GPR55

Summary

Gene Symbol: GPR55
Description: G protein-coupled receptor 55
Alias: LPIR1, G-protein coupled receptor 55
Species: human

Top Publications

  1. ncbi Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain
    M Sawzdargo
    Department of Pharmacology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada, USA
    Brain Res Mol Brain Res 64:193-8. 1999
  2. ncbi In silico patent searching reveals a new cannabinoid receptor
    David Baker
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    Trends Pharmacol Sci 27:1-4. 2006
  3. ncbi GPR55 as a new cannabinoid receptor: still a long way to prove it
    François Petitet
    Aureus Pharma, 174 Quai de Jemmapes, 75010 Paris, France
    Chem Biol Drug Des 67:252-3. 2006
  4. pmc The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects
    D G Johns
    GlaxoSmithKline, Cardiovascular and Urogenital Center for Excellence in Drug Discovery, Vascular Biology and Thrombosis, King of Prussia, PA 19406, USA
    Br J Pharmacol 152:825-31. 2007
  5. ncbi Identification of GPR55 as a lysophosphatidylinositol receptor
    Saori Oka
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamihara, Kanagawa 229 0195, Japan
    Biochem Biophys Res Commun 362:928-34. 2007
  6. pmc GPR55: a new member of the cannabinoid receptor clan?
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Br J Pharmacol 152:984-6. 2007
  7. pmc The orphan receptor GPR55 is a novel cannabinoid receptor
    E Ryberg
    Department of Lead Generation, AstraZeneca R and D, Molndal, Sweden
    Br J Pharmacol 152:1092-101. 2007
  8. pmc Novel cannabinoid receptors
    A J Brown
    Department of Screening and Compound Profiling, Molecular Discovery Research, GlaxoSmithKline, Essex, UK
    Br J Pharmacol 152:567-75. 2007
  9. pmc GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
    Jane E Lauckner
    Departments of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2699-704. 2008
  10. pmc Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression
    Markus Waldeck-Weiermair
    Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, A8010, Austria
    J Cell Sci 121:1704-17. 2008

Research Grants

  1. Novel CB Receptors
    Nephi Stella; Fiscal Year: 2010
  2. Jenny L Wiley; Fiscal Year: 2016
  3. Cannabinoid Receptors and Novel Antiglaucoma Drugs
    Zhao Hui Song; Fiscal Year: 2010
  4. The regulation of cannabinoid receptors in microglial cells during HIV infection
    CATALIN FILIPEANU; Fiscal Year: 2012
  5. Mary E Abood; Fiscal Year: 2016
  6. Identification of GPR55 cellular expression within hippocampal cells and its phys
    Jeffrey G Edwards; Fiscal Year: 2012
  7. PATRICIA HODAPP REGGIO; Fiscal Year: 2016
  8. Marisela Agudelo; Fiscal Year: 2014
  9. Optimization of High Selectivity Antagonist Hits for the GPR55 Receptor
    PATRICIA HODAPP REGGIO; Fiscal Year: 2013

Scientific Experts

Detail Information

Publications113 found, 100 shown here

  1. ncbi Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain
    M Sawzdargo
    Department of Pharmacology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada, USA
    Brain Res Mol Brain Res 64:193-8. 1999
    ..Here, we report the identification and cloning of two novel human intronless GPCR genes, GPR52, GPR55 and a pseudogene PsiGPR53...
  2. ncbi In silico patent searching reveals a new cannabinoid receptor
    David Baker
    Department of Neuroinflammation, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    Trends Pharmacol Sci 27:1-4. 2006
    ..patents indicate that several cannabinoid receptor ligands also bind to the orphan G-protein-coupled receptor GPR55. This receptor is reported to be expressed in several tissues and might function in lipid or vascular biology...
  3. ncbi GPR55 as a new cannabinoid receptor: still a long way to prove it
    François Petitet
    Aureus Pharma, 174 Quai de Jemmapes, 75010 Paris, France
    Chem Biol Drug Des 67:252-3. 2006
  4. pmc The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects
    D G Johns
    GlaxoSmithKline, Cardiovascular and Urogenital Center for Excellence in Drug Discovery, Vascular Biology and Thrombosis, King of Prussia, PA 19406, USA
    Br J Pharmacol 152:825-31. 2007
    ..Recent reports suggest GPR55 is an atypical cannabinoid receptor, making it a candidate for the vasodilator 'CBx' receptor...
  5. ncbi Identification of GPR55 as a lysophosphatidylinositol receptor
    Saori Oka
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamihara, Kanagawa 229 0195, Japan
    Biochem Biophys Res Commun 362:928-34. 2007
    b>GPR55 is an orphan G protein-coupled receptor. In this study, we explored a possible endogenous ligand for GPR55 using HEK293 cells which expressed GPR55...
  6. pmc GPR55: a new member of the cannabinoid receptor clan?
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Br J Pharmacol 152:984-6. 2007
    ..present convincing in vitro evidence that the orphan GPCR, GPR55, is a cannabinoid receptor...
  7. pmc The orphan receptor GPR55 is a novel cannabinoid receptor
    E Ryberg
    Department of Lead Generation, AstraZeneca R and D, Molndal, Sweden
    Br J Pharmacol 152:1092-101. 2007
    ..Work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in a number of physiological processes...
