GNAT3

Summary

Gene Symbol: GNAT3
Description: G protein subunit alpha transducin 3
Alias: GDCA, guanine nucleotide-binding protein G(t) subunit alpha-3, guanine nucleotide binding protein, alpha transducing 3, gustatory G protein, gustducin alpha-3 chain, gustducin, alpha polypeptide
Species: human

Top Publications

  1. pmc Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
    Hyeung Jin Jang
    National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:15069-74. 2007
  2. pmc Association between common variation in genes encoding sweet taste signaling components and human sucrose perception
    Alexey A Fushan
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Chem Senses 35:579-92. 2010
  3. doi Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits
    Quan Shang
    Department of Medicine, Rutgers, New Jersey Medical School, Newark, New Jersey Medical Research Service, Veterans Affairs Medical Center, East Orange, New Jersey
    Am J Physiol Gastrointest Liver Physiol 307:G479-86. 2014
  4. ncbi Anisotropy in laser performance of Yb:GdCa4O(BO3)3 crystal
    Junhai Liu
    College of Physics, Qingdao University, Ning Xia Road 308, Qingdao 266071, China
    Appl Opt 47:5436-41. 2008
  5. ncbi First measurement of the nonlinear coefficient for Gd(1-X)Lu(X)Ca(4)O(BO(3))(3) and Gd(1-X)Sc(X)Ca(4)O(BO(3))(3) crystals
    Martin T Andersen
    Technical University of Denmark, Department of Physics, DK 2800 Kgs Lyngby
    Opt Express 15:4893-901. 2007
  6. doi Thermodynamic and solution state NMR characterization of the binding of secondary and conjugated bile acids to STARD5
    Danny Létourneau
    Departement de Biochimie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    Biochim Biophys Acta 1831:1589-99. 2013
  7. doi Functional role of tlyC1 encoding a hemolysin-like protein from Bifidobacterium longum BBMN68 in bile tolerance
    Ying Liu
    Key Laboratory of Functional Dairy, Co constructed by Ministry of Education and Beijing Municipality, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China
    FEMS Microbiol Lett 360:167-73. 2014
  8. pmc Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients
    Benjamin L Woolbright
    Department of Pharmacology, Toxicology and Therapeutics, Department of Biostatistics, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, Arizona 85006, Department of Medicine, and Center for Toxicology and Pharmacology Education and Research, University of Arizona College of Medicine, Phoenix, Arizona 85006 and Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390
    Toxicol Sci 142:436-44. 2014
  9. doi Dynamic contrast-enhanced MRI in mouse tumors at 11.7 T: comparison of three contrast agents with different molecular weights to assess the early effects of combretastatin A4
    A C Fruytier
    Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    NMR Biomed 27:1403-12. 2014
  10. doi Gadolinium nanoparticles and contrast agent as radiation sensitizers
    Florence Taupin
    Université Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F 38000 Grenoble, France INSERM, U836, F 38000 Grenoble, France Université Grenoble Alpes, INAC SCIB, LAN, F 38000 Grenoble, France CEA, INAC SCIB, F 38000 Grenoble, France European Synchrotron Radiation Facility, F 38000 Grenoble, France
    Phys Med Biol 60:4449-64. 2015

Research Grants

Scientific Experts

  • Junhai Liu
  • Xiao Quan Yang
  • Vidya Farook
  • Habtom W Ressom
  • Waldemar Soluch
  • Yoshiro Ishimaru
  • S Swaminathan
