C-terminal amino acid sequence of GPR85 [Thr-Cys-Val-Ile (YCVI)] is ..
  6. doi Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors
    Kavita Kumari Kakarala
    Centre for Biotechnology and Bioinformatics CBB, School of Life Sciences, Jawaharlal Nehru Institute of Advanced Studies JNIAS, 6th Floor, Buddha Bhawan, M G Road, Secunderabad 500003, Andhra Pradesh, India Electronic address
    Mol Phylogenet Evol 74:66-96. 2014
    ..GPR18, GPR141 with N-arachidonylglycine; GPR176 with Free fatty acids, GPR10 with Tachykinin & Neuropeptide Y; GPR85 with ATP, ADP & UDP glucose; GPR151 with Galanin; GPR153 and GPR162 with Adrenalin, Noradrenalin; GPR146, ..
  7. ncbi Gpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex
    S Hellebrand
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Brain Res Gene Expr Patterns 1:13-6. 2001
    ..Here we report the expression of Gpr85, a novel member of this gene family during mouse embryonal development and in the adult brain...
  8. pmc miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration
    Tiziana Franceschetti
    From the Center for Molecular Medicine and
    J Biol Chem 288:33347-60. 2013
    ..Moreover, miR-29 targets RNAs associated with the macrophage lineage: Gpr85 (G protein-coupled receptor 85), Nfia (nuclear factor I/A), and Cd93...
  9. doi Gene trees, species trees, and morphology converge on a similar phylogeny of living gars (Actinopterygii: Holostei: Lepisosteidae), an ancient clade of ray-finned fishes
    Jeremy J Wright
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Phylogenet Evol 63:848-56. 2012
    ..of a portion of one mitochondrial (COI) and seven nuclear (ENC1, myh6, plagl2, S7 ribosomal protein intron 1, sreb2, tbr1, and zic1) genes...
  10. ncbi Proposed nurse educator competencies: development and validation of a model
    Debra Davis
    University of South Alabama College of Nursing, Mobile, 35294, USA
    Nurs Outlook 53:206-11. 2005
    ..grows, the Council on Collegiate Education for Nursing, an affiliate of the Southern Regional Education Board (SREB), has developed and validated competencies to guide the preparation of nurse educators...
  11. pmc SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory
    Qian Chen
    CNS, Astellas Research Institute of America LLC, Skokie, IL 60077, USA
    Eur J Neurosci 36:2597-608. 2012
    SREB2/GPR85, a member of the super-conserved receptor expressed in brain (SREB) family, is the most conserved G-protein-coupled receptor in vertebrate evolution...
  12. pmc Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers
    Eugenia Radulescu
    Clinical Brain Disorders Branch, GCAP, IRP, NIMH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 38:341-9. 2013
    Genetic variants in GPR85 (SREB2: rs56080411 and rs56039557) have been associated with risk for schizophrenia...
  13. pmc Pharmacogenomics of sterol synthesis and statin use in schizophrenia subjects treated with antipsychotics
    Thomas J Vassas
    Clinical and Translational Pharmacy, University of Michigan College of Pharmacy, 428 Church Street, Ann Arbor, MI 48109, USA
    Pharmacogenomics 15:61-7. 2014
    ..Antipsychotics potentially upregulate gene expression of a lipid metabolism pathway protein called SREBP via SREB transcription factors (SREBFs)...
  14. doi Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL/6J mice
    Junko Ito
    Departments of Metabolic Disorder Research, Tsukuba Research Institute, Banyu Pharmaceutical, Okubo 3, Tsukuba, Ibaraki 300 2611, Japan
    Cell Tissue Res 338:257-69. 2009
    ..Of 96 oGPCRs with significant mRNA expression in the GI tract, several oGPCRs showed unique expression patterns. GPR85, GPR37, GPR37L1, brain-specific angiogenesis inhibitor (BAI) 1, BAI2, BAI3, and GPRC5B mRNAs were preferentially ..
  15. doi A new financial budgetary system for community health services institutions in China
    Chuanmei You
    Institute of Medical Information and Center for Health Policy and Management, Chinese Academy of Medical Sciences, Beijing, China
    Int J Health Plann Manage 26:436-48. 2011
    The separation of revenue and expenditure budgets (SREB) is a new financial budgetary system that is being implemented in community health services (CHS) institutions in some areas in China...