  8. pmc Novel cannabinoid receptors
    A J Brown
    Department of Screening and Compound Profiling, Molecular Discovery Research, GlaxoSmithKline, Essex, UK
    Br J Pharmacol 152:567-75. 2007
    ..novel cannabinoid receptors; these are GPR119, which has been proposed as a receptor for oleoylethanolamide, and GPR55 which has been proposed as a receptor activated by multiple different cannabinoid ligands...
  9. pmc GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current
    Jane E Lauckner
    Departments of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:2699-704. 2008
    ..Here, we provide further evidence that GPR55, a G protein-coupled receptor, is a cannabinoid receptor...
  10. pmc Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression
    Markus Waldeck-Weiermair
    Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, A8010, Austria
    J Cell Sci 121:1704-17. 2008
    ..were found, which were characterized as cannabinoid 1 receptor (CB1R; CNR1) and G-protein-coupled receptor 55 (GPR55). Both receptors trigger distinct signaling pathways...
  11. doi The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation
    Christopher M Henstridge
    Centre for Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    FASEB J 23:183-93. 2009
    ..LPI) was recently identified as a novel ligand for the orphan G protein-coupled receptor 55 (GPR55)...
  12. doi 2-Arachidonoyl-sn-glycero-3-phosphoinositol: a possible natural ligand for GPR55
    Saori Oka
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamihara, Kanagawa 229 0195, Japan
    J Biochem 145:13-20. 2009
    b>GPR55 is a G protein-coupled receptor. Recently, we obtained evidence that lysophosphatidylinositol (LPI) is a possible endogenous ligand for GPR55...
  13. doi Role of acylethanolamides in the gastrointestinal tract with special reference to food intake and energy balance
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II and Endocannabinoid Research Group, via D Montesano 49, 80131 Naples, Italy
    Best Pract Res Clin Endocrinol Metab 23:33-49. 2009
    ..activated by OEA and, to a less extent, by PEA), and the orphan G-coupled receptors GPR119 (activated by OEA) and GPR55 (activated by PEA and, with lower potency, by AEA and OEA)...
  14. pmc Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay
    Hong Yin
    GPCR Platform, Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    J Biol Chem 284:12328-38. 2009
    ..We screened a large number of newly "deorphaned" receptors (GPR23, GPR92, GPR55, G2A, GPR18, GPR3, GPR6, GPR12, and GPR63) and control receptors against a collection of approximately 400 lipid ..
  15. doi Is GPR55 an anandamide receptor?
    Andrew J Brown
    Department of Screening and Compound Profiling, Molecular Discovery Research, GlaxoSmithKline, New Frontiers Science Park, GlaxoSmithKline, Essex, UK
    Vitam Horm 81:111-37. 2009
    ..Several approaches have suggested that an orphan receptor, GPR55, is a target for anandamide, but the pharmacology of this receptor is such that it cannot be categorically ..
  16. pmc Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands
    Ankur Kapur
    Department of Anatomy and Cell Biology and Center for Substance Abuse Research, Temple University, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 284:29817-27. 2009
    ..Whether the orphan G-protein coupled receptor GPR55 is also a cannabinoid receptor remains unclear as a result of conflicting pharmacological studies...
  17. pmc The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo
    Lauren S Whyte
    Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, United Kingdom
    Proc Natl Acad Sci U S A 106:16511-6. 2009
    b>GPR55 is a G protein-coupled receptor recently shown to be activated by certain cannabinoids and by lysophosphatidylinositol (LPI). However, the physiological role of GPR55 remains unknown...
  18. doi Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells
    Saori Oka
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamihara, Kanagawa 229 0195, Japan
    J Biochem 147:671-8. 2010
    Lysophosphatidylinositol (LPI) is an endogenous ligand for GPR55, a putative novel type of cannabinoid receptor. In this study, we first examined the effects of LPI on p38 mitogen-activated protein kinase in HEK293 cells expressing GPR55...
  19. pmc GPR55 ligands promote receptor coupling to multiple signalling pathways
    Christopher M Henstridge
    Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Br J Pharmacol 160:604-14. 2010
    Although GPR55 is potently activated by the endogenous lysophospholipid, L-alpha-lysophosphatidylinositol (LPI), it is also thought to be sensitive to a number of cannabinoid ligands, including the prototypic CB1 receptor antagonists ..
  20. ncbi GPR55: Current knowledge and future perspectives of a purported "Type-3" cannabinoid receptor
    Alessio Moriconi
    Research Center, L Aquila, Italy
    Curr Med Chem 17:1411-29. 2010
    In the last decade, accumulated evidence highlighted that GPR55 might be activated by several classical cannabinoid ligands, making this orphan receptor the main candidate to be considered as the "third" cannabinoid receptor...
  21. pmc Pharmacological characterization of GPR55, a putative cannabinoid receptor
    Haleli Sharir
    Department of Anatomy and Cell Biology and Center for Substance Abuse Research, Temple University, Philadelphia, PA 19140, USA
    Pharmacol Ther 126:301-13. 2010
    b>GPR55 has recently attracted much attention as another member of the cannabinoid family, potentially explaining physiological effects that are non-CB1/CB2 mediated...