  • Paul Dent
  • Robert F Margolskee
  • Ewa Ellis
  • Yuri A Blednov
  • E Rozengurt
  • Robert E Steinert
  • R E Roberts
  • P Wollmer
  • DANIELLE RENEE REED
  • JUAN ROZENGURT
  • JUAN ENRIQUE ROZENGURT
  • Guohong Wang
  • Yanling Hao
  • Haoran An
  • Bedrich Mosinger
  • Chun Liu
  • Nicholas Steven Archer
  • Florence Taupin
  • Marco Tizzano
  • N Shoji
  • Seung Kee Cho
  • Fazheng Ren
  • Quan Shang
  • A C Fruytier
  • Benjamin L Woolbright
  • Ying Liu
  • April D Lake
  • Marta Conde-Sieira
  • Danny Létourneau
  • Jiaqi Dai
  • Jose L Soengas
  • Sergio Polakof
  • Filipe M Coreta-Gomes
  • Jun Feng Xiao
  • Ana Yanina Bustos
  • Elaine Studer
  • Antti Knaapila
  • Daniel Xia
  • S Wendell
  • Alexey A Fushan
  • Anand Khurana
  • Martin T Andersen
  • Johanna Fehr
  • Hyeung Jin Jang
  • Nora Rozengurt
  • William M Oldham
  • Jun Yang
  • Garry Hannan
  • Xiao Lu Lin
  • E Tessier
  • Jan Shaw
  • Russell Keast
  • Dongli Liu
  • Yuan Zou
  • Konsta Duesing
  • Zhili Wan
  • Fen Fen Cheng
  • Dae Kyung Kang
  • François Lux
  • M Kawai
  • Matthew S Clary
  • H Uneyama
  • Lucie Sancey
  • Rachel Delorme
  • S Satoh-Kuriwada
  • Rolf F Barth
  • Xiayin Ma
  • Ling Li
  • Nicole Shultz
  • Josiane Arnaud
  • Jean François Mayol
  • Mélanie Flaender
  • M Tsuchiya
  • Zhengyuan Zhai
  • Pascal Perriat
  • Nam Soo Han
  • Laura Grigereit
  • Thomas E Finger
  • Wooha Joo
  • N Kaneta
  • Marie Carriere
  • Dan Li
  • Jean Luc Ravanat

Detail Information

Publications61

  1. pmc Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
    Hyeung Jin Jang
    National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:15069-74. 2007
    ..Modulating GLP-1 secretion in gut "taste cells" may provide an important treatment for obesity, diabetes and abnormal gut motility...
  2. pmc Association between common variation in genes encoding sweet taste signaling components and human sucrose perception
    Alexey A Fushan
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Chem Senses 35:579-92. 2010
    ..analysis revealed significant correlation of sucrose AUC scores with genetic variation occurring in the GNAT3 gene (single point P = 10(-3) to 10(-4)), which encodes the taste-specific G(alpha) protein subunit gustducin...
  3. doi Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits
    Quan Shang
    Department of Medicine, Rutgers, New Jersey Medical School, Newark, New Jersey Medical Research Service, Veterans Affairs Medical Center, East Orange, New Jersey
    Am J Physiol Gastrointest Liver Physiol 307:G479-86. 2014
    ..A rabbit model was developed by infusing glycodeoxycholic acid (GDCA) through the splenic vein to bypass ileal FGF19...
  4. ncbi Anisotropy in laser performance of Yb:GdCa4O(BO3)3 crystal
    Junhai Liu
    College of Physics, Qingdao University, Ning Xia Road 308, Qingdao 266071, China
    Appl Opt 47:5436-41. 2008
    We report distinct laser performance of Yb:GdCa(4)O(BO(3))(3) crystals cut along different principal optical axes using an unpolarized diode pump...
  5. ncbi First measurement of the nonlinear coefficient for Gd(1-X)Lu(X)Ca(4)O(BO(3))(3) and Gd(1-X)Sc(X)Ca(4)O(BO(3))(3) crystals
    Martin T Andersen
    Technical University of Denmark, Department of Physics, DK 2800 Kgs Lyngby
    Opt Express 15:4893-901. 2007
    The effective nonlinear coefficient and temperature acceptance bandwidth of three Lu and Sc co-doped GdCa(4)O(BO(3))(3) type nonlinear crystals were measured...