  16. doi Identification and relative quantitation of an orphan G-protein coupled receptor SREB2 (GPR85) protein in tissue using a linear ion trap mass spectrometer
    Masatoshi Yuri
    Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    J Proteome Res 10:2658-63. 2011
    SREB2 (GPR85) is an orphan G-protein coupled receptor (GPCR) whose function is unknown...
  17. doi Species tree estimation and the historical biogeography of heroine cichlids
    C Darrin Hulsey
    Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, TN 37996, USA
    Mol Phylogenet Evol 58:124-31. 2011
    ..b, Myomesin1, and Wnt7b) in combination with sequence data from seven other gene regions (Nd2, Rag1, Enc1, Sreb2, Ptr, Plagl2, and Zic1) to elucidate the species tree of these cichlids...
  18. pmc SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis
    Gregory M Gauthier
    Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Pathog 6:e1000846. 2010
    ..We found that the GATA transcription factor SREB governs multiple fates in B...
  19. doi Application of surface plasmon resonance spectroscopy to study G-protein coupled receptor signalling
    Konstantin E Komolov
    Biochemistry Group, IBU, University of Oldenburg, Oldenburg, Germany
    Methods Mol Biol 627:249-60. 2010
    The G-protein coupled receptor rhodopsin is a classical example of a seven transmembrane helix receptor; it is photoexcited and transmits this light signal to a G-protein mediated cascade...
  20. doi A trans-acting riboswitch controls expression of the virulence regulator PrfA in Listeria monocytogenes
    Edmund Loh
    Department of Molecular Biology, Umea University, 90187 Umea, Sweden
    Cell 139:770-9. 2009
    ..Here, we demonstrate that two S-adenosylmethionine (SAM) riboswitches, SreA and SreB, can also function in trans and act as noncoding RNAs in Listeria monocytogenes...
  21. ncbi Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain
    C P Chang
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093 0648
    Neuron 11:1187-95. 1993
    ..Alternative splicing events generate a second, relatively abundant gene product expressed in a distinct ontogenic pattern. These findings serve to identify the receptor for an important neuropeptide...
  22. pmc The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia
    Mitsuyuki Matsumoto
    Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki 305 8585, Japan
    Proc Natl Acad Sci U S A 105:6133-8. 2008
    ..b>SREB2 (GPR85) is the most conserved GPCR throughout vertebrate evolution and is expressed abundantly in brain structures ..
  23. doi Factors influencing intent to stay in academia for nursing faculty in the southern United States of America
    Deborah D Garbee
    Louisiana State University Health Sciences Center School of Nursing, USA
    Int J Nurs Educ Scholarsh 5:Article9. 2008
    ..A random cluster sample consisted of 39 schools of nursing in states within the Southern Regional Education Board (SREB). There were 316 responses from 782 potential participants for a response rate of 40.4%...
  24. ncbi Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly
    Masaki Kamakura
    Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    J Pharm Pharmacol 58:1683-9. 2006
    ..epoxidase (SQLE), which is a key enzyme in cholesterol biosynthesis, and sterol regulatory element-binding protein (SREB)-1, which may be a transcriptional factor of SQLE...
  25. pmc Proteomic analysis of human meibomian gland secretions
    P S Tsai
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Br J Ophthalmol 90:372-7. 2006
    ..The authors hypothesise that many of these proteins originate from the meibomian gland. This study's aim was to begin to develop the proteomic methodology to permit the testing of their hypothesis...
  26. ncbi A structural model of a seven-transmembrane helix receptor: the Duffy antigen/receptor for chemokine (DARC)
    A G de Brevern
    Equipe de Bioinformatique Genomique et Moleculaire EBGM, INSERM U 726, Universite Denis Diderot Paris 7, case 7113, 2, place Jussieu, 75251 Paris, France
    Biochim Biophys Acta 1724:288-306. 2005
    ..The chosen structural models encompass most of the biochemical features and reflect the known experimental data. They may be used to analyze functional interaction properties...