  22. pmc N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
    Douglas McHugh
    The Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    BMC Neurosci 11:44. 2010
    ..Here, we investigate the relationship between NAGly, Abn-CBD, the unidentified 'Abn-CBD' receptor, GPR18, and BV-2 microglial migration...
  23. doi Generation of lysophosphatidylinositol by DDHD domain containing 1 (DDHD1): Possible involvement of phospholipase D/phosphatidic acid in the activation of DDHD1
    Atsushi Yamashita
    Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Sagamihara, Kanagawa 229 0195, Japan
    Biochim Biophys Acta 1801:711-20. 2010
    b>GPR55 is a seven-transmembrane G-protein-coupled receptor that has been proposed as a novel type of cannabinoid receptor. Previously, we identified lysophosphatidylinositol (LPI), in particular 2-arachidonoyl-LPI, as an agonist for GPR55...
  24. ncbi GPR55, a lysophosphatidylinositol receptor with cannabinoid sensitivity?
    Tapio Nevalainen
    School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland
    Curr Top Med Chem 10:799-813. 2010
    ..targets for cannabinoid ligands and recently it has been suggested that the orphan G-protein coupled receptor, GPR55 can be activated by a range of endogenous, plant and synthetic cannabinoids...
  25. doi Functional polymorphism in the GPR55 gene is associated with anorexia nervosa
    Hiroki Ishiguro
    Department of Psychiatry, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Synapse 65:103-8. 2011
    ..This study therefore focused on the receptor, which is called G-protein-coupled receptor 55 (GPR55) that had recently been reported to have binding affinity for endocannabinoids...
  26. pmc A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells
    Lesley A Ford
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Br J Pharmacol 160:762-71. 2010
    ..LPI) are associated with cancer and LPI is a potent, ligand for the G-protein-coupled receptor GPR55. Here we have assessed the modulation of breast cancer cell migration, orientation and polarization by LPI and ..
  27. doi The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK
    C Andradas
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 30:245-52. 2011
    b>GPR55 is an orphan G protein-coupled receptor that may be engaged by some lipid ligands such as lysophosphatidylinositol and cannabinoid-type compounds...
  28. doi The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation
    R Pineiro
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, Inositide Signalling Group, London, UK
    Oncogene 30:142-52. 2011
    Recently, the orphan receptor G protein-coupled receptor 55 (GPR55) has been proposed as a potential cannabinoid receptor, although controversy remains on its physiological roles...
  29. pmc The GPR55 agonist lysophosphatidylinositol acts as an intracellular messenger and bidirectionally modulates Ca2+ -activated large-conductance K+ channels in endothelial cells
    Alexander I Bondarenko
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21 III, Graz, Austria
    Pflugers Arch 461:177-89. 2011
    ..in endothelial cells, acts as an endogenous agonist of the orphan receptor, G protein-coupled receptor 55 (GPR55)...
  30. pmc International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Pharmacol Rev 62:588-631. 2010
    ..orthosteric or allosteric interactions with non-CB(1), non-CB(2) established GPCRs, deorphanized receptors such as GPR55, ligand-gated ion channels, transient receptor potential (TRP) channels, and other ion channels or peroxisome ..
  31. doi Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist
    Andrew J Brown
    Screening and Compound Profiling, Medicines Research Centre, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK
    J Pharmacol Exp Ther 337:236-46. 2011
    b>GPR55 is a G protein-coupled receptor activated by L-α-lysophosphatidylinositol and suggested to have roles in pain signaling, bone morphogenesis, and possibly in vascular endothelial cells...
  32. doi What is the natural ligand of GPR55?
    Toshiaki Okuno
    Department of Medical Biochemistry, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 85823, Japan
    J Biochem 149:495-7. 2011
    b>GPR55 is a seven transmembrane G protein-coupled receptor and was originally identified as a putative third cannabinoid receptor. Recently, lysophosphatidylinositol (LPI) was reported to be a GPR55 ligand...
  33. doi L-α-lysophosphatidylinositol meets GPR55: a deadly relationship
    Ruth A Ross
    Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, UK
    Trends Pharmacol Sci 32:265-9. 2011
    ..It has now been revealed that LPI activates GPR55, a G protein-coupled receptor that couples to G(12/13) and G(q) proteins, which direct oncogenic signalling...
  34. pmc Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor
    Li Huang
    Department of Internal Medicine, Scott and White Hospital, Texas A and M Health Science Center College of Medicine, Temple, USA
    Lab Invest 91:1007-17. 2011
    ..Recently, GPR55 was identified as a putative cannabinoid receptor; therefore, the role of GPR55 in the antiproliferative effects ..
  35. pmc GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils
    Nariman A B Balenga
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, Graz A 8010, Austria
    Cell Res 21:1452-69. 2011
    ..Here, we provide evidence that the recently de-orphanized 7TM/GPCR GPR55 potently modulates CB(2)R-mediated responses...
  36. pmc Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands
    Evangelia Kotsikorou
    Center for Drug Discovery, University of North Carolina, Greensboro, North Carolina 27402, USA
    Biochemistry 50:5633-47. 2011
    ..The orphan receptor GPR55 binds a subset of CB1 and CB2 ligands and has been proposed as a cannabinoid receptor...