  6. doi Thermodynamic and solution state NMR characterization of the binding of secondary and conjugated bile acids to STARD5
    Danny Létourneau
    Departement de Biochimie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    Biochim Biophys Acta 1831:1589-99. 2013
    ..The relative STARD5 affinity for the different bile acids studied is: DCA>LCA>CDCA>GDCA>TDCA>CA>UDCA. TCA and GCA do not bind significantly to STARD5...
  7. doi Functional role of tlyC1 encoding a hemolysin-like protein from Bifidobacterium longum BBMN68 in bile tolerance
    Ying Liu
    Key Laboratory of Functional Dairy, Co constructed by Ministry of Education and Beijing Municipality, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China
    FEMS Microbiol Lett 360:167-73. 2014
    ..to sublethal concentration of TCA and TDCA, while no significant change was observed when exposed to GCA and GDCA. Furthermore, real-time quantitative PCR demonstrated that the transcription of tlyC1 was up-regulated c. 2...
  8. pmc Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients
    Benjamin L Woolbright
    Department of Pharmacology, Toxicology and Therapeutics, Department of Biostatistics, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, Arizona 85006, Department of Medicine, and Center for Toxicology and Pharmacology Education and Research, University of Arizona College of Medicine, Phoenix, Arizona 85006 and Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390
    Toxicol Sci 142:436-44. 2014
    ..Interestingly, glycodeoxycholic acid (GDCA) was significantly increased in non-surviving AALF patients compared with survivors...
  9. doi Dynamic contrast-enhanced MRI in mouse tumors at 11.7 T: comparison of three contrast agents with different molecular weights to assess the early effects of combretastatin A4
    A C Fruytier
    Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    NMR Biomed 27:1403-12. 2014
    ..bearing transplantable liver tumor (TLT) hepatocarcinoma were divided into two groups (n = 5-6 per group and per GdCA): a treated group receiving 100 mg/kg CA4, and a control group receiving vehicle. The mice were imaged at 11...
  10. doi Gadolinium nanoparticles and contrast agent as radiation sensitizers
    Florence Taupin
    Université Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F 38000 Grenoble, France INSERM, U836, F 38000 Grenoble, France Université Grenoble Alpes, INAC SCIB, LAN, F 38000 Grenoble, France CEA, INAC SCIB, F 38000 Grenoble, France European Synchrotron Radiation Facility, F 38000 Grenoble, France
    Phys Med Biol 60:4449-64. 2015
    ..and compare the radiosensitizing properties of gadolinium nanoparticles (NPs) with the gadolinium contrast agent (GdCA) Magnevist(®) in order to better understand the mechanisms by which they act as radiation sensitizers...
  11. doi Expression of umami-taste-related genes in the tongue: a pilot study for genetic taste diagnosis
    N Shoji
    Division of Oral Diagnosis, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Oral Dis 21:801-6. 2015
    ..Expression of taste-related genes in the tongue was analysed to develop a technique for genetic diagnosis of umami taste disorders...
  12. doi Functional role of oppA encoding an oligopeptide-binding protein from Lactobacillus salivarius Ren in bile tolerance
    Guohong Wang
    Key Laboratory of Functional Dairy, Co constructed by Ministry of Education and Beijing Municipality, College of Food Science and Nutritional Engineering, China Agricultural University, 17 Qing Hua East Road, Hai Dian District, Beijing, 100083, China
    J Ind Microbiol Biotechnol 42:1167-74. 2015
    ..while no significant change was observed when exposed to sodium glycocholate and sodium glycodeoxycholate (GDCA). Our results indicate that OppA confers specific resistance to taurine-conjugated bile salts in L. salivarius Ren...
  13. doi Development of Bile Salt-Resistant Leuconostoc citreum by Expression of Bile Salt Hydrolase Gene
    Seung Kee Cho
    Brain Korea 21 Center for Bio Resource Development, Division of Animal, Horticultural, and Food Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Microbiol Biotechnol 25:2100-5. 2015
    ..Upon incubation with glycodeoxycholic acid sodium salt (GDCA), the L...