  27. ncbi A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 138:58-69. 2005
    SREB is a subfamily of G-protein-coupled receptors, which consists of SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173)...
  28. ncbi SREBP-1c mediates the insulin-dependent hepatic glucokinase expression
    So Youn Kim
    Department of Biochemistry and Molecular Biology, Yonsei University, Seoul, Korea
    J Biol Chem 279:30823-9. 2004
    ..In the present study, we identified two functional SREBP-1c response elements, SREa and SREb, in the rat LGK promoter...
  29. ncbi Molecular heterogeneity in human osteosarcoma demonstrated by enriched mRNAs isolated by directional tag PCR subtraction cloning
    Ole K Olstad
    Department of Medical Biochemistry, Norwegian Radium Hospital, 0310 N Oslo, Norway
    Anticancer Res 23:2201-16. 2003
    ..The known mRNAs are: Ribosomal protein S11, KSP-37, Tethering factor SEC34, FXYD6, Alpha enolase, G-s-alpha, GPR85, DAF, RPL35A, GIF, TAPA-1, ANAPC11, DCI, hsp27, MRPS7 homolog, eIF p110 subunit, DPH2L, HMG-14, FB1 protein, ..
  30. ncbi Cloning and localization of rgpr85 encoding rat G-protein-coupled receptor
    Jongrye Jeon
    Department of Anatomy, College of Medicine, Korea University, 126 1, 5 Ka, Anam Dong, Seongbuk gu, Seoul 136 705, Republic of Korea
    Biochem Biophys Res Commun 298:613-8. 2002
    ..Thus, dynamic regulation of rgpr85 expression suggests an importance of rgpr85-mediated signaling in the development of cerebral cortex and in the KA-induced responses in the adult brain...
  31. ncbi Analysis of the murine phosphoinositide 3-kinase gamma gene
    E Hirsch
    Department of Genetics, Biology and Biochemistry, University of Torino, I 10126, Torino, Italy
    Gene 256:69-81. 2000
    ..PI3Kgamma is activated by betagamma subunits of heterotrimeric G-proteins, which thus link seven transmembrane helix receptor activation to phosphatidylinositol (3,4,5)-trisphosphate production...
  32. ncbi The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31
    S Hellebrand
    Zentrum für Molekulare Neurobiologie, Institut für Entwicklungsneurobiologie, Martinistrasse 52, D 20246, Hamburg, Germany
    Biochim Biophys Acta 1493:269-72. 2000
    A new G-protein coupled receptor, GPR85, was identified in man and mouse, which is completely conserved at the amino acid level...
  33. ncbi An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system
    M Matsumoto
    Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 272:576-82. 2000
    ..designated SREB (Super Conserved Receptor Expressed in Brain), consists of at least three members, termed SREB1, SREB2, and SREB3...
  34. ncbi A novel nuclear factor, SREB, binds to a cis-acting element, SRE, required for inducible expression of the Aspergillus oryzae Taka-amylase A gene in A. nidulans
    S Tani
    Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan
    Mol Gen Genet 263:232-8. 2000
    ..element), was required for the inducible expression of the taaG2 gene, and thus we designated the nuclear factor SREB (SRE binding factor)...
  35. ncbi The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction
    E P Marin
    Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 275:1930-6. 2000
    ..We suggest that the amino terminus of the fourth loop interacts directly with G(t), particularly with Galpha(t), and with other regions of the intracellular surface of rhodopsin to support G(t) binding...

Research Grants2

  1. Jeffrey E Pessin; Fiscal Year: 2016
    ..CKD8 and/or CycC;and 4) analyzing the effect of phosphorylation defective mutations on CDK8/CycC stability, nuclear SREB- 1c stability and lipogenic gene expression...
  2. LIVER/INTESTINAL METABOLISM OF BILE ACIDS/CHOLESTEROL
    Phillip Hylemon; Fiscal Year: 2006
    ..in the SREBP-2 mediated suppression of the CYP8B1 promoter; e) characterize the significance and physiological role SREB-2-mediated suppression of CYP8b1 (Gil); f) determine the role of steroidogenic acute regulatory (StAR) protein and ..