  37. doi Minireview: recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55
    Christopher M Henstridge
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest
    Mol Endocrinol 25:1835-48. 2011
    ..Due to its cannabinoid sensitivity, the G protein-coupled receptor 55 (GPR55) was recently proposed as a candidate; however, GPR55 is phylogenetically distinct from the traditional ..
  38. pmc GPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells
    Alexander Bondarenko
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
    Br J Pharmacol 161:308-20. 2010
    ..lysophospholipid lysophosphatidylinositol (LPI) is an endogenous agonist of the G-protein-coupled receptor 55 (GPR55) exhibiting cannabinoid receptor-like properties in endothelial cells...
  39. pmc GPR55 and the vascular receptors for cannabinoids
    C R Hiley
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Br J Pharmacol 152:559-61. 2007
    ..An orphan receptor, GPR55, apparently a cannabinoid receptor, is activated by abn-cbd, but is not the receptor mediating vasorelaxation to ..
  40. pmc Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries
    C J Daly
    Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow, UK
    Br J Pharmacol 159:787-96. 2010
    ..We have now investigated the distribution of alpha-adrenoceptors, beta-adrenoceptors and cannabinoid-like (GPR55) receptors in the mouse arteries.
  41. doi Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies?
    Susanne Oesch
    University Children s Hospital Divisions of Clinical Chemistry and Oncology, University of Zurich, Switzerland
    J Pharm Pharmacol 61:839-53. 2009
    ..In recent years, CB receptor ligands, including Delta(9)-tetrahydrocannabinol, have been proposed as potential anticancer agents...
  42. doi Pharmacological tools in endocannabinoid neurobiology
    Marco Mor
    Dipartimento Farmaceutico, Universita degli Studi di Parma, viale G P Usberti 27 A Campus Universitario, Parma, I 43100, Italy
    Curr Top Behav Neurosci 1:87-110. 2009
    ..Recently, allosteric ligands for CB₁ receptor and selective ligands for GPR55, a newly characterised GPCR, have also been described in the literature...
  43. pmc CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity
    Emmanuel S Onaivi
    Department of Biology, William Paterson University, Wayne, NJ 07470, USA
    J Psychopharmacol 26:92-103. 2012
    There are two well characterized cannabinoid receptors (CBRs), CB1-Rs and CB2-Rs, with other candidates, such as GPR55, PPARs and vanilloid TRPV1 (VR1) receptors, which are either activated by cannabinoids and/or endocannabinoids (eCBs)...
  44. doi Alterations in the endocannabinoid system in the rat valproic acid model of autism
    D M Kerr
    Physiology, School of Medicine, National University of Ireland Galway, Ireland
    Behav Brain Res 249:124-32. 2013
    ..expression was not altered in any of the regions examined, however VPA-exposed rats exhibited reduced PPARα and GPR55 expression in the frontal cortex and PPARγ and GPR55 expression in the hippocampus, additional receptor targets ..
  45. pmc Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55
    Justine Yu
    Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 288:22481-92. 2013
    The L-α-lysophosphatidylinositol (LPI)-sensitive receptor GPR55 is coupled to Ca(2+) signaling. Low levels of GPR55 expression in the heart have been reported...
  46. doi A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo
    Vijayan Gangadharan
    Institute of Pharmacology, Heidelberg University, Heidelberg 69120, Germany
    Pain 154:2801-12. 2013
    ..tools in mice, we delineated receptor-mediated from non-receptor-mediated effects of LPI and we observed that GPR55, which functions as an LPI receptor when heterologously expressed in mammalian cells, only partially mediates LPI-..
  47. pmc Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice
    A M McKillop
    Biomedical Sciences Research Institute, SAAD Centre for Pharmacy and Diabetes, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland
    Br J Pharmacol 170:978-90. 2013
    ..This study assessed the effects of various GPR55 agonists on glucose homeostasis.
  48. pmc Rod photoreceptors express GPR55 in the adult vervet monkey retina
    Joseph Bouskila
    School of Optometry, University of Montreal, Montreal, QC, Canada Biomedical Sciences, Faculty of Medicine, University of Montreal, Montreal, QC, Canada
    PLoS ONE 8:e81080. 2013
    ..In recent years, the G-protein coupled receptor 55 (GPR55) was suggested as a cannabinoid receptor based on its activation by anandamide and tetrahydrocannabinol...
  49. doi Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors
    Monica Imbernon
    Department of Physiology, CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain Ciber Fisiopatología de la Obesidad y Nutrición CIBERobn, Santiago de Compostela 15706, Spain
    Mol Cell Endocrinol 383:159-69. 2014
    The G protein-coupled receptor GPR55 has been proposed as a new cannabinoid receptor associated with obesity in humans...
  50. doi Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature
    Jessica MacIntyre
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2
    Eur J Pharmacol 735:105-14. 2014
    ..These actions of Abn-CBD were independent of CB1/CB2 receptors and were not mediated by agonists for GPR55 or affected by nitric oxide synthase (NOS) inhibition...