  14. pmc Immunohistochemical Analysis of Human Vallate Taste Buds
    Marco Tizzano
    Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, 12801 E 17th Avenue, Aurora, CO 80045, USA, Department of Cell and Developmental Biology, University of Colorado School of Medicine, 12801 E 17th Avenue, Aurora, CO 80045, USA and
    Chem Senses 40:655-60. 2015
    ..The typical taste cell markers PLCβ2, GNAT3 (gustducin) and the T1R3 receptor stain elongated cells in human taste buds consistent with the Type II cells in ..
  15. pmc A Comparison of Collection Techniques for Gene Expression Analysis of Human Oral Taste Tissue
    Nicholas Steven Archer
    Food and Nutrition, CSIRO, Sydney, Australia
    PLoS ONE 11:e0152157. 2016
    ..the assessed taste receptor genes (TAS1R1, TAS1R2, TAS1R3, SCNN1A and CD36) and taste tissue marker genes (NCAM1, GNAT3 and PLCβ2)...
  16. ncbi The physicochemical properties, in vitro binding capacities and in vivo hypocholesterolemic activity of soluble dietary fiber extracted from soy hulls
    Chun Liu
    Research and Development Center of Food Proteins, School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, People s Republic of China
    Food Funct 7:4830-4840. 2016
    ..62 mg g-1 sample at pH 7), bile acid-binding capacity (3.3, 1.73 and 6.65 μM of GCA, GCDCA and GDCA per 100 mg of sample), glucose dialysis retardation index (64.76%), and in vivo hypocholesterolemic activity (16...
  17. pmc Metabolic syndrome is linked to chromosome 7q21 and associated with genetic variants in CD36 and GNAT3 in Mexican Americans
    Vidya S Farook
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA
    Obesity (Silver Spring) 20:2083-92. 2012
    ..the fatty acid translocase (FAT or CD36, 18 SNPs) gene and guanine nucleotide binding protein, α transducing 3 (GNAT3, 11 SNPs) gene, located within the 1-LOD support interval region for their association with MS and its related ..
  18. doi Relationship between bile salt hydrolase activity, changes in the internal pH and tolerance to bile acids in lactic acid bacteria
    Ana Yanina Bustos
    Centro de Referencia para Lactobacilos CERELA CONICET, Chacabuco 145, T4000ILC, San Miguel de Tucuman, Argentina
    Biotechnol Lett 34:1511-8. 2012
    ..a gradual increase in the pHin following the addition of conjugated BA; this behavior was more pronounced with GDCA than with TDCA may be due to the higher affinity of BSH for the glyco-conjugates acids...
  19. doi Quantification of cholesterol solubilized in bile salt micellar aqueous solutions using (13)C nuclear magnetic resonance
    Filipe M Coreta-Gomes
    Department of Chemistry, University of Coimbra, 3004 535 Coimbra, Portugal
    Anal Biochem 427:41-8. 2012
    ..work, we develop a methodology to quantitatively follow the solubilization of cholesterol on glycodeoxycholic acid (GDCA) micelles using (13)C nuclear magnetic resonance (NMR)...
  20. pmc Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis
    Habtom W Ressom
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA
    Anal Chim Acta 743:90-100. 2012
    ..such as glycochenodeoxycholic acid 3-sulfate (3-sulfo-GCDCA), glycocholic acid (GCA), glycodeoxycholic acid (GDCA), taurocholic acid (TCA), and taurochenodeoxycholate (TCDCA)...
  21. pmc Genetic analysis of chemosensory traits in human twins
    Antti Knaapila
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA
    Chem Senses 37:869-81. 2012
    ..of basil and a bitter taste receptor gene, TAS2R60, and between cilantro and variants in three genes (TRPA1, GNAT3, and TAS2R50)...
  22. pmc Expression analysis of taste signal transduction molecules in the fungiform and circumvallate papillae of the rhesus macaque, Macaca mulatta
    Yoshiro Ishimaru
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 7:e45426. 2012
    ..b>GNAT3, but not GNA14, was expressed in TRCs of FuP, whereas GNA14 was expressed in a small population of TRCs of CvP, ..
  23. doi ACTH-stimulated cortisol release from head kidney of rainbow trout is modulated by glucose concentration
    Marta Conde-Sieira
    Laboratorios de Fisioloxía Animal, Departamento de Bioloxia Funcional e Ciencias da Saude, Facultade de Bioloxia, Universidade de Vigo, Spain
    J Exp Biol 216:554-67. 2013
    ..in the presence of ACTH were noted for any other putative glucosensor mechanisms based on LXR, SGLT-1 or Gnat3. These combined results are the first evidence for a mechanism in fish linking the synthesis and release of a non-..
  24. doi Properties of SAW synchronous two-port resonators on GdCa₄O(BO₃)₃ crystal
    Waldemar Soluch
    Institute of Electronic Materials Technology, Warsaw, Poland
    IEEE Trans Ultrason Ferroelectr Freq Control 58:485-7. 2011
    ..acoustic wave (SAW) synchronous two-port resonators were fabricated and measured on several orientations of the GdCa₄O(BO₃)₃ crystal...
  25. pmc LC-MS based serum metabolomics for identification of hepatocellular carcinoma biomarkers in Egyptian cohort
    Jun Feng Xiao
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States
    J Proteome Res 11:5914-23. 2012
    ..verified the identities of selected putative identifications including glycholic acid (GCA), glycodeoxycholic acid (GDCA), 3β, 6β-dihydroxy-5β-cholan-24-oic acid, oleoyl carnitine, and Phe-Phe...
  26. doi Bile acids affect the growth of human cholangiocarcinoma via NF-kB pathway
    Jiaqi Dai
    Divisions of General Surgery, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer Invest 31:111-20. 2013
    ..inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth...
  27. pmc T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1
    Robert F Margolskee
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 104:15075-80. 2007
    ....
  28. pmc Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease
    April D Lake
    University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ 85721, USA
    Toxicol Appl Pharmacol 268:132-40. 2013
    ..Conversely, cholic acid (CA) and glycodeoxycholic acid (GDCA) were decreased in NASH liver...
  29. doi Efficient high-energy passively Q-switched Yb:GdCa4O(BO3)3 laser
    Junhai Liu
    College of Physics, Qingdao University, Qingdao, China
    Appl Opt 52:2676-81. 2013
    A compact diode-pumped high-pulse-energy Yb:GdCa(4)O(BO(3))(3) laser passively Q-switched with a Cr(4+):YAG saturable absorber is demonstrated at room temperature. An output power of 1.05 W is generated at a pulse repetition rate of 2...
  30. pmc Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility
    Bedrich Mosinger
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 110:12319-24. 2013
    ..genetic absence of both TAS1R3, a component of sweet and amino acid taste receptors, and the gustducin α-subunit GNAT3 leads to male-specific sterility...
  31. ncbi Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon
    Nora Rozengurt
    Department of Pathology, David Geffen School of Medicine, University of California Los Angeles, 900 Veteran Ave, Warren Hall Rm 11 115, Los Angeles, CA 90095 1786, USA
    Am J Physiol Gastrointest Liver Physiol 291:G792-802. 2006
    ....
  32. ncbi High performance liquid chromatography-mass spectrometry for metabonomics: potential biomarkers for acute deterioration of liver function in chronic hepatitis B
    Jun Yang
    National Chromatographic R and A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, China
    J Proteome Res 5:554-61. 2006
    ..LPC C16:0, LPC C18:1, LPC C18:2, and glycochenodeoxycholic acid (GCDCA) (or its isomer glycodeoxycholic acid (GDCA))...
  33. doi Evidence of sugar sensitive genes in the gut of a carnivorous fish species
    Sergio Polakof
    INRA, UMR 1019, UNH, CRNH Auvergne, Clermont Ferrand, France
    Comp Biochem Physiol B Biochem Mol Biol 166:58-64. 2013
    ..nuclear receptor nr1h3 and the components of the G-protein-coupled taste receptors (tas1r2-like, tas1r3-like and gnat3-like)...