  51. doi Central administration of GPR55 receptor agonist and antagonist modulates anxiety-related behaviors in rats
    Abbasali Rahimi
    Department of Biology, Faculty of Basic Sciences, University of Mazandaran, P O Box 13145 784, Babolsar, Iran
    Fundam Clin Pharmacol 29:185-90. 2015
    G-protein-coupled receptor 55 (GPR55) has been proposed as an atypical cannabinoid receptor, which is activated by lysophosphatidylinositols and some synthetic or endogenous cannabinoid molecules...
  52. doi Deletion of G-protein-coupled receptor 55 promotes obesity by reducing physical activity
    A Meadows
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Int J Obes (Lond) 40:417-24. 2016
    ..G-protein-coupled receptor 55 (GPR55) is an atypical cannabinoid receptor, and its pharmacology and functions are distinct from CB1...
  53. doi Role of the lysophosphatidylinositol/GPR55 axis in cancer
    Marco Falasca
    Metabolic Signalling Group, School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, Western Australia 6102, Australia Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Blizard Institute, 4 Newark Street, London E1 2AT, UK Electronic address
    Adv Biol Regul 60:88-93. 2016
    ..It is well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for LPI...
  54. ncbi The emerging role of the cannabinoid receptor family in peripheral and neuro-immune interactions
    Orla Haugh
    School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, The University of Dublin, Ireland
    Curr Drug Targets . 2016
    ..However, putative, novel lipid-sensing CB receptors have recently been identified, including the orphan GPR55 and GPR18 receptors that are regulated by cannabinoid-like molecules and interact with CB system...
  55. pmc Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer
    Clara Andradas
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncotarget 7:47565-47575. 2016
    The orphan G protein-coupled receptor GPR55 has been directly or indirectly related to basic alterations that drive malignant growth: uncontrolled cancer cell proliferation, sustained angiogenesis, and cancer cell adhesion and migration...
  56. pmc Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice
    Cornelius Hess
    Department Forensic Toxicology, Institute of Forensic Medicine, University Hospital of Bonn, Stiftsplatz 12, 53111 Bonn, Germany
    Forensic Toxicol 34:329-343. 2016
    ..Moreover, we investigated the activities of the compounds at the orphan G protein-coupled receptors GPR18 and GPR55 both of which are known to interact with cannabinoids...
  57. doi Cannabinoid receptor ligand bias: implications in the central nervous system
    Robert B Laprairie
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Curr Opin Pharmacol 32:32-43. 2016
    The G protein-coupled cannabinoid receptors CB1, CB2, GPR18, and GPR55 regulate neurotransmission, pain, and inflammation and have been intensively investigated as potential drug targets...
  58. pmc Deletion of Gpr55 Results in Subtle Effects on Energy Metabolism, Motor Activity and Thermal Pain Sensation
    Mikael Bjursell
    Discovery Sciences Transgenics, AstraZeneca R and D, Molndal, Sweden
    PLoS ONE 11:e0167965. 2016
    The G-protein coupled receptor 55 (GPR55) is activated by cannabinoids and non-cannabinoid molecules and has been speculated to play a modulatory role in a large variety of physiological and pathological processes, including in ..
  59. pmc Endocannabinoid-like N-arachidonoyl serine is a novel pro-angiogenic mediator
    X Zhang
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Br J Pharmacol 160:1583-94. 2010
    ..ARA-S induces vasodilatation and shows vasoprotective potential via activation of key signalling pathways in endothelial cells. Based on these findings, the effect of ARA-S on endothelial functions was further studied...
  60. pmc A GPR18-based signalling system regulates IOP in murine eye
    Meggie D Caldwell
    Department of Clinical Vision Science, Dalhousie University, Halifax, NS, Canada
    Br J Pharmacol 169:834-43. 2013
    ..are: (i) to determine the disposition of GPR18 receptors and ligands in anterior murine eye, (ii) examine the effect of GPR18 activation on intraocular pressure (IOP) in a murine model, including knockout mice for CB₁, CB₂ and GPR55.
  61. pmc GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination
    Chia Shan Wu
    The Cain Foundation Laboratories, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e60314. 2013
    The G-protein coupled receptor 55 (GPR55) is activated by lysophosphatidylinositols and some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic/inflammatory pain, cancer and bone physiology...
  62. pmc A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice
    Kun Li
    Snyder Institute for Chronic Diseases, Division of Gastroenterology, Department of Medicine, University of Calgary, Alberta, Canada
    Neuropharmacology 71:255-63. 2013
    The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI) tract remains unknown. Here we studied the significance of GPR55 in the regulation of GI motility.
  63. doi A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function
    Julia Kargl
    Institute for Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria
    J Pharmacol Exp Ther 346:54-66. 2013
    The G protein-coupled receptor 55 (GPR55) is a lysophosphatidylinositol (LPI) receptor that is also responsive to certain cannabinoids...
  64. doi Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold
    Viktor Rempel
    PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D 53121 Bonn, Germany
    J Med Chem 56:4798-810. 2013
    The orphan G-protein-coupled receptor GPR55, which is activated by 1-lysophosphatidylinositol and interacts with cannabinoid (CB) receptor ligands, has been proposed as a new potential drug target for the treatment of diabetes, Parkinson'..
  65. doi 8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35
    Mario Funke
    PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D 53121 Bonn, Germany
    J Med Chem 56:5182-97. 2013
    ..The compounds were found to exhibit high selectivity versus the related GPR55. The most potent agonists were 6-bromo-8-(4-methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic acid (85, EC50 12...
  66. pmc The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists
    Alexander Fuchs
    PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, Bonn, Germany
    PLoS ONE 8:e77739. 2013
    ..362 µM; K(i ) CB2:0.0371 µM), which showed high selectivity versus GPR18 and GPR55. Compound 61b, an isomer of 61a, was the most potent GPR55 antagonist with an IC50 value of 3...
  67. doi Lysophosphatidylinositol signalling: new wine from an old bottle
    Roberto Piñeiro
    Queen Mary University of London, Barts and The Lodon School of Medicine and Dentistry, Blizard Istitute, Centre for Diabetes, Inositide Signalling Group, Lodon E1 2AT, UK
    Biochim Biophys Acta 1821:694-705. 2012
    ..for more than twenty years, the recent discovery that in several cell-types the orphan G protein-coupled receptor GPR55 acts as the specific receptor for LPI has fuelled novel interest in this lysolipid...
  68. doi The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas
    E Pérez-Gómez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 32:2534-42. 2013
    ..The orphan GPCR GPR55 was identified and cloned more than a decade ago, but very little is known about its physio-pathological relevance...
  69. doi GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors
    Pingwei Zhao
    Center for Substance Abuse Research and Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA
    Life Sci 92:453-7. 2013
    This review presents a summary of what is known about the G-protein coupled receptors GPR35 and GPR55 and their potential characterization as lysophospholipid or cannabinoid receptors, respectively...
  70. pmc A potential role for GPR55 in gastrointestinal functions
    Rudolf Schicho
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Austria
    Curr Opin Pharmacol 12:653-8. 2012
    ..10-15%) with cannabinoid-1 (CB(1)) and cannabinoid-2 (CB(2)) receptors, the G protein-coupled receptor 55 (GPR55) was initially thought to be a new member of the cannabinoid receptor family...
  71. pmc Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
    Alline Cristina Campos
    Group of Neuroimmunology, Laboratory of Immunopharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Philos Trans R Soc Lond B Biol Sci 367:3364-78. 2012
    ..g. inhibition of adenosine uptake, inverse agonism at CB2 receptor, CB1 receptor antagonism, GPR55 antagonism, PPARγ receptors agonism, intracellular (Ca(2+)) increase, etc.), on CBD behavioural effects.
  72. ncbi GPR55 and its interaction with membrane lipids: comparison with other endocannabinoid-binding receptors
    V Gasperi
    Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Curr Med Chem 20:64-78. 2013
    ..Recently, the orphan GPR55 receptor has been proved to be activated by many eCBs, thus leading to the hypothesis that it might be the "type-3"..
  73. pmc The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55
    Julia Kargl
    Institute for Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria
    J Biol Chem 287:44234-48. 2012
    The G protein-coupled receptor (GPCR) 55 (GPR55) and the cannabinoid receptor 1 (CB1R) are co-expressed in many tissues, predominantly in the central nervous system...
  74. pmc A homology modeling study toward the understanding of three-dimensional structure and putative pharmacological profile of the G-protein coupled receptor GPR55
    Orgil Elbegdorj
    Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E Leigh Street, Richmond, VA 23219 1540, USA
    J Mol Graph Model 39:50-60. 2013
    The orphan G-protein coupled receptor GPR55 was shown to bind to certain cannabinoid compounds which led to its initial classification as the third type of cannabinoid receptor...
  75. pmc The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55
    J Kargl
    Institute for Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Br J Pharmacol 165:2611-9. 2012
    ..The CB(1) receptor antagonist rimonabant has also recently been described to be an agonist at GPR55, a cannabinoid-related receptor...
  76. pmc Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala
    Antonia Serrano
    Laboratorio de Medicina Regenerativa, Hospital Regional Universitario Carlos Haya, Fundacion IMABIS, 29010 Malaga, Spain
    Alcohol Clin Exp Res 36:984-94. 2012
    ..Alcohol consumption alters brain endocannabinoid levels, and alcohol dependence is associated with dysregulated amygdalar function, stress responsivity, and affective control...
  77. doi The atypical cannabinoid O-1602 increases hind paw sensitisation in the chronic constriction injury model of neuropathic pain
    Courtney Breen
    Department of Pharmacology and Toxicology, Otago School of Medical Sciences, University of Otago, PO Box 913, Dunedin 9054, New Zealand
    Neurosci Lett 508:119-22. 2012
    O-1602 is an atypical cannabinoid that acts as an agonist at GPR55, a g protein-coupled receptor that previous studies have indicated may have a pronociceptive role in neuropathic pain...
  78. pmc Effects of palmitoylethanolamide on aqueous humor outflow
    Akhilesh Kumar
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Invest Ophthalmol Vis Sci 53:4416-25. 2012
    ..To study the effects of palmitoylethanolamide (PEA), a fatty acid ethanolamide, on aqueous humor outflow facility...
  79. pmc Evidence for the putative cannabinoid receptor (GPR55)-mediated inhibitory effects on intestinal contractility in mice
    Gracious R Ross
    Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Pharmacology 90:55-65. 2012
    ..The recently de-orphanized G-protein-coupled receptor, GPR55, has been proposed to be the 'third' cannabinoid receptor...
  80. ncbi Evolutionary origins of the endocannabinoid system
    John M McPartland
    GW Pharmaceuticals, 53 Washington Street Ext, Middlebury, VT 05753, USA
    Gene 370:64-74. 2006
    ..genes exhibited heterogeneous evolutionary trajectories, with functional orthologs limited to mammals (TRPV1 and GPR55), or vertebrates (CB2 and DAGLbeta), or chordates (MAGL and COX2), or animals (DAGLalpha and CB1-like receptors), ..
  81. ncbi A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio)
    J M McPartland
    GW Pharmaceuticals, Middlebury, VT 05753, USA
    Mol Genet Genomics 277:555-70. 2007
    ..expressed orthologs of cannabinoid receptor 1, transient receptor potential channel vanilloid receptor 4, GPR55 receptor, fatty acid amide hydrolase 1, monoacylglycerol lipase, NAPE-selective phospholipase D, abhydrolase ..
  82. ncbi Tempo and mode in the endocannaboinoid system
    John M McPartland
    GW Pharmaceuticals Ltd, Middlebury, VT 05753, USA
    J Mol Evol 65:267-76. 2007
    ..from highest to lowest: PTPN22, NAAA, TRPV1, TRPA1, NAPE-PLD, MAGL, PPARgamma, FAAH1, COX2, FAAH2, ABDH4, CB2, GPR55, DAGLbeta, PPARalpha, TRPV4, CB1, DAGLalpha; differences were significant (p < 0.0001)...
  83. pmc Endocannabinoids and the gastrointestinal tract: what are the key questions?
    G J Sanger
    Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development Limited, New Frontiers Science Park, Harlow, UK
    Br J Pharmacol 152:663-70. 2007
    ..What are the key questions which now need answering to further understand endocannabinoid pathophysiology? GPR55. Does this receptor have a GI role? Satiety, Nausea, Vomiting, Gastro-Oesophageal Reflux, Gastric Emptying...
  84. doi The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain
    Penny C Staton
    Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Pain 139:225-36. 2008
    It has been postulated that the G protein-coupled receptor, GPR55, is a third cannabinoid receptor...
  85. doi The enigmatic pharmacology of GPR55
    Ruth A Ross
    Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK
    Trends Pharmacol Sci 30:156-63. 2009
    ..data presented at conferences and in the patent literature introduced the possibility the orphan receptor GPR55 might account for some of the well-documented non-CB(1), non-CB(2) effects reported for certain cannabinoid ..
  86. doi Mode of action of cannabinoids on nociceptive nerve endings
    Michaela Kress
    Department of Physiology, Medical University Innsbruck, Innsbruck, Austria
    Exp Brain Res 196:79-88. 2009
    ..The cannabinoid receptor family currently includes two cloned metabotropic receptors: CB1, CB2 and possibly GPR55 which are distributed widely across many key loci in pain-modulating pathways, including the peripheral terminals ..
  87. pmc Candidate genes for cannabis use disorders: findings, challenges and directions
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Addiction 104:518-32. 2009
    ....
  88. doi Differential changes in GPR55 during microglial cell activation
    Maciej Pietr
    Neurobiology Department, Weizmann Institute of Science, Rehovot 76100, Israel
    FEBS Lett 583:2071-6. 2009
    ..IFN-gamma), known to differentially activate microglia, affect the expression of G protein-coupled receptor 55 (GPR55), a novel cannabinoid receptor...
  89. pmc Receptors for acylethanolamides-GPR55 and GPR119
    Grzegorz Godlewski
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Prostaglandins Other Lipid Mediat 89:105-11. 2009
    ..evidence for the existence of additional cannabinoid receptors, with the orphan G protein-coupled receptor GPR55 being the most actively scrutinized, and is one of the subjects of this review...
  90. doi Cannabinoids and the gut: new developments and emerging concepts
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II and Endocannabinoid Research Group, Naples, Italy
    Pharmacol Ther 126:21-38. 2010
    ..receptors, peroxisome proliferator-activated receptor alpha receptors and the orphan G-protein coupled receptors, GPR55 and GPR119...
  91. pmc Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists
    R G Pertwee
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
    Curr Med Chem 17:1360-81. 2010
    ..of such compounds to bind to, activate, inhibit or block non-CB(1), non- CB(2) G protein-coupled receptors such as GPR55, transmitter gated channels, ion channels and nuclear receptors in an orthosteric or allosteric manner...
  92. doi Cannabinoids and bone: friend or foe?
    Aymen I Idris
    Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Scotland, UK
    Calcif Tissue Int 87:285-97. 2010
    ..and synthetic cannabinoids, interact with the type 1 (CB(1)) and 2 (CB(2)) cannabinoid receptors and the GPR55 receptor to regulate cellular function through a variety of signaling pathways...
  93. pmc Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDS
    Santhi Gorantla
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198 5880, USA
    J Neuroimmune Pharmacol 5:456-68. 2010
    ..Brains of hu-PBL/HIVE mice showed microglial activation and increased expression of CB2R, but not CB1R or GPR55. Gp1a substantively reduced infiltration of human cells into the mouse brain and reduced HLA DQ activation...