  34. ncbi High-performance liquid chromatographic mass spectrometric method for the determination of ursodeoxycholic acid and its glycine and taurine conjugates in human plasma
    E Tessier
    Pharmascience, Montreal, Que, Canada H4P 2T4
    J Chromatogr B Analyt Technol Biomed Life Sci 798:295-302. 2003
    ..the determination of ursodeoxycholic acid (UDCA) and its glycine and taurine conjugates, glycoursodeoxycholic acid (GDCA) and tauroursodeoxycholic acid (TDCA)...
  35. ncbi The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2
    M A Wall
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Cell 83:1047-58. 1995
    ..Repeated WD motifs in beta form a circularized sevenfold beta propeller. The conserved cores of these motifs are a scaffold for display of their more variable linkers on the exterior face of each propeller blade...
  36. pmc Taste genes associated with dental caries
    S Wendell
    Center for Oral Health Research in Appalachia, University of Pittsburgh, PA, USA
    J Dent Res 89:1198-202. 2010
    ..We therefore hypothesized that genetic variation in taste pathway genes (TAS2R38, TAS1R2, GNAT3) may be associated with dental caries risk and/or protection...
  37. ncbi Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes
    Paul Dent
    Department of Radiation Oncology and Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, 23298, USA
    Hepatology 42:1291-9. 2005
    ..Deoxycholic acid (DCA), chenodeoxycholic acid (CDCA), taurodeoxycholic acid (TDCA), glycodeoxycholic acid (GDCA), taurochenodeoxycholic acid (TCDCA), glycochenodeoxycholic acid (GCDCA), taurocholic acid (TCA), glycocholic acid (..
  38. ncbi Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein
    D G Lambright
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510
    Nature 369:621-8. 1994
    ..The changes are distinct from those observed in other members of the GTPase superfamily...
  39. ncbi Different feedback regulation of hepatic cholesterol and bile acid synthesis by glycodeoxycholic acid in rabbits
    G Xu
    University of Medicine and Dentistry New Jersey Medical School, Newark
    Gastroenterology 105:1192-9. 1993
    To explore the sexual difference in the feedback regulation of hepatic bile acid synthesis, glycodeoxycholic acid (GDCA) was administered to 15 male and 14 female rabbits.
  40. ncbi Comparison of hypolipidemic effect of refined konjac meal with several common dietary fibers and their mechanisms of action
    J Wu
    Department of Nutrition and Food Hygiene, Nantong Medical College, Jiangsu, China
    Biomed Environ Sci 10:27-37. 1997
    ..The daily output of fecal bile acids (CDCA + GDCA) was significantly increased in the four experimental groups than in the normal group and the control group...
  41. ncbi Co-mutagenicity of glyco- and tauro-deoxycholic acids in the Ames test
    N Shibuya
    Biochemical Laboratory, Niigata College of Medical Technology, Japan
    Mutat Res 395:1-7. 1997
    Mutagenicity and co-mutagenicity of glyco- and tauro-deoxycholic acids (GDCA and TDCA), which are abundant in human bile, were examined by the Ames test...
  42. ncbi [Glycodeoxycholic acid changes the membrane fluidity and superoxides of lipids in hepatocytes]
    W Huang
    Department of Clinical Laboratory, Chongqing University of Medical Sciences
    Zhonghua Gan Zang Bing Za Zhi 7:46-7. 1999
    To explore the mechanisms of hepatocyte injury caused by glycodeoxycholic acid (GDCA) through studies on the roles of GDCA to membrane fluidity and superoxides of lipids of hepatocyte.
  43. ncbi Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium
    L Huang
    Howard Hughes Medical Institute, Mount Sinai School of Medicine of New York University, Box 1677, One Gustave L Levy Place, New York, New York 10029, USA
    Nat Neurosci 2:1055-62. 1999
    ..We conclude that gustducin heterotrimers transduce responses to bitter and sweet compounds via alpha-gustducin's regulation of phosphodiesterase (PDE) and Gbetagamma's activation of phospholipase C (PLC)...
  44. ncbi Comparison of the effects of bile acids on cell viability and DNA synthesis by rat hepatocytes in primary culture
    M C Martinez-Diez
    Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, 37007, Salamanca, Spain
    Biochim Biophys Acta 1500:153-60. 2000
    ..incorporation into DNA was only slightly lower for taurodeoxycholic acid (TDCA) and glycodeoxycholic acid (GDCA) than for DCA...
  45. ncbi Surface active agents as enhancers of alveolar absorption
    P Wollmer
    Department of Clinical Physiology, University of Lund, Sweden
    Pharm Res 17:38-41. 2000
    ..The purpose of this study was to examine the effects of a selection of different surface active agents on alveolar absorption...
  46. ncbi Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)
    A Caricasole
    Biology Department, GlaxoWellcome Medicines Research Centre, Verona, Italy
    Biochim Biophys Acta 1517:63-72. 2000
    ..Finally, we characterized the structure of the PLC beta 1 locus and confirmed its mapping to human chromosome 20...
  47. ncbi Combined use of Lactobacillus reuteri and soygerm powder as food supplement
    P De Boever
    Laboratory of Microbial Ecology and Technology LabMET, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Lett Appl Microbiol 33:420-4. 2001
    The survival of Lactobacillus reuteri when challenged with glycodeoxycholic acid (GDCA), deoxycholic acid (DCA) and soygerm powder was investigated. Moreover, the impact of Lact...
  48. pmc Human receptors for sweet and umami taste
    Xiaodong Li
    Senomyx, Inc, 11099 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:4692-6. 2002
    ..The ligand specificities of rat T1R2/T1R3 and T1R1/T1R3 correspond to those of their human counterparts. These findings implicate the T1Rs in umami taste and suggest that sweet and umami taste receptors share a common subunit...
  49. ncbi Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor
    Ewa Ellis
    Division of Gastroenterology and Hepatology, Department of Medicine, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    Hepatology 38:930-8. 2003
    ..significantly decreased formation of cholic acid (CA) to 44% +/- 4% of controls and glycodeoxycholic acid (GDCA) decreased formation of CA to 67% +/- 11% of controls...
  50. pmc Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes
    Elaine Studer
    Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298 0678, USA
    Hepatology 55:267-76. 2012
    ..taurodeoxycholic acid (TDCA), tauroursodeoxycholic acid (TUDCA), glycocholic acid (GCA), glycodeoxycholic acid (GDCA), and S1P-induced activation of ERK1/2 and AKT were significantly inhibited by JTE-013, a S1P(2) antagonist, in ..
  51. ncbi Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins
    William M Oldham
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6600, USA
    Nat Struct Mol Biol 13:772-7. 2006
    ..These data provide the first direct observation of R*-mediated conformational changes in G proteins and define the structural basis for GDP release from G alpha...
  52. ncbi Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa
    Johanna Fehr
    Department of Pharmacology and Toxicology, Philipps University Marburg, Karl von Frisch Strasse 1, 35032, Marburg, Germany
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:21-34. 2007
    ....
  53. pmc Perception of sweet taste is important for voluntary alcohol consumption in mice
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin, TX 78712 0159, USA
    Genes Brain Behav 7:1-13. 2008
    ..mutant mice, each lacking a gene expressed in taste buds and critical to taste transduction: alpha-gustducin (Gnat3), Tas1r3 or Trpm5...
  54. doi Quantification of gadolinium in nephrogenic systemic fibrosis: re-examination of a reported cohort with analysis of clinical factors
    Anand Khurana
    Department of Nephrology, Scott and White Clinic, Texas A and M University, College Station, Texas, USA
    J Am Acad Dermatol 59:218-24. 2008
    Nephrogenic systemic fibrosis (NSF) has been associated with exposure to gadolinium-based contrast agent (GdCA) used in medical imaging.