  94. pmc Angiogenesis: a new physiological role for N-arachidonoyl serine and GPR55?
    W S V Ho
    Division of Basic Medical Sciences, St George s University of London, London, UK
    Br J Pharmacol 160:1580-2. 2010
    ..pro-angiogenic action is mediated, at least partly, by activation of the poorly characterized, G-protein-coupled GPR55 receptor...
  95. pmc Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections
    Chia Shan Wu
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Eur J Neurosci 32:693-706. 2010
    ..We first show that a deficiency in cannabinoid receptor type 1 (CB(1)R), but not G-protein-coupled receptor 55 (GPR55), leads to aberrant fasciculation and pathfinding in both corticothalamic and thalamocortical axons despite normal ..
  96. doi The putative cannabinoid receptor GPR55 promotes cancer cell proliferation
    G Hu
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Oncogene 30:139-41. 2011
    ..Recently, the orphan G protein-coupled receptor 55 (GPR55) was proposed to be an atypical cannabinoid receptor...
  97. doi Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum
    Pablo Pandolfo
    Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina UFSC, Florianopolis, SC, Brazil
    Eur J Pharmacol 655:38-45. 2011
    ..effect was: (1) unrelated to the pharmacological profile(s) of the ligands at the cannabinoid CB(1), CB(2), GPR55 and at the vanilloid TRPV(1) receptors; (2) not prevented by the cannabinoid CB(1) receptor antagonist/inverse ..
  98. pmc Cannabinoid receptors as target for treatment of osteoporosis: a tale of two therapies
    Aymen I Idris
    Bone Research Group, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Curr Neuropharmacol 8:243-53. 2010
    ..numerous studies also showed that bone cells express the cannabinoid receptors CB1 and CB2 and the orphan receptor GPR55. Pharmacological and genetic inactivation of CB1, CB2 and GPR55 in adult mice suppress bone resorption, increase ..
  99. doi A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells
    Toshiki Chiba
    Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai, Japan
    J Pharm Pharmacol 63:636-47. 2011
    ..In this study, we tried to elucidate possible effects of cannabinoids on lipopolysaccharide (LPS)-induced expression of inflammatory cytokine mRNAs in rat cerebellar granule cells...
  100. doi Modulation of the novel cannabinoid receptor - GPR55 - during rat fetoplacental development
    B M Fonseca
    Laboratorio de Bioquimica, Departamento Ciências Biológicas, Faculdade de Farmacia da Universidade do Porto, R Aníbal Cunha n 164, 4050 047 Porto, Portugal
    Placenta 32:462-9. 2011
    ..In order to investigate the expression of GPR55, referred as the novel cannabinoid receptor 3 (CB3), in the uterine maternal tissues during normal pregnancy we ..

Research Grants9

  1. Novel CB Receptors
    Nephi Stella; Fiscal Year: 2010
    ..We have recently confirmed that the orphan receptor GPR55 constitutes one such novel cannabinoid receptor...
  2. Jenny L Wiley; Fiscal Year: 2016
    ..One of our goals is to determine whether GPR55 is a cannabinoid receptor, and if so, what is its pharmacological properties and contribution to drug dependence...
  3. Cannabinoid Receptors and Novel Antiglaucoma Drugs
    Zhao Hui Song; Fiscal Year: 2010
    ..Specific Aim 1: To study the effects of non-CB1/CB2 cannabinoid agonists, and the role of GPR55, a novel, non- CB1/CB2 cannabinoid receptor on aqueous humor outflow...
  4. The regulation of cannabinoid receptors in microglial cells during HIV infection
    CATALIN FILIPEANU; Fiscal Year: 2012
    ..These actions are mediated by interactions with at least three specific receptors (CB1R, CB2R and GPR55) that are expressed in the central nervous system (CNS)...
  5. Mary E Abood; Fiscal Year: 2016
    ..and addiction are pharmacologically and biochemically well characterized, but some orphan receptors like GPR35 and GPR55, with homology to known receptors for drugs of abuse, remain poorly characterized...
  6. Identification of GPR55 cellular expression within hippocampal cells and its phys
    Jeffrey G Edwards; Fiscal Year: 2012
    ..One excellent candidate for this receptor is the yet to e classified orphan G protein receptor, GPR55, because it is expressed in the brain and is functionally active. Importantly, GPR55 binds eCBs such as anandamide...
  7. PATRICIA HODAPP REGGIO; Fiscal Year: 2016
    ..based upon novel crosslinking experiments and modeling studies;and (3) the development of novel, selective GPR55 (a putative cannabinoid receptor) antagonists based upon the results of a high-throughput, high-content screen of ..
  8. Marisela Agudelo; Fiscal Year: 2014
    ..The specific goals are to determine: 1. the levels of HDAC2, CB2, and GPR55 in M.D.DCs from alcohol abusers, normal donors, and alcohol treated cells. 2...
  9. Optimization of High Selectivity Antagonist Hits for the GPR55 Receptor
    PATRICIA HODAPP REGGIO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): GPR55 is a rhodopsin-like (Class A) G protein-coupled receptor (GPCR), highly expressed in human striatum (Genbank accession # NM-005683)...