  55. doi Rapid improvement of nephrogenic systemic fibrosis with rapamycin therapy: possible role of phospho-70-ribosomal-S6 kinase
    Sundararaman Swaminathan
    Division of Nephrology, Atlanta Veterans Administration Health Center, Emory University School of Medicine, Atlanta, Georgia, USA
    J Am Acad Dermatol 62:343-5. 2010
    ..Exposure to gadolinium-based contrast agents (GdCA) has been associated with the development of NSF. No uniformly effective treatment options exist...
  56. pmc Gustation genetics: sweet gustducin!
    Danielle R Reed
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 35:549-50. 2010
    ..evidence that genetic variation in the sweet receptor subunit, TAS1R3, and the second messenger, gustducin (GNAT3), affect the ability of people to correctly sort ascending concentrations of sucrose...
  57. doi Coexpression of bile salt hydrolase gene and catalase gene remarkably improves oxidative stress and bile salt resistance in Lactobacillus casei
    Guohong Wang
    Key Laboratory of Functional Dairy of Ministry of Education of People s Republic of China and Municipal Government of Beijing, College of Food Science and Nutritional Engineering, China Agricultural University, Hai Dian District, Beijing, 100083, China
    J Ind Microbiol Biotechnol 38:985-90. 2011
    ..casei CK. Treatment of L. casei CB with various concentrations of sodium glycodeoxycholate (GDCA) showed that ~10(5) CFU/ml cells survived after incubation with 0.5% GDCA, whereas almost all the L...
  58. ncbi Human taste cells express the G protein alpha-gustducin and neuron-specific enolase
    S Takami
    Department of Physiology and Biophysics, University of Kentucky College of Medicine, Lexington 40536 0084
    Brain Res Mol Brain Res 22:193-203. 1994
    ..The patterns of expression of alpha-gustducin, and coexpression with NSE, may correlate with specialized subtypes or developmental stages of taste receptor cells...
  59. doi Gadolinium released from MR contrast agents is deposited in brain tumors: in situ demonstration using scanning electron microscopy with energy dispersive X-ray spectroscopy
    Daniel Xia
    Department of Pathology, SUNY Upstate Medical University, Syracuse, NY 3210, USA
    Acta Radiol 51:1126-36. 2010
    gadolinium (Gd)-containing MRI contrast agents (GdCA) are widely used in studies of brain tumors, and a number of reports suggest that under certain conditions, such as renal failure, Gd may be released from GdCA into patient's tissues...
  60. doi The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin
    R E Roberts
    King s College London School of Medicine, UK
    Clin Endocrinol (Oxf) 74:67-72. 2011
    ..Entero-endocrine L-cells can be stimulated by nutrients and or bile acids to co-secrete PYY and GLP-1. The aim of this study was to determine the response of bile acids, PYY, GLP-1 and ghrelin after a test meal...
  61. doi The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)
    R E Steinert
    Clinical Research Center, Department of Biomedicine, Switzerland
    Clin Nutr 30:524-32. 2011
    ..Enteroendocrine cells are thought to directly sense nutrients via α-gustducin coupled taste receptors (originally identified in the oral epithelium) to modulate the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)...

Research Grants5

  1. Novel Machine Learning Methods for Analysis of MALDI-TOF Mass Spectrometry Data
    Habtom Ressom; Fiscal Year: 2008
    ..Furthermore, the peptides represented by the selected candidate biomarkers will be identified. Finally, the performance of the algorithm will be compared with existing methods. [unreadable] [unreadable] [unreadable]..
  2. GENETICS OF BITTER TASTE PERCEPTION IN HUMANS
    DANIELLE REED; Fiscal Year: 2002
    ..In Specific Aim 3, the P.I. will initiate an evaluation of candidate genes located within the region identified, by screening for variabilities associated with PROP-taster status. ..
  3. The International Symposium on Regulatory Peptides
    JUAN ROZENGURT; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ....